Page last updated: 2024-09-02

ramosetron and ondansetron

ramosetron has been researched along with ondansetron in 46 studies

Compound Research Comparison

Studies
(ramosetron)
Trials
(ramosetron)
Recent Studies (post-2010)
(ramosetron)
Studies
(ondansetron)
Trials
(ondansetron)
Recent Studies (post-2010) (ondansetron)
19494833,3801,216994

Protein Interaction Comparison

ProteinTaxonomyramosetron (IC50)ondansetron (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)10
Solute carrier family 22 member 2Homo sapiens (human)1.295
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)10
5-hydroxytryptamine receptor 3ARattus norvegicus (Norway rat)0.0136
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.717
5-hydroxytryptamine receptor 3AHomo sapiens (human)0.0001
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)10
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)10
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.7303
Multidrug and toxin extrusion protein 2Homo sapiens (human)2.4533
GABA theta subunitRattus norvegicus (Norway rat)10
Multidrug and toxin extrusion protein 1Homo sapiens (human)0.0875
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)10
5-hydroxytryptamine receptor 3BRattus norvegicus (Norway rat)0.0181

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (23.91)18.2507
2000's10 (21.74)29.6817
2010's22 (47.83)24.3611
2020's3 (6.52)2.80

Authors

AuthorsStudies
Barnes, NM; Brady, CA; Butler, AS; Choo, SH; Cioffi, CL; Cohen, ML; Dobritsa, S; Earley, WG; Fitzpatrick, K; Guo, C; Guzzo, PR; Hassler, C; Manning, DD; Masih, L; Naginskaya, J; Ryan, KN; Sikkander, MI; Usyatinsky, A; Wierschke, JD; Zhang, Z1
Ito, H; Iwai, A; Kamato, T; Katsuyama, Y; Miyata, K; Nishida, A; Ohta, M; Tsutsumi, R; Yamano, M; Yuki, H1
Akuzawa, S; Ito, H; Kamato, T; Kiso, T; Miyata, K; Nishida, A; Tsutsumi, R; Yamano, M1
Honda, K; Ito, H; Kamato, T; Miyata, K; Nishida, A; Tsutsumi, R; Yamano, M; Yuki, H1
Ichikawa, S; Ishii, A; Karasawa, A; Kishibayashi, N; Yokoyama, T1
Akuzawa, S; Kamato, T; Miyata, K; Yamano, M1
Furuya, T; Kurihara, H; Miyata, K; Ohta, M; Suzuki, T; Tokunaga, T; Yanagisawa, I1
Mase, T; Miyata, K; Nagashima, S; Ohta, M; Suzuki, T; Tokunaga, T1
Kamato, T; Miyata, K; Nagakura, Y; Naitoh, Y; Yamano, M1
Tsukagoshi, S1
Kamato, T; Miyata, K; Nagakura, Y; Yamano, M1
Blower, PR; Endo, T; Hamaue, N; Hirafuji, M; Kitamura, N; Minami, M; Nemoto, M; Ogawa, T; Teramoto, Y; Yasuda, E1
Akutagawa, N; Ishioka, S; Ito, E; Kiya, T; Kudo, R; Sagae, S; Saito, T; Sugimura, M; Umemura, K1
Akamatsu, H; Mikawa, K; Nishina, K; Niwa, Y; Shiga, M1
Liu, DW; Liu, YY; Shan, XJ; Xie, XD; Zheng, ZD1
Ikeda, K; Kobayashi, N; Niwa, T; Noda, Y; Saito, M; Takagi, A; Yamamoto, S1
Ai, B; Dong, M; Han, X; He, X; Huang, D; Liu, P; Shi, Y; Yang, S; Zhang, C; Zhou, S1
Hashimoto, R; Ikeda, K; Kurokawa, N; Okamoto, Y; Takagi, T; Takenaka, M; Ueda, T; Uejima, E1
Choi, YS; Jeon, DH; Kwak, YL; Lee, JY; Shim, JK; Yoon, DH1
Bang, YJ; Chie, EK; Ha, SW; Im, SA; Jang, JY; Kim, K; Kim, SW; Kim, TY; Oh, DY1
Baek, YH; Kim, SC; Kim, SH; Kim, SI; Ok, SY1
Do, SH; Hwang, J; Ryu, J; So, YM1
Ayuhara, H; Okuyama, K; Ozeki, T; Takayanagi, R; Yamada, Y; Yokoyama, H; Yoshimoto, K1
Mraovic, B; Simurina, T1
Choi, SJ; Gwak, MS; Hahm, TS; Ko, JS1
Fujii, Y1
Chin, JH; Choi, DK; Choi, IC; Chung, CH; Lee, EH; Lim, OB; Ro, YJ1
Akhtar, S; Ansari, MM; Haleem, S; Khan, FA; Siddiqui, OA; Varshney, R1
Amagase, K; Horie, S; Iimori, M; Kato, S; Kitahara, Y; Matsumoto, K; Takeuchi, K; Utsumi, D; Yamanaka, N; Yasuda, M1
Byon, HJ; Jang, YE; Kim, HS; Kim, JT; Park, YH1
Goto, T; Mihara, T; Morita, S; Tojo, K; Uchimoto, K1
Baik, HJ; Do, SH; Han, JI; Hong, DM; Kim, HZ; Lee, JE; Lim, YJ; Min, KT; Park, HP; Ryu, JH1
Chai, WS; Cho, SH; Jin, HC; Kim, SH; Kim, YK; Lee, JH; Lee, SM; Park, SY1
Cao, G; Gao, C; Li, B; Lv, F; Wang, F; Wang, H; Wu, G; Xu, L1
Ahn, JS; Cho, YH; Jang, JS; Kang, JH; Kim, HJ; Kim, JS; Kim, SW; Kim, SY; Kim, YS; Ko, YH; Lee, HW; Lee, NR; Lee, SN; Lee, SR; Park, KU; Shin, SW; Song, EK; Yun, HJ1
Amagase, K; Horie, S; Kato, S; Matsumoto, K; Utsumi, D1
Choi, BM; Jeong, SW; Lee, EK; Lee, YH; Lim, YJ; Min, KT; Noh, GJ; Seo, JH1
Joo, J; Park, HJ; Park, S; Shin, SY1
Arora, MK; Borle, A; Gouda, D; Goudra, B; Makkar, JK; Singh, PM; Sinha, A; Trikha, A1
Abushouk, AI; Ahmed, H; Al Nahrawi, S; Attia, A; Awad, K; Elsherbeny, MY; Mustafa, SM1
Chaiwuttisak, A; Pinsornsak, P; Ruetiwarangkoon, C; Teeyaphudit, M1
Goto, T; Ka, K; Mihara, T; Yokoi, A1
Chen, Y; Deng, R; Li, Y; Ouyang, A; Zhou, J1
Kim, YS; Lee, HJ; Lee, SU1
Aizawa, F; Chuma, M; Goda, M; Hamano, H; Ishizawa, K; Izawa-Ishizawa, Y; Kanda, M; Murai, Y; Niimura, T; Okada, N; Yagi, K; Yoshida, A; Yoshioka, T; Zamami, Y1
Choi, SS; Kim, AR; Kim, H; Kim, YS; Lee, CH; Lee, MK; Oh, SK1

Reviews

8 review(s) available for ramosetron and ondansetron

ArticleYear
[A new antiemetic ramosetron hydrochloride].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24, Issue:3

    Topics: Animals; Antiemetics; Antineoplastic Agents; Benzimidazoles; Granisetron; Guinea Pigs; Humans; Male; Nausea; Ondansetron; Serotonin Antagonists; Vomiting

1997
Prevention of nausea and vomiting during termination of pregnancy.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2010, Volume: 111, Issue:1

    Topics: Abortion, Therapeutic; Antiemetics; Benzimidazoles; Dexamethasone; Dilatation and Curettage; Droperidol; Drug Therapy, Combination; Female; Humans; Hydroxyzine; Metoclopramide; Ondansetron; Postoperative Nausea and Vomiting; Pregnancy; Propofol; Randomized Controlled Trials as Topic

2010
Reevaluation of the effectiveness of ramosetron for preventing postoperative nausea and vomiting: a systematic review and meta-analysis.
    Anesthesia and analgesia, 2013, Volume: 117, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Benzimidazoles; Female; Humans; Male; Middle Aged; Odds Ratio; Ondansetron; Postoperative Nausea and Vomiting; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome; Young Adult

2013
Efficacy and safety of ramosetron versus ondansetron for postoperative nausea and vomiting after general anesthesia: a meta-analysis of randomized clinical trials.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Antiemetics; Benzimidazoles; Humans; Ondansetron; Postoperative Nausea and Vomiting; Randomized Controlled Trials as Topic

2015
Efficacy of palonosetron in postoperative nausea and vomiting (PONV)-a meta-analysis.
    Journal of clinical anesthesia, 2016, Volume: 34

    Topics: Adult; Anesthesia, General; Antiemetics; Benzimidazoles; Granisetron; Humans; Isoquinolines; Ondansetron; Palonosetron; Postoperative Nausea and Vomiting; Quinuclidines; Randomized Controlled Trials as Topic; Serotonin Antagonists; Treatment Outcome

2016
Dexamethasone combined with other antiemetics versus single antiemetics for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: An updated systematic review and meta-analysis.
    International journal of surgery (London, England), 2016, Volume: 36, Issue:Pt A

    Topics: Antiemetics; Benzimidazoles; Cholecystectomy, Laparoscopic; Dexamethasone; Drug Therapy, Combination; Granisetron; Humans; Isoquinolines; Metoclopramide; Ondansetron; Palonosetron; Postoperative Nausea and Vomiting; Quinuclidines; Randomized Controlled Trials as Topic

2016
Comparative efficacy of ramosetron and ondansetron in preventing postoperative nausea and vomiting: An updated systematic review and meta-analysis with trial sequential analysis.
    PloS one, 2017, Volume: 12, Issue:10

    Topics: Antiemetics; Benzimidazoles; Humans; Ondansetron; Postoperative Nausea and Vomiting

2017
Comparison of ramosetron and ondansetron for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: a meta-analysis of randomized controlled trials.
    The Journal of international medical research, 2019, Volume: 47, Issue:10

    Topics: Adult; Benzimidazoles; Humans; Laparoscopy; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Publication Bias; Randomized Controlled Trials as Topic; Risk

2019

Trials

17 trial(s) available for ramosetron and ondansetron

ArticleYear
[Effects of oral 5-HT3 antagonists on chemotherapy-induced emesis in patients with gynecologic cancers].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2000, Volume: 27, Issue:4

    Topics: Administration, Oral; Antiemetics; Benzimidazoles; Carboplatin; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Genital Neoplasms, Female; Granisetron; Humans; Indoles; Middle Aged; Nausea; Ondansetron; Paclitaxel; Serotonin Antagonists; Tropisetron; Vomiting

2000
[Effects of Nasea on prevention of gastrointestinal side effects caused by chemotherapeutic drugs].
    Zhonghua yi xue za zhi, 2003, Jul-10, Volume: 83, Issue:13

    Topics: Adult; Aged; Anorexia; Antiemetics; Antineoplastic Agents; Benzimidazoles; Female; Gastrointestinal Diseases; Humans; Injections, Intravenous; Male; Middle Aged; Nausea; Neoplasms; Ondansetron; Time Factors; Treatment Outcome; Vomiting

2003
Ramosetron versus ondansetron in the prevention of chemotherapy-induced gastrointestinal side effects: A prospective randomized controlled study.
    Chemotherapy, 2007, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Aged; Anorexia; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Female; Humans; Male; Middle Aged; Nausea; Neoplasms; Ondansetron; Vomiting

2007
Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron.
    Spine, 2008, Aug-01, Volume: 33, Issue:17

    Topics: Adolescent; Adult; Aged; Analgesia, Patient-Controlled; Benzimidazoles; Double-Blind Method; Female; Humans; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Prospective Studies; Spinal Diseases

2008
Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery.
    British journal of anaesthesia, 2009, Volume: 103, Issue:4

    Topics: Adult; Aged; Antiemetics; Benzimidazoles; Double-Blind Method; Female; Gynecologic Surgical Procedures; Humans; Intraoperative Care; Middle Aged; Ondansetron; Patient Satisfaction; Postoperative Nausea and Vomiting; Prospective Studies; Treatment Outcome; Young Adult

2009
Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.
    Surgical endoscopy, 2010, Volume: 24, Issue:4

    Topics: Adult; Aged; Analysis of Variance; Antiemetics; Benzimidazoles; Chi-Square Distribution; Cholecystectomy, Laparoscopic; Double-Blind Method; Female; Humans; Male; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Treatment Outcome

2010
Comparison of the prophylactic anti-emetic efficacy of ramosetron and ondansetron in patients at high-risk for postoperative nausea and vomiting after total knee replacement.
    Anaesthesia, 2010, Volume: 65, Issue:5

    Topics: Aged; Aged, 80 and over; Antiemetics; Arthroplasty, Replacement, Knee; Benzimidazoles; Female; Humans; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Severity of Illness Index; Treatment Outcome

2010
Prophylactic control of post-operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery.
    Acta anaesthesiologica Scandinavica, 2010, Volume: 54, Issue:8

    Topics: Aged; Analgesia, Patient-Controlled; Anesthesia; Antiemetics; Benzimidazoles; Cardiac Surgical Procedures; Double-Blind Method; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Ondansetron; Pain, Postoperative; Postoperative Care; Postoperative Nausea and Vomiting

2010
Comparison of ramosetron and ondansetron for control of post-operative nausea and vomiting following laparoscopic cholecystectomy.
    Indian journal of medical sciences, 2010, Volume: 64, Issue:6

    Topics: Adult; Antiemetics; Benzimidazoles; Cholecystectomy, Laparoscopic; Female; Humans; Male; Ondansetron; Postoperative Nausea and Vomiting

2010
Comparison of the efficacy of ramosetron and ondansetron in the prophylaxis of postoperative vomiting in children receiving fentanyl by patient-controlled analgesia after orthopedic surgery: a randomized controlled trial.
    Paediatric anaesthesia, 2013, Volume: 23, Issue:4

    Topics: Adolescent; Analgesia, Patient-Controlled; Analgesics, Opioid; Antiemetics; Benzimidazoles; Child; Child, Preschool; Double-Blind Method; Female; Fentanyl; Humans; Male; Ondansetron; Orthopedic Procedures; Pain, Postoperative; Postoperative Nausea and Vomiting

2013
A prospective, randomized, double-blind, and multicenter trial of prophylactic effects of ramosetronon postoperative nausea and vomiting (PONV) after craniotomy: comparison with ondansetron.
    BMC anesthesiology, 2014, Volume: 14

    Topics: Adult; Aged; Antiemetics; Benzimidazoles; Craniotomy; Double-Blind Method; Female; Humans; Male; Middle Aged; Ondansetron; Pain, Postoperative; Postoperative Nausea and Vomiting; Prospective Studies; Treatment Outcome; Young Adult

2014
Effects of prophylactic ramosetron and ondansetron on corrected QT interval during general anesthesia.
    Journal of clinical anesthesia, 2014, Volume: 26, Issue:7

    Topics: Adult; Aged; Anesthesia, General; Antiemetics; Benzimidazoles; Cholecystectomy, Laparoscopic; Dose-Response Relationship, Drug; Electrocardiography; Female; Humans; Long QT Syndrome; Male; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Young Adult

2014
Ramosetron Versus Ondansetron in Combination With Aprepitant and Dexamethasone for the Prevention of Highly Emetogenic Chemotherapy-Induced Nausea and Vomiting: A Multicenter, Randomized Phase III Trial, KCSG PC10-21.
    The oncologist, 2015, Volume: 20, Issue:12

    Topics: Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Aprepitant; Benzimidazoles; Dexamethasone; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Morpholines; Nausea; Neoplasms; Ondansetron; Prospective Studies; Single-Blind Method; Treatment Outcome; Vomiting

2015
Population pharmacokinetics and prophylactic anti-emetic efficacy of ramosetron in surgical patients.
    British journal of clinical pharmacology, 2016, Volume: 82, Issue:3

    Topics: Antiemetics; Benzimidazoles; Double-Blind Method; Female; Humans; Male; Middle Aged; Models, Biological; Ondansetron; Postoperative Nausea and Vomiting

2016
Ramosetron versus ondansetron for postoperative nausea and vomiting in strabismus surgery patients.
    BMC anesthesiology, 2016, 07-22, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Anesthesia, General; Antiemetics; Benzimidazoles; Double-Blind Method; Female; Humans; Incidence; Male; Middle Aged; Ondansetron; Patient Satisfaction; Postoperative Nausea and Vomiting; Prospective Studies; Strabismus; Time Factors; Treatment Outcome; Young Adult

2016
Comparison of Ramosetron With Ondansetron for Prevention of Intrathecal Morphine-Induced Nausea and Vomiting After Primary Total Knee Arthroplasty: A Randomized Control Trial.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:3

    Topics: Aged; Anesthesia, Spinal; Antiemetics; Arthroplasty, Replacement, Knee; Benzimidazoles; Cost-Benefit Analysis; Double-Blind Method; Female; Humans; Injections, Spinal; Male; Middle Aged; Morphine; Narcotics; Ondansetron; Pain Management; Patient Satisfaction; Postoperative Nausea and Vomiting; Receptors, Serotonin, 5-HT3

2017
The effectiveness of ramosetron and ondansetron for preventing postoperative nausea and vomiting after arthroscopic rotator cuff repair: a randomized controlled trial.
    Journal of orthopaedic surgery and research, 2020, Nov-11, Volume: 15, Issue:1

    Topics: Aged; Antiemetics; Arthroscopy; Benzimidazoles; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Ondansetron; Pain, Postoperative; Postoperative Nausea and Vomiting; Postoperative Period; Rotator Cuff; Severity of Illness Index; Time Factors; Treatment Outcome

2020

Other Studies

21 other study(ies) available for ramosetron and ondansetron

ArticleYear
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Animals; Cell Line; Disease Models, Animal; Humans; Imidazoles; Indoles; Irritable Bowel Syndrome; Mice; Microsomes, Liver; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Agonists

2011
Pharmacologic profile of (R)-5-[(1-methyl-3-indolyl)carbonyl]-4,5,6,7-tetrahydro-1H- benzimidazole hydrochloride (YM060), a potent and selective 5-hydroxytryptamine3 receptor antagonist, and its enantiomer in the isolated tissue.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 259, Issue:1

    Topics: Animals; Benzimidazoles; Dogs; Female; Granisetron; Guinea Pigs; Imidazoles; Indazoles; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Myocardial Contraction; Ondansetron; Receptors, Adrenergic; Receptors, Histamine; Serotonin Antagonists; Stereoisomerism

1991
Comparative study of the affinities of the 5-HT3 receptor antagonists, YM060, YM114 (KAE-393), granisetron and ondansetron in rat vagus nerve and cerebral cortex.
    Neuropharmacology, 1995, Volume: 34, Issue:6

    Topics: Animals; Benzimidazoles; Cerebral Cortex; Dose-Response Relationship, Drug; Electrophysiology; Granisetron; Kinetics; Male; Ondansetron; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Vagus Nerve

1995
Serotonin (5-HT)3-receptor antagonism of 4,5,6,7-tetrahydrobenzimidazole derivatives against 5-HT-induced bradycardia in anesthetized rats.
    Japanese journal of pharmacology, 1994, Volume: 65, Issue:3

    Topics: Animals; Benzimidazoles; Bradycardia; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Granisetron; Guinea Pigs; In Vitro Techniques; Indolizines; Injections, Intravenous; Male; Muscle Contraction; Muscle, Smooth; Ondansetron; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Structure-Activity Relationship

1994
Pharmacological properties of KF18259, a novel 5-HT3-receptor antagonist, in rats: inhibition of the distal colonic function.
    Japanese journal of pharmacology, 1993, Volume: 63, Issue:4

    Topics: Animals; Benzimidazoles; Cisplatin; Colon; Defecation; Gastric Emptying; Gastrointestinal Motility; Granisetron; Male; Ondansetron; Quinolines; Rats; Rats, Sprague-Dawley; Reflex; Serotonin; Serotonin Antagonists

1993
Effect of serotonin (5-HT)3-receptor antagonists YM060, YM114 (KAE-393), ondansetron and granisetron on 5-HT4 receptors and gastric emptying in rodents.
    Japanese journal of pharmacology, 1995, Volume: 69, Issue:3

    Topics: Animals; Benzimidazoles; Cisplatin; Dose-Response Relationship, Drug; Gastric Emptying; Granisetron; Guinea Pigs; Male; Ondansetron; Rats; Rats, Wistar; Serotonin Antagonists

1995
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4,5,6,7-tetrahydro-1H-benzimidazole derivatives.
    Chemical & pharmaceutical bulletin, 1996, Volume: 44, Issue:9

    Topics: Animals; Benzimidazoles; Cisplatin; Crystallography, X-Ray; Defecation; Ferrets; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Muscle Contraction; Ondansetron; Rats; Rats, Wistar; Serotonin Antagonists; Structure-Activity Relationship; Vomiting

1996
Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. IV. Synthesis and pharmacological evaluation of the oxidation products of (-)-(R)-5-[(1-methyl-1H-indol-3-yl)carbonyl] -4,5,6,7-tetrahydro-1H-benzimidazole hydrochloride (YM060: ramosetron).
    Chemical & pharmaceutical bulletin, 1996, Volume: 44, Issue:9

    Topics: Animals; Benzimidazoles; Colon; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Molecular Conformation; Muscle Contraction; Ondansetron; Oxidation-Reduction; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Structure-Activity Relationship

1996
Compounds possessing 5-HT3 receptor antagonistic activity inhibit intestinal propulsion in mice.
    European journal of pharmacology, 1996, Sep-05, Volume: 311, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Benzamides; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Cisapride; Clonidine; Gastrointestinal Transit; Intestines; Male; Mice; Mice, Inbred C57BL; Neostigmine; Ondansetron; Piperidines; Receptors, Serotonin; Serotonin Antagonists

1996
Effects of gastroprokinetic agents on gastroparesis in streptozotocin-induced diabetic rats.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:1

    Topics: Animals; Benzamides; Benzimidazoles; Blood Glucose; Cisapride; Diabetes Mellitus, Experimental; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Granisetron; Male; Morpholines; Ondansetron; Piperidines; Pyrroles; Rats; Rats, Wistar; Serotonin Antagonists; Serotonin Receptor Agonists; Vagotomy

1997
Effects of various 5-HT3 receptor antagonists, granisetron, ondansetron, ramosetron and azasetron on serotonin (5-HT) release from the ferret isolated ileum.
    Research communications in molecular pathology and pharmacology, 1999, Volume: 104, Issue:2

    Topics: Animals; Benzimidazoles; Dose-Response Relationship, Drug; Drug Interactions; Ferrets; Granisetron; Ileum; Male; Ondansetron; Receptors, Serotonin; Serotonin; Serotonin Antagonists

1999
Effects of ondansetron, granisetron, ramosetron, and azasetron on human neutrophil functions.
    Gynecologic and obstetric investigation, 2002, Volume: 53, Issue:2

    Topics: Antiemetics; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Chemotaxis, Leukocyte; Granisetron; Humans; Neutrophils; Ondansetron; Oxazines

2002
Effects of serotonin-3 receptor antagonists on cytochrome P450 activities in human liver microsomes.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:9

    Topics: Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Microsomes, Liver; Ondansetron; Oxazines; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists

2006
[Comparison of antiemetic efficacy of 5-HT3 receptor antagonists in orthopedics cancer patients receiving high-dose chemotherapy].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2007, Volume: 34, Issue:3

    Topics: Adolescent; Adult; Aged; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bone Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Granisetron; Humans; Ifosfamide; Male; Middle Aged; Nausea; Ondansetron; Osteosarcoma; Prospective Studies; Serotonin 5-HT3 Receptor Antagonists; Vomiting

2007
Ramosetron for the prevention of nausea and vomiting during 5-fluorouracil-based chemoradiotherapy for pancreatico-biliary cancer.
    Japanese journal of clinical oncology, 2009, Volume: 39, Issue:2

    Topics: Adult; Aged; Antiemetics; Benzimidazoles; Biliary Tract Neoplasms; Chemotherapy, Adjuvant; Female; Fluorouracil; Humans; Male; Metoclopramide; Middle Aged; Nausea; Ondansetron; Pancreatic Neoplasms; Radiotherapy, Adjuvant; Vomiting

2009
Receptor occupancy theory-based analysis of interindividual differences in antiemetic effects of 5-HT3 receptor antagonists.
    International journal of clinical oncology, 2009, Volume: 14, Issue:6

    Topics: Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Drug Administration Schedule; Granisetron; Humans; Indoles; Models, Theoretical; Ondansetron; Oxazines; Serotonin 5-HT3 Receptor Antagonists; Treatment Outcome; Tropisetron; Vomiting

2009
Matching groups for studying postoperative nausea and vomiting: should we care?
    Surgical endoscopy, 2010, Volume: 24, Issue:7

    Topics: Antiemetics; Benzimidazoles; Humans; Ondansetron; Postoperative Nausea and Vomiting; Risk Factors

2010
5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells.
    British journal of pharmacology, 2013, Volume: 168, Issue:6

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Benzimidazoles; Colonic Neoplasms; Cytokines; Diarrhea; Dose-Response Relationship, Drug; Drug Interactions; Fluorouracil; Gastrointestinal Agents; Gene Expression Regulation; Immunosuppressive Agents; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mucositis; Ondansetron; Serotonin 5-HT3 Receptor Agonists; Serotonin 5-HT3 Receptor Antagonists

2013
5-HT3 receptors promote colonic inflammation via activation of substance P/neurokinin-1 receptors in dextran sulphate sodium-induced murine colitis.
    British journal of pharmacology, 2016, Volume: 173, Issue:11

    Topics: Animals; Benzimidazoles; Colitis; Colon; Dextran Sulfate; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Mice, Inbred C57BL; Ondansetron; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Structure-Activity Relationship; Substance P

2016
Effects of 5-HT
    Clinical and translational science, 2021, Volume: 14, Issue:5

    Topics: Acute Kidney Injury; Aged; Animals; Benzimidazoles; Cisplatin; Disease Models, Animal; Female; Granisetron; Humans; Kidney; Male; Mice; Middle Aged; Nausea; Ondansetron; Organic Cation Transport Proteins; Palonosetron; Renal Elimination; Retrospective Studies; Serotonin 5-HT3 Receptor Antagonists; Vomiting

2021
Microbiological and Physicochemical Stability of Fentanyl, Oxycodone, Hydromorphone, Ketorolac, Ramosetron, and Ondansetron for Intravenous Patient-controlled Analgesia: An In Vitro Study.
    Pain physician, 2021, Volume: 24, Issue:6

    Topics: Analgesia, Patient-Controlled; Analgesics, Opioid; Benzimidazoles; Fentanyl; Humans; Hydromorphone; Ketorolac; Ondansetron; Oxycodone; Pain, Postoperative

2021