ramatroban has been researched along with prostaglandin d2 in 28 studies
| Studies (ramatroban) | Trials (ramatroban) | Recent Studies (post-2010) (ramatroban) | Studies (prostaglandin d2) | Trials (prostaglandin d2) | Recent Studies (post-2010) (prostaglandin d2) |
|---|---|---|---|---|---|
| 142 | 10 | 28 | 3,454 | 78 | 751 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (25.00) | 18.2507 |
| 2000's | 15 (53.57) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bacon, KB; Encinas, JA; Gantner, F; Inbe, H; Nagao, K; Shichijo, M; Sugimoto, H; Takeshita, K | 1 |
| Breyer, RM; Hata, AN; Lybrand, TP | 1 |
| Bacon, KB; Okano, M; Shichijo, M; Sugimoto, H | 1 |
| Bardin, PG; Harrison, J; Holgate, ST; Johnston, SL; Joubert, JR; Ritter, W | 1 |
| Baunack, AR; Boerger, S; Magnussen, H; Templin, K | 1 |
| Francis, HP; Gardiner, PJ; Greenham, SJ; Patel, UP; Thompson, AM | 1 |
| Francis, HP; Gardiner, PJ; Morris, TG; Patel, UP; Thompson, AM | 1 |
| Cuthbert, NJ; Gardiner, PJ; McKenniff, MG; Norman, P | 1 |
| Freezer, NJ; Howarth, PH; Johnston, SL; O'Toole, S; Ritter, W | 1 |
| Harrison, J; Howarth, PH; Johnston, SL; Ritter, W; Smith, S | 1 |
| Bacon, KB; Gantner, F; Iino, T; Manabe, Y; Shichijo, M; Shimazaki, M; Sugimoto, H; Watanabe, A | 1 |
| Böhm, E; Heinemann, A; Kollroser, M; McNamee, A; Pease, JE; Peskar, BA; Sandig, H; Shichijo, M; Sturm, GJ; Weiglhofer, I | 1 |
| Bacon, KB; Gantner, F; Nagao, K; Shichijo, M; Sugimoto, H; Takeshita, K; Yamasaki, T | 1 |
| Gazi, L; Gyles, SL; Hunter, MG; Pettipher, R; Townsend, E; Wettey, FR; Xue, L | 1 |
| Dogné, JM; Masereel, B; Rolin, S | 1 |
| Heinemann, A; Lippe, IT; Peskar, BA; Royer, JF; Schratl, P; Sturm, EM; Sturm, GJ | 1 |
| Gyles, SL; Pettipher, R; Townsend, ER; Wettey, F; Xue, L | 1 |
| Ago, J; Inoue, T; Ishikawa, T; Kamei, C; Rahman, A | 1 |
| Pettipher, R; Townsend, ER; Vinall, SL | 1 |
| Fujiwara, T; Hara, T; Hirai, H; Kimura, Y; Kino, K; Maeda, M; Nagata, K; Nakamura, M; Nishizaki, K; Nomiya, R; Okano, M; Yokoyama, M | 1 |
| Barker, J; Beri, R; Carrillo, JJ; Heinemann, A; Jupp, R; Lang-Loidolt, D; Royer, JF; Sargent, C; Schmidt, JA; Schratl, P; Weyman-Jones, C | 1 |
| Whelan, CJ | 1 |
| Bachert, C; Holtappels, G; Pérez-Novo, CA; Pettipher, R; Vinall, SL; Xue, L; Zhang, N | 1 |
| Hu, Y; Lou, HQ; Ying, YF | 1 |
| Mak, OT; Wang, JJ | 1 |
| Hirano, Y; Hirayama, Y; Kobayashi, M; Matsuda, H; Miyao, Y; Nakazato, S; Numazaki, M; Shimizu, Y; Tasaki, M; Tenda, Y; Terasaka, T; Tsujimoto, S | 1 |
| Ahmad, M; Graham, SH; Hickey, RW; Li, W; Liu, H; Miller, TM; Pascoe, JL; Poloyac, SM; Rose, ME | 1 |
| Wu, X; Yu, S; Zhang, S | 1 |
1 review(s) available for ramatroban and prostaglandin d2
| Article | Year |
|---|---|
Prostanoids as pharmacological targets in COPD and asthma.
Topics: Animals; Asthma; Benzoquinones; Carbazoles; Enzyme Inhibitors; F2-Isoprostanes; Heptanoic Acids; Humans; Methacrylates; Prostaglandin Antagonists; Prostaglandin D2; Pulmonary Disease, Chronic Obstructive; Randomized Controlled Trials as Topic; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; Sulfonamides; Thromboxane A2; Thromboxane-A Synthase | 2006 |
4 trial(s) available for ramatroban and prostaglandin d2
| Article | Year |
|---|---|
The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Carbazoles; Female; Histamine; Histamine Antagonists; Humans; Male; Middle Aged; Prostaglandin D2; Respiratory Function Tests; Sulfonamides; Thromboxanes | 1992 |
Effects of a thromboxane-receptor antagonist, BAY u 3405, on prostaglandin D2- and exercise-induced bronchoconstriction.
Topics: Air; Airway Resistance; Asthma, Exercise-Induced; Bronchial Provocation Tests; Bronchoconstriction; Carbazoles; Cold Temperature; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Forced Expiratory Volume; Humans; Male; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxanes; Time Factors | 1992 |
Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor.
Topics: Adult; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Carbazoles; Double-Blind Method; Forced Expiratory Volume; Humans; Male; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Thromboxanes | 1995 |
The effect of BAY u 3405, a thromboxane receptor antagonist, on prostaglandin D2-induced nasal blockage.
Topics: Adult; Aged; Airway Resistance; Carbazoles; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Middle Aged; Nasal Provocation Tests; Nose; Prostaglandin D2; Receptors, Thromboxane; Rhinitis, Allergic, Perennial; Sulfonamides | 1993 |
23 other study(ies) available for ramatroban and prostaglandin d2
| Article | Year |
|---|---|
Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.
Topics: Amino Acid Sequence; Animals; Base Sequence; Bone Marrow; Carbazoles; Cloning, Molecular; Eosinophilia; Humans; Leukocyte Count; Leukocytes; Mice; Molecular Sequence Data; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Sequence Homology, Amino Acid; Sulfonamides; Th2 Cells | 2003 |
Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Cell Movement; Chemotactic Factors; Chemotaxis; Cyclic AMP; Dose-Response Relationship, Drug; Eicosanoids; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glutamic Acid; Humans; Hypersensitivity; Indomethacin; Inflammation; Kinetics; Ligands; Mice; Models, Biological; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Prostaglandins; Protein Binding; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Prostaglandin; Tyrosine | 2005 |
CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Carbazoles; Cell Line; Cell Movement; Cyclic AMP; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Hydrazines; Indomethacin; Models, Biological; Pentanoic Acids; Prostaglandin D2; Pyridines; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Transfection; Tritium | 2005 |
BAY u3405 an antagonist of thromboxane A2- and prostaglandin D2-induced bronchoconstriction in the guinea-pig.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Administration, Oral; Aerosols; Animals; Blood Pressure; Bronchoconstriction; Carbazoles; Guinea Pigs; Histamine; In Vitro Techniques; Injections, Intravenous; Male; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Serotonin; SRS-A; Sulfonamides; Thromboxane A2; Thromboxanes | 1991 |
The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig.
Topics: Animals; Bronchoconstriction; Carbazoles; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lung Volume Measurements; Male; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Thromboxane; Sotalol; Sulfonamides; Thromboxanes | 1991 |
BAY u3405 is a potent and competitive antagonist of U46619, PGD2 and 9 alpha, 11 beta PGF2 alpha-induced contractions of airway smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbazoles; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Sulfonamides; Thromboxanes; Trachea | 1991 |
An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro.
Topics: Administration, Oral; Biological Availability; Calcium; Carbazoles; Cell Movement; Drug Interactions; Eosinophils; Humans; In Vitro Techniques; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Transfection | 2003 |
11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Basophils; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Carbazoles; Cell Size; Chemotaxis, Leukocyte; Enzyme Inhibitors; Eosinophils; Fatty Acids, Unsaturated; Flow Cytometry; Humans; Hydrazines; Pertussis Toxin; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Thromboxane B2; Transfection; Type C Phospholipases | 2004 |
CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation.
Topics: Animals; Carbazoles; Chemokine CXCL1; Chemokines; Chemokines, CXC; Cytokines; Dermatitis, Allergic Contact; Dermatitis, Atopic; Eosinophils; Female; Inflammation; Leukotriene B4; Mice; Mice, Inbred BALB C; Neutrophil Activation; Neutrophils; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Signal Transduction; Sulfonamides; Th2 Cells | 2004 |
Prostaglandin D2 causes preferential induction of proinflammatory Th2 cytokine production through an action on chemoattractant receptor-like molecule expressed on Th2 cells.
Topics: Base Sequence; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cells, Cultured; Cytokines; DNA; Fatty Acids, Unsaturated; Humans; Hydantoins; Hydrazines; Inflammation; Inflammation Mediators; Interleukin-13; Interleukin-4; Interleukin-5; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Th2 Cells; Up-Regulation | 2005 |
Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase.
Topics: Arachidonic Acids; Carbazoles; Chemokine CCL11; Chemokines, CC; Chemotactic Factors, Eosinophil; Chemotaxis, Leukocyte; Eosinophils; Humans; p38 Mitogen-Activated Protein Kinases; Platelet Aggregation Inhibitors; Prostaglandin D2; Sulfonamides | 2006 |
A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ Th2 lymphocytes in response to mast cell supernatants.
Topics: Carbazoles; Cells, Cultured; Chemotaxis, Leukocyte; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Immunologic; Humans; Immunoglobulin E; Lymphocyte Activation; Mast Cells; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; Th2 Cells | 2006 |
Interactive effect of histamine and prostaglandin D2 on nasal allergic symptoms in rats.
Topics: Administration, Intranasal; Administration, Oral; Animals; Carbazoles; Chlorpheniramine; Cyproheptadine; Dose-Response Relationship, Drug; Drug Synergism; Histamine; Histamine Agents; Histamine H1 Antagonists; Hydantoins; Injections, Intravenous; Nasal Mucosa; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis; Sneezing; Sulfonamides | 2007 |
A paracrine role for chemoattractant receptor-homologous molecule expressed on T helper type 2 cells (CRTH2) in mediating chemotactic activation of CRTH2+ CD4+ T helper type 2 lymphocytes.
Topics: Carbazoles; CD28 Antigens; CD3 Complex; Cells, Cultured; Chemotaxis, Leukocyte; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Cytokines; Diclofenac; Humans; Lymphocyte Activation; Paracrine Communication; Prostaglandin D2; Receptors, Formyl Peptide; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Th2 Cells | 2007 |
CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice.
Topics: Allergens; Animals; Antigens, Plant; Carbazoles; Cryptomeria; Cytokines; Disease Models, Animal; Eosinophils; Immunoglobulins; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Nasal Mucosa; Nasal Septum; Plant Proteins; Pollen; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Rhinitis, Allergic, Seasonal; Sulfonamides; Th2 Cells | 2008 |
A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils.
Topics: Animals; Basophils; Bone Marrow; Carbazoles; Cell Movement; Chemotaxis; Guinea Pigs; Humans; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Th2 Cells | 2008 |
Evidence that 13-14 di-hydro, 15-keto prostaglandin D(2)-induced airway eosinophilia in guinea-pigs is independent of interleukin-5.
Topics: Animals; Carbazoles; Eosinophilia; Female; Guinea Pigs; Humans; Interleukin-5; Lung; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides | 2009 |
CRTH2 mediates the activation of human Th2 cells in response to PGD(2) released from IgE/anti-IgE treated nasal polyp tissue.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Anti-Idiotypic; Carbazoles; Chemotaxis, Leukocyte; Diclofenac; Humans; Immunoglobulin E; Lymphocyte Activation; Mast Cells; Nasal Polyps; Platelet Aggregation Inhibitors; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Th2 Cells | 2010 |
[CRTH2 antagonist ameliorates airway inflammation in rats with asthma].
Topics: Animals; Asthma; Bronchi; Carbazoles; Inflammation; Male; Ovalbumin; Prostaglandin D2; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides | 2010 |
Induction of apoptosis in non-small cell lung carcinoma A549 cells by PGD₂ metabolite, 15d-PGJ₂.
Topics: Apoptosis; Carbazoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Cytochromes c; Cytosol; DNA Fragmentation; Humans; Hydantoins; Mitochondria; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides | 2011 |
Inhibition of antigen-induced airway inflammation and hyperresponsiveness in guinea pigs by a selective antagonist of "chemoattractant receptor homologous molecule expressed on Th2 cells" (CRTH2).
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Antigens; Benzhydryl Compounds; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Carbazoles; Cell Count; Eosinophilia; Guinea Pigs; HEK293 Cells; Humans; K562 Cells; Male; Ovalbumin; Pneumonia; Prostaglandin D2; Pyridazines; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides | 2013 |
Prostaglandin D2 toxicity in primary neurons is mediated through its bioactive cyclopentenone metabolites.
Topics: Animals; Apoptosis; Carbazoles; Cells, Cultured; Cerebral Cortex; Cyclopentanes; Dose-Response Relationship, Drug; Embryo, Mammalian; Hypoxia; Intramolecular Oxidoreductases; Lipocalins; Mice; Mice, Knockout; Neurons; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Sulfonamides | 2013 |
Prostaglandin D2 receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus.
Topics: Animals; Carbazoles; Cell Movement; Eosinophil Major Basic Protein; Eosinophilic Esophagitis; Eosinophils; Epithelium; Esophagus; Guinea Pigs; Hydantoins; Male; Mast Cells; Ovalbumin; Prostaglandin Antagonists; Prostaglandin D2; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides | 2014 |