Page last updated: 2024-09-03

ramatroban and indomethacin

ramatroban has been researched along with indomethacin in 9 studies

Compound Research Comparison

Studies
(ramatroban)
Trials
(ramatroban)
Recent Studies (post-2010)
(ramatroban)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
142102829,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyramatroban (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's4 (44.44)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Breyer, RM; Hata, AN; Lybrand, TP1
Bacon, KB; Okano, M; Shichijo, M; Sugimoto, H1
Board, PG; Christ, AN; Clark, AG; Flanagan, JU; Hall, R; Hayes, JD; Hume, DA; Oakley, AJ; Smythe, ML; Weber, JE1
Barton, P; Luker, T; Wenlock, MC1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Francis, HP; Gardiner, PJ; Morris, TG; Patel, UP; Thompson, AM1
Diener, M; Schultheiss, G1
Fuse, E; Ikemura, T; Karasawa, A; Kotera, O; Manabe, H; Mimura, H; Miyaji, H; Ohshima, E; Sawada, M; Tashiro, S; Ueno, K1
Jiang, S; Kamei, C; Rahman, A; Ueda, Y; Yatsuzuka, R1

Other Studies

9 other study(ies) available for ramatroban and indomethacin

ArticleYear
Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.
    The Journal of biological chemistry, 2005, Sep-16, Volume: 280, Issue:37

    Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Cell Line; Cell Movement; Chemotactic Factors; Chemotaxis; Cyclic AMP; Dose-Response Relationship, Drug; Eicosanoids; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glutamic Acid; Humans; Hypersensitivity; Indomethacin; Inflammation; Kinetics; Ligands; Mice; Models, Biological; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Prostaglandins; Protein Binding; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Receptors, Immunologic; Receptors, Prostaglandin; Tyrosine

2005
CRTH2-specific binding characteristics of [3H]ramatroban and its effects on PGD2-, 15-deoxy-Delta12, 14-PGJ2- and indomethacin-induced agonist responses.
    European journal of pharmacology, 2005, Nov-07, Volume: 524, Issue:1-3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Carbazoles; Cell Line; Cell Movement; Cyclic AMP; Dose-Response Relationship, Drug; Fatty Acids, Unsaturated; Humans; Hydrazines; Indomethacin; Models, Biological; Pentanoic Acids; Prostaglandin D2; Pyridines; Receptors, Immunologic; Receptors, Prostaglandin; Sulfonamides; Transfection; Tritium

2005
Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D2 synthase.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Binding Sites; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione Transferase; Hematopoiesis; Humans; Intramolecular Oxidoreductases; Lipocalins; Models, Molecular; Molecular Conformation; Nocodazole

2010
Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Acids; Albumins; Drug Design; Humans; Hydrogen-Ion Concentration; Lipids; Molecular Structure; Pharmaceutical Preparations; Protein Binding

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The thromboxane receptor antagonist BAY u3405 reverses prostaglandin D2 (PGD2)-induced bronchoconstriction in the anaesthetised guinea pig.
    Annals of the New York Academy of Sciences, 1991, Volume: 629

    Topics: Animals; Bronchoconstriction; Carbazoles; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Lung Volume Measurements; Male; Prostaglandin D2; Receptors, Prostaglandin; Receptors, Thromboxane; Sotalol; Sulfonamides; Thromboxanes

1991
Inhibition of spontaneous smooth muscle contractions in rat and rabbit intestine by blockers of the thromboxane A2 pathway.
    Zentralblatt fur Veterinarmedizin. Reihe A, 1999, Volume: 46, Issue:2

    Topics: Animals; Benzimidazoles; Benzoxepins; Carbachol; Carbazoles; Colon; Female; In Vitro Techniques; Indomethacin; Intestine, Small; Isometric Contraction; Male; Masoprocol; Muscle, Smooth; Rabbits; Rats; Rats, Wistar; Receptors, Thromboxane; Sulfonamides; Thromboxane A2

1999
Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Calcium; Carbazoles; Cell Line; Cell Movement; Chemotaxis, Leukocyte; Cyclooxygenase Inhibitors; Eosinophils; Genetic Vectors; Humans; Indomethacin; Ligands; Platelet Aggregation Inhibitors; Prostaglandins D; Quinolines; Receptors, Immunologic; Receptors, Prostaglandin; Receptors, Thromboxane; Sulfonamides; T-Lymphocytes, Helper-Inducer

2005
Involvement of cyclooxygenase-2 in allergic nasal inflammation in rats.
    International immunopharmacology, 2006, Volume: 6, Issue:11

    Topics: Animals; Carbazoles; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Electroencephalography; Etodolac; Hypersensitivity; Indoles; Indomethacin; Leukotriene Antagonists; Male; Olfactory Bulb; Ovalbumin; Phenylcarbamates; Rats; Rats, Wistar; Receptors, Thromboxane A2, Prostaglandin H2; Rhinitis; Sneezing; Sulfonamides; Tosyl Compounds

2006