Page last updated: 2024-08-23

raloxifene hydrochloride and ly 353381

raloxifene hydrochloride has been researched along with ly 353381 in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (4.35)18.2507
2000's15 (65.22)29.6817
2010's7 (30.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Adrian, MD; Bryant, HU; Rowley, E; Sato, M; Turner, CH; Wang, T1
Galid, A; Kubista, E; Seifert, M1
Elit, L; Hirte, H1
Gajdos, C; Jordan, VC1
Bethea, CL; Michelson, D; Mirkes, SJ; Su, A1
Chan, S1
Cox, DA; Hurn, PD; Littleton-Kearney, MT; Ostrowski, NL; Rossberg, MI1
Fried, A; Segev, E; Wientroub, S; Zeitlin, L1
Sporn, MB1
David, E; Fournier dit Chabert, J; Lemaire, M; Pellet-Rostaing, S; Perrin, J1
Johansen, AM1
Bolton, JL; Liu, H; Qin, Z; Thatcher, GR1
Asghodom, RT; Bolton, JL; Frasor, J; Kastrati, I; Lantvit, DD; Overk, CR; Peng, KW; Qin, Z; Thatcher, GR1
Bolton, JL; Dietz, BM; Dunlap, T; Kastrati, I; Lantvit, DD; Overk, CR; Qin, Z; Thatcher, GR; Yao, P; Yu, B1
Bolton, JL; Edirisinghe, P; Qin, Z; Thatcher, GR; Wijewickrama, GT; Yu, B1
Cox, DA; Downs, RW; Dowsett, SA; Ghosh, A; Harper, K; Moffett, AM1
Lewiecki, EM1
Alam, J; Cox, DA; Dowsett, SA; Kendler, DL; Palacios, S; Stock, J; Zanchetta, J1
Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H1
Alam, J; Bhattoa, HP; Cox, DA; Dowsett, SA; Goldstein, SR; Muram, D; Neven, P; Sipos, A1
Bolton, JL; Chandrasena, ER; Choi, J; Edirisinghe, PD; Hemachandra, LP; Kastrati, I; Thatcher, GR; Wang, YT1
Cuzick, J; Sestak, I1
Briarava, M; Mocellin, S; Nitti, D; Pilati, P1

Reviews

9 review(s) available for raloxifene hydrochloride and ly 353381

ArticleYear
Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer.
    Current opinion in obstetrics & gynecology, 2002, Volume: 14, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Neoplasm Staging; Phosphoric Monoester Hydrolases; Piperidines; Progestins; PTEN Phosphohydrolase; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Survival Rate; Thiophenes; Tumor Suppressor Proteins

2002
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.
    Clinical breast cancer, 2002, Volume: 2, Issue:4

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome

2002
A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer.
    Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 11

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Endometrial Neoplasms; Estradiol; Female; Fulvestrant; Humans; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes

2002
Selective estrogen receptor modulators: tissue actions and potential for CNS protection.
    CNS drug reviews, 2002,Fall, Volume: 8, Issue:3

    Topics: Animals; Breast Neoplasms; Cardiovascular System; Central Nervous System; Cognition; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Receptors, Neurotransmitter; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus

2002
Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Aug-15, Volume: 10, Issue:16

    Topics: Anticarcinogenic Agents; Breast Neoplasms; Female; Humans; Molecular Structure; Neoplasm Staging; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes

2004
Breast cancer chemoprevention: a review of selective estrogen receptor modulators.
    Clinical journal of oncology nursing, 2005, Volume: 9, Issue:3

    Topics: Breast Neoplasms; Female; Humans; Piperidines; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes

2005
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis.
    Journal of women's health (2002), 2009, Volume: 18, Issue:10

    Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Parathyroid Hormone; Piperidines; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Vitamin D; Women's Health

2009
Preventive therapy for breast cancer: a consensus statement.
    The Lancet. Oncology, 2011, Volume: 12, Issue:5

    Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles

2011
Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials.
    Journal of the National Cancer Institute, 2016, Volume: 108, Issue:2

    Topics: Adult; Aged; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Norpregnenes; Piperidines; Postmenopause; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes

2016

Trials

3 trial(s) available for raloxifene hydrochloride and ly 353381

ArticleYear
Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010, Volume: 21, Issue:7

    Topics: Aged; Biomarkers; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Humans; Lipids; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Vasomotor System

2010
Arzoxifene versus raloxifene: effect on bone and safety parameters in postmenopausal women with osteoporosis.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012, Volume: 23, Issue:3

    Topics: Absorptiometry, Photon; Aged; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Double-Blind Method; Female; Femur Neck; Hip Joint; Hot Flashes; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Thiophenes; Treatment Outcome

2012
Gynecologic effects of arzoxifene in postmenopausal women with osteoporosis or low bone mass.
    Menopause (New York, N.Y.), 2012, Volume: 19, Issue:1

    Topics: Aged; Aged, 80 and over; Endometrial Neoplasms; Endometrium; Female; Genital Diseases, Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Polyps; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Uterine Hemorrhage; Vaginitis; Vulvitis

2012

Other Studies

11 other study(ies) available for raloxifene hydrochloride and ly 353381

ArticleYear
LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 287, Issue:1

    Topics: Animals; Biomechanical Phenomena; Body Weight; Bone and Bones; Cholesterol; Estrogen Antagonists; Female; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes; Uterus

1998
The oestrogen receptor and its selective modulators in gynaecological oncology.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36 Suppl 4

    Topics: Antineoplastic Agents, Hormonal; Cinnamates; Estrogen Antagonists; Female; Genital Neoplasms, Female; Humans; Norpregnenes; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Thiophenes; Toremifene

2000
Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques.
    Psychoneuroendocrinology, 2002, Volume: 27, Issue:4

    Topics: Animals; Carrier Proteins; Estradiol; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Gene Expression; Macaca mulatta; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Piperidines; Raloxifene Hydrochloride; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Estrogen Receptor Modulators; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Tryptophan Hydroxylase

2002
Effects of long-term administration of N-3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice.
    Journal of cellular biochemistry, 2003, Oct-01, Volume: 90, Issue:2

    Topics: Adipose Tissue; Animals; Body Weight; Bone Marrow Cells; Cholesterol; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Female; Fish Oils; Hypolipidemic Agents; Interleukin-1; Interleukin-10; Interleukin-6; Mice; Mice, Inbred BALB C; Ovariectomy; Ovary; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Skin; Spleen; Thiophenes; Triglycerides; Tumor Necrosis Factor-alpha

2003
Efficient access to 2-aryl-3-substituted benzo[b]thiophenes.
    The Journal of organic chemistry, 2005, Apr-29, Volume: 70, Issue:9

    Topics: Cyclization; Molecular Structure; Oxidation-Reduction; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes

2005
Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
    Chemical research in toxicology, 2007, Volume: 20, Issue:11

    Topics: Alkylation; Animals; Catalysis; Female; Glutathione; Horseradish Peroxidase; Indolequinones; Microsomes; Piperidines; Quinones; Raloxifene Hydrochloride; Rats; Selective Estrogen Receptor Modulators; Thiophenes; Uterus

2007
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
    ChemMedChem, 2007, Volume: 2, Issue:10

    Topics: Animals; Female; Lipids; Organ Size; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes; Uterus

2007
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
    Molecular cancer therapeutics, 2007, Volume: 6, Issue:9

    Topics: Animals; Antioxidants; Breast Neoplasms; Carcinoma, Hepatocellular; Chemoprevention; Female; Humans; Liver; Liver Neoplasms; Luciferases; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Peroxides; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Cells, Cultured

2007
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
    Bioconjugate chemistry, 2009, Volume: 20, Issue:4

    Topics: Animals; Azides; Biotinylation; Cell Extracts; Cell Line, Tumor; Hepatocytes; Indicators and Reagents; Ligands; Mass Spectrometry; Oxidation-Reduction; Piperidines; Proteins; Quinones; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Staining and Labeling; Thiophenes; Xenobiotics

2009
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Breast; Catechols; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA Adducts; Enzyme Induction; Epithelial Cells; Estrogens; Female; Histone Deacetylase Inhibitors; Horses; Humans; Oxidation-Reduction; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes

2011
Preventive therapy for breast cancer.
    Current oncology reports, 2012, Volume: 14, Issue:6

    Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Meta-Analysis as Topic; Middle Aged; Piperidines; Preventive Medicine; Pyrrolidines; Raloxifene Hydrochloride; Receptor, ErbB-2; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes

2012