raloxifene hydrochloride has been researched along with afimoxifene in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.38) | 18.7374 |
| 1990's | 6 (12.77) | 18.2507 |
| 2000's | 21 (44.68) | 29.6817 |
| 2010's | 17 (36.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Halleux, C; Kallen, J; Keller, H; Renaud, J; Schlaeppi, JM; Stark, W | 1 |
| Aikens, C; Eyunni, SVK; Hansberry, TD; Mateeva, N; Nag, A; Ononuju, U; Redda, KK | 1 |
| Dufour, JM; Labrie, F; Levesque, C; Merand, Y; Poirier, D; Poulin, R | 1 |
| Jordan, VC | 1 |
| Green, LR; Newboult, E; Valcaccia, B; Wakeling, AE | 1 |
| Clemm, DL; Goldman, ME; Hermann, T; McDonnell, DP; Pike, JW | 1 |
| Fournier, B; Häring, S; Kaye, AM; Sömjen, D | 1 |
| Logie, C; Nichols, M; Rientjes, JM; Stewart, AF | 1 |
| Jordan, VC; Kwaan, HC; Levenson, AS; Svoboda, KM | 1 |
| Funder, JW; Logie, C; Myles, K; Nichols, M; Stewart, AF | 1 |
| Christensen, DJ; Fowlkes, DM; McDonnell, DP; Nagel, SC; Norris, JD; Paige, LA; Wijayaratne, AL | 1 |
| Bentrem, DJ; Jordan, VC; Liu, H; MacGregor Schafer, J; Zapf, JW | 1 |
| Fisher, PW; Gowen, M; Nadeau, DP; Nuttall, ME; Stroup, GB; Suva, LJ | 1 |
| Deb Los Reyes, A; Jordan, VC; Lee, ES; Liu, H; Zapf, JW | 1 |
| Feher, M; Labute, P; Schmidt, JM; Sourial, E; Williams, C | 1 |
| Bentrem, DJ; Jordan, VC; Liu, H; Loweth, JA; McKian, KP; Park, WC; Reyes, Ade L; Schafer, JM; Zapf, JW | 1 |
| Aliau, S; Bonnafous, JC; Borgna, JL; Mattras, H; Richard, E | 1 |
| Burd, CJ; Feng, Y; Khan, SA; Singleton, DW | 1 |
| Bianco, NR; Montano, MM; Perry, G; Smith, MA; Templeton, DJ | 1 |
| Abrams, J; Deighton-Collins, S; Koide, A; Koide, S; Martinez, A; Schwartz, JA; Skafar, DF; Zhao, C | 1 |
| Lonard, DM; O'Malley, BW; Tsai, SY | 1 |
| Balaguer, P; Bonnet, S; Cavaillès, V; Duong, V; Escande, A; Margueron, R; Vignon, F | 1 |
| Flaig, R; Greschik, H; Moras, D; Renaud, JP | 1 |
| Benjamins, JA; Deighton-Collins, S; Guzmán, CB; Kleerekoper, M; Martinez, A; Skafar, DF; Zhao, C | 1 |
| Falany, CN; Falany, JL; Leyh, TS; Pilloff, DE | 1 |
| Leitão, A; Menezes, IR; Montanari, CA | 1 |
| Clarke, R; Dai, P; Lou, MA; Lu, JF; Nazarov, V; Wong, LJ | 1 |
| Knox, AS; Lloyd, DG; Meegan, MJ; O'Sullivan, T; Smith, HM; Zisterer, DM | 1 |
| Asselin, E; Bélanger, G; Boucher, V; Déry, MC; Leblanc, K; Parent, S; Sexton, E | 1 |
| Altobelli, G; Biglia, N; Cicatiello, L; Cimino, D; De Bortoli, M; Friard, O; Fuso, L; Ponzone, R; Ravo, M; Scafoglio, C; Sismondi, P; Weisz, A | 1 |
| Nose, T; Shimohigashi, Y; Tokunaga, T | 1 |
| Imai, M; Kanzaki, H; Nakajima, T; Okada, H; Tsutsumi, A; Yasuda, K | 1 |
| Goldstein, RE; Klinge, CM; Kumar, A | 1 |
| Boudot, A; Flouriot, G; Habauzit, D; Kerdivel, G; Pakdel, F | 1 |
| Ashcroft, FJ; Jones, ED; Mancini, MA; Mikic, I; Newberg, JY | 1 |
| Cooperwood, JS; Khan, MO; Musa, MA; Rahman, T | 1 |
| Cheong, SJ; Jang, D; Jeong, HJ; Katzenellenbogen, JA; Kim, DW; Lim, ST; Sohn, MH | 1 |
| Gambhir, SS; Katzenellenbogen, JA; Massoud, TF; Paulmurugan, R; Tamrazi, A | 1 |
| Klinge, CM; Mattingly, KA | 1 |
| Hoffman, KL; Lerner, SP; Smith, CL | 1 |
| Asp, ML; Martindale, JJ; Metzger, JM | 1 |
| Bolton, JL; Chandrasena, RE; Choi, J; Hemachandra, LP; Michalsen, BT; Patel, H; Piyankarage, SC; Scism, RA; Siklos, MI; Thatcher, GR; Thayer, EN; Wang, S; Wang, Y; Xiong, R | 1 |
| Blake, C; Lucic, A | 1 |
| Hui, Y; Kurogi, K; Liu, MC; Luo, L; Sakakibara, Y; Suiko, M; Zhang, L; Zhou, C | 1 |
| Cazzulino, AS; Denny, CA; Martinez, R; Tomm, NK | 1 |
| Burdette, JE; Davis, DA; Dean, M; Moyle-Heyrman, G; Schipma, MJ | 1 |
| Foygel, K; Gambhir, SS; Massoud, TF; Paulmurugan, R; Sekar, TV | 1 |
1 review(s) available for raloxifene hydrochloride and afimoxifene
| Article | Year |
|---|---|
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes | 1983 |
46 other study(ies) available for raloxifene hydrochloride and afimoxifene
| Article | Year |
|---|---|
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands.
Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Division; Crystallography, X-Ray; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; HeLa Cells; Humans; Isoquinolines; Ligands; Models, Molecular; Radioligand Assay; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured | 2003 |
Functional evaluation of synthetic flavonoids and chalcones for potential antiviral and anticancer properties.
Topics: Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Chalcones; Flavonoids; Humans; Structure-Activity Relationship | 2017 |
Antiestrogenic properties of keoxifene, trans-4-hydroxytamoxifen, and ICI 164384, a new steroidal antiestrogen, in ZR-75-1 human breast cancer cells.
Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Dexamethasone; Dihydrotestosterone; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Estrogen Antagonists; Humans; Piperidines; Polyunsaturated Alkamides; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Time Factors; Tumor Cells, Cultured | 1989 |
Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line; Estrogen Antagonists; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus | 1984 |
Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens.
Topics: Animals; Cell Line; Chlorocebus aethiops; DNA; Estradiol; Estrogen Antagonists; Gene Expression Regulation; Kidney; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Protein Binding; Protein Conformation; Raloxifene Hydrochloride; Receptors, Estrogen; Recombinant Proteins; Structure-Activity Relationship; Tamoxifen; Transfection | 1995 |
Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones.
Topics: Calcitriol; Creatine Kinase; Endometrium; Estradiol; Estrogen Antagonists; Female; Humans; Osteoblasts; Piperidines; Plasmids; Polyunsaturated Alkamides; Raloxifene Hydrochloride; Recombinant Proteins; Stimulation, Chemical; Tamoxifen; Teriparatide; Tumor Cells, Cultured | 1996 |
FLP recombinase/estrogen receptor fusion proteins require the receptor D domain for responsiveness to antagonists, but not agonists.
Topics: Amino Acid Sequence; Bacterial Outer Membrane Proteins; Diethylstilbestrol; DNA Nucleotidyltransferases; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogens, Non-Steroidal; Fulvestrant; Hexestrol; HSP90 Heat-Shock Proteins; Humans; Ligands; Molecular Sequence Data; Nafoxidine; Piperidines; Raloxifene Hydrochloride; Receptors, Estrogen; Recombinant Fusion Proteins; Tamoxifen; Time Factors; Yeasts | 1997 |
Agonist activity of antiestrogen-receptor complexes to regulate urokinase plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) endogenous gene expression in breast cancer cells.
Topics: Breast Neoplasms; Estrogen Antagonists; Female; Gene Expression Regulation, Neoplastic; Humans; Piperidines; Plasminogen Activator Inhibitor 1; Raloxifene Hydrochloride; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1998 |
Positive and negative discrimination of estrogen receptor agonists and antagonists using site-specific DNA recombinase fusion proteins.
Topics: Diethylstilbestrol; Dimerization; DNA Nucleotidyltransferases; Estradiol; Estrogen Antagonists; Fulvestrant; Hexestrol; Humans; Mutation; Piperidines; Raloxifene Hydrochloride; Receptors, Estrogen; Recombinant Fusion Proteins; Tamoxifen | 1998 |
Comparative analyses of mechanistic differences among antiestrogens.
Topics: Blood Proteins; Breast Neoplasms; Cell Division; Cinnamates; Drug Stability; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Fulvestrant; Gene Expression; Humans; Protein Binding; Protein Conformation; Raloxifene Hydrochloride; Receptors, Estrogen; Stilbenes; Tamoxifen; Transcription, Genetic; Tumor Cells, Cultured | 1999 |
Allosteric silencing of activating function 1 in the 4-hydroxytamoxifen estrogen receptor complex is induced by substituting glycine for aspartate at amino acid 351.
Topics: Allosteric Regulation; Amino Acid Substitution; Aspartic Acid; Binding Sites; Drug Interactions; Estradiol; Estrogen Receptor Modulators; Fulvestrant; Glycine; Humans; Kinetics; Ligands; Mutagenesis, Site-Directed; Protein Conformation; Protein Structure, Tertiary; Raloxifene Hydrochloride; Receptors, Estrogen; RNA, Messenger; Tamoxifen; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2000 |
Distinct mechanisms of action of selective estrogen receptor modulators in breast and osteoblastic cells.
Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Ligands; Mammary Glands, Animal; Osteoblasts; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Response Elements; Tamoxifen | 2000 |
Silencing and reactivation of the selective estrogen receptor modulator-estrogen receptor alpha complex.
Topics: Allosteric Regulation; Breast Neoplasms; Estrogen Receptor alpha; Gene Expression Regulation, Neoplastic; Humans; Protein Conformation; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured | 2001 |
Flexible alignment of small molecules.
Topics: Databases, Factual; Dipeptides; Estradiol; Folic Acid; Ligands; Methotrexate; Models, Molecular; Molecular Conformation; Proteins; Raloxifene Hydrochloride; Succinates; Tamoxifen | 2001 |
Structure-function relationships of the raloxifene-estrogen receptor-alpha complex for regulating transforming growth factor-alpha expression in breast cancer cells.
Topics: Breast Neoplasms; Estrogen Antagonists; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; Nuclear Receptor Coactivator 2; Proteins; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Tamoxifen; Transcription Factors; Transfection; Transforming Growth Factor alpha; Trefoil Factor-1; Tumor Cells, Cultured; Tumor Suppressor Proteins | 2002 |
Differential interactions of estrogens and antiestrogens at the 17 beta-hydroxyl or counterpart hydroxyl with histidine 524 of the human estrogen receptor alpha.
Topics: Alanine; Amino Acid Substitution; Animals; Binding Sites; COS Cells; Diethyl Pyrocarbonate; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Modulators; Estrogens; Histidine; Humans; Hydroxyl Radical; Ligands; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen | 2002 |
Nongenomic activity and subsequent c-fos induction by estrogen receptor ligands are not sufficient to promote deoxyribonucleic acid synthesis in human endometrial adenocarcinoma cells.
Topics: Adenocarcinoma; DNA; Endometrial Neoplasms; Enzyme Activation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression; Humans; Luciferases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-fos; Raloxifene Hydrochloride; Receptors, Estrogen; Recombinant Fusion Proteins; Response Elements; Tamoxifen; Transfection; Tumor Cells, Cultured | 2003 |
Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Breast Neoplasms; DNA Damage; DNA Repair; DNA-Binding Proteins; Enzyme Activation; Epithelial Cells; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Estrogens; Female; Fulvestrant; Guanine; Humans; NAD(P)H Dehydrogenase (Quinone); Oxidative Stress; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Xeroderma Pigmentosum Group A Protein | 2003 |
Mutation of Leu-536 in human estrogen receptor-alpha alters the coupling between ligand binding, transcription activation, and receptor conformation.
Topics: Amino Acid Substitution; Base Sequence; Binding Sites; DNA; Estradiol; Estrogen Receptor alpha; Fulvestrant; HeLa Cells; Humans; In Vitro Techniques; Leucine; Ligands; Models, Molecular; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Protein Conformation; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Transcription Factor AP-1; Transcriptional Activation; Two-Hybrid System Techniques | 2003 |
Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins.
Topics: Acetyltransferases; Genes, Reporter; HeLa Cells; Histone Acetyltransferases; Humans; Nuclear Receptor Coactivator 1; Nuclear Receptor Coactivator 3; Oncogene Proteins; Raloxifene Hydrochloride; Recombinant Fusion Proteins; RNA, Messenger; Selective Estrogen Receptor Modulators; Tamoxifen; Trans-Activators; Transcription Factors | 2004 |
Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens.
Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Fulvestrant; Genes, Reporter; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Pyrrolidines; Raloxifene Hydrochloride; Response Elements; Tamoxifen; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured | 2004 |
Structural basis for the deactivation of the estrogen-related receptor gamma by diethylstilbestrol or 4-hydroxytamoxifen and determinants of selectivity.
Topics: Animals; Binding Sites; Crystallization; Diethylstilbestrol; Dimerization; Estrogen Antagonists; Estrogen Receptor alpha; Estrogens, Non-Steroidal; Mice; Models, Molecular; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Raloxifene Hydrochloride; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Recombinant Proteins; Tamoxifen | 2004 |
Activity of estradiol and selective estrogen receptor modulators in the mouse N20.1 oligodendrocyte/astrocytes cell line.
Topics: Animals; Astrocytes; Blotting, Western; Cell Line; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression Regulation; Ligands; Luciferases; Mice; Neuroglia; Oligodendroglia; Plasmids; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection | 2005 |
Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases.
Topics: Binding Sites; Cloning, Molecular; Cytosol; Endometrium; Escherichia coli; Estrogen Antagonists; Female; Humans; In Vitro Techniques; Liver; Raloxifene Hydrochloride; Sulfotransferases; Tamoxifen | 2006 |
Three-dimensional models of non-steroidal ligands: a comparative molecular field analysis.
Topics: Binding Sites; Binding, Competitive; Breast Neoplasms; Cell Line, Tumor; Computer Simulation; Estrogens; Female; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Ligands; Models, Molecular; Molecular Conformation; Molecular Structure; Quantitative Structure-Activity Relationship; Raloxifene Hydrochloride; Receptors, Estrogen; Reproducibility of Results; Selective Estrogen Receptor Modulators; Tamoxifen | 2006 |
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.
Topics: Acetyltransferases; Alleles; Breast Neoplasms; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Neoplasm; Estradiol; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Receptor Coactivator 3; Oncogene Proteins; Peptides; Polymerase Chain Reaction; Pyrrolidines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators; Sequence Analysis, DNA; Tamoxifen; Thiophenes; Trans-Activators | 2006 |
Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes: synthesis, structure-activity relationships and molecular modeling study for flexible estrogen receptor antagonists.
Topics: Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Proliferation; Cells, Cultured; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Humans; Inhibitory Concentration 50; Ligands; Models, Molecular; Raloxifene Hydrochloride; Receptors, Estrogen; Structure-Activity Relationship; Styrenes; Tamoxifen | 2006 |
Effects of 4-hydroxytamoxifen, raloxifene and ICI 182 780 on survival of uterine cancer cell lines in the presence and absence of exogenous estrogens.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Prohibitins; Protein Binding; Raloxifene Hydrochloride; Receptors, Estrogen; Receptors, G-Protein-Coupled; Tamoxifen; Uterine Neoplasms | 2007 |
Influence of estrogens and antiestrogens on the expression of selected hormone-responsive genes.
Topics: Breast Neoplasms; Carcinoma; Down-Regulation; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Tumor Cells, Cultured; Up-Regulation | 2007 |
Exploration of endocrine-disrupting chemicals on estrogen receptor alpha by the agonist/antagonist differential-docking screening (AADS) method: 4-(1-adamantyl)phenol as a potent endocrine disruptor candidate.
Topics: Adamantane; Diethylstilbestrol; Endocrine Disruptors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Humans; Ligands; Luciferases; Models, Molecular; Phenols; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Tamoxifen | 2009 |
Estrogen and selective estrogen receptor modulators regulate vascular endothelial growth factor and soluble vascular endothelial growth factor receptor 1 in human endometrial stromal cells.
Topics: Adult; Endometrium; Estradiol; Female; Humans; Raloxifene Hydrochloride; RNA, Messenger; Selective Estrogen Receptor Modulators; Stromal Cells; Tamoxifen; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2010 |
Estradiol-induced proliferation of papillary and follicular thyroid cancer cells is mediated by estrogen receptors alpha and beta.
Topics: Carcinoma; Cell Line, Tumor; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Fulvestrant; Humans; Phosphorylation; Raloxifene Hydrochloride; RNA, Small Interfering; Signal Transduction; Tamoxifen; Thyroid Neoplasms | 2010 |
Development and validation of a test for environmental estrogens: Checking xeno-estrogen activity by CXCL12 secretion in BREAST CANCER CELL LINES (CXCL-test).
Topics: Benzhydryl Compounds; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Dose-Response Relationship, Drug; Environmental Monitoring; Environmental Pollutants; Estradiol; Estrogen Receptor Modulators; Estrogens; Ethinyl Estradiol; Female; Genistein; Humans; Phenols; Raloxifene Hydrochloride; Tamoxifen; Time Factors | 2010 |
High content imaging-based assay to classify estrogen receptor-α ligands based on defined mechanistic outcomes.
Topics: Benzhydryl Compounds; Blotting, Western; Cell Line, Tumor; Cluster Analysis; Endocrine Disruptors; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Fulvestrant; Green Fluorescent Proteins; HeLa Cells; Humans; Microscopy, Fluorescence; Phenols; Principal Component Analysis; Promoter Regions, Genetic; Raloxifene Hydrochloride; Reproducibility of Results; Tamoxifen | 2011 |
In-vitro antiproliferative activity of benzopyranone derivatives in comparison with standard chemotherapeutic drugs.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Raloxifene Hydrochloride; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen | 2011 |
Reduction of stimulated sodium iodide symporter expression by estrogen receptor ligands in breast cancer cells.
Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Interactions; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Iodine Radioisotopes; Ligands; Mice; Mice, Inbred BALB C; Raloxifene Hydrochloride; Receptors, Estrogen; RNA, Messenger; Symporters; Tamoxifen; Tretinoin; Xenograft Model Antitumor Assays | 2011 |
In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.
Topics: Animals; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Genes, Reporter; HEK293 Cells; Humans; Luciferases, Firefly; Luciferases, Renilla; Mice; Mice, Nude; Molecular Imaging; Piperidines; Protein Multimerization; Protein Stability; Protein Structure, Tertiary; Pyrazoles; Raloxifene Hydrochloride; Recombinant Fusion Proteins; Selective Estrogen Receptor Modulators; Tamoxifen; Transplantation, Heterologous | 2011 |
Diesel exhaust particulate extracts inhibit transcription of nuclear respiratory factor-1 and cell viability in human umbilical vein endothelial cells.
Topics: Cell Proliferation; Cell Survival; Cells, Cultured; Drug Antagonism; Electron Transport Complex IV; Estradiol; Human Umbilical Vein Endothelial Cells; Humans; Mitochondria; Nuclear Respiratory Factor 1; Particulate Matter; Raloxifene Hydrochloride; Resveratrol; Stilbenes; Tamoxifen; Transcription, Genetic; Vehicle Emissions | 2012 |
Raloxifene inhibits growth of RT4 urothelial carcinoma cells via estrogen receptor-dependent induction of apoptosis and inhibition of proliferation.
Topics: Apoptosis; Carcinoma, Transitional Cell; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Down-Regulation; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Fulvestrant; Humans; Immediate-Early Proteins; MCF-7 Cells; Poly(ADP-ribose) Polymerases; Raloxifene Hydrochloride; S-Phase Kinase-Associated Proteins; Tamoxifen; Tumor Suppressor Proteins; Urinary Bladder Neoplasms | 2013 |
Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling.
Topics: Animals; Biomechanical Phenomena; Calcium; Female; Mice; Muscle Contraction; Myocytes, Cardiac; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Sarcomeres; Tamoxifen | 2013 |
SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites.
Topics: Cell Transformation, Neoplastic; Cells, Cultured; Cytoprotection; Estradiol; Humans; Inactivation, Metabolic; Indoles; Mammary Glands, Human; MCF-7 Cells; Oxidants; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Reactive Oxygen Species; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Up-Regulation | 2014 |
Automatic endpoint detection to support the systematic review process.
Topics: Algorithms; Blood Glucose; Comparative Effectiveness Research; Data Mining; Electronic Data Processing; Evidence-Based Medicine; Female; Humans; Insulin; Language; Linear Models; Linguistics; Machine Learning; Metformin; Natural Language Processing; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Reproducibility of Results; Support Vector Machine; Systematic Reviews as Topic; Tamoxifen; Uterus | 2015 |
Sulfation of afimoxifene, endoxifen, raloxifene, and fulvestrant by the human cytosolic sulfotransferases (SULTs): A systematic analysis.
Topics: Catalysis; Cytosol; Estradiol; Fulvestrant; Hep G2 Cells; Humans; MCF-7 Cells; Raloxifene Hydrochloride; Sulfates; Sulfotransferases; Tamoxifen | 2015 |
Improved specificity of hippocampal memory trace labeling.
Topics: Animals; Bacterial Proteins; Cell Count; Channelrhodopsins; Conditioning, Psychological; Estradiol; Fear; Fulvestrant; Hippocampus; Immunohistochemistry; Luminescent Proteins; Memory; Mice, Transgenic; Microscopy, Confocal; Models, Animal; Neurons; Raloxifene Hydrochloride; Receptors, Estrogen; RNA, Untranslated; Selective Estrogen Receptor Modulators; Tamoxifen | 2016 |
Genome-wide transcriptional regulation of estrogen receptor targets in fallopian tube cells and the role of selective estrogen receptor modulators.
Topics: Animals; Antineoplastic Agents, Hormonal; Carcinoma in Situ; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Estrogen Antagonists; Estrogens; Fallopian Tubes; Female; Gene Expression Regulation, Neoplastic; Genome; Humans; Mice; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Piperidines; Raloxifene Hydrochloride; Receptors, Estrogen; Tamoxifen; Thiophenes; Transcriptome | 2016 |
A transgenic mouse model expressing an ERα folding biosensor reveals the effects of Bisphenol A on estrogen receptor signaling.
Topics: Animals; Benzhydryl Compounds; Biosensing Techniques; Carcinogens; Environmental Exposure; Estrogen Receptor alpha; Estrogens; Fibroblasts; Humans; Luminescent Measurements; Mice, Transgenic; Molecular Imaging; Phenols; Raloxifene Hydrochloride; Recombinant Fusion Proteins; Reproducibility of Results; Selective Estrogen Receptor Modulators; Tamoxifen | 2016 |