Page last updated: 2024-08-16

raloxifene and tamoxifen

raloxifene has been researched along with tamoxifen in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.86)	18.7374
1990's	5 (14.29)	18.2507
2000's	8 (22.86)	29.6817
2010's	16 (45.71)	24.3611
2020's	5 (14.29)	2.80

Authors

Authors	Studies
Blaszczak, LC; Crowell, TA; Goettel, ME; Jones, CD; Mabry, TE; Ruenitz, PC; Srivatsan, V; Suarez, T	1
Black, LJ; Clemens, JA; Falcone, JF; Jevnikar, MG; Jones, CD; Peters, MK; Pike, AJ; Thompson, AR	1
Adrian, MD; Bryant, HU; Cho, S; Cole, HW; Finley, DR; Glasebrook, AL; Godfrey, AG; Grese, TA; Jones, CD; Lugar, CW; Magee, DE; Martin, MJ; Matsumoto, K; Pennington, LD; Phillips, DL; Rowley, ER; Short, LL; Winter, MA	1
Carlsson, B; Enmark, E; Grandien, K; Gustafsson, JA; Häggblad, J; Kuiper, GG; Nilsson, S	1
Adrian, MD; Bryant, HU; Cole, HW; Fuson, TR; Glasebrook, AL; Grese, TA; Magee, DE; Pennington, LD; Phillips, DL; Rowley, ER; Sato, M; Shetler, PK; Short, LL; Sluka, JP; Venugopalan, M; Yang, NN	1
Glasebrook, AL; Misner, JW; Schmid, CR; Stephenson, GA	1
Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Halleux, C; Kallen, J; Keller, H; Renaud, J; Schlaeppi, JM; Stark, W	1
Ikeno, A; Kohayakawa, C; Minato, H; Nakagawa, H; Tsuji, J; Watanabe, N	1
Bischoff, SF; Buhl, T; Floersheim, P; Fournier, B; Geiser, M; Halleux, C; Kallen, J; Keller, H; Ramage, P; Renaud, J	1
Fiechtner, B; Glossmann, H; Hoffmann, RD; Laggner, C; Langer, T; Moebius, FF; Poles, G; Schieferer, C	1
Dansette, PM; Fontana, E; Poli, SM	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Armstrong, MD; Arteaga, CL; Brown, HA; Buck, JR; Cho, HP; Criswell, TL; Lindsley, CW; Scott, SA; Selvy, PE; Thomas, AL	1
Allan, G; Cousineau, M; Du, F; Hahn, D; Jain, N; Jian-Zhong, G; Kanojia, RM; Lai, MT; Li, X; Lundeen, S; Musto, A; Pacia, E; Peng, S; Reuman, M; Ritchie, D; Russell, R; Sui, Z; Xu, J	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Dettmann, S; Gust, R; Müller, CE; Schiedel, A; Szymanowitz, K; Wellner, A	1
Jain, D; Koh, JT	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chang, FR; Chen, GY; Hayashi, K; Hsieh, CJ; Korinek, M; Lai, WC; Nozaki, H; Wang, HC; Wu, CC; Wu, YC; Yang, JC	1
Bid, H; Chakravarti, B; Chattopadhyay, N; Dwivedi, A; Gupta, LP; Konwar, R; Kumar, A; Kumar, P; Nayak, VL; Saxena, R; Siddiquee, MI; Siddiqui, JA; Siddiqui, U; Tripathi, VD; Trivedi, R	1
Hajjo, R; Roth, BL; Setola, V; Tropsha, A	1
Bryant, HU; Chalmers, MJ; Dodge, JA; Griffin, PR; Montrose-Rafizdeh, C; Novick, S; Sato, M; Wang, Y	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Brown, HA; Brown, KA; Cho, CH; Jung, DI; Larock, RC; Lavieri, RR; Lindsley, CW; O'Reilly, MC; Scott, SA; Spencer, CT	1
Balogh, I; Kim, HY; Koczok, K; Korade, Z; Liu, W; Mirnics, K; Porter, NA; Tallman, KA; Xu, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Dandriyal, J; Jaitak, V; Kumar, M; Singla, R	1
Lao, K; Li, X; Luo, G; Tang, Z; Xiang, H; You, Q	1
Cai, X; Li, X; Lin, X; Liu, L; Luo, G; Wu, C; Xiang, H; You, Q	1
Chen, H; Dubrovyskyii, O; Dye, K; Gordon-Blake, J; Gutgesell, LM; He, D; Hollas, M; Huang, F; Lasek, AW; Lee, S; Li, Y; Lu, Y; Rosales, CI; Shen, Z; Thatcher, GRJ; Tonetti, DA; Wang, Y; Xiong, R; Zhao, H; Zhao, J	1
Anantpadma, M; Cheng, H; Cooper, L; Davey, RA; Dye, K; Li, Y; Medegan Fagla, B; Nowar, R; Rong, L; Schafer, A; Shen, Z; Thatcher, GRJ; Xiong, R	1
Aljondi, B; Balakin, KV; Bondar, OV; Bulatov, TM; Gabbasova, RR; Grishaev, DY; Iksanova, AG; Kataeva, ON; Nguyen, TNT; Nikishova, TV; Pavelyev, RS; Pugachev, MV; Shtyrlin, YG; Yamaleeva, ZR	1
Bai, C; Luo, G; Ren, S; Wu, S; Xiang, H; Zhu, M	2
Ahmad, S; Ejaz, I; Ikram, M; Jan, MS; Javed, MA; Rashid, U; Sadiq, A	1

Reviews

3 review(s) available for raloxifene and tamoxifen

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Recent developments of C-4 substituted coumarin derivatives as anticancer agents. European journal of medicinal chemistry, 2016, Aug-25, Volume: 119 Topics: Animals; Antineoplastic Agents; Coumarins; Humans	2016

Other Studies

32 other study(ies) available for raloxifene and tamoxifen

Article	Year
Antiestrogens. 3. Estrogen receptor affinities and antiproliferative effects in MCF-7 cells of phenolic analogues of trioxifene, [3,4-dihydro-2-(4- methoxyphenyl)-1-naphthalenyl][4-[2-(1-pyrrolidinyl)ethoxy]- phenyl]methanone. Journal of medicinal chemistry, 1992, Mar-06, Volume: 35, Issue:5 Topics: Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Calmodulin; Cell Division; Estradiol; Estrogen Antagonists; Humans; Molecular Structure; Phenols; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured	1992
Antiestrogens. 2. Structure-activity studies in a series of 3-aroyl-2-arylbenzo[b]thiophene derivatives leading to [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl] [4-[2-(1-piperidinyl)ethoxy]-phenyl]methanone hydrochloride (LY156758), a remarkably effec Journal of medicinal chemistry, 1984, Volume: 27, Issue:8 Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Estrogen Antagonists; Female; Mammary Neoplasms, Experimental; Piperidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Structure-Activity Relationship; Uterus	1984
Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene. Journal of medicinal chemistry, 1997, Jan-17, Volume: 40, Issue:2 Topics: Adenocarcinoma; Animals; Binding Sites; Bone and Bones; Breast Neoplasms; Cell Division; Cholesterol; Estrogen Antagonists; Female; Humans; Male; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Structure-Activity Relationship; Uterus	1997
Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology, 1997, Volume: 138, Issue:3 Topics: Amino Acid Sequence; Animals; Female; Humans; Isomerism; Ligands; Male; Molecular Sequence Data; Rats; Receptors, Estrogen; RNA, Messenger; Tissue Distribution	1997
Synthesis and pharmacology of conformationally restricted raloxifene analogues: highly potent selective estrogen receptor modulators. Journal of medicinal chemistry, 1998, Apr-09, Volume: 41, Issue:8 Topics: Animals; Bone Density; Cell Division; Cholesterol; Estrogen Antagonists; Female; Gene Expression Regulation; HeLa Cells; Humans; Models, Molecular; Molecular Conformation; Naphthoquinones; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Structure-Activity Relationship; Transforming Growth Factor beta; Tumor Cells, Cultured; Uterus	1998
Synthesis and biological activity of trans-2,3-dihydroraloxifene. Bioorganic & medicinal chemistry letters, 1999, Apr-19, Volume: 9, Issue:8 Topics: Binding, Competitive; Cell Division; Dose-Response Relationship, Drug; Estrogen Antagonists; Models, Molecular; Piperidines; Raloxifene Hydrochloride; Tumor Cells, Cultured	1999
Estrogen receptor modulators: identification and structure-activity relationships of potent ERalpha-selective tetrahydroisoquinoline ligands. Journal of medicinal chemistry, 2003, Jul-03, Volume: 46, Issue:14 Topics: Administration, Oral; Animals; Binding Sites; Biological Availability; Cell Division; Crystallography, X-Ray; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; HeLa Cells; Humans; Isoquinolines; Ligands; Models, Molecular; Radioligand Assay; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Stereoisomerism; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured	2003
4-(4-alkylpiperazin-1-yl)phenyl group: a novel class of basic side chains for selective estrogen receptor modulators. Bioorganic & medicinal chemistry letters, 2003, Dec-15, Volume: 13, Issue:24 Topics: Alkanes; Animals; Cholesterol; Female; Humans; Kinetics; Models, Molecular; Molecular Conformation; Piperazines; Rats; Receptors, Estrogen; Structure-Activity Relationship; Uterus	2003
Selective estrogen receptor modulators with conformationally restricted side chains. Synthesis and structure-activity relationship of ERalpha-selective tetrahydroisoquinoline ligands. Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2 Topics: Animals; Biological Availability; Cell Line, Tumor; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Estrogen Receptor alpha; Female; Humans; Inhibitory Concentration 50; Isoquinolines; Ligands; Models, Molecular; Piperazines; Piperidines; Radioligand Assay; Rats; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Tetrahydroisoquinolines	2005
Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. Journal of medicinal chemistry, 2005, Jul-28, Volume: 48, Issue:15 Topics: Animals; Carrier Proteins; Databases, Factual; Guinea Pigs; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Isomerism; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Radioligand Assay; Receptors, sigma; Saccharomyces cerevisiae; Sigma-1 Receptor; Steroid Isomerases	2005
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nature chemical biology, 2009, Volume: 5, Issue:2 Topics: Breast Neoplasms; Drug Design; Enzyme Inhibitors; Humans; Isoenzymes; Neoplasm Invasiveness; Phospholipase D	2009
Identification and structure-activity relationships of chromene-derived selective estrogen receptor modulators for treatment of postmenopausal symptoms. Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23 Topics: Animals; Benzopyrans; Bone Resorption; Cell Line, Tumor; Cholesterol; Drug Evaluation, Preclinical; Drug Stability; Epithelial Cells; Female; Hot Flashes; Humans; Organ Size; Ovariectomy; Postmenopause; Rats; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Substrate Specificity; Uterus; Vagina	2009
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
2-phenyl-1-[4-(2-piperidine-1-yl-ethoxy)benzyl]-1H-benzimidazoles as ligands for the estrogen receptor: synthesis and pharmacological evaluation. Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14 Topics: Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Estrogen Receptor beta; Female; Gene Expression Regulation, Neoplastic; Humans	2010
A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements. Bioorganic & medicinal chemistry letters, 2010, Sep-01, Volume: 20, Issue:17 Topics: Estrogen Receptor Modulators; Mutation; Receptors, Estrogen; Transcription Factor AP-1	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Using the pER8:GUS reporter system to screen for phytoestrogens from Caesalpinia sappan. Journal of natural products, 2011, Aug-26, Volume: 74, Issue:8 Topics: Arabidopsis; Caesalpinia; Chromones; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Estradiol; Estrogens; Female; Genistein; Hep G2 Cells; Humans; Models, Molecular; Molecular Structure; Phytoestrogens; Plants, Genetically Modified; Selective Estrogen Receptor Modulators; Taiwan; Wood	2011
Design and synthesis of 1,3-biarylsulfanyl derivatives as new anti-breast cancer agents. Bioorganic & medicinal chemistry, 2011, Sep-15, Volume: 19, Issue:18 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; HEK293 Cells; Humans; Models, Molecular; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds	2011
Chemocentric informatics approach to drug discovery: identification and experimental validation of selective estrogen receptor modulators as ligands of 5-hydroxytryptamine-6 receptors and as potential cognition enhancers. Journal of medicinal chemistry, 2012, Jun-28, Volume: 55, Issue:12 Topics: Alzheimer Disease; Cell Line, Tumor; Cloning, Molecular; Cognition; Drug Discovery; Drug Evaluation, Preclinical; Genomics; Humans; Informatics; Ligands; Nootropic Agents; Quantitative Structure-Activity Relationship; Raloxifene Hydrochloride; Receptors, Serotonin; Reproducibility of Results; Selective Estrogen Receptor Modulators; Serotonin Antagonists; User-Computer Interface	2012
Hydrophobic Interactions Improve Selectivity to ERα for Ben-zothiophene SERMs. ACS medicinal chemistry letters, 2012, Mar-08, Volume: 3, Issue:3 Topics:	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes. ACS chemical biology, 2015, Feb-20, Volume: 10, Issue:2 Topics: Animals; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Molecular Structure; Phospholipase D; Pseudomonas aeruginosa; Raloxifene Hydrochloride	2015
The Effect of Small Molecules on Sterol Homeostasis: Measuring 7-Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts. Journal of medicinal chemistry, 2016, Feb-11, Volume: 59, Issue:3 Topics: Animals; Cell Line; Dehydrocholesterols; Dose-Response Relationship, Drug; Fibroblasts; Homeostasis; Humans; Mice; Molecular Conformation; Neurons; Oxidoreductases Acting on CH-CH Group Donors; Small Molecule Libraries; Sterols; Structure-Activity Relationship	2016
Structure-activity relationships of 2, 4-disubstituted pyrimidines as dual ERα/VEGFR-2 ligands with anti-breast cancer activity. European journal of medicinal chemistry, 2018, Apr-25, Volume: 150 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Estrogen Receptor alpha; Female; Humans; Ligands; MCF-7 Cells; Molecular Structure; Neovascularization, Pathologic; Pyrimidines; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2	2018
Synthesis and biological evaluation of 3-aryl-quinolin derivatives as anti-breast cancer agents targeting ERα and VEGFR-2. European journal of medicinal chemistry, 2019, Jan-01, Volume: 161 Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Estrogen Receptor alpha; Female; Humans; Molecular Structure; Protein Kinase Inhibitors; Quinolines; Structure-Activity Relationship; Vascular Endothelial Growth Factor Receptor-2	2019
Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer. Journal of medicinal chemistry, 2019, 12-26, Volume: 62, Issue:24 Topics: Animals; Apoptosis; Aromatase Inhibitors; Breast Neoplasms; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Humans; Mice; Mice, Inbred C57BL; Mice, Nude; Mutation; Proteolysis; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Tissue Distribution; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2019
Screening and Reverse-Engineering of Estrogen Receptor Ligands as Potent Pan-Filovirus Inhibitors. Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19 Topics: Antiviral Agents; Cell Line, Tumor; Drug Evaluation, Preclinical; Filoviridae; Humans; Ligands; Membrane Fusion; Models, Biological; Receptors, Estrogen; Structure-Activity Relationship	2020
Synthesis, antitumor activity and structure-activity studies of novel pyridoxine-based bioisosteric analogs of estradiol. Bioorganic & medicinal chemistry, 2021, 01-15, Volume: 30 Topics: Antineoplastic Agents; Cell Proliferation; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Estradiol; Humans; Membrane Potential, Mitochondrial; Models, Molecular; Molecular Structure; Pyridoxine; Reactive Oxygen Species; Structure-Activity Relationship; Tumor Cells, Cultured	2021
Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer. European journal of medicinal chemistry, 2021, Oct-05, Volume: 221 Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Estrogen Receptor Antagonists; Female; Humans; MCF-7 Cells; Molecular Structure; Receptors, Estrogen; Structure-Activity Relationship; Thiophenes; Tumor Cells, Cultured	2021
Benzothiophene derivatives as selective estrogen receptor covalent antagonists: Design, synthesis and anti-ERα activities. Bioorganic & medicinal chemistry, 2021, 10-01, Volume: 47 Topics: Dose-Response Relationship, Drug; Drug Design; Estrogen Antagonists; Estrogen Receptor alpha; Humans; Molecular Structure; Structure-Activity Relationship; Thiophenes	2021
Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treatment of breast cancer. Bioorganic & medicinal chemistry letters, 2022, 05-15, Volume: 64 Topics: Breast Neoplasms; Cell Proliferation; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; HEK293 Cells; Humans; MCF-7 Cells; Receptors, Estrogen	2022