raclopride and boldine
raclopride has been researched along with boldine* in 1 studies
Other Studies
1 other study(ies) available for raclopride and boldine
| Article | Year |
|---|---|
Halogenated boldine derivatives with enhanced monoamine receptor selectivity.
(S)-(+)-Boldine (1) was brominated, chlorinated, and iodinated using molecular bromine in acetic acid or N-halosuccinimides in trifluoroacetic acid. Initial halogenation occurs at C-3, followed (in the cases of chlorine and bromine) by the less reactive C-8, to afford 3-haloboldines- and 3,8-dihaloboldines (2-5). Using a 2:1 ratio of N-iodosuccinimide to boldine, however, only the 3-iodo derivative 6 was obtained. Radioligand binding studies of these products showed that halogenation of boldine at C-3 favors affinity for D(1)- (vs D(2)-) dopaminergic receptors, attaining a low nanomolar IC(50) value in the case of 3-iodoboldine (6). Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aporphines; Benzazepines; Binding, Competitive; Brain Chemistry; Chlorides; Neostriatum; Raclopride; Radioligand Assay; Rats; Rats, Wistar; Receptors, Biogenic Amine; Receptors, Dopamine D1; Receptors, Dopamine D2 | 2000 |