r115777 and lonafarnib
r115777 has been researched along with lonafarnib in 3 studies
Compound Research Comparison
| Studies (r115777) | Trials (r115777) | Recent Studies (post-2010) (r115777) | Studies (lonafarnib) | Trials (lonafarnib) | Recent Studies (post-2010) (lonafarnib) |
|---|---|---|---|---|---|
| 8 | 0 | 4 | 224 | 34 | 90 |
| 8 | 0 | 4 | 6 | 0 | 3 |
Protein Interaction Comparison
| Protein | Taxonomy | r115777 (IC50) | lonafarnib (IC50) |
|---|---|---|---|
| Chain A, Protein farnesyltransferase alpha subunit | Rattus norvegicus (Norway rat) | 0.0019 | |
| Chain B, Protein farnesyltransferase beta subunit | Rattus norvegicus (Norway rat) | 0.0019 | |
| GTPase HRas | Homo sapiens (human) | 0.07 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 2.7 | |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Bos taurus (cattle) | 0.0083 | |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Homo sapiens (human) | 0.1498 | |
| Protein farnesyltransferase subunit beta | Bos taurus (cattle) | 0.0083 | |
| Protein farnesyltransferase subunit beta | Homo sapiens (human) | 0.1498 | |
| Protein farnesyltransferase subunit beta | Rattus norvegicus (Norway rat) | 0.0019 | |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Rattus norvegicus (Norway rat) | 0.0019 | |
| Geranylgeranyl transferase type-1 subunit beta | Bos taurus (cattle) | 0.0083 |
Research
Studies (3)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Claiborne, A; Cohen, J; Frost, D; Gu, WZ; Hutchins, C; Li, Q; Lin, NH; Rosenberg, SH; Sham, HL; Stoll, VS; Wang, W; Woods, KW | 1 |
| Bauer, KD; Bendale, P; Buckner, FS; Chakrabarti, D; Floyd, D; Gelb, MH; Hamilton, A; Hornéy, CP; Lombardo, LJ; Nallan, L; Pendyala, PR; Rivas, K; Sebti, S; Van Voorhis, WC; Weber, PC; Williams, DK; Windsor, WT; Yokoyama, K | 1 |
| Cohen, J; Frost, D; Galicia, T; Gu, WZ; Hutchins, C; Li, Q; Li, T; Rosenberg, SH; Sham, HL; Stoll, VS; Woods, KW | 1 |
Other Studies
3 other study(ies) available for r115777 and lonafarnib
| Article | Year |
|---|---|
Design, synthesis, and activity of achiral analogs of 2-quinolones and indoles as non-thiol farnesyltransferase inhibitors.
Topics: Alkyl and Aryl Transferases; Animals; Cattle; Drug Design; Enzyme Inhibitors; Farnesyltranstransferase; Hydroxyquinolines; Indoles; Mice; NIH 3T3 Cells; Quinolones; Stereoisomerism | 2005 |
Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Topics: Alkyl and Aryl Transferases; Animals; Antimalarials; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Farnesyltranstransferase; Female; Humans; Malaria; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Plasmodium berghei; Plasmodium falciparum; Protein Prenylation; Quinolones; Rats; Structure-Activity Relationship | 2005 |
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity.
Topics: Alkyl and Aryl Transferases; Animals; Benzimidazoles; Enzyme Inhibitors; Farnesyltranstransferase; Indoles; Mice; NIH 3T3 Cells; Quinolones | 2005 |