r-59274 has been researched along with carboprostacyclin* in 2 studies
2 other study(ies) available for r-59274 and carboprostacyclin
Article | Year |
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Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin in the arteriole of the hamster cheek pouch.
Antithrombotic effects of sodium salt of 17(R)-methyl-20-isopropylidenecarbacyclin (CS-570), a chemically stable prostaglandin I2 (PGI2, epoprostenol, prostacyclin) derivative, were investigated in the arteriole of the hamster cheek pouch. A microthrombus was produced by a slight mechanical injury followed by iontophoretic application of adenosine diphosphate (ADP) to an arteriole of 70 to 100 micron in diameter. The platelet thrombus size was determined with a video image processor. With this technique, a reproducible and quantitatively measurable periodical thrombus was obtained. CS-570 inhibited the thrombus formation dose-dependently. The potency of CS-570 was about 1/8 that of PGI2 and 6 times that of carbacyclin when infused i.v. CS-570 also decomposed an established thrombus. Alprostadil (PGE1), dipyridamole and ticlopidine failed to show inhibitory effects. The antithrombotic effect of CS-570 was definitely demonstrated. Topics: Adenosine Diphosphate; Animals; Arteries; Cheek; Cricetinae; Dipyridamole; Epoprostenol; Fibrinolytic Agents; Male; Mesocricetus; Regional Blood Flow; Thiophenes; Ticlopidine; Time Factors | 1986 |
[Effects of prostacyclin and its derivatives on the airway, pulmonary vascular system, and chemical mediator release].
Topics: Animals; Aorta, Thoracic; Depression, Chemical; Epoprostenol; Guinea Pigs; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prostaglandins, Synthetic; Pulmonary Artery; Rabbits; SRS-A; Trachea | 1983 |