Compounds > r 56865

Page last updated: 2024-09-02

r 56865 and tetrodotoxin

r 56865 has been researched along with tetrodotoxin in 10 studies

Compound Research Comparison

Studies (r 56865)	Trials (r 56865)	Recent Studies (post-2010) (r 56865)	Studies (tetrodotoxin)	Trials (tetrodotoxin)	Recent Studies (post-2010) (tetrodotoxin)
72	1	0	12,992	11	1,477

Protein Interaction Comparison

Protein	Taxonomy	r 56865 (IC50)	tetrodotoxin (IC50)
Sodium channel protein type 9 subunit alpha	Homo sapiens (human)		0.0186

Research

Studies (10)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	9 (90.00)	18.2507
2000's	1 (10.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Leidig, A; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wirth, A	1
Gleitz, J; Peters, T; Tegtmeier, F; Urenjak, J; Wermelskirchen, D; Wilffert, B	1
Borgers, M; Ver Donck, L	1
Bielen, FV; Ver Donck, L; Verdonck, F	1
Coraboeuf, E; John, GW; Le Grand, B; Talmant, JM; Vie, B	1
De Clerck, F; Lu, HR	1
Haigney, MC; Lakatta, EG; Silverman, HS; Stern, MD	1
Chizhmakov, IV; Kiskin, NI; Krishtal, OA; Tegtmeier, F	1
De Clerck, F; Lu, HR; Remeysen, P	1
Le Grand, B; Létienne, R; Vié, B	1

Other Studies

10 other study(ies) available for r 56865 and tetrodotoxin

Article	Year
Veratridine activates a silent sodium channel in rat isolated aorta. European journal of pharmacology, 1992, Aug-25, Volume: 219, Issue:2 Topics: Amiloride; Animals; Aorta; Benzothiazoles; Calcium; Guanidine; Guanidines; In Vitro Techniques; Piperidines; Pyrroles; Rats; Sodium Channels; Tetrodotoxin; Thiazoles; Vasodilator Agents; Veratridine	1992
Flunarizine and R 56865 suppress veratridine-induced increase in oxygen consumption and uptake of 45Ca2+ in rat cortical synaptosomes. Neuropharmacology, 1992, Volume: 31, Issue:3 Topics: Animals; Benzothiazoles; Calcium; Calcium Radioisotopes; Cerebral Cortex; Flunarizine; In Vitro Techniques; Oxygen Consumption; Piperidines; Polarography; Rats; Synaptosomes; Tetrodotoxin; Thiazoles; Veratridine	1992
Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology. The American journal of physiology, 1991, Volume: 261, Issue:6 Pt 2 Topics: Animals; Benzothiazoles; Calcium; Cardiomyopathies; Heart; Lysophosphatidylcholines; Myocardial Contraction; Ouabain; Oxygen; Piperidines; Rabbits; Rats; Singlet Oxygen; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine	1991
Preferential block of the veratridine-induced, non-inactivating Na+ current by R56865 in single cardiac Purkinje cells. European journal of pharmacology, 1991, Oct-22, Volume: 203, Issue:3 Topics: Animals; Benzothiazoles; Heart; In Vitro Techniques; Membrane Potentials; Myocardium; Piperidines; Purkinje Cells; Rabbits; Sodium Channels; Tetrodotoxin; Thiazoles; Veratridine	1991
Alleviation of contractile dysfunction in ischemic hearts by slowly inactivating Na+ current blockers. The American journal of physiology, 1995, Volume: 269, Issue:2 Pt 2 Topics: Action Potentials; Animals; Benzothiazoles; Biomechanical Phenomena; Electric Conductivity; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Papillary Muscles; Piperidines; Reference Values; Sodium; Tetrodotoxin; Thiazoles	1995
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo. Journal of cardiovascular pharmacology, 1993, Volume: 22, Issue:1 Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil	1993
Sodium channel blockade reduces hypoxic sodium loading and sodium-dependent calcium loading. Circulation, 1994, Volume: 90, Issue:1 Topics: Amiloride; Animals; Benzofurans; Benzothiazoles; Calcium; Calcium Channel Blockers; Cell Separation; Ethers, Cyclic; Fluorescent Dyes; Hypoxia; Lidocaine; Myocardial Contraction; Myocardium; Piperidines; Rats; Sodium; Sodium Channel Blockers; Sodium-Hydrogen Exchangers; Tetrodotoxin; Thiazoles	1994
R56865 and flunarizine as Na(+)-channel blockers in isolated Purkinje neurons of rat cerebellum. Neuroscience, 1993, Volume: 54, Issue:3 Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cerebellum; Electric Stimulation; Electrophysiology; Flunarizine; In Vitro Techniques; Piperidines; Purkinje Cells; Rats; Rats, Wistar; Sodium Channels; Tetrodotoxin; Thiazoles	1993
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs. European journal of pharmacology, 1993, Apr-22, Volume: 235, Issue:1 Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil	1993
Pharmacological characterisation of sodium channels in sinoatrial node pacemaking in the rat heart. European journal of pharmacology, 2006, Jan-20, Volume: 530, Issue:3 Topics: Animals; Benzothiazoles; Bradycardia; Heart Atria; Heart Rate; Lidocaine; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sinoatrial Node; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Thiadiazoles; Thiazoles	2006