qx-222 has been researched along with qx-314 in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 6 (42.86) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ransom, BR; Stys, PK; Waxman, SG | 1 |
| Oortgiesen, M; van Kleef, RG; Vijverberg, HP | 1 |
| Brodwick, MS; Dickey, WD; Horn, R | 1 |
| Gintant, GA; Hoffman, BF; Naylor, RE | 1 |
| Gintant, GA; Hoffman, BF | 1 |
| Tinker, A; Williams, AJ | 1 |
| Andreasen, M; Hablitz, JJ | 1 |
| Dudley, SC; Fozzard, HA; Sunami, A | 1 |
| Karlin, A; Pascual, JM | 1 |
| Fozzard, HA; Glaaser, IW; Sunami, A | 2 |
| Geddis, LM; Kutchai, H | 1 |
| Fortune, ES; Rose, GJ | 1 |
| Kohane, DS; Sagie, I | 1 |
14 other study(ies) available for qx-222 and qx-314
| Article | Year |
|---|---|
Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.
Topics: Action Potentials; Anesthetics, Local; Animals; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Neurons; Optic Nerve; Procaine; Rats; Sodium Channels | 1992 |
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.
Topics: Anesthetics, Local; Animals; Cell Line; Electric Conductivity; Insecticides; Kinetics; Lidocaine; Membrane Potentials; Mice; Neuroblastoma; Nitriles; Pyrethrins; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured | 1990 |
Asymmetry of the acetylcholine channel revealed by quaternary anesthetics.
Topics: Acetylcholine; Animals; Ion Channels; Lidocaine; Membrane Potentials; Membrane Proteins; Motor Endplate; Neuromuscular Junction; Rats; Receptors, Cholinergic; Sodium; Structure-Activity Relationship | 1980 |
The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Benzocaine; Dogs; Heart Conduction System; Ion Channels; Lidocaine; Membrane Potentials; Molecular Conformation; Purkinje Fibers; Sodium; Tocainide | 1983 |
Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine.
Topics: Action Potentials; Animals; Dogs; Ion Channels; Lidocaine; Myocardium; Purkinje Fibers; Sodium | 1984 |
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.
Topics: Anesthetics, Local; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electric Conductivity; Ion Channel Gating; Kinetics; Lidocaine; Lipid Bilayers; Membrane Potentials; Procaine; Sarcoplasmic Reticulum; Sheep | 1993 |
Local anesthetics block transient outward potassium currents in rat neocortical neurons.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Cerebral Cortex; Lidocaine; Membrane Potentials; Microinjections; Neurons; Potassium Channels; Rats; Sodium Channels | 1993 |
Sodium channel selectivity filter regulates antiarrhythmic drug binding.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Binding Sites; Female; In Vitro Techniques; Lidocaine; Models, Biological; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Rats; Sodium Channel Blockers; Sodium Channels; Xenopus | 1997 |
Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Binding Sites; Cysteine; Cytoplasm; Electrophysiology; Indicators and Reagents; Ion Channel Gating; Kinetics; Lidocaine; Mesylates; Mice; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Oocytes; Protein Conformation; Receptors, Cholinergic; Xenopus | 1998 |
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
Topics: Anesthetics, Local; Animals; Binding Sites; Lidocaine; Muscle, Skeletal; Mutagenesis; Myocardium; NAV1.8 Voltage-Gated Sodium Channel; Protein Isoforms; Rats; Sodium Channels; Tetrodotoxin; Xenopus | 2000 |
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
Topics: Amino Acid Substitution; Anesthetics, Local; Animals; Calcium Channel Blockers; Cells, Cultured; Conotoxins; Ethyl Methanesulfonate; Ion Channel Gating; Lidocaine; Mesylates; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Rats; Saxitoxin; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tetrodotoxin; Transfection; Xenopus laevis | 2001 |
Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Dogs; Kidney Medulla; Lidocaine; Mepivacaine; Procaine; Protein Binding; Ropivacaine; Sodium Channels; Sodium-Potassium-Exchanging ATPase | 2001 |
Voltage-gated Na+ channels enhance the temporal filtering properties of electrosensory neurons in the torus.
Topics: Action Potentials; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Gymnotiformes; Lidocaine; Neurons, Afferent; Sodium Channel Blockers; Sodium Channels | 2003 |
Prolonged sensory-selective nerve blockade.
Topics: Anesthetics, Local; Animals; Drug Interactions; Injections, Subcutaneous; Lidocaine; Male; Nerve Block; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; Surface-Active Agents | 2010 |