Page last updated: 2024-08-16

qx-222 and qx-314

qx-222 has been researched along with qx-314 in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19903 (21.43)18.7374
1990's6 (42.86)18.2507
2000's4 (28.57)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ransom, BR; Stys, PK; Waxman, SG1
Oortgiesen, M; van Kleef, RG; Vijverberg, HP1
Brodwick, MS; Dickey, WD; Horn, R1
Gintant, GA; Hoffman, BF; Naylor, RE1
Gintant, GA; Hoffman, BF1
Tinker, A; Williams, AJ1
Andreasen, M; Hablitz, JJ1
Dudley, SC; Fozzard, HA; Sunami, A1
Karlin, A; Pascual, JM1
Fozzard, HA; Glaaser, IW; Sunami, A2
Geddis, LM; Kutchai, H1
Fortune, ES; Rose, GJ1
Kohane, DS; Sagie, I1

Other Studies

14 other study(ies) available for qx-222 and qx-314

ArticleYear
Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.
    Journal of neurophysiology, 1992, Volume: 67, Issue:1

    Topics: Action Potentials; Anesthetics, Local; Animals; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Neurons; Optic Nerve; Procaine; Rats; Sodium Channels

1992
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.
    Brain research, 1990, Jun-04, Volume: 518, Issue:1-2

    Topics: Anesthetics, Local; Animals; Cell Line; Electric Conductivity; Insecticides; Kinetics; Lidocaine; Membrane Potentials; Mice; Neuroblastoma; Nitriles; Pyrethrins; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured

1990
Asymmetry of the acetylcholine channel revealed by quaternary anesthetics.
    Science (New York, N.Y.), 1980, Oct-10, Volume: 210, Issue:4466

    Topics: Acetylcholine; Animals; Ion Channels; Lidocaine; Membrane Potentials; Membrane Proteins; Motor Endplate; Neuromuscular Junction; Rats; Receptors, Cholinergic; Sodium; Structure-Activity Relationship

1980
The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.
    Circulation research, 1983, Volume: 52, Issue:6

    Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Benzocaine; Dogs; Heart Conduction System; Ion Channels; Lidocaine; Membrane Potentials; Molecular Conformation; Purkinje Fibers; Sodium; Tocainide

1983
Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine.
    Pflugers Archiv : European journal of physiology, 1984, Volume: 400, Issue:2

    Topics: Action Potentials; Animals; Dogs; Ion Channels; Lidocaine; Myocardium; Purkinje Fibers; Sodium

1984
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.
    Biophysical journal, 1993, Volume: 65, Issue:2

    Topics: Anesthetics, Local; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electric Conductivity; Ion Channel Gating; Kinetics; Lidocaine; Lipid Bilayers; Membrane Potentials; Procaine; Sarcoplasmic Reticulum; Sheep

1993
Local anesthetics block transient outward potassium currents in rat neocortical neurons.
    Journal of neurophysiology, 1993, Volume: 69, Issue:6

    Topics: Anesthetics, Local; Animals; Cells, Cultured; Cerebral Cortex; Lidocaine; Membrane Potentials; Microinjections; Neurons; Potassium Channels; Rats; Sodium Channels

1993
Sodium channel selectivity filter regulates antiarrhythmic drug binding.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Dec-09, Volume: 94, Issue:25

    Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Binding Sites; Female; In Vitro Techniques; Lidocaine; Models, Biological; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Rats; Sodium Channel Blockers; Sodium Channels; Xenopus

1997
Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.
    The Journal of general physiology, 1998, Volume: 112, Issue:5

    Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Binding Sites; Cysteine; Cytoplasm; Electrophysiology; Indicators and Reagents; Ion Channel Gating; Kinetics; Lidocaine; Mesylates; Mice; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Oocytes; Protein Conformation; Receptors, Cholinergic; Xenopus

1998
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-29, Volume: 97, Issue:5

    Topics: Anesthetics, Local; Animals; Binding Sites; Lidocaine; Muscle, Skeletal; Mutagenesis; Myocardium; NAV1.8 Voltage-Gated Sodium Channel; Protein Isoforms; Rats; Sodium Channels; Tetrodotoxin; Xenopus

2000
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
    Molecular pharmacology, 2001, Volume: 59, Issue:4

    Topics: Amino Acid Substitution; Anesthetics, Local; Animals; Calcium Channel Blockers; Cells, Cultured; Conotoxins; Ethyl Methanesulfonate; Ion Channel Gating; Lidocaine; Mesylates; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Rats; Saxitoxin; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tetrodotoxin; Transfection; Xenopus laevis

2001
Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
    Pharmacological research, 2001, Volume: 43, Issue:4

    Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Dogs; Kidney Medulla; Lidocaine; Mepivacaine; Procaine; Protein Binding; Ropivacaine; Sodium Channels; Sodium-Potassium-Exchanging ATPase

2001
Voltage-gated Na+ channels enhance the temporal filtering properties of electrosensory neurons in the torus.
    Journal of neurophysiology, 2003, Volume: 90, Issue:2

    Topics: Action Potentials; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Gymnotiformes; Lidocaine; Neurons, Afferent; Sodium Channel Blockers; Sodium Channels

2003
Prolonged sensory-selective nerve blockade.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Feb-23, Volume: 107, Issue:8

    Topics: Anesthetics, Local; Animals; Drug Interactions; Injections, Subcutaneous; Lidocaine; Male; Nerve Block; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; Surface-Active Agents

2010