qx-222 has been researched along with lidocaine in 49 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 14 (28.57) | 18.7374 |
1990's | 21 (42.86) | 18.2507 |
2000's | 9 (18.37) | 29.6817 |
2010's | 5 (10.20) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Neher, E; Steinbach, JH | 1 |
Beam, KG | 1 |
Ransom, BR; Stys, PK; Waxman, SG | 1 |
Charnet, P; Cohen, BN; Davidson, N; Labarca, C; Lester, HA; Pilar, G | 1 |
Audinat, E; Gähwiler, BH; Knöpfel, T | 1 |
Charnet, P; Labarca, C; Lester, HA | 1 |
Cohen, BN; Davidson, N; Labarca, C; Lester, HA | 1 |
Charnet, P; Czyzyk, L; Davidson, N; Gouin, A; Labarca, C; Leonard, RJ; Lester, HA; Vogelaar, NJ | 3 |
Auerbach, A | 1 |
Oortgiesen, M; van Kleef, RG; Vijverberg, HP | 1 |
Hsiung, GR; Puil, E | 1 |
MacVicar, BA; Pittman, QJ; Williams, PJ | 1 |
Agnew, WS; Emerick, MC; Rosenberg, RL; Tomiko, SA | 1 |
Starmer, CF; Tanguy, J; Yeh, JZ | 1 |
Grant, AO; Packer, DL; Starmer, CF | 1 |
Lingle, C | 1 |
Carlen, PL; Puil, E | 1 |
Brodwick, MS; Dickey, WD; Horn, R | 1 |
Engberg, I; Flatman, JA; Lambert, JD | 2 |
Gintant, GA; Hoffman, BF; Naylor, RE | 1 |
Neher, E | 1 |
Gintant, GA; Hoffman, BF | 1 |
Ruff, RL | 1 |
Adams, DJ; Cuevas, J | 1 |
Dilger, JP; Vidal, AM | 1 |
Hanck, DA; Makielski, JC; Sheets, MF | 1 |
Tinker, A; Williams, AJ | 1 |
Andreasen, M; Hablitz, JJ | 1 |
Makielski, JC; Undrovinas, AI | 1 |
Barrantes, FJ; Bouzat, C | 1 |
Dudley, SC; Fozzard, HA; Sunami, A | 1 |
Karlin, A; Pascual, JM | 1 |
Fozzard, HA; Glaaser, IW; Sunami, A | 2 |
Geddis, LM; Kutchai, H | 1 |
Barrantes, GE; Ortells, MO | 1 |
Fortune, ES; Rose, GJ | 1 |
Lardin, HA; Lee, PJ | 1 |
Hanck, DA; Sheets, MF | 1 |
Akabas, MH; Bali, M; Jansen, M | 1 |
Arevalo, E; Chiara, DC; Cohen, JB; Forman, SA; Hong, FH; Husain, SS; Miller, KW | 1 |
Kohane, DS; Sagie, I | 1 |
Benziane, B; Chibalin, AV; Heiny, JA; Kravtsova, VV; Krivoi, II; Mandel, F; Pedersen, SE; Prokofiev, AV; Radzyukevich, TL | 1 |
Dasgupta, D; Sikdar, SK | 1 |
Chen, C; Gui, JB; Hu, SP; Liu, Y; Wang, WX; Wu, HF; Yu, L; Zhao, JJ | 1 |
Alvarez, FJ; Liu, C; Reinert, NJ; Tang, P; Tillman, TS; Wang, D; Xiao, K; Xu, Y; Zhang, P | 1 |
2 review(s) available for qx-222 and lidocaine
Article | Year |
---|---|
Mutations affecting local anesthetic block of the nicotinic acetylcholine receptor ion channel.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Humans; Ion Channels; Lidocaine; Molecular Sequence Data; Mutation; Receptors, Nicotinic | 1991 |
Reverse pharmacology of the nicotinic acetylcholine receptor. Mapping the local anesthetic binding site.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Binding Sites; Kinetics; Lidocaine; Mice; Models, Molecular; Molecular Sequence Data; Protein Conformation; Receptors, Nicotinic; Sequence Homology, Nucleic Acid | 1991 |
47 other study(ies) available for qx-222 and lidocaine
Article | Year |
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Local anaesthetics transiently block currents through single acetylcholine-receptor channels.
Topics: Animals; Anura; In Vitro Techniques; Kinetics; Lidocaine; Membrane Potentials; Muscle Denervation; Neuromuscular Junction; Rana pipiens; Receptors, Cholinergic | 1978 |
A voltage-clamp study of the effect of two lidocaine derivatives on the time course of end-plate currents.
Topics: Animals; Electric Conductivity; Ethylamines; Kinetics; Lidocaine; Membrane Potentials; Methylamines; Models, Biological; Motor Endplate; Neuromuscular Junction; Rana pipiens; Time Factors | 1976 |
Tertiary and quaternary local anesthetics protect CNS white matter from anoxic injury at concentrations that do not block excitability.
Topics: Action Potentials; Anesthetics, Local; Animals; Hypoxia, Brain; In Vitro Techniques; Lidocaine; Neurons; Optic Nerve; Procaine; Rats; Sodium Channels | 1992 |
Pharmacological and kinetic properties of alpha 4 beta 2 neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.
Topics: Acetylcholine; Animals; Cells, Cultured; Electrophysiology; Hexamethonium; Hexamethonium Compounds; Kinetics; Lidocaine; Membrane Potentials; Muscles; Neurons; Oocytes; Receptors, Nicotinic; Xenopus | 1992 |
Excitatory synaptic potentials in neurons of the deep nuclei in olivo-cerebellar slice cultures.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Bicuculline; Cell Communication; Cells, Cultured; Cerebellar Nuclei; Electric Stimulation; Evoked Potentials; In Vitro Techniques; Lidocaine; Magnesium; Neurons; Olivary Nucleus; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Neurotransmitter; Synapses | 1992 |
Structure of the gamma-less nicotinic acetylcholine receptor: learning from omission.
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; DNA; Electrophysiology; Lidocaine; Mice; Molecular Sequence Data; Molecular Structure; Mutation; Receptors, Nicotinic; RNA; Xenopus | 1992 |
Mutations in M2 alter the selectivity of the mouse nicotinic acetylcholine receptor for organic and alkali metal cations.
Topics: Amino Acid Sequence; Ammonia; Animals; Cations; Cell Membrane Permeability; Cesium; Female; Glycine; Guanidine; Guanidines; Lidocaine; Mice; Molecular Sequence Data; Mutation; Oocytes; Receptors, Nicotinic; Sodium; Temperature; Torpedo; Xenopus | 1992 |
An open-channel blocker interacts with adjacent turns of alpha-helices in the nicotinic acetylcholine receptor.
Topics: Amino Acid Sequence; Amino Acids; Animals; Electrophysiology; Ion Channels; Kinetics; Lidocaine; Mice; Molecular Sequence Data; Mutation; Oocytes; Protein Conformation; Receptors, Nicotinic | 1990 |
Single-channel dose-response studies in single, cell-attached patches.
Topics: Acetylcholine; Animals; Cells, Cultured; Embryo, Nonmammalian; Ion Channels; Kinetics; Lidocaine; Mathematics; Models, Biological; Muscles; Receptors, Cholinergic; Sodium; Spectrometry, Fluorescence; Xenopus | 1991 |
Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.
Topics: Anesthetics, Local; Animals; Cell Line; Electric Conductivity; Insecticides; Kinetics; Lidocaine; Membrane Potentials; Mice; Neuroblastoma; Nitriles; Pyrethrins; Sodium Channels; Tetrodotoxin; Tumor Cells, Cultured | 1990 |
Ionic dependencies of tetrodotoxin-resistant action potentials in trigeminal root ganglion neurons.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium; Cisplatin; Doxorubicin; Electrodes; Guinea Pigs; In Vitro Techniques; Lidocaine; Neurons; Potassium Channels; Sodium; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Trigeminal Ganglion | 1990 |
Electrophysiological properties of neuroendocrine cells of the intact rat pars intermedia: multiple calcium currents.
Topics: Action Potentials; Animals; Calcium; Electrophysiology; Lidocaine; Male; Neurosecretory Systems; Pituitary Gland; Rats; Rats, Inbred Strains; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1990 |
Fluorescence assay for neurotoxin-modulated ion transport by the reconstituted voltage-activated sodium channel isolated from eel electric organ.
Topics: Animals; Batrachotoxins; Carrier Proteins; Electric Organ; Electrophorus; Ion Channels; Lidocaine; Liposomes; Mathematics; Models, Neurological; Naphthalenes; Neurotoxins; Sodium; Sodium Channels; Spectrometry, Fluorescence; Tellurium; Tetrodotoxin; Veratridine | 1986 |
A quantitative description of QX222 blockade of sodium channels in squid axons.
Topics: Animals; Axons; Decapodiformes; Ion Channels; Kinetics; Lidocaine; Mathematics; Models, Neurological; Sodium | 1986 |
Ligand binding to transiently accessible sites: mechanisms for varying apparent binding rates.
Topics: Animals; Axons; Binding Sites; Decapodiformes; Ion Channels; Kinetics; Lidocaine; Ligands; Membrane Potentials; Sodium | 1987 |
Different types of blockade of crustacean acetylcholine-induced currents.
Topics: Animals; Atropine; Carbachol; Curare; Decamethonium Compounds; Dose-Response Relationship, Drug; Ganglionic Blockers; Ion Channels; Lidocaine; Membrane Potentials; Muscles; Nephropidae; Parasympatholytics; Procaine; Trimethaphan | 1983 |
Attenuation of glutamate-action, excitatory postsynaptic potentials, and spikes by intracellular QX 222 in hippocampal neurons.
Topics: Action Potentials; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Guinea Pigs; Hippocampus; In Vitro Techniques; Ion Channels; Lidocaine; Membrane Potentials; Neurons; Synapses | 1984 |
Asymmetry of the acetylcholine channel revealed by quaternary anesthetics.
Topics: Acetylcholine; Animals; Ion Channels; Lidocaine; Membrane Potentials; Membrane Proteins; Motor Endplate; Neuromuscular Junction; Rats; Receptors, Cholinergic; Sodium; Structure-Activity Relationship | 1980 |
Reversibility of Ia EPSP investigated with intracellularly iontophoresed QX-222.
Topics: Animals; Cats; Evoked Potentials; Female; Lidocaine; Male; Motor Neurons; Muscle Spindles; Spinal Cord; Synapses; Synaptic Transmission | 1982 |
The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Benzocaine; Dogs; Heart Conduction System; Ion Channels; Lidocaine; Membrane Potentials; Molecular Conformation; Purkinje Fibers; Sodium; Tocainide | 1983 |
The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics.
Topics: Acetylcholine; Anesthetics, Local; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Ion Channels; Lidocaine; Membrane Potentials; Models, Biological; Muscles; Rats; Time Factors | 1983 |
Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine.
Topics: Action Potentials; Animals; Dogs; Ion Channels; Lidocaine; Myocardium; Purkinje Fibers; Sodium | 1984 |
The response of cat spinal motoneurones to the intracellular application of agents with local anaesthetic action.
Topics: Action Potentials; Anesthetics, Local; Animals; Cats; Choline; Electric Stimulation; Evoked Potentials; Female; Lidocaine; Male; Microelectrodes; Motor Neurons; Neural Conduction | 1984 |
The kinetics of local anesthetic blockade of end-plate channels.
Topics: Anesthetics, Local; Animals; Filtration; Kinetics; Lidocaine; Mathematics; Neuromuscular Junction; Rana pipiens | 1982 |
Local anaesthetic blockade of neuronal nicotinic ACh receptor-channels in rat parasympathetic ganglion cells.
Topics: Acetylcholine; Animals; Cells, Cultured; Ganglia, Parasympathetic; Ion Channel Gating; Ion Channels; Kinetics; Lidocaine; Membrane Potentials; Neurons; Nicotinic Antagonists; Procaine; Rats; Receptors, Muscarinic; Receptors, Nicotinic | 1994 |
Cooperative interactions between general anesthetics and QX-222 within the pore of the acetylcholine receptor ion channel.
Topics: Anesthetics; Cell Line; Drug Interactions; Ion Channels; Lidocaine; Membrane Potentials; Receptors, Cholinergic | 1994 |
Kinetic effects of quaternary lidocaine block of cardiac sodium channels: a gating current study.
Topics: Animals; Benzocaine; Dogs; Electrophysiology; In Vitro Techniques; Ion Channel Gating; Kinetics; Lidocaine; Myocardium; Purkinje Fibers; Saxitoxin; Sodium Channels | 1994 |
Charged local anesthetics block ionic conduction in the sheep cardiac sarcoplasmic reticulum calcium release channel.
Topics: Anesthetics, Local; Animals; Calcium Channels; Dose-Response Relationship, Drug; Electric Conductivity; Ion Channel Gating; Kinetics; Lidocaine; Lipid Bilayers; Membrane Potentials; Procaine; Sarcoplasmic Reticulum; Sheep | 1993 |
Local anesthetics block transient outward potassium currents in rat neocortical neurons.
Topics: Anesthetics, Local; Animals; Cells, Cultured; Cerebral Cortex; Lidocaine; Membrane Potentials; Microinjections; Neurons; Potassium Channels; Rats; Sodium Channels | 1993 |
Blockade of lysophosphatidylcholine-modified cardiac Na channels by a lidocaine derivative QX-222.
Topics: Animals; Electric Conductivity; Lidocaine; Lysophosphatidylcholines; Myocardium; Patch-Clamp Techniques; Rabbits; Rats; Sodium Channel Blockers; Sodium Channels | 1996 |
Modulation of muscle nicotinic acetylcholine receptors by the glucocorticoid hydrocortisone. Possible allosteric mechanism of channel blockade.
Topics: Adult; Allosteric Regulation; Cell Line; Humans; Hydrocortisone; In Vitro Techniques; Kidney; Kinetics; Lidocaine; Muscles; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Receptors, Nicotinic | 1996 |
Sodium channel selectivity filter regulates antiarrhythmic drug binding.
Topics: Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Binding Sites; Female; In Vitro Techniques; Lidocaine; Models, Biological; Mutagenesis, Site-Directed; Oocytes; Point Mutation; Rats; Sodium Channel Blockers; Sodium Channels; Xenopus | 1997 |
Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.
Topics: Amino Acid Sequence; Anesthetics, Local; Animals; Binding Sites; Cysteine; Cytoplasm; Electrophysiology; Indicators and Reagents; Ion Channel Gating; Kinetics; Lidocaine; Mesylates; Mice; Molecular Sequence Data; Muscle, Skeletal; Mutagenesis, Site-Directed; Oocytes; Protein Conformation; Receptors, Cholinergic; Xenopus | 1998 |
A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel.
Topics: Anesthetics, Local; Animals; Binding Sites; Lidocaine; Muscle, Skeletal; Mutagenesis; Myocardium; NAV1.8 Voltage-Gated Sodium Channel; Protein Isoforms; Rats; Sodium Channels; Tetrodotoxin; Xenopus | 2000 |
Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.
Topics: Amino Acid Substitution; Anesthetics, Local; Animals; Calcium Channel Blockers; Cells, Cultured; Conotoxins; Ethyl Methanesulfonate; Ion Channel Gating; Lidocaine; Mesylates; Mutagenesis, Site-Directed; Oocytes; Patch-Clamp Techniques; Protein Isoforms; Rats; Saxitoxin; Sodium Channel Blockers; Sodium Channels; Structure-Activity Relationship; Tetrodotoxin; Transfection; Xenopus laevis | 2001 |
Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.
Topics: Amides; Anesthetics, Local; Animals; Bupivacaine; Dogs; Kidney Medulla; Lidocaine; Mepivacaine; Procaine; Protein Binding; Ropivacaine; Sodium Channels; Sodium-Potassium-Exchanging ATPase | 2001 |
Understanding channel blocking in the nicotinic acetylcholine receptor.
Topics: Acetylcholine; Animals; Binding Sites; Chlorisondamine; Ethidium; Hexamethonium; Lidocaine; Mice; Nicotinic Antagonists; Onium Compounds; Pempidine; Proadifen; Quinacrine; Receptors, Nicotinic; Trityl Compounds | 2001 |
Voltage-gated Na+ channels enhance the temporal filtering properties of electrosensory neurons in the torus.
Topics: Action Potentials; Animals; Electrophysiology; Excitatory Postsynaptic Potentials; Gymnotiformes; Lidocaine; Neurons, Afferent; Sodium Channel Blockers; Sodium Channels | 2003 |
The voltage dependence of recovery from use-dependent block by QX-222 separates mechanisms for drug egress in the cardiac sodium channel.
Topics: Cell Line; Cloning, Molecular; Electrophysiology; Genetic Vectors; Heart; Humans; Lidocaine; Models, Biological; Mutation; Plasmids; Protein Isoforms; Sodium Channels; Transfection | 2006 |
Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.
Topics: Anesthetics, Local; Anti-Arrhythmia Agents; Arginine; Binding Sites; Biotin; Cell Line; Cysteine; Dose-Response Relationship, Drug; Humans; Ion Channel Gating; Kinetics; Lidocaine; Membrane Potentials; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Protein Conformation; Protein Structure, Tertiary; Sodium Channel Blockers; Sodium Channels; Transfection | 2007 |
Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cyanobacteria; Diltiazem; Female; GABA-B Receptor Antagonists; gamma-Aminobutyric Acid; Humans; Intracellular Signaling Peptides and Proteins; Lidocaine; Membrane Potentials; Mice; Molecular Sequence Data; Mutation; Ondansetron; Oocytes; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-B; Receptors, Serotonin, 5-HT3; Sequence Homology, Amino Acid; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Sodium Chloride; Xenopus laevis | 2008 |
Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor.
Topics: Anesthetics; Animals; Etomidate; Female; Ion Channels; Lidocaine; Nicotinic Antagonists; Photoaffinity Labels; Protein Structure, Tertiary; Protein Subunits; Receptors, Nicotinic; Tritium; Xenopus laevis | 2009 |
Prolonged sensory-selective nerve blockade.
Topics: Anesthetics, Local; Animals; Drug Interactions; Injections, Subcutaneous; Lidocaine; Male; Nerve Block; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sensory Receptor Cells; Surface-Active Agents | 2010 |
The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle.
Topics: Animals; Caveolin 3; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lidocaine; Male; Membrane Potentials; Membrane Proteins; Neuromuscular Junction; Nicotinic Agonists; Nicotinic Antagonists; Phosphoproteins; Proadifen; Protein Binding; Rats; Rats, Wistar; Receptors, Nicotinic; Sarcolemma; Sodium-Potassium-Exchanging ATPase; Torpedo | 2010 |
Calcium permeable AMPA receptor-dependent long lasting plasticity of intrinsic excitability in fast spiking interneurons of the dentate gyrus decreases inhibition in the granule cell layer.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Biophysics; Calcium; Dentate Gyrus; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; In Vitro Techniques; Interneurons; Lidocaine; Male; Models, Neurological; Nerve Net; Patch-Clamp Techniques; Pyrimidines; Rats; Receptors, AMPA; Time Factors | 2015 |
Coapplication of lidocaine and membrane-impermeable lidocaine derivative QX-222 produces divergent effects on evoked and spontaneous nociceptive behaviors in mice.
Topics: Analgesics; Animals; Behavior, Animal; Drug Combinations; Humans; Lidocaine; Mice; Nociception; Pain; Pain Measurement; Sciatic Nerve | 2014 |
Functional Human α7 Nicotinic Acetylcholine Receptor (nAChR) Generated from Escherichia coli.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Escherichia coli; Escherichia coli Proteins; Humans; Isoxazoles; Lidocaine; Molecular Chaperones; Phencyclidine; Phenylurea Compounds; Recombinant Proteins; Xenopus | 2016 |