Compounds > quisqualic acid
Page last updated: 2024-08-23

quisqualic acid and 6-methyl-2-(phenylethynyl)pyridine

quisqualic acid has been researched along with 6-methyl-2-(phenylethynyl)pyridine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's8 (88.89)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1
Allgeier, H; Biollaz, M; Flor, PJ; Gasparini, F; Heckendorn, R; Heinrich, M; Hess, SD; Johnson, EC; Kuhn, R; Lingenhöhl, K; Rao, SP; Sacaan, AI; Santori, EM; Stoehr, N; Urwyler, S; Varney, MA; Veliçelebi, G; Vranesic, I1
Canonico, PL; Copani, A; de Grazia, U; Knöpfel, T; Nicoletti, F; Richelmi, P; Storto, M; Vairetti, M1
Diener, C; Fischer, C; Kratochwil, N; Kratzeisen, C; Malherbe, P; Piussi, J; Porter, RH; Zenner, MT1
Ahn, JY; Huang, H; Kalman, D; Kapp, JA; Nagata, E; Rong, R; Snyder, SH; Tu, J; Worley, PF; Ye, K1
Foster, AC; Naeve, GS; Selkirk, JV1
Battaglia, G; Capobianco, L; Cappuccio, I; De Vita, T; Desiderati, F; Melchiorri, D; Nicoletti, F; Porcellini, A; Spinsanti, P; Storto, M1
Fischer, C; Gerber, PR; Jaeschke, G; Kratochwil, N; Malherbe, P; Mühlemann, A; Porter, RH; Stahl, M; Zenner, MT1
Allgeier, H; Auberson, YP; Brülisauer, A; Gasparini, F; Hintermann, S; Hoyer, D; Lemaire, M; Moenius, T; Urwyler, S; Vranesic, I; Whitebread, S1

Reviews

1 review(s) available for quisqualic acid and 6-methyl-2-(phenylethynyl)pyridine

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

8 other study(ies) available for quisqualic acid and 6-methyl-2-(phenylethynyl)pyridine

ArticleYear
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
    Neuropharmacology, 1999, Volume: 38, Issue:10

    Topics: Animals; Animals, Newborn; Brain; Cell Line; Cyclic AMP; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lithium Chloride; Male; Methoxyhydroxyphenylglycol; Oocytes; Phosphatidylinositols; Pyridines; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sulfur Radioisotopes; Transfection; Xenopus laevis

1999
Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage.
    Hepatology (Baltimore, Md.), 2000, Volume: 31, Issue:3

    Topics: Animals; Animals, Newborn; Blotting, Western; Cell Hypoxia; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Agonists; Glycine; Immunohistochemistry; Liver; Male; Neuroprotective Agents; Pyridines; Quisqualic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured

2000
Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine.
    Molecular pharmacology, 2003, Volume: 64, Issue:4

    Topics: Allosteric Site; Amino Acid Sequence; Animals; Binding Sites; Calcium; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Point Mutation; Protein Structure, Tertiary; Pyridines; Quisqualic Acid; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rhodopsin; Sequence Homology, Amino Acid; Tritium

2003
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
    Nature neuroscience, 2003, Volume: 6, Issue:11

    Topics: Adenoviridae; Amino Acid Motifs; Amino Acid Sequence; Analysis of Variance; Androstadienes; Animals; Apoptosis; Blotting, Western; Brain; Carrier Proteins; Cell Fractionation; Cells, Cultured; Cloning, Molecular; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homer Scaffolding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; Leucine; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proline; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Synaptophysin; Transfection; Wortmannin

2003
Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors.
    Neuropharmacology, 2003, Volume: 45, Issue:7

    Topics: Animals; Aspartic Acid; Benzoates; Colforsin; Cyclic AMP; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glycine; Hippocampus; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Methoxyhydroxyphenylglycol; Pyridines; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate

2003
Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.
    Neuropharmacology, 2005, Volume: 49 Suppl 1

    Topics: Alanine Transaminase; Animals; Blotting, Northern; Blotting, Western; Brain; Calcium; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Gene Expression Regulation, Developmental; Glutamic Acid; Interleukin-6; Leukemia Inhibitory Factor; Mice; Neurons; Oligodeoxyribonucleotides, Antisense; Pyridines; Quisqualic Acid; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Thymidine; Time Factors; Tritium

2005
Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP.
    Journal of neurochemistry, 2006, Volume: 98, Issue:2

    Topics: Binding Sites; Calcium; Cell Line; Cell Membrane; Cells, Cultured; Excitatory Amino Acid Antagonists; Fluorometry; Humans; Imidazoles; Inositol Phosphates; Models, Molecular; Mutation; Plasmids; Pyridines; Quisqualic Acid; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles

2006
ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies.
    Bioorganic & medicinal chemistry, 2007, Jan-15, Volume: 15, Issue:2

    Topics: Animals; Autoradiography; Binding, Competitive; Blood Proteins; Cell Line; Chemical Phenomena; Chemistry, Physical; Cricetinae; Excitatory Amino Acid Agonists; Humans; In Vitro Techniques; Indicators and Reagents; Injections, Intravenous; Ligands; Male; Mass Spectrometry; Microsomes, Liver; Oximes; Phosphatidylinositols; Positron-Emission Tomography; Protein Binding; Pyridines; Quisqualic Acid; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Tissue Distribution

2007