quinuclidines has been researched along with thiophenes in 178 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (2.81) | 18.7374 |
| 1990's | 37 (20.79) | 18.2507 |
| 2000's | 67 (37.64) | 29.6817 |
| 2010's | 60 (33.71) | 24.3611 |
| 2020's | 9 (5.06) | 2.80 |
| Authors | Studies |
|---|---|
| Bartolini, A; Fantetti, L; Ghelardini, C; Giotti, A; Malcangio, M; Malmberg-Aiello, P | 1 |
| Freedman, SB; Hargreaves, RJ; Harley, EA; Hutson, PH; McKnight, AT; Newberry, NR; Patel, S; Scholey, K; Semark, JE; Street, LJ | 1 |
| Fisher, A; Segal, M | 1 |
| Sepinwall, J; Vincent, GP | 1 |
| Iversen, SD; Rupniak, NM; Tye, SJ | 1 |
| Harada, M; Hidaka, K; Konishi, T; Tamura, T; Terai, M; Tsukamoto, S; Usuda, S; Wanibuchi, F | 1 |
| Matsumoto, M; Saito, H; Saito, Y; Togashi, H; Yoshioka, M | 1 |
| Brandeis, R; Fisher, A; Gurwitz, D; Haring, R; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Fujise, N; Kawanishi, G; Mizobe, F; Nakahara, N | 1 |
| Brandeis, R; Dachir, S; Fisher, A; Levy, A; Sapir, M | 1 |
| Iga, Y; Kawanishi, G; Mizobe, F; Ogane, N; Takada, Y | 1 |
| Matsumoto, M; Morii, K; Saito, H; Togashi, H; Yoshioka, M | 1 |
| Brandeis, R; Dachir, S; Fisher, A; Grunfeld, Y; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Iga, Y; Kawanishi, G; Mizobe, F; Nakahara, N; Saito, Y | 1 |
| Kato, T; Mizobe, F; Xu, M; Yamamoto, T | 1 |
| Brandeis, R; Dachir, S; Fisher, A; Heldman, E; Karton, I; Levy, A; Pittel, Z; Sapir, M | 1 |
| Kawanishi, G; Mizobe, F; Ohgane, N; Ono, S; Saito, Y | 1 |
| Iga, Y; Kawanishi, G; Mizobe, F; Nakahara, N | 1 |
| Ohyama, M; Ozawa, Y; Suzuki, M; Yamaguchi, T; Yamamoto, M | 1 |
| Iwabuchi, Y; Masuhara, T | 1 |
| Barg, J; Danenberg, HD; Gurwitz, D; Haring, R; Heldman, E; Marciano, D; Meshulam, H; Pinkas-Kramarski, R; Pittel, Z; Wengier, A | 1 |
| Iwai, A; Ozawa, Y; Suzuki, M; Yamaguchi, T; Yamamoto, M | 1 |
| Fisher, A; Gurwitz, D; Haring, R; Heldman, E; Karton, Y; Pinkas-Kramarski, R; Stein, R | 1 |
| Hirokami, M; Matsumoto, M; Saito, H; Tochihara, M; Togashi, H; Yoshioka, M | 1 |
| Bayley, P; Channell, S; Dawson, GR; Iversen, SD | 1 |
| Furukawa, T; Katsuragi, T; Soejima, O | 1 |
| Ohno, M; Watanabe, S; Yamamoto, T | 1 |
| Barg, J; Gurwitz, D; Haring, R; Heldman, E; Karton, Y; Marciano, D; Meshulam, H; Pinkas-Kramarski, R; Pittel, Z; Wengier, A | 1 |
| Dawson, GR; Iversen, SD | 1 |
| Fisher, A; Fraser, CM; Gurwitz, D; Haring, R; Heldman, E; Manor, D | 1 |
| Brandeis, R; Fisher, A; Gurwitz, D; Haring, R; Heldman, E; Karton, Y; Marciano, D; Meshulam, H; Pittel, Z; Segall, Y | 1 |
| Saito, Y | 1 |
| Barg, J; Behar, L; Fisher, A; Ginzburg, I; Gurwitz, D; Sadot, E | 1 |
| Barg, Y; Brandeis, R; Fisher, A; Ginzburg, I; Gurwitz, D; Haring, R; Heldman, E; Karton, Y; Klimowsky, S; Korczyn, AD; Marciano, D; Meshulam, H; Pinkas-Kramarski, R; Pittel, Z; Sadot, E; Treves, TA; Verchovsky, R; Vogel, Z | 1 |
| Arisawa, H; Iga, Y; Ise, M; Takeshita, Y; Yasuda, H | 1 |
| Ikeda, T | 1 |
| Masunaga, H; Ogawa, H; Takeshita, Y; Tomizuka, T; Uematsu, Y; Yasuda, H | 1 |
| Fisher, A; Fitten, LJ; Halgren, E; Kim, E; O'Neill, J; Perryman, K; Siembieda, D | 1 |
| Arisawa, H; Iga, Y; Masunaga, H; Miyata, N; Nakagawa-Yagi, Y; Ogane, N; Saito, Y; Tomizuka, T; Yasuda, H | 1 |
| Fisher, A; Fitten, LJ; Halgren, E; O'Neill, J; Ortiz, F; Siembieda, DW | 1 |
| Crawford, KC; Fisher, A; Fitten, LJ; Halgren, E; O'Neill, J; Refai, D; Siembieda, DW | 1 |
| Anaya, JM; Talal, N | 1 |
| Ishida, H; Ishikawa, Y; Skowronski, MT | 1 |
| Bartolini, A; Galeotti, N; Ghelardini, C | 1 |
| Deng, M; Growdon, JH; Nitsch, RM; Schoenfeld, D; Tennis, M | 1 |
| Fox, RI; Michelson, P | 1 |
| al-Hashimi, I; Taylor, SE | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Atkinson, JC; Baum, BJ | 1 |
| Arisawa, H; Kohsaka, K; Washio, T; Yasuda, H | 1 |
| Fisher, A; Fox, RI; Konttinen, Y | 1 |
| Arisawa, H; Fujise, N; Fukui, K; Imai, E; Masunaga, H | 2 |
| Arisawa, H; Fujise, N; Fukui, K; Masunaga, H | 1 |
| Cohen, S; Condemi, JJ; Dalgin, P; Fife, R; Gluck, O; Petrone, D | 1 |
| Arisawa, H; Fukui, K; Masunaga, H | 1 |
| Muzyka, BC | 1 |
| Chase, WF; Dore, RK; Fife, RS; Lockhart, PB; Suen, JY; Tindall, E; Wiesenhutter, CW | 1 |
| Shiozawa, A | 1 |
| Arisawa, H; Kohsaka, K; Masunaga, H; Washio, T | 1 |
| Fox, RI | 1 |
| Iida, H; Inoue, N; Ishida, H; Ishikawa, Y; Yuan, Z | 2 |
| Arisawa, H; Kohsaka, K; Masunaga, H; Nagatsuka, S; Satoh, Y; Washio, T | 1 |
| Nieuw Amerongen, AV; Veerman, EC | 1 |
| Asari, T; Kojima, M; Kusama, H; Maruyama, K; Omori, Y; Shibata, N | 1 |
| Bar-Ner, N; Brandeis, R; Egozi, I; Fisher, A; Haring, R; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H | 1 |
| Crawford, KC; Fisher, A; Fitten, LJ; Halgren, E; O'Neill, J; Siembieda, DW | 1 |
| Gurwitz, D; Haring, R | 1 |
| Bruce, SD | 1 |
| Kimura, Y; Nakamura, T; Takagi, Y | 1 |
| Hanzawa, M; Iikuni, N; Nishinarita, M; Ota, S | 1 |
| Hamano, T; Ono, M; Shinozaki, K; Takamura, E; Tsubota, K; Tsumura, T; Yagi, Y | 1 |
| Hsieh, M; Kershen, RT | 1 |
| Aframian, DJ; Nahlieli, O; Palmon, A | 1 |
| Fukushima, T; Hirose, Y; Karasawa, H; Masaki, Y; Ogawa, N; Shimoyama, K; Sugai, S; Wano, Y | 1 |
| Matsumoto, M; Nakanishi, T; Nakashima, M; Ohsuzu, F; Okada, M; Suzuki, K; Takada, K | 1 |
| Shetty, K | 2 |
| Atkinson, JC; Grisius, M; Massey, W | 1 |
| Kitano, M; Ogata, A; Sano, H | 1 |
| Chu, DS; Kapila, R; Wladis, EJ | 1 |
| Agre, P; Cho, G; Inoue, N; Ishikawa, Y; Nakae, Y; Nielsen, S; Shono, M; Skowronski, MT; Yasui, M; Yuan, Z | 1 |
| Al-Hashimi, I | 1 |
| Johnstone, PA; Kahn, ST | 1 |
| Carpenter, PA; Flowers, ME; Schubert, MM | 1 |
| Haga, K; Inenaga, K; Ono, K; Sato, N; Yokota, M | 1 |
| Mishima, K; Nakagawa, Y; Nomura, Y; Saito, I; Sumida, T; Wakamatsu, E; Yamachika, S; Yamada, H | 1 |
| Gause, A | 1 |
| Cardozo, L; Cartwright, R; Robinson, D; Vella, M | 1 |
| Brennan, MT; Carrozzo, M; Daniels, T; Fox, PC; Fujibayashi, T; Gandera, B; Jonsson, R; Lockhart, PB; Navazesh, M; Rhodus, NL; Schiødt, M; Sollecito, TP; von Bültzingslöwen, I; Wray, D | 1 |
| Armstrong, I; Biel, MA; Chambers, MS; Hodge, KM; Jones, CU; Posner, M; Vitti, R; Weber, RS; Yen, C | 1 |
| Armstrong, I; Biel, MA; Chambers, MS; Chen, Y; Garden, AS; Haddad, R; Hodge, KM; Holland, JM; Jones, CU; Ship, JA; Vitti, R; Weber, RS | 1 |
| Lau, CS; Leung, KC; Leung, WK; McMillan, AS; Mok, MY; Wong, MC | 1 |
| Chiba, T; Inomata, M; Kudara, N; Orii, S; Sato, M; Suzuki, K | 1 |
| Hanaue, N; Kizu, Y; Takaki, S; Takakura, K; Takeda, I; Tonogi, M; Yamane, GY | 1 |
| Wick, JY | 1 |
| Akamatsu, T; Azlina, A; Hasegawa, T; Hosoi, K; Karabasil, MR; Li, X; Purwanti, N; Yao, C | 1 |
| Keating, GM; Weber, J | 1 |
| Cho, G; Ishikawa, Y; Iwata, F; Kang, J; Li, XJ; Mori, T; Muraguchi, M; Ohmoto, Y; Okamura, K; Ooga, K; Pan, Y; Shono, M; Takai, M; Wang, D | 1 |
| Katayama, I; Nakamura, T; Takagi, Y; Tashiro, S | 1 |
| Andrade, ED; Bergamaschi, CC; Braga, MA; Groppo, FC; Santos, FA; Tarzia, O | 1 |
| Hashiramoto, A; Komai, K; Murata, M; Sakai, H; Shiozawa, K; Shiozawa, S; Tanaka, C; Tanaka, Y; Tsumiyama, K; Yamane, T; Yoshihara, R | 1 |
| Kamada, M; Kanamaru, T; Konno, T; Makoto, K; Nakagami, H; Tajiri, S | 1 |
| Bencherif, M; Hauser, TA; Lippiello, PM; Lucas, R; Marrero, MB; Mazurov, A; Salet, C | 1 |
| Ichikawa, H; Kobashi, M; Matsuo, R; Mitoh, Y; Ueda, H; Yamashiro, T | 1 |
| Ishikawa, Y; Iwata, F; Mori, T; Muraguchi, M; Ohmoto, Y; Ooga, K; Takai, M; Wang, D | 1 |
| Hosokawa, R; Iida, T; Inagaki, T; Inenaga, K; Ono, K | 1 |
| Nishimura, H; Saga, T; Yakeishi, A; Yamaki, K | 1 |
| Goto, D; Hayashi, T; Iizuka, M; Ito, S; Matsumoto, I; Nakamura, Y; Sumida, T; Tsuboi, H; Wakamatsu, E | 1 |
| Babu, K; Hack, JB; Voskoboynik, B | 1 |
| Hosoi, Y; Kanamaru, T; Konno, T; Nakagami, H; Tajiri, S; Yada, S; Yoshida, K | 1 |
| Colucci, M; Di Giannuario, A; Maione, F; Mascolo, N; Mastriota, M; Palmery, M; Perretti, M; Pieretti, S; Severini, C | 1 |
| Hosokawa, R; Kidokoro, M; Kondo, Y; Masaki, C; Mukaibo, T; Nakamoto, T | 1 |
| Cho, G; Inoue, N; Ishikawa, Y; Shono, M; Wang, D; Yuan, Z | 1 |
| Adyanthaya, RS; Akpek, EK; Baer, AN; Lindsley, KB; McDonnell, PJ; Swamy, R | 1 |
| Bertrand, D; Bertrand, S; Boess, FG; Chesworth, R; Flood, DG; Gawryl, M; Hilt, D; König, G; Methfessel, C; Prickaerts, J; Reneerkens, OA; Shapiro, G; van Goethem, NP | 1 |
| Hosokawa, R; Iida, T; Inagaki, T; Inenaga, K; Ono, K; Wakasugi-Sato, N | 1 |
| Choy, ML; Lee, JH; Marks, PA; Ngo, L; Venta-Perez, G | 1 |
| Chambers, MS; Stinnett, S; Witsell, DL | 1 |
| Bencherif, M; Kucinski, A; Stachowiak, EK; Stachowiak, MK; Syposs, C; Wersinger, S | 1 |
| Greenfield, NP; Maibach, H | 1 |
| Chambon, C; Danysz, W; Gravius, A; Jatzke, C; Wegener, N | 1 |
| Green, H; James, JW; Jordan, KG; Letchworth, SR; Loram, LC; Maier, SF; Mazarov, A; Pritchard, RC; Speake, JD; Strand, KA; Taylor, FR; Van Dyke, K; Watkins, LR; Wene, SP | 1 |
| Hara, S; Ogata, K; Takamatsu, Y; Tamura, K; Yoshikawa, C | 1 |
| Chimenos Küstner, E; Jané Salas, E; López-López, J | 1 |
| Kusukawa, J; Nakamura, M; Saga, T; Tabira, Y; Takahashi, N; Watanabe, K; Yamaki, K | 1 |
| Bencherif, M; Birkaya, B; Klejbor, I; Lee, YW; Morys, J; Narla, S; Stachowiak, EK; Stachowiak, MK; Terranova, C | 1 |
| Bencherif, M; Birkaya, B; Klejbor, I; Lee, YW; Morys, J; Narla, ST; Prokop, D; Stachowiak, EK; Stachowiak, MK | 1 |
| Davis, RM; Grubbs, J; Huynh, K; Liu, KC | 1 |
| Bauer, LO; Dgetluck, N; Gawryl, M; Hilt, DC; Palfreyman, M; Preskorn, SH | 1 |
| Preskorn, SH | 1 |
| Bhuvaneswaran, C; Felix, AR; Flood, DG; Hilt, D; Huang, M; Koenig, G; Meltzer, HY | 1 |
| Parachikova, AI; Pedersen, CS; Plath, N; Sørensen, DB | 1 |
| Bencherif, M; Budygin, E; Grinevich, V; Grinevich, VP; Gutkin, B; Maex, R | 1 |
| Hashimoto, K | 1 |
| Matera, C; Tata, AM | 1 |
| Barbier, AJ; Dgetluck, N; Gawryl, M; Hilhorst, M; Hilt, DC; Massaro, M; Palfreyman, MG; Snyder, P; Tiessen, R; Timmerman, W; Van Vliet, A | 1 |
| Deardorff, WJ; Grossberg, GT; Shobassy, A | 1 |
| Flood, DG; Koenig, G; Prickaerts, J; van Goethem, NP; Welty, D | 1 |
| Akdemir, A; Bozdag, M; Carta, F; Isik, S; Lanzi, C; Masini, E; Scozzafava, A; Supuran, CT; Vullo, D | 1 |
| Hao, Y; Tang, J; Wang, K | 1 |
| Chadha, AS; Fisher, A; Hoey, SE; Kulic, L; McAfoose, J; Nitsch, RM; Späni, C; Welt, T | 1 |
| Dgetluck, N; Gawryl, M; Hilt, DC; Keefe, RS; Koenig, G; Lombardo, I; Meltzer, HA; Moebius, HJ | 1 |
| Bertrand, D; Chen, A; Chen, T; Driscoll, R; Flood, D; Hajós, M; Hodgdon, H; Hurst, R; Koenig, G; Leventhal, L; Nagy, D; Piser, T; Stoiljkovic, M; Tang, C; Townsend, M; Tu, Z | 1 |
| Habara, Y; Moustafa, A | 1 |
| Kawakami, A; Nakamura, H; Nakamura, T; Sato, S; Sumi, M; Takagi, Y | 1 |
| Blomster, LV; Cygankiewicz, AI; Fichna, J; Jacenik, D; Krajewska, WM; Mikkelsen, JD; Piechota-Polańczyk, A; Salaga, M; Zielińska, M | 1 |
| Bizdēna, Ē; Bogans, J; Čerkasovs, M; Fotins, J; Grigaloviča, A; Kumpiņš, V; Meri, RM; Mishnev, A; Novosjolova, I; Rāviņa, I; Stepanovs, D; Tetere, Z; Turks, M; Zicāne, D | 1 |
| Hajós, M; Kelley, C; Leventhal, L; Nagy, D; Stoiljkovic, M | 1 |
| Hajós, GP; Hajós, M; Kelley, C; Koenig, G; Leventhal, L; Nagy, D; Stoiljkovic, M | 1 |
| Flood, DG; Jeggo, R; Koenig, G; Leventhal, L; Patzke, H; Townsend, M; van den Top, M; Walczak, JS; Whyment, A | 1 |
| Hajós, M; Hurst, R; Kelley, C; Nagy, D; Stoiljkovic, M | 1 |
| Asbell, PA; Kuklinski, E | 1 |
| Dineley, KT; Dunphy, JM; Haydon, PG; Papouin, T; Tolman, M | 1 |
| Fujita, M; Ichikawa, H; Kobashi, M; Matsuo, R; Mitoh, Y; Ueda, H | 1 |
| Barbe, AG | 2 |
| Benitex, Y; Bookbinder, M; Bristow, LJ; Keavy, D; King, D; Macor, JE; Morgan, DG; Olson, R; Polino, J; Signor, L; Weed, MR; Zaczek, R | 1 |
| Forbes, B; Garcia, CMA; Malallah, OS; Proctor, GB; Royall, PG | 1 |
| Miyake, H; Sasano, T; Satoh-Kuriwada, S; Shoji, N; Watanabe, C | 1 |
| Cherubini, K; Figueiredo, MAZ; Medella-Junior, FAC; Salum, FG | 1 |
| Bakshi, R; Cahill, CM; Rogers, JT; Wong, A; Xia, N | 1 |
| B E, S; Badam, RK; Boringi, M; Garlapati, K; Kammari, A; Soni, P | 1 |
| Chen, CH; Chou, YC; Huang, WY; Ju, UH; Kao, CH; Lin, CL; Lin, CS; Lin, KT; Lin, TY; Liu, FC; Shen, CH; Yang, TY | 1 |
| Cecon, E; Chollet, AM; Dam, J; Danober, L; Delagrange, P; Gautier, C; Jockers, R; Luka, M | 1 |
| Cimmino, J; Farag, AM; Holliday, C; Papas, A; Roomian, T | 1 |
| Cho, N; Hara, H; Hoffman, I; Homma, M; Imada, T; Iwai, K; Iwata, K; Kurasawa, O; Miyazaki, T; Nomura, T; Oguro, Y; Ohashi, A; Ohori, M; Skene, R; Sugimoto, H; Uchiyama, N; Yamamoto, Y | 1 |
| Deng, C; Lian, J | 1 |
| Beck, WD; Blake, DT; Callahan, PM; Plagenhoef, MR; Terry, AV | 1 |
| Isola, M; Isola, R; Loy, F; Masala, C | 1 |
| Hwang, MW; Kim, CE; Kim, YJ; Park, YJ; Yang, J | 1 |
| Hort, J; Klimova, B; Kuca, K; Nepovimova, E; Novotny, M; Oleksak, P; Patocka, J; Pavlik, J; Valis, M | 1 |
| Deng, C; Han, M; Lian, J; Su, Y | 1 |
| Graue-Hernandez, EO; Kahuam-López, N; Navas, A; Pérez Vázquez, AK; Ramirez-Miranda, A; Serrano-Robles, JG | 1 |
| Acquarulo, B; Macica, CM; Tandon, P | 1 |
31 review(s) available for quinuclidines and thiophenes
| Article | Year |
|---|---|
AF102B: rational treatment strategy for Alzheimer's disease: recent advances.
Topics: Alzheimer Disease; Humans; Parasympathomimetics; Quinuclidines; Thiophenes | 1990 |
Progress in medicinal chemistry of novel selective muscarinic agonists.
Topics: Acetylcholine; Alzheimer Disease; Animals; Chemistry, Pharmaceutical; Humans; Parasympathomimetics; Protein Conformation; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1993 |
M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; GTP-Binding Proteins; Humans; Ligands; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phosphorylation; Pyridines; Quinuclidines; Rats; Receptors, Cholinergic; Signal Transduction; tau Proteins; Thiadiazoles; Thiophenes | 1996 |
Sjögren's syndrome comes of age.
Topics: Apoptosis; Humans; Lymphocytosis; Muscarinic Agonists; Pilocarpine; Quinuclidines; Receptors, Muscarinic; Salivary Glands; Sjogren's Syndrome; Thiophenes | 1999 |
Approaches to the treatment of Sjögren's syndrome.
Topics: Humans; Muscarinic Agonists; Pilocarpine; Quinuclidines; Sjogren's Syndrome; Thiophenes | 2000 |
Use of muscarinic agonists in the treatment of Sjögren's syndrome.
Topics: Humans; Muscarinic Agonists; Neuroimmunomodulation; Neurosecretory Systems; Pilocarpine; Quinuclidines; Receptors, Muscarinic; Sjogren's Syndrome; Thiophenes | 2001 |
[Cevimeline hydrochloride hydrate (Saligren capsule 30 mg): a review of its pharmacological profiles and clinical potential in xerostomia].
Topics: Adult; Animals; Humans; Male; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Thiophenes | 2002 |
Use of cevimeline, a muscarinic M1 and M3 agonist, in the treatment of Sjögren's syndrome.
Topics: Humans; Muscarinic Agonists; Quinuclidines; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, Muscarinic; Sjogren's Syndrome; Thiophenes | 2002 |
Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies.
Topics: Acupuncture Therapy; Antineoplastic Agents; Chewing Gum; Diet; Flavoring Agents; Humans; Muscarinic Agonists; Neoplasms; Oral Hygiene; Palliative Care; Parasympathomimetics; Pilocarpine; Quinuclidines; Radiotherapy; Saliva; Salivary Glands; Thiophenes; Xerostomia | 2003 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
Radiation-induced xerostomia: how dry is your patient?
Topics: Acupuncture Therapy; Head and Neck Neoplasms; Humans; Muscarinic Agonists; Nurse's Role; Nursing Assessment; Oncology Nursing; Oral Hygiene; Pilocarpine; Quality of Life; Quinuclidines; Radiotherapy; Radiotherapy Dosage; Salivation; Thiophenes; Xerostomia | 2004 |
Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine.
Topics: Benzilates; Benzofurans; Clinical Trials as Topic; Duloxetine Hydrochloride; Humans; Muscarinic Antagonists; Nortropanes; Pyrrolidines; Quinuclidines; Selective Serotonin Reuptake Inhibitors; Solifenacin Succinate; Tetrahydroisoquinolines; Thiophenes; Urinary Incontinence | 2004 |
Salivary hypofunction and xerostomia: diagnosis and treatment.
Topics: Aged; Aged, 80 and over; Cariostatic Agents; Fluorides; Humans; Pilocarpine; Polypharmacy; Quinuclidines; Radiotherapy; Salivation; Sjogren's Syndrome; Thiophenes; Xerostomia | 2005 |
Xerostomia secondary to Sjögren's syndrome in the elderly: recognition and management.
Topics: Aged; Aged, 80 and over; Diagnosis, Differential; Humans; Muscarinic Agonists; Pilocarpine; Quinuclidines; Sjogren's Syndrome; Thiophenes; Xerostomia | 2005 |
Management of xerostomia related to radiotherapy for head and neck cancer.
Topics: Acupuncture Therapy; Amifostine; Clinical Trials as Topic; Head and Neck Neoplasms; Humans; Muscarinic Agonists; Palliative Care; Pilocarpine; Quinuclidines; Radiation-Protective Agents; Radiotherapy; Submandibular Gland; Thiophenes; Xerostomia | 2005 |
New developments in the treatment of urinary incontinence.
Topics: Administration, Cutaneous; Adrenergic Uptake Inhibitors; Benzofurans; Drug Therapy, Combination; Duloxetine Hydrochloride; Humans; Mandelic Acids; Muscarinic Antagonists; Pyrrolidines; Quality of Life; Quinuclidines; Solifenacin Succinate; Tetrahydroisoquinolines; Thiophenes; Treatment Outcome; Urinary Bladder, Overactive; Urinary Incontinence, Stress | 2006 |
Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Diabetes Complications; HIV Infections; Humans; Interferon-alpha; Muscarinic Agonists; Pilocarpine; Quinuclidines; Rituximab; Salivation; Sjogren's Syndrome; Thiophenes; Xerostomia | 2007 |
Xerostomia: causes and treatment.
Topics: Autoimmune Diseases; Bone Marrow Transplantation; Drug-Related Side Effects and Adverse Reactions; Humans; Pilocarpine; Quinuclidines; Saliva; Thiophenes; Xerostomia | 2007 |
Treatment of Sjögren's syndrome-associated dry eye an evidence-based review.
Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents; Dry Eye Syndromes; Evidence-Based Medicine; Humans; Hydroxychloroquine; Immunosuppressive Agents; Lubricants; Pilocarpine; Quinuclidines; Sjogren's Syndrome; Thiophenes | 2011 |
[Prognosis and treatment of dry mouth. Systematic review].
Topics: Cholinergic Antagonists; Clinical Trials as Topic; Dental Caries; Disease Susceptibility; Double-Blind Method; Fluid Therapy; Humans; Meta-Analysis as Topic; Mouthwashes; Observational Studies as Topic; Pilocarpine; Prognosis; Quinuclidines; Radiation Injuries; Radiotherapy; Saliva, Artificial; Salivation; Sjogren's Syndrome; Thiophenes; Xerostomia | 2014 |
α7 nicotinic receptor agonist reactivates neurogenesis in adult brain.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Neurogenesis; Neurons; Nicotinic Agonists; Quinuclidines; Thiophenes | 2013 |
Autoimmunity in the pathogenesis and treatment of keratoconjunctivitis sicca.
Topics: Animals; Antigen-Presenting Cells; Apoptosis; Autoantibodies; Autoimmunity; Cyclosporine; Genetic Predisposition to Disease; Humans; Immunity, Cellular; Immunity, Humoral; Keratoconjunctivitis Sicca; Molecular Mimicry; Quinuclidines; Sjogren's Syndrome; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thiophenes | 2014 |
Pharmacological approaches to targeting muscarinic acetylcholine receptors.
Topics: Alzheimer Disease; Animals; Humans; Muscarinic Agonists; Pyridines; Quinuclidines; Receptors, Muscarinic; Sjogren's Syndrome; Thiadiazoles; Thiophenes | 2014 |
Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials, Phase III as Topic; Humans; Nicotinic Agonists; Quinuclidines; Thiophenes | 2015 |
Sjogren's syndrome from the perspective of ophthalmology.
Topics: Administration, Ophthalmic; Cyclosporine; Dry Eye Syndromes; Fatty Acids, Omega-3; Glucocorticoids; Humans; Immunosuppressive Agents; Lubricant Eye Drops; Muscarinic Agonists; Ophthalmology; Phenylalanine; Pilocarpine; Punctal Plugs; Quinuclidines; Sjogren's Syndrome; Sulfones; Thiophenes | 2017 |
Buccal drug delivery technologies for patient-centred treatment of radiation-induced xerostomia (dry mouth).
Topics: Drug Delivery Systems; Head and Neck Neoplasms; Humans; Mouth Mucosa; Muscarinic Agonists; Pilocarpine; Quinuclidines; Radiation Injuries; Saliva; Thiophenes; Time Factors; Xerostomia | 2018 |
Salivary hypofunction: An update on therapeutic strategies.
Topics: Acupuncture Therapy; Bethanechol; Chewing Gum; Humans; Hyperbaric Oxygenation; Muscarinic Agonists; Pilocarpine; Quinuclidines; Thiophenes; Xerostomia | 2018 |
Medication-Induced Xerostomia and Hyposalivation in the Elderly: Culprits, Complications, and Management.
Topics: Aged; Humans; Polypharmacy; Prevalence; Quality of Life; Quinuclidines; Saliva; Thiophenes; Xerostomia | 2018 |
Targeting the Iron-Response Elements of the mRNAs for the Alzheimer's Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity.
Topics: 5' Untranslated Regions; Acute Disease; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Down Syndrome; Ferritins; Humans; Iron; Iron-Regulatory Proteins; Lead Poisoning, Nervous System; Manganese Poisoning; Mice; Muscarinic Agonists; Neurons; Protein Biosynthesis; Quinuclidines; Rats; Response Elements; RNA, Messenger; Thiophenes | 2019 |
Meta-analysis on pharmacological therapies in the management of xerostomia in patients with Sjogren's syndrome.
Topics: Female; Humans; Interferon-alpha; Male; Pilocarpine; Quinuclidines; Saliva; Sjogren's Syndrome; Thiophenes | 2019 |
Neuropharmacology of Cevimeline and Muscarinic Drugs-Focus on Cognition and Neurodegeneration.
Topics: Animals; Cognition Disorders; Humans; Muscarinic Agonists; Neurodegenerative Diseases; Neuropharmacology; Pharmaceutical Preparations; Quinuclidines; Thiophenes | 2021 |
18 trial(s) available for quinuclidines and thiophenes
| Article | Year |
|---|---|
M1 agonists for the treatment of Alzheimer's disease. Novel properties and clinical update.
Topics: Alzheimer Disease; Animals; Clinical Trials as Topic; GTP-Binding Proteins; Humans; Ligands; Muscarinic Agonists; Nerve Growth Factors; PC12 Cells; Phosphorylation; Pyridines; Quinuclidines; Rats; Receptors, Cholinergic; Signal Transduction; tau Proteins; Thiadiazoles; Thiophenes | 1996 |
A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Keratoconjunctivitis Sicca; Male; Middle Aged; Muscarinic Agonists; Placebos; Quinuclidines; Safety; Saliva; Sjogren's Syndrome; Tears; Thiophenes; Xerostomia | 2002 |
Cevimeline for the treatment of xerostomia in patients with Sjögren syndrome: a randomized trial.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Thiophenes; Xerostomia | 2002 |
General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 4th communication: Effects on gastrointestinal, urinary and reproductive systems and other effects.
Topics: Animals; Anti-Inflammatory Agents; Cardiovascular System; Cross-Over Studies; Digestive System; Dogs; Female; Guinea Pigs; Male; Mice; Mice, Inbred ICR; Muscarinic Agonists; Pregnancy; Quinuclidines; Rabbits; Rats; Rats, Wistar; Reproduction; Sjogren's Syndrome; Thiophenes; Urogenital System; Xerostomia | 2002 |
Pharmacokinetics and metabolism of radiolabelled SNI-2011, a novel muscarinic receptor agonist, in healthy volunteers. Comprehensive understanding of absorption, metabolism and excretion using radiolabelled SNI-2011.
Topics: Adult; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Feces; Humans; Hydrolysis; Isotope Labeling; Male; Mass Spectrometry; Muscarinic Agonists; Quinuclidines; Thiophenes | 2003 |
Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.
Topics: Conjunctiva; Double-Blind Method; Epithelial Cells; Epithelium, Corneal; Female; Fluorophotometry; Humans; Male; Middle Aged; Muscarinic Agonists; Patient Compliance; Prospective Studies; Quinuclidines; Rose Bengal; Safety; Sjogren's Syndrome; Tears; Thiophenes; Treatment Outcome | 2004 |
Effect of cevimeline on salivary components in patients with Sjögren syndrome.
Topics: alpha-Amylases; Antigens, Neoplasm; Female; Humans; Immunoglobulin A; Middle Aged; Muramidase; Muscarinic Agonists; Quinuclidines; Saliva; Salivation; Serpins; Sjogren's Syndrome; Thiophenes; Xerostomia | 2005 |
Efficacy prediction of cevimeline in patients with Sjögren's syndrome.
Topics: Adult; Aged; Female; Humans; Middle Aged; Parasympathomimetics; Parotid Gland; Prognosis; Quinuclidines; Receptors, Muscarinic; Salivation; Sialography; Sjogren's Syndrome; Thiophenes; Treatment Outcome; Xerostomia | 2007 |
Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer.
Topics: Double-Blind Method; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Muscarinic Antagonists; Quinuclidines; Salivation; Thiophenes; Xerostomia | 2007 |
The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study.
Topics: Adult; Aged; Aged, 80 and over; China; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Health Surveys; Humans; Middle Aged; Muscarinic Agonists; Oral Health; Patient Satisfaction; Quality of Life; Quinuclidines; Severity of Illness Index; Sjogren's Syndrome; Thiophenes; Xerostomia | 2008 |
Parotid irrigation and cevimeline gargle for treatment of xerostomia in Sjögren's syndrome.
Topics: Humans; Mouthwashes; Parasympathomimetics; Parotid Gland; Quinuclidines; Sjogren's Syndrome; Steroids; Therapeutic Irrigation; Thiophenes; Xerostomia | 2008 |
Comparison of the effects of pilocarpine and cevimeline on salivary flow.
Topics: Administration, Oral; Adult; Cross-Over Studies; Humans; Male; Muscarinic Agonists; Physical Stimulation; Pilocarpine; Quinuclidines; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Saliva; Salivary Glands; Secretory Rate; Single-Blind Method; Thiophenes; Time Factors; Young Adult | 2009 |
Effectiveness of cevimeline to improve oral health in patients with postradiation xerostomia.
Topics: Carcinoma, Squamous Cell; Double-Blind Method; Female; Head and Neck Neoplasms; Humans; Male; Muscarinic Agonists; Oral Health; Quality of Life; Quinuclidines; Radiotherapy; Salivary Glands; Severity of Illness Index; Thiophenes; Xerostomia | 2012 |
[A study of the sialogogic effect of cevimeline gargle].
Topics: Adult; Female; Humans; Male; Quinuclidines; Salivation; Thiophenes; Young Adult | 2013 |
Normalizing effects of EVP-6124, an α-7 nicotinic partial agonist, on event-related potentials and cognition: a proof of concept, randomized trial in patients with schizophrenia.
Topics: Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Antipsychotic Agents; Cognition; Cognition Disorders; Double-Blind Method; Drug Therapy, Combination; Evoked Potentials; Female; Humans; Male; Middle Aged; Quinuclidines; Schizophrenia; Thiophenes; Treatment Outcome; Young Adult | 2014 |
Pharmacodynamics, pharmacokinetics, safety, and tolerability of encenicline, a selective α7 nicotinic receptor partial agonist, in single ascending-dose and bioavailability studies.
Topics: Administration, Oral; Adult; Biological Availability; Capsules; Cognition; Cross-Over Studies; Double-Blind Method; Fasting; Female; Food-Drug Interactions; Healthy Volunteers; Humans; Male; Nicotinic Agonists; Quinuclidines; Receptors, Nicotinic; Sex Factors; Therapeutic Equivalency; Thiophenes | 2015 |
Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia.
Topics: Adolescent; Adult; alpha7 Nicotinic Acetylcholine Receptor; Antipsychotic Agents; Cognition; Cognition Disorders; Double-Blind Method; Female; Humans; Male; Middle Aged; Nicotinic Agonists; Psychiatric Status Rating Scales; Psychotropic Drugs; Quinuclidines; Schizophrenia; Schizophrenic Psychology; Thiophenes; Treatment Outcome; Young Adult | 2015 |
Effects and Mechanisms of Tastants on the Gustatory-Salivary Reflex in Human Minor Salivary Glands.
Topics: Adult; Female; Humans; Male; Mouth Mucosa; Quinuclidines; Reflex; Salivary Glands, Minor; Salivation; Sodium Glutamate; Taste; Thiophenes; Tongue | 2018 |
130 other study(ies) available for quinuclidines and thiophenes
| Article | Year |
|---|---|
Role of muscarinic receptor subtypes in central antinociception.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Analgesia; Animals; Male; Mice; Pain Measurement; Pirenzepine; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1992 |
L-689,660, a novel cholinomimetic with functional selectivity for M1 and M3 muscarinic receptors.
Topics: Animals; Binding Sites; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Ganglia, Sympathetic; Lacrimal Apparatus; Male; Myocardium; Parasympathomimetics; Pyrazines; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Succinimides; Thiophenes | 1992 |
AF102B, a muscarinic M1 receptor agonist, mimics some effects of acetylcholine on neurons of rat hippocampus slices.
Topics: Acetylcholine; Animals; Atropine; Electrophysiology; Hippocampus; In Vitro Techniques; Parasympathomimetics; Pirenzepine; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1992 |
AF102B, a novel M1 agonist, enhanced spatial learning in C57BL/10 mice with a long duration of action.
Topics: Animals; Dose-Response Relationship, Drug; Learning; Male; Mice; Mice, Inbred C57BL; Quinuclidines; Receptors, Muscarinic; Spatial Behavior; Thiophenes; Time Factors | 1992 |
Comparison of the effects of selective and nonselective muscarinic agonists on cognition and thermoregulation in primates.
Topics: Animals; Body Temperature Regulation; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cognition; Macaca mulatta; Male; Memory; Parasympathomimetics; Piperazines; Pyrazines; Quinuclidines; Receptors, Muscarinic; Saimiri; Scopolamine; Space Perception; Succinimides; Thiophenes | 1992 |
Pharmacological studies on novel muscarinic agonists, 1-oxa-8-azaspiro[4.5]decane derivatives, YM796 and YM954.
Topics: Animals; Avoidance Learning; Hippocampus; Hydrolysis; Hypothermia; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Parasympathomimetics; Phosphatidylinositols; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Scopolamine; Spiro Compounds; Succinimides; Thiophenes; Tremor | 1990 |
Effects of a novel cholinergic M1 agonist, AF102B, on ambulation and water drinking behavior in rats.
Topics: Animals; Drinking Behavior; Locomotion; Male; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Thiophenes | 1991 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine, an M1 selective cholinergic agonist, attenuates cognitive dysfunctions in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Binding, Competitive; Cognition Disorders; Copper; Disease Models, Animal; Male; Memory; Mice; Motor Activity; Parasympathomimetics; Pilocarpine; Quinuclidines; Quinuclidinyl Benzilate; Receptors, Muscarinic; Thiophenes | 1991 |
Central muscarinic activities of an M1-selective agonist: preferential effect on reversal of amnesia.
Topics: Animals; Avoidance Learning; Hypothermia; Male; Memory; Mice; Oxotremorine; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1990 |
Reversal of age-related cognitive impairments by an M1 cholinergic agonist, AF102B.
Topics: Aging; Animals; Learning; Male; Memory; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Thiophenes | 1990 |
Effects of a M1 muscarinic receptor agonist on the central cholinergic system, evaluated by brain microdialysis.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Dialysis; Hippocampus; Kinetics; Male; Oxotremorine; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Scopolamine; Thiophenes; Time Factors | 1990 |
Sympathoexcitatory action of a novel muscarinic receptor agonist, AF102B, and its blockade by pirenzepine.
Topics: Anesthesia; Animals; Blood Pressure; Heart; Heart Rate; In Vitro Techniques; Male; Parasympathomimetics; Pirenzepine; Quinuclidines; Rats; Rats, Inbred Strains; Sympathomimetics; Thiophenes | 1990 |
Beneficial effects of FKS-508 (AF102B), a selective M1 agonist, on the impaired working memory in AF64A-treated rats.
Topics: Animals; Aziridines; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Hippocampus; Learning; Male; Memory; Neuromuscular Blocking Agents; Oxotremorine; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes | 1989 |
Differential effects of M1- and M2-muscarinic drugs on striatal dopamine release and metabolism in freely moving rats.
Topics: Animals; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Male; Oxotremorine; Pirenzepine; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes | 1989 |
(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3') quinuclidine (AF102B): a new M1 agonist attenuates cognitive dysfunctions in AF64A-treated rats.
Topics: Alzheimer Disease; Animals; Aziridines; Behavior, Animal; Choline; Cognition Disorders; Disease Models, Animal; Drug Design; Male; Molecular Structure; Parasympathomimetics; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Thiophenes | 1989 |
Heterogeneity of muscarinic autoreceptors and heteroreceptors in the rat brain: effects of a novel M1 agonist, AF102B.
Topics: Acetylcholine; Animals; Brain Chemistry; Corpus Striatum; Dopamine; Hippocampus; In Vitro Techniques; Male; Oxotremorine; Parasympathomimetics; Pirenzepine; Potassium; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Synaptosomes; Thiophenes | 1988 |
Amelioration of experimental amnesia (passive avoidance failure) in rodents by the selective M1 agonist AF102B.
Topics: Amnesia; Animals; Arecoline; Aziridines; Choline; Male; Memory; Mice; Mice, Inbred Strains; Oxotremorine; Parasympathomimetics; Quinuclidines; Retention, Psychology; Scopolamine; Thiophenes | 1988 |
Effects of (-)-S-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane L-tartrate monohydrate (YM796), a novel muscarinic agonist, on disturbance of passive avoidance learning behavior in drug-treated and senescence-accelerated mice.
Topics: Aging; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cycloheximide; Hemicholinium 3; Mice; Mice, Mutant Strains; Muscarinic Agonists; Protein Synthesis Inhibitors; Quinuclidines; Scopolamine; Spiro Compounds; Thiophenes | 1995 |
Sialogogic activities of SNI-2011 compared with those of pilocarpine and McN-A-343 in rat salivary glands: identification of a potential therapeutic agent for treatment of Sjörgen's syndrome.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Adrenergic Antagonists; Animals; Cholinergic Antagonists; Male; Pilocarpine; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Salivary Glands; Salivation; Sjogren's Syndrome; Thiophenes | 1994 |
NGF promotes amyloid precursor protein secretion via muscarinic receptor activation.
Topics: Amyloid beta-Protein Precursor; Animals; Carbachol; Cell Differentiation; Cell Membrane; Dose-Response Relationship, Drug; Kinetics; Nerve Growth Factors; Parasympathomimetics; PC12 Cells; Quinuclidines; Rats; Receptors, Muscarinic; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiophenes; Time Factors; Transfection | 1995 |
Effect of YM796, a novel muscarinic agonist, on the impairment of passive avoidance response in senescence-accelerated mice.
Topics: Aging; Aminoquinolines; Amitriptyline; Animals; Avoidance Learning; Cholinesterase Inhibitors; Mice; Mice, Inbred Strains; Muscarinic Agonists; Psychotropic Drugs; Quinuclidines; Spiro Compounds; Thiophenes | 1995 |
NGF-dependent neurotrophic-like effects of AF102B, an M1 muscarinic agonist, in PC12M1 cells.
Topics: Animals; Atropine; Carbachol; Cyclic AMP; Nerve Growth Factors; Parasympathomimetics; PC12 Cells; Quinuclidines; Rats; Thiophenes | 1995 |
Acetylcholine measurement of cerebrospinal fluid by in vivo microdialysis in freely moving rats.
Topics: Acetylcholine; Animals; Choline; Cholinesterase Inhibitors; Male; Microdialysis; Muscarinic Agonists; Parasympathomimetics; Quinuclidines; Rats; Rats, Wistar; Thiophenes | 1994 |
A comparison of the effects of the novel muscarinic receptor agonists L-689,660 and AF102B in tests of reference and working memory.
Topics: Animals; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Drinking Behavior; Male; Memory; Memory, Short-Term; Mice; Mice, Inbred Strains; Muscarinic Agonists; Pain Measurement; Parasympathomimetics; Pyrazines; Quinuclidines; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Scopolamine; Thiophenes | 1994 |
Opposite modulation by muscarinic M1 and M3 receptors of acetylcholine release from guinea pig ileum as measured directly.
Topics: Acetylcholine; Analysis of Variance; Animals; Bethanechol; Bethanechol Compounds; Chromatography, High Pressure Liquid; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth; Parasympatholytics; Parasympathomimetics; Piperidines; Quinuclidines; Receptors, Muscarinic; Thiophenes | 1993 |
Blockade of hippocampal M1 muscarinic receptors impairs working memory performance of rats.
Topics: Animals; Conditioning, Operant; Diamines; Dose-Response Relationship, Drug; Hippocampus; Injections; Male; Memory, Short-Term; Muscarinic Agonists; Muscarinic Antagonists; Parasympatholytics; Parasympathomimetics; Pirenzepine; Psychomotor Performance; Quinuclidines; Rats; Rats, Wistar; Thiophenes | 1994 |
Amyloid precursor protein secretion via muscarinic receptors: reduced desensitization using the M1-selective agonist AF102B.
Topics: Amyloid beta-Protein Precursor; Animals; Carbachol; Kinetics; Parasympatholytics; PC12 Cells; Quinuclidines; Receptors, Muscarinic; Recombinant Proteins; Thiophenes; Transfection | 1994 |
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.
Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1993 |
Discrete activation of transduction pathways associated with acetylcholine m1 receptor by several muscarinic ligands.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Calcium; Carbachol; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; GTP-Binding Proteins; Hydrolysis; Phosphatidylinositols; Pilocarpine; Protein Binding; Quinuclidines; Receptors, Cholinergic; Signal Transduction; Thiophenes; Transfection | 1994 |
[Effect of a muscarinic (M1) receptor agonist on sympathetic nerve activity in rats].
Topics: Adrenal Medulla; Animals; Blood Pressure; Dose-Response Relationship, Drug; Electrophysiology; Heart; Heart Rate; Male; Parasympathomimetics; Pirenzepine; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Sympathetic Nervous System; Thiophenes | 1993 |
Activation of m1 muscarinic acetylcholine receptor regulates tau phosphorylation in transfected PC12 cells.
Topics: Animals; Carbachol; Dose-Response Relationship, Drug; Drug Synergism; Muscarinic Agonists; Nerve Growth Factors; Neurons; PC12 Cells; Phosphorylation; Quinuclidines; Rats; Receptors, Muscarinic; tau Proteins; Thiophenes; Time Factors; Transfection | 1996 |
Modulation of rhythmical slow activity, long-term potentiation and memory by muscarinic receptor agonists.
Topics: Administration, Oral; Animals; Avoidance Learning; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Hippocampus; Long-Term Potentiation; Male; Memory; Mice; Mice, Inbred Strains; Muscarinic Agonists; Oxotremorine; Quinuclidines; Rats; Rats, Wistar; Scopolamine; Synaptic Transmission; Theta Rhythm; Thiophenes | 1996 |
[Functional role of muscarinic M1 receptor for the ganglionic transmission in the rat superior cervical ganglion].
Topics: Animals; Dimethylphenylpiperazinium Iodide; Ganglionic Stimulants; Hexamethonium; Laser-Doppler Flowmetry; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Parasympathomimetics; Pirenzepine; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Nicotinic; Superior Cervical Ganglion; Synaptic Transmission; Thiophenes; Thyroid Gland | 1997 |
Long-lasting salivation induced by a novel muscarinic receptor agonist SNI-2011 in rats and dogs.
Topics: Animals; Dogs; Female; Male; Muscarinic Agonists; Pilocarpine; Quinuclidines; Rats; Rats, Wistar; Salivation; Secretory Rate; Thiophenes; Time Factors | 1997 |
Effects of AF102B and tacrine on delayed match-to-sample in monkeys.
Topics: Age Factors; Animals; Humans; Macaca radiata; Memory; Memory Disorders; Parasympathomimetics; Quinuclidines; Reaction Time; Tacrine; Thiophenes | 1998 |
(+/-)-cis-2-methylspiro[1,3-oxathiolane-5,3'-quinuclidine] hydrochloride, hemihydrate (SNI-2011, cevimeline hydrochloride) induces saliva and tear secretions in rats and mice: the role of muscarinic acetylcholine receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred ICR; Muscarinic Agonists; Parasympathomimetics; Quinuclidines; Quinuclidinyl Benzilate; Rats; Rats, Wistar; Receptors, Muscarinic; Saliva; Salivary Glands; Tears; Thiophenes; Time Factors; Tritium | 1998 |
Reduction of motoric agitation and restlessness by AF102B and tacrine in the macaque.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Macaca radiata; Male; Motor Activity; Muscarinic Agonists; Pilot Projects; Psychomotor Agitation; Quinuclidines; Tacrine; Thiophenes | 1999 |
Divided attention-enhancing effects of AF102B and THA in aging monkeys.
Topics: Aging; Animals; Attention; Cholinergic Agents; Cholinesterase Inhibitors; Female; Macaca radiata; Male; Muscarinic Agonists; Psychomotor Performance; Quinuclidines; Tacrine; Thiophenes | 1999 |
Persistent increase in the amount of aquaporin-5 in the apical plasma membrane of rat parotid acinar cells induced by a muscarinic agonist SNI-2011.
Topics: Animals; Aquaporin 5; Aquaporins; Atropine; Calcium; Cell Membrane; Cells, Cultured; Inositol 1,4,5-Trisphosphate; Male; Membrane Proteins; Muscarinic Agonists; Parotid Gland; Piperidines; Quinuclidines; Rats; Rats, Wistar; Thiophenes | 2000 |
Pro-cognitive activity induced in the rat by low doses of R-(+)-hyoscyamine.
Topics: Amnesia; Animals; Atropine; Avoidance Learning; Dose-Response Relationship, Drug; Injections, Intraventricular; Isomerism; Learning; Memory; Motor Activity; Muscarinic Agonists; Physostigmine; Phytotherapy; Plants, Medicinal; Quinuclidines; Rats; Rats, Wistar; Thiophenes | 2000 |
Cevimeline (Evoxac) for dry mouth.
Topics: Acetylcholine; Clinical Trials as Topic; Contraindications; Humans; Intestinal Absorption; Muscarinic Agonists; Nausea; Pilocarpine; Quinuclidines; Thiophenes; Xerostomia | 2000 |
The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Female; Humans; Male; Quinuclidines; Thiophenes | 2000 |
A new medication for treatment of dry mouth in Sjögren's syndrome.
Topics: Contraindications; Humans; Muscarinic Agonists; Pilocarpine; Quinuclidines; Receptors, Muscarinic; Salivary Glands; Salivation; Sjogren's Syndrome; Thiophenes; Xerostomia | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
Salivary enhancement: current status and future therapies.
Topics: Animals; Aquaporin 1; Aquaporins; Blood Group Antigens; Cholinergic Agents; Cranial Irradiation; Dental Caries; Genetic Therapy; Humans; Parasympathomimetics; Pilocarpine; Quinuclidines; Salivary Glands; Sjogren's Syndrome; Thiophenes; Xerostomia | 2001 |
Identification of human drug-metabolizing enzymes involved in the metabolism of SNI-2011.
Topics: Animals; Cytochrome P-450 Enzyme System; DNA, Complementary; Enzyme Inhibitors; Humans; Insecta; Isoenzymes; Kidney; Microsomes; Microsomes, Liver; Muscarinic Agonists; Oxygenases; Quinuclidines; Thiophenes | 2001 |
General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 1st communication: effects on general behavior and central nervous system.
Topics: Anesthetics, Intravenous; Animals; Anticonvulsants; Behavior, Animal; Body Temperature; Cats; Central Nervous System; Electroencephalography; Electroshock; Female; Male; Mice; Mice, Inbred ICR; Motor Activity; Muscarinic Agonists; Pain Measurement; Psychomotor Performance; Quinuclidines; Rats; Rats, Wistar; Reflex; Sjogren's Syndrome; Thiopental; Thiophenes; Xerostomia | 2002 |
General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 2nd communication: effects on somatic nervous system and on autonomic nervous system and smooth muscle.
Topics: Anesthetics; Animals; Autonomic Nervous System; Catecholamines; Cats; Guinea Pigs; Histamine Antagonists; Male; Mice; Mice, Inbred ICR; Muscarinic Agonists; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Muscle, Smooth, Vascular; Neuromuscular Junction; Nictitating Membrane; Peripheral Nervous System; Pupil; Quinuclidines; Rabbits; Rats; Rats, Inbred F344; Rats, Wistar; Sjogren's Syndrome; Thiophenes; Xerostomia | 2002 |
General pharmacological profile of the novel muscarinic receptor agonist SNI-2011, a drug for xerostomia in Sjögren's syndrome. 3rd communication: effects on respiratory and cardiovascular systems.
Topics: Animals; Atropine; Dogs; Electrocardiography; Guinea Pigs; Heart Atria; Hemodynamics; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Myocardial Contraction; Quinuclidines; Regional Blood Flow; Respiratory Mechanics; Sjogren's Syndrome; Thiophenes; Xerostomia | 2002 |
Assessing salivary gland hypofunction--Part two.
Topics: Anti-Infective Agents, Local; Candidiasis, Oral; Dental Caries; Humans; Maltose; Mastication; Muscarinic Agonists; Pilocarpine; Quinuclidines; Saliva; Thiophenes; Xerostomia | 2002 |
Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs.
Topics: Animals; Area Under Curve; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dogs; Enzyme Inhibitors; Female; Hydrogen-Ion Concentration; Injections, Intravenous; Intestinal Absorption; Male; Microsomes, Liver; Muscarinic Agonists; Quinuclidines; Rats; Rats, Wistar; Salivation; Thiophenes; Tissue Distribution | 2003 |
Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases | 2003 |
Age-related decreases in the response of aquaporin-5 to acetylcholine in rat parotid glands.
Topics: Acetylcholine; Adrenergic Agonists; Aging; Animals; Aquaporin 5; Aquaporins; Cell Membrane; Cholinergic Agents; Epinephrine; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Male; Membrane Proteins; Muscarinic Agonists; Nitric Oxide Synthase; Parotid Gland; Quinuclidines; Rats; Rats, Wistar; Receptor, Muscarinic M3; Receptors, Muscarinic; Thiophenes | 2003 |
Effects of pilocarpine hydrochloride and cevimeline on submandibular/sublingual salivation in rat xerostomia model produced by X-ray irradiation.
Topics: Animals; Antipsychotic Agents; Body Temperature; Cardiovascular System; Central Nervous System; Chlorpromazine; Dose-Response Relationship, Drug; Male; Muscarinic Agonists; Pilocarpine; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic; Respiratory System; Salivary Proteins and Peptides; Salivation; Submandibular Gland; Thiophenes; Xerostomia | 2003 |
Reduction in distractibility with AF102B and THA in the macaque.
Topics: Animals; Attention; Cholinesterase Inhibitors; Conditioning, Operant; Female; Macaca radiata; Male; Muscarinic Agonists; Nootropic Agents; Psychomotor Performance; Quinuclidines; Space Perception; Tacrine; Thiophenes; Visual Perception | 2003 |
Ligand-selective signaling and high-content screening for GPCR drugs.
Topics: Drug Design; Drug Evaluation, Preclinical; Humans; Ligands; Molecular Conformation; Quinuclidines; Receptor, Muscarinic M1; Receptors, G-Protein-Coupled; Signal Transduction; Thiophenes | 2003 |
Cevimeline gargle for the treatment of xerostomia in patients with Sjögren's syndrome.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Male; Middle Aged; Mouthwashes; Parasympathomimetics; Quinuclidines; Sjogren's Syndrome; Thiophenes; Xerostomia | 2004 |
[The effectiveness of cevimeline hydrochloride on dry cough in Sjögren's syndrome].
Topics: Adult; Aged; Cough; Dry Eye Syndromes; Female; Humans; Male; Middle Aged; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Thiophenes | 2004 |
[Future therapy strategies for salivary gland impairment].
Topics: Amifostine; Cranial Irradiation; Head and Neck Neoplasms; Humans; Muscarinic Agonists; Pilocarpine; Quinuclidines; Radiation Injuries; Radiation-Protective Agents; Regeneration; Saliva; Salivary Glands; Thiophenes | 2004 |
[Clinical significance of cevimeline hydrochloride in the treatment of dry mouth in patients with Sjögren's syndrome].
Topics: Female; Humans; Middle Aged; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Thiophenes; Xerostomia | 2004 |
Dentistry. Implications and management of xerostomia in the HIV patient.
Topics: Antiretroviral Therapy, Highly Active; Cholinergic Agents; HIV Infections; HIV Protease Inhibitors; Humans; Pilocarpine; Quinuclidines; Reverse Transcriptase Inhibitors; Thiophenes; Xerostomia | 2005 |
Cevimeline hydrochloride improved cholinergic dysfunction in a patient with pure autonomic failure.
Topics: Acetylcholine; Autonomic Nervous System Diseases; Humans; Male; Middle Aged; Muscarinic Agonists; Quinuclidines; Thiophenes | 2006 |
Idiopathic CD4+ lymphocytopenia and Sjogren syndrome.
Topics: CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Female; Humans; Middle Aged; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; T-Lymphocytopenia, Idiopathic CD4-Positive; Thiophenes | 2005 |
Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland.
Topics: Animals; Aquaporin 5; Aquaporins; Calcium; Enzyme Activation; G-Protein-Coupled Receptor Kinase 2; Male; Membrane Microdomains; Membrane Proteins; Parotid Gland; Protein Transport; Quinuclidines; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Thiophenes | 2005 |
Dentistry. Clinic assesses effect of medication on dry mouth syndrome.
Topics: Dental Health Services; Female; HIV Infections; Humans; Male; Quinuclidines; Thiophenes; Xerostomia | 2005 |
New approaches to preventing xerostomia.
Topics: Amifostine; Cytoprotection; Humans; Muscarinic Agonists; Neoplasms; Pilocarpine; Quinuclidines; Radiation Injuries; Radiation-Protective Agents; Radiotherapy Dosage; Radiotherapy, Intensity-Modulated; Salivary Glands; Thiophenes; Xerostomia | 2006 |
Cevimeline reduced mouth dryness and increased salivary flow in patients with xerostomia complicating chronic graft-versus-host disease.
Topics: Adult; Graft vs Host Disease; Humans; Male; Middle Aged; Parasympathomimetics; Quinuclidines; Thiophenes; Xerostomia | 2006 |
Effects of cevimeline on salivation and thirst in conscious rats.
Topics: Animals; Central Nervous System; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Parotid Gland; Quinuclidines; Rats; Rats, Wistar; Salivation; Thiophenes; Thirst | 2007 |
[Revision of the recommendations of the Commission on Pharmacotherapy of the German Society for Rheumatology. Recommendations for supportive therapy for Sjögren's syndrome].
Topics: Bromhexine; Cyclosporine; Dry Eye Syndromes; Electric Stimulation Therapy; Expectorants; Humans; Muscarinic Antagonists; Ophthalmic Solutions; Pilocarpine; Quinuclidines; Sjogren's Syndrome; Thiophenes; Xerostomia | 2007 |
Open-label, long-term safety study of cevimeline in the treatment of postirradiation xerostomia.
Topics: Adult; Aged; Aged, 80 and over; Diarrhea; Dyspepsia; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Muscarinic Agonists; Nausea; Quinuclidines; Radiotherapy Dosage; Sweat; Thiophenes; Xerostomia | 2007 |
Effect of a muscarinic M3 receptor agonist on gastric motility.
Topics: Administration, Oral; Adult; Aged, 80 and over; Drug Administration Schedule; Dyspepsia; Female; Gastrointestinal Agents; Gastrointestinal Motility; Humans; Muscarinic Agonists; Proton Pump Inhibitors; Quinuclidines; Receptor, Muscarinic M3; Thiophenes; Treatment Outcome | 2007 |
Effect of cevimeline on radiation-induced salivary gland dysfunction and AQP5 in submandibular gland in mice.
Topics: Animals; Aquaporin 5; Disease Models, Animal; Female; Fluorescent Antibody Technique; Mice; Mice, Inbred ICR; Muscarinic Agonists; Quinuclidines; Radiation Dosage; Reverse Transcriptase Polymerase Chain Reaction; Saliva; Secretory Rate; Submandibular Gland; Submandibular Gland Diseases; Thiophenes; Time Factors; X-Rays; Xerostomia | 2007 |
Degradation of submandibular gland AQP5 by parasympathetic denervation of chorda tympani and its recovery by cevimeline, an M3 muscarinic receptor agonist.
Topics: Animals; Aquaporin 1; Aquaporin 5; Chorda Tympani Nerve; Gene Expression Regulation; Lysosomes; Male; Muscarinic Agonists; Parasympathectomy; Pilocarpine; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Submandibular Gland; Sympathectomy; Thiophenes; Time Factors | 2008 |
Cevimeline.
Topics: Animals; Area Under Curve; Diarrhea; Female; Half-Life; Humans; Molecular Structure; Muscarinic Agonists; Nausea; Quinuclidines; Randomized Controlled Trials as Topic; Rhinitis; Sjogren's Syndrome; Sweating; Thiophenes; Treatment Outcome | 2008 |
Identification of aquaporin-5 and lipid rafts in human resting saliva and their release into cevimeline-stimulated saliva.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Amylases; Animals; Aquaporin 5; Circadian Rhythm; Female; Fluorescent Antibody Technique; Humans; Male; Membrane Microdomains; Microscopy, Confocal; Middle Aged; Parotid Gland; Quinuclidines; Rats; Rats, Wistar; Receptor, Muscarinic M3; Saliva; Salivary Glands; Sleep; Thiophenes; Wakefulness; Young Adult | 2009 |
Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment.
Topics: Bodily Secretions; Diagnosis, Differential; Drug Resistance; Humans; Hypergammaglobulinemia; Middle Aged; Muscarinic Agonists; Quinuclidines; Saliva; Sjogren's Syndrome; Thiophenes; Xerostomia | 2009 |
Dosage form design and in vitro/in vivo evaluation of cevimeline extended-release tablet formulations.
Topics: Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dogs; Dosage Forms; Drug Design; Drug Evaluation, Preclinical; Male; Quinuclidines; Tablets; Tablets, Enteric-Coated; Thiophenes | 2010 |
An alpha7 nicotinic acetylcholine receptor-selective agonist reduces weight gain and metabolic changes in a mouse model of diabetes.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Binding, Competitive; Blood Glucose; Cell Line; Cloning, Molecular; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Electrophysiological Phenomena; Energy Metabolism; Female; Humans; Ligands; Lipid Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; Nicotinic Agonists; Obesity; Oocytes; Patch-Clamp Techniques; Quinuclidines; Rats; Receptors, Leptin; Receptors, Nicotinic; Thiophenes; Tumor Necrosis Factor-alpha; Weight Gain; Xenopus laevis | 2010 |
Cevimeline enhances the excitability of rat superior salivatory neurons.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Medulla Oblongata; Models, Animal; Muscarinic Agonists; Neurons; Patch-Clamp Techniques; Quinuclidines; Rats; Rats, Wistar; Receptors, Muscarinic; Salivation; Submandibular Gland; Thiophenes | 2009 |
Correlation between salivary secretion and salivary AQP5 levels in health and disease.
Topics: Aquaporin 5; Diabetes Mellitus, Type 1; Humans; Membrane Microdomains; Muscarinic Agonists; Quinuclidines; Receptor, Muscarinic M3; Saliva; Salivary Glands; Salivation; Sjogren's Syndrome; Thiophenes | 2009 |
Effects of pilocarpine and cevimeline on Ca2+ mobilization in rat parotid acini and ducts.
Topics: Animals; Calcium; Calcium Signaling; Muscarinic Agonists; Muscarinic Antagonists; Parotid Gland; Pilocarpine; Piperidines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 2009 |
Effects of cevimeline on the immunolocalization of aquaporin-5 and the ultrastructure of salivary glands in Sjögren's syndrome model mice.
Topics: Animals; Aquaporin 5; Disease Models, Animal; Female; Immunohistochemistry; Mice; Mice, Inbred BALB C; Mice, Inbred MRL lpr; Microscopy, Electron; Muscarinic Agonists; Quinuclidines; Sjogren's Syndrome; Submandibular Gland; Thiophenes | 2009 |
New epitopes and function of anti-M3 muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome.
Topics: Adult; Aged; Amino Acid Sequence; Antibodies, Anti-Idiotypic; Calcium; Cells, Cultured; Epitopes; Epitopes, B-Lymphocyte; Female; Fluorescent Antibody Technique; Gene Expression; Humans; Intracellular Space; Male; Middle Aged; Molecular Sequence Data; Muscarinic Agonists; Peptides; Quinuclidines; Receptor, Muscarinic M3; Reverse Transcriptase Polymerase Chain Reaction; Salivary Glands; Sjogren's Syndrome; Thiophenes | 2010 |
Cevimeline (Evoxac ®) overdose.
Topics: Drug Overdose; Female; Humans; Middle Aged; Muscarinic Agonists; Poisoning; Quinuclidines; Thiophenes; Treatment Outcome | 2011 |
The relationship between the drug concentration profiles in plasma and the drug doses in the colon.
Topics: Administration, Oral; Animals; Anti-Allergic Agents; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Area Under Curve; Biological Availability; Colon; Delayed-Action Preparations; Diclofenac; Diltiazem; Dogs; Dose-Response Relationship, Drug; Hypoglycemic Agents; Metformin; Muscarinic Agonists; Quinuclidines; Terfenadine; Thiophenes; Verapamil | 2010 |
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
Topics: Animals; Atropine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Ileum; Lower Gastrointestinal Tract; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Oligopeptides; Piperidines; Piroxicam; Prostaglandins; Quinuclidines; Tetrodotoxin; Thiophenes; Upper Gastrointestinal Tract | 2011 |
Cevimeline-induced monophasic salivation from the mouse submandibular gland: decreased Na+ content in saliva results from specific and early activation of Na+/H+ exchange.
Topics: Animals; Mice; Mice, Inbred C57BL; Quinuclidines; Saliva; Salivation; Sodium; Sodium-Hydrogen Exchangers; Submandibular Gland; Thiophenes | 2011 |
Abnormal subcellular localization of AQP5 and downregulated AQP5 protein in parotid glands of streptozotocin-induced diabetic rats.
Topics: Animals; Aquaporin 5; Blotting, Western; Cell Membrane; Cyclic GMP; Cytoplasm; Diabetes Mellitus, Experimental; Down-Regulation; Hypoglycemic Agents; Immunohistochemistry; Insulin; Male; Membrane Proteins; Muscarinic Agonists; Nitric Oxide; Parotid Gland; Protein Transport; Quinuclidines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes; Time Factors; Xerostomia | 2011 |
EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Partial Agonism; Indans; Male; Memory; Nicotinic Agonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic; Thiophenes | 2012 |
Distinct effects of cevimeline and pilocarpine on salivary mechanisms, cardiovascular response and thirst sensation in rats.
Topics: Analysis of Variance; Animals; Cardiovascular System; Drinking; Muscarinic Agonists; Parotid Gland; Pilocarpine; Quinuclidines; Rats; Rats, Wistar; Salivation; Sensitivity and Specificity; Subfornical Organ; Thiophenes; Thirst | 2012 |
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Checkpoint Kinase 1; DNA Damage; Drug Resistance; Fibroblasts; Foreskin; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Male; Mice; Protein Kinases; Quinolines; Quinuclidines; RNA Interference; Spleen; Staurosporine; Thiophenes; Urea; Vorinostat | 2011 |
α7 neuronal nicotinic receptor agonist (TC-7020) reverses increased striatal dopamine release during acoustic PPI testing in a transgenic mouse model of schizophrenia.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acoustic Stimulation; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Homovanillic Acid; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microdialysis; Neural Inhibition; Nicotinic Agonists; Quinuclidines; Receptor, Fibroblast Growth Factor, Type 1; Reflex, Startle; Schizophrenia; Sensory Gating; Thiophenes | 2012 |
Pharmacogenomic biomarkers in dermatologic drugs.
Topics: Androstenes; Aryl Hydrocarbon Hydroxylases; Biomarkers; Chloroquine; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Dapsone; Dermatologic Agents; Dihydropyrimidine Dehydrogenase Deficiency; Ethinyl Estradiol; Fluorouracil; Glucosephosphate Dehydrogenase Deficiency; Humans; Naphthalenes; Primaquine; Quinuclidines; Terbinafine; Thiophenes | 2013 |
Using cholinergic M1 receptor positive allosteric modulators to improve memory via enhancement of brain cholinergic communication.
Topics: Animals; Behavior, Animal; Brain; Calcium; Carboxylic Acids; CHO Cells; Cholinergic Fibers; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Maze Learning; Memory; Microdialysis; Motor Activity; Muscarinic Agonists; Muscarinic Antagonists; Nootropic Agents; Quinolones; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Salivation; Scopolamine; Thiophenes; Transfection | 2012 |
Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Ganglia, Spinal; Male; Neuralgia; Nicotinic Agonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Thiophenes | 2012 |
An immunohistochemistry-based study on aquaporin (AQP)-1, 3, 4, 5 and 8 in the parotid glands, submandibular glands and sublingual glands of Sjögren's syndrome mouse models chronically administered cevimeline.
Topics: Animals; Aquaporin 1; Aquaporin 3; Aquaporin 4; Aquaporin 5; Aquaporins; Disease Models, Animal; Immunohistochemistry; Mice; Muscarinic Agonists; Parotid Gland; Quinuclidines; Salivation; Sjogren's Syndrome; Sublingual Gland; Submandibular Gland; Thiophenes; Time Factors | 2013 |
Activation of developmental nuclear fibroblast growth factor receptor 1 signaling and neurogenesis in adult brain by α7 nicotinic receptor agonist.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Blotting, Western; Brain; Cell Proliferation; Chromatin Immunoprecipitation; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurogenesis; Nicotinic Agonists; Quinuclidines; Real-Time Polymerase Chain Reaction; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Nicotinic; Signal Transduction; Thiophenes | 2013 |
The role of proof of concept (POC) studies in drug development using the EVP-6124 POC study as an example.
Topics: Clinical Trials as Topic; Drug Discovery; Humans; Quinuclidines; Thiophenes | 2014 |
The novel α7 nicotinic acetylcholine receptor agonist EVP-6124 enhances dopamine, acetylcholine, and glutamate efflux in rat cortex and nucleus accumbens.
Topics: Acetylcholine; Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Animals; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Nicotinic Agonists; Nicotinic Antagonists; Nucleus Accumbens; Prefrontal Cortex; Quinuclidines; Rats; Rats, Sprague-Dawley; Thiophenes | 2014 |
PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzofurans; Disease Models, Animal; Excitatory Amino Acid Antagonists; Hyperkinesis; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Quinuclidines; Rotarod Performance Test; Schizophrenia; Schizophrenic Psychology; Social Behavior; Thiophenes | 2014 |
Understanding the role α7 nicotinic receptors play in dopamine efflux in nucleus accumbens.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cerebral Cortex; Cholinergic Agents; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Isoxazoles; Male; Models, Neurological; Neural Pathways; Neurons; Nucleus Accumbens; Phenylurea Compounds; Quinuclidines; Rats, Sprague-Dawley; Synapses; Thiophenes | 2014 |
Tropisetron and its targets in Alzheimer's disease.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Humans; Indoles; Inflammation; Nicotinic Agonists; Quinuclidines; Serotonin Antagonists; Thiophenes; Tropisetron | 2015 |
Continuous infusion of the α7 nicotinic acetylcholine receptor agonist EVP-6124 produces no signs of tolerance at memory-enhancing doses in rats: a pharmacokinetic and behavioral study.
Topics: Administration, Oral; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood Chemical Analysis; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Tolerance; Male; Models, Animal; Nicotinic Agonists; Nootropic Agents; Pilot Projects; Quinuclidines; Rats, Wistar; Recognition, Psychology; Thiophenes | 2015 |
Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.
Topics: Animals; Antihypertensive Agents; Carbon Disulfide; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Disease Models, Animal; Glaucoma; Humans; Intraocular Pressure; Male; Molecular Docking Simulation; Morpholines; Piperazines; Piperidines; Quinuclidines; Rabbits; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Thiocarbamates; Thiophenes | 2015 |
Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch-16.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Automation; Bridged Bicyclo Compounds; Humans; Indazoles; Isoxazoles; Nicotinic Agonists; Patch-Clamp Techniques; Phenylurea Compounds; Quinuclidines; Rats; Thiophenes; Tumor Cells, Cultured | 2015 |
Acute Effects of Muscarinic M1 Receptor Modulation on AβPP Metabolism and Amyloid-β Levels in vivo: A Microdialysis Study.
Topics: Actins; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Dicyclomine; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Hippocampus; Mice; Mice, Transgenic; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Quinuclidines; Receptor, Muscarinic M1; Statistics, Nonparametric; Thiophenes | 2015 |
Concentration-response relationship of the α7 nicotinic acetylcholine receptor agonist FRM-17874 across multiple in vitro and in vivo assays.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Hippocampus; Humans; Learning; Male; Memory; Mice; Mice, Inbred C57BL; Oocytes; Protein Binding; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Thiophenes; Xenopus laevis | 2015 |
Hydrogen sulfide: a novel gaseous signaling molecule and intracellular Ca2+ regulator in rat parotid acinar cells.
Topics: Acinar Cells; Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Hydrogen Sulfide; Inositol 1,4,5-Trisphosphate Receptors; Male; Muscarinic Agonists; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Parotid Gland; Phosphoinositide-3 Kinase Inhibitors; Quinuclidines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; Ryanodine Receptor Calcium Release Channel; Soluble Guanylyl Cyclase; Taurine; Thiophenes; Type C Phospholipases | 2015 |
Salivary gland ultrasonography as a primary imaging tool for predicting efficacy of xerostomia treatment in patients with Sjögren's syndrome.
Topics: Administration, Oral; Aged; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Middle Aged; Muscarinic Agonists; Parasympathomimetics; Pilocarpine; Prednisolone; Prognosis; Quinuclidines; Retrospective Studies; Salivary Glands; Severity of Illness Index; Sjogren's Syndrome; Therapeutic Irrigation; Thiophenes; Treatment Outcome; Ultrasonography; Xerostomia | 2016 |
Encenicline, an α7 Nicotinic Acetylcholine Receptor Partial Agonist, Reduces Immune Cell Infiltration in the Colon and Improves Experimental Colitis in Mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Flow Cytometry; Forkhead Transcription Factors; Hexamethonium; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Nicotinic Agonists; Nicotinic Antagonists; Peroxidase; Quinuclidines; T-Lymphocytes; Thiophenes; Trinitrobenzenesulfonic Acid | 2016 |
Structural characterization of cevimeline and its trans-impurity by single crystal XRD.
Topics: Crystallography, X-Ray; Drug Contamination; Muscarinic Agonists; Quinuclidines; Stereoisomerism; Thiophenes; X-Ray Diffraction | 2016 |
Selective activation of α7 nicotinic acetylcholine receptors augments hippocampal oscillations.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzamides; Bridged Bicyclo Compounds; Hippocampus; Male; Mice; Mice, Knockout; Nicotinic Agonists; Protein Binding; Quinuclidines; Theta Rhythm; Thiophenes | 2016 |
Hippocampal network dynamics in response to α7 nACh receptors activation in amyloid-β overproducing transgenic mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cognition; Female; Gamma Rhythm; Hippocampus; Male; Mice, Transgenic; Molecular Targeted Therapy; Nerve Net; Quinuclidines; Theta Rhythm; Thiophenes | 2016 |
α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Donepezil; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; GABA Agents; GABAergic Neurons; Hippocampus; Humans; Indans; Inhibitory Postsynaptic Potentials; Male; Nerve Net; Nicotinic Agonists; Oocytes; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Thiophenes; Xenopus laevis | 2016 |
Activation of α7 nicotinic acetylcholine receptors facilitates long-term potentiation at the hippocampal-prefrontal cortex synapses in vivo.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; CA1 Region, Hippocampal; Cognition; Dose-Response Relationship, Drug; Electric Stimulation; Hippocampus; Long-Term Potentiation; Male; Nicotinic Agonists; Prefrontal Cortex; Quinuclidines; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Thiophenes | 2016 |
Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Behavior, Animal; Chromatography, High Pressure Liquid; Conditioning, Psychological; Electroencephalography; Electromyography; Excitatory Postsynaptic Potentials; Fear; Hippocampus; Immunohistochemistry; Learning; Memory; Mice; Mice, Transgenic; Microdialysis; Neck Muscles; Nicotinic Agonists; Optical Imaging; Optogenetics; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Synapses; Thiophenes; Wakefulness | 2017 |
Effects of cevimeline on excitability of parasympathetic preganglionic neurons in the superior salivatory nucleus of rats.
Topics: Animals; Animals, Newborn; Dose-Response Relationship, Drug; Immunohistochemistry; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Neuroanatomical Tract-Tracing Techniques; Neurons; Parasympathetic Nervous System; Parasympathomimetics; Patch-Clamp Techniques; Quinuclidines; Rats, Wistar; Receptors, Muscarinic; Salivary Glands; Thiophenes; Tissue Culture Techniques | 2017 |
Long-term Use of the Sialogogue Medications Pilocarpine and Cevimeline Can Reduce Xerostomia Symptoms and Increase Salivary Flow in Head and Neck Cancer Survivors After Radiotherapy.
Topics: Head and Neck Neoplasms; Humans; Pilocarpine; Quinuclidines; Survivors; Thiophenes; Xerostomia | 2017 |
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Donepezil; Indans; Macaca fascicularis; Male; Paired-Associate Learning; Piperidines; Quinuclidines; Reaction Time; Scopolamine; Space Perception; Spiro Compounds; Task Performance and Analysis; Thiophenes; Treatment Outcome; Visual Perception | 2017 |
Risk of Parkinson disease in Sjögren syndrome administered ineffective immunosuppressant therapies: A nationwide population-based study.
Topics: Adult; Aged; Anti-Inflammatory Agents; Antirheumatic Agents; Comorbidity; Female; Humans; Hydroxychloroquine; Immunosuppression Therapy; Incidence; Male; Methylprednisolone; Middle Aged; Muscarinic Agonists; National Health Programs; Parkinson Disease; Pilocarpine; Quinuclidines; Retrospective Studies; Risk Factors; Sjogren's Syndrome; Taiwan; Thiophenes | 2019 |
Quantitative assessment of oligomeric amyloid β peptide binding to α7 nicotinic receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Amyloid beta-Peptides; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; HEK293 Cells; Humans; Isoxazoles; Ligands; Phenylurea Compounds; Pyridines; Pyridinium Compounds; Quinuclidines; Thiophenes | 2019 |
Comparing the effectiveness and adverse effects of pilocarpine and cevimeline in patients with hyposalivation.
Topics: Adult; Aged; Female; Follow-Up Studies; Humans; Middle Aged; Muscarinic Agonists; Pilocarpine; Quinuclidines; Retrospective Studies; Thiophenes; Time Factors; Xerostomia | 2019 |
Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Cycle Proteins; Cell Line, Tumor; Drug Design; Drug Discovery; Formaldehyde; Humans; Mice; Molecular Docking Simulation; Molecular Structure; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrazolones; Pyrimidines; Pyrimidinones; Quinuclidines; Structure-Activity Relationship; Thiophenes; Xenograft Model Antitumor Assays | 2020 |
The dosage-dependent effects of cevimeline in preventing olanzapine-induced metabolic side-effects in female rats.
Topics: Adipose Tissue; Adiposity; Animals; Behavior, Animal; Blood Glucose; Dose-Response Relationship, Drug; Drug Interactions; Eating; Female; Locomotion; Metabolic Syndrome; Olanzapine; Open Field Test; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Thiophenes; Treatment Outcome; Triglycerides; Weight Gain | 2020 |
Aged rhesus monkeys: Cognitive performance categorizations and preclinical drug testing.
Topics: Aging; Animals; Cognition; Cognitive Dysfunction; Drug Evaluation, Preclinical; Female; Macaca mulatta; Male; Memory, Short-Term; Nootropic Agents; Quinuclidines; Thiophenes | 2021 |
Reactivity of human labial glands in response to cevimeline treatment.
Topics: Carbachol; Humans; Lip; Quinuclidines; Salivary Glands; Sjogren's Syndrome; Thiophenes | 2021 |
Cevimeline-induced anti-inflammatory effect through upregulations of mucins in the ocular surface of a dry eye mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Conjunctiva; Cornea; Dry Eye Syndromes; Epithelial Cells; Female; Lacrimal Apparatus; Male; Mice; Mice, Inbred NOD; Mucins; Ophthalmic Solutions; Quinuclidines; Tears; Thiophenes; Up-Regulation | 2021 |
Cevimeline co-treatment attenuates olanzapine-induced metabolic disorders via modulating hepatic M3 muscarinic receptor: AMPKα signalling pathway in female rats.
Topics: AMP-Activated Protein Kinases; Animals; Antipsychotic Agents; Female; Liver; Metabolic Diseases; Muscarinic Agonists; Olanzapine; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Signal Transduction; Thiophenes; Weight Gain | 2022 |
Safety and efficacy of pilocarpine, cevimeline, and diquafosol compared to artificial tears for the treatment of dry eye: protocol for a systematic review.
Topics: Dry Eye Syndromes; Humans; Lubricant Eye Drops; Meta-Analysis as Topic; Pilocarpine; Polyphosphates; Quinuclidines; Secretagogues; Systematic Reviews as Topic; Thiophenes; Uracil Nucleotides | 2022 |
Suspected cholinergic toxicity due to cevimeline hydrochloride and Bacopa monnieri interaction: a case report.
Topics: Bacopa; Cholinergic Agents; Cytochrome P-450 Enzyme System; Female; Humans; Middle Aged; Quinuclidines; Sjogren's Syndrome; Thiophenes | 2022 |