quinuclidines has been researched along with substance p in 167 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 69 (41.32) | 18.2507 |
| 2000's | 77 (46.11) | 29.6817 |
| 2010's | 21 (12.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fong, TM; Huang, RR; Strader, CD | 1 |
| Bansal, A; Ber, E; Burns, D; Cascieri, MA; Fong, TM; Frances, B; Sadowski, S; Seward, E; Strader, CD; Swain, C | 1 |
| Gitter, BD; Howbert, JJ; Nixon, JA; Regoli, D; Rouissi, N; Waters, DC | 1 |
| Bruns, RF; Gitter, BD; Howbert, JJ; Mason, NR; Nixon, JA; Waters, DC | 1 |
| Gether, U; Schwartz, TW; Zoffmann, S | 1 |
| Bichon, D; Doutremepuich, JD; Ducoux, JP; Emonds-Alt, X; Heaulme, M; Neliat, G; Proietto, V; Santucci, V; Steinberg, R; Vilain, P | 1 |
| Ber, E; Cascieri, MA; Macleod, AM; Merchant, KJ; Sadowski, S; Shiao, LL; Strader, CD; Swain, CJ; Underwood, D; Yu, H | 1 |
| Fong, TM; Huang, RR; Strader, CD; Yu, H | 1 |
| Bordey, A; Emonds-Alt, X; Feltz, P; Gauthier, T; Le Fur, G; Lefevre, IA; Oury-Donat, F; Soubrie, P; Thurneyssen, O | 1 |
| Bryce, DK; Crawford, RT; Drozda, SE; Longo, KP; Lowe, JA; McLean, S; Nagahisa, A; Snider, RM; Tsuchiya, M | 1 |
| Daniel, S; Fong, TM; Longmore, J; Mazina, KE; Sirotina, A; Strader, CD; Tota, MR | 1 |
| Croci, T; Emonds-Alt, X; Le Fur, G; Manara, L | 1 |
| Bollinger, RR; Maggio, JE; Mantyh, CR; Mantyh, PW; Pappas, TN; Vigna, SR | 1 |
| Brain, SD; Hall, JM | 1 |
| Bowery, NG; Malcangio, M | 1 |
| Giuliani, S; Maggi, CA; Zagorodnyuk, V | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Meini, S | 1 |
| Martini, F; Puizillout, JJ; Reynaud, JC | 1 |
| Andersson, KE; Ishizuka, O; Mattiasson, A | 1 |
| Drozda, SE; Jackson, ER; Kanai, Y; Longo, KP; Morrone, J; Nagahisa, A; Nakagaki, M; Snider, RM; Suga, O; Zorn, SH | 1 |
| Doble, A; Heuillet, E; Hubert, JP; Laville, M; Le Guern, S; Pradier, L | 1 |
| Antunes, E; Brain, SD; Costa, SK; de Nucci, G; Palframan, RT; Wilsoncroft, P | 1 |
| Chung, FZ; Huang, CC; Pu, Y; Tian, Y; Wu, LH | 1 |
| Inoue, H; Koshihara, Y; Nagata, N | 2 |
| Bernat, A; Herbert, JM | 1 |
| Advenier, C; Biyah, K; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Ansay, M; Delaunois, A; Gustin, P; Segura, P; Vargas, M | 1 |
| Lundberg, JM; Rinder, J | 1 |
| Brain, SD; Siney, L | 1 |
| Advenier, C; Bellamy, JF; Emonds-Alt, X; Molimard, M; Naline, E; Regoli, D | 1 |
| Blazy, C; Brelire, JC; Casellas, P; Derocq, JM; Emonds-Alt, X; Le Fur, G; Ségui, M | 1 |
| Kramer, JH; Phillips, TM; Weglicki, WB | 1 |
| Bertrand, C; Emanueli, C; Figini, M; Geppetti, P; Regoli, D; Sicuteri, R | 1 |
| Giuliani, S; Lecci, A; Maggi, CA; Tramontana, M | 1 |
| Bunnett, NW; Grady, EF; Martínez, V; Marvizón, JC; Mayer, EA | 1 |
| Advenier, C; Canet, E; Félétou, M; Girard, V | 1 |
| Bian, K; Bukoski, RD; Mupanomunda, M; Wang, Y | 1 |
| Chen, P; Hua, XY; Marsala, M; Nagy, I; Phillips, E; Polgar, E; Urban, L; Webb, M; Wollaston, L; Yaksh, TL | 1 |
| Criscuoli, M; Lippi, A; Maggi, CA; Santicioli, P | 1 |
| Bunnett, NW; Emanueli, C; Figini, M; Geppetti, P; Grady, EF; Madeddu, P; Parisi, D; Regoli, D | 1 |
| Belmonte, KE; Costello, RW; Fryer, AD; Jacoby, DB | 1 |
| Bannon, MJ; Hahn, MK | 1 |
| Blanchet, F; Gauchy, C; Glowinski, J; Kemel, ML; Perez, S; Soubrié, P | 1 |
| Bornstein, JC; Burcher, E; Johnson, PJ | 1 |
| Bourque, MJ; Robitaille, R | 1 |
| Bell, MI; Lee, K; Richardson, PJ | 1 |
| Kouznetsova, M; Nistri, A | 2 |
| Advenier, C; Boichot, E; Emonds-Alt, X; Germain, N; Lagente, V | 1 |
| Brain, SD; Towler, PK | 1 |
| Kanda, M; Kurahashi, K; Murase, K; Nakamura, S; Shirahase, H | 1 |
| Angelucci, D; Büchler, MW; Di Mola, FF; Di Sebastiano, P; Friess, H; Grossi, L; Innocenti, P; Marzio, L | 1 |
| Baluk, P; Bunnett, NW; McDonald, DM; Murphy, TJ; Thurston, G | 1 |
| Chen, P; Hua, XY; Marsala, M; Yaksh, TL | 1 |
| Bakhle, YS; Bell, C; Brogan, JD | 1 |
| Brain, SD; Brown, B; Hoult, JR; Pintér, E | 1 |
| Löfgren, O; Lundeberg, T; Qi, Y | 1 |
| Furness, JB; Mann, PT; Southwell, BR | 1 |
| Häbler, HJ; Jänig, W; Stegmann, JU; Timmermann, L | 1 |
| Perfumi, MC; Piccoli, M; Romagnoli, S; Santoni, G; Spreghini, E | 1 |
| Barbara, G; Bunnett, NW; Collins, SM; Figini, M; Geppetti, P; Gerard, C; Gerard, N; Grady, EF; Qiu, B; Sturiale, S | 1 |
| Buljubasich, S; Lau, WA; Pennefather, JN; Ventura, S | 1 |
| Goldhill, J; Porquet, MF; Selve, N | 1 |
| Chung, JM; Han, HC; Hong, SK; Kim, DY; Kim, SH; Kim, YI; Lee, HW; Na, HS; Shin, HC | 1 |
| Chahl, LA; Yip, J | 1 |
| Mustafa, S; Oriowo, MA | 1 |
| Bredenbröker, D; Fehmann, H; Klüber, D; Lange, A; Wagner, U; Wichert, P | 1 |
| Barthó, L; Corinaldesi, R; De Giorgio, R; Giuliani, S; Lecci, A; Maggi, CA; Sternini, C; Tramontana, M | 1 |
| Bialecki, R; Caccese, R; Graham, A | 1 |
| Lee, K; Pinnock, RD; Preston, Z; Richardson, PJ; Widdowson, L | 1 |
| Berggreen, E; Heyeraas, KJ | 1 |
| Holzer, P; Shahbazian, A | 1 |
| Bakhle, YS; Beddy, P; Bell, C; Campbell, VA; Foley, A | 1 |
| Belmonte, KE; Costello, RW; Evans, CM; Fryer, AD; Gleich, GJ; Jacoby, DB | 1 |
| Coupar, IM; Kerr, KP; Thai, B | 1 |
| Advenier, C; Beerens, D; Gustin, P; Halloy, D; Moreaux, B; Nemmar, A; Vincke, G | 1 |
| Broccardo, M; Improta, G | 1 |
| Amann, R; Egger, T; Schuligoi, R | 1 |
| Gobbetti, A; Petrelli, C; Zerani, M | 1 |
| Amadesi, S; Ansel, JC; Armstrong, CA; Bonaccorsi, P; Bunnett, NW; Geppetti, P; Gerard, NP; Grady, EF; Klein, R; Lu, B; Luger, TA; Olerud, JE; Scholzen, TE; Steinhoff, M | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; Selve, N | 1 |
| Gibbins, IL; Jobling, P; Messenger, JP | 1 |
| Han, HC; Hong, SK; Kang, HC; Kim, DY; Kim, YI; Lee, KJ; Na, HS; Shin, HC; Yoon, YW | 1 |
| Cassone, MC; Collino, M; Dianzani, C; Fantozzi, R; Ferrara, C; Lombardi, G | 1 |
| Baird, AW; Goldhill, J; Moriarty, D; O'Donoghue, DP; Selve, N | 1 |
| Antunes, E; Brain, SD; Camargo, EA; Costa, SK; de Nucci, G; Esquisatto, LC; Ribela, MT | 1 |
| Carpenter, TC; Stenmark, KR | 1 |
| Chen, CF; Chu, SJ; Lai, YL; Ma, MC | 1 |
| Bradesi, S; Bueno, L; Eutamene, H; Fioramonti, J | 1 |
| Glowinski, J; Godeheu, G; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Han, HC; Han, JS; Hong, SK; Hwang, JM; Kim, YI; Min, SS; Na, HS; Yoon, YW | 1 |
| Marvizón, JC; Wang, X | 1 |
| Chen, B; Hu, D; Tang, C; Tao, K; Wang, J; Zhu, X | 1 |
| Hirano, K; Kanaide, H; Naito, S; Nishimura, J; Takahashi, R | 1 |
| Bakhle, YS; Bell, C; Brady, F | 1 |
| De Swert, KO; Joos, GF; Leclere, PG; Lefebvre, RA; Pauwels, RA; Tournoy, KG | 1 |
| Heinke, B; Ikeda, H; Ruscheweyh, R; Sandkühler, J | 1 |
| Depoortere, I; Peeters, TL; Thielemans, L; Thijs, T | 1 |
| Aggio, A; Ciccocioppo, R; Loreto, MF; Onori, L; Taddei, G; Tonini, M; Vicini, R | 1 |
| Shea-Donohue, T; Zhao, A | 1 |
| Ogier, R; Raggenbass, M | 1 |
| Amemiya, T; Fujimura, M; Ishiura, Y; Kurashima, K; Myou, S; Nobata, K; Nonomura, A | 1 |
| Beaujouan, JC; Glowinski, J; Jabourian, M; Kemel, ML; Pérez, S; Soubrié, P | 1 |
| Gear, RW; Levine, JD; Tambeli, CH; Young, A | 1 |
| Bonham, AC; Bric, JM; Chen, CY; Evans, SJ; Joad, JP; Munch, PA; Pinkerton, KE | 1 |
| Amantini, C; Lucciarini, R; Perfumi, M; Piccoli, M; Pompei, P; Santoni, G | 1 |
| de Francischi, JN; Lisboa, MC; Santos, JM; Tatsuo, MA; Turchetti-Maia, RM | 1 |
| Bornstein, JC; Johnson, PJ | 1 |
| Baroni, S; Betti, L; Cassano, GB; Giannaccini, G; Giusti, L; Lucacchini, A; Marazziti, D | 1 |
| Bienenstock, J; Furuno, T; Ma, D; Nakanishi, M; van der Kleij, HP | 1 |
| Ikeda, M; Kadoi, J; Matsumoto, S; Nasu, M; Ohta, H; Shima, Y; Takeda, M; Tanimoto, T | 1 |
| Bianchi, C; Della Corte, L; Fantin, M; Manzalini, M; Marti, M; Morari, M | 1 |
| Nies, M; Ro, JY; Zhang, Y | 1 |
| Bell, EB; Beresford, LJ; Miyan, JA; Shepherd, AJ | 1 |
| Ikeda, M; Kadoi, J; Matsumoto, S; Nasu, M; Takeda, M; Tanimoto, T | 1 |
| Endo, D; Ikeda, T; Ishida, Y; Nishimori, T; Yoshioka, D | 1 |
| Brain, SD; Costa, SK; Muscará, MN; Poston, RN; Yshii, LM | 1 |
| Huizinga, JD; Nieuwmeyer, F; Ye, J | 1 |
| Bianchetti, A; Croci, T; Di Marzo, V; Di Palo, S; Ferla, G; Guagnini, F; Matias, I; Mukenge, S; Valenti, M | 1 |
| Benetti, E; Collino, M; Dianzani, C; Fantozzi, R; Gallicchio, M; Rosa, AC | 1 |
| Coicou, LG; Groth, RD; Mermelstein, PG; Seybold, VS | 1 |
| Hauer-Jensen, M; Kulkarni, A; Qiu, X; Wang, J | 1 |
| Brain, SD; Costa, SK; Gilmore, D; Hyslop, S; Starr, A | 1 |
| Fabry, Z; Johnson, MJ; Karman, J; Lee, J; Ling, C; Reinke, EK; Sandor, M; Weinstock, JV | 1 |
| Elliott, JC; Lysle, DT; Wagner, AF | 1 |
| Kim, JH; Lee, SE | 1 |
| Candenas, ML; Fernández-Sánchez, M; Orea, A; Pintado, CO; Pinto, FM; Ravina, CG; Seda, M | 1 |
| Barrett-Jolley, R; Womack, MD | 1 |
| Barrett-Jolley, R; Gent, TC; Morris, R; Womack, MD | 1 |
| Appleyard, CB; Morales, M; Santiago, C | 1 |
| Chen, J; Fu, CY; Han, M; Long, Y; Tian, XZ; Wang, R | 1 |
| Chen, Q; Fu, CY; Kong, ZQ; Long, Y; Wang, R | 1 |
| Kawana, S; Yamaoka, J | 1 |
| Adhikari, S; Bhatia, M; Hegde, A; Moochhala, SM; Ng, SW; Zhang, H | 1 |
| Dempsey, RJ; Park, SW; Satriotomo, I; Vemuganti, R; Yan, YP | 1 |
| Baumbauer, KM; Hoy, KC; Joynes, RL; Young, EE | 1 |
| Coste, J; Dallel, R; Luccarini, P; Miraucourt, LS; Voisin, DL | 1 |
| Feng, NH; Lee, HH; Ma, MC; Shiang, JC | 1 |
| Sachs, JR; Wang, DH; Xie, C | 1 |
| Alfaro, MF; Hyde, DM; Oslund, KL; Putney, LF; Schelegle, ES; Tyler, NK; Walby, WF | 1 |
| Holden, JE; Pizzi, JA | 1 |
| Antunes, E; Camargo, EA; de Nucci, G; Ferreira, T; Landucci, EC; Ribela, MT | 1 |
| Chen, YS; Huang, HS; Lee, SH; Ma, MC | 1 |
| Camargo, Lde L; Costa, SK; Denadai-Souza, A; Keeble, JE; Muscará, MN; Ribela, MT | 1 |
| De Ponti, F; Ursino, MG; Vasina, V | 1 |
| Hamity, MV; Hammond, DL; White, SR | 1 |
| Barreto, SG; Carati, CJ; Saccone, GT; Schloithe, AC; Toouli, J | 1 |
| Ikeda, T; Matsushima, O; Naono-Nakayama, R; Nishimori, T; Sunakawa, N | 1 |
| Câmara, PR; Casatti, CA; Cenac, N; Costa, SK; Denadai-Souza, A; Muscará, MN; Vergnolle, N; Yshii, LM | 1 |
| Alt, J; Cantoreggi, S; Li, Y; Pietra, C; Rojas, C; Sebastiani, S; Slusher, BS; Stathis, M; Thomas, AG; Zhang, J | 1 |
| Bonham, AC; Joad, JP; Pinkerton, KE; Sekizawa, S | 1 |
| Carlson Scholz, JA; Deng, Y; Franklin, R; Smith, PC; Williams-Fritze, MJ; Wilson, SR; Zeiss, C | 1 |
| Fish, EW; Heilig, M; Krouse, MC; Malanga, CJ; Robinson, JE; Thorsell, A | 1 |
| Nishishita, K; Okada, Y; Sato, T; Toda, K | 1 |
| Ikeda, K; Kawakami, K; Onimaru, H | 1 |
| Guillaume, V; Lemamy, GJ; Mouecoucou, J; Ndéboko, B; Oliver, C | 1 |
| Pietra, C; Rojas, C; Slusher, BS; Stathis, M | 1 |
| Chen, PX; Guo, HM; Huang, JH; Luo, YL; Zhang, YL; Zhou, WL; Zhu, YX | 1 |
| Fabi, A; Malaguti, P | 1 |
| Endo, T; Komatsu, Y; Yanagawa, Y | 1 |
| Decorps, J; Fromy, B; Gohin, S; Sigaudo-Roussel, D | 1 |
| He, JY; Jiang, LS; Jiang, SD; Zhang, YH; Zhao, ED; Zheng, XF | 1 |
| de Oliveira Borges, M; Fischer, L; Lavoranti, MI; Martynhak, BJ; Miksza, AF; Parada, CA; Sardi, NF; Tambeli, CH | 1 |
| Almeida, MPA; Bakhle, YS; Frade, TIC; Francischi, JN; Queiroz, BFG | 1 |
| Haruki, N; Hori, M; Inomata, T; Ohgoda, M; Tsukamoto, A | 1 |
| Andruszkow, H; Andruszkow, J; Greven, J; Hildebrand, F; Hofman, M; Kobbe, P; Kolejewska, A; Lammers, T; Möckel, D; Poeze, M; Rabenschlag, F; Teuben, MPJ | 1 |
1 review(s) available for quinuclidines and substance p
| Article | Year |
|---|---|
An update on palonosetron hydrochloride for the treatment of radio/chemotherapy-induced nausea and vomiting.
Topics: Animals; Antiemetics; Antineoplastic Agents; Drug Therapy, Combination; Humans; Isoquinolines; Nausea; Neurokinin-1 Receptor Antagonists; Palonosetron; Practice Guidelines as Topic; Quinuclidines; Radiotherapy; Serotonin 5-HT3 Receptor Antagonists; Substance P; Treatment Outcome; Vomiting | 2013 |
166 other study(ies) available for quinuclidines and substance p
| Article | Year |
|---|---|
Localization of agonist and antagonist binding domains of the human neurokinin-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Membrane; Chlorides; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin A; Neurokinin B; Oocytes; Polymerase Chain Reaction; Protein Conformation; Quinuclidines; Receptors, Neurokinin-2; Receptors, Neurotransmitter; Recombinant Proteins; Substance P; Xenopus | 1992 |
Characterization of the binding of a potent, selective, radioiodinated antagonist to the human neurokinin-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetinae; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Iodine Radioisotopes; Kinetics; Molecular Sequence Data; Quinuclidines; Receptors, Neurotransmitter; Receptors, Tachykinin; Substance P | 1992 |
Selectivity and specificity of new, non-peptide, quinuclidine antagonists of substance P.
Topics: Angiotensin II; Animals; Blood Vessels; Bradykinin; Cell Line; Guinea Pigs; Humans; Muscle Contraction; Norepinephrine; Quinuclidines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Substance P | 1991 |
Species differences in affinities of non-peptide antagonists for substance P receptors.
Topics: Animals; Binding, Competitive; Biphenyl Compounds; Cattle; Chickens; Guinea Pigs; Humans; Mice; Quinuclidines; Rabbits; Rats; Receptors, Neurokinin-1; Receptors, Neurotransmitter; Species Specificity; Substance P | 1991 |
Conserved HisVI-17 of the NK-1 receptor is involved in binding of non-peptide antagonists but not substance P.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Cell Membrane; Conserved Sequence; Dipeptides; Humans; Indoles; Isoindoles; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Piperidines; Protein Structure, Secondary; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Sequence Homology, Amino Acid; Substance P; Transfection | 1993 |
In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist.
Topics: Animals; Brain; Bronchoconstriction; Capillary Permeability; Cell Line; Dogs; Endothelium, Vascular; Guinea Pigs; Humans; Hypotension; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tumor Cells, Cultured | 1993 |
Characterization of the interaction of N-acyl-L-tryptophan benzyl ester neurokinin antagonists with the human neurokinin-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Histidine; Humans; Inositol Phosphates; Iodine Radioisotopes; Kinetics; Models, Molecular; Molecular Conformation; Mutagenesis, Site-Directed; Neurokinin-1 Receptor Antagonists; Protein Conformation; Quinuclidines; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Transfection; Tryptophan | 1994 |
Interaction of substance P with the second and seventh transmembrane domains of the neurokinin-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Structure, Secondary; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Recombinant Proteins; Substance P; Transfection | 1994 |
SR 140333, a novel, selective, and potent nonpeptide antagonist of the NK1 tachykinin receptor: characterization on the U373MG cell line.
Topics: Astrocytoma; Binding, Competitive; Calcium; Electric Conductivity; Genes, fos; Humans; Inositol Phosphates; Iodine Radioisotopes; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Succinimides; Taurine; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Aza-tricyclic substance P antagonists.
Topics: Animals; Bridged-Ring Compounds; Cell Line; Guinea Pigs; Humans; Male; Quinuclidines; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P; Ureter | 1994 |
Characterization of a fluorescent substance P analog.
Topics: Amino Acid Sequence; Anisotropy; Binding, Competitive; Buffers; Fluorescein; Fluoresceins; Fluorescent Dyes; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Iodine Radioisotopes; Lysine; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Spectrometry, Fluorescence; Substance P; Temperature | 1994 |
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
Topics: Animals; Atropine; Benzamides; Duodenum; Esophagus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Piperidines; Quinuclidines; Rats; Receptors, Tachykinin; Substance P | 1995 |
Substance P binding sites on intestinal lymphoid aggregates and blood vessels in inflammatory bowel disease correspond to authentic NK-1 receptors.
Topics: Binding Sites; Biphenyl Compounds; Blood Vessels; Humans; Indoles; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Isoindoles; Lymphoid Tissue; Neurokinin-1 Receptor Antagonists; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1994 |
Inhibition by SR 140333 of NK1 tachykinin receptor-evoked, nitric oxide-dependent vasodilatation in the hamster cheek pouch microvasculature in vivo.
Topics: Animals; Arginine; Arterioles; Cheek; Cricetinae; Male; Mesocricetus; Microcirculation; Mouth Mucosa; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Tachykinins; Vasoconstriction; Vasodilation | 1994 |
Effect of the tachykinin NK1 receptor antagonists, RP 67580 and SR 140333, on electrically-evoked substance P release from rat spinal cord.
Topics: Amino Acid Sequence; Analgesics; Animals; Biphenyl Compounds; Calcitonin Gene-Related Peptide; Electric Stimulation; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Isoindoles; Male; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1994 |
Tachykinin NK3 receptor mediates NANC hyperpolarization and relaxation via nitric oxide release in the circular muscle of the guinea-pig colon.
Topics: Animals; Apamin; Arginine; Atropine; Colon; Dose-Response Relationship, Drug; Guanethidine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; Muscle, Smooth; Neurokinin B; Nitric Oxide; Nitroarginine; Oligopeptides; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-3; Stereoisomerism; Substance P; Tetrodotoxin | 1994 |
Pharmacological analysis of the local and reflex responses to bradykinin on rat urinary bladder motility in vivo.
Topics: Adrenergic beta-Antagonists; Animals; Bradykinin; Capsaicin; Dose-Response Relationship, Drug; Indoles; Indomethacin; Injections, Spinal; Isoindoles; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Quinuclidines; Rats; Rats, Wistar; Reflex; Substance P; Urinary Bladder | 1995 |
Effects of substance P on cardiovascular regulation in the rabbit.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Electric Stimulation; Heart Rate; Injections, Intra-Arterial; Injections, Intraventricular; Male; Piperidines; Quinuclidines; Rabbits; Substance P; Vertebral Artery | 1995 |
Tachykinin effects on bladder activity in conscious normal rats.
Topics: Administration, Intravesical; Animals; Benzamides; Female; Indoles; Injections, Intra-Arterial; Isoindoles; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Urinary Bladder; Urination | 1995 |
Differential SAR of quinuclidine SP antagonists between rat and human-type receptors.
Topics: Animals; Humans; Molecular Structure; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Receptors, Neurokinin-1; Structure-Activity Relationship; Substance P | 1993 |
Substance P-evoked calcium mobilization and ionic current activation in the human astrocytoma cell line U 373 MG: pharmacological characterization.
Topics: Astrocytoma; Biphenyl Compounds; Calcium; Cell Line; Cytosol; Fluorescent Dyes; Humans; Indoles; Ion Channels; Isoindoles; Membrane Potentials; Quinuclidines; Receptors, Neurokinin-1; Receptors, Tachykinin; Spectrometry, Fluorescence; Substance P; Tumor Cells, Cultured | 1993 |
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider.
Topics: Animals; Edema; Male; Methysergide; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrilamine; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin Diseases; Spider Venoms; Substance P | 1996 |
Structural motifs encoded by individual exons of the human neurokinin-1 receptor gene interact differentially with selective agonists and antagonists.
Topics: Amino Acid Sequence; Cloning, Molecular; Exons; Humans; Iodine Radioisotopes; Molecular Sequence Data; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Phosphatidylinositols; Piperidines; Protein Binding; Pyrrolidonecarboxylic Acid; Quinuclidines; Radioligand Assay; Receptors, Neurokinin-1; Recombinant Fusion Proteins; Stereoisomerism; Substance P | 1996 |
Effect of the tachykinin receptor antagonists, SR 140333, FK 888, and SR 142801, on capsaicin-induced mouse ear oedema.
Topics: Animals; Binding Sites; Capsaicin; Dipeptides; Disease Models, Animal; Ear Diseases; Edema; Indoles; Injections, Intravenous; Lethal Dose 50; Male; Mice; Piperidines; Quinuclidines; Receptors, Tachykinin; Skin; Stereoisomerism; Structure-Activity Relationship; Substance P | 1996 |
Effect of SR 140333, a selective NK1 antagonist, on antigen-induced oedema formation in rat skin.
Topics: Allergens; Animals; Edema; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Skin Diseases; Substance P | 1996 |
Involvement of tachykinin NK1 and NK2 receptors in substance P-induced microvascular leakage hypersensitivity and airway hyperresponsiveness in guinea-pigs.
Topics: Animals; Benzamides; Bronchial Hyperreactivity; Capillary Leak Syndrome; Female; Glycopeptides; Guinea Pigs; Male; Metalloendopeptidases; Neurokinin-1 Receptor Antagonists; Piperidines; Premedication; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Stereoisomerism; Substance P | 1996 |
Interactions between acetylcholine and substance P effects on lung mechanics in the rabbit.
Topics: Acetylcholine; Analysis of Variance; Animals; Benzamides; Dose-Response Relationship, Drug; Female; Histamine; Lung; Male; Muscle, Smooth; Perfusion; Piperidines; Pulmonary Circulation; Pulmonary Edema; Quinuclidines; Rabbits; Substance P; Vasoconstriction | 1996 |
Involvement of tachykinin receptors in oedema formation and plasma extravasation induced by substance P, neurokinin A, and neurokinin B in mouse ear.
Topics: Animals; Capillary Permeability; Edema; Glycopeptides; Male; Mice; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Substance P | 1996 |
Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Female; Heart Rate; Male; Nasal Cavity; Nasal Mucosa; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Substance P; Swine; Vasodilation | 1996 |
Involvement of sensory neuropeptides in the development of plasma extravasation in rat dorsal skin following thermal injury.
Topics: Animals; Burns; Calcitonin Gene-Related Peptide; Edema; Male; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Skin; Substance P | 1996 |
Evidence for functional tachykinin NK1 receptors on human isolated small bronchi.
Topics: Benzamides; Biphenyl Compounds; Bronchi; Female; Hormone Antagonists; Humans; In Vitro Techniques; Indomethacin; Lung Neoplasms; Male; Middle Aged; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 1996 |
Effect of substance P on cytokine production by human astrocytic cells and blood mononuclear cells: characterization of novel tachykinin receptor antagonists.
Topics: Astrocytes; Humans; Interleukin-1; Interleukin-8; Monocytes; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Substance P; Tumor Cells, Cultured | 1996 |
Magnesium-deficiency-enhanced post-ischemic myocardial injury is reduced by substance P receptor blockade.
Topics: Animals; Cytokines; Drug Evaluation, Preclinical; Hemodynamics; Magnesium Deficiency; Male; Myocardial Reperfusion Injury; Neurokinin-1 Receptor Antagonists; Neuropeptides; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P | 1997 |
Differential activation of the epithelial and smooth muscle NK1 receptors by synthetic tachykinin agonists in guinea-pig trachea.
Topics: Animals; Dose-Response Relationship, Drug; Epithelium; Guinea Pigs; Male; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Peptide Fragments; Physalaemin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tachykinins; Trachea | 1997 |
Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists.
Topics: Anesthesia; Animals; Benzamides; Colon; Gastrointestinal Motility; Male; Neurokinin A; Peptide Fragments; Peptides, Cyclic; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1997 |
Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Capsaicin; Electric Stimulation; Endocytosis; Evoked Potentials; Ganglia, Spinal; Hyperalgesia; Long-Term Potentiation; Male; Microscopy, Confocal; Microscopy, Fluorescence; Models, Neurological; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1997 |
Effects of tachykinins and capsaicin on the mechanical and electrical activity of the guinea-pig isolated trachea.
Topics: Animals; Benzamides; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Isometric Contraction; Male; Membrane Potentials; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Potassium Channel Blockers; Quinuclidines; Receptors, Neurokinin-2; Substance P; Tachykinins; Tetraethylammonium; Trachea | 1997 |
Perivascular sensory nerve Ca2+ receptor and Ca2+-induced relaxation of isolated arteries.
Topics: Amino Acid Sequence; Animals; Benzamides; Calcium; Calcium-Binding Proteins; Endothelium, Vascular; Enzyme Inhibitors; Ganglia, Spinal; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Denervation; Muscle Relaxation; Muscle, Smooth, Vascular; Neurons, Afferent; Nitric Oxide Synthase; Piperidines; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger; Substance P; Vascular Resistance; Vasodilation | 1997 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Threshold; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Spinal Cord; Substance P | 1998 |
Depolarization evoked co-release of tachykinins from enteric nerves in the guinea-pig proximal colon.
Topics: Animals; Calcium; Colon; Enteric Nervous System; Guinea Pigs; Neurokinin A; Peptide Fragments; Piperidines; Potassium Chloride; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Tachykinin; Substance P; Tachykinins | 1998 |
Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Captopril; Coloring Agents; Data Interpretation, Statistical; Enalapril; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Indicators and Reagents; Indoles; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Organometallic Compounds; Piperidines; Quinuclidines; Substance P; Time Factors | 1998 |
Effects of tachykinin NK1 receptor antagonists on vagal hyperreactivity and neuronal M2 muscarinic receptor function in antigen challenged guinea-pigs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Electric Stimulation; Eosinophilia; Guinea Pigs; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Ovalbumin; Peptide Fragments; Pilocarpine; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Receptors, Tachykinin; Specific Pathogen-Free Organisms; Substance P; Trachea; Vagus Nerve | 1998 |
Tachykinin NK1 receptor antagonists enhance stress-induced c-fos in rat locus coeruleus.
Topics: Acetamides; Analgesics; Animals; Gene Expression Regulation; Genes, fos; Indoles; Isoindoles; Locus Coeruleus; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Restraint, Physical; Stereoisomerism; Stress, Physiological; Substance P; Synaptic Transmission | 1998 |
Distinct modifications by neurokinin1 (SR140333) and neurokinin2 (SR48968) tachykinin receptor antagonists of the N-methyl-D-aspartate-evoked release of acetylcholine in striosomes and matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Dopamine; Excitatory Amino Acid Agonists; In Vitro Techniques; Male; N-Methylaspartate; Neostriatum; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-2; Stimulation, Chemical; Substance P | 1998 |
Roles of neuronal NK1 and NK3 receptors in synaptic transmission during motility reflexes in the guinea-pig ileum.
Topics: Animals; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Synaptic Transmission | 1998 |
Endogenous peptidergic modulation of perisynaptic Schwann cells at the frog neuromuscular junction.
Topics: Acetylcholinesterase; Animals; Calcium; GTP-Binding Proteins; Muscarine; Muscle, Skeletal; Neostigmine; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptide Fragments; Pertussis Toxin; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rana pipiens; Receptors, Neurokinin-1; Schwann Cells; Substance P; Synapses; Virulence Factors, Bordetella | 1998 |
Characterization of the mechanism of action of tachykinins in rat striatal cholinergic interneurons.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Animals; Chelating Agents; Corpus Striatum; Diazonium Compounds; Electric Stimulation; Estrenes; Excitatory Amino Acid Antagonists; Guanosine 5'-O-(3-Thiotriphosphate); Interneurons; Male; Membrane Potentials; Patch-Clamp Techniques; Phenoxyacetates; Phosphodiesterase Inhibitors; Photochemistry; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Tetrodotoxin | 1998 |
Modulation by substance P of synaptic transmission in the mouse hippocampal slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Electric Stimulation; Evoked Potentials; Female; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; Mice; Microelectrodes; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tetrodotoxin; Time Factors | 1998 |
Effects of SR 140333 and SR 48968 on antigen and substance P-induced activation of guinea-pig alveolar macrophages.
Topics: Animals; Antigens; Arachidonic Acid; Benzamides; Bronchoalveolar Lavage; Bronchoalveolar Lavage Fluid; Endopeptidases; Glycopeptides; Guinea Pigs; Macrophage Activation; Macrophages, Alveolar; Male; Neurokinin-1 Receptor Antagonists; Ovalbumin; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1998 |
Activity of tachykinin NK1 and bradykinin B2 receptor antagonists, and an opioid ligand at different stimulation parameters in neurogenic inflammation in the rat.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Edema; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Male; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Receptors, Opioid, mu; Substance P; Time Factors | 1998 |
Endothelium-dependent contraction induced by substance P in canine cerebral arteries: involvement of NK1 receptors and thromboxane A2.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cerebral Arteries; Cyclooxygenase Inhibitors; Dogs; Endothelium, Vascular; Female; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Papaverine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P; Tachykinins; Thromboxane A2; Thromboxane-A Synthase; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid | 1999 |
Neurogenic plasma leakage in mouse airways.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzamides; Blood Vessels; Bradykinin; Bradykinin Receptor Antagonists; Capillary Permeability; Capsaicin; Captopril; Dose-Response Relationship, Drug; Evans Blue; Glycopeptides; Lung; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Piperidines; Protease Inhibitors; Quinuclidines; Receptors, Neurokinin-2; Skin; Specific Pathogen-Free Organisms; Substance P; Trachea; Urinary Bladder | 1999 |
Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids.
Topics: Amino Acids; Analgesics; Animals; Dinoprostone; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Isoindoles; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1999 |
Decreased vascular permeability response to substance P in airways of genetically hypertensive rats.
Topics: Animals; Blood Pressure; Capillary Permeability; Capsaicin; Hypertension; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P | 1999 |
Lack of evidence for tachykinin NK1 receptor-mediated neutrophil accumulation in the rat cutaneous microvasculature by thermal injury.
Topics: Abdomen; Animals; Bradykinin; Burns; Dose-Response Relationship, Drug; Edema; Hindlimb; Histamine; Inflammation; Interleukin-1; Male; Microcirculation; Mustard Plant; Neurokinin-1 Receptor Antagonists; Neutrophils; Peptide Fragments; Piperidines; Plant Extracts; Plant Oils; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Skin; Substance P; Time Factors | 1999 |
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
Topics: Animals; Burns; Disease Models, Animal; Edema; Follow-Up Studies; Inflammation; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain Measurement; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Skin Diseases; Substance P | 1999 |
Internalization of the neurokinin 1 receptor in rat myenteric neurons.
Topics: Animals; Endocytosis; Hypertonic Solutions; Ileum; Immunohistochemistry; Male; Microscopy, Confocal; Monensin; Myenteric Plexus; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Tachykinins | 1999 |
Involvement of neurokinins in antidromic vasodilatation in hairy and hairless skin of the rat hindlimb.
Topics: Afferent Pathways; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Electric Stimulation; Female; Ganglia, Spinal; Ganglia, Sympathetic; Hair; Hindlimb; Nerve Fibers; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Regional Blood Flow; Skin; Substance P; Vasodilation | 1999 |
Neurokinin type-1 receptor antagonist inhibits enhancement of T cell functions by substance P in normal and neuromanipulated capsaicin-treated rats.
Topics: Animals; Capsaicin; CD4-Positive T-Lymphocytes; CD5 Antigens; Cell Division; Concanavalin A; Female; Interleukin-2; Lymphocyte Activation; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Specific Pathogen-Free Organisms; Spleen; Substance P | 1999 |
Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.
Topics: Animals; Blood Proteins; Colitis; Dinitrofluorobenzene; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Peroxidase; Piperidines; Quinuclidines; Recombinant Proteins; Substance P | 1999 |
An immunohistochemical and pharmacological study of tachykinins in the rat and guinea-pig prostate glands.
Topics: Animals; Atropine; Benzamides; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Immunohistochemistry; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Peptide Fragments; Piperidines; Prostate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Substance P; Tachykinins | 1999 |
Antisecretory and relaxatory effects of tachykinin antagonists in the guinea-pig intestinal tract.
Topics: Animals; Benzamides; Guinea Pigs; Intestinal Mucosa; Intestines; Male; Models, Biological; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Piperidines; Quinuclidines; Substance P; Tachykinins | 1999 |
Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Circadian Rhythm; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Male; Neurotransmitter Agents; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retina; Substance P; Suprachiasmatic Nucleus; Synaptic Transmission; Visual Pathways | 1999 |
Distribution of Fos-like immunoreactivity in guinea-pig brain following administration of the neurokinin-1 receptor agonist, [SAR9,MET(O2)11]substance P.
Topics: Animals; Behavior, Animal; Brain; Cerebral Ventricles; Genes, fos; Guinea Pigs; Immunohistochemistry; Injections, Intraventricular; Motor Activity; Neurokinin-1 Receptor Antagonists; Organ Specificity; Piperidines; Proto-Oncogene Proteins c-fos; Quinuclidines; Receptors, Neurokinin-1; Reference Values; Substance P; Tyrosine 3-Monooxygenase | 1999 |
Inhibitory effect of capsaicin on cholinergic transmission in ovine airways: evidence for non-cholinergic contractions.
Topics: Acetylcholine; Animals; Capsaicin; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Lung; Muscle Contraction; Muscle, Smooth; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neuromuscular Junction; Peptides, Cyclic; Quinuclidines; Receptors, Drug; Receptors, Neurokinin-2; Serotonin; Sheep; Substance P; Synaptic Transmission; Trachea | 1999 |
Effects of selective tachykinin-receptor antagonists on tachykinin-induced airway mucus secretion in the rat.
Topics: Animals; Benzamides; Male; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Respiratory Mucosa; Substance P; Tachykinins; Trachea | 1999 |
Tachykinin NK(1)receptor-mediated inhibitory responses in the guinea-pig small intestine.
Topics: Adrenergic Agents; Animals; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanethidine; Guinea Pigs; Immunohistochemistry; Intestine, Small; Male; Myenteric Plexus; NADPH Dehydrogenase; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Peptide Fragments; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P; Tetrodotoxin | 1999 |
Pharmacological characterization of mucin secretion from CHO-K1-hNK(1)R cells.
Topics: Angiotensin II; Animals; Benzamides; Biological Transport; CHO Cells; Cricetinae; Endothelin-1; Glucosamine; Humans; Methacholine Chloride; Mucins; Muscarinic Agonists; Neurokinin A; Peptide Fragments; Phenylephrine; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Serotonin; Substance P; Transfection; Tritium; Vasoconstrictor Agents | 1999 |
Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; Alkaloids; Animals; Benzophenanthridines; Choline O-Acetyltransferase; Corpus Striatum; Electrophysiology; Enzyme Inhibitors; Estrenes; Excitatory Amino Acid Antagonists; In Situ Hybridization; Indoles; Interneurons; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurokinin A; Oligopeptides; omega-N-Methylarginine; Peptide Fragments; Phenanthridines; Phosphodiesterase Inhibitors; Piperidines; Pyrrolidinones; Quinoxalines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; RNA, Messenger; Signal Transduction; Substance P; Tachykinins; Tetrodotoxin; Tritium | 2000 |
Facilitation of cholinergic transmission by substance P methyl ester in the mouse hippocampal slice preparation.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Bicuculline; Carbachol; Cholinergic Agonists; Drug Synergism; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Hippocampus; Male; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Quinuclidines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Substance P; Tetrodotoxin; Valine | 2000 |
Effect of the sensory neuropeptide antagonists h-CGRP((8-37)) and SR 140.33 on pulpal and gingival blood flow in ferrets.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Dental Pulp; Electric Stimulation; Female; Ferrets; Gingiva; Infusions, Intra-Arterial; Laser-Doppler Flowmetry; Male; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Regional Blood Flow; Statistics, Nonparametric; Substance P | 2000 |
Differences in circular muscle contraction and peristaltic motor inhibition caused by tachykinin NK1 receptor agonists in the guinea-pig small intestine.
Topics: Adenosine Triphosphate; Animals; Enzyme Inhibitors; Female; Guinea Pigs; Intestine, Small; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neurokinin A; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Peristalsis; Piperidines; Purinergic P2 Receptor Antagonists; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Sincalide; Spasm; Substance P; Suramin; Tetrodotoxin | 2000 |
Reduced inflammation in genetically hypertensive rat airways is associated with reduced tachykinin NK(1) receptor numbers.
Topics: Animals; Binding, Competitive; Capillary Permeability; Diterpenes; Hypertension; Inflammation; Male; Membranes; Piperidines; Quinuclidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Spinal Cord; Substance P; Trachea; Tritium | 2000 |
Substance P-induced airway hyperreactivity is mediated by neuronal M(2) receptor dysfunction.
Topics: Animals; Antibodies; Blood Proteins; Bronchial Hyperreactivity; Cyclophosphamide; Electric Stimulation; Eosinophil Granule Proteins; Female; Guinea Pigs; Heparin; Neurokinin-1 Receptor Antagonists; Neurons; Piperidines; Quinuclidines; Receptor, Muscarinic M2; Receptors, Muscarinic; Ribonucleases; Substance P; Vagus Nerve | 2000 |
Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.
Topics: Animals; Benzamides; Captopril; Dose-Response Relationship, Drug; Esophagus; Guinea Pigs; In Vitro Techniques; Mucous Membrane; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Protease Inhibitors; Quinolines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Thiorphan | 2000 |
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Reflex; Substance P; Swine, Miniature | 2000 |
Effects of supraspinal administration of PG-SPI and PG-KII, two amphibian tachykinin peptides, on nociception in the rat.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Hot Temperature; Indoles; Male; Naloxone; Narcotic Antagonists; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pain Measurement; Pain Threshold; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Tachykinins; Time Factors | 2000 |
The tachykinin NK(1) receptor antagonist SR140333 prevents the increase of nerve growth factor in rat paw skin induced by substance P or neurogenic inflammation.
Topics: Animals; Hindlimb; Injections; Male; Nerve Growth Factor; Neurogenic Inflammation; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Skin; Substance P | 2000 |
Substance P downregulates basal and gonadotropin-releasing hormone-induced gonadotropin in vitro secretion by pituitary gland of crested newt, Triturus carnifex.
Topics: Androgens; Animals; Down-Regulation; Estivation; Female; Gonadotropin-Releasing Hormone; Gonadotropins; Hormone Antagonists; In Vitro Techniques; Male; Neurokinin-1 Receptor Antagonists; Oligopeptides; Pituitary Gland; Progesterone; Quinuclidines; Receptors, Neurokinin-1; Substance P; Triturus | 2000 |
Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Capsaicin; Croton Oil; Dermatitis, Allergic Contact; Dermatitis, Irritant; Enzyme Inhibitors; Female; Glycopeptides; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neprilysin; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Skin; Substance P | 2001 |
Potent NK1 antagonism by SR-140333 reduces rat colonic secretory response to immunocyte activation.
Topics: Animals; Benzamides; Capsaicin; Colon; Colonic Diseases, Functional; Electric Stimulation; Male; Mast Cells; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Stress, Physiological; Substance P | 2001 |
Differential expression of functionally identified and immunohistochemically identified NK(1) receptors on sympathetic neurons.
Topics: Action Potentials; Animals; Biotin; Coloring Agents; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Guinea Pigs; Image Processing, Computer-Assisted; Immune Sera; Male; Microelectrodes; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Protein Kinase C; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Substance P; Sympathetic Fibers, Postganglionic; Tachykinins | 2001 |
Substance p plays a critical role in photic resetting of the circadian pacemaker in the rat hypothalamus.
Topics: Animals; Biological Clocks; Circadian Rhythm; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypothalamus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Optic Nerve; Photoperiod; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Suprachiasmatic Nucleus | 2001 |
Priming effects of substance P on calcium changes evoked by interleukin-8 in human neutrophils.
Topics: Adult; Biphenyl Compounds; Calcium; Calcium Channels; Calcium Signaling; Dose-Response Relationship, Drug; Drug Synergism; Egtazic Acid; Humans; Interleukin-8; Ion Transport; Neutrophils; Peptide Fragments; Pyrrolidonecarboxylic Acid; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Recombinant Proteins; Substance P | 2001 |
Human colonic anti-secretory activity of the potent NK(1) antagonist, SR140333: assessment of potential anti-diarrhoeal activity in food allergy and inflammatory bowel disease.
Topics: Animals; Antidiarrheals; Capsaicin; Colitis, Ulcerative; Colon; Crohn Disease; Epithelial Cells; Food Hypersensitivity; Guinea Pigs; Humans; Immunoglobulin E; Inflammatory Bowel Diseases; Male; Mast Cells; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P; Tachykinins | 2001 |
The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Blood Proteins; Capillary Permeability; Capsaicin; Dose-Response Relationship, Drug; Female; Injections, Intradermal; Isotonic Solutions; Male; Mast Cells; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; p-Methoxy-N-methylphenethylamine; Peptide Fragments; Piperidines; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-2; Skin; Substance P; Theobromine | 2001 |
Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Gene Expression Regulation, Enzymologic; Hypoxia; Lung; Male; Methionine; Microcirculation; Neprilysin; Neurokinin-1 Receptor Antagonists; Oxygen; Piperidines; Protease Inhibitors; Pulmonary Edema; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; RNA, Messenger; Specific Pathogen-Free Organisms; Substance P; Water | 2001 |
Temporal increase in the reactivity of pulmonary vasculature to substance P in chronically hypoxic rats.
Topics: Altitude; Animals; Blood Pressure; Blood Vessels; Capillaries; Chronic Disease; Female; Hypoxia; In Vitro Techniques; Piperidines; Pulmonary Circulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors | 2002 |
Acute restraint stress activates functional NK1 receptor in the colon of female rats: involvement of steroids.
Topics: Animals; Colon; Female; Gonadal Steroid Hormones; Histamine Release; Hormone Antagonists; Mifepristone; Neurokinin-1 Receptor Antagonists; Ovary; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Restraint, Physical; Stress, Psychological; Substance P | 2002 |
Facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after acute and chronic suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; Animals; Benzamides; Corpus Striatum; Dopamine; Dopamine Antagonists; Enzyme Inhibitors; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Neurons; Oxidopamine; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2002 |
Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat.
Topics: Animals; Arthritis; Carrageenan; Dose-Response Relationship, Drug; Knee Joint; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Peripheral Nerves; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Weight-Bearing | 2002 |
Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons.
Topics: Animals; Cell Culture Techniques; Cell Membrane; Dendrites; Endocytosis; Immunohistochemistry; Microscopy, Confocal; Nociceptors; Pain; Posterior Horn Cells; Protease Inhibitors; Protein Transport; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Temperature; Time Factors; Transport Vesicles | 2002 |
[Substance P up-regulates the TGF-beta 1 mRNA expression of human dermal fibroblasts in vitro].
Topics: Cell Division; Cells, Cultured; Dermis; Fibroblasts; Gene Expression; Neurokinin-1 Receptor Antagonists; Quinuclidines; RNA, Messenger; Substance P; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2002 |
The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Topics: Animals; Benzamides; Calcium; Dose-Response Relationship, Drug; Glycopeptides; In Vitro Techniques; Male; Muscle Contraction; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Penis; Permeability; Piperidines; Quinuclidines; Rabbits; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Tachykinins; Type C Phospholipases | 2002 |
Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat.
Topics: Animals; Baroreflex; Blood Pressure; Diterpenes; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Rest; Substance P; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Modulatory role of tachykinin NK1 receptor in cholinergic contraction of mouse trachea.
Topics: Animals; Atropine; Chromatography, High Pressure Liquid; Electric Stimulation; Mice; Mice, Knockout; Muscle Contraction; Parasympathetic Nervous System; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Stereoisomerism; Substance P; Synaptic Transmission; Tetrodotoxin; Trachea | 2003 |
Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia.
Topics: Action Potentials; Animals; Calcium; Calcium Channels, T-Type; Excitatory Postsynaptic Potentials; Hyperalgesia; Ion Channel Gating; Long-Term Potentiation; Membrane Potentials; Nerve Fibers, Unmyelinated; Neurokinin-1 Receptor Antagonists; Nickel; Patch-Clamp Techniques; Posterior Horn Cells; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Signal Transduction; Substance P | 2003 |
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Purinergic P2 Receptor Antagonists; Quinuclidines; Rabbits; Serotonin Antagonists; Substance P; Suramin; Trinitrobenzenesulfonic Acid | 2003 |
Peristalsis regulation by tachykinin NK1 receptors in the rabbit isolated distal colon.
Topics: Alanine; Animals; Atropine; Colon; Drug Interactions; Enzyme Inhibitors; Indoles; Kinetics; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Peristalsis; Piperidines; Pyrrolidonecarboxylic Acid; Quinuclidines; Rabbits; Receptors, Neurokinin-1; Substance P | 2003 |
PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors.
Topics: Animals; Benzamides; Capsaicin; Female; Intestine, Small; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurokinin-1 Receptor Antagonists; Oligopeptides; Piperidines; Quinuclidines; Receptor, PAR-2; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Thrombin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Tetrodotoxin; Trypsin | 2003 |
Action of tachykinins in the rat hippocampus: modulation of inhibitory synaptic transmission.
Topics: Animals; Animals, Newborn; Bicuculline; Drug Interactions; Excitatory Amino Acid Antagonists; GABA Antagonists; Hippocampus; In Vitro Techniques; Interneurons; Membrane Potentials; Neural Inhibition; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuropeptides; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Tachykinins; Time Factors | 2003 |
Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction.
Topics: Aerosols; Animals; Bronchi; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Disease Models, Animal; Eosinophils; Guinea Pigs; Immunization, Passive; Male; Methacholine Chloride; Piperidines; Platelet Activating Factor; Quinuclidines; Substance P; Water | 2003 |
The new neurokinin 1-sensitive receptor mediates the facilitation by endogenous tachykinins of the NMDA-evoked release of acetylcholine after suppression of dopaminergic transmission in the matrix of the rat striatum.
Topics: Acetylcholine; alpha-Methyltyrosine; Animals; Corpus Striatum; Dopamine; In Vitro Techniques; Male; Morpholines; N-Methylaspartate; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Perfusion; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Substance P; Synaptic Transmission; Tachykinins; Tetrazoles | 2003 |
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 2003 |
Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P.
Topics: Aerosols; Age Factors; Animals; Brain Stem; Bronchoconstriction; Citric Acid; Cough; Guinea Pigs; Homocysteine; Injections; Lung; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Respiration; Solitary Nucleus; Substance P; Tobacco Smoke Pollution | 2004 |
Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.
Topics: Adjuvants, Immunologic; Animals; Animals, Newborn; Atrophy; Autocrine Communication; Binding Sites; Capsaicin; Cell Death; Cell Division; Concanavalin A; Growth Substances; Male; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; RNA, Messenger; Substance P; T-Lymphocytes; Thymus Gland; Up-Regulation | 2004 |
Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Topics: Animals; Benzamides; Cell Movement; Dose-Response Relationship, Drug; Female; Formaldehyde; Injections, Intraperitoneal; Leukocytes; Models, Biological; Neurokinin A; Neurokinin B; Neurokinin-1 Receptor Antagonists; Peritoneal Cavity; Peritoneal Lavage; Piperidines; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Substance P; Time Factors | 2004 |
Neurokinin-1 and -3 receptor blockade inhibits slow excitatory synaptic transmission in myenteric neurons and reveals slow inhibitory input.
Topics: Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Male; Myenteric Plexus; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Neurons; Peptide Fragments; Phentolamine; Piperazines; Piperidines; Quinuclidines; Reaction Time; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Substance P; Synaptic Transmission | 2004 |
Absence of NK1 receptors in human blood lymphocytes and granulocytes.
Topics: Adult; Animals; Antidepressive Agents; Cerebral Cortex; Female; Granulocytes; Humans; Lymphocytes; Male; Piperidines; Quinuclidines; Rats; Receptors, Neurokinin-1; Stereoisomerism; Stress, Psychological; Substance P | 2004 |
Bone marrow-derived mast cells in mice respond in co-culture to scorpion venom activation of superior cervical ganglion neurites according to level of expression of NK-1 receptors.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Cell Line; Coculture Techniques; Fluorescent Antibody Technique; Interleukin-1; Mast Cells; Mice; Mice, Inbred BALB C; Neurites; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Scorpion Venoms; Substance P; Superior Cervical Ganglion | 2004 |
Temporomandibular joint inflammation potentiates the excitability of trigeminal root ganglion neurons innervating the facial skin in rats.
Topics: Animals; Behavior, Animal; Cell Count; Cell Size; Cells, Cultured; Drug Interactions; Electric Stimulation; Escape Reaction; Face; Freund's Adjuvant; Functional Laterality; Gene Expression Regulation; Immunohistochemistry; Male; Membrane Potentials; Neurofilament Proteins; Neurons; Patch-Clamp Techniques; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensory Thresholds; Skin; Stilbamidines; Substance P; Temporomandibular Joint Disorders; Trigeminal Ganglion | 2005 |
Striatal glutamate release evoked in vivo by NMDA is dependent upon ongoing neuronal activity in the substantia nigra, endogenous striatal substance P and dopamine.
Topics: Adrenergic Agents; Animals; Benzazepines; Bicuculline; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; GABA Antagonists; Glutamic Acid; Magnesium; Male; N-Methylaspartate; Neurons; Oxidopamine; Piperidines; Potassium Chloride; Quinuclidines; Raclopride; Rats; Rats, Sprague-Dawley; Substance P; Substantia Nigra; Tetrodotoxin; Time Factors | 2005 |
Substance P does not play a critical role in neurogenic inflammation in the rat masseter muscle.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Edema; Inflammation Mediators; Male; Masseter Muscle; Mustard Plant; Neurogenic Inflammation; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Plant Extracts; Plant Oils; Pyrrolidonecarboxylic Acid; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P | 2005 |
Mobilisation of specific T cells from lymph nodes in contact sensitivity requires substance P.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cell Movement; Dermatitis, Contact; Dinitrochlorobenzene; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; Lymph Nodes; Mice; Nerve Fibers; Quinuclidines; Skin; Substance P; Sympathectomy, Chemical; T-Lymphocytes | 2005 |
Activation of NK1 receptor of trigeminal root ganglion via substance P paracrine mechanism contributes to the mechanical allodynia in the temporomandibular joint inflammation in rats.
Topics: Action Potentials; Animals; Behavior, Animal; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Escape Reaction; Freund's Adjuvant; Functional Laterality; Male; Models, Biological; Neural Conduction; Neurons; Nociceptors; Pain Threshold; Paracrine Communication; Physical Stimulation; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Substance P; Temporomandibular Joint Disorders; Trigeminal Ganglion | 2005 |
Effect of intrathecal administration of hemokinin-1 on the withdrawal response to noxious thermal stimulation of the rat hind paw.
Topics: Animals; Behavior, Animal; Drug Interactions; Hindlimb; Hot Temperature; Male; Pain; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins; Time Factors | 2006 |
Pivotal role of endogenous tachykinins and the NK1 receptor in mediating leukocyte accumulation, in the absence of oedema formation, in response to TNFalpha in the cutaneous microvasculature.
Topics: Albumins; Analysis of Variance; Animals; Capsaicin; Dose-Response Relationship, Drug; Female; Glycoproteins; Immunohistochemistry; Inflammation; Injections, Intradermal; Iodine Isotopes; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Skin; Substance P; Tachykinins; Time Factors; Tumor Necrosis Factor-alpha | 2006 |
Ava[L-Pro9,N-MeLeu10] substance P(7-11) (GR 73632) and Sar9, Met(O2)11 increase distention-induced peristalsis through activation of neurokinin-1 receptors on smooth muscle and interstitial cells of cajal.
Topics: Action Potentials; Animals; Coiled Bodies; Dilatation; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Mice; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peristalsis; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aged; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Case-Control Studies; Colon; Diverticulum; Endocannabinoids; Female; Glycerides; Humans; Imidazoles; Isoproterenol; Male; Middle Aged; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Neurokinin-1 Receptor Antagonists; Piperidines; Polyunsaturated Alkamides; Propanolamines; Pyrazoles; Quinuclidines; Rimonabant; Substance P; Tetrodotoxin | 2006 |
Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Benzamides; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Dinoprostone; Dose-Response Relationship, Drug; Endothelial Cells; Flavonoids; Furans; Gene Expression Regulation; Humans; Imidazoles; MAP Kinase Signaling System; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurokinin-1 Receptor Antagonists; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; RNA, Messenger; Substance P; Time Factors; Umbilical Veins | 2006 |
Substance P initiates NFAT-dependent gene expression in spinal neurons.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Calcium Channel Blockers; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Hippocampus; Indoles; Neurokinin A; Neurons, Afferent; NFATC Transcription Factors; Nimodipine; Phorbol 12,13-Dibutyrate; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spinal Cord; Spleen; Substance P; Tacrolimus | 2006 |
Calcitonin gene-related peptide and substance P regulate the intestinal radiation response.
Topics: Adenosine; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Disease Models, Animal; Gene Expression Profiling; Intestines; Male; Multivariate Analysis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Quinuclidines; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Reverse Transcriptase Polymerase Chain Reaction; Substance P; X-Rays | 2006 |
How important are NK1 receptors for influencing microvascular inflammation and itch in the skin? Studies using Phoneutria nigriventer venom.
Topics: Administration, Topical; Animals; Dose-Response Relationship, Drug; Edema; Female; Injections, Intradermal; Injections, Intravenous; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Piperidines; Pruritus; Quinuclidines; Receptors, Neurokinin-1; Skin; Spider Venoms; Substance P; Vasculitis, Leukocytoclastic, Cutaneous | 2006 |
Substance P receptor mediated maintenance of chronic inflammation in EAE.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Chronic Disease; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Immunity, Cellular; Immunosuppression Therapy; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2006 |
Neurokinin 1 receptor signaling mediates sex differences in mu and kappa opioid-induced enhancement of contact hypersensitivity.
Topics: Analgesics, Opioid; Animals; Benzamides; Dermatitis, Contact; Drug Interactions; Female; Male; Morphine; Neurokinin-1 Receptor Antagonists; Piperidines; Pyrrolidines; Quinuclidines; Rats; Rats, Inbred F344; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sex Characteristics; Signal Transduction; Specific Pathogen-Free Organisms; Substance P | 2006 |
Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Disease Models, Animal; Dose-Response Relationship, Drug; Lidocaine; Male; Neuralgia; Pain Measurement; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Spinal Nerves; Substance P; Time Factors | 2007 |
A role for tachykinins in the regulation of human sperm motility.
Topics: Benzamides; Humans; Immunohistochemistry; Male; Neurokinin A; Neurokinin B; Piperidines; Quinuclidines; Receptors, Tachykinin; Sperm Motility; Spermatozoa; Substance P; Tachykinins | 2007 |
Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats.
Topics: Action Potentials; Animals; Dorsomedial Hypothalamic Nucleus; Glutamic Acid; Neurons; Paraventricular Hypothalamic Nucleus; Quinuclidines; Rats; Receptors, Neurokinin-1; Substance P | 2007 |
Substance P targets sympathetic control neurons in the paraventricular nucleus.
Topics: Animals; Blood Pressure; Enzyme Activators; Enzyme Inhibitors; gamma-Aminobutyric Acid; Heart Rate; Kidney; Male; Neural Inhibition; Neurons; Organ Culture Techniques; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Protein Kinase C; Quinuclidines; Rats; Rats, Wistar; Receptors, GABA-A; Receptors, Neurokinin-1; Substance P; Sympathetic Nervous System | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
Topics: Animals; Anti-Infective Agents, Local; Clotrimazole; Coronary Vessels; Dequalinium; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperidines; Potassium; Potassium Channel Blockers; Protein Precursors; Quinoxalines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Prostaglandin; Substance P; Swine; Tachykinins; Tetraethylammonium; Vasodilation | 2007 |
Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats.
Topics: Anesthesia; Animals; Atropine; Benzamides; Blood Pressure; Male; Mice; Muscarinic Antagonists; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Protein Precursors; Quinuclidines; Rats; Receptors, Neurokinin-2; Substance P; Tachykinins; Vagotomy; Vagus Nerve | 2007 |
A transient unresponsive state of self-scratching behaviour is induced in mice by skin-scratching stimulation.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Physical Stimulation; Pruritus; Quinuclidines; Self Stimulation; Signal Transduction; Skin Physiological Phenomena; Substance P | 2007 |
Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury.
Topics: Animals; Cecum; Gene Deletion; Hydrogen Sulfide; Inflammation Mediators; Ligation; Lung; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Protein Precursors; Punctures; Quinuclidines; Sepsis; Substance P; Sulfides; Tachykinins; Up-Regulation | 2007 |
Substance P is a promoter of adult neural progenitor cell proliferation under normal and ischemic conditions.
Topics: Adult Stem Cells; Animals; Brain Ischemia; Cell Culture Techniques; Cell Proliferation; Doublecortin Protein; Male; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Quinuclidines; Rats; Rats, Inbred SHR; Substance P | 2007 |
Neurokinin receptors modulate the impact of uncontrollable stimulation on adaptive spinal plasticity.
Topics: Adaptation, Psychological; Animals; Electroshock; Female; Learning; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neuronal Plasticity; Pain; Peptide Fragments; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Tachykinin; Spinal Cord; Spinal Cord Injuries; Substance P; Vocalization, Animal | 2007 |
Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons.
Topics: Afferent Pathways; Animals; Male; Nerve Fibers, Unmyelinated; Neural Pathways; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Nociceptors; Pain; Piperidines; Posterior Horn Cells; Presynaptic Terminals; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Synaptic Transmission; Trigeminal Caudal Nucleus; Trigeminal Nerve; Trigeminal Nuclei | 2008 |
Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys.
Topics: Action Potentials; Animals; Blood Pressure; Capsaicin; Cell Membrane; Cytosol; Diterpenes; Electrophysiology; Female; Kidney; Kidney Pelvis; Mechanoreceptors; Models, Biological; Neurokinin-1 Receptor Antagonists; Perfusion; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory System Agents; Substance P; TRPV Cation Channels; Ubiquitin Thiolesterase | 2008 |
Interdependent regulation of afferent renal nerve activity and renal function: role of transient receptor potential vanilloid type 1, neurokinin 1, and calcitonin gene-related peptide receptors.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Ganglia, Spinal; Isoindoles; Kidney Pelvis; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Peptide Fragments; Quinuclidines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Substance P; TRPV Cation Channels | 2008 |
Activation of neurokinin-1 receptors during ozone inhalation contributes to epithelial injury and repair.
Topics: Animals; Apoptosis; Bronchi; Immunohistochemistry; Inhalation; Male; Neurokinin-1 Receptor Antagonists; Ozone; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Respiratory Mucosa; Substance P; Trachea | 2008 |
Lateral hypothalamic-induced antinociception may be mediated by a substance P connection with the rostral ventromedial medulla.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Carbachol; Cobalt; Female; Hypothalamic Area, Lateral; Medulla Oblongata; Neurons; Pain Measurement; Pain Threshold; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin Antagonists; Stilbamidines; Substance P; Time Factors | 2008 |
Role of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A2.
Topics: Acute Disease; Amylases; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Disease Models, Animal; Lung; Male; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Piperidines; Pneumonia; Quinuclidines; Rats; Rats, Wistar; Receptor, Bradykinin B2; Receptors, Neurokinin-1; Substance P; Tumor Necrosis Factor-alpha | 2008 |
Mechanosensitive N-methyl-D-aspartate receptors contribute to sensory activation in the rat renal pelvis.
Topics: Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Kidney; Kidney Cortex; Kidney Medulla; Mechanoreceptors; Neurons, Afferent; Quinuclidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Substance P | 2008 |
Participation of peripheral tachykinin NK1 receptors in the carrageenan-induced inflammation of the rat temporomandibular joint.
Topics: Animals; Carrageenan; Data Interpretation, Statistical; Extravasation of Diagnostic and Therapeutic Materials; Inflammation; Interleukin-1beta; Leukocyte Count; Male; Neurokinin-1 Receptor Antagonists; Pain; Peroxidase; Piperidines; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Neurokinin-1; Serum Albumin, Radio-Iodinated; Substance P; Temporomandibular Joint Disorders; Tumor Necrosis Factor-alpha | 2009 |
Protection from DNBS-induced colitis by the tachykinin NK(1) receptor antagonist SR140333 in rats.
Topics: Animals; Colitis; Dinitrofluorobenzene; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Substance P; Substrate Specificity; Tumor Necrosis Factor-alpha | 2009 |
Effects of neurokinin-1 receptor agonism and antagonism in the rostral ventromedial medulla of rats with acute or persistent inflammatory nociception.
Topics: Animals; Capsaicin; Central Nervous System Agents; Freund's Adjuvant; Hot Temperature; Male; Medulla Oblongata; Mustard Plant; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Piperidines; Plant Oils; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Substance P; Time Factors | 2010 |
The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice.
Topics: Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Edema; Galanin; Mice; Neurokinin-1 Receptor Antagonists; Pancreas; Pancreas, Exocrine; Pancreatitis; Peroxidase; Quinuclidines; Receptors, Galanin; Receptors, Neurokinin-1; Substance P | 2010 |
Subcutaneous injection of endokinin C/D attenuates carrageenan-induced inflammation.
Topics: Analgesics, Non-Narcotic; Animals; Carrageenan; Dose-Response Relationship, Drug; Edema; Hindlimb; Hot Temperature; Humans; Hyperalgesia; Inflammation; Injections, Subcutaneous; Male; Neuritis; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Peripheral Nervous System Agents; Quinuclidines; Rats; Rats, Sprague-Dawley; Reaction Time; Substance P; Tachykinins | 2010 |
PAR(2) and temporomandibular joint inflammation in the rat.
Topics: Animals; Arthritis; Arthropathy, Neurogenic; Immunity, Innate; Injections, Intra-Articular; Male; Nerve Fibers; Neuroimmunomodulation; Neurokinin-1 Receptor Antagonists; Neurons; Neutrophil Infiltration; Neutrophils; Oligopeptides; Pain Measurement; Piperidines; Plasma; Quinuclidines; Rats; Rats, Wistar; Receptor, PAR-2; Sensory Receptor Cells; Substance P; Temporomandibular Joint; Temporomandibular Joint Disorders; Trigeminal Ganglion; Trypsin; Ubiquitin Thiolesterase | 2010 |
The antiemetic 5-HT3 receptor antagonist Palonosetron inhibits substance P-mediated responses in vitro and in vivo.
Topics: Action Potentials; Animals; Antiemetics; Antineoplastic Agents; Calcium; Cell Line; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Isoquinolines; Male; Neurokinin-1 Receptor Antagonists; Neurons; Nodose Ganglion; Palonosetron; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin 5-HT3 Receptor Antagonists; Substance P; Vomiting | 2010 |
Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure.
Topics: Animals; Brain Stem; Female; Macaca mulatta; Maternal Exposure; Membrane Potentials; Neurokinin-1 Receptor Antagonists; Neurons; Nicotiana; Patch-Clamp Techniques; Piperidines; Pregnancy; Quinuclidines; Receptors, Neurokinin-1; Solitary Nucleus; Substance P; Tobacco Smoke Pollution | 2011 |
Maropitant citrate for treatment of ulcerative dermatitis in mice with a C57BL/6 background.
Topics: Animals; Antipruritics; Dermatitis; Female; Male; Mice; Mice, Inbred C57BL; Neurokinin-1 Receptor Antagonists; Pruritus; Quinuclidines; Rodent Diseases; Skin Ulcer; Substance P | 2011 |
Potentiation of brain stimulation reward by morphine: effects of neurokinin-1 receptor antagonism.
Topics: Analgesics, Opioid; Animals; Brain; Dose-Response Relationship, Drug; Electric Stimulation; Male; Mice; Mice, Inbred C57BL; Morphine; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Reinforcement, Psychology; Reward; Substance P | 2012 |
Efferent fibers innervate gustatory and mechanosensitive afferent fibers in frog fungiform papillae.
Topics: Action Potentials; Afferent Pathways; Animals; Efferent Pathways; Electric Stimulation; Electrodes; Glossopharyngeal Nerve; Mechanotransduction, Cellular; Nerve Fibers; Quinuclidines; Rana catesbeiana; Substance P; Synaptic Potentials; Taste Buds; Taste Perception | 2012 |
Postsynaptic mechanisms of CO(2) responses in parafacial respiratory neurons of newborn rats.
Topics: Adenosine Diphosphate; Animals; Animals, Newborn; Cadmium; Calcium; Calcium Channel Blockers; Carbon Dioxide; Homeodomain Proteins; Hypercapnia; In Vitro Techniques; Magnesium; Medulla Oblongata; Neurokinin-1 Receptor Antagonists; Neurons; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Purinergic P2; Respiratory Center; Substance P; Tetrodotoxin; Transcription Factors | 2012 |
Substance P stimulates Growth Hormone (GH) and GH-Releasing Hormone (GHRH) secretions through tachykinin NK2 receptors in sheep.
Topics: Animals; Benzamides; Growth Hormone; Growth Hormone-Releasing Hormone; Male; Piperidines; Quinuclidines; Receptors, Neurokinin-2; Sheep; Somatostatin; Substance P | 2012 |
Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects.
Topics: Animals; Cell Line, Tumor; Drug Synergism; Isoquinolines; Neurokinin-1 Receptor Antagonists; Palonosetron; Pyridines; Quinuclidines; Receptors, Neurokinin-1; Serotonin 5-HT3 Receptor Antagonists; Substance P | 2012 |
Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Anions; Biological Transport; Capsaicin; Cells, Cultured; Chlorides; Colforsin; Epinephrine; Epithelial Cells; Formaldehyde; Imines; Male; Nerve Endings; ortho-Aminobenzoates; Quinuclidines; Rats; Respiratory Mucosa; Substance P; Trachea; TRPV Cation Channels | 2013 |
Substance P Activates Ca2+-Permeable Nonselective Cation Channels through a Phosphatidylcholine-Specific Phospholipase C Signaling Pathway in nNOS-Expressing GABAergic Neurons in Visual Cortex.
Topics: Animals; Anthracenes; Boron Compounds; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Agents; GABAergic Neurons; Glutamate Decarboxylase; Imidazoles; In Vitro Techniques; Isoindoles; Mice; Mice, Transgenic; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase Type III; Patch-Clamp Techniques; Piperidines; Quinolines; Quinuclidines; Signal Transduction; Substance P; Type C Phospholipases; Visual Cortex | 2016 |
Sensory nerves contribute to cutaneous vasodilator response to cathodal stimulation in healthy rats.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Electrodes; Electrophysiology; Hydrogen-Ion Concentration; Laser-Doppler Flowmetry; Male; Microcirculation; Peptide Fragments; Piperidines; Quinuclidines; Rats; Rats, Wistar; Receptors, Neurokinin-1; Sensory Receptor Cells; Skin; Substance P; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2015 |
Inhibition of substance P signaling aggravates the bone loss in ovariectomy-induced osteoporosis.
Topics: Animals; Body Weight; Bone Density; Down-Regulation; Estradiol; Female; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Organ Size; Osteogenesis; Osteoporosis; Ovariectomy; Quinuclidines; RANK Ligand; RNA, Messenger; Signal Transduction; Substance P; Tibia; Uterus | 2016 |
TRPA1, substance P, histamine and 5-hydroxytryptamine interact in an interdependent way to induce nociception.
Topics: Acetanilides; Animals; Histamine; Histamine H1 Antagonists; Isothiocyanates; Male; Oligonucleotides, Antisense; p-Methoxy-N-methylphenethylamine; Pain; Piperazines; Purines; Pyrilamine; Quinuclidines; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Receptors, Histamine H1; Receptors, Neurokinin-1; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Substance P; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
Ketamine-xylazine anaesthesia and orofacial administration of substance P: A lethal combination in rats.
Topics: Anesthesia; Animals; Edema; Isoflurane; Ketamine; Male; Models, Animal; Piperidines; Quinuclidines; Rats, Wistar; Substance P; Xylazine | 2017 |
The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neurokinin-1 Receptor Antagonists; Pancreatitis; Peroxidase; Quinuclidines; Receptors, Neurokinin-1; Substance P | 2018 |
Effect of neurokinin-1-receptor blockage on fracture healing in rats.
Topics: Animals; Collagen Type I; Collagen Type II; Disease Models, Animal; Femoral Fractures; Fracture Healing; Gene Expression Regulation, Neoplastic; Male; Neurokinin-1 Receptor Antagonists; Osteocalcin; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Substance P; Treatment Outcome | 2019 |