quinuclidines has been researched along with sabcomeline in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bromidge, SM; Brown, F; Clark, MS; Hatcher, JP; Hawkins, J; Loudon, JM; Noy, G; Orlek, BS; Riley, GJ | 1 |
| Bromidge, SM; Brown, F; Cassidy, F; Clark, MS; Dabbs, S; Hadley, MS; Hawkins, J; Loudon, JM; Naylor, CB; Orlek, BS; Riley, GJ | 1 |
| Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W | 1 |
| Cilia, J; Harries, MH; Hunter, AJ; Samson, NA | 1 |
| Clark, MS; Hagan, JJ; Hatcher, JP; Loudon, JM | 1 |
| Brown, AM; Hunter, AJ; Middlemiss, DN; Watson, JM | 1 |
| Gray, JA; Hodges, H; Hunter, AJ; Peters, S | 1 |
| Cohen, ML; Stengel, PW | 1 |
| Ensinger, HA; Gaida, W; Hammer, R; Meier, D; Raschig, A; Walland, A; Wienrich, M | 1 |
| Hosoi, R; Inoue, O; Ishida, J; Kobayashi, K; Yamaguchi, M | 1 |
| Balasubramanian, A; Ganju, RK; Groopman, JE | 1 |
| Dai, J; Li, Z; Meltzer, HY; Roseman, AS; Snigdha, S | 1 |
12 other study(ies) available for quinuclidines and sabcomeline
| Article | Year |
|---|---|
SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors.
Topics: Acetylcholine; Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Guinea Pigs; Hemodynamics; Humans; Ileum; Imines; Male; Mice; Muscarinic Agonists; Quinuclidines; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic | 1997 |
Design of [R-(Z)]-(+)-alpha-(methoxyimino)-1-azabicyclo[2.2.2]octane-3-acetonitri le (SB 202026), a functionally selective azabicyclic muscarinic M1 agonist incorporating the N-methoxy imidoyl nitrile group as a novel ester bioisostere.
Topics: Alzheimer Disease; Animals; Binding Sites; Blood Pressure; Brain; CHO Cells; Cricetinae; Electroencephalography; Heart Rate; Humans; Imines; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Molecular Structure; Muscarinic Agonists; Protein Binding; Quinuclidines; Rats; Rats, Inbred Strains; Receptor, Muscarinic M1; Receptors, Muscarinic; Recombinant Proteins; Stereoisomerism; Tremor | 1997 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Cholinesterase Inhibitors; Dihydropyridines; Dose-Response Relationship, Drug; Hydrolysis; Hypothermia; Imines; Lithium; Male; Mice; Mice, Inbred Strains; Muscarinic Agonists; Oximes; Parasympathomimetics; Phosphatidylinositols; Physostigmine; Pilocarpine; Pyridines; Quinuclidines; Radioligand Assay; Salivation; Tacrine; Tetrazoles; Thiadiazoles; Tremor | 1998 |
The profile of sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, in the marmoset.
Topics: Alzheimer Disease; Animals; Blood Pressure; Callithrix; Female; Imines; Learning; Male; Memory; Muscarinic Agonists; Parasympathomimetics; Pattern Recognition, Visual; Quinuclidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Succinimides | 1998 |
Sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, reverses delay-induced deficits in the T-maze.
Topics: Animals; Cholinesterase Inhibitors; Imines; Male; Maze Learning; Muscarinic Agonists; Quinuclidines; Rats; Receptor, Muscarinic M1; Receptors, Muscarinic; Succinimides; Tacrine; Taste | 1998 |
In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cell Membrane; Cells, Cultured; Cerebral Cortex; Drug Interactions; Heart; Imines; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth, Vascular; Myocardium; Oxotremorine; Quinuclidines; Quinuclidinyl Benzilate; Radioligand Assay; Rats; Rats, Sprague-Dawley | 1999 |
Counteractive effects of a partial (sabcomeline) and a full (RS86) muscarinic receptor agonist on deficits in radial maze performance induced by S-AMPA lesions of the basal forebrain and medial septal area.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Ganglionic Stimulants; Imines; Male; Maze Learning; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Prosencephalon; Quinuclidines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Succinimides; Time Factors | 1999 |
Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
Topics: Animals; Atropine; Bradycardia; Carbachol; Drug Interactions; Heart; Heart Rate; Imines; In Vitro Techniques; Mice; Muscarinic Agonists; Pyridines; Quinuclidines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, Muscarinic; Thiadiazoles | 2001 |
Pharmacodynamic profile of the M1 agonist talsaclidine in animals and man.
Topics: Adrenergic beta-Antagonists; Adult; Alzheimer Disease; Animals; Bronchial Spasm; Dose-Response Relationship, Drug; Electroencephalography; Female; Guinea Pigs; Heart; Humans; Imines; In Vitro Techniques; Male; Middle Aged; Muscarinic Agonists; Muscle, Smooth; Neurons; Propanolamines; Quinuclidines; Rabbits; Rats; Receptors, Muscarinic | 2001 |
Effect of sabcomeline on muscarinic and dopamine receptor binding in intact mouse brain.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Corpus Striatum; Diagnostic Techniques, Radioisotope; Dose-Response Relationship, Drug; Imines; Male; Metabolic Clearance Rate; Mice; Mice, Inbred Strains; Organ Specificity; Piperidines; Protein Binding; Quinuclidines; Quinuclidinyl Benzilate; Raclopride; Radionuclide Imaging; Radiopharmaceuticals; Receptors, Dopamine; Spiperone; Tissue Distribution; Tritium | 2003 |
Hepatitis C virus and HIV envelope proteins collaboratively mediate interleukin-8 secretion through activation of p38 MAP kinase and SHP2 in hepatocytes.
Topics: Carcinoma, Hepatocellular; Cell Line; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hepacivirus; Hepatocytes; HIV Envelope Protein gp120; Humans; Imines; Interleukin-8; Intracellular Signaling Peptides and Proteins; Kinetics; Liver Neoplasms; Microcirculation; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Quinuclidines; Tumor Cells, Cultured; Viral Envelope Proteins | 2003 |
Effect of muscarinic receptor agonists xanomeline and sabcomeline on acetylcholine and dopamine efflux in the rat brain; comparison with effects of 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) and N-desmethylclozapine
Topics: Acetylcholine; Animals; Antipsychotic Agents; Benzoxazines; Brain; Clozapine; Dopamine; Drug Synergism; Imines; Male; Nucleus Accumbens; Pirenzepine; Prefrontal Cortex; Pyridines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Risperidone; Thiadiazoles | 2008 |