Page last updated: 2024-08-18

quinuclidines and m 8218

quinuclidines has been researched along with m 8218 in 106 studies

Research

Studies (106)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.94)	18.7374
1990's	2 (1.89)	18.2507
2000's	20 (18.87)	29.6817
2010's	69 (65.09)	24.3611
2020's	14 (13.21)	2.80

Authors

Authors	Studies
Gao, JH; Wen, GL; Zhang, QK	2
Cheng, ZJ; Yang, ZP	1
Guo, JF; Qiao, JZ; Ruan, JX; Xue, M; Yuan, SL; Zhang, ZQ	1
Chen, LF; Han, XY; Liu, CH; Liu, H; Liu, KL; Wu, B; Zhong, BH	1
Chen, YM; Liang, SW	1
Huang, C; Jin, H; Wang, A; Wang, Z; Zhang, Q; Zhang, Z	2
Liu, K; Qiao, J; Ruan, J; Xu, Y; Xue, M; Yuan, S; Zhang, Z	1
Wang, A; Wang, Z; Wei, J; Zhang, Q; Zhang, Z	1
Jia, B; Li, J; Wang, C; Wang, Y; Zhan, J; Zhang, Z	1
Jia, BH; Lei, LR; Wang, YL	1
Gong, P; Jiang, H; Liu, H; Zhang, Y; Zhao, GK	1
Chen, KZ; Huang, Y; Li, J; Pan, JH; Zhang, L	1
Li, X; Li, Y; Liu, K; Liu, Y; Ruan, J; Wang, M; Xue, M	1
Li, K; Lü, L; Yin, L	1
Gan, J; Jiang, G; Shen, W; Wu, H; Xu, S	1
Huang, Y; Li, Z; Liu, J; Luo, N; Wang, S	1
Chen, S; Liao, Z; Meng, X; Mo, Z; Xiao, H; Yan, X	1
Chen, SJ; Liao, Z; Meng, XM; Mo, ZJ; Xiao, HT; Yan, XY	2
Dong, CM; Shi, H	1
Wang, LL; Wu, XJ; Xia, ZY; Zhan, LY	1
Guo, YZ; Lin, L; Zhang, LC	1
Liang, MZ; Nan, F; Qin, YP; Xiang, J; Yu, Q	1
Li, SL; Ma, ZF; Ouyang, YH; Song, W; Zhao, N	1
Lin, J; Luo, Z; Wei, XC	1
Cai, DS; Jin, BB; Jin, Z; Pei, L	1
Chen, C; Chen, K; Liu, Y; Wang, Y; Zhan, J; Zhang, Z	1
Cao, YQ; Chen, HX; Fan, QY	1
Li, BQ; Liu, HM; Nie, SN; Qian, XM; Shao, DB; Sun, HC	1
Jian, XD; Lin, DW; Liu, F; Liu, J; Ning, Q; Zhang, ZC; Zhao, B	1
Lin, HQ; Wang, JR; Wang, KW	1
Kang, YQ; Leng, YF; Wang, T; Xue, X; Zhang, Y	3
Gu, S; Li, M; Ma, T; Sun, X; Wang, Y	1
Cao, HJ; Diao, YG; Jin, Q; Sun, YJ; Zhang, TZ	1
Chen, DT; Chen, Y; Gu, MN; He, SS; Lin, CS; Zong, SL	1
Chen, C; Chen, K; Wang, YL; Zhan, J; Zhang, ZZ	1
Deng, LL; Liu, JF; Liu, MM; Wang, DM; Wang, JZ; Xiao, J	1
Han, X; Li, H; Li, J; Liu, M; Qian, Z	1
Luo, T; Meng, QT; Song, XM; Wang, LL; Wu, XJ; Xia, ZY; Zhan, LY	1
Gu, PF; Li, Y; Shang, Y	1
Cui, XG; Li, WZ; Pan, P; Shi, WD; Wang, WW; Zhang, B	1
Gu, M; Ouyang, F; Zeng, B; Zhang, A; Zhang, Z; Zhuang, Y	1
Shu, LJ; Wei, XC	1
Yu, LQ; Zheng, XQ	1
Liao, Z; Tong, RS; Xiao, HT	1
Chen, JW; Ren, Y; Tan, ZM; Wang, J; Xu, YJ; Zhu, MM; Zhu, Y	1
Mashour, GA; Pandit, JJ; Picton, P	1
Diao, YG; Song, DD; Sun, YJ; Zhang, TZ; Zhou, J	1
Liu, YF; Su, LJ; Zhou, CL	1
Gu, SL; Hu, B; Ma, TF; Ma, X; Qin, SJ; Wang, Y; Yan, JZ; Zhang, Y; Zhou, CH; Zhou, L	1
Cao, HJ; Diao, YG; Sun, YJ; Zhang, TZ; Zhou, J	1
Gu, S; Li, M; Ma, T; Sun, XJ; Wang, Y; Wang, YG; Zhou, L	1
Li, G; Ma, LL; Ma, X; Qiu, M; Wang, YP; Zhang, HX; Zhang, SD; Zheng, Y	1
Chang, Y; Liu, X; Mao, S; Wei, Q; Yang, Q; Yao, Z	1
Cui, J; He, XH; Li, CS; Song, YG	1
Cai, W; Su, Z	1
Chen, C; Chen, Y; He, J; Huang, C; Zhang, Y	1
Wang, D; Yan, T	1
Chen, K; Li, JJ; Wang, YL; Wang, YP; Xiao, F; Zhan, J; Zhang, ZZ	1
Chen, Y; Liu, L; Mo, LQ; Mou, M; Ren, CH; Wu, GM; Zhou, J	1
Liang, MJ; Zhang, Y	1
Cao, HJ; Chen, KY; Ge, J; Pei, L; Yu, DM; Zhang, TZ; Zhou, J	1
An, Y; Fang, Y; Feng, W; Jing, S; Sun, Y; Wang, Q; Wei, Z; Zang, Y; Zhao, L	1
Lin, D; Ma, J; Wang, Z; Xue, Y	1
Shu, Y; Yang, Y; Zhang, P	1
Chen, Y; Huang, X; Wang, J; Wang, L; Wu, G; Yang, X; Zhang, L; Zhao, W	1
Duomao, L; Jun, M; Yanli, Y; Yanyan, X; Yi, C; Zhaoqi, W	1
Lin, D; Liu, W; Ma, J; Tan, H; Wang, Z; Zhang, L	1
Lin, D; Ma, J; Tan, H; Wang, Z; Yang, Y	1
Ma, J; Yang, Y; Zhao, L	1
Li, HJ; Li, WO; Liang, XQ; Wang, DX; Wang, T; Yan, T; Zhu, SN	1
Chen, Y; Zhao, Y	1
Leng, Y; Liu, HM; Meng, QT; Song, XM; Wang, EY; Wu, XJ; Xia, ZY; Zhan, LY; Zhao, B	1
Cui, B; Lin, D; Ma, J; Ren, J	1
Liu, QS; Wang, YL; Xiao, F; Yuan, QH; Zhan, J; Zhang, ZZ; Zheng, F	1
Bai, T; Li, X; Sun, Y; Wang, S; Wang, W; Zhao, Y; Zhu, R	1
Chang, S; Feng, M; Wang, L; Yuan, P	1
Gao, Y; Lin, D; Ma, J; Tan, H; Wang, Y	1
Gao, Y; Ma, J; Wang, Y	1
Han, L; Liao, Z; Shi, T; Tong, R; Xiao, H	1
Jiang, L; Wu, S; Xie, P; Zheng, Z	1
Duan, W; Kong, Q; Song, X; Wu, X; Xia, Z; Zhan, L	1
Ap, L; F, X; J, Z; K, C; Qh, Y; Qs, L; Qw, H; Yl, W; Z, L; Zz, Z	1
Ailing, Y; Hongyu, X; Liwu, Z; Qingting, W; Xiaoling, S; Xin, L	1
Chen, Q; Ma, Y; Wang, Q; Yang, X; Ye, S	1
Chen, J; Chen, M; Fang, D; Lin, Q; Wang, S; Weng, J	1
Ma, C; Wang, C; Wang, P; Zhao, H	1
Dong, W; Sun, C; Sun, X; Zhai, L	1
Fu, C; Guo, C; Huang, J; Pei, Q; Yang, G; Yang, S; Yang, X; Zhang, X	1
Cui, BQ; Lin, DM; Ma, J; Ren, JY; Wang, CB; Wang, ZQ; Yang, YL	1
Feng, Z; Kang, Y; Li, Y; Wen, H; Zheng, J; Zhu, J	1
Chang, Y; Li, Y; Liu, Z; Yu, J; Yu, L	1
Fang, NX; Yao, YT; Ying, H; Yuan, X; Zhang, YB	1
Liu, F; Wang, X; Wu, L; Xu, M	1
Cao, X; Ding, Z; Li, N; Lu, T; Min, X; Sun, J	1
Jing, G; Kong, Q; Ming, T; Song, X; Wu, X; Yuan, M	1
Cheng, T; Li, N; Wang, DX; Wang, LK; Xiong, GL; Yang, XD	1
Li, WO; Liang, XQ; Liu, Y; Sessler, DI; Wang, DX; Wang, GJ; Wang, T; Wu, LY; Yan, T; Yu, KY; Zhu, SN	1
Chen, L; Tan, HB; Zhao, Q	1
Chen, H; He, M; Li, S; Luo, A; Zhao, Y	1
Chen, J; Li, R; Lu, T; Sun, J	1
Chen, Y; He, F; Lu, Y; Mao, Q; Xie, Y; Zhou, L	1

Reviews

4 review(s) available for quinuclidines and m 8218

Article	Year
[Meta analysis of outcomes of penehyclidine hydrochloride and atropine in treatment of acute organophosphorus poisoning]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2010, Volume: 28, Issue:1 Topics: Atropine; Humans; Organophosphate Poisoning; Poisoning; Quinuclidines	2010
Penehyclidine hydrochloride: a potential drug for treating COPD by attenuating Toll-like receptors. Drug design, development and therapy, 2012, Volume: 6 Topics: Cholinergic Antagonists; Humans; Myeloid Differentiation Factor 88; Pulmonary Disease, Chronic Obstructive; Quinuclidines; Toll-Like Receptors	2012
Pleiotropic effects and pharmacological properties of penehyclidine hydrochloride. Drug design, development and therapy, 2018, Volume: 12 Topics: Animals; Cholinergic Antagonists; Humans; Organophosphate Poisoning; Preanesthetic Medication; Quinuclidines	2018
Penehyclidine Hydrochloride Premedication Is Not Associated with Increased Incidence of Post-Operative Cognitive Dysfunction or Delirium:A Systemic Review and Meta-Analysis. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih, 2020, Jun-30, Volume: 35, Issue:2 Topics: Cognitive Dysfunction; Delirium; Humans; Incidence; Postoperative Complications; Quinuclidines	2020

Trials

22 trial(s) available for quinuclidines and m 8218

Article	Year
[Effects of penehyclidine hydrochloride or atropine combined with neostigmine for antagonizing residual neuromuscular block on patient's hemodynamics]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2005, Volume: 25, Issue:12 Topics: Abdomen; Adult; Anesthesia, General; Atropine; Blood Circulation; Female; Humans; Male; Neostigmine; Neuromuscular Blocking Agents; Quinuclidines	2005
[Effects of penehyclidine hydrochloride on the splanchnic perfusion of patients with septic shock]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2008, Volume: 20, Issue:3 Topics: Adult; Aged; Female; Humans; Male; Microcirculation; Middle Aged; Perfusion; Quinuclidines; Resuscitation; Shock, Septic; Solanaceous Alkaloids; Viscera	2008
[Application of penehyclidine hydrochloride in whole lung lavage]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2010, Volume: 28, Issue:7 Topics: Adult; Bronchoalveolar Lavage; Humans; Male; Middle Aged; Pneumoconiosis; Quinuclidines	2010
Effect of penehyclidine hydrochloride on patients with acute lung injury and its mechanisms. Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2010, Volume: 13, Issue:6 Topics: Acute Lung Injury; Cytokines; Heart Rate; Humans; Oxygen; Prognosis; Quinuclidines; Toll-Like Receptor 4	2010
[Effect of penehyclidine hydrochloride as preoperation drug for elder on HRV]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2008, Volume: 24, Issue:1 Topics: Aged; Atropine; Electrocardiography; Female; Heart Rate; Humans; Male; Muscarinic Antagonists; Preoperative Care; Quinuclidines	2008
[Curative effect of penehyclidine hydrochloride injection as an auxiliary therapy for serious pneumonia complicated by respiratory failure in children]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2011, Volume: 13, Issue:9 Topics: Child; Child, Preschool; Female; Humans; Infant; Injections; Male; Pneumonia; Quinuclidines; Respiratory Insufficiency	2011
Penehyclidine enhances the efficacy of tropisetron in prevention of PONV following gynecological laparoscopic surgery. Journal of anesthesia, 2012, Volume: 26, Issue:6 Topics: Adolescent; Adult; Anesthesia, General; Antiemetics; Cholinergic Antagonists; Drug Therapy, Combination; Female; Gynecologic Surgical Procedures; Humans; Indoles; Laparoscopy; Postoperative Nausea and Vomiting; Quinuclidines; Tropisetron; Young Adult	2012
[Effect of Penehyclidine hydrochloride in systemic inflammatory response syndrome caused by cardiopulmonary bypass]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2012, Volume: 43, Issue:4 Topics: Adult; Cardiopulmonary Bypass; Double-Blind Method; Female; Heart Valve Prosthesis Implantation; Humans; Male; Middle Aged; Pneumonia; Quinuclidines; Rheumatic Heart Disease; Systemic Inflammatory Response Syndrome; Young Adult	2012
Effect of penehyclidine hydrochloride on the incidence of intra-operative awareness in Chinese patients undergoing breast cancer surgery during general anaesthesia. Anaesthesia, 2013, Volume: 68, Issue:2 Topics: Adolescent; Adult; Aged; Anesthesia, General; Breast Neoplasms; China; Cholinergic Antagonists; Double-Blind Method; Female; Humans; Incidence; Intraoperative Awareness; Middle Aged; Prospective Studies; Quinuclidines; Young Adult	2013
Penehyclidine hydrochloride preserves the intestinal barrier function in patients undergoing cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery, 2013, Volume: 146, Issue:1 Topics: Cardiopulmonary Bypass; Endotoxemia; Female; Humans; Intestinal Mucosa; Male; Middle Aged; Prospective Studies; Quinuclidines; Systemic Inflammatory Response Syndrome	2013
[Clinical efficacy of ulinastatin combined with penehyclidine hydrochloride in prevention and treatment of highly irritant gas poisoning]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2013, Volume: 31, Issue:6 Topics: Adult; Female; Gas Poisoning; Glycoproteins; Humans; Male; Middle Aged; Quinuclidines; Treatment Outcome; Young Adult	2013
[Effects of penehyclidine inhalation on postoperative pulmonary complications of elderly patients after long-duration surgery]. Zhonghua yi xue za zhi, 2014, Jan-14, Volume: 94, Issue:2 Topics: Administration, Inhalation; Aged; Aged, 80 and over; Anesthesia; Bronchial Spasm; Double-Blind Method; Female; Humans; Intubation, Intratracheal; Lung Diseases; Male; Postoperative Complications; Prospective Studies; Quinuclidines	2014
Clinical analysis of penehyclidine hydrochloride combined with hemoperfusion in the treatment of acute severe organophosphorus pesticide poisoning. Genetics and molecular research : GMR, 2015, May-11, Volume: 14, Issue:2 Topics: Adolescent; Adult; Aged; Coma; Female; Hemoperfusion; Humans; Male; Middle Aged; Organophosphate Poisoning; Organophosphorus Compounds; Pesticides; Quinuclidines; Respiration, Artificial	2015
Development and validation of an improved HPLC-MS/MS method for comparative pharmacokinetics of penehyclidine hydrochloride following a single intravenous or intramuscular injection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2015, Nov-01, Volume: 1004 Topics: Area Under Curve; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Humans; Injections, Intramuscular; Injections, Intravenous; Limit of Detection; Male; Quinuclidines; Reference Standards; Tandem Mass Spectrometry	2015
Prophylactic penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients: study protocol of a randomized controlled trial. Trials, 2017, Nov-28, Volume: 18, Issue:1 Topics: Administration, Inhalation; Aged; Aged, 80 and over; Cause of Death; China; Clinical Protocols; Double-Blind Method; Drug Administration Schedule; Female; Humans; Incidence; Length of Stay; Lung Diseases; Male; Middle Aged; Muscarinic Antagonists; Postoperative Complications; Prospective Studies; Quinuclidines; Research Design; Risk Factors; Time Factors; Treatment Outcome	2017
Penehyclidine hydrochloride on postoperatively cognitive function. Medical hypotheses, 2019, Volume: 129 Topics: Aged; Anesthesia, General; Atropine; Cholinergic Antagonists; Cognition; Cognitive Dysfunction; Cytokines; Delirium; Female; Humans; Incidence; Inflammation; Lung Neoplasms; Male; Mental Status and Dementia Tests; Postoperative Complications; Postoperative Period; Quinuclidines; Thoracoscopy; Treatment Outcome	2019
Safety of the muscarinic receptor-antagonist (R,R)-penehyclidine fumarate in healthy subjects: A phase 1 randomized, double-blind, single-dose escalation study . International journal of clinical pharmacology and therapeutics, 2020, Volume: 58, Issue:3 Topics: Administration, Oral; Adult; Area Under Curve; Dose-Response Relationship, Drug; Double-Blind Method; Female; Fumarates; Humans; Infusions, Intravenous; Male; Muscarinic Antagonists; Quinuclidines; Young Adult	2020
Penehyclidine mitigates postoperative nausea and vomiting and intraoperative oculocardiac reflex in patients undergoing strabismus surgery: a prospective, randomized, double-blind comparison. BMC anesthesiology, 2021, 02-13, Volume: 21, Issue:1 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Double-Blind Method; Female; Humans; Intraoperative Complications; Male; Middle Aged; Postoperative Nausea and Vomiting; Quinuclidines; Reflex, Oculocardiac; Strabismus; Young Adult	2021
Penehyclidine for prevention of postoperative nausea and vomiting following bimaxillary orthognathic surgery: a randomized, double-blind, controlled trial. Journal of anesthesia, 2022, Volume: 36, Issue:1 Topics: Antiemetics; Double-Blind Method; Humans; Orthognathic Surgery; Postoperative Nausea and Vomiting; Quinuclidines	2022
Prophylactic Penehyclidine Inhalation for Prevention of Postoperative Pulmonary Complications in High-risk Patients: A Double-blind Randomized Trial. Anesthesiology, 2022, 04-01, Volume: 136, Issue:4 Topics: Bronchial Spasm; Double-Blind Method; Female; Humans; Male; Middle Aged; Postoperative Complications; Pulmonary Atelectasis; Quinuclidines	2022
Evaluation of penehyclidine for prevention of post operative nausea and vomitting in patients undergoing total thyroidectomy under total intravenous anaesthesia with propofol-remifentanil. BMC anesthesiology, 2022, 10-14, Volume: 22, Issue:1 Topics: Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Antiemetics; Cholinergic Antagonists; Humans; Piperidines; Postoperative Nausea and Vomiting; Propofol; Quinuclidines; Remifentanil; Saline Solution; Thyroidectomy	2022
Effects of penehyclidine hydrochloride combined with dexmedetomidine on pulmonary function in patients undergoing heart valve surgery: a double-blind, randomized trial. BMC anesthesiology, 2023, 07-13, Volume: 23, Issue:1 Topics: Dexmedetomidine; Double-Blind Method; Heart Valves; Humans; Quinuclidines	2023

Other Studies

80 other study(ies) available for quinuclidines and m 8218

Article	Year
[Studies on the stereochemistry and structure-activity relationship of cholinolytic compounds 3-(2-phenyl-2-cyclopentyl-2-hydroxyl-ethoxy)-quinuclidines]. Yao xue xue bao = Acta pharmaceutica Sinica, 1990, Volume: 25, Issue:12 Topics: Animals; Cyclopentanes; Guinea Pigs; Mice; Parasympatholytics; Quinuclidines; Stereoisomerism; Structure-Activity Relationship	1990
[The synthesis and separation of optically pure hydroxy ethers]. Yao xue xue bao = Acta pharmaceutica Sinica, 1987, Volume: 22, Issue:9 Topics: Animals; Chemical Phenomena; Chemistry; Parasympatholytics; Quinuclidines; Rats; Stereoisomerism	1987
[The degradation mechanism of penequine hydrochloride in aqueous solutions]. Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:8 Topics: Cyclopentanes; Drug Stability; Parasympatholytics; Quinuclidines; Solutions	1993
[Identification of the metabolites of penehyclidine hydrochloride raceme in rats by LC-MS/MS and ion cluster]. Yao xue xue bao = Acta pharmaceutica Sinica, 2002, Volume: 37, Issue:10 Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Male; Molecular Structure; Quinuclidines; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism	2002
Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018). Bioorganic & medicinal chemistry letters, 2005, Apr-15, Volume: 15, Issue:8 Topics: Cholinergic Antagonists; Cyclopentanes; Quinuclidines; Stereoisomerism	2005
The pre- and post-natal toxicity of penequine hydrochloride in mice. Reproductive toxicology (Elmsford, N.Y.), 2006, Volume: 22, Issue:4 Topics: Administration, Oral; Animals; Animals, Newborn; Body Weight; Cholinergic Antagonists; Cyclopentanes; Dose-Response Relationship, Drug; Female; Gestational Age; Litter Size; Liver; Lung; Male; Mice; Molecular Structure; Organ Size; Pregnancy; Pregnancy Outcome; Prenatal Exposure Delayed Effects; Quinuclidines; Sex Factors; Sexual Behavior, Animal; Testis; Toxicity Tests	2006
Determination of penehyclidine by gas chromatographic-mass spectrometry and its application to pharmacokinetics in humans, rabbits and mice. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, Nov-07, Volume: 843, Issue:2 Topics: Adult; Animals; Drug Stability; Gas Chromatography-Mass Spectrometry; Humans; Male; Mice; Quinuclidines; Rabbits; Reproducibility of Results; Sensitivity and Specificity	2006
Embryo-fetal development toxicity of prenatal exposure to penequine hydrochloride intramuscularly in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:4 Topics: Abnormalities, Drug-Induced; Animals; Body Weight; Bone and Bones; Cyclopentanes; Embryonic Development; Female; Fetal Development; Injections, Intramuscular; Male; No-Observed-Adverse-Effect Level; Quinuclidines; Rats; Rats, Wistar	2007
Fertility and early embryonic development toxicity of penequine hydrochloride in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2007, Volume: 45, Issue:6 Topics: Animals; Animals, Newborn; Body Weight; Cholinergic Antagonists; Cyclopentanes; Female; Fetal Development; Litter Size; Male; Mice; Mice, Inbred Strains; Organ Size; Pregnancy; Quinuclidines; Random Allocation; Sex Ratio; Sperm Count; Sperm Motility	2007
Protective effects of penehyclidine hydrochloride on septic mice and its mechanism. Shock (Augusta, Ga.), 2007, Volume: 28, Issue:6 Topics: Animals; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression; Heart Rate; Lipid Peroxidation; Liver; Lung; Malondialdehyde; Mice; Microscopy, Electron, Transmission; Nitric Oxide Synthase Type II; Pulmonary Alveoli; Quinuclidines; Random Allocation; RNA, Messenger; Sepsis; Superoxide Dismutase; Survival Analysis; Tumor Necrosis Factor-alpha	2007
[Protective effect of penehyclidine hydrochloride on lung injury in mice with sepsis and its mechanism]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2007, Volume: 19, Issue:10 Topics: Animals; Disease Models, Animal; Female; Lung; Lung Injury; Malondialdehyde; Mice; Nitric Oxide Synthase; Quinuclidines; Random Allocation; Sepsis; Superoxide Dismutase	2007
Penehyclidine prevents nuclear factor-kappaB activation in acute lung injury induced by lipopolysaccharide. The Journal of pharmacy and pharmacology, 2008, Volume: 60, Issue:9 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; DNA; Gene Expression Regulation; Interleukin-1beta; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Male; Neutrophils; NF-kappa B; Peroxidase; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Necrosis Factor-alpha	2008
Structural elucidation of in vivo metabolites of penehyclidine in rats by the method of liquid chromatography-mass spectrometry, gas chromatography-mass spectrometry and isotope ion cluster. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Sep-15, Volume: 873, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Male; Metabolic Networks and Pathways; Quinuclidines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2008
[Clinical observation of penehyclidine hydrochloride as the preanesthetic medication before operation for patients with cleft lip/palate]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2008, Volume: 26, Issue:4 Topics: Cleft Lip; Cleft Palate; Female; Humans; Male; Preanesthetic Medication; Quinuclidines	2008
Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway. Pharmacological research, 2009, Volume: 60, Issue:4 Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Extracellular Signal-Regulated MAP Kinases; L-Lactate Dehydrogenase; Lipopolysaccharides; Lung; Male; Malondialdehyde; MAP Kinase Signaling System; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peroxidase; Quinuclidines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase	2009
[Effect of penehyclidine hydrochloride on oleic acid-acute lung injury in canine during ventilation]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2009, Volume: 23, Issue:5 Topics: Acute Lung Injury; Animals; Dogs; Male; Oleic Acid; Quinuclidines; Respiration, Artificial; Respiratory Distress Syndrome	2009
Effects of the selective muscarinic receptor antagonist penehyclidine hydrochloride on the respiratory tract. Die Pharmazie, 2009, Volume: 64, Issue:5 Topics: Animals; Atropine; Bronchoalveolar Lavage Fluid; Cyclic AMP; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle, Smooth, Vascular; Quinuclidines; Radioimmunoassay; Receptor, Muscarinic M2; Respiratory System	2009
Characterization of the effect of penehyclidine hydrochloride on muscarinic receptor subtypes mediating the contraction of guinea-pig isolated gastrointestinal smooth muscle. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:7 Topics: Acetylcholine; Animals; Atropine; Cyclic AMP; Dose-Response Relationship, Drug; Female; Gastrointestinal Tract; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Quinuclidines; Radioligand Assay; Receptor, Muscarinic M2; Receptor, Muscarinic M3	2009
Underlying mechanism of penehyclidine hydrochloride on isolated rat uterus. Fundamental & clinical pharmacology, 2009, Volume: 23, Issue:4 Topics: Animals; Cholinergic Antagonists; Cyclic AMP; Female; In Vitro Techniques; Quinuclidines; Radioimmunoassay; Rats; Receptor, Muscarinic M2; Receptors, Muscarinic	2009
[The effect of penehyclidine hydrochloride on the expression of inflammatory factor in rat with sepsis-associated lung injury]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2009, Volume: 21, Issue:11 Topics: Animals; Disease Models, Animal; HMGB1 Protein; Lung; Lung Injury; Male; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley; Sepsis	2009
Effects of penehyclidine hydrochloride on apoptosis of lung tissues in rats with traumatic acute lung injury. Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2010, Volume: 13, Issue:1 Topics: Acute Lung Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Lung; Male; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Rats; Rats, Sprague-Dawley; Thoracic Injuries; Wounds, Nonpenetrating	2010
[Effect of ketamine combined with penehyclidine hydrochloride on the expression of synaptophysin in the brain of neonatal rats]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2010, Volume: 12, Issue:1 Topics: Animals; Animals, Newborn; Cholinergic Antagonists; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Hippocampus; Ketamine; Maze Learning; Memory; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptophysin	2010
[Detecting penehyclidine hydrochloride in rats plasma and tissues with HPLC-MS/MS]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010, Volume: 41, Issue:1 Topics: Animals; Chromatography, High Pressure Liquid; Quinuclidines; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution	2010
[Effect of penehyclidine hydrochloride on tumor necrosis factor-alpha in liver and spleen in mice with acute organophosphorus pesticide poisoning]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2010, Volume: 22, Issue:4 Topics: Acute Disease; Animals; Disease Models, Animal; Liver; Male; Mice; Mice, Inbred BALB C; Organophosphate Poisoning; Poisoning; Quinuclidines; RNA, Messenger; Spleen; Tumor Necrosis Factor-alpha	2010
Protective effects of penehyclidine hydrochloride on liver injury in a rat cardiopulmonary bypass model. European journal of anaesthesiology, 2010, Volume: 27, Issue:9 Topics: Alanine Transaminase; Anesthesiology; Animals; Aspartate Aminotransferases; Cardiopulmonary Bypass; Femoral Artery; Heart Rate; Inflammation; Liver; Male; Microscopy, Electron; Postoperative Period; Quinuclidines; Rats; Rats, Sprague-Dawley; Ultrasonography	2010
Effect of penehyclidine hydrochloride on expressions of MAPK in mice with CLP-induced acute lung injury. Molecular biology reports, 2011, Volume: 38, Issue:3 Topics: Acute Lung Injury; Animals; Capillary Permeability; Cecum; Extracellular Signal-Regulated MAP Kinases; Female; Interleukin-6; JNK Mitogen-Activated Protein Kinases; Ligation; Lung; Mice; Microvessels; Mitogen-Activated Protein Kinases; Oxygen; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Punctures; Quinuclidines	2011
[Experimental therapy of penehyclidine hydrochloride on paraquat-induced acute lung injury]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2010, Volume: 28, Issue:9 Topics: Acute Lung Injury; Animals; Caveolin 1; Endothelins; Hydroxyproline; Male; Matrix Metalloproteinase 2; Paraquat; Quinuclidines; Rats; Rats, Wistar	2010
Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion. World journal of gastroenterology, 2011, Jan-14, Volume: 17, Issue:2 Topics: Animals; Cytokines; Endotoxins; Extremities; Free Radicals; Intestinal Mucosa; Intestine, Small; Male; Microscopy; Oxygen; Quinuclidines; Rats; Rats, Wistar; Reperfusion Injury	2011
Regulated hypoxia/reperfusion-dependent modulation of ERK1/2, cPLA2, and Bcl-2/Bax: a potential mechanism of neuroprotective effect of penehyclidine hydrochloride. The International journal of neuroscience, 2011, Volume: 121, Issue:8 Topics: Analysis of Variance; Animals; bcl-2-Associated X Protein; Caspase 3; Cyclopentanes; Down-Regulation; Hippocampus; Hypoxia; In Vitro Techniques; Male; MAP Kinase Signaling System; Neuroprostanes; Phospholipases A2, Cytosolic; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion	2011
Effects of penehyclidine hydrochloride on rat intestinal barrier function during cardiopulmonary bypass. World journal of gastroenterology, 2011, Apr-28, Volume: 17, Issue:16 Topics: Animals; Cardiopulmonary Bypass; Humans; Intestinal Mucosa; Male; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley	2011
[Protective effects of penehyclidine hydrochloride against acute renal injury induced by hemorrhagic shock and lipopolysaccharides in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2011, Volume: 31, Issue:5 Topics: Acute Kidney Injury; Animals; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-8; Kidney; Kidney Tubules; Lipopolysaccharides; Male; NF-kappa B; Quinuclidines; Rats; Rats, Wistar; Shock, Hemorrhagic; Tumor Necrosis Factor-alpha	2011
Penehyclidine hydrochloride attenuates LPS-induced iNOS production by inhibiting p38 MAPK activation in endothelial cells. Molecular biology reports, 2012, Volume: 39, Issue:2 Topics: Analysis of Variance; Blotting, Western; Endothelial Cells; Enzyme Activation; Humans; Imidazoles; Lipopolysaccharides; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinuclidines	2012
[Preventive effects of ischemic postconditioning and penehyclidine hydrochloride on gastric against ischemia-reperfusion injury in rats]. Zhonghua yi xue za zhi, 2011, Apr-26, Volume: 91, Issue:16 Topics: Animals; Disease Models, Animal; Gastric Mucosa; Ischemia; Ischemic Postconditioning; Male; Quinuclidines; Rats; Rats, Wistar; Reperfusion Injury; Stomach Diseases	2011
Effects of early administration of a novel anticholinergic drug on acute respiratory distress syndrome induced by sepsis. Medical science monitor : international medical journal of experimental and clinical research, 2011, Volume: 17, Issue:11 Topics: Animals; Bronchoalveolar Lavage Fluid; Cholinergic Antagonists; Injections, Intraperitoneal; Interleukin-6; Malondialdehyde; Nitrates; Nitrites; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Statistics, Nonparametric; Superoxide Dismutase; Survival Analysis; Tumor Necrosis Factor-alpha	2011
Effects of penehyclidine hydrochloride on pulmonary contusion from blunt chest trauma in rats. Injury, 2012, Volume: 43, Issue:2 Topics: Animals; Anti-Inflammatory Agents; Contusions; Enzyme-Linked Immunosorbent Assay; Immunity, Innate; Immunohistochemistry; Interleukin-6; Lung Injury; Male; Peroxidase; Protective Agents; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley; Thoracic Injuries; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Wounds, Nonpenetrating	2012
[Protection of penehyclidine hydrochloride on renal tissue injury induced by limb ischemia/reperfusion]. Zhonghua yi xue za zhi, 2011, Jul-12, Volume: 91, Issue:26 Topics: Animals; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Quinuclidines; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury	2011
[Penehyclidine hydrochloride inhibits glutamate release and related research in global brain ischemia/reperfusion rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2011, Volume: 27, Issue:3 Topics: Animals; Brain Ischemia; CA1 Region, Hippocampal; Cholinergic Antagonists; Glutamic Acid; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury	2011
Preventive and therapeutic effects of penehyclidine hydrochloride on morphine-induced increased bladder pressure, urinary bladder sphincter pressure and histological damage in rabbits. Chinese medical journal, 2012, Volume: 125, Issue:6 Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Hemodynamics; Male; Morphine; Pressure; Quinuclidines; Rabbits; Urinary Bladder; Urinary Retention	2012
[Clinical study of effect of penehyclidine hydrochloride and atropine sequential therapy in the treatment of severe acute organophosphorus pesticide poisoning]. Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue, 2012, Volume: 24, Issue:6 Topics: Adolescent; Adult; Aged; Atropine; Female; Humans; Male; Middle Aged; Organophosphate Poisoning; Quinuclidines; Retrospective Studies; Young Adult	2012
Penehcyclidine and awareness during anaesthesia: caution with zero numerators. Anaesthesia, 2013, Volume: 68, Issue:2 Topics: Anesthesia, General; Breast Neoplasms; Cholinergic Antagonists; Female; Humans; Intraoperative Awareness; Quinuclidines	2013
A selective M1 and M3 receptor antagonist, penehyclidine hydrochloride, prevents postischemic LTP: involvement of NMDA receptors. Synapse (New York, N.Y.), 2013, Volume: 67, Issue:12 Topics: Animals; Brain Ischemia; Hippocampus; Long-Term Potentiation; Male; Neuroprotective Agents; Potassium Channel Blockers; Protein Kinase C; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Receptors, N-Methyl-D-Aspartate; Scopolamine; Small-Conductance Calcium-Activated Potassium Channels	2013
Penehyclidine hydrochloride attenuates the cerebral injury in a rat model of cardiopulmonary bypass. Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:7 Topics: Animals; Apoptosis; Brain Injuries; Cardiopulmonary Bypass; Caspase 3; Cerebrum; Female; Hemodynamics; Hippocampus; Inflammation; Interleukin-10; Male; Matrix Metalloproteinase 9; p38 Mitogen-Activated Protein Kinases; Phosphopyruvate Hydratase; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Rats; Rats, Sprague-Dawley; RNA, Messenger; S100 Calcium Binding Protein beta Subunit	2013
Penehyclidine hydrochloride protects against oxygen and glucose deprivation injury by modulating amino acid neurotransmitters release. Neurological research, 2013, Volume: 35, Issue:10 Topics: Amino Acids; Animals; Glucose; Glutamic Acid; Hippocampus; Ischemia; Male; Neurons; Oxygen; Quinuclidines; Rats; Rats, Sprague-Dawley	2013
Penehyclidine hydrochloride ameliorates renal ischemia-reperfusion injury in rats. The Journal of surgical research, 2014, Volume: 186, Issue:1 Topics: Animals; Caspase 3; Cholinergic Antagonists; Kidney; Male; Malondialdehyde; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Superoxide Dismutase; Transcription Factor RelA	2014
Penehyclidine hydrochloride inhibits the release of high-mobility group box 1 in lipopolysaccharide-activated RAW264.7 cells and cecal ligation and puncture-induced septic mice. The Journal of surgical research, 2014, Volume: 186, Issue:1 Topics: Animals; Apoptosis; Cecum; Cell Survival; Cells, Cultured; Cholinergic Antagonists; HMGB1 Protein; Ligation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Protein Transport; Quinuclidines; Sepsis	2014
Protective effects of penehyclidine hydrochloride on acute lung injury caused by severe dichlorvos poisoning in swine. Chinese medical journal, 2013, Volume: 126, Issue:24 Topics: Acute Lung Injury; Animals; Dichlorvos; Female; Quinuclidines; Swine	2013
Protective effect of penehvclidine hvdrochloride on ischemia-reperfusion injury in rats. Asian Pacific journal of tropical medicine, 2014, Volume: 7, Issue:1 Topics: Animals; Cytokines; Female; Inflammation; Kidney; Oxidative Stress; Protective Agents; Quinuclidines; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reperfusion Injury	2014
Penehyclidine hydrochloride inhibits the LPS-induced inflammatory response in microglia. The Journal of surgical research, 2014, May-01, Volume: 188, Issue:1 Topics: Animals; Cell Survival; Cells, Cultured; Dinoprostone; Drug Evaluation, Preclinical; Inflammation; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Quinuclidines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha	2014
Penehyclidine hydrochloride decreases pulmonary microvascular permeability by upregulating beta arrestins in a murine cecal ligation and puncture model. The Journal of surgical research, 2015, Volume: 193, Issue:1 Topics: Acute Lung Injury; Animals; Arrestins; beta-Arrestins; Capillary Permeability; Cecum; Cholinergic Antagonists; Disease Models, Animal; Female; Ligation; Lung; Mice, Inbred Strains; Microcirculation; NF-kappa B; Pulmonary Circulation; Quinuclidines; Random Allocation; Up-Regulation; Wounds, Stab	2015
Penehyclidine hydrochloride postconditioning on lipopolysaccharide-induced acute lung injury by inhibition of inflammatory factors in a rodent model. The Journal of surgical research, 2015, May-01, Volume: 195, Issue:1 Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Interleukin-6; Lipopolysaccharides; Lung; Male; NF-kappa B; Peroxidase; Pulmonary Gas Exchange; Quinuclidines; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha	2015
Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat. Genetics and molecular research : GMR, 2015, Aug-10, Volume: 14, Issue:3 Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Creatinine; Cytokines; Disease Models, Animal; Kidney; Lipopolysaccharides; Male; Occludin; Protective Agents; Quinuclidines; Rats; Zonula Occludens-1 Protein	2015
Penehyclidine Hydrochloride Preconditioning Provides Cardioprotection in a Rat Model of Myocardial Ischemia/Reperfusion Injury. PloS one, 2015, Volume: 10, Issue:12 Topics: Animals; Apoptosis; Cardiotonic Agents; Cytokines; Disease Models, Animal; Inflammation Mediators; Ischemic Preconditioning; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxidative Stress; Quinuclidines; Rats; Rats, Wistar	2015
Neuroprotective effects of penehyclidine hydrochloride against cerebral ischemia/reperfusion injury in mice. Brain research bulletin, 2016, Volume: 121 Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Edema; Brain Infarction; Capillary Permeability; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione Peroxidase; In Situ Nick-End Labeling; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Neurologic Examination; Neuroprotective Agents; Quinuclidines; Reperfusion Injury; Superoxide Dismutase; Time Factors	2016
Penehyclidine Hydrochloride Pretreatment Ameliorates Rhabdomyolysis-Induced AKI by Activating the Nrf2/HO-1 Pathway and Alleviating [corrected] Endoplasmic Reticulum Stress in Rats. The. PloS one, 2016, Volume: 11, Issue:3 Topics: Acute Kidney Injury; Animals; Cholinergic Antagonists; Endoplasmic Reticulum Stress; Heme Oxygenase-1; Kidney; Male; NF-E2-Related Factor 2; Quinuclidines; Rats; Rats, Sprague-Dawley; Rhabdomyolysis; Signal Transduction	2016
[The research on protective effect of penehyclidine hydrochloride in rats with myocardial ischemia/reperfusion injury]. Zhonghua wei zhong bing ji jiu yi xue, 2015, Volume: 27, Issue:12 Topics: Animals; Cardiotonic Agents; Creatine Kinase, MB Form; Furans; L-Lactate Dehydrogenase; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Quinuclidines; Random Allocation; Rats; Rats, Wistar	2015
Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway. European journal of pharmacology, 2017, Feb-15, Volume: 797 Topics: Apoptosis; Calcium; Cell Line; Creatine Kinase; Cytoprotection; Humans; L-Lactate Dehydrogenase; Malondialdehyde; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Membrane Transport Proteins; Myocytes, Cardiac; Oxidation-Reduction; Oxygen; Quinuclidines; Superoxide Dismutase	2017
Cardioprotective time-window of Penehyclidine hydrochloride postconditioning: A rat study. European journal of pharmacology, 2017, Oct-05, Volume: 812 Topics: Animals; Biomarkers; Cardiotonic Agents; Cytokines; Gene Expression Regulation; Hemodynamics; Ischemic Postconditioning; Myocardial Reperfusion Injury; NF-kappa B; NF-KappaB Inhibitor alpha; Oxidative Stress; Quinuclidines; Rats; Rats, Wistar; Time Factors	2017
Penehyclidine hydrochloride preconditioning provides cardiac protection in a rat model of myocardial ischemia/reperfusion injury via the mechanism of mitochondrial dynamics mechanism. European journal of pharmacology, 2017, Oct-15, Volume: 813 Topics: Adenosine Triphosphate; Animals; Apoptosis; Cardiotonic Agents; Disease Models, Animal; Gene Expression Regulation; Heart; Ischemic Preconditioning; Male; Mitochondria; Mitochondrial Dynamics; Myocardial Reperfusion Injury; Oxidative Stress; Quinuclidines; Rats; Rats, Wistar; RNA, Messenger	2017
Curative efficacy of penehyclidine combined with edaravone on acute cerebral infarction and their effects on serum TNF-α and NDS score in rats. European review for medical and pharmacological sciences, 2018, Volume: 22, Issue:1 Topics: Acute Disease; Animals; Cerebral Infarction; Edaravone; HMGB1 Protein; Interleukin-6; Quinuclidines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha	2018
Penehyclidine hydrochloride inhibits TLR4 signaling and inflammation, and attenuates blunt chest trauma and hemorrhagic shock-induced acute lung injury in rats. Molecular medicine reports, 2018, Volume: 17, Issue:5 Topics: Acute Lung Injury; Animals; Inflammation; Male; MAP Kinase Signaling System; Quinuclidines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Thorax; Toll-Like Receptor 4; Wounds, Nonpenetrating	2018
Regulation of VDAC1 contributes to the cardioprotective effects of penehyclidine hydrochloride during myocardial ischemia/reperfusion. Experimental cell research, 2018, 06-15, Volume: 367, Issue:2 Topics: Animals; Apoptosis; Cardiotonic Agents; Cell Membrane Permeability; Male; Membrane Potential, Mitochondrial; Mitochondria; Myocardial Reperfusion Injury; Myocytes, Cardiac; Quinuclidines; Rats; Rats, Wistar; Voltage-Dependent Anion Channel 1	2018
Penehyclidine Hydrochloride Decreases Pulmonary Microvascular Endothelial Inflammatory Injury Through a Beta-Arrestin-1-Dependent Mechanism. Inflammation, 2018, Volume: 41, Issue:5 Topics: beta-Arrestin 1; Cells, Cultured; Endothelial Cells; Humans; Inflammation; Lipopolysaccharides; Lung Injury; Microvessels; NF-kappa B; Quinuclidines; Up-Regulation	2018
Effects of penehyclidine hydrochloride on severe acute pancreatitis-associated acute lung injury in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 97 Topics: Acute Disease; Acute Lung Injury; Animals; Hypoxia-Inducible Factor 1, alpha Subunit; Interleukin-1beta; Interleukin-6; Lung; Male; Pancreas; Pancreatitis; Quinuclidines; Rats, Sprague-Dawley; Toll-Like Receptor 4; Transcription Factor RelA	2018
Penehyclidine hydrochloride regulates mitochondrial dynamics and apoptosis through p38MAPK and JNK signal pathways and provides cardioprotection in rats with myocardial ischemia-reperfusion injury. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2018, 08-30, Volume: 121 Topics: Animals; Apoptosis; Cardiotonic Agents; Male; MAP Kinase Signaling System; Mitochondrial Dynamics; Myocardial Reperfusion Injury; Quinuclidines; Rats, Wistar	2018
Penehyclidine hydrochloride preconditioning provides pulmonary and systemic protection in a rat model of lung ischaemia reperfusion injury. European journal of pharmacology, 2018, Nov-15, Volume: 839 Topics: Animals; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation; Inflammation Mediators; Ischemic Preconditioning; Lung; Male; NF-kappa B; Oxidative Stress; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury	2018
Mechanism of penehyclidine hydrochloride on a dysmenorrhea rat model. Drug development research, 2019, Volume: 80, Issue:3 Topics: Animals; Behavior, Animal; Calcium; Disease Models, Animal; Dysmenorrhea; Estradiol; Female; Oxytocin; Pain; Quinuclidines; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Toll-Like Receptor 3; Toll-Like Receptor 4; Uterus	2019
Penehyclidine effects the angiogenic potential of pulmonary microvascular endothelial cells. Pulmonary pharmacology & therapeutics, 2019, Volume: 55 Topics: Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Cholinergic Antagonists; Chromones; Endothelial Cells; Endothelium, Vascular; Lung; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Quinuclidines; Rats; TOR Serine-Threonine Kinases	2019
Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute lung injury in rats: Potential role of caveolin‑1 expression upregulation. International journal of molecular medicine, 2019, Volume: 43, Issue:5 Topics: Acute Lung Injury; Animals; Blood Gas Analysis; Capillary Permeability; Caveolin 1; Cell Line; Cytokines; Inflammation Mediators; Lipopolysaccharides; Lung; Male; Mice; Peroxidase; Pneumonia; Quinuclidines; Rats, Sprague-Dawley; Up-Regulation	2019
Roles of M Journal of receptor and signal transduction research, 2019, Volume: 39, Issue:1 Topics: Actins; beta-Arrestin 1; Cells, Cultured; Endothelium, Vascular; Gene Expression Regulation; Humans; Lipopolysaccharides; Pulmonary Artery; Quinuclidines; Receptor, Muscarinic M3	2019
Penehyclidine Hydrochloride Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Ameliorating Apoptosis and Endoplasmic Reticulum Stress. The Journal of surgical research, 2020, Volume: 245 Topics: Acute Lung Injury; Animals; Apoptosis; Drug Evaluation, Preclinical; Endoplasmic Reticulum Stress; Glutathione Peroxidase; Lipopolysaccharides; Lung; Male; Malondialdehyde; Peroxidase; Quinuclidines; Random Allocation; Rats, Sprague-Dawley; Superoxide Dismutase	2020
Penehyclidine hydrochloride defends against LPS-induced ALI in rats by mitigating endoplasmic reticulum stress and promoting the Hes1/Notch1 pathway. Gene, 2019, Dec-30, Volume: 721 Topics: Acute Lung Injury; Animals; Apoptosis; Dose-Response Relationship, Drug; Down-Regulation; Endoplasmic Reticulum Stress; Hyaluronan Synthases; Lipopolysaccharides; Macrophages, Alveolar; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction	2019
Smoking Attenuates Efficacy of Penehyclidine Hydrochloride in Acute Respiratory Distress Syndrome Induced by Lipopolysaccharide in Rats. Medical science monitor : international medical journal of experimental and clinical research, 2019, Sep-28, Volume: 25 Topics: Animals; Blood Gas Analysis; Cigarette Smoking; Disease Models, Animal; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Signal Transduction; Treatment Outcome	2019
A Selective M Neurochemical research, 2019, Volume: 44, Issue:12 Topics: Animals; Antidepressive Agents; Astrocytes; Brain-Derived Neurotrophic Factor; Depression; Hindlimb Suspension; Hippocampus; Male; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroglia; Quinuclidines; Receptor, Muscarinic M1; Receptor, Muscarinic M3; Stress, Psychological; Swimming	2019
Postconditioning Protection Against Myocardiocyte Anoxia/Reoxygenation Injury From Penehyclidine Hydrochloride. Drug design, development and therapy, 2019, Volume: 13 Topics: Apoptosis; Cell Line; Humans; Hypoxia; Myocardial Reperfusion Injury; Myocytes, Cardiac; Protective Agents; Quinuclidines	2019
Prevention of renal ischemia and reperfusion injury by penehyclidine hydrochloride through autophagy activation. Molecular medicine reports, 2020, Volume: 21, Issue:5 Topics: Adenine; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransferases; Autophagy; Beclin-1; Caspase 3; Cell Proliferation; Disease Models, Animal; Ischemia; Kidney; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sirolimus	2020
Penehyclidine hydrochloride inhibits renal ischemia/reperfusion-induced acute lung injury by activating the Nrf2 pathway. Aging, 2020, 07-11, Volume: 12, Issue:13 Topics: Acute Lung Injury; Animals; Apoptosis; Disease Models, Animal; Gene Knockout Techniques; Humans; Kidney; Kidney Diseases; Lung; Macrophages, Alveolar; Male; NF-E2-Related Factor 2; Oxidative Stress; Quassins; Quinuclidines; Rats; Rats, Transgenic; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; tert-Butylhydroperoxide	2020
Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway. Molecular medicine reports, 2021, Volume: 23, Issue:2 Topics: Animals; Autophagy; Cell Line; Humans; Lipopolysaccharides; Male; Quinuclidines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Signal Transduction	2021
Tumor necrosis factor α‑induced protein 8‑like 2 contributes to penehyclidine hydrochloride pretreatment against lipopolysaccharide‑induced acute lung injury in a mouse model. Molecular medicine reports, 2021, Volume: 24, Issue:5 Topics: Acute Lung Injury; Animals; Apoptosis; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Lung; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Quinuclidines; Transcription Factor RelA; Tumor Necrosis Factor-alpha	2021
Penehyclidine hydrochloride suppresses inflammation response and reduces podocyte injury in diabetic nephropathy by targeting fibrinogen-like protein 2. International immunopharmacology, 2022, Volume: 107 Topics: Animals; Caspase 1; Diabetes Mellitus; Diabetic Nephropathies; Female; Fibrinogen; Humans; Inflammation; Male; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Podocytes; Quinuclidines; Rats; Toll-Like Receptor 4	2022
Effect of penehyclidine hydrochloride on inflammatory response and oxidative stress in rats with cardiopulmonary bypass related-lung injury. Acta cirurgica brasileira, 2022, Volume: 37, Issue:4 Topics: Acute Lung Injury; Animals; Cardiopulmonary Bypass; Lung; Oxidative Stress; Quinuclidines; Rats; Rats, Sprague-Dawley; Water	2022