quinuclidines has been researched along with chir-124 in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Aardalen, K; Cheema, H; Embry, M; Gesner, TG; Hibner, B; Lopes de Menezes, DE; Ma, S; Moler, EJ; Ni, ZJ; Rendahl, KG; Schwartz, GK; Sheikh, T; Tse, AN | 1 |
| Bourhis, J; Castedo, M; Deutsch, E; Golsteyn, RM; Kroemer, G; Leteur, C; Pierré, A; Tao, Y; Yang, C; Zhang, P | 1 |
| Choy, ML; Lee, JH; Marks, PA; Ngo, L; Venta-Perez, G | 1 |
| Ausseil, F; Cordelier, P; Dedieu, L; Ducommun, B; Dufau, I; Frongia, C; Sicard, F; Valette, A | 1 |
| Ahmad, H; Boghozian, RA; Gill, MR; Halder, S; Harun, SN; Ramadan, K; Vallis, KA | 1 |
| Biskup, E; Gniadecki, R; Naym, DG | 1 |
| Afreen, S; Erlacher, M; Häcker, G; Manzl, C; Schuler, F; Villunger, A | 1 |
| Faisal, A; Furqan, M; Mithani, A; Saleem, RSZ; Ullah, R; Zahra, R | 1 |
| Hu, J; Jiang, J; Liu, H; Qing, G; Song, X; Su, H; Tu, R; Wang, J; Wang, L; Wang, T | 1 |
9 other study(ies) available for quinuclidines and chir-124
| Article | Year |
|---|---|
CHIR-124, a novel potent inhibitor of Chk1, potentiates the cytotoxicity of topoisomerase I poisons in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Checkpoint Kinase 1; Drug Synergism; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Mice; Mice, SCID; Models, Chemical; Neoplasm Transplantation; Protein Kinases; Quinolines; Quinuclidines; Random Allocation; Topoisomerase I Inhibitors | 2007 |
Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints.
Topics: 14-3-3 Proteins; Animals; Calcium-Binding Proteins; Cell Cycle; Cell Cycle Proteins; Cell Survival; Checkpoint Kinase 1; DNA Damage; Enzyme Activation; Flow Cytometry; G2 Phase; HCT116 Cells; Humans; Immunohistochemistry; Mad2 Proteins; Mice; Mitotic Index; Polyploidy; Protein Kinases; Quinolines; Quinuclidines; Radiation-Sensitizing Agents; Radiation, Ionizing; Repressor Proteins; Spindle Apparatus; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2009 |
Role of checkpoint kinase 1 (Chk1) in the mechanisms of resistance to histone deacetylase inhibitors.
Topics: Animals; Cell Line, Tumor; Cell Survival; Cells, Cultured; Checkpoint Kinase 1; DNA Damage; Drug Resistance; Fibroblasts; Foreskin; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Male; Mice; Protein Kinases; Quinolines; Quinuclidines; RNA Interference; Spleen; Staurosporine; Thiophenes; Urea; Vorinostat | 2011 |
Multicellular tumor spheroid model to evaluate spatio-temporal dynamics effect of chemotherapeutics: application to the gemcitabine/CHK1 inhibitor combination in pancreatic cancer.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Proliferation; Deoxycytidine; DNA Damage; Drug Resistance, Neoplasm; Gemcitabine; Humans; Models, Biological; Pancreatic Neoplasms; Protein Kinase Inhibitors; Quinolines; Quinuclidines; Spheroids, Cellular; Tumor Cells, Cultured; Tumor Microenvironment | 2012 |
A ruthenium polypyridyl intercalator stalls DNA replication forks, radiosensitizes human cancer cells and is enhanced by Chk1 inhibition.
Topics: Animals; Apoptosis; BRCA1 Protein; Cattle; Cell Line; Cell Proliferation; Checkpoint Kinase 1; Coordination Complexes; DNA; DNA Damage; DNA Repair; DNA Replication; G1 Phase Cell Cycle Checkpoints; Gene Expression; HeLa Cells; Histones; Humans; Intercalating Agents; Phosphorylation; Quinolines; Quinuclidines; Radiation-Sensitizing Agents; Radiation, Ionizing; Ruthenium | 2016 |
Small-molecule inhibitors of Ataxia Telangiectasia and Rad3 related kinase (ATR) sensitize lymphoma cells to UVA radiation.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Checkpoint Kinase 1; Flow Cytometry; Histones; Humans; Isoxazoles; Lymphoma, T-Cell, Cutaneous; Phosphorylation; Photochemotherapy; Photosensitizing Agents; Pyrazines; Quinolines; Quinuclidines; RNA, Small Interfering; Sulfones; Tumor Cells, Cultured; Ultraviolet Rays | 2016 |
Checkpoint kinase 1 is essential for fetal and adult hematopoiesis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzodiazepinones; Bone Marrow Cells; Cell Line, Tumor; Checkpoint Kinase 1; Embryo, Mammalian; Fetus; G2 Phase Cell Cycle Checkpoints; Hematopoiesis; Hematopoietic Stem Cells; Humans; Lymphoma; Melanoma, Experimental; Mice; Mice, Knockout; Primary Cell Culture; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Quinolines; Quinuclidines; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2019 |
A cell-based high-throughput screen identifies inhibitors that overcome P-glycoprotein (Pgp)-mediated multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brefeldin A; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; High-Throughput Screening Assays; Humans; Hydrazines; Hydrazones; Neoplasms; Quinolines; Quinuclidines; Sulfonamides; Tyrphostins | 2020 |
Synergistic targeting of CHK1 and mTOR in MYC-driven tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Checkpoint Kinase 1; Datasets as Topic; Disease Progression; Drug Synergism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; N-Myc Proto-Oncogene Protein; Neuroblastoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Proto-Oncogene Proteins c-myc; Quinolines; Quinuclidines; Sirolimus; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2021 |