quinuclidines has been researched along with carbamates in 23 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.35) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 3 (13.04) | 29.6817 |
| 2010's | 15 (65.22) | 24.3611 |
| 2020's | 3 (13.04) | 2.80 |
| Authors | Studies |
|---|---|
| Mashkovsky, MD; Yakhontov, LN | 1 |
| Dunaj, S; Primozic, I; Reiner, E; Simeon-Rudolf, V; Skrinjarić-Spoljar, M; Tomić, S | 1 |
| Feuerbach, D; Hoyer, D; Lingenhoehl, K; McAllister, K; Nozulak, J | 1 |
| Bilbe, G; Chaperon, F; Enz, A; Feuerbach, D; Gentsch, C; Hoyer, D; Lingenhoehl, K; McAllister, K; Nozulak, J; Olpe, HR; Vassout, A | 1 |
| Ballarín, M; Balsa, D; Cabellos, J; Davalillo, S; Fernández, A; Lagunas, C; Pérez-Del-Pulgar, S; Salcedo, C | 1 |
| Arias, HR; Feuerbach, D; Gu, RX; Wei, DQ | 1 |
| Amari, G; Bassani, F; Battipaglia, L; Bergamaschi, M; Berti, F; Bolzoni, PT; Cacciani, F; Cenacchi, V; Civelli, M; Delcanale, M; Geppetti, PA; Harrison, S; Mannini, F; Pastore, F; Patacchini, R; Petrillo, P; Razzetti, R; Rizzi, A; Rossoni, G; Santoro, E; Scudellaro, R; Villetti, G; Volta, R; Zaniboni, M | 1 |
| Danielson, UH; de Esch, IJ; de Kloe, GE; Geitmann, M; Irth, H; Källblad, P; Leurs, R; Nahar, T; Retra, K; Smit, AB; van Elk, R; van Muijlwijk-Koezen, JE | 1 |
| Lilja, AM; Marutle, A; Nordberg, A; Porras, O; Storelli, E | 1 |
| Antón, F; Beleta, J; Buil, MA; Cárdenas, A; Casals, G; Castro, J; Córdoba, M; Espinosa, S; Fernández, MD; Ferrer, M; Gavaldà, A; González, M; Huerta, JM; López, M; Miralpeix, M; Monleón, JM; Prat, M; Ramos, I; Ryder, H; Segarra, V; Tort, L; Vilella, D | 1 |
| Kacprzak, KM; Lindner, W | 1 |
| Arias, HR; Bergé, I; Bouzat, C; De Rosa, MJ; Feuerbach, D | 1 |
| Hamaguchi, H; Kontani, T; Koshika, T; Matsushima, Y; Moritomo, A; Nagashima, S; Nagata, H; Takeuchi, M | 1 |
| Ashe, KM; Bangari, DS; Budman, E; Cheng, SH; Desnick, RJ; Leonard, JP; Marshall, J; Nietupski, JB; Scheule, RK; Siegel, CS; Wang, B | 1 |
| Lilja, AM; Malmsten, L; Marutle, A; Nordberg, A; Ögren, SO; Röjdner, J; Verkhratsky, A; Voytenko, L | 1 |
| Annadurai, S; Bencheriff, M; Canney, DJ; Gabriel, JL; Zhang, M | 1 |
| Allaire, A; Bangari, DS; Budman, E; Cheng, SH; Cromwell, MA; Grabowski, GA; Leonard, JP; Marshall, J; Nietupski, JB; Park, H; Sun, Y; Wang, B | 1 |
| Cheng, SH; Clarke, J; Dodge, JC; Makino, E; Marshall, J; Olszewski, MA; Park, H; Richards, AM; Sardi, SP; Shihabuddin, LS; Sidman, RL; Treleaven, CM; Viel, C; Wang, B | 1 |
| Bommagani, S; Dwoskin, LP; Gujarathi, S; Lee, NR; Siripurapu, K; Zheng, G | 1 |
| Bangari, DS; Cao, J; Cheng, SH; Leonard, JP; Marshall, J; Nietupski, JB; Park, H; Randall, K; Silvescu, C; Tietz, D; Wang, B; Wilper, T; Ying, X | 1 |
| Chiang, MSR; Clarke, J; Kayatekin, C; Park, H; Richards, AM; Sardi, SP; Shihabuddin, LS; Viel, C; Wang, B | 1 |
| Wang, M; Zhang, W; Zhang, Z | 1 |
| Deng, Y; Dong, G; Huang, R; Jain, S; Noinaj, N; Rai, G; Simeonov, A; Talley, D; Yadav, R; Yasgar, A; Zakharov, AV | 1 |
1 review(s) available for quinuclidines and carbamates
| Article | Year |
|---|---|
Relationships between the chemical structure and pharmacological activity in a series of synthetic quinuclidine derivatives.
Topics: Animals; Benactyzine; Carbamates; Cats; Chemical Phenomena; Chemistry; Esters; Ganglionic Blockers; Iodides; Mice; Parasympatholytics; Pilocarpine; Piperidines; Prochlorperazine; Pupil; Quinuclidines; Rabbits; Rats; Salicylates; Tubocurarine | 1969 |
22 other study(ies) available for quinuclidines and carbamates
| Article | Year |
|---|---|
3-Hydroxyquinuclidinium derivatives: synthesis of compounds and inhibition of acetylcholinesterase.
Topics: Acetylcholinesterase; Acetylthiocholine; Carbamates; Cholinesterase Inhibitors; Drug Stability; Erythrocytes; Humans; Imidazoles; Kinetics; Oximes; Quinuclidines; Solutions; Water | 1999 |
JN403, in vitro characterization of a novel nicotinic acetylcholine receptor alpha7 selective agonist.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Bungarotoxins; Calcium; Carbamates; Humans; In Vitro Techniques; Iodine Radioisotopes; Membrane Potentials; Nicotinic Agonists; Oocytes; Patch-Clamp Techniques; Quinuclidines; Radioligand Assay; Receptors, Nicotinic; Recombinant Proteins; Xenopus | 2007 |
The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.
Topics: Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Carbamates; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Epilepsy; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Male; Mice; Mice, Inbred DBA; Nicotine; Nicotinic Agonists; Pain; Pain Threshold; Quinuclidines; Rats; Receptors, Nicotinic; Sensory Gating; Social Behavior; Time Factors | 2009 |
In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder.
Topics: Animals; Atrial Function; Benzhydryl Compounds; Benzofurans; Carbamates; Cresols; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Phenylpropanolamine; Pyrrolidines; Quinuclidines; Receptor, Muscarinic M3; Solifenacin Succinate; Tetrahydroisoquinolines; Tolterodine Tartrate; Urinary Bladder | 2009 |
Different interaction between the agonist JN403 and the competitive antagonist methyllycaconitine with the human alpha7 nicotinic acetylcholine receptor.
Topics: Aconitine; alpha7 Nicotinic Acetylcholine Receptor; Binding Sites; Carbamates; Cells, Cultured; Humans; Hydrogen Bonding; Kinetics; Ligands; Models, Molecular; Nicotinic Agonists; Nicotinic Antagonists; Protein Conformation; Quinuclidines; Receptors, Nicotinic; Thermodynamics | 2010 |
Bronchodilator activity of (3R)-3-[[[(3-fluorophenyl)[(3,4,5-trifluorophenyl)methyl]amino] carbonyl]oxy]-1-[2-oxo-2-(2-thienyl)ethyl]-1-azoniabicyclo[2.2.2]octane bromide (CHF5407), a potent, long-acting, and selective muscarinic M3 receptor antagonist.
Topics: Acetylcholine; Aged; Anesthesia; Animals; Blood Pressure; Bronchi; Bronchial Spasm; Bronchoconstriction; Bronchoconstrictor Agents; Bronchodilator Agents; Carbachol; Carbamates; CHO Cells; Cricetinae; Cricetulus; Diamines; Guinea Pigs; Heart Atria; Heart Rate; Humans; Kinetics; Male; Middle Aged; Molecular Structure; Muscarinic Antagonists; Myocardial Contraction; Quinuclidines; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Scopolamine Derivatives; Tiotropium Bromide; Trachea; Transfection; Ventricular Function, Left | 2010 |
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.
Topics: Animals; Aplysia; Binding Sites; Binding, Competitive; Biosensing Techniques; Carbamates; Carrier Proteins; Humans; Ligands; Lymnaea; Models, Molecular; Pyridines; Quinuclidines; Radioligand Assay; Receptors, Nicotinic; Structure-Activity Relationship; Surface Plasmon Resonance | 2010 |
Functional interactions of fibrillar and oligomeric amyloid-β with alpha7 nicotinic receptors in Alzheimer's disease.
Topics: Aged; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzazepines; Carbamates; Cell Line, Tumor; Cells, Cultured; Frontal Lobe; Humans; Neurons; Nicotinic Agonists; PC12 Cells; Quinoxalines; Quinuclidines; Rats; Receptors, Nicotinic; Varenicline | 2011 |
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Topics: Carbamates; Drug Discovery; Humans; Inhibitory Concentration 50; Microsomes, Liver; Molecular Structure; Muscarinic Antagonists; Quaternary Ammonium Compounds; Quinuclidines; Time Factors | 2011 |
Novel Pirkle-type quinine 3,5-dinitrophenylcarbamate chiral stationary phase implementing click chemistry.
Topics: Carbamates; Chromatography, High Pressure Liquid; Click Chemistry; Cyclization; Gels; Molecular Structure; Quinolines; Quinuclidines; Silicon Dioxide; Stereoisomerism | 2011 |
Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium Signaling; Carbamates; Cell Line; Fetal Proteins; Humans; Kinetics; Membrane Potentials; Mice; Molecular Conformation; Molecular Docking Simulation; Muscle Proteins; Nerve Tissue Proteins; Nicotinic Agonists; Nicotinic Antagonists; Protein Binding; Protein Subunits; Quinuclidines; Receptors, Nicotinic; Recombinant Proteins; Torpedo | 2013 |
Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists.
Topics: Animals; Carbamates; Dose-Response Relationship, Drug; Male; Models, Molecular; Molecular Structure; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Structure-Activity Relationship | 2014 |
Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease.
Topics: alpha-Galactosidase; Animals; Blood-Brain Barrier; Carbamates; Disease Models, Animal; Fabry Disease; Glucosyltransferases; Glycolipids; Humans; Mice; Quinuclidines; Sphingolipids; Trihexosylceramides | 2015 |
Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic α7 Nicotinic Receptor Drugs.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Carbamates; Cell Proliferation; Cognition; Doublecortin Protein; Female; Hippocampus; Humans; Male; Maze Learning; Memory; Mice; Nerve Regeneration; Neural Stem Cells; Neurogenesis; Nicotinic Agonists; Physostigmine; Quinuclidines; Stem Cell Transplantation | 2015 |
Ether and Carbamate Derivatives of 3-quinuclidinol and 3- hydroxymethylquinuclidine: Synthesis and Evaluation as Nicotinic Ligands.
Topics: Acetylcholine; Animals; Carbamates; Drug Partial Agonism; Ethers; Female; Humans; Ligands; Models, Molecular; Neurotransmitter Agents; Nicotinic Agonists; PC12 Cells; Quinuclidines; Rats; Rats, Sprague-Dawley; Synaptosomes | 2016 |
CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease.
Topics: Administration, Oral; Animals; Carbamates; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Gaucher Disease; Glucosyltransferases; Glycolipids; Humans; Inositol; Liver; Lysosomes; Mice; Quinuclidines; Tissue Distribution; Treatment Outcome | 2016 |
Glucosylceramide synthase inhibition alleviates aberrations in synucleinopathy models.
Topics: alpha-Synuclein; Animals; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Gene Expression Regulation; Glucosyltransferases; Humans; Mice; Mutation; Parkinson Disease; Protein Aggregation, Pathological; Quinuclidines; tau Proteins; Ubiquitin | 2017 |
Muscarinic agonist, (±)-quinuclidin-3-yl-(4-fluorophenethyl)(phenyl)carbamate: High affinity, but low subtype selectivity for human M
Topics: Animals; Carbamates; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Humans; Ligands; Molecular Structure; Muscarinic Agonists; Quinuclidines; Rats; Receptors, Muscarinic; Structure-Activity Relationship | 2019 |
Substrate Reduction Therapy for Sandhoff Disease through Inhibition of Glucosylceramide Synthase Activity.
Topics: Animals; beta-Hexosaminidase beta Chain; Brain; Carbamates; Disease Models, Animal; Enzyme Inhibitors; Female; Glucosyltransferases; Ligands; Liver; Male; Mass Spectrometry; Mice; Mice, Knockout; Molecular Imaging; Quinuclidines; Receptors, GABA; Sandhoff Disease; Sphingolipids | 2019 |
Preclinical pharmacology of glucosylceramide synthase inhibitor venglustat in a GBA-related synucleinopathy model.
Topics: Animals; Carbamates; Disease Models, Animal; Glucosylceramidase; Glucosylceramides; Glucosyltransferases; Hippocampus; Mice; Mice, Inbred C57BL; Mutation; Parkinson Disease; Quinuclidines; Synucleinopathies | 2021 |
Design, Synthesis, and Application of Chiral Bicyclic Imidazole Catalysts.
Topics: Acrolein; Amidines; Amines; Benzofurans; Carbamates; Catalysis; Imidazoles; Lactams; Lewis Bases; Oxindoles; Pyridines; Quinuclidines; Stereoisomerism | 2022 |
Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.
Topics: Carbamates; Ceramides; Enzyme Inhibitors; Glycosyltransferases; Methylation; Methyltransferases; Quinuclidines | 2022 |