quinuclidines and apr-246

Topics: Antineoplastic Agents; Disease-Free Survival; Female; Humans; Male; Molecular Targeted Therapy; Mutation; Neoplasms; Patient Safety; Quinuclidines; Risk Assessment; Sensitivity and Specificity; Signal Transduction; Survival Analysis; Treatment Outcome; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Cell Line, Tumor; Genes, p53; Genetic Therapy; Humans; Molecular Targeted Therapy; Mutation; Neoplasms; Quinuclidines; Tumor Suppressor Protein p53

Topics: Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Humans; Neoplasms; Quinuclidines; Tumor Suppressor Protein p53

Topics: Aminoquinolines; Antineoplastic Agents; Cell Cycle Proteins; Humans; Neoplasms; para-Aminobenzoates; Protein Isoforms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Pyrrolidines; Quinuclidines; Thiosemicarbazones; Tumor Suppressor Protein p53

Topics: Allografts; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Cytarabine; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myeloid, Acute; Phenylurea Compounds; Quinuclidines; Sulfonamides

Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Mutation; Myelodysplastic Syndromes; Precision Medicine; Quinuclidines; Sulfonamides; Treatment Outcome; Tumor Suppressor Protein p53

Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Hematologic Neoplasms; Humans; Male; Maximum Tolerated Dose; Middle Aged; Quinuclidines; Treatment Outcome

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Humans; Leukemia, Myeloid, Acute; Middle Aged; Mutation; Myelodysplastic Syndromes; Quinuclidines; Tumor Suppressor Protein p53

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Humans; Middle Aged; Neoplasms; Quinuclidines

Topics: Adenocarcinoma; Animals; Apoptosis; Aza Compounds; Bone Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Non-Small-Cell Lung; Cisplatin; Drug Interactions; Drug Resistance, Neoplasm; Genes, p53; Humans; Lung Neoplasms; Mice; Mice, SCID; Mutation; Osteosarcoma; Quinuclidines; Transplantation, Heterologous; Tumor Cells, Cultured

Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Caspase 2; Caspase 3; Caspase 9; Caspase Inhibitors; Cytochromes c; Drug Evaluation, Preclinical; Enzyme Activation; Enzyme Inhibitors; Genes, p53; Humans; Membrane Potential, Mitochondrial; Mitochondria; Quinuclidines; Tissue Distribution; Tumor Cells, Cultured

Topics: Cell Line, Tumor; Cell Nucleolus; Cell Transformation, Viral; Cells, Cultured; Epstein-Barr Virus Nuclear Antigens; Humans; Molecular Chaperones; Quinuclidines; Transfection; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Gene Expression; Humans; Mutation; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Trans-Activators; Transcription Factors; Tumor Protein p73; Tumor Suppressor Proteins

Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Combined Modality Therapy; Drug Screening Assays, Antitumor; Female; Furans; Genetic Therapy; Head and Neck Neoplasms; Humans; Imidazoles; Male; Piperazines; Pyrimidines; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Apoptotic Protease-Activating Factor 1; Caspase 3; Caspase 9; Cell Culture Techniques; Cell Line, Tumor; Humans; Melanoma; Mice; Mice, Nude; Proto-Oncogene Proteins; Quinuclidines; RNA Interference; RNA, Small Interfering; Transplantation, Heterologous; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Quinuclidines; RNA Interference; RNA, Small Interfering; Skin Neoplasms; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Humans; Melanoma; Protein Folding; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Progression; Genes, p53; Humans; Lung Neoplasms; Male; Mice; Mice, Nude; Mutant Proteins; Quinuclidines; Small Cell Lung Carcinoma; Time Factors; Xenograft Model Antitumor Assays

Topics: Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genes, p53; Hematologic Neoplasms; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Molecular Targeted Therapy; Patient Safety; Pharmacogenetics; Prospective Studies; Prostatic Neoplasms; Quinuclidines; Risk Factors; Sensitivity and Specificity; Treatment Outcome; Tumor Cells, Cultured

Topics: Adult; Base Sequence; Binding Sites; Cell Differentiation; Cells, Cultured; Cleft Lip; Cleft Palate; Ectodermal Dysplasia; Epidermis; Female; Humans; Keratinocytes; Male; Middle Aged; Models, Biological; Mutant Proteins; Mutation; Quinuclidines; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins

Topics: Binding Sites; Cell Differentiation; Cell Line; Cleft Lip; Cleft Palate; Ectodermal Dysplasia; Epithelial Cells; Epithelium, Corneal; Humans; Induced Pluripotent Stem Cells; Models, Biological; Mutant Proteins; Point Mutation; Quinuclidines; Signal Transduction; Transcription Factors; Tumor Suppressor Proteins

Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Dexamethasone; DNA-Binding Proteins; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Multiple Myeloma; Neoplasms, Experimental; Nuclear Proteins; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Tumor Protein p73; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

Topics: Antineoplastic Agents; Apoptosis; Bone Neoplasms; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Microarray Analysis; Mutation; Quinuclidines; RNA, Small Interfering; Sarcoma, Ewing; Transcriptome; Tumor Cells, Cultured; Tumor Suppressor Protein p53

Topics: Animals; Cell Death; Cell Line, Tumor; Cell Survival; Cytoprotection; Gene Knockdown Techniques; Humans; NADPH Oxidases; Quinuclidines; Rats; Reactive Oxygen Species; RNA, Small Interfering; Thioredoxin Reductase 1

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Death; Cells, Cultured; Female; Glutathione; Humans; Mice; Mice, SCID; Multiple Myeloma; Quinuclidines; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Alkylation; Amifostine; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Evaluation, Preclinical; Ellipticines; Heterocyclic Compounds, 4 or More Rings; Humans; Kinetics; Ligands; Mercaptoethylamines; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutation; Oxepins; Protein Binding; Pyrimidines; Quinuclidines; Tumor Suppressor Protein p53

Topics: Apoptosis; Cell Line, Tumor; Humans; Quinuclidines; Tumor Suppressor Protein p53; Waldenstrom Macroglobulinemia

Topics: Animals; Antineoplastic Agents; Apoptosis; Cells, Cultured; Cisplatin; Deoxycytidine; Docetaxel; Doxorubicin; Drug Resistance, Neoplasm; Enzyme Activation; Female; Gemcitabine; Glutathione; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Protein Folding; Quinuclidines; Random Allocation; Taxoids; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Adenocarcinoma; Animals; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Esophageal Neoplasms; Gene Expression Regulation, Neoplastic; Immunohistochemistry; Mice; Mice, Knockout; Mutation; Neoplasms, Experimental; Quinuclidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Suppressor Protein p53

Topics: Animals; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; HT29 Cells; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Quinuclidines; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Humans; Inhibitory Concentration 50; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Quinuclidines; Reactive Oxygen Species; Sarcoma; Tumor Suppressor Protein p53

Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Case-Control Studies; Cell Proliferation; Combined Modality Therapy; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Hematopoietic Stem Cells; Humans; Immunoenzyme Techniques; Mice; Mice, SCID; MicroRNAs; Multiple Myeloma; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Quinuclidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Synergism; Genetic Predisposition to Disease; Humans; Indoles; Male; Melanoma; Mice, Nude; Molecular Targeted Therapy; Mutation; Phosphatidylinositol 3-Kinase; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Quinuclidines; Signal Transduction; Skin Neoplasms; Sulfonamides; Time Factors; Tumor Suppressor Protein p53; Vemurafenib; Xenograft Model Antitumor Assays

Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Biomarkers; Cell Proliferation; Cell Transdifferentiation; Conjunctiva; Epithelium; Fluorescent Antibody Technique, Indirect; Humans; Keratin-10; Metaplasia; Organ Culture Techniques; Pterygium; Quinuclidines; Real-Time Polymerase Chain Reaction; Transcription Factor 4; Transcription Factors; Tumor Suppressor Proteins; Wnt Signaling Pathway

Topics: Antineoplastic Agents; Apoptosis; BRCA1 Protein; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Quinuclidines; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Poly (ADP-Ribose) Polymerase-1; Proteolysis; Quinuclidines; Reactive Oxygen Species; Tumor Suppressor Protein p53

Topics: Gene Expression Regulation, Leukemic; Heme Oxygenase-1; Humans; Leukemia, Myeloid, Acute; NF-E2-Related Factor 2; Oxidative Stress; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinuclidines; TOR Serine-Threonine Kinases; Tumor Cells, Cultured; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Cell Survival; Cisplatin; Cystadenocarcinoma, Serous; DNA Damage; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Mutation; Neoplasm Grading; Neoplasm Staging; Ovarian Neoplasms; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Antineoplastic Agents; Humans; Mice; MicroRNAs; Mutant Proteins; Mutation, Missense; Neoplasm Metastasis; NF-E2-Related Factor 2; Oligopeptides; Proteasome Endopeptidase Complex; Proteome; Quinuclidines; Triple Negative Breast Neoplasms; Tumor Suppressor Protein p53

Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; DNA Modification Methylases; DNA Repair Enzymes; Extracellular Signal-Regulated MAP Kinases; G2 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mutation; Neoplastic Stem Cells; Nuclear Proteins; Phosphorylation; Quinuclidines; RNA Interference; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

Topics: Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Molecular Targeted Therapy; Mutation; Quinuclidines; Triple Negative Breast Neoplasms; Tumor Suppressor Protein p53

Topics: Animals; Antineoplastic Agents; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; HCT116 Cells; HT29 Cells; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase Kinases; Mice, Nude; Molecular Docking Simulation; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Quinuclidines; Signal Transduction; Time Factors; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Amino Acid Transport System y+; Apoptosis; Cell Line, Tumor; Glutathione; Humans; Lipid Peroxidation; Models, Biological; Mutation; NF-E2-Related Factor 2; Oxidative Stress; Quinuclidines; Reactive Oxygen Species; Stress, Physiological; Tumor Suppressor Protein p53

Topics: Animals; Apoptosis; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Cell Proliferation; Dioxolanes; Drug Therapy, Combination; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Glutathione S-Transferase pi; Head and Neck Neoplasms; Humans; Male; Mice; Mice, SCID; Prognosis; Quinuclidines; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Alkylation; Aminoquinolines; Antineoplastic Agents; Apoptosis; Clinical Trials as Topic; Ellipticines; Humans; Mutation; Neoplasms; Protein Binding; Protein Interaction Domains and Motifs; Pyrazoles; Pyrroles; Quinuclidines; Structure-Activity Relationship; Thiosemicarbazones; Tumor Suppressor Protein p53

Topics: Aminopyridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cleavage And Polyadenylation Specificity Factor; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Female; Humans; Mice; Mice, Nude; Morpholines; Proto-Oncogene Proteins c-akt; Quinuclidines; Signal Transduction; Thyroid Neoplasms; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation

Topics: Antioxidants; Blotting, Western; Cell Line, Tumor; DNA Repair; Glutaredoxins; Humans; Mass Spectrometry; Mitochondria; Oxidation-Reduction; Quinuclidines; Reactive Oxygen Species; Ribonucleotide Reductases; Sulfhydryl Compounds; Thioredoxins

Topics: Amino Acid Transport System y+; Animals; Antineoplastic Agents; Apoptosis; DNA-Binding Proteins; Enzyme Inhibitors; Female; Glutamate-Cysteine Ligase; Glutathione; HCT116 Cells; Humans; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Nuclear Proteins; Ovarian Neoplasms; Oxidative Stress; Quinuclidines; Transcription Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Cell Line, Tumor; Cisplatin; Dose-Response Relationship, Drug; Humans; Logistic Models; Models, Theoretical; Quinuclidines

Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Cell Survival; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mutation; Quinuclidines; Tumor Suppressor Protein p53

Topics: Amino Acid Substitution; Brain Stem Neoplasms; Cell Line, Tumor; Dose Fractionation, Radiation; Glioma; Histone Demethylases; Humans; Mutation, Missense; Quinuclidines; Radiation-Sensitizing Agents; Tumor Suppressor Protein p53

Topics: Administration, Topical; Cell Differentiation; Ectodermal Dysplasia; Epidermis; Genotype; Humans; Keratinocytes; Phenotype; Protein Aggregates; Quinuclidines; Transcription Factors; Tumor Suppressor Proteins

Topics: Azacitidine; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Drug Repositioning; Female; Heterografts; High-Throughput Screening Assays; Humans; Kinesins; Mice, Inbred NOD; Mice, SCID; Molecular Targeted Therapy; Neoplasm Transplantation; Quinuclidines; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Drug Repositioning; Drug Screening Assays, Antitumor; Drug Synergism; Female; Fenbendazole; Humans; Mebendazole; Ovarian Neoplasms; Quinuclidines; Random Allocation; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

Topics: Cell Death; Cell Line, Tumor; Humans; Mutation; Neoplasms; Pharmaceutical Preparations; Quinuclidines; Sulfhydryl Compounds; Tumor Suppressor Protein p53

Topics: Cell Death; Ferroptosis; Humans; Leukemia, Myeloid, Acute; Quinuclidines

Topics: Antioxidants; Cell Line, Tumor; HCT116 Cells; HEK293 Cells; Humans; NF-E2-Related Factor 2; Oxidation-Reduction; Oxidative Stress; Quinuclidines; Transketolase; Tumor Suppressor Protein p53

Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Colony-Forming Units Assay; Drug Screening Assays, Antitumor; Drug Synergism; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mutation; Panobinostat; Quinuclidines; Temozolomide; Tumor Suppressor Protein p53

Topics: Apoptosis; Benzothiazoles; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; DNA Replication; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Naphthyridines; Quinuclidines; RNA Polymerase I; Triple Negative Breast Neoplasms

Topics: Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Humans; Leukemia, Myeloid, Acute; Myelodysplastic Syndromes; Quinuclidines; Treatment Outcome; Tumor Cells, Cultured

Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Humans; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Apoptosis; Cell Line, Tumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Mice; Mutation, Missense; Proto-Oncogene Proteins c-bcl-2; Quinuclidines; Reactive Oxygen Species; Signal Transduction; Tumor Protein p73; Tumor Suppressor Protein p53; Up-Regulation; Xenograft Model Antitumor Assays

Topics: Antineoplastic Agents; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Crystallography, X-Ray; Humans; Loss of Function Mutation; Neoplasms; Protein Domains; Quinuclidines; Recombinant Proteins; Tumor Suppressor Protein p53

Topics: Berberine; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Humans; Pancreatic Neoplasms; Quinuclidines; Tumor Suppressor Protein p53

Topics: Adenocarcinoma; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Humans; Pancreatic Neoplasms; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Autoantigens; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Female; Humans; Mice; NF-kappa B; Ovarian Neoplasms; Quinuclidines

Topics: Animals; Ferroptosis; Humans; Iron; Lymphoma, Large B-Cell, Diffuse; Mice; Mutation; Prognosis; Quinuclidines; Tumor Suppressor Protein p53

Topics: Animals; Immune Checkpoint Inhibitors; Mice; Quinuclidines; Tumor Microenvironment; Tumor Suppressor Protein p53; Tumor-Associated Macrophages