Compounds > quinuclidines
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quinuclidines and 1-azabicyclo(2.2.2)oct-3-yl 2-hydroxy-2-(1-iodo-1-propen-3-yl)-2-phenylacetate

quinuclidines has been researched along with 1-azabicyclo(2.2.2)oct-3-yl 2-hydroxy-2-(1-iodo-1-propen-3-yl)-2-phenylacetate in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (75.00)18.2507
2000's3 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jahn, K; Knapp, FF; Lambert, CR; McPherson, DW; McRee, RC; Reba, RC; Sood, V; Zeeberg, B1
Knapp, FF; Lambert, CR; McPherson, DW1
Callahan, AP; DeHaven-Hudkins, DL; Knapp, FF; McPherson, DW1
Boulay, SF; Knapp, FF; McPherson, DW; Rayeq, MR; Sood, VK; Zeeberg, BR1
Boulay, SF; Danesh, RA; Knapp, FF; McPherson, DW; Rayeq, MR; Sood, VK; Zeeberg, BR1
Bergström, KA; Farde, L; Ginovart, N; Hall, H; Halldin, C; Hiltunen, J; Ito, H; Knapp, FF; Larsson, S; McPherson, DW; Schnell, PO; Swahn, CG1
Boulay, SF; Cohen, VI; Danesh, RA; McPherson, DW; Rayeq, MR; Reba, RC; Sood, VK; Zeeberg, BR1
Bergström, KA; Farde, L; Halldin, C; Hiltunen, J; Karlsson, P; Knapp, FF; Larsson, S; McPherson, D; Nobuhara, K; Okubo, Y; Savonen, A; Schnell, PO; Swahn, CG1
Knapp, FF; McPherson, DW1
Beets, AL; Greenbaum, M; Knapp, FF; Luo, H; McPherson, DW1
Bergström, KA; Farde, L; Hall, H; Halldin, C; Hiltunen, J; Karlsson, P; Larsson, SA; McPherson, DW; Nobuhara, K; Pauli, S; Savonen, A; Schnell, PO; Sedvall, G; Swahn, CG1
Bergström, KA; Farde, L; Halldin, C; Hiltunen, J; Karlsson, P; Larsson, SA; McPherson, DW; Nobuhara, K; Olsson, H; Savonen, A; Schnell, PO; Sedvall, G; Swahn, CG1

Other Studies

12 other study(ies) available for quinuclidines and 1-azabicyclo(2.2.2)oct-3-yl 2-hydroxy-2-(1-iodo-1-propen-3-yl)-2-phenylacetate

ArticleYear
Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor.
    Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20

    Topics: Animals; CHO Cells; Cricetinae; Female; Iodine Radioisotopes; Ligands; Muscarinic Antagonists; Quinuclidines; Rats; Receptors, Muscarinic; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

1995
In vivo metabolic studies of the trans-(R,R) isomer of radioiodinated IQNP: a new ligand with high affinity for the M1 muscarinic-cholinergic receptor.
    European journal of nuclear medicine, 1994, Volume: 21, Issue:12

    Topics: Animals; Brain; Female; Heart; Iodine Radioisotopes; Liver; Quinuclidines; Rats; Rats, Inbred Strains; Receptors, Cholinergic; Receptors, Muscarinic; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

1994
Synthesis and biodistribution of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate. A new ligand for the potential imaging of muscarinic receptors by single photon emission computed tomography.
    Journal of medicinal chemistry, 1993, Apr-02, Volume: 36, Issue:7

    Topics: Animals; Brain; Female; Iodine Radioisotopes; Ligands; Quinuclidines; Quinuclidinyl Benzilate; Rats; Receptors, Muscarinic; Structure-Activity Relationship; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

1993
In vivo autoradiographic and dissection evaluation of isomers of 125I-labeled 1-azabicyclo[2.2.2] oct-3-yl-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate (IQNP).
    Receptors & signal transduction, 1996, Volume: 6, Issue:1

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Iodine Radioisotopes; Ligands; Male; Muscarinic Antagonists; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

1996
In vivo autoradiographic competition studies of isomers of [125I]IQNP against QNB demonstrating in vivo m2 muscarinic subtype selectivity for QNB.
    Receptors & signal transduction, 1997, Volume: 7, Issue:1

    Topics: Animals; Autoradiography; Binding, Competitive; Brain; Iodine Radioisotopes; Ligands; Muscarinic Antagonists; Quinuclidines; Quinuclidinyl Benzilate; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Tritium

1997
Evaluation and metabolite studies of 125I- and 123I-labelled E-(R,R)-IQNP: potential radioligands for visualization of M1 muscarinic acetylcholine receptors in brain.
    Nuclear medicine and biology, 1998, Volume: 25, Issue:3

    Topics: Animals; Binding, Competitive; Biperiden; Brain; Humans; Macaca fascicularis; Male; Muscarinic Antagonists; Organ Specificity; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, Muscarinic; Tomography, Emission-Computed, Single-Photon

1998
In vivo competition studies of Z-(-,-)-[125I]IQNP against 3-quinuclidinyl 2-(5-bromothienyl)-2-thienylglycolate (BrQNT) demonstrating in vivo m2 muscarinic subtype selectivity for BrQNT.
    Journal of molecular neuroscience : MN, 1998, Volume: 11, Issue:1

    Topics: Alzheimer Disease; Animals; Autoradiography; Binding, Competitive; Brain; Bromine Radioisotopes; Cryoultramicrotomy; Glycolates; Male; Quinuclidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptors, Muscarinic; Sensitivity and Specificity; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon

1998
Iodine-123 labelled Z-(R,R)-IQNP: a potential radioligand for visualization of M(1 )and M(2) muscarinic acetylcholine receptors in Alzheimer's disease.
    European journal of nuclear medicine, 1999, Volume: 26, Issue:11

    Topics: Alzheimer Disease; Animals; Brain; Iodine Radioisotopes; Ligands; Macaca fascicularis; Male; Muscarinic Antagonists; Quinuclidines; Receptors, Muscarinic; Tomography, Emission-Computed, Single-Photon

1999
A rapid and simple Sep Pak method for purification of radioiodinated IQNP, a high affinity ligand for the muscarinic receptor.
    Nuclear medicine and biology, 1999, Volume: 26, Issue:7

    Topics: Animals; Brain; Female; Iodine Radioisotopes; Ligands; Muscarinic Antagonists; Quinuclidines; Radiopharmaceuticals; Rats; Rats, Inbred F344; Receptors, Muscarinic; Silicon Dioxide; Tissue Distribution

1999
Evaluation of Z-(R,R)-IQNP for the potential imaging of m2 mAChR rich regions of the brain and heart.
    Life sciences, 2000, Volume: 66, Issue:10

    Topics: Animals; Brain; Evaluation Studies as Topic; Female; Myocardium; Quinuclidines; Rats; Rats, Inbred F344; Receptor, Muscarinic M2; Receptors, Muscarinic; Tissue Distribution; Tomography, Emission-Computed, Single-Photon

2000
Z-IQNP: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer's disease.
    Psychopharmacology, 2000, Volume: 149, Issue:1

    Topics: Alzheimer Disease; Animals; Autoradiography; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Macaca fascicularis; Quinuclidines; Radioligand Assay; Receptors, Muscarinic; Stereoisomerism; Tomography, Emission-Computed, Single-Photon

2000
SPET imaging of central muscarinic acetylcholine receptors with iodine-123 labelled E-IQNP and Z-IQNP.
    European journal of nuclear medicine, 2001, Volume: 28, Issue:1

    Topics: Adult; Brain; Central Nervous System; Chromatography, High Pressure Liquid; Humans; Iodine Radioisotopes; Magnetic Resonance Imaging; Male; Models, Biological; Quinuclidines; Radiopharmaceuticals; Receptors, Muscarinic; Stereoisomerism; Tomography, Emission-Computed, Single-Photon

2001