quinoxalines has been researched along with panadiplon in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (87.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blakeman, DP; Carter, DB; Hamilton, BJ; Im, HK; Im, WB; Jacobsen, EJ; Petke, JD; Pregenzer, JF | 1 |
| Baczynskyj, L; O'Leary, IA; Vrbanac, JJ | 1 |
| Harris, LS; Nader, MA; Patrick, GA; Powell, LJ; Winger, G; Woods, JH; Woolverton, WL | 1 |
| Franklin, SR; Himes, CS; Ho, PM; Tang, AH | 1 |
| Oien, TT; Sethy, VH | 1 |
| Zhong, WZ | 1 |
| Bacon, JA; Branstetter, DG; Cramer, CT; Funk, GM; Hunt, CE; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Howard, MR; Martin, IJ; Parton, AH; Speed, W | 1 |
| Code, RA; Himes, CS; Tang, AH | 1 |
| Bacon, JA; Cramer, CT; Peng, GW; Petrella, DK; Stryd, RP; Sun, EL; Ulrich, RG | 1 |
| Bacon, JA; Cramer, CT; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Bacon, JA; Cramer, CT; Holmuhamedov, E; Meglasson, MD; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Ator, NA; Griffiths, RR | 1 |
| Yu, LX | 1 |
| Rowlett, JK; Woolverton, WL | 1 |
| Bacon, JA; Brass, EP; Cramer, CT; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
2 review(s) available for quinoxalines and panadiplon
| Article | Year |
|---|---|
Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development.
Topics: Animals; Cells, Cultured; Cryopreservation; Humans; Liver; Oxadiazoles; Quinoxalines; Spectinomycin | 1995 |
Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon.
Topics: Animals; Anti-Anxiety Agents; Carnitine; Cell Hypoxia; Cells, Cultured; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase I as Topic; Coenzyme A; Drug Evaluation, Preclinical; Hepatocytes; Humans; Mitochondria; Oxadiazoles; Pantothenic Acid; Quinoxalines; Rabbits; Reye Syndrome; Species Specificity | 2001 |
14 other study(ies) available for quinoxalines and panadiplon
| Article | Year |
|---|---|
Characterization of functional interactions of imidazoquinoxaline derivatives with benzodiazepine-gamma-aminobutyric acidA receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Chlorides; Chlorine; Cloning, Molecular; Drug Interactions; Electrophysiology; Flunitrazepam; GABA-A Receptor Antagonists; Kinetics; Male; Membrane Proteins; Models, Chemical; Molecular Conformation; Oxadiazoles; Quinoxalines; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes; Tritium | 1992 |
Utility of the parent-neutral loss scan screening technique: partial characterization of urinary metabolites of U-78875 in monkey urine.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Haplorhini; Humans; Mass Spectrometry; Oxadiazoles; Quinoxalines | 1992 |
Progress report from the Testing Program for Stimulant and Depressant Drugs (1991).
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Central Nervous System Stimulants; Discrimination, Psychological; Female; Flunitrazepam; Humans; Macaca mulatta; Male; Mice; Nitrazepam; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders | 1992 |
Behavioral effects of U-78875, a quinoxalinone anxiolytic with potent benzodiazepine antagonist activity.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Diazepam; Electroencephalography; Flumazenil; Injections, Intraperitoneal; Male; Motor Activity; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred F344 | 1991 |
Role of cGMP in the mechanism of anxiolytic activity of U-78875.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain Chemistry; Carbolines; Cerebellum; Convulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Electroshock; Flunitrazepam; Male; Mice; Muscimol; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Stress, Psychological | 1991 |
Determination of 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)imidazo[1, 5-a]quinoxalin-4(5H)-one in serum by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Oxadiazoles; Quinoxalines | 1991 |
Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic.
Topics: Animals; Anti-Anxiety Agents; DNA; Fatty Liver; Female; Liver Glycogen; Oxadiazoles; Proteins; Quinoxalines; Rabbits; Statistics as Topic | 1995 |
The use of liquid chromatography/thermospray mass spectrometry with on-line ultraviolet diode array and radiochemical detection: characterization of the putative metabolites of U-78875 in female rat faeces.
Topics: Animals; Anti-Anxiety Agents; Biotransformation; Chromatography, Liquid; Feces; Female; Mass Spectrometry; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 1994 |
Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice.
Topics: Animals; Body Temperature; Drug Antagonism; GABA-A Receptor Antagonists; Male; Mice; Oxadiazoles; Quinoxalines; Receptors, GABA-A | 1993 |
Potentiation of hypoxic injury in cultured rabbit hepatocytes by the quinoxalinone anxiolytic, panadiplon.
Topics: Adenosine Triphosphate; Animals; Anti-Anxiety Agents; Cell Death; Cell Hypoxia; Cells, Cultured; Dihydroxyacetone; Drug Synergism; Female; Glycogen; L-Lactate Dehydrogenase; Liver; Oxadiazoles; Oxygen; Pyruvates; Pyruvic Acid; Quinoxalines; Rabbits | 1996 |
Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite.
Topics: Adolescent; Adult; Animals; Anti-Anxiety Agents; Cell Respiration; Cells, Cultured; Child, Preschool; Cyclopropanes; Female; Fluorescent Dyes; Humans; Liver; Male; Middle Aged; Mitochondria, Liver; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rabbits; Rats; Rhodamine 123; Species Specificity | 1998 |
Drug discrimination analysis of partial agonists at the benzodiazepine site. I. Differential effects of U-78875 across training conditions in baboons and rats.
Topics: Acoustic Stimulation; Administration, Oral; Animals; Anti-Anxiety Agents; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Injections, Intraperitoneal; Lorazepam; Male; Oxadiazoles; Papio; Pentobarbital; Photic Stimulation; Quinoxalines; Rats; Rats, Long-Evans | 1999 |
An integrated model for determining causes of poor oral drug absorption.
Topics: Administration, Oral; Algorithms; Anti-Anxiety Agents; Antifungal Agents; Cardiotonic Agents; Computer Simulation; Digoxin; Gastric Emptying; Griseofulvin; Intestinal Absorption; Models, Theoretical; Oxadiazoles; Particle Size; Permeability; Pharmacokinetics; Predictive Value of Tests; Quinoxalines; Solubility | 1999 |
Discriminative stimulus effects of panadiplon (U-78875), a partial agonist at the benzodiazepine site, in pentobarbital-trained rhesus monkeys.
Topics: Animals; Anti-Anxiety Agents; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA Modulators; Macaca mulatta; Male; Oxadiazoles; Pentobarbital; Quinoxalines; Reaction Time; Receptors, GABA-A; Triazolam | 2001 |