quinoxalines has been researched along with oxadiazoles in 851 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (2.00) | 18.7374 |
| 1990's | 167 (19.62) | 18.2507 |
| 2000's | 514 (60.40) | 29.6817 |
| 2010's | 143 (16.80) | 24.3611 |
| 2020's | 10 (1.18) | 2.80 |
| Authors | Studies |
|---|---|
| Supko, DE; Uretsky, NJ; Wallace, LJ | 1 |
| Johansson, BB; Westergren, I | 1 |
| Blakeman, DP; Carter, DB; Hamilton, BJ; Im, HK; Im, WB; Jacobsen, EJ; Petke, JD; Pregenzer, JF | 1 |
| Baczynskyj, L; O'Leary, IA; Vrbanac, JJ | 1 |
| Lanius, RA; Shaw, C | 1 |
| Harris, LS; Nader, MA; Patrick, GA; Powell, LJ; Winger, G; Woods, JH; Woolverton, WL | 1 |
| Baudry, M; Massicotte, G; Standley, S; Thompson, RF; Tocco, G | 1 |
| Keith, RA; Moore, WC; Patel, J; Salama, AI | 1 |
| Buchan, AM; Huang, ZG; Lesiuk, H; Smith, KH; Xue, D | 1 |
| Franklin, SR; Himes, CS; Ho, PM; Tang, AH | 1 |
| Oien, TT; Sethy, VH | 1 |
| Zhong, WZ | 3 |
| Cha, JH; Drejer, J; Honoré, T; Nielsen, EO; Young, AB | 1 |
| Glaum, SR; Holzwarth, JA; Miller, RJ | 1 |
| Freed, WJ; Jurson, PA | 1 |
| Kimura, F; Nishigori, A; Tsumoto, T | 1 |
| Hansen, AJ; Honoré, T; Jacobsen, P; Nielsen, EO; Sheardown, MJ | 1 |
| Keith, RA; Klika, AB; Mangano, TJ; Patel, J; Salama, AI; Zinkand, WC | 1 |
| Buckley, KS; Collins, GG | 1 |
| Blake, JF; Brown, MW; Collingridge, GL; Yates, RG | 1 |
| Harris, EW | 1 |
| Miller, RJ; Murphy, SN | 1 |
| Garthwaite, G; Garthwaite, J | 1 |
| Dubinsky, JM; Rothman, SM; Yamada, KA | 1 |
| Drejeŕ, J; Honore, T; Nielsen, EO; Nielsen, M | 1 |
| Andreasen, M; Jensen, MS; Lambert, JD | 1 |
| Aizenman, E; Karschin, A; Lipton, SA | 1 |
| Baraban, JM; Stratton, KR; Worley, PF | 1 |
| Drejer, J; Honoré, T | 1 |
| Berney, D; Frey, P; Herrling, PL; Mueller, W; Urwyler, S | 1 |
| Sheardown, MJ | 1 |
| Blake, JF; Brown, MW; Collingridge, GL | 1 |
| Ben-Ari, Y; Cherubini, E; Gho, M; Neuman, RS | 1 |
| Aram, JA; Fletcher, EJ; Honoré, T; Lodge, D; Martin, D | 1 |
| Dooley, DJ; Hertting, G; Lupp, A; Osswald, H | 1 |
| Carter, DB; Im, WB; Smith, MW; Tang, AH; VonVoigtlander, PF | 1 |
| Brunner, F; Kukovetz, WR; Stessel, H | 1 |
| Boulton, CL; Garthwaite, J; Mayer, B; Nielsen, EB; Schmidt, K; Southam, E | 1 |
| Bacon, JA; Branstetter, DG; Cramer, CT; Funk, GM; Hunt, CE; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Howard, MR; Martin, IJ; Parton, AH; Speed, W | 1 |
| Code, RA; Himes, CS; Tang, AH | 1 |
| Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF | 1 |
| Boulton, CL; Garthwaite, J; Southam, E | 1 |
| Bacon, JA; Cramer, CT; Peng, GW; Petrella, DK; Stryd, RP; Sun, EL; Ulrich, RG | 1 |
| Brunner, F; Mayer, B; Nielsen, EB; Schmidt, K | 1 |
| Cellek, S; Darley-Usmar, VM; Lizasoain, I; Moncada, S; Moro, MA; Radomski, MW; Russel, RJ; Su, Y | 1 |
| Bacon, JA; Cramer, CT; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Behrends, S; Koesling, D; Mayer, B; Schmidt, K; Schrammel, A | 1 |
| Cellek, S; Kasakov, L; Moncada, S | 1 |
| Kawabata, A | 1 |
| Charles, SL; Garthwaite, J; Southam, E | 1 |
| Fedele, E; Jin, Y; Raiteri, M; Varnier, G | 1 |
| Boxall, AR; Garthwaite, J | 1 |
| Ciampoli, D; Johnson, PJ; Stebbing, MJ; Young, HM | 1 |
| Graham, A; Owen, JS; Riddell, DR | 1 |
| Loweth, AC; Morgan, NG; Scarpello, JH; Williams, GT | 1 |
| Drewett, JG; Herzig, TC; Knych, ET; Olson, LJ | 1 |
| Brown, JC; Burns, DM; Dykes, EL; Flitney, FW; Hirst, DG; Kennovin, GD; Ruddock, MW | 1 |
| Faraci, FM; Sobey, CG | 3 |
| Burke-Gaffney, A; Hellewell, PG | 1 |
| Branka, JE; Jarry, A; Laboisse, CL; Vallette, G | 1 |
| Cocks, TM; Satchell, DG; Selemidis, S | 1 |
| Cellek, S; Moncada, S | 2 |
| Duszyk, M; Kamosinska, B; Man, SF; Radomski, A; Radomski, MW | 1 |
| Gage, AT; Reyes, M; Stanton, PK | 1 |
| Bloch, DB; Bloch, KD; Filippov, G | 1 |
| Akgören, N; Lauritzen, M; Mathiesen, C; Rubin, I | 1 |
| Cheung, PY; Schulz, R | 1 |
| Brien, JF; Hussain, AS; Marks, GS; Nakatsu, K | 1 |
| Ichinose, M; Sawada, M; Stefano, GB | 1 |
| Chu, HP; Etgen, AM | 1 |
| Alam, J; Choi, AM; Cook, JL; Hartsfield, CL | 1 |
| Franck, H; Sanders, KM; Shuttleworth, CW; Sweeney, KM | 1 |
| Díaz-Cazorla, M; Jiménez, W; Lamas, S; Pérez-Sala, D; Ros, J | 1 |
| Morris, R; Thippeswamy, T | 1 |
| Campbell, WB; Jin, MW; Li, PL | 1 |
| Cantabrana, B; Hidalgo, A; Menéndez Antolin, L; Pérez Vallina, JR; Sánchez, M | 1 |
| Cui, XL; Douglas, JG; Granger, HJ; Hood, JD; Ledda, F; Morbidelli, L; Parenti, A; Ziche, M | 1 |
| Hebeiss, K; Kilbinger, H | 1 |
| Canning, BJ; Fischer, A | 1 |
| Faraci, FM; Heistad, DD; Maeda, N; Shesely, EG; Sigmund, CD | 1 |
| Cohen, A; Fouty, B; Komalavilas, P; Lincoln, TM; McMurtry, IF; Muramatsu, M; Rodman, DM | 1 |
| Gustafsson, LE; Hallén, K; Iversen, HH; Olgart, C; Wiklund, NP | 1 |
| Nawy, S; Stanton, PK; Wexler, EM | 1 |
| Catalin, D; Miolan, JP; Niel, JP; Quinson, N | 2 |
| Katusic, ZS; Onoue, H | 1 |
| Anwyl, R; Rowan, MJ; Wang, Y; Wu, J | 1 |
| Barbeito, L; Beckman, JS; Cornwell, TL; Estévez, AG; Radi, R; Spear, N; Thompson, JA | 1 |
| Bayguinov, O; Sanders, KM | 1 |
| Li, L; Paakkari, I; Vaali, K; Vapaatalo, H | 1 |
| Doughty, JM; Langton, PD | 1 |
| Ali, IS; Clanachan, AS; Finegan, BA; Gandhi, M; Koshal, A | 1 |
| de Vente, J; Hopkins, DA; Markerink-van Ittersum, M; Steinbusch, HW | 1 |
| Anraku, M; Ichinose, M; Sawada, M | 2 |
| Gordge, MP; Hothersall, JS; Noronha-Dutra, AA | 1 |
| Kanadia, RN; Kuo, WN; Mcnabb, M | 1 |
| Bartfai, T; Caltavuturo, C; Consolo, S; Uboldi, MC | 1 |
| Ackermann, A; Fernández-Alfonso, MS; González, C; Ortega, T; Paul, M; Sánchez de Rojas, R | 1 |
| Bredt, DS; Morton, DB | 1 |
| Cocks, TM; Sobey, CG | 1 |
| Bohle, DS | 1 |
| Gean, PW; Lu, KT | 1 |
| Contreras, J; García-Sacristán, A; Hernández, M; López, PG; Prieto, D; Recio, P | 1 |
| Muneoka, Y; Pedder, SM; Walker, RJ | 1 |
| Aley, KO; Levine, JD; McCarter, G | 1 |
| Hiley, CR; White, R | 1 |
| Lefebvre, RA | 1 |
| Freitag, A; Racké, K; Wessler, I | 1 |
| Behrends, S; Harteneck, C; Koesling, D; Russwurm, M | 1 |
| Chen, SJ; Wu, CC; Yen, MH | 1 |
| Campbell, WB; Drewett, JG; Hanke, CJ; Myers, CR | 1 |
| Caudill, TK; Kanagy, NL; Resta, TC; Walker, BR | 1 |
| Bauer, PM; Buga, GM; Fukuto, JM; Ignarro, LJ; Wei, LH | 1 |
| Homer, K; Wanstall, J | 1 |
| Ruiz, E; Tejerina, T | 1 |
| Polte, T; Schröder, H | 1 |
| Goyal, RK; He, XD | 1 |
| Holmes, EP; Krautmann, MJ; Maher, TJ; Venugopalan, CS | 1 |
| Fernández-Tomé, P; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA | 2 |
| Heerdt, E; Janssen, YM; Joseph, J; Kalyanaraman, B; Singh, RJ; Soultanakis, R; Steece, K | 1 |
| Hwang, TL; Teng, CM; Wu, CC | 1 |
| Cena, C; Di Stilo, A; Ermondi, G; Gasco, A; Gasco, AM; Visentin, S | 1 |
| Bacon, JA; Cramer, CT; Holmuhamedov, E; Meglasson, MD; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Cohen, RA; Griswold, MC; Komalavilas, P; Lincoln, TM; Weisbrod, RM; Yaghoubi, M | 1 |
| Aizman, R; Brismar, H; Celsi, G | 1 |
| Alm, P; Ekström, P; Henningsson, R; Lundquist, I | 1 |
| Brown, AS; Cramer, EM; Darley-Usmar, V; Masse, JM; Moro, MA; Radomski, M | 1 |
| Akashi, C; Matsumura, Y; Mitsutomi, N; Odagiri, J | 1 |
| Frölich, JC; Ikic, M; Raida, M; Tewes, KS; Tsikas, D | 1 |
| Deichmann, PC; Falck, JR; Imig, JD; Inscho, EW; Reddy, KM | 1 |
| Baik, YH; Cho, KW; Chung, SS; Kang, SY; Kook, H; Lee, SE; Rhee, JH | 1 |
| Kawana, S; Miyamoto, A; Namiki, A; Ohshika, H; Yamamoto, S | 1 |
| Carvalho, AP; Carvalho, CM; Sequeira, SM | 1 |
| Brown, C; Hassid, A; Pan, X | 1 |
| Dasso, M; Rosenzweig, S; Spielman, AI; Yan, W | 1 |
| Durham, PL; Russo, AF | 1 |
| Fiore, SA; Homer, KL; Wanstall, JC | 1 |
| Bryan, RM; Johnson, TD; Marrelli, SP; Mombouli, JV; You, J | 1 |
| Jacklet, JW; Koh, HY | 1 |
| Rehder, V; Van Wagenen, S | 1 |
| De la Lande, IS; Horowitz, JD; Stafford, I | 1 |
| Diamond, J; Sandirasegarane, L | 2 |
| Agulló, L; García-Dorado, D; Inserte, J; Llevadot, J; Paniagua, A; Pyrhonen, P; Soler-Soler, J | 1 |
| Berg, G; Dominiczak, AF; Hamilton, CA; McArthur, K; Reid, JL | 1 |
| Ator, NA; Griffiths, RR | 1 |
| Berni, LA; Gai, P; Mannaioni, PF; Masini, E; Mirabella, C; Ndisang, JF | 1 |
| Allescher, HD; Fritsch, R; Kurjak, M; Saur, D; Schusdziarra, V | 1 |
| Bicker, G; Wildemann, B | 1 |
| Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U | 1 |
| D'Angelo, S; Mulè, F; Serio, R | 1 |
| Cunha, FQ; Ferreira, SH; Teixeira, MM | 1 |
| Closs, EI; Förstermann, U; Nawrath, H; Wegener, JW | 1 |
| Alves-Do-Prado, W; Ambiel, CR; Silva, HM | 1 |
| Alfonzo, MJ; González de Alfonzo, R; Guerra de González, L; Lippo de Bécemberg, I; Misle, A; Napoleón de Herrera, V; Pacheco, G | 1 |
| Clement, B; Feelisch, M; Kotsonis, P; Schmidt, HH; Siebe, J | 1 |
| Duszyk, M; Thethi, K | 1 |
| Gibson, A; O'Kane, K | 1 |
| Furukawa, T; Katsuragi, T; Kushiku, K; Noguchi, H; Ono, N; Yamada, H; Yamada, K | 1 |
| Sanders, KM; Shuttleworth, CW; Sweeney, KM | 1 |
| Carlson, EJ; Drewett, JG; Kreklau, EL | 1 |
| Cantoni, O; Clementi, E; Guidarelli, A; Sciorati, C | 1 |
| Haskó, G; Salzman, AL; Szabó, C; Zingarelli, B | 1 |
| Alves-Do-Prado, W; Cruciol-Souza, JM | 1 |
| Budelmann, BU; Tu, Y | 2 |
| Gong, GX; Scholz, PM; Straznicka, M; Tse, J; Weiss, HR; Yan, L | 1 |
| Kawamata, T; Omote, K | 1 |
| Briski, KP | 1 |
| Jongsma, J; Noordzij, MA; Oomen, MH; Romijn, JC; Schröder, FH; van Der Kwast, TH; van Steenbrugge, GJ | 1 |
| Chesnais, JM; Fischmeister, R; Mery, PF | 1 |
| Alonso-Galicia, M; Harder, DR; Hudetz, AG; Roman, RJ; Shen, H | 1 |
| Brown, T; Bunton, D; MacDonald, A; McGrath, JC; Shaw, AM; Tracey, A | 1 |
| Gupte, SA; Phillibert, D; Rupawalla, T; Wolin, MS | 1 |
| Fox-Robichaud, A; Kubes, P; Payne, D | 1 |
| Chen, G; Ebner, TJ; Iadecola, C; Yang, G | 1 |
| Vaziri, ND; Wang, XQ | 1 |
| Koshita, M; Nakahira, Y; Suzuki, H; Takano, H | 1 |
| Aguilar, E; González, D | 1 |
| Berkels, R; Klaus, W; Roesen, R; Suerhoff, S | 1 |
| Fung, HL; Tabrizi-Fard, MA; Tseng, CM | 1 |
| Allen, JC; Kahn, AM; Seidel, CL; Zhang, S | 1 |
| Yu, LX | 1 |
| Conklin, JL; Cullen, JJ; Hinkhouse, MM | 1 |
| Bae, HR; Bae, KW; Kang, EK; Lee, SA; Park, HT; Park, JK | 1 |
| Ekblad, E | 1 |
| Costa, G; Garcia-Pascual, A; Labadia, A; Triguero, D | 1 |
| Buus, NH; Mulvany, MJ; Pilegaard, HK; Simonsen, U | 1 |
| Boyle, JP; Fish, HJ; Hanvesakul, R; Lacy, PS; Pilkington, G; Thurston, H | 1 |
| Costa, G; García-Pascual, A; Jiménez, E; Labadía, A; Triguero, D | 1 |
| Hall, SR; Jhamandas, K; Milne, B; Sullivan, ME | 1 |
| Allaerts, W; Buzzi, M; Koopman, WJ; Steerenberg, PA; Verlaan, BP | 1 |
| Cocks, TM; Selemidis, S | 1 |
| Baydoun, AR; Edwards, RJ; Mann, GE; Marber, MS; Mockridge, JW; Rakhit, RD; Wyatt, AW | 1 |
| Gordon, JB; Halla, TR; Madden, JA | 1 |
| Liu, XD; Rennard, SI; Romberger, DJ; Skold, CM; Spurzem, JR; Umino, T | 1 |
| Aguirre-Bañuelos, P; Granados-Soto, V | 1 |
| Barsacchi, R; Cantoni, O; Clementi, E; De Nadai, C; Lièvremont, JP; Meldolesi, J; Moncada, S; Sciorati, C; Sestili, P | 1 |
| Brune, K; Hinz, B; Pahl, A | 1 |
| Bussygina, OG; Khropov, YV; Makhova, NN; Ovchinnikov, IV; Pyatakova, NV; Severina, IS | 1 |
| Huh, IH; Lee, YW; Park, JI; Shin, CY; Sohn, UD | 1 |
| Jonas, M; Mundey, MK; Scholefield, JH; Wilson, VG; Worthley, T | 1 |
| Rosenberg, R; Volke, V; Wegener, G | 1 |
| O'Neill, MF; Tomkins, DM | 1 |
| Kato, T; Nakamura, K; Yamamoto, H; Yamamoto, T; Yuyama, K | 1 |
| Dick, JM; Lefebvre, RA | 1 |
| Bény, JL; Flammer, J; Fleischhauer, JC; Haefliger, IO | 1 |
| Brawley, L; MacDonald, A; Shaw, AM | 1 |
| Flammer, J; Fleischhauer, JC; Haefliger, IO | 1 |
| Patel, KN; Scholz, PM; Weiss, HR | 1 |
| Duarte, ID; Ferreira, SH | 1 |
| Hata, F; Nakagawa, M; Niioka, S; Nishio, H; Okishio, Y; Takeuchi, T; Yamaji, M | 1 |
| Andersson, KE; Mizusawa, H; Pandita, RK | 1 |
| Huang, MW; Scholz, PM; Weiss, HR; Yan, L | 1 |
| Kurowski, S; Vemulapalli, S | 2 |
| Falck, JR; Harder, DR; Okamoto, H; Roman, RJ; Sun, CW | 1 |
| Jiang, F; Li, CG; Rand, MJ | 1 |
| Barrachina, MD; Esplugues, JV; García-Zaragozá, E; Moreno, L | 1 |
| Becherini, L; MacIntyre, I; Mancini, L; Martineti, V; Moradi-Bidhendi, N | 1 |
| Johns, RA; Li, D; Shirakami, G; Zhan, X | 1 |
| Marcoli, M; Maura, G; Pepicelli, O; Raiteri, M; Rosu, C; Viola, C | 1 |
| Cole, WC; Dong, H; Jiang, Y; Triggle, CR | 1 |
| Kilbinger, H; Mang, CF | 1 |
| Clark, E; Conklin, JL; Murray, JA; Shahin, W | 1 |
| Butler, AR; Mazzei, FA; Megson, IL; Miller, MR; Roseberry, MJ; Webb, DJ | 2 |
| Babcock, GT; Brandish, PE; Di Valentin, M; DiValentin, M; Marletta, MA; Schelvis, JP; Zhao, Y | 1 |
| Baumgarten, G; Dibbs, Z; Kalra, D; Mann, DL; Seta, Y; Sivasubramanian, N | 1 |
| Chen, SJ; Lin, CI; Wu, CC; Yang, SN; Yen, MH | 1 |
| Gandhi, CR; Kuddus, R; Uemura, T | 1 |
| Adachi, T; Hara, H; Mitani, N | 1 |
| Hashida-Okumura, A; Iimori, S; Kobayashi, K; Kobayashi, Y; Nagai, K; Nakashima, H | 1 |
| Ekelund, UE; Georgakopoulos, D; Hare, JM; Harrison, RW; Isoda, T; Kass, DA; Ozaki, M; Paolocci, N; Vandegaer, K | 1 |
| Tiritilli, A | 1 |
| Golding, S; Herring, N; Paterson, DJ | 1 |
| Lovren, F; Triggle, C | 1 |
| Bicker, G; Seidel, C | 1 |
| Homer, KL; Wanstall, JC | 2 |
| Berggren, PO; Cooney, RV; Sjöholm, A | 1 |
| Carter, EP; McMurtry, IF; Morio, Y; Sato, K | 1 |
| Karlsson, AM; Loitto, VM; Nilsson, HM; Sundqvist, T; Svensson, SP | 1 |
| Ellis, DZ; Nathanson, JA; Sweadner, KJ | 1 |
| Genade, S; Lochner, A; Marais, E; Moolman, JA | 1 |
| Magid, KS; Megson, IL; Shaw, CA; Sogo, N; Webb, DJ | 1 |
| Aida, M; Igarashi, T; Kaneko, H; Mochizuki, Y; Shigenobu, K; Tanaka, H; Tanaka, Y; Taniguchi, H; Yamaki, F | 1 |
| Aldinucci, C; Benocci, A; Frosini, M; Meini, A; Palmi, M; Pessina, G; Sgaragli, G; Youmbi, GT | 1 |
| Al-Hassani, M; Gupta, MP; Hart, CM; Natarajan, V; Ober, MD; Patterson, C | 1 |
| Ikeo, T; Inoue, H; Kikkawa, K; Mochida, H; Noto, T; Takagi, M; Yano, K | 1 |
| Gerstenblith, G; Hare, JM; Lakatta, EG; Ricker, KM; Rosas, GO; Vandegaer, K; Zieman, SJ | 1 |
| Hanna, ST; Peterson-Wakeman, R; Wang, R; Wang, Z; Wu, L | 1 |
| Axer, H; Steinbusch, HW; Teunissen, CE | 1 |
| Eguchi, D; Katusic, ZS | 1 |
| Gustafsson, LE; Hallén, K; Olgart, C; Wiklund, NP | 1 |
| Rowlett, JK; Woolverton, WL | 1 |
| Baccari, MC; Calamai, F | 1 |
| Cernuda-Morollón, E; Díaz-Cazorla, M; Lamas, S; Pérez-Sala, D; Rodríguez-Pascual, F | 1 |
| Mayeux, PR; Zhang, C | 1 |
| Duszyk, M; Jurasz, P; Mayers, I; Miranda, C; Radomski, MW; Sawicka, J; Sawicki, G | 1 |
| Hartell, NA; Reynolds, T | 1 |
| Branco, LG; Steiner, AA | 1 |
| Didion, SP; Faraci, FM; Heistad, DD | 1 |
| Diamond, J; Hennan, JK | 1 |
| Aonuma, H; Newland, PL | 1 |
| Dusting, GJ; Jiang, F | 1 |
| Conklin, JL; Kooy, N; Murray, JA; Uc, A | 1 |
| Prado, WA; Sousa, AM | 1 |
| Alloatti, G; Bedendi, I; Biasin, C; Gallo, MP; Levi, RC; Malan, D | 1 |
| Ferreyra, GA; Golombek, DA | 1 |
| Kizawa, Y; Kusama, T; Murakami, H; Ohuchi, N; Saito, K | 1 |
| De Iuri, L; Imbrogno, S; Mazza, R; Tota, B | 1 |
| Huang, Q; Huang, X; Jin, C; Liu, J; Yang, GY; Zhao, KS | 1 |
| Bacon, JA; Brass, EP; Cramer, CT; Petrella, DK; Sun, EL; Ulrich, RG | 1 |
| Ahn, D; Chung, S; Kwon, S; Nam, T; Yeon, D | 1 |
| Alving, K; Björne, H; Herulf, M; Lundberg, JO; Modin, A; Weitzberg, E | 1 |
| Ingram, JN; Renfree, MB; Shaw, G | 1 |
| Ho-Pao, CL; Leamey, CA; Sur, M | 1 |
| Aldieri, E; Bosia, A; Costamagna, C; Ghigo, D; Lindblom, B; Massobrio, M; Moffa, F; Ochetti, S; Revelli, A | 1 |
| Anfossi, G; Cavalot, F; Massucco, P; Mattiello, L; Russo, I; Trovati, M | 1 |
| Ke, X; Nabika, T; Nakashima, Y; Nariai, Y; Tanigawa, Y; Terashima, M | 1 |
| Savage, T; Tribe, RM; Yaqoob, MM | 1 |
| Dikmen, A; Döndaş, N; Ergün, Y; Oğülener, N | 1 |
| Brodowsky, R; Dirnagl, U; Dreier, JP; Klee, R; Lindauer, U; Lobsien, E; Schuh-Hofer, S; Vogt, J | 1 |
| Ratz, PH | 1 |
| Gonzalez, A; Sarna, SK | 1 |
| Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| Garland, CJ; Plane, F; Sampson, LJ; Smith, JJ | 1 |
| de Groat, WC; Seki, S; Yoshimura, N | 1 |
| Bonavita, F; Facchini, A; Flamigni, F; Stanic, I; Stefanelli, C; Tantini, B | 1 |
| Gupte, SA; Okada, T | 1 |
| Basini, G; Bussolati, S; Grasselli, F; Ponderato, N; Tamanini, C | 1 |
| Brenner, M; Löscher, W; Palluk, R; Pieper, M; Potschka, H; Weiser, T; Wienrich, M | 1 |
| Gitlin, JM; Mitchell, JA; Stanford, SJ | 1 |
| Boon, K; Fooks, HM; Hourani, SM; Prentice, DJ | 1 |
| Bendhack, LM; Ceron, PI; Cremonez, DC; Tedesco, AC | 1 |
| Gandhi, CR; Uemura, T | 1 |
| Castel, H; Vaudry, H | 1 |
| Brioni, JD; Hsieh, GC; Kolasa, T; Sullivan, JP | 1 |
| Berkels, R; Chatterjee, PK; Cuzzocrea, S; Foster, SJ; Olbrich, A; Thiemermann, C; Zacharowski, K | 1 |
| Fernández, E; Jiménez, M; Tanović, A | 1 |
| Bivalacqua, TJ; Champion, HC; Coy, DH; Kadowitz, PJ; Murphy, WA; Pierce, RL | 1 |
| Allescher, HD; Geisler, F; Neuhuber, WL; Schusdziarra, V; Storr, M | 1 |
| Brenner, M; Kubiak, R; Palluk, R; Weckesser, G; Weiser, T; Wienrich, M | 1 |
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| Kaneko, D; Koketsu, M; Ninomiya, M; Nishina, A; Ono, Y; Sonawane, AD; Tanaka, K; Yoshikawa, R | 1 |
| Almanza-Pérez, JC; Arias-Durán, L; Estrada-Soto, S; Hernández-Morales, M; Ibarra-Barajas, M; Millán-Pacheco, C; Navarrete-Vázquez, G; Villalobos-Molina, R | 1 |
| Asgari, MS; Barzegari, E; Gulçin, İ; Larijani, B; Mahdavi, M; Mirzazadeh, R; Mohammadi-Khanaposhtani, M; Pedrood, K; Rahmani, H; Rastegar, H; Sherafati, M; Taslimi, P; Üç, EM | 1 |
| Abeed, AAO; Alharthi, S; El-Emary, T | 1 |
| Clark, BJ; El-Mallakh, RS; Gao, Y; Hamlyn, JM; Tegin, G | 1 |
6 review(s) available for quinoxalines and oxadiazoles
| Article | Year |
|---|---|
Cultured hepatocytes as investigational models for hepatic toxicity: practical applications in drug discovery and development.
Topics: Animals; Cells, Cultured; Cryopreservation; Humans; Liver; Oxadiazoles; Quinoxalines; Spectinomycin | 1995 |
Pathophysiological chemistry of nitric oxide and its oxygenation by-products.
Topics: Guanylate Cyclase; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Vasodilation | 1998 |
Metabolic, idiosyncratic toxicity of drugs: overview of the hepatic toxicity induced by the anxiolytic, panadiplon.
Topics: Animals; Anti-Anxiety Agents; Carnitine; Cell Hypoxia; Cells, Cultured; Chemical and Drug Induced Liver Injury; Clinical Trials, Phase I as Topic; Coenzyme A; Drug Evaluation, Preclinical; Hepatocytes; Humans; Mitochondria; Oxadiazoles; Pantothenic Acid; Quinoxalines; Rabbits; Reye Syndrome; Species Specificity | 2001 |
Isoforms of NO-sensitive guanylyl cyclase.
Topics: Animals; Guanylate Cyclase; Isoenzymes; Nitric Oxide; Organ Specificity; Oxadiazoles; Quinoxalines | 2002 |
Role of nitric oxide in brain regions related to defensive reactions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anxiety; Behavior, Animal; Brain; Cats; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Excitatory Amino Acid Antagonists; Free Radical Scavengers; GABA Modulators; Imidazoles; Immunohistochemistry; Maze Learning; Midazolam; Models, Biological; NADPH Dehydrogenase; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats | 2005 |
Topics: 3T3-L1 Cells; A Kinase Anchor Proteins; Acetates; Achilles Tendon; Acute Kidney Injury; Acute Pain; Acyclic Monoterpenes; Adenine Nucleotides; Adhesins, Escherichia coli; Adipocytes; Adipocytes, Brown; Adipogenesis; Administration, Inhalation; Administration, Oral; Adrenal Cortex Hormones; Adsorption; Adult; Aeromonas hydrophila; Africa; Aged; Aged, 80 and over; Agrobacterium tumefaciens; Air; Air Pollutants; Air Pollution; Air Pollution, Indoor; Algorithms; Alkaloids; Alkynes; Allosteric Regulation; Amines; Amino Acid Sequence; Amino Acids; Amino Acids, Branched-Chain; Aminoisobutyric Acids; Aminopyridines; Amyotrophic Lateral Sclerosis; Anaerobic Threshold; Angiography; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animal Distribution; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Ankle Joint; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Inflammatory Agents; Antibodies, Bacterial; Antifungal Agents; Antimalarials; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antioxidants; Antiretroviral Therapy, Highly Active; Antiviral Agents; Aotidae; Apelin; Apoptosis; Arabidopsis Proteins; Argentina; Arginine; Artemisinins; Arthritis, Experimental; Arthritis, Rheumatoid; Arthroscopy; Aspergillus; Aspergillus niger; Asteraceae; Asthma; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Auditory Cortex; Autoantibodies; Autophagy; Bacteria; Bacterial Infections; Bacterial Proteins; Bacterial Typing Techniques; Base Composition; Base Sequence; Basketball; Beclin-1; Benzhydryl Compounds; Benzimidazoles; Benzo(a)pyrene; Benzofurans; Benzoxazines; Bereavement; beta Catenin; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Betacoronavirus; Betaine; Binding Sites; Biofilms; Biological Assay; Biological Availability; Biological Evolution; Biomarkers; Biomechanical Phenomena; Biopolymers; Biopsy; Bismuth; Blood Glucose; Blood Platelets; Blood Pressure; Body Composition; Body Weight; Bone Marrow; Bone Marrow Cells; Bone Regeneration; Boron; Botrytis; Brain Ischemia; Brain Neoplasms; Brain-Derived Neurotrophic Factor; Brazil; Breast Neoplasms; Breath Tests; Bronchoalveolar Lavage Fluid; Burkholderia; C-Reactive Protein; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcification, Physiologic; Calcium; Calcium Signaling; Calorimetry, Differential Scanning; Cameroon; Camptothecin; Candida; Candida albicans; Capillaries; Carbapenem-Resistant Enterobacteriaceae; Carbapenems; Carbohydrate Conformation; Carbon; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ovarian Epithelial; Cardiac Output; Cardiomyopathy, Hypertrophic; Cardiotonic Agents; Cardiovascular Diseases; Caregivers; Carps; Case-Control Studies; Catalase; Catalysis; Cats; CD4 Lymphocyte Count; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Cellulose; Centrosome; Ceratopogonidae; Chickens; Child; China; Cholera Toxin; Choline; Cholinesterases; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Chromatography, Reverse-Phase; Chronic Disease; Cinnamates; Cities; Citrates; Climate Change; Clinical Trials, Phase III as Topic; Coal; Coal Mining; Cohort Studies; Coinfection; Colchicine; Colony Count, Microbial; Colorectal Neoplasms; Coloring Agents; Common Cold; Complement Factor H; Computational Biology; Computer Simulation; Continuous Positive Airway Pressure; Contrast Media; Coordination Complexes; Coronary Artery Bypass; Coronavirus 3C Proteases; Coronavirus Infections; Coronavirus Protease Inhibitors; Corynebacterium glutamicum; Cosmetics; COVID-19; Creatinine; Cross-Sectional Studies; Crotonates; Crystallography, X-Ray; Cues; Culicidae; Culture Media; Curcuma; Cyclopentanes; Cyclopropanes; Cymbopogon; Cystine; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C19 Inhibitors; Cytokines; Databases, Genetic; Death; Dendritic Cells; Density Functional Theory; Depsides; Diabetes Mellitus, Type 2; Diamond; Diarylheptanoids; Dibenzofurans; Dibenzofurans, Polychlorinated; Diclofenac; Diet; Dietary Carbohydrates; Dietary Supplements; Diffusion Magnetic Resonance Imaging; Dioxins; Diphenylamine; Disease Outbreaks; Disease Susceptibility; Disulfides; Dithiothreitol; Dizocilpine Maleate; DNA Methylation; DNA-Binding Proteins; DNA, Bacterial; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Doublecortin Protein; Drosophila melanogaster; Droughts; Drug Carriers; Drug Combinations; Drug Delivery Systems; Drug Liberation; Drug Resistance; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Dust; Dynactin Complex; Dysferlin; Echo-Planar Imaging; Echocardiography; Edaravone; Egypt; Elasticity; Electrodes; Electrolytes; Emodin; Emtricitabine; Endometriosis; Endothelium, Vascular; Endotoxins; Energy Metabolism; Energy Transfer; Enterobacteriaceae; Enterococcus faecalis; Enterotoxigenic Escherichia coli; Environmental Monitoring; Enzyme Inhibitors; Epidemiologic Factors; Epigenesis, Genetic; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Vaccines; Esophageal Neoplasms; Esophagectomy; Esophagogastric Junction; Esterases; Esterification; Ethanol; Ethiopia; Ethnicity; Eucalyptus; Evidence-Based Practice; Exercise; Exercise Tolerance; Extracorporeal Membrane Oxygenation; Family; Fatty Acids; Feedback; Female; Ferric Compounds; Fibrin Fibrinogen Degradation Products; Filtration; Fish Diseases; Flavonoids; Flavonols; Fluorodeoxyglucose F18; Follow-Up Studies; Food Microbiology; Food Preservation; Forests; Fossils; Free Radical Scavengers; Freund's Adjuvant; Fruit; Fungi; Gallium; Gender Identity; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Bacterial; Genes, Plant; Genetic Predisposition to Disease; Genitalia; Genotype; Glomerulonephritis, IGA; Glottis; Glucocorticoids; Glucose; Glucuronides; Glutathione Transferase; Glycogen Synthase Kinase 3 beta; Gram-Negative Bacterial Infections; Gram-Positive Bacterial Infections; Grassland; Guinea Pigs; Half-Life; Head Kidney; Heart Atria; Heart Rate; Heart Septum; HEK293 Cells; Hematopoietic Stem Cells; Hemodynamics; Hep G2 Cells; Hepacivirus; Hepatitis C; Hepatitis C, Chronic; Hepatocytes; Hesperidin; High-Frequency Ventilation; High-Temperature Requirement A Serine Peptidase 1; Hippocampus; Hirudins; History, 20th Century; History, 21st Century; HIV Infections; Homeostasis; Hominidae; Housing, Animal; Humans; Hydrocarbons, Brominated; Hydrogen Bonding; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hydroxyl Radical; Hypertension; Hypothyroidism; Image Interpretation, Computer-Assisted; Immunoconjugates; Immunogenic Cell Death; Indoles; Infant, Newborn; Infant, Premature; Infarction, Middle Cerebral Artery; Inflammation; Inflammation Mediators; Infrared Rays; Inhibitory Concentration 50; Injections, Intravenous; Interferon-gamma; Interleukin-23; Interleukin-4; Interleukin-6; Intermediate Filaments; Intermittent Claudication; Intestine, Small; Iridoid Glucosides; Iridoids; Iron; Isomerism; Isotope Labeling; Isoxazoles; Itraconazole; Kelch-Like ECH-Associated Protein 1; Ketoprofen; Kidney Failure, Chronic; Kinetics; Klebsiella pneumoniae; Lactams, Macrocyclic; Lactobacillus; Lactulose; Lakes; Lamivudine; Laparoscopy; Laparotomy; Laryngoscopy; Leucine; Limit of Detection; Linear Models; Lipid A; Lipopolysaccharides; Listeria monocytogenes; Liver; Liver Cirrhosis; Logistic Models; Longitudinal Studies; Losartan; Low Back Pain; Lung; Lupinus; Lupus Erythematosus, Systemic; Machine Learning; Macular Degeneration; Madin Darby Canine Kidney Cells; Magnetic Phenomena; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetics; Malaria, Falciparum; Male; Mannans; MAP Kinase Signaling System; Mass Spectrometry; Melatonin; Membrane Glycoproteins; Membrane Proteins; Meniscectomy; Menisci, Tibial; Mephenytoin; Mesenchymal Stem Cells; Metal Nanoparticles; Metal-Organic Frameworks; Methionine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Mice, Obese; Mice, Transgenic; Microbial Sensitivity Tests; Microcirculation; MicroRNAs; Microscopy, Video; Microtubules; Microvascular Density; Microwaves; Middle Aged; Minimally Invasive Surgical Procedures; Models, Animal; Models, Biological; Models, Molecular; Models, Theoretical; Molecular Docking Simulation; Molecular Structure; Molecular Weight; Morus; Mouth Floor; Multicenter Studies as Topic; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Muscle, Skeletal; Myocardial Ischemia; Myocardium; NAD; NADP; Nanocomposites; Nanoparticles; Naphthols; Nasal Lavage Fluid; Nasal Mucosa; Neisseria meningitidis; Neoadjuvant Therapy; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasms, Experimental; Neural Stem Cells; Neuroblastoma; Neurofilament Proteins; Neurogenesis; Neurons; New York; NF-E2-Related Factor 2; NF-kappa B; Nicotine; Nitriles; Nitrogen; Nitrogen Fixation; North America; Observer Variation; Occupational Exposure; Ochrobactrum; Oils, Volatile; Olea; Oligosaccharides; Omeprazole; Open Field Test; Optimism; Oregon; Oryzias; Osmolar Concentration; Osteoarthritis; Osteoblasts; Osteogenesis; Ovarian Neoplasms; Ovariectomy; Oxadiazoles; Oxidation-Reduction; Oxidative Stress; Oxygen; Ozone; p38 Mitogen-Activated Protein Kinases; Pakistan; Pandemics; Particle Size; Particulate Matter; Patient-Centered Care; Pelargonium; Peptides; Perception; Peripheral Arterial Disease; Peroxides; Pets; Pharmaceutical Preparations; Pharmacogenetics; Phenobarbital; Phenols; Phenotype; Phosphates; Phosphatidylethanolamines; Phosphines; Phospholipids; Phosphorus; Phosphorylation; Photoacoustic Techniques; Photochemotherapy; Photosensitizing Agents; Phylogeny; Phytoestrogens; Pilot Projects; Plant Components, Aerial; Plant Extracts; Plant Immunity; Plant Leaves; Plant Oils; Plants, Medicinal; Plasmodium berghei; Plasmodium falciparum; Platelet Activation; Platelet Function Tests; Pneumonia, Viral; Poaceae; Pogostemon; Poloxamer; Poly I; Poly(ADP-ribose) Polymerase Inhibitors; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins; Polycyclic Compounds; Polyethylene Glycols; Polylysine; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Population Dynamics; Portasystemic Shunt, Transjugular Intrahepatic; Positron Emission Tomography Computed Tomography; Postoperative Complications; Postprandial Period; Potassium Cyanide; Predictive Value of Tests; Prefrontal Cortex; Pregnancy; Prepulse Inhibition; Prevalence; Procalcitonin; Prodrugs; Prognosis; Progression-Free Survival; Proline; Proof of Concept Study; Prospective Studies; Protein Binding; Protein Conformation; Protein Domains; Protein Folding; Protein Multimerization; Protein Sorting Signals; Protein Structure, Secondary; Proton Pump Inhibitors; Protozoan Proteins; Psychometrics; Pulse Wave Analysis; Pyridines; Pyrrolidines; Quality of Life; Quantum Dots; Quinoxalines; Quorum Sensing; Radiopharmaceuticals; Rain; Random Allocation; Randomized Controlled Trials as Topic; Rats; Rats, Sprague-Dawley; Rats, Wistar; RAW 264.7 Cells; Reactive Oxygen Species; Receptor, Angiotensin, Type 1; Receptor, PAR-1; Receptors, CXCR4; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Interleukin-1; Receptors, Interleukin-17; Receptors, Notch; Recombinant Fusion Proteins; Recombinant Proteins; Reducing Agents; Reflex, Startle; Regional Blood Flow; Regression Analysis; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Tract Diseases; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Risk Assessment; Risk Factors; Rituximab; RNA, Messenger; RNA, Ribosomal, 16S; ROC Curve; Rosmarinic Acid; Running; Ruthenium; Rutin; Sarcolemma; Sarcoma; Sarcopenia; Sarcoplasmic Reticulum; SARS-CoV-2; Scavenger Receptors, Class A; Schools; Seasons; Seeds; Sequence Analysis, DNA; Severity of Illness Index; Sex Factors; Shock, Cardiogenic; Short Chain Dehydrogenase-Reductases; Signal Transduction; Silver; Singlet Oxygen; Sinusitis; Skin; Skin Absorption; Small Molecule Libraries; Smoke; Socioeconomic Factors; Soil; Soil Microbiology; Solid Phase Extraction; Solubility; Solvents; Spain; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Speech; Speech Perception; Spindle Poles; Spleen; Sporothrix; Staphylococcal Infections; Staphylococcus aureus; Stereoisomerism; Stomach Neoplasms; Stress, Physiological; Stroke Volume; Structure-Activity Relationship; Substrate Specificity; Sulfonamides; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Rate; T-Lymphocytes, Cytotoxic; Tandem Mass Spectrometry; Temperature; Tenofovir; Terpenes; Tetracycline; Tetrapleura; Textiles; Thermodynamics; Thiobarbituric Acid Reactive Substances; Thrombin; Thyroid Hormones; Thyroid Neoplasms; Tibial Meniscus Injuries; Time Factors; Tissue Distribution; Titanium; Toluidines; Tomography, X-Ray Computed; Tooth; Tramadol; Transcription Factor AP-1; Transcription, Genetic; Transfection; Transgender Persons; Translations; Treatment Outcome; Triglycerides; Ubiquinone; Ubiquitin-Specific Proteases; United Kingdom; United States; Up-Regulation; Vascular Stiffness; Veins; Ventricular Remodeling; Viral Load; Virulence Factors; Virus Replication; Vitis; Voice; Voice Quality; Wastewater; Water; Water Pollutants, Chemical; Water-Electrolyte Balance; Weather; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Young Adult; Zoogloea | 2022 |
1 trial(s) available for quinoxalines and oxadiazoles
845 other study(ies) available for quinoxalines and oxadiazoles
| Article | Year |
|---|---|
AMPA/kainic acid glutamate receptor antagonism in the zona incerta dorsal to the subthalamic nucleus inhibits amphetamine-induced stereotypy bur not locomotor activity.
Topics: Animals; Dextroamphetamine; Diencephalon; Ibotenic Acid; Kainic Acid; Lidocaine; Male; Microinjections; Motor Activity; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter; Stereotyped Behavior; Thalamus | 1992 |
NBQX, an AMPA antagonist, reduces glutamate-mediated brain edema.
Topics: Animals; Blood Pressure; Blood-Brain Barrier; Brain; Brain Edema; Glutamates; Glutamic Acid; Hematocrit; Male; Oxadiazoles; Protamines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Neurotransmitter; Serum Albumin | 1992 |
Characterization of functional interactions of imidazoquinoxaline derivatives with benzodiazepine-gamma-aminobutyric acidA receptors.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Chloride Channels; Chlorides; Chlorine; Cloning, Molecular; Drug Interactions; Electrophysiology; Flunitrazepam; GABA-A Receptor Antagonists; Kinetics; Male; Membrane Proteins; Models, Chemical; Molecular Conformation; Oxadiazoles; Quinoxalines; Radioisotopes; Rats; Rats, Inbred Strains; Receptors, GABA-A; Structure-Activity Relationship; Synaptosomes; Tritium | 1992 |
Utility of the parent-neutral loss scan screening technique: partial characterization of urinary metabolites of U-78875 in monkey urine.
Topics: Animals; Anti-Anxiety Agents; Chromatography, High Pressure Liquid; Haplorhini; Humans; Mass Spectrometry; Oxadiazoles; Quinoxalines | 1992 |
Characterization and regulation of a high affinity [3H]CNQX labelled AMPA receptor in rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Male; Muscimol; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Neurotransmitter; Tritium | 1992 |
Progress report from the Testing Program for Stimulant and Depressant Drugs (1991).
Topics: Animals; Anti-Anxiety Agents; Central Nervous System Depressants; Central Nervous System Stimulants; Discrimination, Psychological; Female; Flunitrazepam; Humans; Macaca mulatta; Male; Mice; Nitrazepam; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Self Administration; Substance-Related Disorders | 1992 |
Phospholipase A2-induced changes in AMPA receptor: an autoradiographic study.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Ibotenic Acid; Male; Oxadiazoles; Phospholipases A; Phospholipases A2; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Neurotransmitter; Tritium | 1992 |
Role of calcium in regulation of phosphoinositide signaling pathway.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Carbachol; Cations, Divalent; Cells, Cultured; Cerebral Cortex; Diltiazem; Egtazic Acid; Inositol; Inositol Phosphates; Isradipine; Kinetics; Models, Neurological; Neurons; Oxadiazoles; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Rats; Signal Transduction; Sulfonamides; Verapamil | 1991 |
Delayed AMPA receptor blockade reduces cerebral infarction induced by focal ischemia.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebral Infarction; Cerebrovascular Circulation; Ischemic Attack, Transient; Male; Oxadiazoles; Oxygen; Partial Pressure; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, AMPA; Receptors, Neurotransmitter | 1991 |
Behavioral effects of U-78875, a quinoxalinone anxiolytic with potent benzodiazepine antagonist activity.
Topics: Animals; Anti-Anxiety Agents; Avoidance Learning; Behavior, Animal; Diazepam; Electroencephalography; Flumazenil; Injections, Intraperitoneal; Male; Motor Activity; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred F344 | 1991 |
Role of cGMP in the mechanism of anxiolytic activity of U-78875.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain Chemistry; Carbolines; Cerebellum; Convulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Electroshock; Flunitrazepam; Male; Mice; Muscimol; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Stress, Psychological | 1991 |
Determination of 6-chloro-3-(3-cyclopropyl 1,2,4-oxadiazol-5-yl)-5-methyl-imidazo less than 1,5-a greater than-quinoxalin-4(5h)-one in rat serum, urine and brain by solid-phase extraction and liquid chromatography.
Topics: Animals; Biological Availability; Brain Chemistry; Bridged Bicyclo Compounds; Chromatography, High Pressure Liquid; Male; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
Autoradiographic characterization and localization of quisqualate binding sites in rat brain using the antagonist [3H]6-cyano-7-nitroquinoxaline-2,3-dione: comparison with (R,S)-[3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding sites.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; Oxadiazoles; Oxazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Glutamate receptors activate Ca2+ mobilization and Ca2+ influx into astrocytes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Benzofurans; Brain; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Fluorescent Dyes; Fura-2; Glutamates; Hippocampus; Ibotenic Acid; Nickel; Nimodipine; Organ Specificity; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
A slight anticonvulsant effect of CNQX and DNQX as measured by homocysteine- and quisqualate-induced seizures.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anticonvulsants; Female; Homocysteine; Mice; Oxadiazoles; Quinoxalines; Quisqualic Acid; Seizures | 1990 |
Contribution of quisqualate/kainate and NMDA receptors to excitatory synaptic transmission in the rat's visual cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Electrophysiology; Evoked Potentials; Kainic Acid; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, AMPA; Receptors, Cell Surface; Receptors, Kainic Acid; Receptors, Neurotransmitter; Visual Cortex | 1990 |
Determination of 3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-5-(1-methylethyl)imidazo[1, 5-a]quinoxalin-4(5H)-one in serum by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Oxadiazoles; Quinoxalines | 1991 |
2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Ischemia; Cerebral Cortex; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter | 1990 |
6,7-Dinitroquinoxaline-2,3-dione blocks the cytotoxicity of N-methyl-D-aspartate and kainate, but not quisqualate, in cortical cultures.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Hippocampus; Kainic Acid; Ligands; N-Methylaspartate; Neurotoxins; Norepinephrine; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Antagonism of monosynaptic excitations in the mouse olfactory cortex slice by 6,7-dinitroquinoxaline-2,3-dione.
Topics: Animals; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Male; Mice; N-Methylaspartate; Oxadiazoles; Pyramidal Tracts; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Reflex, Monosynaptic; Synapses; Synaptic Transmission; Valine | 1989 |
6-Cyano-7-nitroquinoxaline-2,3-dione as an excitatory amino acid antagonist in area CA1 of rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Female; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; N-Methylaspartate; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Synapses | 1989 |
L-alpha-aminodipate antagonizes the priming effect of quisqualate in hippocampal slices.
Topics: 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids, Dicarboxylic; Animals; Hippocampus; In Vitro Techniques; Male; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains | 1989 |
Two distinct quisqualate receptors regulate Ca2+ homeostasis in hippocampal neurons in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Calcium Channels; Glutamates; Glutamic Acid; Hippocampus; Homeostasis; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Mice; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Neurotransmitter; Synapses | 1989 |
Quisqualate neurotoxicity: a delayed, CNQX-sensitive process triggered by a CNQX-insensitive mechanism in young rat hippocampal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Hippocampus; In Vitro Techniques; Kynurenic Acid; Membrane Potentials; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Neurotransmitter | 1989 |
Quantitative physiological characterization of a quinoxalinedione non-NMDA receptor antagonist.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Hippocampus; Kainic Acid; Mathematics; N-Methylaspartate; Neurons; Oxadiazoles; Quinoxalines; Quisqualic Acid; Synapses | 1989 |
Non-NMDA glutamate receptor antagonist 3H-CNOX binds with equal affinity to two agonist states of quisqualate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Cerebral Cortex; Glutamates; Ibotenic Acid; In Vitro Techniques; Molecular Weight; Oxadiazoles; Protein Conformation; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Neurotransmitter; Temperature | 1989 |
Effects of new non-N-methyl-D-aspartate antagonists on synaptic transmission in the in vitro rat hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission | 1989 |
Two pharmacological classes of quisqualate-induced electrical responses in rat retinal ganglion cells in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Kynurenic Acid; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Retina; Retinal Ganglion Cells | 1989 |
Excitation of hippocampal neurons by stimulation of glutamate Qp receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurons; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Muscarinic; Receptors, Neurotransmitter | 1989 |
New quinoxalinediones show potent antagonism of quisqualate responses in cultured mouse cortical neurons.
Topics: Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Receptors, AMPA; Receptors, Drug; Sodium | 1988 |
6,7-Dichloro-3-hydroxy-2-quinoxalinecarboxylic acid is a relatively potent antagonist at NMDA and kainate receptors.
Topics: Animals; Biological Assay; Hippocampus; In Vitro Techniques; Kainic Acid; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
A new and specific non-NMDA receptor antagonist, FG 9065, blocks L-AP4-evoked depolarization in rat cerebral cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aminobutyrates; Animals; Aspartic Acid; Cerebral Cortex; Evoked Potentials; In Vitro Techniques; N-Methylaspartate; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter | 1988 |
CNQX blocks acidic amino acid induced depolarizations and synaptic components mediated by non-NMDA receptors in rat hippocampal slices.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Female; Hippocampus; Ibotenic Acid; Kainic Acid; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1988 |
Blockade of excitatory synaptic transmission by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) in the hippocampus in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Aspartic Acid; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Male; N-Methylaspartate; Neural Inhibition; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Synaptic Transmission | 1988 |
Quinoxalinediones selectively block quisqualate and kainate receptors and synaptic events in rat neocortex and hippocampus and frog spinal cord in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anura; Cerebral Cortex; Electric Stimulation; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Kainic Acid; Neuromuscular Depolarizing Agents; Oxadiazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Kainic Acid; Receptors, Neurotransmitter; Spinal Cord; Synapses | 1988 |
Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release.
Topics: Aminopyridines; Animals; Brimonidine Tartrate; Cadmium; Calcium Channel Blockers; Dioxanes; Hippocampus; Idazoxan; In Vitro Techniques; Mollusk Venoms; Neomycin; Nicotinic Acids; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Phorbol Esters; Quinoxalines; Rabbits | 1988 |
U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes.
Topics: Animals; Avoidance Learning; Benzodiazepines; Discrimination Learning; Ethanol; Female; Hypnotics and Sedatives; Macaca mulatta; Male; Mice; Motor Activity; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred F344; Receptors, GABA; Recombinant Proteins; Substance-Related Disorders | 1995 |
Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion.
Topics: Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Swine; Terpenes; Thapsigargin | 1995 |
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Cattle; Cells, Cultured; Cerebellum; Cyclic GMP; Guanylate Cyclase; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 1995 |
Induction of a hepatic toxic syndrome in the Dutch-belted rabbit by a quinoxalinone anxiolytic.
Topics: Animals; Anti-Anxiety Agents; DNA; Fatty Liver; Female; Liver Glycogen; Oxadiazoles; Proteins; Quinoxalines; Rabbits; Statistics as Topic | 1995 |
The use of liquid chromatography/thermospray mass spectrometry with on-line ultraviolet diode array and radiochemical detection: characterization of the putative metabolites of U-78875 in female rat faeces.
Topics: Animals; Anti-Anxiety Agents; Biotransformation; Chromatography, Liquid; Feces; Female; Mass Spectrometry; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet | 1994 |
Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice.
Topics: Animals; Body Temperature; Drug Antagonism; GABA-A Receptor Antagonists; Male; Mice; Oxadiazoles; Quinoxalines; Receptors, GABA-A | 1993 |
Application of solid-phase extraction in the determination of U-82217 in rat serum, urine and brain.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Chromatography, Liquid; Hypnotics and Sedatives; Oxadiazoles; Quinoxalines; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1993 |
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Topics: Animals; Anxiety; Benzodiazepines; Binding, Competitive; Brain; Bridged Bicyclo Compounds, Heterocyclic; Chlorides; Flunitrazepam; GABA Agonists; GABA Antagonists; Molecular Conformation; Molecular Structure; Oxadiazoles; Pentylenetetrazole; Quinoxalines; Rats; Receptors, GABA-A | 1996 |
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Lip; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Solubility | 1995 |
Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Pulmonary Artery; Quinoxalines; S-Nitrosoglutathione; Swine; Vasodilation | 1996 |
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.
Topics: Animals; Blood Platelets; Cyclic GMP; Cytosol; Enzyme Inhibitors; Epoprostenol; Guanylate Cyclase; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Oxadiazoles; Oxyhemoglobins; Platelet Aggregation; Quinoxalines; Rats; Vasodilation | 1996 |
Potentiation of hypoxic injury in cultured rabbit hepatocytes by the quinoxalinone anxiolytic, panadiplon.
Topics: Adenosine Triphosphate; Animals; Anti-Anxiety Agents; Cell Death; Cell Hypoxia; Cells, Cultured; Dihydroxyacetone; Drug Synergism; Female; Glycogen; L-Lactate Dehydrogenase; Liver; Oxadiazoles; Oxygen; Pyruvates; Pyruvic Acid; Quinoxalines; Rabbits | 1996 |
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
Topics: Animals; Binding Sites; Cattle; Enzyme Inhibitors; Guanylate Cyclase; Heme; Kinetics; Lung; Nitric Oxide; Oxadiazoles; Quinoxalines; Spectrophotometry | 1996 |
Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase.
Topics: Animals; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Rabbits; Solubility; Synaptic Transmission | 1996 |
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one reverses the inhibition by sodium nitroprusside of thrombin-induced platelet aggregation in the rat.
Topics: Animals; Drug Antagonism; Enzyme Inhibitors; Male; Nitroprusside; Oxadiazoles; Platelet Aggregation; Quinoxalines; Rats; Rats, Wistar; Thrombin; Vasodilator Agents | 1996 |
The nitric oxide-cyclic GMP pathway and synaptic plasticity in the rat superior cervical ganglion.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Glutathione; Guanylate Cyclase; Male; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Synaptic Transmission | 1996 |
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Guanylate Cyclase; Hippocampus; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine | 1996 |
Long-term depression in rat cerebellum requires both NO synthase and NO-sensitive guanylyl cyclase.
Topics: Animals; Cerebellum; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Solubility | 1996 |
Inhibitory transmission to the longitudinal muscle of the mouse caecum is mediated largely by nitric oxide acting via soluble guanylyl cyclase.
Topics: Animals; Cecum; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Histocytochemistry; Immunohistochemistry; Mice; Mice, Inbred DBA; Muscle Relaxation; Muscle, Smooth; NADPH Dehydrogenase; Neural Inhibition; Neurotransmitter Agents; Nitric Oxide; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Solubility; Vasodilator Agents | 1996 |
Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease.
Topics: 1-Methyl-3-isobutylxanthine; Apolipoproteins E; Arginine; Blood Platelets; Cholesterol; Cyclic AMP; Cyclic GMP; Dimyristoylphosphatidylcholine; Enzyme Inhibitors; Guanylate Cyclase; Humans; Lipoproteins, HDL; Membrane Lipids; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines | 1997 |
Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15.
Topics: Alkaloids; Animals; Apoptosis; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Indoles; Islets of Langerhans; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione | 1997 |
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
Topics: Animals; Aorta; COS Cells; Cyclic GMP; Guanosine Triphosphate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Oxidation-Reduction; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
The effect of the vasodilator nicotinamide on cyclic nucleotide pathways in vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Imines; In Vitro Techniques; Muscle, Smooth, Vascular; Niacinamide; Oxadiazoles; Phenylephrine; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Rats, Wistar; Second Messenger Systems; Vasodilation; Vasodilator Agents | 1997 |
Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles.
Topics: Acetylcholine; Animals; Arterioles; Cerebrovascular Circulation; Drug Combinations; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Mice, Inbred ICR; Nitroprusside; Oxadiazoles; Quinoxalines; Superoxide Dismutase; Vasodilation; Vasodilator Agents | 1997 |
Endogenous nitric oxide limits cytokine-induced damage of murine lung epithelial cells.
Topics: Animals; Arginine; Cytokines; Drug Combinations; Enzyme Inhibitors; Epithelium; Ethidium; Glutathione; Guanylate Cyclase; Interferon-gamma; Interleukin-1; Lung; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Stimulation of mucin exocytosis from human epithelial cells by nitric oxide: evidence for a cGMP-dependent and a cGMP-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Cyclic GMP; Cysteine; Enzyme Inhibitors; Epithelium; Exocytosis; Guanylate Cyclase; Humans; Hydrazines; Mucins; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Reactive Oxygen Species; Superoxide Dismutase | 1997 |
Evidence that NO acts as a redundant NANC inhibitory neurotransmitter in the guinea-pig isolated taenia coli.
Topics: Adenosine Triphosphate; Animals; Apamin; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Intestines; Male; Neurotransmitter Agents; Nifedipine; Nitric Oxide; Nitroarginine; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Quinoxalines | 1997 |
Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: a comparison with other species.
Topics: Animals; Electric Stimulation; Guanethidine; Humans; Male; Mice; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Oxyhemoglobins; Penis; Quinoxalines; Rabbits; Rats; Species Specificity; Sympathetic Nervous System | 1997 |
Nitric oxide activates chloride currents in human lung epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Cell Line; Chloride Channels; Enzyme Inhibitors; Epithelium; Glutathione; Humans; Lung; Membrane Potentials; Nitric Oxide; Nitroso Compounds; omega-N-Methylarginine; Oxadiazoles; Patch-Clamp Techniques; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 1997 |
Nitric-oxide-guanylyl-cyclase-dependent and -independent components of multiple forms of long-term synaptic depression.
Topics: Animals; Cyclic GMP; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Niacinamide; Nitric Oxide; Organ Culture Techniques; Oxadiazoles; Penicillamine; Platelet Aggregation Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Synapses; Thionucleotides | 1997 |
Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitrosoglutathione; Time Factors | 1997 |
Laminar analysis of activity-dependent increases of CBF in rat cerebellar cortex: dependence on synaptic strength.
Topics: Analysis of Variance; Animals; Cerebellar Cortex; Cerebrovascular Circulation; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Harmaline; Nerve Fibers; Neurons; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Regional Blood Flow; Synapses; Ultrasonography, Doppler, Transcranial | 1997 |
Glutathione causes coronary vasodilation via a nitric oxide- and soluble guanylate cyclase-dependent mechanism.
Topics: Analysis of Variance; Animals; Blood Pressure; Carmustine; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Glyburide; Guanylate Cyclase; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Superoxide Dismutase; Vasodilation; Ventricular Function, Left | 1997 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ) inhibits relaxation of rabbit aortic rings induced by carbon monoxide, nitric oxide, and glyceryl trinitrate.
Topics: Animals; Aorta; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Oxadiazoles; Quinoxalines; Rabbits | 1997 |
Nitric oxide inhibits the dopamine-induced K+ current via guanylate cyclase in Aplysia neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Cyclic GMP; Dopamine; Enzyme Inhibitors; Ganglia, Invertebrate; Guanylate Cyclase; Hemoglobins; Hydroxylamine; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Quinoxalines | 1997 |
A potential role of cyclic GMP in the regulation of lordosis behavior of female rats.
Topics: Animals; Cerebellum; Cerebral Ventricles; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hypothalamus; Injections, Intraventricular; Nitric Oxide; Organ Culture Techniques; Oxadiazoles; Posture; Quinoxalines; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal | 1997 |
Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide.
Topics: Animals; Aorta; Carbon Monoxide; Cell Nucleus; Cells, Cultured; Cyclic GMP; Dactinomycin; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oligonucleotide Probes; Oxadiazoles; Quinoxalines; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Spermine; Transcription, Genetic | 1997 |
Effects of a novel guanylate cyclase inhibitor on nitric oxide-dependent inhibitory neurotransmission in canine proximal colon.
Topics: Animals; Colon; Cyclic GMP; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines | 1997 |
Tetrahydrobiopterin modulates cyclooxygenase-2 expression in human mesangial cells.
Topics: Biopterins; Cells, Cultured; Cyclooxygenase 2; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Humans; Interleukin-1; Isoenzymes; Membrane Proteins; Methotrexate; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Pteridines; Pterins; Quinoxalines; Recombinant Proteins; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 1997 |
Cyclic guanosine 3',5'-monophosphate-mediated neuroprotection by nitric oxide in dissociated cultures of rat dorsal root ganglion neurones.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Spinal; Guanylate Cyclase; Male; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 1997 |
Effect of selective inhibition of soluble guanylyl cyclase on the K(Ca) channel activity in coronary artery smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Iloprost; In Vitro Techniques; Kinetics; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitroso Compounds; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channels; Quinoxalines; Scorpion Venoms; Vasodilation | 1998 |
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Proteins; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleotides, Cyclic; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Sensitivity and Specificity; Sulfonamides; Uterine Contraction; Uterus; Vanadates; Vasodilator Agents; Virulence Factors, Bordetella | 1998 |
Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium.
Topics: Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Guanylate Cyclase; Lymphokines; Mitogen-Activated Protein Kinase Kinases; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Protein Kinase Inhibitors; Quinoxalines; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1998 |
Nitric oxide-sensitive guanylyl cyclase inhibits acetylcholine release and excitatory motor transmission in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Depression, Chemical; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Ileum; Indazoles; Male; Motor Neurons; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Synaptic Transmission | 1998 |
Localization of heme oxygenase-2 immunoreactivity to parasympathetic ganglia of human and guinea-pig airways.
Topics: Animals; Atropine; Carbon Monoxide; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Parasympathetic; Ganglionic Blockers; Guanylate Cyclase; Guinea Pigs; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Muscarinic Antagonists; Muscle Contraction; Oxadiazoles; Protoporphyrins; Quinoxalines; Receptors, Cholinergic; Respiratory Physiological Phenomena; Respiratory System; Synaptic Transmission; Trimethaphan; Vagus Nerve | 1998 |
Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase.
Topics: Acetylcholine; Animals; Carotid Arteries; Endothelium, Vascular; Enzyme Inhibitors; Gene Deletion; Gene Targeting; Heterozygote; Homozygote; Mice; Mice, Mutant Strains; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Vasodilator Agents | 1998 |
Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.
Topics: Alkaloids; Animals; Blood Pressure; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hypertension, Pulmonary; Indoles; Lung; Male; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Circulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Thionucleotides; Vascular Resistance; Vasoconstriction | 1998 |
Blockade of nitrergic neuroeffector transmission in guinea-pig colon by a selective inhibitor of soluble guanylyl cyclase.
Topics: Animals; Colon; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Solubility; Synaptic Transmission | 1998 |
Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cyclic IMP; Enzyme Activation; Enzyme Inhibitors; Nitric Oxide; Nitroprusside; Oligopeptides; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Retina; Sulfhydryl Reagents | 1998 |
Nerve-induced release of nitric oxide exerts dual effects on nicotinic transmission within the coeliac ganglion in the rabbit.
Topics: Animals; Arginine; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia; Ganglia, Sympathetic; Male; Neurons; NG-Nitroarginine Methyl Ester; Nicotine; Nitric Oxide; Nitroarginine; Oxadiazoles; Quinoxalines; Rabbits; Splanchnic Nerves; Synapses; Synaptic Transmission; Time Factors | 1998 |
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Uridine Triphosphate | 1998 |
Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Animals; Benzoates; Carbazoles; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Long-Term Potentiation; Neurons; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinases; Purinones; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1998 |
Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cyclic GMP; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Fetus; Guanylate Cyclase; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; Oxadiazoles; Quinoxalines; Rats; Solubility | 1998 |
Dissociation between electrical and mechanical responses to nitrergic stimulation in the canine gastric fundus.
Topics: Animals; Arginine; Atropine; Calcium; Cytosol; Dogs; Electric Stimulation; Female; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Nicardipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Phentolamine; Propranolol; Quaternary Ammonium Compounds; Quinoxalines; Stomach; Synaptic Transmission; Time Factors | 1998 |
Involvement of bradykinin B1 and B2 receptors in relaxation of mouse isolated trachea.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Trachea | 1998 |
A transient dilatation of pressurised rat cerebral arteries during rapid pressure increases is mediated by nitric oxide.
Topics: Aminoquinolines; Animals; Arginine; Blood Pressure; Cerebral Arteries; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Temperature; Vasodilation | 1998 |
Cardioprotection by activation of NO/cGMP pathway after cardioplegic arrest and 8-hour storage.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Cryopreservation; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Arrest, Induced; Heart Transplantation; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardium; Nitric Oxide; Nitroprusside; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vasodilator Agents; Ventricular Function, Left | 1998 |
Nitric oxide-mediated cGMP production in the islands of Calleja in the rat.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Olfactory Bulb; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Lew; Tissue Distribution | 1998 |
Nitric oxide donors inhibit the acetylcholine-induced Cl- current in identified Onchidium neurons.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Chlorides; Cyclic GMP; Diethylamines; Electric Conductivity; Enzyme Inhibitors; Hemoglobins; Mollusca; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines | 1998 |
Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione.
Topics: Cell Membrane; Cyclic AMP; Cyclic GMP; Glutathione; Humans; Hydrazines; In Vitro Techniques; Nitric Oxide; Nitrogen Oxides; Nitroso Compounds; Oxadiazoles; Phenanthrolines; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; Sulfhydryl Compounds | 1998 |
Soluble guanylate cyclase in Saccharomyces cerevisiae.
Topics: Cyclic GMP; Enzyme Stability; Guanylate Cyclase; Nitroprusside; Oxadiazoles; Precipitin Tests; Quinoxalines; Saccharomyces cerevisiae; Solubility | 1998 |
Galanin stimulates the N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in vivo in the rat ventral hippocampus.
Topics: Animals; Cyclic GMP; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Galanin; Hippocampus; Locomotion; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peptide Fragments; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1998 |
Modulation of angiotensin-converting enzyme by nitric oxide.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Carotid Arteries; Diethylamines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Male; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Oligopeptides; Oxadiazoles; Peptidyl-Dipeptidase A; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley | 1998 |
Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice.
Topics: Animals; Astrocytes; Cerebellum; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Mice; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Norepinephrine; Oxadiazoles; Prazosin; Quinoxalines; Sympatholytics; Sympathomimetics | 1998 |
Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo.
Topics: Animals; Basilar Artery; Enzyme Inhibitors; Guanylate Cyclase; Male; Nitric Oxide; Nitroarginine; Oligopeptides; Osmolar Concentration; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Receptors, Thrombin; Time Factors; Trypsin; Vasodilation | 1998 |
Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Epilepsy; Excitatory Postsynaptic Potentials; Fluoxetine; Hippocampus; In Vitro Techniques; Ketanserin; Male; Membrane Potentials; Metergoline; Neurons; Oxadiazoles; Picrotoxin; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission; Tryptamines | 1998 |
Nitrergic relaxation of the horse corpus cavernosum. Role of cGMP.
Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Horses; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NADPH Dehydrogenase; Nerve Fibers; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Potassium Channels; Quinoxalines; Tetrodotoxin | 1998 |
Evidence for the involvement of nitric oxide in the inhibitory effect of GSPYFVamide on Helix aspersa central neurones.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Helix, Snails; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oligopeptides; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitrosoglutathione; Sodium Nitrite | 1998 |
Nitric oxide signaling in pain and nociceptor sensitization in the rat.
Topics: Animals; Dinoprostone; Enzyme Inhibitors; Guanylate Cyclase; Hyperalgesia; Male; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin Receptor Agonists; Signal Transduction; Tetrodotoxin | 1998 |
Modulation of relaxation to levcromakalim by S-nitroso-N-acetylpenicillamine (SNAP) and 8-bromo cyclic GMP in the rat isolated mesenteric artery.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cromakalim; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Relaxation; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine | 1998 |
Influence of a selective guanylate cyclase inhibitor, and of the contraction level, on nitrergic relaxations in the gastric fundus.
Topics: Animals; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 1998 |
Phosphodiesterase inhibitors suppress alpha2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Enzyme Inhibitors; Epithelium; Female; Male; Oxadiazoles; Phenylephrine; Phosphodiesterase Inhibitors; Quinoxalines; Rabbits; Receptors, Adrenergic, beta-2; Serotonin; Trachea | 1998 |
Functional properties of a naturally occurring isoform of soluble guanylyl cyclase.
Topics: Animals; Chromatography, Affinity; Enzyme Inhibitors; Guanylate Cyclase; Heme; Humans; Indazoles; Isoenzymes; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Placenta; Polymerase Chain Reaction; Quinoxalines; Solubility; Spodoptera | 1998 |
Nitric oxide-independent activation of soluble guanylyl cyclase contributes to endotoxin shock in rats.
Topics: Animals; Aorta; Blood Pressure; Charybdotoxin; Dexamethasone; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Escherichia coli; Guanidines; Guanylate Cyclase; Heart Rate; In Vitro Techniques; Lipopolysaccharides; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Tetraethylammonium | 1998 |
Nitric oxide inhibits aldosterone synthesis by a guanylyl cyclase-independent effect.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Bacterial Toxins; Cattle; Cells, Cultured; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Pregnenolone; Quinoxalines; Zona Glomerulosa | 1998 |
Role of endothelial carbon monoxide in attenuated vasoreactivity following chronic hypoxia.
Topics: Animals; Aorta, Thoracic; Arsenites; Carbon Monoxide; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hypoxia; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroarginine; Oxadiazoles; Penicillamine; Phenylephrine; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Reference Values; S-Nitroso-N-Acetylpenicillamine; Sodium Compounds | 1998 |
NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms.
Topics: Animals; Aorta; Arginase; Arginine; Caco-2 Cells; Cell Division; Coculture Techniques; DNA; Endothelium, Vascular; Humans; Nitric Oxide; Nitric Oxide Donors; Ornithine; Ornithine Decarboxylase; Oxadiazoles; Polyamines; Putrescine; Quinoxalines; Rats; Spermidine; Spermine; Thymidine; Triazenes; Urea | 1998 |
In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Male; Mutagens; Nitric Oxide; Nitrogen Oxides; Nitroglycerin; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; Spermine; Vasodilation; Vasodilator Agents | 1998 |
Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
Topics: Animals; Aorta; Cells, Cultured; Citrulline; Cyclic GMP; Dexamethasone; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polysaccharides; Potassium Channels; Purinones; Quinoxalines; Rabbits | 1998 |
Cyclic AMP mediates endothelial protection by nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1998 |
Evidence for NO. redox form of nitric oxide as nitrergic inhibitory neurotransmitter in gut.
Topics: Aminoquinolines; Animals; Apamin; Chloride Channels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Agents; Niflumic Acid; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; ortho-Aminobenzoates; Oxadiazoles; Oxidation-Reduction; Potassium Channel Blockers; Quinoxalines | 1998 |
Involvement of nitric oxide in the mediation of NANC inhibitory neurotransmission of guinea-pig trachea.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Male; Methemoglobin; Methylene Blue; Neural Inhibition; Nitric Oxide; Oxadiazoles; Quinoxalines; Receptors, Adrenergic; Receptors, Cholinergic; Synaptic Transmission; Trachea | 1998 |
Neuronal death induced by SIN-1 in the presence of superoxide dismutase: protection by cyclic GMP.
Topics: Animals; Cell Death; Cyclic GMP; Drug Synergism; Enzyme Inhibitors; Hydrogen Peroxide; Molsidomine; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents | 1998 |
Depletion of nitric oxide causes cell cycle alterations, apoptosis, and oxidative stress in pulmonary cells.
Topics: Animals; Apoptosis; Benzoates; Cell Cycle; Cells, Cultured; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Epithelial Cells; Fluoresceins; Guanylate Cyclase; Imidazoles; Lung; Nitric Oxide; Oxadiazoles; Oxidative Stress; Pleura; Quinoxalines; Rats | 1998 |
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
Topics: Animals; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Methylene Blue; Mice; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Solubility; Trachea; Vasodilator Agents | 1998 |
New 1,4-dihydropyridines conjugated to furoxanyl moieties, endowed with both nitric oxide-like and calcium channel antagonist vasodilator activities.
Topics: Animals; Aorta, Thoracic; Binding, Competitive; Calcium Channel Blockers; Cerebral Cortex; Dihydropyridines; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Structure-Activity Relationship; Vasodilator Agents | 1998 |
Disruption of mitochondrial activities in rabbit and human hepatocytes by a quinoxalinone anxiolytic and its carboxylic acid metabolite.
Topics: Adolescent; Adult; Animals; Anti-Anxiety Agents; Cell Respiration; Cells, Cultured; Child, Preschool; Cyclopropanes; Female; Fluorescent Dyes; Humans; Liver; Male; Middle Aged; Mitochondria, Liver; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rabbits; Rats; Rhodamine 123; Species Specificity | 1998 |
Nitrergic neurotransmission mediates the non-adrenergic non-cholinergic responses in the clitoral corpus cavernosum of the rabbit.
Topics: Animals; Arginine; Clitoris; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Purinones; Quinoxalines; Rabbits; Synaptic Transmission; Tetrodotoxin | 1998 |
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Manganese; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase C; Purinones; Quinoxalines; Rabbits; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Nitric oxide inhibits potassium transport in the rat distal colon.
Topics: Animals; Arginine; Biological Transport; Colon; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penicillamine; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine | 1999 |
Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study.
Topics: Animals; Blotting, Western; Carbon Monoxide; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Female; Glucose; Heme Oxygenase (Decyclizing); Hemin; Hormones; Immunohistochemistry; Islets of Langerhans; Mice; Mice, Inbred Strains; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Protoporphyrins; Quinoxalines | 1999 |
Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite.
Topics: Blood Platelets; Calcium; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Free Radical Scavengers; Guanylate Cyclase; Humans; Immunohistochemistry; Nitrates; Nitric Oxide; Oxadiazoles; Oxidants; Oxyhemoglobins; P-Selectin; Platelet Activation; Quinoxalines | 1998 |
Effects of endogenous and exogenous nitric oxide on endothelin-1 production in cultured vascular endothelial cells.
Topics: Animals; Aorta; Benzoates; Cells, Cultured; Cyclic GMP; Endothelin-1; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitro Compounds; Oxadiazoles; Protein Precursors; Quinoxalines; RNA, Messenger; Swine | 1999 |
Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Cyclic GMP; Cysteine; Fatty Acids, Unsaturated; Glutathione; Guanylate Cyclase; Humans; Hydrazines; Inhibitory Concentration 50; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Thromboxane A2 | 1999 |
Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Histones; In Vitro Techniques; Isoquinolines; Juxtaglomerular Apparatus; Kidney Medulla; Kinetics; Male; Microscopy, Video; Muscle, Smooth, Vascular; Nephrons; Norepinephrine; Oxadiazoles; Protein Kinases; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides; Vasodilation | 1999 |
Activation of particulate guanylyl cyclase by Vibrio vulnificus hemolysin.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Cell Membrane; Cholesterol; Cytosol; Drug Interactions; Enzyme Inhibitors; Female; Guanylate Cyclase; Hemolysin Proteins; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Polysaccharides; Quinoxalines; Rats; Rats, Sprague-Dawley; Vibrio | 1999 |
Role of nitric oxide production in carbachol-induced negative chronotropy in cultured rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Atropine; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Heart Ventricles; Methylene Blue; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 1999 |
Role of soluble guanylate cyclase in dilator responses of the cerebral microcirculation.
Topics: Acetylcholine; Adenosine; Animals; Brain; Cerebral Arteries; Cerebrovascular Circulation; Clotrimazole; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Fatty Acids, Unsaturated; Growth Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; Indazoles; Microcirculation; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Rabbits; Solubility; Vasodilation; Vasodilator Agents | 1999 |
Both protein kinase G dependent and independent mechanisms are involved in the modulation of glutamate release by nitric oxide in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; Animals; Calcium; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Nitric Oxide; Nitroprusside; Oxadiazoles; Presynaptic Terminals; Protein Kinases; Quinoxalines; Rats; Sulfhydryl Reagents; Synaptosomes; Thionucleotides | 1999 |
Nitric oxide and C-type atrial natriuretic peptide stimulate primary aortic smooth muscle cell migration via a cGMP-dependent mechanism: relationship to microfilament dissociation and altered cell morphology.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Actin Cytoskeleton; Angiotensin II; Animals; Aorta, Thoracic; Cell Movement; Cells, Cultured; Culture Media; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Diffusion Chambers, Culture; Guanylate Cyclase; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myosin Heavy Chains; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley | 1999 |
Possible novel mechanism for bitter taste mediated through cGMP.
Topics: Aminoquinolines; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Glycine Agents; Methylene Blue; Mice; Nitro Compounds; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; Signal Transduction; Strychnine; Sulfhydryl Reagents; Taste; Theophylline | 1999 |
Regulation of calcitonin gene-related peptide secretion by a serotonergic antimigraine drug.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Cells, Cultured; Colforsin; Cyclic AMP; HeLa Cells; Humans; Inflammation; Kinetics; Models, Neurological; Neurons; Okadaic Acid; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Recombinant Proteins; Serotonin Receptor Agonists; Sumatriptan; Transfection; Trigeminal Ganglion; Tryptamines | 1999 |
Inhibition by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) of responses to nitric oxide-donors in rat pulmonary artery: influence of the mechanism of nitric oxide generation.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Male; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitrogen Oxides; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; Spermine; Vasodilation | 1999 |
Inhibitory effect of 4-aminopyridine on responses of the basilar artery to nitric oxide.
Topics: 4-Aminopyridine; Acetylcholine; Adenosine Triphosphate; Animals; Basilar Artery; Cromakalim; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Papaverine; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1999 |
P2u receptor-mediated release of endothelium-derived relaxing factor/nitric oxide and endothelium-derived hyperpolarizing factor from cerebrovascular endothelium in rats.
Topics: 4-Aminopyridine; Animals; Apamin; Barium Compounds; Cerebral Arteries; Cerebrovascular Circulation; Charybdotoxin; Chlorides; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Peptides; Potassium Channels; Potassium Chloride; Quinoxalines; Rats; Rats, Long-Evans; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Tetraethylammonium; Uridine Triphosphate; Vasodilation | 1999 |
Nitric oxide stimulates cGMP production and mimics synaptic responses in metacerebral neurons of Aplysia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Aplysia; Cyclic GMP; Cysteine; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Ganglia, Invertebrate; Guanylate Cyclase; Immunohistochemistry; Neurons; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosothiols; Stimulation, Chemical | 1999 |
Regulation of neuronal growth cone filopodia by nitric oxide.
Topics: Animals; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Cones; Guanylate Cyclase; Hydrazines; Molsidomine; Mutagens; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Pseudopodia; Quinoxalines; Snails; Sulfhydryl Reagents | 1999 |
Effects of guanylyl cyclase and protein kinase G inhibitors on vasodilatation in non-tolerant and tolerant bovine coronary arteries.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Interactions; Drug Tolerance; Enzyme Inhibitors; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Penicillamine; Protein Kinase Inhibitors; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Vasodilation; Vasodilator Agents | 1999 |
The nitric oxide donors, SNAP and DEA/NO, exert a negative inotropic effect in rat cardiomyocytes which is independent of cyclic GMP elevation.
Topics: Animals; Cardiotonic Agents; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxidation-Reduction; Penicillamine; Quinoxalines; Rats; Rats, Wistar | 1999 |
L-arginine limits myocardial cell death secondary to hypoxia-reoxygenation by a cGMP-dependent mechanism.
Topics: Animals; Arginine; Cell Death; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hypoxia; L-Lactate Dehydrogenase; Male; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Oxadiazoles; Oxygen Consumption; Quinoxalines; Rats; Rats, Sprague-Dawley | 1999 |
Does potassium channel opening contribute to endothelium-dependent relaxation in human internal thoracic artery?
Topics: Aged; Carbachol; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Ion Channel Gating; Male; Middle Aged; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Potassium; Potassium Channels; Quinoxalines; Thoracic Arteries; Vasodilation; Vasodilator Agents | 1999 |
Drug discrimination analysis of partial agonists at the benzodiazepine site. I. Differential effects of U-78875 across training conditions in baboons and rats.
Topics: Acoustic Stimulation; Administration, Oral; Animals; Anti-Anxiety Agents; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA-A Receptor Agonists; Injections, Intraperitoneal; Lorazepam; Male; Oxadiazoles; Papio; Pentobarbital; Photic Stimulation; Quinoxalines; Rats; Rats, Long-Evans | 1999 |
Modulation of the immunological activation of human basophils by carbon monoxide.
Topics: Basophils; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hemin; Histamine Release; Humans; Oxadiazoles; Oxyhemoglobins; Quinoxalines | 1999 |
NO releases bombesin-like immunoreactivity from enteric synaptosomes by cross-activation of protein kinase A.
Topics: Animals; Arginine; Bombesin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Intestine, Small; Male; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Purinones; Quinoxalines; Rats; Rats, Wistar; Synaptosomes | 1999 |
Nitric oxide and cyclic GMP induce vesicle release at Drosophila neuromuscular junction.
Topics: Animals; Cyclic GMP; Drosophila melanogaster; Guanylate Cyclase; Immunohistochemistry; Larva; Neuromuscular Junction; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Presynaptic Terminals; Quinoxalines; Synaptic Vesicles | 1999 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents | 1999 |
Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Potassium Channels; Purinones; Quinoxalines; Rats; Rats, Wistar | 1999 |
Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
Topics: Animals; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Dinoprostone; Dopamine; Hyperalgesia; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Isoquinolines; Male; Oxadiazoles; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Rolipram; Second Messenger Systems; Sulfonamides; Tumor Necrosis Factor-alpha | 1999 |
Failure of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes.
Topics: Animals; Aorta, Thoracic; Carbachol; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Guanylate Cyclase; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Solubility | 1999 |
The neuromuscular transmission fade (Wedensky inhibition) induced by L-arginine in neuromuscular preparations from rats.
Topics: Animals; Arginine; Diaphragm; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Molsidomine; Muscle Contraction; Muscle, Skeletal; Neuromuscular Junction; Nitroarginine; Oxadiazoles; Phrenic Nerve; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission | 1999 |
Effects of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and Nomega(6)-nitro-L-arginine methyl ester (NAME) on cyclic GMP levels during muscarinic activation of tracheal smooth muscle.
Topics: Animals; Carbachol; Cattle; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscarinic Agonists; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Receptors, Muscarinic; Trachea | 1999 |
The soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3,-a] quinoxalin-1-one is a nonselective heme protein inhibitor of nitric oxide synthase and other cytochrome P-450 enzymes involved in nitric oxide donor bioactivation.
Topics: Animals; Aorta; Biotransformation; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hemeproteins; Indazoles; Male; Microsomes, Liver; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 1999 |
Release of nitric oxide within the coeliac plexus is involved in the organization of a gastroduodenal inhibitory reflex in the rabbit.
Topics: Action Potentials; Animals; Arginine; Benzoates; Celiac Plexus; Cyclic GMP; Duodenum; Enzyme Inhibitors; Female; Gastrointestinal Motility; Imidazoles; Male; Muscle, Smooth; Nitric Oxide; Nitroarginine; Oxadiazoles; Quinoxalines; Rabbits; Reflex; Stomach | 1999 |
Nitric oxide inhibits whole-cell current in cystic fibrosis pancreatic epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Calcium Channel Blockers; Cell Line; Charybdotoxin; Cyclic AMP; Cyclic GMP; Cystic Fibrosis; Diltiazem; Enzyme Inhibitors; Epithelial Cells; Glutathione; Humans; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Pancreas; Patch-Clamp Techniques; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 1999 |
Characterisation of nitrergic transmission in the isolated anococcygeus muscle of the female mouse.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Catechols; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Estrus; Female; Guanylate Cyclase; In Vitro Techniques; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Synaptic Transmission; Vasoactive Intestinal Peptide; Vasodilator Agents | 1999 |
Contribution of nitric oxide to the presynaptic inhibition by endothelin ETB receptor of the canine stellate ganglionic transmission.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Animals; Antihypertensive Agents; Dogs; Endothelin Receptor Antagonists; Enzyme Inhibitors; Female; In Vitro Techniques; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Stellate Ganglion; Sulfonamides; Synapses; Synaptic Transmission | 1999 |
Evidence that nitric oxide acts as an inhibitory neurotransmitter supplying taenia from the guinea-pig caecum.
Topics: Animals; Cecum; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Muscle Relaxation; Neurotransmitter Agents; Nicotinic Agonists; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Tetrodotoxin; Vasodilator Agents | 1999 |
Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Animals; Cell Line; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydroxycholesterols; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; PC12 Cells; Quinoxalines; Rats | 1999 |
Neuroprotective effects of DETA-NONOate, a nitric oxide donor, on hydrogen peroxide-induced neurotoxicity in cortical neurones.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Thionucleotides | 1999 |
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells.
Topics: Caffeine; Calcium; Cell Survival; Cyclic GMP; Guanylate Cyclase; Humans; Kinetics; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; tert-Butylhydroperoxide; Tumor Cells, Cultured | 1999 |
Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock.
Topics: Animals; Aorta; Cell Respiration; Cells, Cultured; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Interferon-gamma; Lipopolysaccharides; Male; Mice; Mitochondria; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide; Nitrites; Oxadiazoles; Oxidants; Quinoxalines; Rats; Rats, Wistar; Shock, Septic; Survival Analysis; Vasodilation | 1999 |
Atropine and ODQ antagonize tetanic fade induced by L-arginine in cats.
Topics: Animals; Arginine; Cats; Enzyme Inhibitors; Female; Guanylate Cyclase; Male; Muscle, Skeletal; Neural Conduction; Nitric Oxide; Oxadiazoles; Quinoxalines; Receptors, Muscarinic | 1999 |
Effects of L-arginine on the afferent resting activity in the cephalopod statocyst.
Topics: Action Potentials; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cystamine; DDT; Decapodiformes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Hair Cells, Vestibular; Imines; Immunosuppressive Agents; Male; Methylene Blue; Mollusca; NADP; NG-Nitroarginine Methyl Ester; Niacin; Nitric Oxide; Nitroarginine; Oxadiazoles; Postural Balance; Quinoxalines; Sodium Chloride | 1999 |
Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Heart; Milrinone; Oxadiazoles; Oxygen Consumption; Purinones; Quinoxalines | 1999 |
Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Male; Microdialysis; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Synaptic Transmission | 1999 |
Pharmacological manipulation of central nitric oxide/guanylate cyclase activity alters Fos expression by rat hypothalamic vasopressinergic neurons during acute glucose deprivation.
Topics: Animals; Deoxyglucose; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Hypothalamus; Immunoenzyme Techniques; Male; Molsidomine; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Proto-Oncogene Proteins c-fos; Quinoxalines; Rats; Rats, Sprague-Dawley; Transcription Factor AP-1; Vasopressins | 1999 |
Androgen-independent growth is induced by neuropeptides in human prostate cancer cell lines.
Topics: Androgens; Cell Division; Cyclic AMP; Dideoxyadenosine; Enzyme Inhibitors; Gastrin-Releasing Peptide; Humans; Male; Neuropeptides; Oxadiazoles; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Thymidine; Tumor Cells, Cultured | 2000 |
Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function | 1999 |
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
Topics: Adenosine; Alkaloids; Amides; Animals; Basilar Artery; Carbazoles; Cerebrovascular Circulation; Cyclic GMP; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; Hydroxyeicosatetraenoic Acids; Indoles; Male; Microcirculation; Middle Cerebral Artery; Mixed Function Oxygenases; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfones; Vasodilation; Vasodilator Agents | 1999 |
5-hydroxytryptamine- and U46619-mediated vasoconstriction in bovine pulmonary conventional and supernumerary arteries: effect of endogenous nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Lung; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Serotonin; Serotonin Antagonists; Urea; Vasoconstrictor Agents | 2000 |
NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO.
Topics: Animals; Cattle; Colforsin; Cyclic GMP; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Ferricyanides; Flavoproteins; Glutathione; Guanylate Cyclase; Heme; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADP; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Penicillamine; Pentose Phosphate Pathway; Pulmonary Artery; Quinoxalines; Reactive Oxygen Species; Sulfhydryl Compounds | 1999 |
Inhaled NO reaches distal vasculatures to inhibit endothelium- but not leukocyte-dependent cell adhesion.
Topics: Administration, Inhalation; Animals; Capillary Permeability; Cats; Cell Adhesion; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Hydrogen Peroxide; Leukocytes; Leukotriene B4; Lung; Microscopy, Video; Nitric Oxide; Oxadiazoles; Oxidants; Oxidative Stress; P-Selectin; Platelet Activating Factor; Quinoxalines | 1999 |
Nitric oxide is the predominant mediator of cerebellar hyperemia during somatosensory activation in rats.
Topics: Animals; Blood Pressure; Brain Stem; Carbon Dioxide; Cerebellar Cortex; Cerebellum; Cerebrovascular Circulation; Electric Stimulation; Enzyme Inhibitors; Glucose; Hyperemia; Indazoles; Laser-Doppler Flowmetry; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Somatosensory Cortex; Tetrodotoxin | 1999 |
cGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Coronary Vessels; Cyclic GMP; Down-Regulation; Endothelium, Vascular; Feedback; Guanylate Cyclase; Hemoglobins; Humans; Isosorbide Dinitrate; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilator Agents | 1999 |
Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Norepinephrine; Oxadiazoles; Potassium; Quinoxalines; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
In vitro, nitric oxide (NO) stimulates LH secretion and partially prevents the inhibitory effect of dopamine on PRL release.
Topics: Aminoquinolines; Animals; Cells, Cultured; Cyclic GMP; Dopamine; Enzyme Inhibitors; Guanylate Cyclase; Luteinizing Hormone; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Pituitary Gland, Anterior; Prolactin; Quinoxalines; Rats; Rats, Wistar | 1999 |
Nitric oxide causes a cGMP-independent intracellular calcium rise in porcine endothelial cells-a paradox?
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Hydrazines; Imidazoles; Intracellular Fluid; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Penicillamine; Quinoxalines; Spectrophotometry, Ultraviolet; Swine; Triazenes | 2000 |
Differential sensitivity among nitric oxide donors toward ODQ-mediated inhibition of vascular relaxation.
Topics: Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Drug Interactions; Guanylate Cyclase; Male; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2000 |
Insulin inhibits migration of vascular smooth muscle cells with inducible nitric oxide synthase.
Topics: Animals; Cell Movement; Cells, Cultured; Cyclic GMP; Dogs; Enzyme Inhibitors; Female; Femoral Artery; Guanylate Cyclase; Hypoglycemic Agents; Insulin; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines | 2000 |
An integrated model for determining causes of poor oral drug absorption.
Topics: Administration, Oral; Algorithms; Anti-Anxiety Agents; Antifungal Agents; Cardiotonic Agents; Computer Simulation; Digoxin; Gastric Emptying; Griseofulvin; Intestinal Absorption; Models, Theoretical; Oxadiazoles; Particle Size; Permeability; Pharmacokinetics; Predictive Value of Tests; Quinoxalines; Solubility | 1999 |
Characterization of the off response to electrical field stimulation in gallbladder smooth muscle.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gallbladder; Male; Nitric Oxide; Nitroarginine; Opossums; Oxadiazoles; Quinoxalines | 2000 |
Calmodulin-dependent activation of p38 and p42/44 mitogen-activated protein kinases contributes to c-fos expression by calcium in PC12 cells: modulation by nitric oxide.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Neoplastic; Genes, fos; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Potassium Chloride; Proto-Oncogene Proteins c-fos; Pyridines; Quinoxalines; Rats; Sulfonamides | 2000 |
Pharmacological evidence for both neuronal and smooth muscular PAC1 receptors and a VIP-specific receptor in rat colon.
Topics: Animals; Apamin; Colon; Female; Indazoles; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Tetrodotoxin; Vasoactive Intestinal Peptide | 1999 |
Effects of superoxide anion generators and thiol modulators on nitrergic transmission and relaxation to exogenous nitric oxide in the sheep urethra.
Topics: Animals; Ascorbate Oxidase; Benzoates; Ditiocarb; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Sheep; Sulfhydryl Compounds; Superoxide Dismutase; Superoxides; Synaptic Transmission; Urethra | 2000 |
Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Animals; Arteries; Cytochrome P-450 Enzyme System; Endothelium, Vascular; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Oxyhemoglobins; Penicillamine; Potassium; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Skin; Vasoconstrictor Agents | 2000 |
Evidence against potassium as an endothelium-derived hyperpolarizing factor in rat mesenteric small arteries.
Topics: Acetylcholine; Animals; Barium Compounds; Chlorides; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Indomethacin; Isometric Contraction; Male; Mesenteric Arteries; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2000 |
Spontaneous photo-relaxation of urethral smooth muscle from sheep, pig and rat and its relationship with nitrergic neurotransmission.
Topics: Adenine; Animals; Citrulline; Cold Temperature; Culture Techniques; Electric Stimulation; Enzyme Inhibitors; Female; Light; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Oxyhemoglobins; Phosphodiesterase Inhibitors; Photic Stimulation; Potassium; Purinones; Quinoxalines; Rats; Rats, Wistar; Sheep; Superoxides; Swine; Synaptic Transmission; Tetrodotoxin; Thiourea; Time Factors; Urethra | 2000 |
Suppression of acute and chronic opioid withdrawal by a selective soluble guanylyl cyclase inhibitor.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acids; Guanylate Cyclase; Locus Coeruleus; Male; Morphine; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2000 |
Endogenous production of nitric oxide and effects of nitric oxide and superoxide on melanotrope functioning in the pituitary pars intermedia of Xenopus laevis.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Guanylate Cyclase; Immunohistochemistry; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxadiazoles; Pituitary Gland; Quinoxalines; Superoxides; Xenopus laevis | 2000 |
Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Caffeine; Calcium Channel Blockers; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Ryanodine | 2000 |
Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Anti-Infective Agents; Benzophenanthridines; Cells, Cultured; Cyclic GMP; Dexamethasone; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Glucocorticoids; Glyburide; Heart Ventricles; Hypoglycemic Agents; Ischemic Preconditioning; Muscle Fibers, Skeletal; Myocardial Ischemia; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Oxadiazoles; Penicillamine; Phenanthridines; Potassium Channels; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley | 2000 |
Mediators of alkalosis-induced relaxation of piglet pulmonary veins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Alkalosis; Animals; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Nitric Oxide; Nitroarginine; Oxadiazoles; Peptides; Potassium Channels; Pulmonary Veins; Quinoxalines; Swine; Vasoconstrictor Agents; Vasodilation | 2000 |
Sodium nitroprusside augments human lung fibroblast collagen gel contraction independently of NO-cGMP pathway.
Topics: Animals; Cell Line; Collagen; Cyclic GMP; Dinoprostone; Enzyme Inhibitors; Fetus; Fibroblasts; Fibronectins; Gels; Humans; Lung; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Penicillamine; Platelet Aggregation Inhibitors; Quinoxalines; Rats; Thionucleotides; Vasodilator Agents | 2000 |
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Meloxicam; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Thiazines; Thiazoles | 2000 |
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
Topics: Antigens, CD; Apoptosis; Caspase 8; Caspase 9; Caspases; Ceramides; Cyclic GMP; Enzyme Inhibitors; Humans; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Proteins; Quinoxalines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; S-Nitroso-N-Acetylpenicillamine; Second Messenger Systems; Signal Transduction; Sphingosine; TNF Receptor-Associated Factor 1; Tumor Necrosis Factor-alpha; U937 Cells | 2000 |
Nitric oxide inhibits inducible nitric oxide synthase mRNA expression in RAW 264.7 macrophages.
Topics: Animals; Cell Line; Cell Survival; Enzyme Inhibitors; Indicators and Reagents; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Nitroprusside; Oxadiazoles; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Benzodifuroxan as an NO-dependent activator of soluble guanylate cyclase and a novel highly effective inhibitor of platelet aggregation.
Topics: Antihypertensive Agents; Blood Platelets; Cyclic GMP; Cyclic N-Oxides; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Guanylate Cyclase; Humans; Inhibitory Concentration 50; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Sulfhydryl Compounds | 2000 |
Endothelium-dependent sensory non-adrenergic non-cholinergic vasodilatation in rat thoracic aorta: involvement of ATP and a role for NO.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Evans Blue; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Purinergic P1 Receptor Antagonists; Purinergic P2 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin; Tetrodotoxin; Theophylline; Triazines; Vasodilation | 2000 |
Inhibition of the glutamate-induced K(+) current in identified Onchidium neurons by nitric oxide donors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Cyclic GMP; Enzyme Inhibitors; Ganglia, Invertebrate; Glutamic Acid; Hydrazines; Mollusca; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Potassium Channels; Quinoxalines; Vasodilator Agents | 2000 |
Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
Topics: Anal Canal; Animals; Autonomic Nervous System; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Sheep | 2000 |
Endogenous nitric oxide decreases hippocampal levels of serotonin and dopamine in vivo.
Topics: Animals; Arginine; Dopamine; Enzyme Inhibitors; Extracellular Space; Hippocampus; Indazoles; Male; Methylene Blue; Microdialysis; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin | 2000 |
Effect of 5-HT(1B) receptor ligands on self-administration of ethanol in an operant procedure in rats.
Topics: Alcohol Drinking; Animals; Conditioning, Operant; Ethanol; Indoles; Male; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Self Administration | 2000 |
Kinetic characterization of the nitric oxide toxicity for PC12 cells: effect of half-life time of NO release.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Survival; Cyclic GMP; Cysteine; Dibutyryl Cyclic GMP; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Glutathione; Half-Life; Kinetics; Nitric Oxide; Nitro Compounds; Oxadiazoles; PC12 Cells; Quinoxalines; Rats; Time Factors | 2000 |
Interplay between nitric oxide and vasoactive intestinal polypeptide in the pig gastric fundus smooth muscle.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Amidines; Animals; Arginine; Benzylamines; Carbazoles; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Indoles; Isoquinolines; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroarginine; Oxadiazoles; Protein Kinase Inhibitors; Pyrroles; Quinoxalines; Sulfonamides; Swine; Thionucleotides; Vasoactive Intestinal Peptide | 2000 |
NO/cGMP pathway activation and membrane potential depolarization in pig ciliary epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Ciliary Body; Cyclic GMP; Guanylate Cyclase; Ion Channels; Membrane Potentials; Microelectrodes; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pigment Epithelium of Eye; Quinoxalines; Swine; Thionucleotides | 2000 |
Role of endothelium/nitric oxide in atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isoproterenol; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Norepinephrine; Oxadiazoles; Phenoxyacetates; Phenoxypropanolamines; Phenylacetates; Pindolol; Propanolamines; Propranolol; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Vasodilation | 2000 |
[Membrane potential depolarization in the porcine ciliary epithelium evoked by nitric oxide].
Topics: Animals; Aqueous Humor; Cell Membrane; Ciliary Body; Enzyme Inhibitors; Epithelial Cells; Guanosine Monophosphate; Guanylate Cyclase; In Vitro Techniques; Ion Channels; Membrane Potentials; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Swine; Vasodilator Agents | 2000 |
Reduction in the level of cardiac cyclic GMP worsens contractile delay in myocardial stunning.
Topics: Animals; Coronary Circulation; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Myocardial Stunning; Myocardium; Nitric Oxide; Oxadiazoles; Oxygen Consumption; Quinoxalines; Rabbits | 2000 |
L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway.
Topics: Analgesics; Animals; Arginine; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Phthalazines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2000 |
1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) inhibits cyclic GMP-PKG pathway-independent nonadrenergic, noncholinergic relaxation in longitudinal muscle of the rectum of Wistar-ST rats.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Neuropeptides; Nitroarginine; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Rats; Rats, Wistar; Rectum; Vasoactive Intestinal Peptide | 2000 |
Intravesical oxyhemoglobin initiates bladder overactivity in conscious, normal rats.
Topics: Administration, Intravesical; Amides; Animals; Arginine; Benzophenones; Enzyme Inhibitors; Female; Free Radical Scavengers; Guanylate Cyclase; Nitric Oxide; Oxadiazoles; Oxyhemoglobins; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urination; Urothelium | 2000 |
Decreasing cyclic GMP exerts similar positive functional effects on cardiac myocytes regardless of initial level.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heart; In Vitro Techniques; Myocardium; Oxadiazoles; Oxygen Consumption; Purinones; Quinoxalines; Rabbits | 2000 |
Sildenafil relaxes rabbit clitoral corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Clitoris; Electric Stimulation; Female; Guanylate Cyclase; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones; Synaptic Transmission; Tetrodotoxin | 2000 |
Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries.
Topics: Animals; Cerebral Arteries; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2000 |
Mechanisms of nitric oxide-independent relaxations induced by carbachol and acetylcholine in rat isolated renal arteries.
Topics: Acetylcholine; Animals; Carbachol; Charybdotoxin; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indomethacin; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ouabain; Oxadiazoles; Peptides; Phenylephrine; Potassium; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Artery; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2000 |
Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion.
Topics: Animals; Benzoates; Cyclic GMP; Dizocilpine Maleate; Dose-Response Relationship, Drug; Endotoxins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Glycine; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pentagastrin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Solubility; Stomach; Vagotomy | 2000 |
The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent.
Topics: Alkaline Phosphatase; Animals; Apoptosis; Cell Division; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Osteoblasts; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2000 |
Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells.
Topics: Alkaloids; Animals; Arginine; Carbazoles; Cells, Cultured; Cilia; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Glutathione; Indoles; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; omega-N-Methylarginine; Oxadiazoles; Purinones; Quinoxalines; Rats; S-Nitrosoglutathione; Signal Transduction; Trachea | 2000 |
Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices: involvement of 5-HT(2C) and 5-HT(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylamines; Female; Humans; In Vitro Techniques; Indoles; Male; Middle Aged; N-Methylaspartate; Neocortex; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Trazodone | 2000 |
Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Arachidonic Acids; Biological Factors; Cerebral Arteries; Charybdotoxin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Ouabain; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Vasodilation; Vasodilator Agents | 2000 |
Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP).
Topics: Acetylcholine; Animals; Capsaicin; Guinea Pigs; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Oxadiazoles; Penicillamine; Quinoxalines; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Trachea | 2000 |
Role of cGMP as a mediator of nerve-induced motor functions of the opossum esophagus.
Topics: Animals; Atropine; Cyclic GMP; Enteric Nervous System; Enzyme Inhibitors; Esophagogastric Junction; Female; Gastrointestinal Motility; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Smooth; Nitric Oxide; Opossums; Oxadiazoles; Parasympatholytics; Quinoxalines; Vasoactive Intestinal Peptide | 2000 |
Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryl trinitrate-tolerant rat femoral arteries.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Femoral Artery; Glucosamine; Glutathione; Hemoglobins; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Penicillamine; Perfusion; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2000 |
Inhibition of soluble guanylate cyclase by ODQ.
Topics: Animals; Baculoviridae; Electron Spin Resonance Spectroscopy; Enzyme Activation; Enzyme Inhibitors; Ferric Compounds; Ferrous Compounds; Genetic Vectors; Guanylate Cyclase; Heme; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Peptide Fragments; Quinoxalines; Rats; Solubility; Spectrophotometry; Spectrum Analysis, Raman; Spodoptera | 2000 |
Nitric oxide provokes tumor necrosis factor-alpha expression in adult feline myocardium through a cGMP-dependent pathway.
Topics: Animals; Benzoates; Cats; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA-Binding Proteins; Electrophoresis; I-kappa B Proteins; Imidazoles; In Vitro Techniques; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Phosphorylation; Protein Kinases; Quinoxalines; RNA, Messenger; Thionucleotides; Tumor Necrosis Factor-alpha | 2000 |
Abnormal activation of K(+) channels in aortic smooth muscle of rats with endotoxic shock: electrophysiological and functional evidence.
Topics: Animals; Aorta; Apamin; Benzimidazoles; Charybdotoxin; Drug Interactions; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Hypotension; Lipopolysaccharides; Male; Membrane Potentials; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2000 |
Endotoxin causes up-regulation of endothelin receptors in cultured hepatic stellate cells via nitric oxide-dependent and -independent mechanisms.
Topics: Animals; Cell Line, Transformed; Cells, Cultured; Endotoxins; Lipopolysaccharides; Liver; Male; Nitric Oxide; Nitrites; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Time Factors; Up-Regulation | 2000 |
Inhibitory effect of nitric oxide on the induction of cytochrome P450 3A4 mRNA by 1,25-dihydroxyvitamin D3 in Caco-2 cells.
Topics: Caco-2 Cells; Calcitriol; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Stability; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Mixed Function Oxygenases; Nitric Oxide; Oxadiazoles; Quinoxalines; RNA, Messenger | 2000 |
Increase in peripheral blood flow due to extraocular direct irradiation of visible light in rats.
Topics: Animals; Blood Flow Velocity; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eye Protective Devices; Injections, Intraperitoneal; Laser-Doppler Flowmetry; Lasers; Light; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Regional Blood Flow; Skin; Tail; Vasodilator Agents | 2000 |
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase | 2000 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nicorandil; Nitroarginine; Oxadiazoles; Potassium Channels; Pregnancy; Quinoxalines; Serotonin; Temperature; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria.
Topics: Age Factors; Animals; Aortic Bodies; Arginine; Blotting, Western; Carbachol; Cardiotonic Agents; Cyclic GMP; Digestive System; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Atria; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Ornithine; Oxadiazoles; Prosencephalon; Quinoxalines; Receptors, Atrial Natriuretic Factor; Time Factors | 2000 |
Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery.
Topics: Calcium Channels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxygen; Potassium; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Receptors, Atrial Natriuretic Factor; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
Nitric oxide and cGMP influence axonogenesis of antennal pioneer neurons.
Topics: Animals; Axonal Transport; Axons; Cyclic GMP; Dihydrolipoamide Dehydrogenase; Embryo, Nonmammalian; Enzyme Inhibitors; Grasshoppers; Guanylate Cyclase; Horseradish Peroxidase; Indazoles; Morphogenesis; Nervous System; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction | 2000 |
Cyclic GMP-independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor.
Topics: Animals; Cyclic GMP; Male; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; Spermine; Vasodilation | 2000 |
gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Carbachol; Cell Division; Cell Line; Cell Survival; Cholinergic Agonists; Colforsin; Cyclic GMP; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Models, Chemical; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Phorbol Esters; Protein Kinase C; Quinoxalines; Rats; Spermine; Type C Phospholipases; Vitamin E | 2000 |
Inhibitory effect of cyclic guanosine 3',5'-monophosphate (cGMP) on the afferent resting activity in the cephalopod statocyst.
Topics: Afferent Pathways; Animals; Cyclic GMP; Cystamine; Decapodiformes; Dibutyryl Cyclic GMP; Dideoxyadenosine; Enzyme Inhibitors; Imines; Methylene Blue; Mollusca; NG-Nitroarginine Methyl Ester; Niacin; Nitroarginine; Oxadiazoles; Quinoxalines; Sense Organs | 2000 |
Inhibition of K(Ca) channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis.
Topics: Animals; Apamin; Charybdotoxin; Common Bile Duct; Endothelin-1; Enzyme Inhibitors; Gene Expression Regulation; Liver Cirrhosis, Biliary; Lung; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Potassium Chloride; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Transcription, Genetic; Vasoconstriction | 2000 |
Nitric oxide modulates intracellular translocation of pigment organelles in Xenopus laevis melanophores.
Topics: Alkaloids; Animals; Arginine; Biological Transport; Blotting, Western; Carbazoles; Cells, Cultured; Cyclic GMP; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Guanylate Cyclase; Indoles; Melanophores; Microscopy, Fluorescence; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Signal Transduction; Time Factors; Xenopus laevis | 2000 |
Carbachol inhibits Na(+)-K(+)-ATPase activity in choroid plexus via stimulation of the NO/cGMP pathway.
Topics: Adenosine Triphosphate; Animals; Carbachol; Cattle; Cholinergic Agonists; Choroid Plexus; Cyclic GMP; Enzyme Inhibitors; Hydrolysis; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Ouabain; Oxadiazoles; Phosphorylation; Quinoxalines; Sodium-Potassium-Exchanging ATPase; Solubility; Thionucleotides; Triazenes; Vasodilator Agents | 2000 |
Nitric oxide: a trigger for classic preconditioning?
Topics: Adenosine Monophosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Epinephrine; Guanylate Cyclase; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sympathomimetics; Vasodilator Agents | 2000 |
Novel S-nitrosothiols do not engender vascular tolerance and remain effective in glyceryltrinitrate-tolerant rat femoral arteries.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Femoral Artery; Glucosamine; Glutathione; Guanylate Cyclase; In Vitro Techniques; Male; Methemoglobin; Nitric Oxide Donors; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Penicillamine; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Vasoconstrictor Agents; Vasodilation | 2000 |
Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Cyclic GMP; Enzyme Inhibitors; Glucosamine; Glutathione; Humans; In Vitro Techniques; Kinetics; Models, Biological; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Nitroso Compounds; Oxadiazoles; Penicillamine; Platelet Aggregation; Platelet Aggregation Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; S-Nitrosoglutathione | 2000 |
NO-mediated MaxiK(Ca) channel activation produces relaxation of guinea pig aorta independently of voltage-dependent L-type Ca(2+) channels.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels, L-Type; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Nitroarginine; Norepinephrine; Oxadiazoles; Peptides; Piperidines; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Chloride; Quinoxalines; Vasodilation | 2000 |
Nitric oxide modulation of interleukin-1[beta]-evoked intracellular Ca2+ release in human astrocytoma U-373 MG cells and brain striatal slices.
Topics: Aminoquinolines; Animals; Arginine; Astrocytoma; Calcium; Corpus Striatum; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Heparin; Humans; Hydrazines; In Vitro Techniques; Interleukin-1; Intracellular Fluid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Spermine; Tumor Cells, Cultured | 2000 |
Nitric oxide attenuates H(2)O(2)-induced endothelial barrier dysfunction: mechanisms of protection.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Oxidants; Penicillamine; Phosphodiesterase Inhibitors; Pulmonary Artery; Quinoxalines; Swine; Thionucleotides | 2001 |
Pharmacological profile of T-1032, a novel specific phosphodiesterase type 5 inhibitor, in isolated rat aorta and rabbit corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitroprusside; Oxadiazoles; Papaverine; Penis; Phenylephrine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Pyridines; Quinoxalines; Rabbits; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tetrodotoxin; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to l-arginine.
Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Up-Regulation | 2001 |
Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms.
Topics: 3-O-Methylglucose; Animals; Arteries; Calcium; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Glucose; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Reference Values; Tail; Time Factors; Vasodilation; Vasodilator Agents | 2001 |
Whole brain spheroid cultures as a model to study the development of nitric oxide synthase-guanylate cyclase signal transduction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Atrial Natriuretic Factor; Brain; Cell Culture Techniques; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Pregnancy; Quinoxalines; Rats; Rats, Inbred Lew; Signal Transduction; Vasodilator Agents | 2000 |
Inhibitory effect of valves on endothelium-dependent relaxations to calcium ionophore in canine saphenous vein.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Calcium; Colforsin; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Indomethacin; Ionophores; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Potassium Chloride; Quinoxalines; Saphenous Vein; Vasoconstrictor Agents; Vasodilation | 2001 |
Modulation of neuronal nitric oxide release by soluble guanylyl cyclase in guinea pig colon.
Topics: Animals; Arginine; Colon; Cyclic GMP; Dimethyl Sulfoxide; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Immunohistochemistry; Male; Muscle, Smooth; Neurons; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2001 |
Discriminative stimulus effects of panadiplon (U-78875), a partial agonist at the benzodiazepine site, in pentobarbital-trained rhesus monkeys.
Topics: Animals; Anti-Anxiety Agents; Discrimination, Psychological; Dose-Response Relationship, Drug; GABA Modulators; Macaca mulatta; Male; Oxadiazoles; Pentobarbital; Quinoxalines; Reaction Time; Receptors, GABA-A; Triazolam | 2001 |
Modulation of nitrergic relaxant responses by peptides in the mouse gastric fundus.
Topics: Animals; Apamin; Carbachol; Cholinergic Agonists; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Neuropeptides; Neurotransmitter Agents; Nitroarginine; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Vasoactive Intestinal Peptide | 2001 |
Posttranscriptional regulation of human iNOS by the NO/cGMP pathway.
Topics: Cells, Cultured; Cyclic GMP; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Humans; Interleukin-1; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; RNA Stability; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
NO/cGMP signaling modulates regulation of Na+-K+-ATPase activity by angiotensin II in rat proximal tubules.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Calcium; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Intracellular Membranes; Kidney Tubules, Proximal; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Solubility | 2001 |
Matrix metalloproteinase 2 in tumor cell-induced platelet aggregation: regulation by nitric oxide.
Topics: Adenosine Diphosphate; Blood Platelets; Cell Communication; Enzyme Inhibitors; Epoprostenol; Fibrosarcoma; Gelatinases; Glutathione; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasms, Experimental; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Penicillamine; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione; Thromboxane A2; Tumor Cells, Cultured | 2001 |
Roles for nitric oxide and arachidonic acid in the induction of heterosynaptic cerebellar LTD.
Topics: Animals; Arachidonic Acid; Cerebellum; Enzyme Inhibitors; Indazoles; Male; Neuronal Plasticity; Nitric Oxide; Oxadiazoles; Phospholipases A; Phospholipases A2; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission | 2001 |
Carbon monoxide is the heme oxygenase product with a pyretic action: evidence for a cGMP signaling pathway.
Topics: Animals; Biliverdine; Body Temperature Regulation; Brain; Carbon Dioxide; Cerebral Ventricles; Deferoxamine; Deuteroporphyrins; Enzyme Inhibitors; Escherichia coli; Fever; Heme Oxygenase (Decyclizing); Injections, Intraventricular; Iron; Lipopolysaccharides; Male; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2001 |
Mechanisms that produce nitric oxide-mediated relaxation of cerebral arteries during atherosclerosis.
Topics: Animals; Basilar Artery; Cerebral Arteries; Cholesterol; Diet, Atherogenic; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Intracranial Arteriosclerosis; Macaca fascicularis; Male; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Papaverine; Quinoxalines; Vasoconstriction; Vasodilation; Vasodilator Agents | 2001 |
Effect of NO donors on protein phosphorylation in intact vascular and nonvascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myometrium; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Phosphoproteins; Phosphorylation; Quinoxalines; Rats; S-Nitroso-N-Acetylpenicillamine; Vas Deferens | 2001 |
Opposing actions of nitric oxide on synaptic inputs of identified interneurones in the central nervous system of the crayfish.
Topics: Animals; Arginine; Astacoidea; Cyclic GMP; Cyclic N-Oxides; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Free Radical Scavengers; Ganglia, Invertebrate; Imidazoles; In Vitro Techniques; Interneurons; Male; Mechanoreceptors; Nerve Net; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Synapses; Synaptic Transmission | 2001 |
Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats.
Topics: Acetylcholine; Animals; Barium; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Glycyrrhetinic Acid; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Ouabain; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Inbred WKY; Renal Artery; Vasodilation; Vasodilator Agents | 2001 |
Effect of peroxynitrite on motor function of the opossum esophagus.
Topics: Animals; Enzyme Inhibitors; Esophagitis; Esophagogastric Junction; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitrates; Opossums; Oxadiazoles; Oxidants; Oxyhemoglobins; Quinoxalines; Tyrosine | 2001 |
The dual effect of a nitric oxide donor in nociception.
Topics: Animals; Chronic Disease; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemoglobins; Injections, Spinal; Ligation; Male; Molsidomine; Nerve Compression Syndromes; Neuralgia; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Sciatic Nerve | 2001 |
Regulation of cardiac calcium current by NO and cGMP-modulating agents.
Topics: Adenine; Animals; Arginine; Biological Transport; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Cyclic GMP; Cyclic N-Oxides; Enzyme Inhibitors; Exonucleases; Free Radical Scavengers; Guinea Pigs; Imidazoles; In Vitro Techniques; Myocardium; Nitric Oxide; omega-N-Methylarginine; Orchiectomy; Oxadiazoles; Quinoxalines; Receptors, Muscarinic | 2001 |
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Brain; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoenzymes; Light; Male; Mammals; Mesocricetus; Motor Activity; Oxadiazoles; Photoperiod; Quinoxalines; Signal Transduction; Suprachiasmatic Nucleus | 2001 |
Effects of endothelin-1 and nitric oxide on proliferation of cultured guinea pig bronchial smooth muscle cells.
Topics: Animals; Bronchi; Cell Division; Cells, Cultured; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Male; Molsidomine; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Peptides, Cyclic; Quinoxalines | 2001 |
Nitric oxide modulates cardiac performance in the heart of Anguilla anguilla.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetylcholine; Anguilla; Animals; Arginine; Atropine; Detergents; Enzyme Inhibitors; Female; Free Radical Scavengers; Heart; Heart Rate; Hemodynamics; In Vitro Techniques; Male; Molsidomine; Muscarinic Antagonists; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Octoxynol; omega-N-Methylarginine; Ornithine; Oxadiazoles; Parasympatholytics; Pirenzepine; Quinoxalines; Superoxide Dismutase | 2001 |
Peroxynitrite leads to arteriolar smooth muscle cell membrane hyperpolarization and low vasoreactivity in severe shock.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Arginine; Arterioles; Charybdotoxin; Cyclic GMP; Drug Interactions; Female; Free Radical Scavengers; Glyburide; Guanidines; Ion Transport; Male; Membrane Potentials; Mesenteric Arteries; Microscopy, Confocal; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Penicillamine; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Vasodilator Agents | 2000 |
Mechanism of carbon monoxide-induced relaxation in the guinea pig ileal smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Carbon Monoxide; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Patch-Clamp Techniques; Potassium Chloride; Quinoxalines; Signal Transduction | 2001 |
Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation.
Topics: Acidosis; Animals; Aorta; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypoxia; In Vitro Techniques; Indicators and Reagents; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Regional Blood Flow; Sodium Nitrite; Vasodilation | 2001 |
Differential regulation of contractility and nitric oxide sensitivity in gravid and nongravid myometrium during late pregnancy in a marsupial.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Female; Gestational Age; Guanylate Cyclase; Kinetics; Marsupialia; Myometrium; Nitric Oxide; Oxadiazoles; Oxytocin; Pregnancy; Quinoxalines; Uterine Contraction | 2001 |
Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase.
Topics: Aging; Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Ferrets; Geniculate Bodies; Guanylate Cyclase; In Vitro Techniques; Indoles; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Presynaptic Terminals; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Synaptophysin | 2001 |
Signaling pathway of nitric oxide-induced acrosome reaction in human spermatozoa.
Topics: Acrosome Reaction; Aminoquinolines; Calcium; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Male; Naphthalenes; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Protein Kinase C; Quinoxalines; Signal Transduction; Sperm Capacitation; Spermatozoa | 2001 |
N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcysteine; Adenosine Diphosphate; Adult; Calcimycin; Cell Membrane Permeability; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Humans; Ionomycin; Male; omega-N-Methylarginine; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinones; Quinoxalines | 2001 |
Nitric oxide regulates actin reorganization through cGMP and Ca(2+)/calmodulin in RAW 264.7 cells.
Topics: Actins; Animals; Bucladesine; Calcium; Calmodulin; Cell Line; Cyclic GMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Flow Cytometry; Interferon-gamma; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Sulfonamides | 2001 |
Flow induces dilatation in the femoral artery of uraemic rats but constriction in control rats.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Electrolytes; Enzyme Inhibitors; Femoral Artery; Hemoglobins; Male; Muscle Tonus; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Reference Values; Regional Blood Flow; Uremia; Vasodilation | 2001 |
The influence of nitric oxide donors on the responses to nitrergic nerve stimulation in the mouse duodenum.
Topics: Animals; Dose-Response Relationship, Drug; Duodenum; Electric Stimulation; Enzyme Inhibitors; Ethylmaleimide; Female; Hemoglobins; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Quinoxalines; Thiazines | 2001 |
The cerebrovascular response to elevated potassium--role of nitric oxide in the in vitro model of isolated rat middle cerebral arteries.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Cyclic GMP; Enzyme Inhibitors; Extracellular Space; Male; Middle Cerebral Artery; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Organ Culture Techniques; Oxadiazoles; Penicillamine; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilation | 2001 |
Regulation of ERK phosphorylation in differentiated arterial muscle of rabbits.
Topics: Animals; Arteries; Enzyme Activation; Enzyme Inhibitors; Female; Flavonoids; Histological Techniques; In Vitro Techniques; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Osmolar Concentration; Oxadiazoles; Phenylephrine; Phosphorylation; Quinoxalines; Rabbits; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2001 |
Neural regulation of in vitro giant contractions in the rat colon.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Antineoplastic Agents; Benzazepines; Calcium Channel Agonists; Calcium Channel Blockers; Colon; Cyclic GMP; Dopamine Antagonists; Enzyme Inhibitors; Hexamethonium; Imines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Nitric Oxide; Nitroarginine; omega-Conotoxins; Oxadiazoles; Peristalsis; Quinoxalines; Rats; Rats, Sprague-Dawley; Suramin; Tetrodotoxin | 2001 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
Relaxation to authentic nitric oxide and SIN-1 in rat isolated mesenteric arteries: variable role for smooth muscle hyperpolarization.
Topics: 4-Aminopyridine; Animals; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Molsidomine; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Peptides; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 2001 |
Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Capsaicin; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Spinal; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Nimodipine; Nitric Oxide; Nitric Oxide Donors; omega-Conotoxin GVIA; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Urinary Bladder | 2001 |
Control of survival of proliferating L1210 cells by soluble guanylate cyclase and p44/42 mitogen-activated protein kinase modulators.
Topics: Animals; Apoptosis; Caspases; Cell Division; Cell Survival; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Leukemia L1210; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxadiazoles; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinoxalines; Signal Transduction; Tumor Cells, Cultured | 2001 |
Prostaglandins and nitric oxide mediate superoxide-induced myocardial contractile dysfunction in isolated rat hearts.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartate Aminotransferases; Colforsin; Enzyme Inhibitors; Heart; Myocardial Contraction; Myocardium; Nitrates; Nitric Acid; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Prostaglandins; Quinoxalines; Rats; Superoxides; Thromboxane A2; Vasodilator Agents | 2001 |
Lipid hydroperoxide and cGMP are not involved in nitric oxide inhibition of steroidogenesis in bovine granulosa cells.
Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Granulosa Cells; Guanylate Cyclase; Lipid Peroxidation; Lipid Peroxides; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Steroids | 2000 |
In vivo pharmacology of BIIR 561 CL, a novel combined antagonist of AMPA receptors and voltage-dependent Na(+) channels.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Death; Dose-Response Relationship, Drug; Electric Stimulation; Female; Lethal Dose 50; Male; Mexiletine; Mice; Neuroprotective Agents; Oxadiazoles; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, AMPA; Sodium Channel Blockers | 2001 |
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Pyrilamine; Quinoxalines; Rats; Rats, Wistar; Rimonabant; Signal Transduction; Stereoisomerism; Theophylline; Vasodilation | 2001 |
Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Acetylcholine; Adenine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Male; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Purinones; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2001 |
The relaxation induced by S-nitroso-glutathione and S-nitroso-N-acetylcysteine in rat aorta is not related to nitric oxide production.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Ryanodine; S-Nitrosoglutathione; Thapsigargin; Vasoconstrictor Agents; Vasodilation | 2001 |
Phentolamine mesylate relaxes rabbit corpus cavernosum by a nonadrenergic, noncholinergic mechanism.
Topics: Adrenergic alpha-Antagonists; Animals; Cyclic GMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Penis; Phentolamine; Quinoxalines; Rabbits; Tetrodotoxin | 2001 |
Inhibition of DNA synthesis in cultured hepatocytes by endotoxin-conditioned medium of activated stellate cells is transforming growth factor-beta and nitric oxide-independent.
Topics: Animals; Antibodies, Monoclonal; Cells, Cultured; Culture Media, Conditioned; DNA; Dose-Response Relationship, Drug; Endotoxins; Gene Expression Regulation, Enzymologic; Hepatocytes; Interleukin-1; Interleukin-6; Lipopolysaccharides; Liver; Male; Neutralization Tests; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor alpha; Transforming Growth Factor beta | 2001 |
Nitric oxide directly activates GABA(A) receptor function through a cGMP/protein kinase-independent pathway in frog pituitary melanotrophs.
Topics: Aminoquinolines; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dithionitrobenzoic Acid; Electric Conductivity; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hydrazines; Ion Channel Gating; Male; Melanocytes; Membrane Potentials; Mercaptoethanol; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Oxidation-Reduction; Patch-Clamp Techniques; Pituitary Gland; Quinoxalines; Rana ridibunda; Receptors, GABA-A; Sulfhydryl Reagents | 2001 |
Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Penis; Phenylephrine; Potassium Channels; Quinoxalines; Rabbits; Vasodilator Agents | 2001 |
The selective guanylate cyclase inhibitor ODQ reduces multiple organ injury in rodent models of Gram-positive and Gram-negative shock.
Topics: Animals; Cells, Cultured; Enzyme Inhibitors; Escherichia coli Infections; Guanylate Cyclase; Hemodynamics; Hydrogen Peroxide; Kidney; Liver; Lung; Male; Multiple Organ Failure; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Shock, Septic; Staphylococcal Infections | 2001 |
Actions of NO donors and endogenous nitrergic transmitter on the longitudinal muscle of rat ileum in vitro: mechanisms involved.
Topics: Animals; Apamin; Atropine; Calcium Channels; Charybdotoxin; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Ileum; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetrodotoxin | 2001 |
Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat.
Topics: Acetylcholine; Adamantane; Adrenomedullin; Amyloid; Animals; Arginine; Calcitonin Gene-Related Peptide; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; In Vitro Techniques; Islet Amyloid Polypeptide; Mesenteric Arteries; Morpholines; Nitric Oxide Synthase; Oxadiazoles; Peptide Fragments; Peptides; Perfusion; Potassium Channel Blockers; Quinoxalines; Rats; Receptors, Calcitonin Gene-Related Peptide; Receptors, Islet Amyloid Polypeptide; Receptors, Peptide; Vascular Resistance; Vasodilator Agents | 2001 |
Characterization of vagal input to the rat esophageal muscle.
Topics: Animals; Atropine; Enteric Nervous System; Enzyme Inhibitors; Esophagus; Galanin; Gastrointestinal Agents; Hexamethonium; Hydrazines; Male; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Muscle, Smooth; Nicotinic Antagonists; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Oxadiazoles; Parasympatholytics; Quinoxalines; Rats; Rats, Wistar; Serotonin; Tetrodotoxin; Tubocurarine; Vagus Nerve; Vasoactive Intestinal Peptide | 2001 |
The AMPA receptor/Na(+) channel blocker BIIR 561 CL is protective in a model of global cerebral ischaemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; Male; Neuroprotective Agents; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sodium Channel Blockers; Survival Rate | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxytocin; Penicillamine; Peptides; Pregnancy; Quinoxalines; S-Nitrosothiols; Scorpion Venoms; Time Factors; Uterus | 2001 |
Reduced sarco/endoplasmic reticulum Ca(2+) uptake activity can account for the reduced response to NO, but not sodium nitroprusside, in hypercholesterolemic rabbit aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium; Calcium-Transporting ATPases; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethylenediamines; Free Radical Scavengers; Hypercholesterolemia; In Vitro Techniques; Indoles; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Organometallic Compounds; Oxadiazoles; Quinoxalines; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Superoxide Dismutase; Thapsigargin; Vasodilation | 2001 |
Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac.
Topics: Adenosine Triphosphate; Analgesics; Animals; Behavior, Animal; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glyburide; Guanylate Cyclase; Ketorolac; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Penicillamine; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2001 |
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbachol; Carbazoles; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Isoquinolines; Milrinone; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-Conotoxin GVIA; Oxadiazoles; Phosphorylation; Presynaptic Terminals; Quinoxalines; Sinoatrial Node; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve | 2001 |
cGMP-mediated inhibition of cardiac L-type Ca(2+) current by a monoclonal antibody against the M(2) ACh receptor.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Antibodies, Monoclonal; Autoantibodies; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanosine; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Fibers, Skeletal; Myocardium; Oxadiazoles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Cyanides; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanylate Cyclase; Hippocampus; Hydrazines; Long-Term Potentiation; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2001 |
Requirement of protein tyrosine phosphatase SHP2 for NO-stimulated vascular smooth muscle cell motility.
Topics: Animals; Aorta; Cell Movement; Cyclic GMP; Enzyme Inhibitors; Helminth Proteins; Male; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Oligonucleotides, Antisense; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 2001 |
Mechanism mediating nitric oxide-induced inhibition in human jejunal longitudinal smooth muscle.
Topics: Electric Stimulation; Enteric Nervous System; Enzyme Inhibitors; Gastrointestinal Motility; Guanylate Cyclase; Humans; In Vitro Techniques; Jejunum; Muscle, Smooth; Neural Inhibition; Nitric Oxide; Oxadiazoles; Quinoxalines | 2001 |
A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Aorta; Aorta, Thoracic; Blood Pressure; Cells, Cultured; Cromakalim; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Heart Rate; In Vitro Techniques; Methylene Blue; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphoric Diester Hydrolases; Piperidines; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Solubility; Vasodilation; Vasodilator Agents; Xanthine; Xanthines | 2001 |
Renal interstitial cGMP mediates natriuresis by direct tubule mechanism.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Anesthesia; Animals; Arginine; Bacterial Toxins; Benzimidazoles; Consciousness; Cyclic AMP; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Female; Glomerular Filtration Rate; Kidney; Kidney Tubules; Microscopy, Fluorescence; Natriuresis; Nephrectomy; NG-Nitroarginine Methyl Ester; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium; Thionucleotides; Xanthenes | 2001 |
High-salt diet enhances vascular reactivity in pregnant rats with normal and reduced uterine perfusion pressure.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Nitroprusside; Oxadiazoles; Phenylephrine; Pregnancy; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Uterus; Vasoconstrictor Agents; Vasodilator Agents | 2001 |
Long-term inhibition of nitric oxide synthase potentiates effects of anandamide in the rat mesenteric bed.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Oxadiazoles; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Time Factors; Vasoconstriction; Vasoconstrictor Agents | 2001 |
The vasorelaxation of cerebral arteries by carbon monoxide.
Topics: Animals; Carbon Monoxide; Cerebral Arteries; Dinoprost; Dogs; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Tetraethylammonium; Vasodilation | 2001 |
Mechanism of a nitric oxide donor NOR 1-induced relaxation in longitudinal muscle of rat proximal colon.
Topics: Animals; Calcium; Carbachol; Colon; Culture Techniques; Cyclic GMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Male; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Thapsigargin; Thionucleotides | 2001 |
Nitric oxide contracts longitudinal smooth muscle of opossum oesophagus via excitation-contraction coupling.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Cyclic GMP; Enzyme Inhibitors; Esophagus; Female; In Vitro Techniques; Isometric Contraction; Male; Microelectrodes; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Opossums; Oxadiazoles; Quinoxalines; Signal Transduction; Tetrodotoxin; Triazenes | 2001 |
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Ion Channel Gating; Ion Transport; Ionomycin; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Posterior; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Signal Transduction; Sodium; Sodium Channels; Sulfonamides; Thionucleotides | 2001 |
The nNOS/cGMP signal transducing system is involved in the cardiovascular responses induced by activation of NMDA receptors in the rostral ventrolateral medulla of cats.
Topics: Animals; Blood Pressure; Bradycardia; Cats; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; Heart Rate; Hypertension; Indazoles; Male; Medulla Oblongata; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2001 |
Nitric oxide regulates human eosinophil adhesion mechanisms in vitro by changing integrin expression and activity on the eosinophil cell surface.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Separation; Cyclic GMP; Enzyme Inhibitors; Eosinophils; Fibronectins; Humans; Integrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines | 2001 |
Nitric oxide inhibition of cAMP synthesis in parotid acini: regulation of type 5/6 adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Isoproterenol; Mice; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Parotid Gland; Phosphoric Diester Hydrolases; Quinoxalines; Thapsigargin; Triazoles | 2001 |
NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes.
Topics: Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Guanylate Cyclase; Humans; Interleukin-6; Lipopolysaccharides; Monocytes; Nitric Oxide; Oxadiazoles; Quinoxalines; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha | 2001 |
Dominant role of an endothelium-derived hyperpolarizing factor (EDHF)-like vasodilator in the ciliary vascular bed of the bovine isolated perfused eye.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Barium; Biological Factors; Blood Vessels; Bradykinin; Cattle; Charybdotoxin; Ciliary Body; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Eye; Flurbiprofen; Glyburide; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Ouabain; Oxadiazoles; Perfusion; Potassium; Potassium Channel Blockers; Pressure; Quinoxalines; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Basal tonic release of nitric oxide coupled to cGMP production regulates the vascular reactivity of the mesenteric bed.
Topics: Acetylcholine; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Oxadiazoles; Oxidopamine; Phenylephrine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Saponins; Sildenafil Citrate; Solubility; Sulfones; Sympatholytics; Time Factors; Vascular Resistance; Vasodilation; Vasodilator Agents; Yohimbine | 2001 |
YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components.
Topics: Base Sequence; DNA Primers; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; Heme; Indazoles; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Solubility | 2001 |
Interleukin-1beta stimulates cyclic GMP efflux in brain astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Brain; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Interleukin-1; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Probenecid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Verapamil | 2001 |
Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbon Monoxide; Cyclic GMP; Dipyridamole; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hypertension, Pulmonary; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Pulmonary Circulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vascular Resistance; Vasodilation | 2001 |
Role of nitric oxide on in vitro human eosinophil migration.
Topics: Cell Movement; Chemotaxis; Drug Interactions; Enzyme Inhibitors; Eosinophils; Guanylate Cyclase; Humans; Imidazoles; N-Formylmethionine Leucyl-Phenylalanine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines | 2001 |
Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation.
Topics: Amidines; Animals; Antineoplastic Agents; Aorta, Thoracic; Benzylamines; Cell Respiration; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Interferon-gamma; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Rats; Rats, Wistar; Vasculitis | 2001 |
Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Carbachol; Cardiotonic Agents; Cesium; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Rate; Hypothalamus; Imidazoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Ornithine; Oxadiazoles; Parasympathetic Nervous System; Parasympatholytics; Propranolol; Quinoxalines; Sinoatrial Node; Stimulation, Chemical; Vagus Nerve | 2001 |
Relaxation and modulation of cyclic AMP production in response to atrial natriuretic peptides in guinea pig tracheal smooth muscle.
Topics: Adenylyl Cyclases; Animals; Apamin; Atrial Natriuretic Factor; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Natriuretic Peptide, C-Type; Nitroprusside; Oxadiazoles; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Quinoxalines; Rolipram; Trachea | 2001 |
Expression of inducible nitric oxide synthase depresses beta-adrenergic-stimulated calcium release from the sarcoplasmic reticulum in intact ventricular myocytes.
Topics: Animals; Calcium; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanidines; Guanylate Cyclase; Heart Failure; Heart Ventricles; Humans; Lipopolysaccharides; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Sarcoplasmic Reticulum | 2001 |
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Gene Expression Regulation; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitric Oxide; Oxadiazoles; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Atrial Natriuretic Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sheep; Transcription, Genetic | 2002 |
Electrical activity induced by nitric oxide in canine colonic circular muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Colon; Dogs; Electric Conductivity; Enteric Nervous System; Enzyme Inhibitors; Female; Gastrointestinal Motility; In Vitro Techniques; Indoles; Male; Membrane Potentials; Mitochondria; Muscle, Smooth; Nickel; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium; Quinoxalines; Uncoupling Agents | 2002 |
NO/cGMP signaling and HSP90 activity represses metamorphosis in the sea urchin Lytechinus pictus.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Female; Guanylate Cyclase; HSP90 Heat-Shock Proteins; Lactones; Macrolides; Male; Metamorphosis, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Sea Urchins; Signal Transduction | 2001 |
Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells.
Topics: Animals; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Glucose; Humans; Immunoblotting; Mink; Models, Biological; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Quinoxalines; Rats; RNA, Messenger; Signal Transduction; Thionucleotides; Thrombospondin 1; Time Factors; Transfection; Transforming Growth Factor beta | 2002 |
Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Hydrazones; In Vitro Techniques; Indomethacin; Male; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Thiophenes; Vasoconstriction; Vasodilator Agents | 2002 |
Effect of NO on EDHF response in rat middle cerebral arteries.
Topics: Adenosine Triphosphate; Animals; Biological Factors; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Long-Evans; Thionucleotides; Vasodilation | 2002 |
Role of catalase in the smooth muscle relaxant actions of sodium azide and cyanamide.
Topics: Amitrole; Animals; Aorta; Catalase; Cattle; Cyanamide; Electrochemistry; Enzyme Inhibitors; Hemoglobins; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitrogen Oxides; Oxadiazoles; Penis; Quinoxalines; Rats; Rats, Wistar; Sodium Azide; Spectrophotometry | 2002 |
Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats.
Topics: Acetylcholine; Animals; Antineoplastic Agents; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy Complications, Cardiovascular; Quinoxalines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
Nitric oxide induces resensitization of P2Y nucleotide receptors in cultured rat mesangial cells.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Glomerular Mesangium; Guanylate Cyclase; Intracellular Membranes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Osmolar Concentration; Oxadiazoles; Quinoxalines; Rats; Receptors, Purinergic P2; Ryanodine Receptor Calcium Release Channel | 2002 |
Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Biomarkers; Cell Adhesion Molecules; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Kinetics; Male; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphoproteins; Phosphorylation; Quinoxalines; Rabbits; Serine; Signal Transduction; Thionucleotides | 2002 |
Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall.
Topics: Adrenergic Fibers; Animals; Cholinergic Fibers; Chymotrypsin; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Muscle Relaxation; Neuropeptides; Nitrergic Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Perfusion; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Vagina | 2002 |
Vascular reactivity in intrapulmonary arteries of chicken embryos during transition to ex ovo life.
Topics: Animals; Animals, Newborn; Chick Embryo; Enzyme Inhibitors; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pulmonary Artery; Quinoxalines; Vasoconstriction; Vasodilation; Vasomotor System | 2002 |
Nitric oxide reduces blood pressure in the nucleus tractus solitarius: a real time electrochemical study.
Topics: Animals; Arginine; Biosensing Techniques; Blood Pressure; Bradycardia; Cats; Computer Systems; Electrochemistry; Enzyme Inhibitors; Extracellular Space; Female; Guanosine Monophosphate; Guanylate Cyclase; Hemoglobins; Hypertension; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pressoreceptors; Quinoxalines; Reflex; Sensitivity and Specificity; Solitary Nucleus; Tachycardia; Vagotomy | 2002 |
Effect of nitric oxide donors and noradrenaline on Ca2+ release sites and global intracellular Ca2+ in myocytes from guinea-pig small mesenteric arteries.
Topics: Animals; Calcium; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Intracellular Membranes; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2002 |
Sodium nitroprusside stimulates L-DOPA release from striatal tissue through nitric oxide and cGMP.
Topics: Animals; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Levodopa; Male; Melatonin; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Salicylic Acid; Superoxide Dismutase; Uric Acid | 2002 |
Pharmacology of the nitric oxide receptor, soluble guanylyl cyclase, in cerebellar cells.
Topics: Animals; Cerebellum; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Kinetics; Nitric Oxide; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2002 |
Okadaic acid inhibits relaxant neural transmission in rat gastric fundus in vitro.
Topics: Animals; Carbazoles; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; Gastrointestinal Agents; Hydrazines; In Vitro Techniques; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrogen Oxides; Okadaic Acid; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Purinones; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide | 2002 |
Dual effect of local application of nitric oxide donors in a model of incision pain in rats.
Topics: Animals; Disease Models, Animal; Diuretics, Osmotic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hindlimb; Hyperalgesia; Isosorbide; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Donors; Nitrites; Ointments; Oxadiazoles; Pain Threshold; Pain, Postoperative; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Time Factors | 2002 |
Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects.
Topics: Cell Movement; Chemokine CCL11; Chemokines, CC; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eosinophils; Guanylate Cyclase; Humans; Isoenzymes; Molsidomine; N-Formylmethionine Leucyl-Phenylalanine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Rhinitis, Allergic, Perennial; S-Nitroso-N-Acetylpenicillamine; Solubility | 2002 |
Roles of guanylate cyclase in responses to myogenic and neural nitric oxide in canine lower esophageal sphincter.
Topics: Animals; Dogs; Enzyme Inhibitors; Esophagogastric Junction; Female; Guanylate Cyclase; Male; Muscle Relaxation; Muscle Tonus; Nerve Fibers; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Potassium Channel Blockers; Quinoxalines; Tetraethylammonium Compounds | 2002 |
Effects of nitric oxide donors on cardiac contractility in wild-type and myoglobin-deficient mice.
Topics: Animals; Electric Stimulation; Enzyme Inhibitors; Female; Hydrazines; In Vitro Techniques; Male; Mice; Myocardial Contraction; Myocardium; Myoglobin; Nitric Oxide Donors; Nitrogen Oxides; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2002 |
Activation and up-regulation of spinal cord nitric oxide receptor, soluble guanylate cyclase, after formalin injection into the rat hind paw.
Topics: Animals; Behavior, Animal; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Guanylate Cyclase; Hindlimb; Hyperalgesia; Inflammation; Injections, Intraperitoneal; Injections, Spinal; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Pain Measurement; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, N-Methyl-D-Aspartate; Soluble Guanylyl Cyclase; Spinal Cord; Tissue Distribution; Up-Regulation | 2002 |
Role of cyclic guanosine monophosphate in late preconditioning in conscious rabbits.
Topics: Animals; Consciousness; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Ischemic Preconditioning, Myocardial; Kinetics; Male; Myocardial Infarction; Myocardial Stunning; Oxadiazoles; Quinoxalines; Rabbits | 2002 |
Cholinergic modulation of the basal L-type calcium current in ferret right ventricular myocytes.
Topics: Animals; Calcium Channels, L-Type; Carbachol; Cholinergic Agents; Electric Stimulation; Electrophysiology; Ferrets; Guanylate Cyclase; Heart Ventricles; In Vitro Techniques; Ion Channel Gating; Kinetics; Membrane Potentials; Muscarinic Agonists; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Patch-Clamp Techniques; Quinoxalines | 2002 |
Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro.
Topics: Animals; Aorta; Apamin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Male; Oxadiazoles; Pinacidil; Potassium Channel Blockers; Potassium Channels; Pyrazines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 2002 |
Carbon monoxide as a novel central pyrogenic mediator.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Body Temperature Regulation; Carbon Monoxide; Cerebrospinal Fluid; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hemin; Hypothalamus; Indomethacin; Injections, Intraventricular; Male; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley | 2002 |
Dilation of rat brain arterioles by hypercapnia in vivo can occur even after blockade of guanylate cyclase by ODQ.
Topics: Animals; Arterioles; Brain; Enzyme Inhibitors; Guanylate Cyclase; Hypercapnia; Male; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation | 2002 |
The mechanisms of peroxynitrite-induced relaxations in isolated rat anococcygeus muscle.
Topics: Animals; Antioxidants; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Peroxynitrous Acid; Potassium Channel Blockers; Quinoxalines; Rats | 2002 |
Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Cyclic GMP; Depression; Dimethyl Sulfoxide; Enzyme Inhibitors; Guanylate Cyclase; Imipramine; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Swimming | 2002 |
Effects of nitric oxide on P2Y receptor resensitization in spontaneously hypertensive rat mesangial cells.
Topics: Adenosine Triphosphate; Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Cytosol; Enzyme Inhibitors; Glomerular Mesangium; Guanylate Cyclase; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrogen Oxides; Osmolar Concentration; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Purinergic P2; Spermine | 2002 |
Arbutus unedo induces endothelium-dependent relaxation of the isolated rat aorta.
Topics: Animals; Aorta, Thoracic; Atropine; Carbachol; Dogs; Drug Interactions; Endothelium, Vascular; Ericaceae; In Vitro Techniques; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Norepinephrine; Oxadiazoles; Plant Extracts; Plant Roots; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 2002 |
Rat retinal tissue releases a vasorelaxing factor.
Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carotid Arteries; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Retina; Sarcoplasmic Reticulum; Thapsigargin; Vasodilation; Vasodilator Agents | 2002 |
Modulation by NO of acetylcholine release in the ileum of wild-type and NOS gene knockout mice.
Topics: Acetylcholine; Animals; Electric Stimulation; Enzyme Inhibitors; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Penicillamine; Quinoxalines | 2002 |
Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indicators and Reagents; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organic Cation Transport Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2002 |
Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling.
Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors | 2002 |
Involvement of NMDA receptors and a p21Ras-like guanosine triphosphatase in the constitutive activation of nuclear factor-kappa-B in cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alkyl and Aryl Transferases; Animals; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Down-Regulation; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Flavonoids; GTP Phosphohydrolases; Imidazoles; Immunohistochemistry; Neurons; NF-kappa B; Nitroarginine; Oxadiazoles; Polyenes; Polyunsaturated Alkamides; Proto-Oncogene Proteins p21(ras); Pyrazoles; Pyridines; Pyrimidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Transcription Factor RelA | 2002 |
Mechanism of nicotine-evoked release of 3H-noradrenaline in human cerebral cortex slices.
Topics: Adolescent; Adult; Arginine; Calcium; Calcium Channel Blockers; Cerebral Cortex; Dihydro-beta-Erythroidine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoxetine; Ganglionic Stimulants; Guanylate Cyclase; Humans; In Vitro Techniques; Indazoles; Male; Mecamylamine; Methylene Blue; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nicotine; Nicotinic Antagonists; Nitrendipine; Nitric Oxide Synthase; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Purinones; Quinoxalines; Tetrodotoxin; Tritium; Tubocurarine | 2002 |
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction | 2002 |
Role of the nitric oxide-cyclic GMP-K+ channel pathway in the antinociception induced by atrial natriuretic peptide (ANP) and diclofenac.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrial Natriuretic Factor; Charybdotoxin; Cyclic GMP; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain Measurement; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Tolbutamide | 2002 |
Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Free Radical Scavengers; Guanylate Cyclase; Inflammation; Linoleic Acids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Nitro Compounds; Oxadiazoles; Oxidation-Reduction; Oxyhemoglobins; Quinoxalines; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Vasodilation | 2002 |
Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP.
Topics: Animals; CD8-Positive T-Lymphocytes; Cells, Cultured; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation; Guanylate Cyclase; Humans; Male; Mice; Mice, Inbred BALB C; Models, Immunological; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Oxadiazoles; Polymerase Chain Reaction; Quinoxalines; Receptors, Interleukin; Receptors, Interleukin-12; Receptors, Interleukin-4; Signal Transduction; Th1 Cells; Th2 Cells | 2002 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Mechanisms underlying the hydrogen peroxide-induced, endothelium-independent relaxation of the norepinephrine-contraction in guinea-pig aorta.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Male; Methylene Blue; Myosin Light Chains; Nitroglycerin; Norepinephrine; Oxadiazoles; Phosphorylation; Purinones; Quinoxalines; Rats; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Rho-kinase inhibition blunts renal vasoconstriction induced by distinct signaling pathways in vivo.
Topics: Adenosine; Amides; Animals; Endothelins; Enzyme Inhibitors; Female; Guanylate Cyclase; Indoles; Intracellular Signaling Peptides and Proteins; Oxadiazoles; Peptide Fragments; Protein Kinase C; Protein Serine-Threonine Kinases; Purinergic P1 Receptor Agonists; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin; Renal Circulation; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasomotor System | 2003 |
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.
Topics: Animals; Guanylate Cyclase; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Penis; Pyrazoles; Pyridines; Quinoxalines; Rabbits | 2003 |
Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Muscle Relaxation; Neuropeptides; Nitric Oxide; Oxadiazoles; Quinoxalines; Radioimmunoassay; Starfish; Stomach | 2003 |
Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure.
Topics: Animals; Captopril; Ciliary Body; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intraocular Pressure; Iris; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitro Compounds; Nitrogen Oxides; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Rabbits; S-Nitrosothiols; Spermine; Swine; Time Factors | 2003 |
Level of haem oxygenase does not obligatorily reflect the sensitivity of PC12 cells to an oxidative shock induced by glutathione depletion.
Topics: Animals; Bilirubin; Buthionine Sulfoximine; Cell Death; Enzyme Activators; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemin; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; PC12 Cells; Pyrrolidines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Soluble Guanylyl Cyclase; Thiocarbamates | 2003 |
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
Topics: 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adipose Tissue, Brown; Animals; Cold Temperature; Cyclic GMP; DNA-Binding Proteins; DNA, Mitochondrial; Eating; Energy Metabolism; Female; HeLa Cells; High Mobility Group Proteins; Humans; Male; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Motor Activity; NF-E2-Related Factor 1; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nuclear Proteins; Nuclear Respiratory Factors; Oligonucleotides, Antisense; Oxadiazoles; Oxygen Consumption; Penicillamine; Quinoxalines; Rats; RNA, Messenger; Signal Transduction; Trans-Activators; Transcription Factors; U937 Cells; Weight Gain | 2003 |
5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding, Competitive; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrous Cycle; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oviducts; Oxadiazoles; Pituitary Adenylate Cyclase-Activating Polypeptide; Purinones; Quinoxalines; Radioligand Assay; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swine; Tritium; Vasoactive Intestinal Peptide | 2003 |
Nitric oxide (NO) primarily accounts for endothelium-dependent component of beta-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to isoprenaline.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Isoproterenol; Male; Mice; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Oxadiazoles; Propranolol; Quinoxalines; Receptors, Adrenergic, beta; Vasodilation | 2002 |
Effects of nitric oxide and cGMP on inhibin A and inhibin subunit mRNA levels from cultured rat granulosa cells.
Topics: Animals; Blotting, Northern; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Inhibins; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Effect of SNI-2011 on amylase secretion from parotid tissue in rats and in neuronal nitric oxide synthase knockout mice.
Topics: Alkaloids; Amylases; Animals; Azepines; Benzoates; Benzylamines; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carbazoles; Chelating Agents; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Gallic Acid; Genotype; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Indoles; Male; Mice; Mice, Knockout; Molsidomine; Muscarinic Agonists; Myosin-Light-Chain Kinase; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Parotid Gland; Penicillamine; Phosphodiesterase Inhibitors; Pilocarpine; Protein Kinase Inhibitors; Pyrroles; Pyrrolidinones; Quinoxalines; Quinuclidines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Type C Phospholipases | 2003 |
Effects of NCX 4050, a new NO donor, in rabbit and human corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cyclic Nucleotide Phosphodiesterases, Type 5; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Penile Erection; Penis; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones | 2003 |
Two distinct effects of cGMP on cytosolic Ca2+ concentration of rat pancreatic beta-cells.
Topics: 4-Aminopyridine; Animals; Calcium; Cyclic GMP; Cytosol; Dimethyl Sulfoxide; Enzyme Inhibitors; Glucose; Hydrazines; Hypoglycemic Agents; Islets of Langerhans; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Potassium; Potassium Channel Blockers; Quinoxalines; Rats; Tolbutamide | 2003 |
Hypoxia enhances a cGMP-independent nitric oxide relaxing mechanism in pulmonary arteries.
Topics: Animals; Cattle; Cell Hypoxia; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pulmonary Artery; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tetraethylammonium; Vasodilation | 2003 |
Cyclic GMP mediates influence of macula densa nitric oxide over tubuloglomerular feedback.
Topics: Animals; Citrulline; Cyclic GMP; Enzyme Inhibitors; Feedback, Physiological; Glomerular Filtration Rate; Guanylate Cyclase; Juxtaglomerular Apparatus; Male; Nephrons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Thiourea | 2003 |
Inhibition of high K+-evoked gamma-aminobutyric acid release by sodium nitroprusside in rat hippocampus.
Topics: Animals; Dithiothreitol; Ditiocarb; Free Radical Scavengers; gamma-Aminobutyric Acid; Guanylate Cyclase; Hippocampus; Male; Microdialysis; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Wistar | 2003 |
Antiapoptotic action of carbon monoxide on cultured vascular smooth muscle cells.
Topics: Animals; Apoptosis; Carbon Monoxide; Caspase 3; Caspases; Cells, Cultured; Cytokines; DNA Fragmentation; Enzyme Inhibitors; Imidazoles; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Pyridines; Quinoxalines; Rats | 2003 |
Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues.
Topics: Animals; Arginine; Bucladesine; Cyclic GMP; Dermis; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Subcutaneous; Male; Molsidomine; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Subcutaneous Tissue; Time Factors | 2003 |
Nitric oxide-dependent in vitro secretion of amylase from innervated or chronically denervated parotid glands of the rat in response to isoprenaline and vasoactive intestinal peptide.
Topics: Adrenergic beta-Agonists; Amylases; Animals; Arginine; Autonomic Denervation; Bethanechol; Enzyme Inhibitors; Female; Gastrointestinal Agents; Guanylate Cyclase; In Vitro Techniques; Isoproterenol; Neuropeptide Y; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Parasympathomimetics; Parotid Gland; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasoactive Intestinal Peptide | 2003 |
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Homeostasis; In Vitro Techniques; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; RNA, Messenger; Solubility | 2003 |
Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase.
Topics: Alkaloids; Aminoquinolines; Animals; Apoptosis; Burns; Carbazoles; Cell Division; Cells, Cultured; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Lymphocyte Activation; Male; Necrosis; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Skin; Spleen; T-Lymphocytes | 2003 |
NO- activates soluble guanylate cyclase and Kv channels to vasodilate resistance arteries.
Topics: Animals; Arteries; Benzoates; Culture Techniques; Cysteine; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Guanylate Cyclase; Imidazoles; Male; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Potassium; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Quinoxalines; Rats; Rats, Inbred WKY; Vascular Resistance; Vasodilation | 2003 |
Effect of nitric oxide on lung surfactant secretion.
Topics: Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Perfusion; Phosphatidylcholines; Pulmonary Alveoli; Pulmonary Surfactants; Quinoxalines; Rats; Rats, Sprague-Dawley; Spermine | 2003 |
Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase.
Topics: Benzoates; Diethylamines; Enzyme Activation; Guanylate Cyclase; Heme; Morpholines; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Pyrimidines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spectrophotometry, Ultraviolet | 2003 |
Nitric oxide has a role in regulating VLA-4-integrin expression on the human neutrophil cell surface.
Topics: Antibodies, Monoclonal; Cell Adhesion; Cell Adhesion Molecules; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Fibronectins; Guanylate Cyclase; Humans; Integrin alpha4beta1; Integrins; Macrophage-1 Antigen; Microtubules; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines | 2003 |
Effects of recombinant human relaxin on pregnant rat uterine artery and myometrium in vitro.
Topics: Adenine; Animals; Arteries; Dose-Response Relationship, Drug; Female; Gestational Age; Humans; Myometrium; NG-Nitroarginine Methyl Ester; Oxadiazoles; Oxytocin; Pregnancy; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Relaxin; Uterine Contraction | 2003 |
Abnormal activation of Na+-K+ pump in aortas from rats with endotoxaemia.
Topics: Animals; Aorta, Thoracic; Endotoxemia; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; Lipopolysaccharides; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Ouabain; Oxadiazoles; Phenylephrine; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase; Time Factors | 2003 |
A bicyclic monoterpene diol and UVB stimulate BRCA1 phosphorylation in human keratinocytes.
Topics: BRCA1 Protein; Cell Line; Dichlororibofuranosylbenzimidazole; DNA Repair; Dose-Response Relationship, Drug; Humans; Keratinocytes; Monoterpenes; Norbornanes; Oxadiazoles; Phosphorylation; Pyrimidine Dimers; Quinoxalines; Sirolimus; Time Factors; Ultraviolet Rays | 2003 |
Interaction between excitatory and inhibitory metabotropic pathways in the guinea-pig antrum.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Female; Guinea Pigs; Male; Muscle, Smooth; Neural Inhibition; Nitrates; Nitroarginine; Oxadiazoles; Pyloric Antrum; Quinoxalines; Synaptic Transmission | 2003 |
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Guanylate Cyclase; Male; Mesenteric Arteries; Mice; Mice, Inbred Strains; Mice, Knockout; Muscle Relaxation; Natriuretic Peptide, C-Type; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Nitroglycerin; Oxadiazoles; Phenylephrine; Polysaccharides; Quinoxalines; Receptors, Atrial Natriuretic Factor; Signal Transduction; Spermine | 2003 |
Activation of the phosphatidylinositol 3-kinase/protein kinase Akt pathway mediates nitric oxide-induced endothelial cell migration and angiogenesis.
Topics: Adenoviridae; Animals; Blotting, Western; Capillaries; Cell Adhesion; Cell Division; Cell Movement; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; DNA, Complementary; Dose-Response Relationship, Drug; Endothelium; Endothelium, Vascular; Enzyme Inhibitors; Gene Transfer Techniques; Humans; Ischemia; Laser-Doppler Flowmetry; Neovascularization, Pathologic; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Recombinant Proteins; S-Nitrosoglutathione; Time Factors | 2003 |
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells.
Topics: Animals; Aorta; Blotting, Western; Carbazoles; Cyclic GMP; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Free Radicals; Genes, Dominant; Glutathione Transferase; Indoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins p21(ras); Quinoxalines; Rabbits; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Transfection; Tyrosine | 2003 |
Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blotting, Western; Cells, Cultured; Chemokine CCL2; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Gene Expression Regulation; Guanylate Cyclase; Inflammation Mediators; Luciferases; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2003 |
Nitric oxide prevents UV-induced phosphorylation of the p53 tumor-suppressor protein at serine 46: a possible role in inhibition of apoptosis.
Topics: Apoptosis; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Mitogen-Activated Protein Kinases; Nitric Oxide; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Quinoxalines; Serine; Signal Transduction; Subcellular Fractions; Time Factors; Transcriptional Activation; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 2003 |
Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells.
Topics: Animals; Bronchi; Cattle; Cells, Cultured; Cilia; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Ethanol; Guanylate Cyclase; Nitric Oxide; Oxadiazoles; Quinoxalines; Thionucleotides | 2003 |
G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.
Topics: Animals; Arteries; Calcium; Cannabinoids; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endothelium; Endothelium, Vascular; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Humans; Indoles; Kinetics; Ligands; Male; Membrane Potentials; Oxadiazoles; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Resorcinols; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Umbilical Veins; Vasodilator Agents | 2003 |
Nitric oxide and cyclic GMP increase the expression of matrix metalloproteinase-9 in vascular smooth muscle.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclooxygenase 2; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; RNA, Messenger; Superoxide Dismutase | 2003 |
Influence of drugs acting on nitric oxide-dependent pathways on ethanol tolerance in rats.
Topics: Aminoquinolines; Animals; Cyclic GMP; Drug Tolerance; Enzyme Inhibitors; Ethanol; Guanylate Cyclase; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2003 |
Enhancement of endotoxin-induced vascular hyporeactivity to phenylephrine in the thoracic aortas of Mg-deficient rats ex vivo.
Topics: Amidines; Animals; Aorta, Thoracic; Benzylamines; Diet; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; In Vitro Techniques; Injections, Intraperitoneal; Interleukin-1; Lipopolysaccharides; Magnesium Deficiency; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; RNA, Messenger; Tumor Necrosis Factor-alpha | 2003 |
The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway.
Topics: Adenosine; Aorta, Thoracic; Basidiomycota; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Medicine, Chinese Traditional; Mycelium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Plant Extracts; Plants, Medicinal; Quinoxalines; Species Specificity; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2003 |
Burn-induced lung damage in rat is mediated by a nitric oxide/cGMP system.
Topics: Animals; Base Sequence; Burns; Cyclic GMP; Enzyme Inhibitors; Female; Gene Expression; Guanylate Cyclase; Lung; Lung Injury; Male; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Oxadiazoles; Peroxidase; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2003 |
Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury.
Topics: Administration, Inhalation; Animals; Blood Vessels; Carbon Monoxide; Carboxyhemoglobin; Corrosion Casting; Cytokines; Enzyme Inhibitors; Gases; Guanylate Cyclase; Inflammation Mediators; Intestine, Small; Ischemia; Male; Osmolar Concentration; Oxadiazoles; Plasminogen Activator Inhibitor 1; Platelet Endothelial Cell Adhesion Molecule-1; Quinoxalines; Rats; Rats, Inbred Lew; Regional Blood Flow; Reperfusion Injury; RNA, Messenger; Survival Analysis | 2003 |
Ca2+-activated K+ channels mediate relaxation of forearm veins in chronic renal failure.
Topics: Acetylcholine; Biological Factors; Enzyme Inhibitors; Female; Forearm; Humans; In Vitro Techniques; Kidney Failure, Chronic; Male; Middle Aged; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Potassium Channels, Calcium-Activated; Quinoxalines; Vasodilation; Vasodilator Agents; Veins | 2003 |
The effects of selective phosphodiesterase III and V inhibitors on adrenergic and non-adrenergic, non-cholinergic relaxation responses of guinea-pig pulmonary arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Adenosine; Animals; Arginine; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Synergism; Electric Stimulation; Guinea Pigs; Histamine; Isoproterenol; Male; Milrinone; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pulmonary Artery; Purinones; Quinoxalines; Receptors, Adrenergic; Receptors, Cholinergic; Signal Transduction; Tetrodotoxin; Theophylline | 2003 |
Role of sarcoplasmic reticulum in control of membrane potential and nitrergic response in opossum lower esophageal sphincter.
Topics: Animals; Anthracenes; Atropine; Azepines; Caffeine; Calcium; Chloride Channels; Enzyme Inhibitors; Esophagogastric Junction; Female; Guanethidine; In Vitro Techniques; Indoles; Male; Membrane Potentials; Muscle, Smooth; Myosin-Light-Chain Kinase; Nifedipine; Niflumic Acid; Nitric Oxide; Opossums; Oxadiazoles; Quinoxalines; Ryanodine; Sarcoplasmic Reticulum; Substance P; Tetraethylammonium | 2003 |
Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.
Topics: B-Lymphocytes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Herpesvirus 4, Human; Humans; Immunoglobulin G; Leukocytes, Mononuclear; Niacinamide; Nicorandil; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
A role for nitric oxide in hypoxia-induced activation of cardiac KATP channels in goldfish (Carassius auratus).
Topics: Action Potentials; Analysis of Variance; Animals; Diacetyl; Goldfish; Hypoxia; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Penicillamine; Potassium Channels; Quinoxalines; Sarcolemma | 2003 |
Differential effects of a selective inhibitor of soluble guanylyl cyclase on global and regional hemodynamics during canine endotoxic shock.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Enzyme Inhibitors; Guanylate Cyclase; Hemodynamics; Lipopolysaccharides; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Regional Blood Flow; Renal Blood Flow, Effective; Shock, Septic; Soluble Guanylyl Cyclase; Vascular Resistance | 2003 |
Role of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Female; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Regional Blood Flow; Sexual Behavior, Animal; Sildenafil Citrate; Sulfones; Vagina | 2003 |
The roles of cyclic adenosine monophosphate- and cyclic guanosine monophosphate-dependent protein kinase pathways in hydrogen peroxide-induced contractility of microvascular lung pericytes.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydrogen Peroxide; Isoquinolines; Lung; Male; Muscle Contraction; Oxadiazoles; Pericytes; Quinoxalines; Rats; Rats, Sprague-Dawley; Respiratory Distress Syndrome; Sepsis; Sulfonamides | 2003 |
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Topics: Animals; Apoptosis; Carbazoles; Cell Line, Transformed; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; DNA Fragmentation; Enzyme Inhibitors; Epithelial Cells; Female; Guanylate Cyclase; Indoles; Oxadiazoles; Oxazines; Quinoxalines; Signal Transduction; Uterus | 2003 |
Activation of nitric oxide-cyclic guanosine monophosphate signaling in kidney by extracorporeal shock wave therapy.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Kidney; Lithotripsy; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxadiazoles; Quinoxalines; Rabbits; Signal Transduction | 2003 |
Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on rat aorta.
Topics: Animals; Aorta, Thoracic; Asteraceae; Brazil; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethanol; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Oxadiazoles; Phenylephrine; Plant Extracts; Plant Roots; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasoconstriction; Vasodilation | 2004 |
Pertussis toxin-sensitive G protein but not NO/cGMP pathway mediates the negative inotropic effect of carbachol in adult rat cardiomyocytes.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; GTP-Binding Proteins; Injections, Intraperitoneal; Isoproterenol; Male; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Time Factors | 2004 |
Heterogeneity of neuronal and smooth muscle receptors involved in the VIP- and PACAP-induced relaxations of the pig intravesical ureter.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Apamin; Capsaicin; Charybdotoxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Female; Guanylate Cyclase; Male; Muscle, Smooth; Neurons, Afferent; Neuropeptide Y; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-Conotoxin GVIA; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium Channels, Calcium-Activated; Quinoxalines; Receptors, Calcitonin Gene-Related Peptide; Receptors, Peptide; Receptors, Vasoactive Intestinal Peptide; Rolipram; Sensory Receptor Cells; Swine; Tetraethylammonium; Ureter; Vasoactive Intestinal Peptide | 2004 |
Nitric oxide decreases the biological activity of norepinephrine resulting in altered vascular tone in the rat mesenteric arterial bed.
Topics: Animals; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Oxadiazoles; Perfusion; Pressure; Quinoxalines; Rats; Vasomotor System | 2004 |
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide | 2003 |
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Cardiomyopathy, Dilated; Cricetinae; Cytoskeletal Proteins; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Enalapril; Endothelium, Vascular; Enzyme Inhibitors; Heart Failure; Hemodynamics; Male; Membrane Glycoproteins; Mesocricetus; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Oxadiazoles; Quinoxalines; Rabbits; Sarcoglycans; Ultrasonography; Vasoconstriction; Ventricular Remodeling | 2004 |
Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin.
Topics: Adolescent; Adult; Child; Cyclic GMP; Drug Evaluation, Preclinical; Electric Stimulation; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penis; Phenylephrine; Piperazines; Priapism; Purines; Quinoxalines; Scorpion Venoms; Second Messenger Systems; Sildenafil Citrate; Sodium Channel Blockers; Sulfones; Tetrodotoxin | 2004 |
Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2 levels: essential role of cGMP.
Topics: Animals; Animals, Newborn; Antioxidants; Aorta, Thoracic; Catalase; Cell Movement; Cells, Cultured; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Muscle, Smooth, Vascular; NADPH Oxidases; Nitric Oxide; Oxadiazoles; Oxidants; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Sprague-Dawley | 2004 |
Evidence that nitroprusside stimulates glucose uptake in isolated rat cardiomyocytes via mitogen-activated protein kinase.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferricyanides; Flavonoids; Glucose; Imidazoles; Male; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Spermine | 2003 |
Vasodilatory mechanism of unoprostone isopropyl on isolated rabbit ciliary artery.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Antihypertensive Agents; Ciliary Arteries; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Histamine; Isometric Contraction; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle, Smooth, Vascular; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rabbits; Vasodilation | 2004 |
Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells.
Topics: Animals; Aorta; Cattle; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Down-Regulation; Enzyme Activators; Enzyme Inhibitors; Humans; Indazoles; Interleukin-1; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroso Compounds; Nucleotides, Cyclic; Oxadiazoles; Quinoxalines; Recombinant Proteins; Tumor Necrosis Factor-alpha | 2004 |
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume | 2004 |
[Effects of icariin on intracavernosal pressure and systematic arterial blood pressure of rat].
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Flavonoids; Nitroarginine; Oxadiazoles; Papaverine; Penile Erection; Piperazines; Pressure; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones | 2004 |
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Topics: Adenosine Triphosphate; Analgesics; Animals; Arginine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Indoles; Male; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis.
Topics: Animals; Blotting, Northern; Blotting, Western; Cyclic GMP; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Lysine; Male; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Triazenes; Up-Regulation | 2003 |
Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Topics: Adrenalectomy; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Denervation; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Guanylate Cyclase; Hypertension; Ion Transport; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Natriuresis; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sodium; Soluble Guanylyl Cyclase; Thionucleotides | 2004 |
NMDA receptors in nucleus tractus solitarii are linked to soluble guanylate cyclase.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoquinolines; Animals; Baroreflex; Biotransformation; Blood Pressure; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; In Vitro Techniques; Male; Microinjections; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Stereotaxic Techniques | 2004 |
Influence of nitric oxide donors and peroxynitrite on the contractile effect and concentration of norepinephrine.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Rats; Rats, Sprague-Dawley | 2004 |
Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade.
Topics: Animals; Cyclic GMP; Drug Combinations; Dura Mater; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Male; Mechanoreceptors; Neural Inhibition; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nociceptors; Oxadiazoles; Physical Stimulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thionucleotides | 2004 |
Involvement of NO/cGMP pathway in toluene-induced locomotor hyperactivity in female rats.
Topics: Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Hyperkinesis; Injections, Intraperitoneal; Motor Activity; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toluene | 2004 |
Procyanidins from Vitis vinifera seeds display cardioprotection in an experimental model of ischemia-reperfusion damage.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta; Biflavonoids; Cardiotonic Agents; Catechin; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanylate Cyclase; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Oxadiazoles; Proanthocyanidins; Quinoxalines; Rabbits; Seeds; Vasodilator Agents; Vitis | 2003 |
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
Topics: Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Interleukin-6; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy, Animal; Progesterone; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2004 |
Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder | 2004 |
5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.
Topics: Analysis of Variance; Animals; Benzamides; Biphenyl Compounds; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Membrane Potentials; Muscimol; Neural Inhibition; Neurons; omega-Agatoxin IVA; omega-Conotoxin GVIA; Oxadiazoles; Patch-Clamp Techniques; Pertussis Toxin; Phosphinic Acids; Piperazines; Presynaptic Terminals; Propanolamines; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1B; Septal Nuclei; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission | 2004 |
Peripheral neuronal nitric oxide synthase activity mediates the antinociceptive effect of Crotalus durissus terrificus snake venom, a delta- and kappa-opioid receptor agonist.
Topics: Analgesics; Animals; Crotalid Venoms; Crotalus; Dinoprostone; Drug Antagonism; Enzyme Inhibitors; Hyperalgesia; Indazoles; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 2004 |
Role of cyclic GMP in nitrous-oxide-induced anxiolytic-like behavior in the mouse light-dark exploration test.
Topics: Animals; Anxiety; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Male; Mice; Nitrous Oxide; Oxadiazoles; Periodicity; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2004 |
The permissive role of endothelial NO in CO-induced cerebrovascular dilation.
Topics: Animals; Arterioles; Carbon Monoxide; Cerebral Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Nitroprusside; Oxadiazoles; Pia Mater; Potassium Channel Blockers; Quinoxalines; Swine; Tetraethylammonium; Vasodilation | 2004 |
Nitric oxide mediates ultrasound-induced hypoxia-inducible factor-1alpha activation and vascular endothelial growth factor-A expression in human osteoblasts.
Topics: Calcium; Cell Line; Dinoprostone; Endothelial Cells; Guanylate Cyclase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Osteoblasts; Oxadiazoles; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; Transcription, Genetic; Ultrasonics; Vascular Endothelial Growth Factor A | 2004 |
Nitric oxide donor induces temporal and dose-dependent reduction of gene expression in human endothelial cells.
Topics: Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oligonucleotide Array Sequence Analysis; Oxadiazoles; Quinoxalines; Time Factors; Transcription, Genetic | 2004 |
Nitric oxide modulates local reflexes of the tailfan of the crayfish.
Topics: Analysis of Variance; Animals; Arginine; Astacoidea; Cyclic GMP; Cyclic N-Oxides; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Free Radical Scavengers; Imidazoles; In Vitro Techniques; Male; Muscles; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Picolines; Quinoxalines; Reflex; Thionucleotides | 2004 |
Nitric oxide regulates the levels of cGMP accumulation in the cricket brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Gryllidae; Guanylate Cyclase; Immunohistochemistry; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sodium Chloride; Soluble Guanylyl Cyclase | 2004 |
Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT).
Topics: Animals; Biological Transport; Catalase; Chlorocebus aethiops; COS Cells; Culture Media; Cysteine; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Guanylate Cyclase; Humans; Hydroxocobalamin; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Nitric Oxide Donors; Nitro Compounds; Oxadiazoles; Peroxynitrous Acid; Piperazines; Quinoxalines; Serotonin; Serotonin Plasma Membrane Transport Proteins; Superoxide Dismutase; Transfection | 2004 |
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Endocardium; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Hemodynamics; Hypertrophy, Left Ventricular; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium Channels; Quinoxalines; Swine; Vascular Resistance; Vasodilation | 2004 |
Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver.
Topics: Acetylcholine; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Insulin Resistance; Liver; Male; Molsidomine; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Portal Vein; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
The soluble guanylyl cyclase inhibitor ODQ, 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, dose-dependently reduces the threshold for isoflurane anesthesia in rats.
Topics: Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Isoflurane; Male; N-Methylaspartate; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2004 |
Effects of a novel platelet nitric oxide donor (LA816), aspirin, clopidogrel, and combined therapy in inhibiting flow- and lesion-dependent thrombosis in the porcine ex vivo model.
Topics: Adenosine Diphosphate; Amino Acids; Animals; Aspirin; Benzoates; Blood Pressure; Clopidogrel; Collagen; Cyclooxygenase Inhibitors; Drug Evaluation; Drug Therapy, Combination; Fibrinolytic Agents; Free Radical Scavengers; Guanylate Cyclase; Heart Rate; Hemorheology; Imidazoles; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Quinoxalines; Random Allocation; Receptors, Purinergic P2Y12; rhoA GTP-Binding Protein; Sus scrofa; Thrombosis; Ticlopidine | 2004 |
Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.
Topics: Acetylcholine; Administration, Oral; Alcohol Drinking; Animals; Apamin; Atropine; Blood Pressure; Bradykinin; Brazil; Charybdotoxin; Clonidine; Deoxycholic Acid; Drug Therapy, Combination; Endothelium, Vascular; Flavonoids; Glyburide; Guanylate Cyclase; Hypertension; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Norepinephrine; Oxadiazoles; Perfusion; Phenols; Polyphenols; Potassium Chloride; Pressure; Pyrilamine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Wine; Yohimbine | 2004 |
Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier.
Topics: Blood-Brain Barrier; Capillary Permeability; Cells, Cultured; Cyclic GMP; Cytokines; Electric Impedance; Endothelial Cells; Enzyme Inhibitors; Humans; Immunohistochemistry; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Quinoxalines; Signal Transduction | 2004 |
Nitrergic mechanisms mediating inhibitory control of longitudinal smooth muscle contraction in mouse small intestine.
Topics: Animals; Atropine; Electric Stimulation; Enzyme Inhibitors; Gastrointestinal Motility; Guanylate Cyclase; Ileum; Jejunum; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Phentolamine; Propranolol; Quinoxalines | 2004 |
Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cyclic GMP; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Hemoglobins; Hypertension, Renovascular; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Vasodilator Agents | 2004 |
Decreased aortic smooth muscle contraction in a rat model of multibacterial sepsis.
Topics: Animals; Aorta; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Sepsis; Soluble Guanylyl Cyclase | 2004 |
The role of nitric oxide on contractile impairment during endotoxemia in rat diaphragm muscle.
Topics: Animals; Caffeine; Diaphragm; Endotoxemia; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Indazoles; Lipopolysaccharides; Male; Muscle Contraction; Neuromuscular Nondepolarizing Agents; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Ryanodine; Tubocurarine; Vasodilator Agents; Verapamil | 2004 |
S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma.
Topics: Adult; Animals; Ascorbic Acid; Copper; Female; Humans; Mesenteric Arteries; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxidative Stress; Phenylephrine; Pre-Eclampsia; Pregnancy; Quinoxalines; Serum Albumin, Bovine; Vasodilation | 2005 |
Nitric oxide-cyclic GMP contributes to abnormal activation of Na+-K+-ATPase in the aorta from rats with endotoxic shock.
Topics: Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Male; Nitrates; Nitric Oxide; Ouabain; Oxadiazoles; Potassium; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Nitric oxide-dependent and nitric oxide-independent transcriptional responses to high shear stress in endothelial cells.
Topics: Binding Sites; Cyclic GMP; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; High Mobility Group Proteins; Humans; Immediate-Early Proteins; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nuclear Proteins; Oxadiazoles; Quinoxalines; SOX9 Transcription Factor; SOXD Transcription Factors; Stress, Mechanical; Transcription Factors; Transcription, Genetic | 2005 |
Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of fallopian tube contractility.
Topics: Adult; Cyclic GMP; Enzyme Inhibitors; Fallopian Tubes; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Methylene Blue; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Spermine | 2004 |
Lack of synergistic effect of molsidomine and sildenafil on development of pulmonary hypertension in chronic hypoxic rats.
Topics: Acetylcholine; Actins; Animals; Atrial Natriuretic Factor; Body Weight; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; Heart Ventricles; Hypertension, Pulmonary; Hypoxia; Lung; Male; Molsidomine; Muscle, Smooth; Oxadiazoles; Piperazines; Pulmonary Artery; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Systole; Vasodilation; Vasodilator Agents | 2005 |
The vasorelaxing effect of CGRP and natriuretic peptides in isolated bovine retinal arteries.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptides; Nitroarginine; Oxadiazoles; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Regional Blood Flow; Retinal Artery; Vasodilation | 2005 |
BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Oxadiazoles; Pulmonary Artery; Pyrazoles; Pyridines; Quinoxalines; Rubidium Radioisotopes; Serotonin; Sheep; Sodium-Potassium-Exchanging ATPase; Vasoconstriction; Vasodilation | 2005 |
Hemin induces active chloride secretion in Caco-2 cells.
Topics: Caco-2 Cells; Carbon Monoxide; Chlorides; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Epithelium; Hemin; Homeostasis; Humans; Ouabain; Oxadiazoles; Quinoxalines; Sodium; Water-Electrolyte Balance | 2005 |
Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.
Topics: Acute-Phase Proteins; Animals; Apoptosis; Carrier Proteins; Cells, Cultured; Culture Media, Conditioned; Cyclic GMP; Cytokines; DNA; Endotoxins; Enzyme Inhibitors; Hepatocytes; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver; Male; Membrane Glycoproteins; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Toll-Like Receptors | 2005 |
Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes.
Topics: Animals; Caffeine; Carbachol; Chelating Agents; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Egtazic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Membrane Potentials; Muscarinic Agonists; Muscle Contraction; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Quinoxalines; Type C Phospholipases | 2005 |
Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test.
Topics: Analgesics; Animals; Apamin; Charybdotoxin; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Injections, Subcutaneous; Oxadiazoles; Pain; Pain Measurement; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tetraethylammonium; Time Factors; Tolbutamide | 2005 |
Release of arginine, glutamate and glutamine in the hippocampus of freely moving rats: Involvement of nitric oxide.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arginine; Behavior, Animal; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutamine; Hippocampus; Indazoles; Male; Microdialysis; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Wakefulness | 2005 |
Inhibitory influence of chromogranin A N-terminal fragment (vasostatin-1) on the spontaneous contractions of rat proximal colon.
Topics: Animals; Apamin; Calreticulin; Chromogranin A; Chromogranins; Colon; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Tract; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Peptide Fragments; Peptides; Pressure; Protein Structure, Tertiary; Quinoxalines; Rats; Rats, Wistar; Recombinant Proteins; Tetrodotoxin; Time Factors | 2005 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; Guanylate Cyclase; Hindlimb; Injections, Spinal; Injections, Subcutaneous; Methiothepin; Naloxone; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organic Chemicals; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Scorpion Venoms | 2005 |
Formation of releasable NO stores by S-nitrosoglutathione in arteries exhibiting tolerance to glyceryl-trinitrate.
Topics: Acetylcysteine; Analysis of Variance; Animals; Aorta, Thoracic; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Nitric Oxide; Nitrogen Oxides; Nitroglycerin; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thionucleotides; Vasoconstriction; Vasodilation | 2005 |
Nitric oxide modulates peristaltic muscle activity associated with fluid circulation in the sea pansy Renilla koellikeri.
Topics: Animals; Anthozoa; Body Fluids; California; Guanidines; Immunohistochemistry; Indazoles; Muscle Contraction; Muscles; Neurites; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peristalsis; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2005 |
Endothelial mechanisms underlying responses to acetylcholine in the horse deep dorsal penile vein.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Horses; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Phenylephrine; Potassium; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Sodium Nitrite; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Veins | 2005 |
Differential effects of 5-HT2C receptor ligands on place conditioning and locomotor activity in rats.
Topics: Aminopyridines; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Indoles; Ligands; Male; Motor Activity; Oxadiazoles; Piperazines; Pyrazines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT2C; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Time Factors | 2005 |
Dual impact of a nitric oxide donor, GEA 3175, in human pulmonary smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Albuterol; Bronchi; Bronchodilator Agents; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Peptides; Pulmonary Artery; Quinoxalines; Triazoles; Vasoconstrictor Agents; Vasodilation | 2005 |
Nitric oxide reduces T lymphocyte adhesion to human brain microvessel endothelial cells via a cGMP-dependent pathway.
Topics: Brain; Cell Adhesion; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; E-Selectin; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; Humans; Intercellular Adhesion Molecule-1; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Endothelial Cell Adhesion Molecule-1; Quinoxalines; Signal Transduction; T-Lymphocytes; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Biphasic neurogenic vasodilatation in the bovine intraocular long posterior ciliary artery: involvement of nitric oxide and an additional unidentified neurotransmitter.
Topics: Animals; Cattle; Ciliary Arteries; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Muscle, Smooth, Vascular; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide; Oxadiazoles; Quinoxalines; Tetrodotoxin; Vasodilation | 2005 |
Peroxynitrite-induced relaxation in isolated rat aortic rings and mechanisms of action.
Topics: Animals; Aorta; Calcium Chloride; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; In Vitro Techniques; Male; Marine Toxins; Methylene Blue; Oxadiazoles; Oxazoles; Peroxynitrous Acid; Phenylephrine; Piperazines; Potassium; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2005 |
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets.
Topics: Adenosine; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Humans; Milrinone; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Thrombin; Time Factors; Triazoles | 2005 |
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits.
Topics: Acetophenones; Allopurinol; Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypercholesterolemia; In Vitro Techniques; Male; Muscle Relaxation; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Onium Compounds; Oxadiazoles; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Rotenone; Sildenafil Citrate; Sulfones; Superoxides; Uncoupling Agents; Xanthine Oxidase | 2005 |
Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydroxylamine; Imidazoles; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Vasodilation; Vasodilator Agents | 2005 |
Nitric oxide increases carbon monoxide production by piglet cerebral microvessels.
Topics: Animals; Animals, Newborn; Carbon Monoxide; Cerebrovascular Circulation; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Microcirculation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Swine | 2005 |
Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cells, Cultured; Cyclic GMP; Endothelial Cells; Guanylate Cyclase; Male; Membrane Glycoproteins; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Oxadiazoles; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Purines; Quinoxalines; Sildenafil Citrate; Sulfones; Superoxides; Swine; Thionucleotides | 2005 |
Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells.
Topics: Cell Line; Cell Membrane; Cell Membrane Permeability; Chlorides; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Epithelial Cells; Fluorescent Antibody Technique; Guanylate Cyclase; Humans; Intestinal Mucosa; Intestines; Isoquinolines; Nitric Oxide; Nitric Oxide Donors; Nocodazole; Oxadiazoles; Quinoxalines; Sulfonamides | 2005 |
Mitochondrial nitric oxide mediates decreased vulnerability of hippocampal neurons from immature animals to NMDA.
Topics: Animals; Animals, Newborn; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Clonazepam; Hippocampus; Indazoles; Ion Transport; Mitochondria; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxadiazoles; Oxygen; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Ruthenium Compounds; Thiazepines | 2005 |
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles | 2006 |
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.
Topics: Animals; Carbazoles; Cyclic GMP; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; Hypothalamus, Anterior; Indazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Rats; Suramin; Tyrosine 3-Monooxygenase | 2005 |
Roles of nitric oxide and prostacyclin in triethyleneglycol dimethacrylate (TEGDMA)-induced vasorelaxation.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta, Thoracic; Composite Resins; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Guanylate Cyclase; Male; Nitric Oxide; Nitrites; Oxadiazoles; Polyethylene Glycols; Polymethacrylic Acids; Quinoxalines; Rats; Rats, Inbred WKY; Vasodilator Agents | 2006 |
Lysozyme binding to endocardial endothelium mediates myocardial depression by the nitric oxide guanosine 3',5' monophosphate pathway in sepsis.
Topics: Animals; Cell Membrane; Cyclic GMP; Dogs; Endocardium; Endothelium; In Vitro Techniques; Muramidase; Myocardial Contraction; Myocardium; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Sepsis | 2005 |
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Reaction Time; Spinal Cord; Time Factors; Vincristine | 2005 |
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Injections, Subcutaneous; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Tetrahydroisoquinolines; Time Factors | 2005 |
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors | 2005 |
Lack of the nitric oxide-cyclic GMP-potassium channel pathway for the antinociceptive effect of intrathecal zaprinast in a rat formalin test.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analgesics; Animals; Cyclic GMP; Formaldehyde; Glyburide; Injections, Spinal; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Potassium Channels; Purinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2005 |
Negative inotropic effect of low-dose ethanol in mouse ventricular myocytes is mediated by activation of endothelial nitric oxide synthase.
Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Ethanol; Guanylate Cyclase; In Vitro Techniques; Mice; Mice, Knockout; Myocardial Contraction; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines | 2005 |
Relaxant effect of adrenomedullin on bovine isolated iris sphincter muscle under resting conditions.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Dideoxyadenosine; Enzyme Inhibitors; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Nitroarginine; Oxadiazoles; Peptide Fragments; Peptides; Pupil; Quinoxalines; Signal Transduction | 2005 |
Soluble guanylyl cyclase expression is reduced in allergic asthma.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchoconstrictor Agents; Enzyme Inhibitors; Guanylate Cyclase; Homeostasis; Hypersensitivity; Isoenzymes; Methacholine Chloride; Mice; Ovalbumin; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Soluble Guanylyl Cyclase | 2006 |
Desferoxamine and ethyl-3,4-dihydroxybenzoate protect myocardium by activating NOS and generating mitochondrial ROS.
Topics: Androstadienes; Animals; ATP-Binding Cassette Transporters; Cyclic GMP-Dependent Protein Kinases; Deferoxamine; Enzyme Activation; Female; Glyburide; Guanylate Cyclase; Hemodynamics; Hydroxybenzoates; KATP Channels; Male; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Potassium Channels; Potassium Channels, Inwardly Rectifying; Procollagen-Proline Dioxygenase; Proto-Oncogene Proteins c-akt; Quinoxalines; Rabbits; Reactive Oxygen Species; Wortmannin | 2006 |
Impact of caveolin-1 knockout on NANC relaxation in circular muscles of the mouse small intestine compared with longitudinal muscles.
Topics: Animals; Apamin; Autonomic Nervous System; Caveolin 1; Immunohistochemistry; In Vitro Techniques; Jejunum; Male; Mice; Mice, Knockout; Microscopy, Electron; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Synaptic Transmission; Tetrodotoxin | 2006 |
Mechanisms underlying relaxation of rabbit aorta by BAY 41-2272, a nitric oxide-independent soluble guanylate cyclase activator.
Topics: Animals; Aorta; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Signal Transduction; Sildenafil Citrate; Sulfones; Vasodilation | 2005 |
Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery.
Topics: Amides; Animals; Blotting, Western; Celiac Artery; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Guanine Nucleotide Exchange Factors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Biguanides; Biphenyl Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Hindlimb; In Vitro Techniques; Infusions, Intravenous; Male; Methiothepin; Oxadiazoles; Perfusion; Piperazines; Pressure; Quinoxalines; Rats; Rats, Wistar; Ritanserin; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Serotonin 5-HT3 Receptor Agonists; Serotonin Agents; Serotonin Antagonists; Serotonin Receptor Agonists; Tryptamines; Vasoconstriction | 2005 |
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroquinones; Iliac Artery; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Phenylephrine; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinoxalines; Serine; Signal Transduction; Swine; Triazoles; Tyrosine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aged; Aged, 80 and over; Animals; Basilar Artery; Blotting, Western; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Humans; Hydrolysis; In Vitro Techniques; Infant; Male; Morpholines; Muscle, Smooth, Vascular; Nitroprusside; Oxadiazoles; Piperazines; Purines; Pyrazoles; Pyrimidines; Pyrimidinones; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2005 |
Role of pentose phosphate pathway-derived NADPH in hypoxic pulmonary vasoconstriction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 6-Aminonicotinamide; Androsterone; Animals; Enzyme Inhibitors; Glucose-6-Phosphate; Glucosephosphate Dehydrogenase; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Lung; Male; NADP; Nitrates; Nitrites; Oxadiazoles; Pentose Phosphate Pathway; Perfusion; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Vascular Resistance; Vasoconstriction | 2006 |
Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO.
Topics: Animals; Arterioles; Bacterial Infections; Blotting, Western; Connexins; Gap Junction alpha-4 Protein; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Skeletal; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Vasoconstriction | 2006 |
Gap junction coupling and apoptosis in GFSHR-17 granulosa cells.
Topics: Apoptosis; Cell Line; DNA; DNA Damage; Dose-Response Relationship, Drug; Female; Gap Junctions; Granulosa Cells; HeLa Cells; Humans; Oxadiazoles; Quinoxalines | 2005 |
Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Blotting, Western; Carotid Arteries; Cell Adhesion; Cell Line; Chemokine CCL2; Cyclic GMP; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Hydrolyzable Tannins; In Vitro Techniques; Intercellular Adhesion Molecule-1; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Paeonia; Plant Bark; Plant Roots; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2005 |
Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation.
Topics: Adenoviridae; Animals; Calcium Signaling; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; Hydrazines; Hypertension, Portal; Liver; Male; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Transduction, Genetic | 2006 |
Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.
Topics: Adenoviridae; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Half-Life; Humans; Mutation; Ovarian Neoplasms; Oxadiazoles; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Quinoxalines; RNA, Small Interfering; Serine; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Streptozocin; Sulfones; Time Factors | 2005 |
Relaxant effect of sildenafil in the rabbit basilar artery.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Rabbits; Signal Transduction; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2006 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tadalafil; Tetrodotoxin | 2006 |
Knockdown of arginase I restores NO signaling in the vasculature of old rats.
Topics: Acetylcholine; Aging; Animals; Aorta; Arginase; Arginine; Calcium; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Synthase; Oligonucleotides, Antisense; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Up-Regulation; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Analysis of the mechanisms underlying the vasorelaxant action of angiotensin II in the isolated rat carotid.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Carotid Arteries; Dose-Response Relationship, Drug; Drug Antagonism; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptide Fragments; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Saralasin; Vasoconstrictor Agents; Vasodilation | 2006 |
Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms.
Topics: Animals; Basilar Artery; Brain Stem; Calcium Chloride; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Ouabain; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin; Sildenafil Citrate; Sulfones; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Chronic CO levels have [corrected] a beneficial effect on vascular relaxation in diabetes.
Topics: Acetylcholine; Animals; Aorta; Biliverdine; Blotting, Western; Carbon Monoxide; Chromium; Densitometry; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Guanylate Cyclase; Heme; Immunohistochemistry; Male; Mesoporphyrins; Muscle Contraction; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Oxadiazoles; Oxidative Stress; Protoporphyrins; Pyrazines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Time Factors | 2006 |
Treatment with CO-RMs during cold storage improves renal function at reperfusion.
Topics: Animals; Carbon Monoxide; Cold Temperature; Kidney; Male; Mitochondria; Organ Preservation; Oxadiazoles; Oxygen Consumption; Quinoxalines; Rabbits; Reperfusion Injury | 2006 |
Photoimmunoprotection by UVA (320-400 nm) radiation is determined by UVA dose and is associated with cutaneous cyclic guanosine monophosphate.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Dermatitis, Contact; Dose-Response Relationship, Radiation; Enzyme Activation; Female; Guanylate Cyclase; Immune Tolerance; Mice; Mice, Inbred Strains; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Sildenafil Citrate; Skin; Sulfones; Ultraviolet Rays | 2006 |
Nitric oxide in B6 mouse and nitric oxide-sensitive soluble guanylate cyclase in cat modulate acetylcholine release in pontine reticular formation.
Topics: Acetylcholine; Animals; Arousal; Cats; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; Male; Mice; Mice, Inbred Strains; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Pons; Quinoxalines; Signal Transduction; Sleep; Time Factors | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Furoxan derivatives as cytotoxic agents: preliminary in vivo antitumoral activity studies.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Oxadiazoles; Quinoxalines; Sarcoma, Experimental | 2006 |
The nitric oxide-guanosine 3',5'-cyclic monophosphate pathway regulates dopamine efflux in the medial preoptic area and copulation in male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Copulation; Cyclic GMP; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Guanosine Monophosphate; Homovanillic Acid; Male; Microdialysis; Models, Biological; Nitric Oxide; Oxadiazoles; Preoptic Area; Quinoxalines; Rats; Rats, Long-Evans; Signal Transduction | 2006 |
Nitric oxide donor-induced persistent inhibition of cell adhesion protein expression and NFkappaB activation in endothelial cells.
Topics: Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cysteine; Endothelial Cells; Guanylate Cyclase; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2006 |
Renal vascular responses to CORM-A1 in the mouse.
Topics: Animals; Boranes; Carbon Monoxide; Carbonates; Carboxyhemoglobin; Female; Guanylate Cyclase; In Vitro Techniques; Kidney; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Potassium Channels, Calcium-Activated; Quinoxalines; Renal Artery; Renal Circulation; Vascular Resistance; Vasodilation | 2006 |
Direct effects of nitric oxide on histamine release from rat enterochromaffin-like cells.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enterochromaffin-like Cells; Enzyme Inhibitors; Gastrins; Guanylate Cyclase; Histamine; Histamine Release; Male; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Oxadiazoles; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley | 2006 |
Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients.
Topics: Cell Movement; Cells, Cultured; Chemotaxis; Diffusion; Endothelial Cells; Endothelium, Vascular; Guanylate Cyclase; Humans; Hydrazines; Neovascularization, Physiologic; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Triazenes; Volatilization | 2006 |
Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Hydrazines; Membrane Potentials; Mitochondria; Movement; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Prosencephalon; Quinoxalines; Rats; Time Factors | 2006 |
Mechanisms underlying the vasorelaxing effects of butylidenephthalide, an active constituent of Ligusticum chuanxiong, in rat isolated aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta, Thoracic; Calcium; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Ligusticum; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Phthalic Anhydrides; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
The nitric oxide synthesis/pathway mediates the inhibitory serotoninergic responses of the pressor effect elicited by sympathetic stimulation in diabetic pithed rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Blood Pressure; Diabetes Mellitus, Experimental; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Receptor Agonists; Spinal Cord; Tryptamines; Vasoconstriction | 2006 |
Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta.
Topics: Animals; Aorta, Thoracic; Atropine; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Lamiaceae; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Plant Extracts; Quinoxalines; Rats; Rats, Wistar; Triterpenes; Ursolic Acid; Vasodilation; Vasodilator Agents | 2006 |
Platelet aggregation profile as a marker of hydroxyurea bioavailability through nitric oxide generation in chronic myelogenous leukemia.
Topics: Adult; Biological Availability; Blood Platelets; Cyclic GMP; Enzyme Inhibitors; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Nitric Oxide; Oxadiazoles; Platelet Aggregation; Quinoxalines; Time Factors | 2006 |
Evidence for a role of inducible nitric oxide synthase in gastric relaxation of mdx mice.
Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Imines; Male; Mice; Mice, Inbred mdx; Muscle Relaxation; Muscle, Smooth; Muscular Dystrophy, Duchenne; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Receptors, Vasoactive Intestinal Peptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach; Vasoactive Intestinal Peptide | 2006 |
Nitric-oxide-dependent activation of pig oocytes: the role of the cGMP-signalling pathway.
Topics: Aminoquinolines; Animals; Cell Membrane Permeability; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Digitoxin; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase; Oocytes; Oxadiazoles; Penicillamine; Phosphoric Diester Hydrolases; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Swine | 2006 |
Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase.
Topics: Analysis of Variance; Blood Platelets; Carbon Monoxide; Collagen; Dose-Response Relationship, Drug; Guanylate Cyclase; Humans; Indazoles; Nitric Oxide Donors; Organometallic Compounds; Oxadiazoles; Penicillamine; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Spectrophotometry; Statistics, Nonparametric; Thrombin; Time Factors | 2006 |
Membrane potassium currents in human radial artery and their regulation by nitric oxide donor.
Topics: 4-Aminopyridine; Adult; Aged; Aged, 80 and over; Blotting, Western; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Ion Channel Gating; Male; Membrane Potentials; Middle Aged; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Penicillamine; Peptides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Quinoxalines; Radial Artery; Tetraethylammonium Compounds | 2006 |
P(2) purinoceptors account for the non-nitrergic NANC relaxation in the rat ileum.
Topics: Animals; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; Nitroprusside; Oxadiazoles; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P2; Tetrodotoxin | 2006 |
Involvement of nitric oxide-soluble guanylyl cyclase pathway in the control of maximal dentate gyrus activation in the rat.
Topics: Animals; Arginine; Dentate Gyrus; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Iontophoresis; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2006 |
Mechanisms of direct relaxant effect of sildenafil, tadalafil and vardenafil on corpus cavernosum.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calcium; Carbolines; Dose-Response Relationship, Drug; Imidazoles; Male; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Oxadiazoles; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Verapamil | 2006 |
Rat mesenteric arterial dilator response to 11,12-epoxyeicosatrienoic acid is mediated by activating heme oxygenase.
Topics: 8,11,14-Eicosatrienoic Acid; Acetylcholine; Animals; Carbon Monoxide; Dose-Response Relationship, Drug; Heme Oxygenase (Decyclizing); Male; Mesenteric Arteries; Mesoporphyrins; Organometallic Compounds; Oxadiazoles; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2006 |
Glutamatergic Control of Microvascular Tone by Distinct GABA Neurons in the Cerebellum.
Topics: Animals; Cerebellum; Cerebrovascular Circulation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Glutamic Acid; Hydrazines; In Vitro Techniques; Male; Microcirculation; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 2006 |
Nitric oxide mediates interactions between GABAA receptors and adenosine A1 receptors in the rat hippocampus.
Topics: 2-Chloroadenosine; Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; Guanylate Cyclase; Hippocampus; In Vitro Techniques; Male; Neural Inhibition; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptors, GABA-A; Synaptic Transmission | 2006 |
Endothelium-independent flow-induced dilation in the mouse carotid artery.
Topics: Acetylcholine; Animals; Blood Flow Velocity; Carotid Arteries; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Vasodilation; Vasodilator Agents | 2006 |
Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles.
Topics: Animals; Arterioles; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Kidney; Male; Mesoporphyrins; Microcirculation; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Renal Circulation; Soluble Guanylyl Cyclase; Vasoconstriction; Vasodilation | 2006 |
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.
Topics: Animals; Blood Pressure; Cyclic GMP; Deuteroporphyrins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heart Rate; Heme Oxygenase-1; Liver; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; Severity of Illness Index; Signal Transduction; Soluble Guanylyl Cyclase | 2006 |
Investigation of the mechanism for the relaxation of rat duodenum mediated via M1 muscarinic receptors.
Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Animals; Bicuculline; Dose-Response Relationship, Drug; Duodenum; Elapid Venoms; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Muscarinic Agonists; Muscarinic Antagonists; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Oxadiazoles; Penicillamine; Pirenzepine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Suramin | 2006 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
Anaphylactic shock depends on PI3K and eNOS-derived NO.
Topics: Anaphylaxis; Animals; Blood Pressure; Cardiovascular Diseases; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Phosphatidylinositol 3-Kinases; Platelet Activating Factor; Quinoxalines; Serum Albumin, Bovine; Transcription, Genetic | 2006 |
Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Biological Transport, Active; Calcium; Endothelins; Hormones; Immunohistochemistry; In Vitro Techniques; Kidney; Kidney Tubules; Microscopy, Confocal; Microscopy, Fluorescence; Nephrons; Oxadiazoles; Parathyroid Hormone-Related Protein; Perciformes; Quinoxalines | 2007 |
Histamine decreases myogenic tone in rat cerebral arteries by H2-receptor-mediated KV channel activation, independent of endothelium and cyclic AMP.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Benzenesulfonates; Calcium; Cerebral Arteries; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; Histamine Agonists; Histamine Antagonists; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Thiazoles; Vasoconstriction; Vasodilation | 2006 |
Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.
Topics: Animals; Benzofurans; Coronary Vessels; Cromakalim; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Ion Channel Gating; Membrane Potentials; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Receptors, Drug; Salvia miltiorrhiza; Swine | 2006 |
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Glyburide; Indoles; KATP Channels; Male; Neurons; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Pertussis Toxin; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tolbutamide | 2006 |
Cardiac mitochondrial cGMP stimulates cytochrome c release.
Topics: Animals; Apoptosis; Cells, Cultured; Cyclic GMP; Cytochromes c; Guanosine Triphosphate; Guanylate Cyclase; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar | 2007 |
Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitus.
Topics: Animals; Cellular Senescence; Cyclic GMP; Cytoplasmic Granules; Diabetes Mellitus; Female; Mice; Microtubules; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oocytes; Oxadiazoles; Oxyhemoglobins; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction; Zona Pellucida | 2006 |
Nitric oxide preconditioning regulates endothelial monolayer integrity via the heat shock protein 90-soluble guanylate cyclase pathway.
Topics: Actin Cytoskeleton; Animals; Aorta; Apoptosis; Cattle; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Impedance; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; HSP90 Heat-Shock Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spermine; Time Factors; Wound Healing | 2007 |
The suppressant effect of GEA3162 on spontaneous serotonin release from human colonic mucosa in vitro.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Colon; Electrochemistry; Enzyme Inhibitors; Gastrointestinal Hormones; Guanylate Cyclase; Hydroxyindoleacetic Acid; Intestinal Mucosa; Natriuretic Peptides; NG-Nitroarginine Methyl Ester; Nicardipine; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Serotonin; Triazoles | 2006 |
NANC inhibitory neuromuscular transmission in the hamster distal colon.
Topics: Adenosine Triphosphate; Animals; Apamin; Autonomic Nervous System; Colon; Cricetinae; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Male; Membrane Potentials; Mesocricetus; Muscle, Smooth; Neuroeffector Junction; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxadiazoles; Purinergic Antagonists; Quinoxalines; Receptors, Purinergic; Suramin; Synaptic Transmission; Thionucleotides; Triazines | 2006 |
Activation of nitric oxide signaling pathway mediates hypotensive effect of Muntingia calabura L. (Tiliaceae) leaf extract.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Injections, Intravenous; Magnoliopsida; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Plant Extracts; Plant Leaves; Plants, Medicinal; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tiliaceae; Water | 2006 |
Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent.
Topics: Adenosine; Adenosine Kinase; Animals; Cyclic GMP; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Hydrazines; Male; Nitric Oxide; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Thionucleotides; Xanthines | 2006 |
Nitric oxide directly inhibits ghrelin-activated neurons of the arcuate nucleus.
Topics: Action Potentials; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Ghrelin; Immunohistochemistry; Magnesium; Male; Neural Inhibition; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptide Hormones; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Thionucleotides | 2006 |
Prevention of pro-depressant effect of L-arginine in the forced swim test by NG-nitro-L-arginine and [1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one].
Topics: Animals; Antidepressive Agents; Arginine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Mice; Mice, Inbred BALB C; Motor Activity; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Swimming | 2007 |
Heme oxygenase-1 mediates cytoprotection against nitric oxide-induced cytotoxicity via the cGMP pathway in human pulp cells.
Topics: Blotting, Western; Cell Survival; Cells, Cultured; Cyclic GMP; Cytoprotection; Dental Pulp; Enzyme Induction; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase-1; Hemin; Humans; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxidative Stress; Penicillamine; Protoporphyrins; Quinoxalines | 2006 |
Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii.
Topics: Animals; Animals, Newborn; Diethylamines; Dose-Response Relationship, Drug; Electrochemistry; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Guanylate Cyclase; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neural Inhibition; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Presynaptic Terminals; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Solitary Nucleus; Synaptic Transmission; Time Factors | 2007 |
Dual mechanisms for nitric oxide control of large arteries in the estuarine crocodile Crocodylus porosus.
Topics: Acetylcholine; Alligators and Crocodiles; Animals; Aorta; Arteries; Blood Vessels; Endothelial Cells; Enzyme Inhibitors; Female; Male; NADPH Dehydrogenase; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Nitroarginine; Oxadiazoles; Quinoxalines; Vasodilation | 2007 |
The release of nitric oxide from S-nitrosothiols promotes angiogenesis.
Topics: Animals; Ascorbic Acid; Carbazoles; Cells, Cultured; Culture Media, Serum-Free; Cyclic GMP-Dependent Protein Kinases; Dithiothreitol; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroarginine; Ornithine; Oxadiazoles; Phosphorylation; Quinoxalines; S-Nitrosothiols; Swine | 2006 |
CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles.
Topics: Animals; Benzylamines; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indoles; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Phosphorylation; Potassium Channel Blockers; Pyloric Antrum; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Soluble Guanylyl Cyclase; Sulfonamides | 2007 |
The nitroxyl anion (HNO) is a potent dilator of rat coronary vasculature.
Topics: Acetylcholine; Animals; Anions; Antioxidants; Calcitonin Gene-Related Peptide; Coronary Vessels; Dose-Response Relationship, Drug; Guanylate Cyclase; Heart Rate; Isoproterenol; Male; Myocardial Contraction; Nifedipine; Nitrites; Nitrogen Oxides; Oxadiazoles; Oxidation-Reduction; Peptide Fragments; Perfusion; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Vasodilation | 2007 |
Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels.
Topics: 4-Aminopyridine; Animals; Aorta, Thoracic; Benzimidazoles; Calcium Channel Blockers; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Large-Conductance Calcium-Activated Potassium Channels; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Peptides; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Resveratrol; Stilbenes; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2007 |
Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury.
Topics: Aerosols; Animals; Blotting, Western; Bronchi; Bronchoalveolar Lavage Fluid; Cyclic GMP; Enzyme Inhibitors; Epithelial Cells; Guanylate Cyclase; Immunohistochemistry; Inflammation; Inhalation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Oxadiazoles; Protein Subunits; Quinoxalines; Respiratory Distress Syndrome; RNA, Messenger; Solubility; Tumor Necrosis Factor-alpha | 2007 |
Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Blotting, Western; Cell Adhesion Molecules; Cyclic GMP-Dependent Protein Kinases; Isometric Contraction; Luminescence; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Mitochondria, Muscle; Nitrates; Nitroglycerin; Nitroprusside; Oxadiazoles; Pentaerythritol Tetranitrate; Phosphoproteins; Quinoxalines; Structure-Activity Relationship; Vasodilator Agents | 2007 |
Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide.
Topics: Animals; Area Under Curve; Cerebellar Ataxia; Cerebellum; Chalcones; Cyclic GMP; Dronabinol; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitroprusside; Oxadiazoles; Postural Balance; Quinoxalines; Receptor, Cannabinoid, CB1; Receptors, Nicotinic; Stereotaxic Techniques | 2007 |
Nitroxyl anion donor, Angeli's salt, does not develop tolerance in rat isolated aortae.
Topics: Animals; Aorta, Thoracic; Benzoates; Cyclic GMP-Dependent Protein Kinases; Cysteine; Drug Tolerance; Enzyme Inhibitors; Free Radical Scavengers; Hydrazines; Imidazoles; In Vitro Techniques; Male; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitrogen Oxides; Nitroglycerin; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred WKY; Time Factors; Vasodilation | 2007 |
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines | 2007 |
Intrathecal cGMP elicits pressor responses and maintains mean blood pressure during haemorrhage in anaesthetized rats.
Topics: Anesthesia; Animals; Arginine; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Hemorrhage; Injections, Spinal; Nitric Oxide; Oxadiazoles; Pressoreceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Sympathetic Nervous System | 2007 |
Topical application of neuronal nitric oxide synthase inhibitor accelerates cutaneous barrier recovery and prevents epidermal hyperplasia induced by barrier disruption.
Topics: Administration, Topical; Animals; Calcium; Cell Membrane Permeability; Cells, Cultured; Enzyme Inhibitors; Homeostasis; Humans; Hyperplasia; Keratinocytes; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Oxadiazoles; Penicillamine; Quinoxalines; Skin | 2007 |
Modulation of inhibitory activity by nitric oxide in the thalamus.
Topics: Action Potentials; Anesthetics, Local; Animals; Animals, Newborn; Arginine; Drug Interactions; Enzyme Inhibitors; GABA Antagonists; Geniculate Bodies; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neural Inhibition; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Penicillamine; Pyridazines; Quinoxalines; Rats; Tetrodotoxin | 2007 |
Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Celecoxib; Coronary Vessels; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Guinea Pigs; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Perfusion; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Purinones; Pyrazoles; Quinoxalines; Rats; Regional Blood Flow; Signal Transduction; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents | 2007 |
Characterization of transcriptional regulation of neurogranin by nitric oxide and the role of neurogranin in SNP-induced cell death: implication of neurogranin in an increased neuronal susceptibility to oxidative stress.
Topics: Amino Acid Motifs; Animals; Apoptosis; Calcium; Calcium Signaling; Calmodulin; Cell Line; Cell Line, Tumor; Guanylate Cyclase; Homeostasis; Humans; Hypothalamus; Kidney; Mice; Mutagenesis, Site-Directed; Neuroblastoma; Neurogranin; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Oxidative Stress; Promoter Regions, Genetic; Protein Interaction Mapping; Quinoxalines; Recombinant Fusion Proteins; Transfection | 2007 |
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides | 2007 |
Role of NO/cGMP/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice.
Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Piperazines; Potassium Channels; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones; Zymosan | 2007 |
Vasorelaxant effects of icariin on isolated canine coronary artery.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Dinoprost; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Female; Flavonoids; Glyburide; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Oxytocics; Potassium Channel Blockers; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Vasodilation | 2007 |
Nitric oxide-mediated nonadrenergic noncholinergic relaxation of piglet pulmonary arteries decreases with postnatal age.
Topics: Animals; Animals, Newborn; Blotting, Western; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Mesenteric Arteries; Myography; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oxadiazoles; Pulmonary Artery; Quinoxalines; Swine; Tetrodotoxin; Vasodilation | 2007 |
Regulation of basolateral Cl(-) channels in airway epithelial cells: the role of nitric oxide.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amidines; Anions; Anthracenes; Benzylamines; Bestrophins; Cell Line; Cell Membrane; Cell Membrane Permeability; Cell Polarity; Chloride Channels; Cyclic GMP; Endothelial Cells; Epithelial Cells; Eye Proteins; Guanylate Cyclase; Humans; Ion Channel Gating; Lung; Macrophages, Alveolar; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Respiratory Mucosa | 2006 |
Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: correlated with NO-cGMP signaling pathway.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiovascular Agents; Cell Proliferation; Cell Size; Cells, Cultured; Cyclic GMP; Fibroblasts; Intracellular Space; L-Lactate Dehydrogenase; Male; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Resveratrol; Signal Transduction; Stilbenes | 2007 |
P2 purinoceptor antagonists inhibit the non-adrenergic, non-cholinergic relaxation of the human colon in vitro.
Topics: Adenosine Triphosphate; Colon, Sigmoid; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neurotransmitter Agents; Nitrergic Neurons; Nitric Acid; Nitric Oxide; Nitroarginine; Oxadiazoles; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinoxalines; Receptors, Purinergic P2; Statistics, Nonparametric; Suramin | 2007 |
Membrane potential gradient is carbon monoxide-dependent in mouse and human small intestine.
Topics: Animals; Carbon Monoxide; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Humans; In Vitro Techniques; Intestine, Small; Membrane Potentials; Mesoporphyrins; Mice; Mice, Knockout; Mice, Neurologic Mutants; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tetrodotoxin | 2007 |
Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Heart; Heart Atria; Hypertension; Male; Myocardium; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroprusside; Norepinephrine; Oxadiazoles; Promoter Regions, Genetic; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Substrate Specificity; Sympathetic Nervous System; Synaptic Transmission | 2007 |
Mechanisms of relaxing response induced by rat/mouse hemokinin-1 in porcine coronary arteries: roles of potassium ion and nitric oxide.
Topics: Animals; Anti-Infective Agents, Local; Clotrimazole; Coronary Vessels; Dequalinium; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Mice; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperidines; Potassium; Potassium Channel Blockers; Protein Precursors; Quinoxalines; Quinuclidines; Rats; Receptors, Neurokinin-1; Receptors, Prostaglandin; Substance P; Swine; Tachykinins; Tetraethylammonium; Vasodilation | 2007 |
NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes.
Topics: Animals; Cells, Cultured; Chlorides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Flavonoids; Guanylate Cyclase; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Heart; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxazines; Oxidation-Reduction; Penicillamine; Phosphorylation; Quinoxalines; Rats; Signal Transduction; Zinc; Zinc Compounds | 2007 |
In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Brazil; Coumarins; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Glyburide; In Vitro Techniques; Male; Mice; Mikania; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Oxadiazoles; Plant Extracts; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Toxicity Tests, Acute; Toxicity Tests, Chronic; Trachea | 2007 |
Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Topics: Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indazoles; Kidney Transplantation; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Organ Preservation; Oxadiazoles; Platelet Aggregation Inhibitors; Quinoxalines; Retrospective Studies; Vasodilation; Vasodilator Agents | 2007 |
Modulation of gap-junction-dependent arterial relaxation by ascorbic acid.
Topics: Animals; Ascorbic Acid; Boron Compounds; Connexin 43; Connexins; Dose-Response Relationship, Drug; Endothelium, Vascular; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Gap Junctions; Hydrazines; Iliac Artery; Indoles; Indomethacin; Male; Membrane Potentials; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rabbits; Vasodilation | 2007 |
Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice.
Topics: Animals; Arginine; Behavior, Animal; Catalepsy; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Injections, Intraventricular; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors | 2007 |
N(G)-nitro-L-arginine methyl ester, but not methylene blue, attenuates anaphylactic hypotension in anesthetized mice.
Topics: Anaphylaxis; Anesthesia; Animals; Blood Pressure; Enzyme Inhibitors; Guanylate Cyclase; Hypertension; Liver Circulation; Male; Methylene Blue; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Ovalbumin; Oxadiazoles; Quinoxalines | 2007 |
Nitric oxide modulates ionic transport in the isolated intestine of the eel, Anguilla anguilla.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Anguilla; Animals; Arginine; Bicarbonates; Chlorides; Cyclic GMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Permeability; Quinoxalines; Time Factors | 2007 |
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents | 2007 |
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation | 2007 |
Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway.
Topics: Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Focal Adhesion Kinase 2; Guanylate Cyclase; Hypertrophy; Leucine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphorylation; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Soluble Guanylyl Cyclase | 2007 |
Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase.
Topics: Actins; Benzamides; Benzoates; Blotting, Western; Cell Differentiation; Cells, Cultured; Cyclic GMP; Dinoprostone; Drug Synergism; Enzyme Activators; Fibroblasts; Fibrosis; Guanylate Cyclase; Humans; Immunohistochemistry; Isoenzymes; Lung; Myocytes, Smooth Muscle; Natriuretic Peptide, Brain; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Transforming Growth Factor beta | 2007 |
Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus.
Topics: Analysis of Variance; Animals; Anxiety; Cyclic GMP; Dentate Gyrus; Dose-Response Relationship, Drug; Guanylate Cyclase; Hippocampus; Indazoles; Male; Maze Learning; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Punishment; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2007 |
Resveratrol, a component of red wine, elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and potassium channels.
Topics: Animals; Antioxidants; Arterioles; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Flavonoids; Guanylate Cyclase; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Resveratrol; Retinal Artery; Stilbenes; Swine; Vasodilation; Vasodilator Agents; Video Recording; Wine | 2007 |
Interaction between glutamatergic and nitrergic mechanisms mediating cardiovascular responses to L-glutamate injection in the diagonal band of Broca in anesthetized rats.
Topics: Anesthesia; Animals; Arginine; Benzoates; Blood Pressure; Diagonal Band of Broca; Dose-Response Relationship, Drug; Glutamic Acid; Heart Rate; Imidazoles; Isoquinolines; Male; Microinjections; Nitrergic Neurons; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate | 2007 |
Lipopolysaccharide induces early tolerance to excitotoxicity via nitric oxide and cGMP.
Topics: Animals; Anisomycin; Brain Diseases; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Ischemic Preconditioning; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Protein Synthesis Inhibitors; Quinoxalines | 2007 |
Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.
Topics: Administration, Inhalation; Aerosols; Animals; Benzoates; Cyclic GMP; Dose-Response Relationship, Drug; Drug Combinations; Guanylate Cyclase; Injections, Intravenous; Lung; Morpholines; Nitric Oxide; Oxadiazoles; Particle Size; Phosphodiesterase Inhibitors; Powders; Pulmonary Circulation; Purinones; Pyrazoles; Pyridines; Pyrimidines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vasodilation | 2007 |
Characterization of the non-adrenergic/non-cholinergic response to perivascular nerve stimulation in the double-perfused mesenteric bed of the mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Endothelium, Vascular; Female; Male; Mesenteric Arteries; Mesenteric Veins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Culture Techniques; Oxadiazoles; Perfusion; Peripheral Nerves; Potassium Chloride; Quinoxalines; Splanchnic Circulation | 2007 |
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Charybdotoxin; Cholesterol; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hypercholesterolemia; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Oxidative Stress; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Vasodilation; Vasodilator Agents | 2008 |
Sulphonylureas induced vasorelaxation of mouse arteries.
Topics: Adamantane; Animals; Arteries; Endothelium, Vascular; Glyburide; In Vitro Techniques; KATP Channels; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Morpholines; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Quinoxalines; Sulfonylurea Compounds; Vascular Resistance; Vasoconstrictor Agents | 2007 |
Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.
Topics: Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hyperalgesia; Male; Masseter Muscle; Methylene Blue; Mice; Nerve Tissue Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Sensory Thresholds; Soluble Guanylyl Cyclase; Time Factors; Trigeminal Caudal Nucleus | 2007 |
Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis.
Topics: Animals; Colitis; Cyclic GMP; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Guanylate Cyclase; Inflammation; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Soluble Guanylyl Cyclase | 2008 |
Endothelial nitric oxide has inhibitory effects on rhythmic contractions in the aortas of sinoaortic deafferented rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Autonomic Denervation; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Phenylephrine; Quinoxalines; Rats | 2007 |
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats.
Topics: Action Potentials; Anesthesia; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic GMP-Dependent Protein Kinases; Electromyography; Enzyme Inhibitors; Hyperalgesia; Neuronal Plasticity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Reflex; Signal Transduction; Spinal Cord | 2008 |
Peroxynitrite inhibits the expression of G(i)alpha protein and adenylyl cyclase signaling in vascular smooth muscle cells.
Topics: Adenylyl Cyclase Inhibitors; Animals; Aorta, Thoracic; Blotting, Western; Carbazoles; Cells, Cultured; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Indoles; Mitogen-Activated Protein Kinases; Muscle Relaxation; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxadiazoles; Peroxynitrous Acid; Quinoxalines; Rats; Receptor, Angiotensin, Type 1; Receptors, Atrial Natriuretic Factor; Signal Transduction | 2008 |
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginase; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin-1; Indomethacin; Lung Diseases; Male; Models, Biological; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasoconstriction | 2008 |
Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.
Topics: Animals; Arginine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Diazoxide; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Glutathione; Glyburide; Guanylate Cyclase; Hemoglobins; KATP Channels; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peptic Ulcer Hemorrhage; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sildenafil Citrate; Stomach Ulcer; Sulfones | 2008 |
Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Biotin; Coronary Vessels; Genetic Predisposition to Disease; Glucose Tolerance Test; Guanylate Cyclase; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Time; Vitamins | 2008 |
Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diazoxide; Dose-Response Relationship, Drug; Guanylate Cyclase; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Membrane Potentials; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Triazenes; Uncoupling Agents | 2008 |
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Free Radical Scavengers; Guanylate Cyclase; Humans; Hydrogen Peroxide; Hydroquinones; In Vitro Techniques; Indomethacin; Mannitol; Mesenteric Artery, Superior; Methylene Blue; Muramidase; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Prostaglandins; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sepsis; Signal Transduction; Soluble Guanylyl Cyclase; Thionucleotides; Time Factors; Vasoconstrictor Agents; Vasodilation | 2008 |
Intrathecally injected morphine inhibits inflammatory paw edema: the involvement of nitric oxide and cyclic-guanosine monophosphate.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Guanylate Cyclase; Inflammation; Injections, Spinal; Male; Morphine; Naloxone; Narcotic Antagonists; Neutrophil Infiltration; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Peroxidase; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Sildenafil Citrate; Spinal Cord; Sulfones; Time Factors | 2008 |
Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation.
Topics: Adult; alpha-Thalassemia; Anemia, Sickle Cell; CD11a Antigen; CD11b Antigen; Cell Adhesion; Cyclic GMP; Endothelial Cells; Female; Fibronectins; Humans; Hydrazines; Hydroxyurea; Integrin alpha4; Intercellular Adhesion Molecule-1; Male; Middle Aged; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sickle Cell Trait | 2008 |
Vardenafil protects isolated rat hearts at reperfusion dependent on GC and PKG.
Topics: Animals; Calcium; Carbazoles; Cell Adhesion Molecules; Cell Death; Cell Line; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; In Vitro Techniques; Microfilament Proteins; Mitochondria, Heart; Mitochondrial Membranes; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoproteins; Piperazines; Quinoxalines; Rats; Sulfones; Triazines; Vardenafil Dihydrochloride | 2008 |
Nitric oxide regulates steroid synthesis by bovine antral granulosa cells in a chemically defined medium.
Topics: Animals; Cattle; Cell Cycle; Cell Survival; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Female; Granulosa Cells; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Progesterone; Quinoxalines | 2009 |
Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity.
Topics: Alternative Splicing; Animals; Catalytic Domain; Cell Line, Tumor; Enzyme Inhibitors; Guanylate Cyclase; Humans; Organ Specificity; Oxadiazoles; Protein Isoforms; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spodoptera | 2008 |
NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Animals; Aqueous Humor; Cell Line; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Intraocular Pressure; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Microscopy, Confocal; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Osmolar Concentration; Oxadiazoles; Peptides; Perfusion; Potassium Channel Blockers; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Thionucleotides; Time Factors; Tissue Culture Techniques; Trabecular Meshwork | 2008 |
Two autocrine pathways to regulate cyclic GMP synthesis in cultured human retinal pigment epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Autocrine Communication; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Guanylate Cyclase; Humans; Immunohistochemistry; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Oxadiazoles; Phosphodiesterase Inhibitors; Pigment Epithelium of Eye; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.
Topics: Animals; Calcium-Binding Proteins; Cardiotonic Agents; Cattle; Chromogranin A; Depression, Chemical; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nitric Oxide Synthase; Oligopeptides; omega-N-Methylarginine; Oxadiazoles; Peptide Fragments; Phosphorylation; Piperidines; Quinoxalines; Rana esculenta; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Stroke Volume | 2008 |
Endothelial nitric oxide attenuates Na+/Ca2+ exchanger-mediated vasoconstriction in rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta, Thoracic; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Potassium; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Thiourea; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
The reduction of arterial tension produced by stevioside is dependent on nitric oxide synthase activity when the endothelium is intact.
Topics: Animals; Aorta, Thoracic; Diterpenes, Kaurane; Endothelium, Vascular; Enzyme Inhibitors; Glucosides; Guanylate Cyclase; In Vitro Techniques; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Sweetening Agents; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2008 |
Heme proteins mediate the conversion of nitrite to nitric oxide in the vascular wall.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Dose-Response Relationship, Drug; Electrochemistry; Electron Spin Resonance Spectroscopy; Endothelium-Dependent Relaxing Factors; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Hemeproteins; In Vitro Techniques; Infusions, Intravenous; Male; Nitric Oxide; Nitrites; Oxadiazoles; Oxyhemoglobins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Vasodilation | 2008 |
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
Topics: Animals; Apamin; Blotting, Western; Colon; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanylate Cyclase; Male; Mice; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neural Inhibition; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Potassium Channel Blockers; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Small-Conductance Calcium-Activated Potassium Channels; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide | 2008 |
Tanshinone IIA: a new activator of human cardiac KCNQ1/KCNE1 (I(Ks)) potassium channels.
Topics: Abietanes; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guanylate Cyclase; Heart; Humans; KCNQ1 Potassium Channel; Kv1.5 Potassium Channel; Nitric Oxide Donors; Oxadiazoles; Phenanthrenes; Potassium Channels, Voltage-Gated; Quinoxalines | 2008 |
Nitric oxide mediates stretch-induced Ca2+ release via activation of phosphatidylinositol 3-kinase-Akt pathway in smooth muscle.
Topics: Androstadienes; Animals; Calcium; Enzyme Activation; Enzyme Inhibitors; Mice; Mice, Knockout; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Urothelium; Wortmannin | 2008 |
Pyritinol reduces nociception and oxidative stress in diabetic rats.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Female; Indomethacin; Naltrexone; Oxadiazoles; Oxidative Stress; Pyrithioxin; Quinoxalines; Rats; Rats, Wistar; Streptozocin | 2008 |
Interstitial cells of Cajal in the urethra are cGMP-mediated targets of nitrergic neurotransmission.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cyclic GMP; Enteric Nervous System; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Proto-Oncogene Proteins c-kit; Quinoxalines; Rats; Sheep; Synaptic Transmission; Ubiquitin Thiolesterase; Urethra; Vimentin | 2008 |
Calcitonin gene-related peptide suppresses pacemaker currents by nitric oxide/cGMP-dependent activation of ATP-sensitive K(+) channels in cultured interstitial cells of Cajal from the mouse small intestine.
Topics: Adenine; Animals; Calcitonin Gene-Related Peptide; Cells, Cultured; Cyclic GMP; Female; Guanylate Cyclase; Intestine, Small; KATP Channels; Male; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Quinoxalines | 2008 |
Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2.
Topics: Adenocarcinoma; Blotting, Western; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Fluorescent Antibody Technique; Grape Seed Extract; Guanylate Cyclase; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Plant Extracts; Proanthocyanidins; Quinoxalines; Receptors, Cell Surface; Signal Transduction; Tumor Cells, Cultured; Vitis | 2009 |
Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions.
Topics: Adrenergic Antagonists; Animals; Colforsin; Cyclic AMP; Guanylate Cyclase; Heart; Indoles; Isoproterenol; Male; Maleimides; Melatonin; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Propranolol; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2008 |
Pre-conditioning induced by carbon monoxide provides neuronal protection against apoptosis.
Topics: Animals; Animals, Newborn; Apoptosis; Carbon Monoxide; Cells, Cultured; Cerebellum; Decanoic Acids; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Hydroxy Acids; Metalloporphyrins; Mice; Neurons; NG-Nitroarginine Methyl Ester; Oxadiazoles; Oxidative Stress; Quinoxalines; Reactive Oxygen Species; tert-Butylhydroperoxide; Time Factors | 2008 |
EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase.
Topics: Animals; Anticarcinogenic Agents; Carcinoma; Catechin; Cell Line, Tumor; Cell Movement; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Mammary Neoplasms, Animal; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrogen Oxides; Oxadiazoles; Quinoxalines | 2008 |
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one inhibits neurite outgrowth and causes neurite retraction in PC12 cells independently of soluble guanylyl cyclase.
Topics: Animals; Cell Line; Enzyme Inhibitors; Guanylate Cyclase; Humans; Nerve Growth Factor; Neurites; Oxadiazoles; PC12 Cells; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2009 |
Fluvastatin reduces pulmonary vein spontaneous activity through nitric oxide pathway.
Topics: Action Potentials; Androstadienes; Animals; Atrial Fibrillation; Blotting, Western; Electrophysiology; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Heart Atria; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Indoles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Oncogene Protein v-akt; Oxadiazoles; Phosphatidylinositol 3-Kinases; Pulmonary Veins; Quinoxalines; Rabbits; Signal Transduction; Wortmannin | 2009 |
Characterization of NO-sensitive guanylyl cyclase: expression in an identified interneuron involved in NO-cGMP-dependent memory formation.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Cyclic GMP; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Insect Proteins; Interneurons; Lymnaea; Memory; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sequence Alignment; Soluble Guanylyl Cyclase | 2008 |
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dopamine; Drug Interactions; Enzyme Inhibitors; Indomethacin; Interleukin-1beta; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar; Sensory Receptor Cells; Signal Transduction | 2008 |
Inhibition by lithium of the nitrergic relaxation of rat anococcygeus muscle.
Topics: Analysis of Variance; Animals; Arginine; Electric Stimulation; Lithium Chloride; Male; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Sodium azide induced neuronal damage in vitro: evidence for non-apoptotic cell death.
Topics: Acetylcarnitine; Animals; Antioxidants; Apoptosis; Cell Death; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromans; Dizocilpine Maleate; Guanylate Cyclase; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Azide | 2009 |
cGMP-independent anti-apoptotic effect of nitric oxide on thapsigargin-induced apoptosis in the pancreatic beta-cell line INS-1.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Flow Cytometry; Insulin-Secreting Cells; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Thapsigargin; Triazenes | 2008 |
Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Animals; Antibodies, Bacterial; Benzoates; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; Immunity, Cellular; Immunization; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lipopolysaccharides; Lysine; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Skin Diseases, Bacterial; Spleen; Th1 Cells | 2009 |
Effect of the phosphodiesterase 5 inhibitors sildenafil, tadalafil and vardenafil on rat anococcygeus muscle: functional and biochemical aspects.
Topics: Animals; Carbolines; Drug Evaluation, Preclinical; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitroglycerin; Oxadiazoles; Penile Erection; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents | 2009 |
Signal transduction pathways and haem oxygenase induction in soybean leaves subjected to salt stress.
Topics: Blotting, Western; Enzyme Activation; Glutathione; Glycine max; Heme Oxygenase (Decyclizing); Hydrogen Peroxide; Lanthanum; Onium Compounds; Oxadiazoles; Oxidative Stress; Plant Leaves; Plant Proteins; Quinoxalines; Signal Transduction; Sodium Chloride; Thiobarbituric Acid Reactive Substances | 2008 |
Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cecum; Cyclic GMP; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Female; Guanylate Cyclase; Methylene Blue; Mortality; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; RNA, Messenger; Sepsis; Vasoconstriction | 2009 |
Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork.
Topics: Adult; Aged, 80 and over; Animals; Aqueous Humor; Blotting, Western; Cell Culture Techniques; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; Isoenzymes; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Trabecular Meshwork; Triazenes | 2009 |
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.
Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Oxadiazoles; Penis; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rabbits; Stephania tetrandra; Tetraethylammonium | 2009 |
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork | 2009 |
Epigallocatechin-3-gallate relaxes the isolated bovine ophthalmic artery: involvement of phosphoinositide 3-kinase-Akt-nitric oxide/cGMP signalling pathway.
Topics: Androstadienes; Animals; Catechin; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Ophthalmic Artery; Oxadiazoles; Penicillamine; Peptides; Phosphatidylinositols; Proto-Oncogene Proteins c-akt; Quinoxalines; Serotonin; Signal Transduction; Vasodilation; Wortmannin | 2009 |
Nitric oxide attenuates the expression of natriuretic peptide receptor C and associated adenylyl cyclase signaling in aortic vascular smooth muscle cells: role of MAPK.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta; Carbazoles; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; GTP-Binding Protein alpha Subunits, Gi-Go; MAP Kinase Signaling System; Metalloporphyrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phosphorylation; Protein Kinase Inhibitors; Quinoxalines; Rats; Receptors, Atrial Natriuretic Factor; S-Nitroso-N-Acetylpenicillamine | 2009 |
Redox variants of NO (NO{middle dot} and HNO) elicit vasorelaxation of resistance arteries via distinct mechanisms.
Topics: 4-Aminopyridine; Animals; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitrogen Oxides; Oxadiazoles; Oxidation-Reduction; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vascular Resistance; Vasodilation; Vasodilator Agents | 2009 |
N-acetylcysteine-induced vasodilation involves voltage-gated potassium channels in rat aorta.
Topics: Acetylcysteine; Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Guanylate Cyclase; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Vasoconstrictor Agents; Vasodilation | 2009 |
Evidence of a Ca(2+)-(*)NO-cGMP signaling pathway controlling zoospore biogenesis in the aquatic fungus Blastocladiella emersonii.
Topics: Amino Acid Sequence; Blastocladiella; Calcium; Cyclic GMP; Cytosol; Enzyme Activators; Enzyme Inhibitors; Expressed Sequence Tags; Fungal Proteins; Gene Expression Profiling; Guanylate Cyclase; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Sequence Alignment; Signal Transduction; Spores, Fungal | 2009 |
Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries.
Topics: Altitude Sickness; Animals; Cerebral Arteries; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Enzyme Inhibitors; Female; Fetus; Guanylate Cyclase; Hypoxia; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Pregnancy; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vasodilation | 2009 |
NOC-9, a selective nitric oxide donor, induces flight reactions in the dorsolateral periaqueductal gray of rats by activating soluble guanylate cyclase.
Topics: Animals; Catheterization; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escape Reaction; Guanylate Cyclase; Male; Microinjections; Molsidomine; Motor Activity; Multivariate Analysis; Nitric Oxide Donors; Oxadiazoles; Periaqueductal Gray; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Time Factors; Triazenes | 2009 |
Endothelium-derived nitric oxide contributes to the vasorelaxant response induced by mesoionic 2-(4-chlorophenyl)-3-methyl-4-(4-methoxyphenyl)-1;3-thiazolium-5-thyolate (CMMTT) in rats.
Topics: Animals; Biological Factors; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Thiazoles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2009 |
Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
Topics: Acetylcholine; Animals; Animals, Newborn; Benzoates; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fetus; Gestational Age; Guanylate Cyclase; Hypertension, Pulmonary; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Pulmonary Wedge Pressure; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2009 |
Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.
Topics: Aequorin; Animals; Benzoates; Binding Sites; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Cyclic Nucleotide-Gated Cation Channels; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Enzyme Stability; Genes, Reporter; Guanylate Cyclase; Heme; Molecular Structure; Mutation; ortho-Aminobenzoates; Oxadiazoles; Oxidation-Reduction; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Structure-Activity Relationship; Sulfonamides; Swine; Transfection | 2009 |
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Topics: Analysis of Variance; Animals; Back; CD47 Antigen; Cyclic GMP; Enzyme Inhibitors; Gene Silencing; Ischemia; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Nitric Oxide; Nitrites; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Surgical Flaps; Thrombospondin 1; Xanthine Dehydrogenase | 2009 |
Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia.
Topics: Analgesics; Animals; Arginine; Cyclic GMP; Down-Regulation; Female; Gonadal Hormones; Humans; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sex Characteristics; Signal Transduction; Temporomandibular Joint; Trigeminal Ganglion | 2009 |
Selective inhibition of guanylate cyclase prevents impairment of hypoxic pulmonary vasoconstriction in endotoxemic mice.
Topics: Animals; Dose-Response Relationship, Drug; Endotoxemia; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Pulmonary Circulation; Quinoxalines; Vasoconstriction | 2009 |
Nitric oxide modulation of methylphenidate-induced disruption of prepulse inhibition in Swiss mice.
Topics: Animals; Auditory Perception; Clozapine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; GABA Antagonists; Haloperidol; Indazoles; Male; Methylphenidate; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Reflex, Startle | 2009 |
Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia.
Topics: Animals; Apoptosis; Cell Death; Cell Line; Cell Membrane; Cell Nucleus; Cells, Cultured; Chromatin; Cyclic GMP; Enzyme Inhibitors; Intracellular Space; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Nitrites; Oxadiazoles; Phosphatidylserines; Quaternary Ammonium Compounds; Quinoxalines | 2009 |
Anxiolytic effects of phosphodiesterase-2 inhibitors associated with increased cGMP signaling.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cells, Cultured; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Exonucleases; Guanylate Cyclase; Imidazoles; Male; Mice; Mice, Inbred ICR; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Quinoxalines; Rats; Recombinant Proteins; Signal Transduction; Triazines | 2009 |
Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Amides; Constriction, Pathologic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nitroarginine; Nitroprusside; Oxadiazoles; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Radial Artery; Receptors, Calcium-Sensing; rho-Associated Kinases; Vasoconstriction; Vasodilation | 2009 |
Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis.
Topics: Albumins; Animals; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Feedback, Physiological; Female; Glomerular Filtration Rate; Hydrostatic Pressure; Hypertension, Renal; Kidney; Natriuresis; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Circulation; Urine | 2009 |
Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation.
Topics: Blood Platelets; Blood Proteins; Collagen; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Humans; Immunoblotting; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Function Tests; Quinoxalines; S-Nitrosoglutathione; Signal Transduction | 2009 |
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; ADP-ribosyl Cyclase; Animals; Arterioles; Calcium; Calcium Signaling; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley | 2010 |
A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and N(G)-nitro-l-arginine hypertensive r
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels, L-Type; Desoxycorticosterone; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypertension; Indomethacin; Male; Nitroarginine; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2010 |
The effect of heme oxygenase inhibition on visual evoked potentials.
Topics: Animals; Arsenites; Enzyme Activators; Enzyme Induction; Enzyme Inhibitors; Evoked Potentials, Visual; Heme Oxygenase (Decyclizing); Indazoles; Male; Metalloporphyrins; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Compounds; Visual Pathways | 2009 |
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction | 2010 |
Nitric oxide-soluble guanylyl cyclase signaling regulates corticostriatal transmission and short-term synaptic plasticity of striatal projection neurons recorded in vivo.
Topics: Action Potentials; Analysis of Variance; Animals; Biophysics; Corpus Striatum; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Frontal Lobe; Guanylate Cyclase; Indazoles; Male; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Neurons; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Synaptic Transmission; Time Factors | 2010 |
Nitric oxide stimulates interleukin-6 production in skeletal myotubes.
Topics: Animals; Cell Line; Cyclic GMP; Flavonoids; Imidazoles; Immunization; Interleukin-6; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Muscle Fibers, Skeletal; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Quinoxalines; Up-Regulation | 2010 |
Synergistic effect of [1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one] and antidepressant drugs in the mouse forced swimming test: possible involvement of serotonergic pathway.
Topics: Animals; Antidepressive Agents; Drug Synergism; Male; Mice; Mice, Inbred BALB C; Oxadiazoles; Quinoxalines; Serotonin; Swimming; Time Factors | 2010 |
Protein kinase G type-Ialpha phosphorylates the apoptosis-regulating protein Bad at serine 155 and protects against apoptosis in N1E-115 cells.
Topics: Apoptosis; bcl-Associated Death Protein; Blotting, Western; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; DNA Fragmentation; Enzyme Activation; Humans; Nitric Oxide; Oxadiazoles; Phosphorylation; Quinoxalines; Recombinant Proteins; Serine | 2010 |
C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Umbilical Cord | 2010 |
Serotonin modulates glutamatergic transmission in the rat olfactory tubercle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Citalopram; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Male; Olfactory Pathways; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists; Synaptic Transmission; Tryptamines | 2010 |
Properties of Rikkunshi-to (TJ-43)-induced relaxation of rat gastric fundus smooth muscles.
Topics: Animals; Apamin; Drugs, Chinese Herbal; Enprostil; Gastric Fundus; Hesperidin; Membrane Potentials; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Potassium; Pyrimidinones; Quinoxalines; Rats; Thiazoles; Verapamil | 2010 |
Propyretic role of the locus coeruleus nitric oxide pathway.
Topics: Animals; Cyclic GMP; Endotoxins; Fever; Guanylate Cyclase; Locus Coeruleus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2010 |
Cyclic GMP as a second messenger in the nitric oxide-mediated conidiation of the mycoparasite Coniothyrium minitans.
Topics: Arginine; Ascomycota; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Second Messenger Systems; Spores, Fungal | 2010 |
Water extract of Zanthoxylum piperitum induces vascular relaxation via endothelium-dependent NO-cGMP signaling.
Topics: Androstadienes; Animals; Boron Compounds; Calcium; Calcium Channels; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Gadolinium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Plant Extracts; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thapsigargin; Vasoconstriction; Vasodilator Agents; Wortmannin; Zanthoxylum | 2010 |
Differential regulation of vasoactive intestinal peptide (VIP) in the dentate gyrus and hippocampus via the NO-cGMP pathway following kainic acid-induced seizure in the rat.
Topics: Animals; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Hippocampus; Indazoles; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide | 2010 |
Nitric oxide and downstream second messenger cGMP and cAMP enhance adipogenesis in primary human preadipocytes.
Topics: Adenylyl Cyclase Inhibitors; Adipocytes; Adipogenesis; Adult; Cell Proliferation; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; DDT; Guanylate Cyclase; Humans; Male; Middle Aged; Nitric Oxide; Oxadiazoles; Quinoxalines; Second Messenger Systems; Stem Cells; Subcutaneous Fat; Tissue Engineering | 2010 |
Nia1 and Nia2 are involved in exogenous salicylic acid-induced nitric oxide generation and stomatal closure in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cyclic ADP-Ribose; Cyclic GMP; Mutation; Niacinamide; Nitrate Reductase; Nitric Oxide; Nitroprusside; Oxadiazoles; Plant Stomata; Protein Kinase Inhibitors; Protein Kinases; Quinoxalines; Salicylic Acid; Signal Transduction | 2010 |
Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Lung; Myosin-Light-Chain Phosphatase; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Protein Isoforms; Protein Phosphatase 1; Pulmonary Artery; Quinoxalines; Swine; Triazenes; Vasoconstrictor Agents | 2010 |
Differential involvement of 5-HT(1A) and 5-HT(1B/1D) receptors in human interferon-alpha-induced immobility in the mouse forced swimming test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Depression; Fluoxetine; Interferon-alpha; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming | 2010 |
A soluble guanylate cyclase mediates negative signaling by ammonium on expression of nitrate reductase in Chlamydomonas.
Topics: Aminoquinolines; Arabidopsis; Arabidopsis Proteins; Calcium; Chlamydomonas reinhardtii; Cyclic GMP; Cyclic N-Oxides; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Imidazoles; Models, Biological; Molecular Sequence Data; Mutation; NG-Nitroarginine Methyl Ester; Nitrate Reductase; Nitric Oxide; Nitrogen; Oxadiazoles; Quaternary Ammonium Compounds; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Transcription, Genetic | 2010 |
Cardiovascular responses to L-glutamate microinjection into the hypothalamic paraventricular nucleus are mediated by a local nitric oxide-guanylate cyclase mechanism.
Topics: Animals; Benzoates; Blood Pressure; Cardiovascular System; Drug Interactions; Glutamic Acid; Guanylate Cyclase; Heart Rate; Imidazoles; Male; Microinjections; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Time Factors; Wakefulness | 2010 |
Comparison of vasorelaxant effect and tolerance profile of a novel isosorbide-5-mononitrate derivative with its stereoisomer and parent drug on rat mesenteric artery.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electrophoresis, Capillary; Endothelium, Vascular; In Vitro Techniques; Isosorbide Dinitrate; Magnetic Resonance Spectroscopy; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Spectrophotometry, Infrared; Stereoisomerism; Vasoconstrictor Agents; Vasodilator Agents | 2010 |
Carbon monoxide and nitric oxide modulate hyperosmolality-induced oxytocin secretion by the hypothalamus in vitro.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Carbon Monoxide; Enzyme Inhibitors; Hypothalamus; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroprusside; Osmotic Pressure; Oxadiazoles; Oxytocin; Quinoxalines; Rats; Rats, Wistar | 2010 |
Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Glucocorticoids; Guanylate Cyclase; Hydrazines; Hydrocortisone; Injections, Intraperitoneal; Lipopolysaccharides; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Ovalbumin; Oxadiazoles; Pneumonia; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Respiration, Artificial; Respiratory Mechanics; Soluble Guanylyl Cyclase | 2010 |
Effects induced by inhibitors of the phosphatidylinositol 3-kinase/Akt and nitric oxide synthase/guanylyl cyclase pathways on the isometric contraction in rat aorta: a comparative study.
Topics: Androstadienes; Angiotensin II; Animals; Aorta, Thoracic; Chromones; Endothelium, Vascular; Guanylate Cyclase; Isometric Contraction; Male; Morpholines; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Phenylephrine; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Potassium; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Signal Transduction; Wortmannin | 2011 |
Role of central NO-cGMP pathway in vasopressin and oxytocin gene expression during sepsis.
Topics: Animals; Arginine Vasopressin; Cyclic GMP; Enzyme Inhibitors; Gene Expression Regulation; Male; Nitric Oxide; Oxadiazoles; Oxytocin; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Sepsis; Signal Transduction; Supraoptic Nucleus | 2010 |
Agonist-specific compartmentation of cGMP action in myometrium.
Topics: Animals; Blotting, Western; Caveolin 1; Cell Membrane; Cyclic GMP; Enzyme Inhibitors; Estrogens; Female; Glycolipids; Guanylate Cyclase; Guinea Pigs; Humans; Myometrium; Natriuretic Peptides; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pregnancy; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Trachea | 2010 |
Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sheep; Sphincter of Oddi; Triazenes | 2010 |
Nitric oxide in the control of luminescence from lantern shark (Etmopterus spinax) photophores.
Topics: Animal Structures; Animals; Cyclic GMP; Embryo, Nonmammalian; Enzyme Inhibitors; Guanylate Cyclase; Hydroxylamine; Immunohistochemistry; Luminescence; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Sharks; Signal Transduction; Spectrum Analysis | 2010 |
Superoxide differentially controls pulmonary and systemic vascular tone through multiple signalling pathways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Aminoquinolines; Animals; Calcium Signaling; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Myocytes, Smooth Muscle; Oxadiazoles; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; rho-Associated Kinases; Superoxides; Vasoconstriction; Vasoconstrictor Agents | 2011 |
Inhibition of hypoxic pulmonary vasoconstriction of rats by carbon monoxide.
Topics: Animals; Carbon Monoxide; Guanylate Cyclase; Hypoxia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Tetraethylammonium; Vasoconstriction | 2010 |
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling | 2011 |
Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Blood Pressure; Cyclic GMP; Dimethyl Sulfoxide; Heart Rate; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism; Sympathetic Nervous System | 2011 |
Nitrergic inhibition of tachykininergic neuro-muscular transmission via cyclic GMP in the hamster ileum.
Topics: Animals; Cricetinae; Cyclic GMP; Ileum; Male; Membrane Potentials; Mesocricetus; Myocytes, Smooth Muscle; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Substance P; Tachykinins | 2011 |
Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.
Topics: Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcitonin Receptor-Like Protein; Carbon Tetrachloride; Cyclic GMP; Electric Stimulation; Glyburide; KATP Channels; Liver Cirrhosis; Male; Mesenteric Arteries; Muscle Cells; Oxadiazoles; Peptide Fragments; Pinacidil; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Sulfonylurea Receptors; Vasoconstriction; Vasodilation | 2011 |
Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart.
Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left | 2011 |
Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin.
Topics: Animals; Blotting, Western; Carbazoles; Cells, Cultured; Ceramides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dinitrochlorobenzene; Genes, bcl-2; Minocycline; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Thioredoxins | 2011 |
Pharmacological evidence that Ca²+ channels and, to a lesser extent, K+ channels mediate the relaxation of testosterone in the canine basilar artery.
Topics: 4-Aminopyridine; Adenine; Aminoglutethimide; Androgen Receptor Antagonists; Animals; Aromatase Inhibitors; Barium Compounds; Basilar Artery; Calcium Channel Blockers; Calcium Channels; Chlorides; Cycloheximide; Dactinomycin; Dogs; Enzyme Inhibitors; Flutamide; In Vitro Techniques; Male; Nifedipine; Nucleic Acid Synthesis Inhibitors; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Protein Synthesis Inhibitors; Quinoxalines; Testosterone; Vasodilation; Vasodilator Agents | 2011 |
Pulmonary and systemic vasodilator responses to the soluble guanylyl cyclase activator, BAY 60-2770, are not dependent on endogenous nitric oxide or reduced heme.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzoates; Biphenyl Compounds; Guanylate Cyclase; Heme; Hydrocarbons, Fluorinated; Hypertension, Pulmonary; Male; Monocrotaline; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2011 |
Phosphodiesterase 3A expression is modulated by nitric oxide in rat pulmonary artery smooth muscle cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Gene Expression; Guanylate Cyclase; Interleukin-1beta; Lysine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; S-Nitrosoglutathione; Soluble Guanylyl Cyclase; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2010 |
Involvement of a NO-cyclic GMP-PKG signaling pathway in nitrous oxide-induced antinociception in mice.
Topics: Analgesics; Animals; Benzoates; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Imidazoles; Male; Mice; Naphthyridines; Nitric Oxide; Nitrous Oxide; Oxadiazoles; Pyrimidines; Quinoxalines; Signal Transduction; Thionucleotides | 2011 |
Modulating iNOS-uncoupling: a new therapeutic avenue to tackle reperfusion-injury?
Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left | 2011 |
A fundamental role for NO-PLC signaling pathway in mediating intracellular Ca2+ oscillation in pancreatic acini.
Topics: Animals; Calcium; Carcinoma, Acinar Cell; Estrenes; Inositol 1,4,5-Trisphosphate; Macrocyclic Compounds; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Oxazoles; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sincalide; Type C Phospholipases | 2011 |
Atorvastatin prevents vascular hyporeactivity to norepinephrine in sepsis: role of nitric oxide and α₁-adrenoceptor mRNA expression.
Topics: Animals; Atorvastatin; Enzyme Inhibitors; Guanylate Cyclase; Heptanoic Acids; Mice; Nitric Oxide; Norepinephrine; Oxadiazoles; Polymerase Chain Reaction; Pyrroles; Quinoxalines; Receptors, Adrenergic, alpha-1; RNA, Messenger; Sepsis; Vasoconstrictor Agents | 2011 |
Ruthenium-nitrite complex as pro-drug releases NO in a tissue and enzyme-dependent way.
Topics: Animals; Aorta, Thoracic; Guanylate Cyclase; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phenylephrine; Phosphoric Diester Hydrolases; Prodrugs; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ruthenium Compounds; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2011 |
Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus.
Topics: Acetylcholine; Animals; Callithrix; Carbolines; Crotalus; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Penis; Pyrazoles; Pyridines; Quinoxalines; Sodium Channel Blockers; Sodium Channels; Tadalafil; Tetrodotoxin; Vasodilator Agents | 2011 |
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one induces cell cycle arrest and apoptosis in HeLa cells by preventing microtubule polymerization.
Topics: Apoptosis; Cell Cycle; Enzyme Inhibitors; Guanylate Cyclase; HeLa Cells; Humans; Microtubules; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Tubulin | 2011 |
Tadalafil analgesia in experimental arthritis involves suppression of intra-articular TNF release.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Carbolines; Chemokine CXCL1; Chemokines; Cyclic GMP; Guanylate Cyclase; Injections, Intra-Articular; Interleukin-1; Joints; Male; Naloxone; Narcotic Antagonists; Neutrophils; Nociception; Osteoarthritis; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Tadalafil; Tumor Necrosis Factor-alpha; Zymosan | 2011 |
Developmental changes in mesenteric artery reactivity in embryonic and newly hatched chicks.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Animals, Newborn; Body Weight; Chick Embryo; Chickens; Colforsin; Embryonic Development; Endothelin-1; Enzyme Inhibitors; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Oxadiazoles; Potassium Chloride; Quinoxalines; Vasoconstriction; Vasodilation | 2011 |
Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
Topics: Actins; Analysis of Variance; Angioplasty, Balloon, Coronary; Animals; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Guanylate Cyclase; Hyperplasia; Intermediate Filaments; Molsidomine; Myosins; NAD(P)H Dehydrogenase (Quinone); NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction; Sus scrofa; Time Factors; Tunica Intima | 2011 |
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic | 2011 |
Ketamine activates the L-arginine/Nitric oxide/cyclic guanosine monophosphate pathway to induce peripheral antinociception in rats.
Topics: Analgesia; Anesthetics, Dissociative; Animals; Arginine; Cyclic AMP; Dinoprostone; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Hyperalgesia; Ketamine; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Pain; Peripheral Nervous System Diseases; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Indazoles; Mice; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones | 2011 |
Direct vasoactive properties of thienopyridine-derived nitrosothiols.
Topics: Animals; Aorta, Thoracic; Clopidogrel; Glutathione; Guanylate Cyclase; Hydrogen-Ion Concentration; In Vitro Techniques; Luminescent Measurements; Male; Mass Spectrometry; Molecular Structure; Nitro Compounds; Oxadiazoles; Ozone; Piperazines; Prasugrel Hydrochloride; Quinoxalines; Rabbits; S-Nitrosothiols; Sodium Nitrite; Spectrophotometry, Ultraviolet; Thienopyridines; Thiophenes; Ticlopidine; Vasodilation; Vasodilator Agents | 2011 |
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
Topics: Animals; Benzoates; Cells, Cultured; Cyclic GMP; Disease Models, Animal; Female; Fetus; Guanylate Cyclase; Humans; Hydrogen Peroxide; Infant, Newborn; Isoenzymes; Myocytes, Smooth Muscle; Nitric Oxide; Nitroprusside; Oxadiazoles; Persistent Fetal Circulation Syndrome; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vascular Resistance; Vasodilation; Vasodilator Agents | 2011 |
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea | 2011 |
Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Topics: Animals; Binding Sites; Cattle; Computer Simulation; Dogs; Guinea Pigs; Haplorhini; Humans; Magnetic Resonance Spectroscopy; Mice; Oxadiazoles; Oxidation-Reduction; Piperidines; Protein Binding; Protein Structure, Tertiary; Quinoxalines; Rats; Receptors, G-Protein-Coupled; Temperature; Xanthine Oxidase | 2011 |
Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats.
Topics: Animals; Arginine; Avoidance Learning; Cognition; Guanylate Cyclase; Indazoles; Male; Memory; Memory, Short-Term; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Retention, Psychology; Soluble Guanylyl Cyclase | 2011 |
The role of capillarisin from Artemisia capillaris on penile erection.
Topics: Animals; Artemisia; Chromones; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Ethanol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Phosphodiesterase 5 Inhibitors; Plant Extracts; Quinoxalines; Rabbits; Radioimmunoassay; Signal Transduction | 2012 |
Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
Topics: Animals; Basal Ganglia; Corpus Striatum; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Parkinsonian Disorders; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2011 |
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation of vascular smooth muscle cells: involvement of NO/cGMP/PKG pathway.
Topics: Animals; Becaplermin; Carbazoles; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Glucosides; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polygonum; Proto-Oncogene Proteins c-sis; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Stilbenes | 2012 |
Intermedin elicits a negative inotropic effect in rat papillary muscles mediated by endothelial-derived nitric oxide.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heart; Microvessels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Papillary Muscles; Peptide Fragments; Quinoxalines; Rats; Rats, Wistar; Troponin I | 2012 |
Endothelial dysfunction in the human umbilical artery due to preeclampsia can be prevented by sildenafil.
Topics: Adolescent; Adult; Case-Control Studies; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Piperazines; Pre-Eclampsia; Pregnancy; Purines; Quinoxalines; Sildenafil Citrate; Sulfones; Umbilical Arteries; Vasodilation; Vasodilator Agents; Young Adult | 2012 |
Possible involvement of S-nitrosylation of brain cyclooxygenase-1 in bombesin-induced central activation of adrenomedullary outflow in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenal Medulla; Animals; Benzoates; Bombesin; Brain; Catecholamines; Cysteine; Dithiothreitol; Dose-Response Relationship, Drug; Ethylmaleimide; Imidazoles; Injections, Intraventricular; Male; Molsidomine; Nitric Oxide Donors; Oxadiazoles; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; S-Nitrosothiols; Sulfhydryl Reagents | 2012 |
Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Cyclic GMP; Depression; Enzyme Inhibitors; Guanylate Cyclase; Hippocampus; Indazoles; Male; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Stress, Psychological; Swimming | 2012 |
Furoxans (1,2,5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents.
Topics: Amyloid beta-Peptides; Animals; Cells, Cultured; Crystallography, X-Ray; Cysteine; Guanylate Cyclase; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Donors; Nootropic Agents; Oxadiazoles; Peptidomimetics; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Stereoisomerism; Structure-Activity Relationship; Synapses | 2012 |
Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats.
Topics: Analgesics; Animals; Arginine; Carcinoma 256, Walker; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; KATP Channels; Male; Nitric Oxide; Nociception; Oxadiazoles; Pain Measurement; Pain Threshold; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2012 |
Peroxynitrite has potent pulmonary vasodilator activity in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Male; Molsidomine; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Peroxynitrous Acid; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2012 |
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.
Topics: Animals; Biguanides; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Spermidine | 2012 |
Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.
Topics: Animals; Anticestodal Agents; Antiplatyhelmintic Agents; Cell Line; Drug Evaluation, Preclinical; Echinococcus granulosus; Fasciola hepatica; Fibroblasts; Helminth Proteins; Humans; Larva; Lymphocytes; Mice; Models, Molecular; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxadiazoles; Quantum Theory; Quinoxalines; Structure-Activity Relationship; Thiadiazoles | 2012 |
Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate cyclase stimulator BAY 41-2272 in mouse gastric fundus and colon.
Topics: Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2012 |
The relaxant action of nicorandil in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Cromakalim; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Peptides; Quinoxalines; Trachea; Vasodilator Agents | 2012 |
Relative contribution of SKCa and TREK1 channels in purinergic and nitrergic neuromuscular transmission in the rat colon.
Topics: Animals; Apamin; Colon; Cysteine; Male; Methionine; Muscle Relaxation; Nitroarginine; Nitroprusside; Oxadiazoles; Peptides; Potassium Channel Blockers; Potassium Channels, Tandem Pore Domain; Quinoxalines; Rats; Rats, Sprague-Dawley; Small-Conductance Calcium-Activated Potassium Channels; Synaptic Transmission | 2012 |
Nebivolol-induced vasodilation of renal afferent arterioles involves β3-adrenergic receptor and nitric oxide synthase activation.
Topics: Animals; Arterioles; Benzopyrans; Enzyme Activation; Ethanolamines; Guanylate Cyclase; In Vitro Techniques; Kidney; Male; Metoprolol; Nebivolol; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Perfusion; Propanolamines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-3; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2012 |
Cyclic GMP/protein kinase G type-Iα (PKG-Iα) signaling pathway promotes CREB phosphorylation and maintains higher c-IAP1, livin, survivin, and Mcl-1 expression and the inhibition of PKG-Iα kinase activity synergizes with cisplatin in non-small cell lung c
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cisplatin; Cyclic AMP Response Element-Binding Protein; Cyclic GMP-Dependent Protein Kinase Type I; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Oxadiazoles; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; RNA, Small Interfering; Signal Transduction; Survivin | 2012 |
Effect of nitric oxide on epithelial ion transports in noncystic fibrosis and cystic fibrosis human proximal and distal airways.
Topics: Adenosine Triphosphate; Adult; Aged; Amiloride; Bronchi; Chloride Channels; Colforsin; Cyclic GMP; Cyclic N-Oxides; Cystic Fibrosis; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Free Radical Scavengers; Guanylate Cyclase; Humans; Imidazoles; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Purinones; Quinoxalines; Young Adult | 2012 |
The 2-nitrate-1,3-dibuthoxypropan, a new nitric oxide donor, induces vasorelaxation in mesenteric arteries of the rat.
Topics: Animals; Free Radical Scavengers; Glycerol; Guanylate Cyclase; In Vitro Techniques; Intracellular Space; Male; Mesenteric Arteries; Myocytes, Smooth Muscle; Nitrates; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Propane; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vasoconstriction; Vasodilation; Vasodilator Agents | 2012 |
Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Anion Transport Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Inhibitors; Imidazoles; Kidney Tubules, Collecting; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Oxadiazoles; Quinoxalines; Sulfate Transporters; Triazines | 2012 |
Dorzolamide-induced relaxation of intraocular porcine ciliary arteries in vitro depends on nitric oxide and the vascular endothelium.
Topics: Acetazolamide; Animals; Carbon Dioxide; Carbonic Anhydrase Inhibitors; Ciliary Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen-Ion Concentration; Isometric Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Sulfonamides; Swine; Thiazines; Thiophenes; Vasodilation; Vasodilator Agents | 2012 |
The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite.
Topics: Animals; Benzoates; Cyclic GMP; Guanidines; Guanylate Cyclase; Imidazoles; Isothiuronium; Larva; Metamorphosis, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Thoracica | 2012 |
Essential role of nitric oxide in acute ischemic preconditioning: S-nitros(yl)ation versus sGC/cGMP/PKG signaling?
Topics: Animals; Ascorbic Acid; Carbazoles; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Ischemic Preconditioning, Myocardial; Male; Mice; Mice, Inbred C57BL; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrosation; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Reperfusion Injury; Signal Transduction | 2013 |
cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control.
Topics: Animals; Aorta; Binding Sites; Blood Pressure; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Disulfides; Enzyme Activation; HEK293 Cells; Humans; Hydrogen Peroxide; Immunoblotting; In Vitro Techniques; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxidants; Oxidation-Reduction; Phosphorylation; Quinoxalines; Rats; Spermine; Vasodilation | 2012 |
[Peripheral mechanisms of action of oxatriazolium-5-olate derivative 3-(3-[1,2,4]-triazolo)oxatriazolium-5-olate in spontaneously hypertensive rats].
Topics: Animals; Arteries; Guanylate Cyclase; Heme; Male; Nitric Oxide; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Wistar; Tail; Tissue Culture Techniques; Triazoles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2012 |
S-nitrosylation inhibits pannexin 1 channel function.
Topics: Adenosine Triphosphate; Amino Acid Substitution; Animals; Connexins; Dithiothreitol; Glutathione; HEK293 Cells; Humans; Mice; Mutation; Mutation, Missense; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Oxadiazoles; Oxidation-Reduction; Quaternary Ammonium Compounds; Quinoxalines | 2012 |
In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet.
Topics: Animals; Blood Pressure; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diet, Sodium-Restricted; Enzyme Inhibitors; Kidney; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prorenin Receptor; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Signal Transduction | 2012 |
Mitochondrial-associated nitric oxide synthase activity inhibits cytochrome c oxidase: implications for breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Electron Transport Complex IV; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Guanylate Cyclase; Humans; Hydrogen Peroxide; Mitochondria; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Oxygen Consumption; Phosphorylation; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Quinoxalines | 2013 |
Cinnamyl alcohol attenuates vasoconstriction by activation of K⁺ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dipeptides; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phenylephrine; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Propanols; Quinoxalines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilation | 2012 |
Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Hypoglycemic Agents; Ileitis; Inflammation Mediators; KATP Channels; Lymphatic Vessels; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Potassium Channels, Inwardly Rectifying; Quinoxalines; Receptors, Drug; Sulfonylurea Receptors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
Inducible NOS mediates CNP-induced relaxation of intestinal myofibroblasts.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Humans; Mice; Muscle Relaxation; Myofibroblasts; Natriuretic Peptide, C-Type; Nitric Oxide Synthase Type II; Nitroarginine; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2013 |
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Area Under Curve; Atropine; Blood Pressure; Diamines; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Male; Muscarinic Antagonists; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Peripheral Nerve Injuries; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Time Factors | 2013 |
Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.
Topics: Analysis of Variance; Animals; Aorta; Barium Compounds; Calcium Chloride; Chlorides; Endothelium, Vascular; Glyburide; Indomethacin; Male; Methoxamine; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasodilation; Vasodilator Agents; Xanthones | 2012 |
Alteration of neuromuscular transmissions in the hamster colon following the resolution of TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Cricetinae; Electric Stimulation; Male; Mesocricetus; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peristalsis; Quinoxalines; Receptors, Tachykinin; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2013 |
The sGC activator BAY 60-2770 has potent erectile activity in the rat.
Topics: Animals; Benzoates; Biphenyl Compounds; Blood Pressure; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; Hydrocarbons, Fluorinated; Injections; Male; Nerve Crush; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Peripheral Nerves; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2013 |
Role of endothelium, acetylocholine and calcium ions in Bay K8644- and KCl-induced contraction.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Animals; Arteries; Calcium; Calcium Channel Agonists; Calcium Channels; Endothelium, Vascular; Guanylate Cyclase; Ions; Male; Muscle Contraction; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2013 |
Cyclic guanosine monophosphate and the dependent protein kinase regulate lymphatic contractility in rat thoracic duct.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Isoenzymes; Lymphatic Vessels; Male; Muscle Contraction; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Thoracic Duct | 2013 |
Imatinib mesylate (Gleevec) induces human corpus cavernosum relaxation by inhibiting receptor tyrosine kinases (RTKs): identification of new RTK targets.
Topics: Adult; Aged; Apamin; Benzamides; Enzyme Activation; Erectile Dysfunction; Humans; Imatinib Mesylate; In Vitro Techniques; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Oxadiazoles; Penis; Phosphorylation; Piperazines; Potassium Channel Blockers; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Quinoxalines; Receptor Protein-Tyrosine Kinases; Tetraethylammonium | 2013 |
Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats.
Topics: Animals; Anxiety; Apomorphine; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; GABA-A Receptor Antagonists; Male; Maze Learning; Nitric Oxide Synthase; Oxadiazoles; Periaqueductal Gray; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Quinoxalines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2013 |
Lasting neurobehavioral abnormalities in rats after neonatal activation of serotonin 1A and 1B receptors: possible mechanisms for serotonin dysfunction in autistic spectrum disorders.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Animals, Newborn; Brain; Citalopram; Exploratory Behavior; Female; Freezing Reaction, Cataleptic; Locomotion; Male; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Rats; Rats, Long-Evans; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1B; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Social Behavior | 2014 |
Analysis of the mechanisms underlying the antinociceptive effect of epicatechin in diabetic rats.
Topics: Analgesics; Animals; Biphenyl Compounds; Catechin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Female; Glyburide; Hyperalgesia; Indazoles; Methiothepin; Naloxone; NG-Nitroarginine Methyl Ester; Oxadiazoles; Pain Measurement; Piperazines; Piperidones; Pyridines; Quinoxalines; Rats; Spiro Compounds | 2013 |
Ovariectomy increases the participation of hyperpolarizing mechanisms in the relaxation of rat aorta.
Topics: Acetylcholine; Animals; Aorta; Catalase; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Gene Expression; Guanylate Cyclase; Hydrogen Peroxide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Ovariectomy; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Tissue Culture Techniques; Vasodilation; Vasodilator Agents | 2013 |
The role of aquaporin 1 activated by cGMP in myocardial edema caused by cardiopulmonary bypass in sheep.
Topics: Animals; Aquaporin 1; Cardiopulmonary Bypass; Cyclic GMP; Edema, Cardiac; Female; Myocytes, Cardiac; Oxadiazoles; Quinoxalines; Sheep, Domestic | 2013 |
Underlying mechanisms involved in progesterone-induced relaxation to the pig bladder neck.
Topics: Animals; Calcium; Cyclooxygenase Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Potassium; Potassium Channel Blockers; Potassium Channels; Progesterone; Quinoxalines; Receptors, Progesterone; Swine; Urinary Bladder; Urothelium | 2014 |
Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility.
Topics: Adult; Cell Physiological Phenomena; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Guanylate Cyclase; Humans; Infant; Middle Aged; Myosin Light Chains; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Phosphorylation; Quinoxalines; Tissue Donors; Trabecular Meshwork; Triazenes | 2014 |
Preservation of nitric oxide-induced relaxation of porcine coronary artery: roles of the dimers of soluble guanylyl cyclase, phosphodiesterase type 5, and cGMP-dependent protein kinase.
Topics: Animals; Coronary Vessels; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Phosphodiesterase 5 Inhibitors; Protein Kinase Inhibitors; Protein Multimerization; Purinones; Quinoxalines; Swine; Vasodilation | 2014 |
The nitric oxide donor SNAP-induced amino acid neurotransmitter release in cortical neurons. Effects of blockers of voltage-dependent sodium and calcium channels.
Topics: Amino Acids; Animals; Benzoates; Calcium Channel Blockers; Calcium Channels; Cell Survival; Cerebral Cortex; Female; Guanylate Cyclase; Imidazoles; Membrane Potentials; Models, Biological; Neurons; Neurotransmitter Agents; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Sodium Channel Blockers; Sodium Channels; Soluble Guanylyl Cyclase | 2014 |
Effects of 7-NI and ODQ on memory in the passive avoidance, novel object recognition, and social transmission of food preference tests in mice.
Topics: Animals; Anxiety; Arginine; Avoidance Learning; Exploratory Behavior; Food Preferences; Indazoles; Male; Memory; Mice; Mice, Inbred BALB C; Motor Activity; Oxadiazoles; Quinoxalines; Smell; Social Behavior | 2014 |
Vasodilator responses to acetylcholine are not mediated by the activation of soluble guanylate cyclase or TRPV4 channels in the rat.
Topics: Acetylcholine; Animals; Arterial Pressure; Bradykinin; Enzyme Inhibitors; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2014 |
The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats.
Topics: Animals; Biological Factors; Electric Stimulation; Glyburide; Hemodynamics; Indomethacin; Male; Nitric Oxide; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Succinates; Sympathetic Nervous System; Synaptic Transmission | 2014 |
Involvement of H1 and H2 receptors and soluble guanylate cyclase in histamine-induced relaxation of rat mesenteric collecting lymphatics.
Topics: Animals; Cimetidine; Endothelium, Lymphatic; Guanylate Cyclase; Histamine H1 Antagonists; Histamine H2 Antagonists; Lymphatic Vessels; Male; Mesentery; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrilamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Histamine H1; Receptors, Histamine H2; Soluble Guanylyl Cyclase | 2014 |
The stimulating effects of nitric oxide on intermediate conductance Ca²⁺-activated K⁺ channels in human dermal fibroblasts through PKG pathways but not the PKA pathways.
Topics: 4-Aminopyridine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dermis; Enzyme Inhibitors; Fibroblasts; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Quinoxalines; Signal Transduction; Toxins, Biological; Wound Healing | 2014 |
Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenosine Triphosphate; Animals; Arachidonic Acid; Collagen; Cyclic GMP; Guanylate Cyclase; Humans; Iridoids; MAP Kinase Signaling System; Mice; Oxadiazoles; Phospholipase C gamma; Plant Extracts; Platelet Activation; Protein Kinase C; Quinoxalines; Thrombin; Thromboembolism; Thrombosis | 2014 |
Involvement of nitric oxide and ATP-sensitive potassium channels in the peripheral antinoceptive action of a tramadol-dexketoprofen combination in the formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glyburide; KATP Channels; Ketoprofen; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain Measurement; Quinoxalines; Tramadol; Tromethamine | 2014 |
Soluble guanylyl cyclase activators increase the expression of tolerance to morphine analgesic effect.
Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Male; Molsidomine; Morphine; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Photosensitizing Agents; Protoporphyrins; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Restriction Mapping; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase | 2014 |
Dorzolamide-induced relaxation of porcine retinal arterioles in vitro depends on nitric oxide but not on acidosis in vascular smooth muscle cells.
Topics: Acidosis; Animals; Arterioles; Benzopyrans; Bradykinin; Carbonic Anhydrase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Dyes; Hydrogen-Ion Concentration; Lactates; Muscle, Smooth, Vascular; Myography; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Retinal Artery; Sulfonamides; Swine; Thiophenes; Vasodilation | 2014 |
A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.
Topics: Animals; Bradykinin; Carbenoxolone; Catalase; Colforsin; Coronary Vessels; Female; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Ouabain; Oxadiazoles; Peptides; Polyethylene Glycols; Quinoxalines; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents; Vasodilation; Verapamil | 2014 |
The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Glyburide; Guanidines; Guanylate Cyclase; KATP Channels; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Nociception; Ornithine; Oxadiazoles; Pain Measurement; Physical Conditioning, Animal; Quinoxalines; Rats; Signal Transduction | 2015 |
Linalool elicits vasorelaxation of mouse aortae through activation of guanylyl cyclase and K(+) channels.
Topics: Acyclic Monoterpenes; Animals; Aorta; Calcium; Calcium Chloride; Dinoprost; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Activation; Guanylate Cyclase; Male; Mice; Monoterpenes; NG-Nitroarginine Methyl Ester; Oxadiazoles; Potassium Channels; Quinoxalines; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2015 |
Nitric oxide augments single Ca(2+) channel currents via cGMP-dependent protein kinase in Kenyon cells isolated from the mushroom body of the cricket brain.
Topics: Action Potentials; Animals; Brain; Calcium Channels; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gryllidae; Male; Mushroom Bodies; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; Signal Transduction | 2015 |
5-HT1D receptor inhibits renal sympathetic neurotransmission by nitric oxide pathway in anesthetized rats.
Topics: Animals; Blood Pressure; Heart Rate; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Sympathetic Nervous System; Synaptic Transmission; Tryptamines | 2015 |
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Cadmium Chloride; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; Morpholines; Neurons; Oxadiazoles; Presynaptic Terminals; Pyrimidines; Quinoxalines; Rats; Rats, Wistar | 2015 |
Relaxin Affects Smooth Muscle Biophysical Properties and Mechanical Activity of the Female Mouse Colon.
Topics: Animals; Biophysical Phenomena; Calcium; Calcium Channels, L-Type; Carbazoles; Colon; Cyclic GMP-Dependent Protein Kinases; Female; Gastrointestinal Motility; Guanylate Cyclase; KATP Channels; Membrane Potentials; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Myocytes, Smooth Muscle; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Quinoxalines; Receptors, G-Protein-Coupled; Relaxin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcolemma | 2015 |
The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats.
Topics: Animals; Benzoates; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Guanylate Cyclase; Isoproterenol; Muscle Relaxation; Myocardial Contraction; Myocytes, Cardiac; Oxadiazoles; Pyrazoles; Pyrimidines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Thionucleotides; Verapamil | 2015 |
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells.
Topics: Coculture Techniques; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelial Cells; Humans; Indomethacin; Myocytes, Smooth Muscle; Nitroarginine; Oxadiazoles; Quinoxalines; Receptors, G-Protein-Coupled; Receptors, Peptide; Recombinant Proteins; Relaxin; Signal Transduction; Umbilical Arteries; Umbilical Veins | 2016 |
Cyclic GMP-mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice.
Topics: Animals; Carbazoles; Cell Adhesion Molecules; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Guanylate Cyclase; Imidazoles; Male; Memory; Mice, Inbred ICR; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoproteins; Protein Kinase Inhibitors; Quinoxalines; Recognition, Psychology; Triazines | 2016 |
Effects of NO Donors and Inhibitors of NO Synthase and Guanylate Cyclase on the Acquisition of a Conditioned Defense Food Aversion Response in Edible Snails.
Topics: Animals; Conditioning, Psychological; Enzyme Inhibitors; Guanylate Cyclase; Iron; Learning; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Quinoxalines; Shellfish; Snails | 2016 |
NMDA-NO signaling in the dorsal and ventral hippocampus time-dependently modulates the behavioral responses to forced swimming stress.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Cobalt; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hippocampus; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Swimming | 2016 |
Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser.
Topics: Animals; Guanylate Cyclase; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penis; Phosphodiesterase 5 Inhibitors; Photic Stimulation; Quinoxalines; Rats, Wistar; Vardenafil Dihydrochloride | 2016 |
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2016 |
Endothelium- and smooth muscle-dependent vasodilator effects of Citrus aurantium L. var. amara: Focus on Ca(2+) modulation.
Topics: Animals; Aorta; Calcium; Citrus; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Space; Isometric Contraction; Male; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Oils, Volatile; Oxadiazoles; Phenylephrine; Quinoxalines; Ryanodine Receptor Calcium Release Channel; Vasodilation; Vasodilator Agents | 2016 |
Modulation of growth cone filopodial length by carbon monoxide.
Topics: Action Potentials; Animals; Calcium; Carbazoles; Carbon Monoxide; Enzyme Inhibitors; Ganglia, Invertebrate; Growth Cones; Heme Oxygenase-1; Neurons; Nitric Oxide; Organometallic Compounds; Oxadiazoles; Oxazines; Patch-Clamp Techniques; Pseudopodia; Quinoxalines; Signal Transduction; Snails; Time Factors | 2017 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glyburide; In Vitro Techniques; KATP Channels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nicorandil; Oxadiazoles; Peptides; Pinacidil; Potassium; Quinoxalines; Rats | 2016 |
Nicorandil inhibits osteoclast differentiation in vitro.
Topics: Animals; Cell Differentiation; Dose-Response Relationship, Drug; Humans; KATP Channels; Mice; Nicorandil; Nitric Oxide; Osteoclasts; Oxadiazoles; Quinoxalines; Soluble Guanylyl Cyclase | 2016 |
In vitro and in vivo assessment of newer quinoxaline-oxadiazole hybrids as antimicrobial and antiprotozoal agents.
Topics: Animals; Anti-Infective Agents; Bacteria; Chagas Disease; Disease Models, Animal; Fungi; Male; Mice; Molecular Structure; Oxadiazoles; Quinoxalines; Trypanosoma cruzi | 2017 |
Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inhibitory Concentration 50; Mesothelioma; Oxadiazoles; Phosphorylation; Phosphorylcholine; Pleural Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinoxalines; Sulfonamides; Thiadiazoles; Thiophenes | 2017 |
Soluble guanylyl cyclase is a critical regulator of migraine-associated pain.
Topics: Adrenergic beta-Antagonists; Allosteric Regulation; Animals; Anticonvulsants; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme Inhibitors; Female; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Migraine Disorders; Molecular Targeted Therapy; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Oxadiazoles; Propranolol; Proto-Oncogene Proteins c-fos; Quinoxalines; Serotonin 5-HT1 Receptor Agonists; Soluble Guanylyl Cyclase; Sumatriptan; Topiramate | 2018 |
Activation of Secretagogue Independent Gastric Acid Secretion via Endothelial Nitric Oxide Synthase Stimulation in Rats.
Topics: Animals; Arginine; Gastric Acid; H(+)-K(+)-Exchanging ATPase; Hydrogen-Ion Concentration; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Parietal Cells, Gastric; Quinoxalines; Rats; Rats, Sprague-Dawley | 2017 |
Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.
Topics: Animals; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; HSP27 Heat-Shock Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Receptor, PAR-2; Receptors, Muscarinic; Structure-Activity Relationship; Vasodilation | 2018 |
Effects of Nitric Oxide on Voltage-Gated K⁺ Currents in Human Cardiac Fibroblasts through the Protein Kinase G and Protein Kinase A Pathways but Not through S-Nitrosylation.
Topics: Action Potentials; Adenine; Carbazoles; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Myofibroblasts; Nitric Oxide; Oxadiazoles; Potassium Channels, Voltage-Gated; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2018 |
Endothelial modulation of a nitric oxide donor complex-induced relaxation in normotensive and spontaneously hypertensive rats.
Topics: Animals; Coordination Complexes; Dose-Response Relationship, Drug; Endothelium, Vascular; Guanylate Cyclase; Male; Mesenteric Arteries; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oxadiazoles; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Inbred SHR; Ruthenium; Vascular Resistance; Vasodilation | 2018 |
Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery.
Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2018 |
Different vasodilator mechanisms in intermediate- and small-sized arteries from the hindlimb vasculature of the toad
Topics: Animals; Arteries; Bufo marinus; Female; Hindlimb; Humans; Immunohistochemistry; Male; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasodilation | 2019 |
Role of Carbon Monoxide in the Mechanisms of Action of Extracellular ATP on Contractile Activity of Vascular Smooth Muscle Cells.
Topics: Adenosine Triphosphate; Animals; Aorta; Carbon Monoxide; Cells, Cultured; Endothelium; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Organometallic Compounds; Oxadiazoles; Phenylephrine; Protoporphyrins; Purinergic P2X Receptor Agonists; Purinergic P2Y Receptor Agonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P2X; Receptors, Purinergic P2Y | 2019 |
Differentiation-inducing factor-1 prevents hepatic stellate cell activation through inhibiting GSK3β inactivation.
Topics: Active Transport, Cell Nucleus; Adenine; Animals; Antineoplastic Agents; beta Catenin; Cell Differentiation; Cell Transdifferentiation; Dictyostelium; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta; Hepatic Stellate Cells; Hexanones; Liver Cirrhosis; Mice; Oxadiazoles; Phosphorylation; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction | 2019 |
Perivascular adipose tissue phenotype and sepsis vascular dysfunction: Differential contribution of NO, ROS and beta 3-adrenergic receptor.
Topics: Acetophenones; Adipose Tissue; Adrenergic beta-3 Receptor Agonists; Animals; Aorta; Cyclic N-Oxides; Female; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Oxadiazoles; Phenotype; Quinoxalines; Rats; Reactive Oxygen Species; Receptors, Adrenergic, beta-3; Sepsis; Spin Labels; Vasoconstriction | 2020 |
Nitric oxide in the insular cortex modulates baroreflex responses in a cGMP-independent pathway.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Heart Rate; Imidazoles; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2020 |
Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein.
Topics: Antineoplastic Agents; Apoptosis; Density Functional Theory; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-α-Induced Expression of Glial Fibrillary Acid Protein.
Topics: Animals; Astrocytes; Boron Compounds; Calcium Channel Blockers; Calcium Signaling; Cell Line, Tumor; Corpus Striatum; Cyclic GMP; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Humans; Imines; Interleukin-6; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Ryanodine; Tumor Necrosis Factor-alpha | 2021 |
Synthesis of [1,2,4]triazolo[4,3-a]quinoxaline-1,3,4-oxadiazole derivatives as potent antiproliferative agents via a hybrid pharmacophore approach.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Oxadiazoles; Quinoxalines; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured | 2020 |
Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies.
Topics: Achillea; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Computer Simulation; Heart Rate; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Plant Extracts; Quinoxalines; Rats, Inbred SHR; Rats, Wistar; Sesquiterpenes; Vasodilator Agents | 2021 |
New quinoxalin-1,3,4-oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies.
Topics: Carbonic Anhydrase Inhibitors; Cholinesterase Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Models, Molecular; Molecular Docking Simulation; Oxadiazoles; Quinoxalines; Structure-Activity Relationship | 2021 |
Efficient Synthetic Access to Novel Indolo[2,3-
Topics: Heterocyclic Compounds; Oxadiazoles; Quinoxalines; Spectroscopy, Fourier Transform Infrared; Thiadiazoles | 2022 |
Inhibition of endogenous ouabain by atrial natriuretic peptide is a guanylyl cyclase independent effect.
Topics: Adrenal Cortex; Atrial Natriuretic Factor; Cell Line, Tumor; Cyclic GMP; Guanylate Cyclase; Humans; Ouabain; Oxadiazoles; Peptide Fragments; Quinoxalines; Radioimmunoassay; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Second Messenger Systems; Vasodilator Agents | 2021 |