quinoxalines has been researched along with licostinel in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 25 (67.57) | 18.2507 |
| 2000's | 11 (29.73) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bullock, R; Tsuchida, E | 1 |
| Guastella, J; Huettner, JE; Keana, JF; Weber, E; Woodward, RM | 1 |
| Martin, H; Todd, MM; Warner, DS | 1 |
| Dexter, F; McFarlane, C; Nader, A; Warner, DS | 1 |
| Barth, A; Malouf, AT; Newell, DW | 1 |
| Matsumoto, RR; Nguyen, D; Truong, DD | 1 |
| Keana, JF; Ludwig, P; Martin, H; McAllister, A; Warner, DS; Weber, E | 1 |
| Balster, RL; Cristello, AF; Wiley, JL | 1 |
| Bullock, R; Di, X | 1 |
| Erdõ, SL; Molnár, P | 1 |
| Lutfy, K; Weber, E | 1 |
| Han Hsu, H; Hawkinson, JE; Huber, KR; Sahota, PS; Weber, E; Whitehouse, MJ | 1 |
| Bart, RD; Brinkhous, A; Pearlstein, R; Takaoka, S; Warner, DS | 1 |
| Bart, RD; Pearlstein, RD; Takaoka, S; Warner, DS | 1 |
| Bettelini, L; Corsi, M; Fina, P; Trist, DG | 1 |
| Auer, RN | 1 |
| Breithecker, K; Koch, M; Kratzer, U; Kretschmer, BD | 1 |
| Brackett, RL; Kanthasamy, AG; Matsumoto, RR | 1 |
| Bart, RD; Morimoto, Y; Pearlstein, RD; Warner, DS; Wu, B | 1 |
| Beirne, JP; Massey, GW; Pearlstein, RD; Warner, DS | 1 |
| Lingenhöhl, K; Pozza, MF | 1 |
| Balster, RL; Compton, AD; Holcomb, JD; McCallum, SE; Porter, JH; Varvel, SA; Wiley, JL | 1 |
| Albers, GW; Atkinson, RP; Clark, WM; Data, JL; Madden, K; Whitehouse, MJ | 1 |
| Matsumoto, RR; Nour, M; Pouw, B | 1 |
| Balster, RL; Beardsley, PM; Bespalov, AY; Dravolina, OA; Zvartau, EE | 1 |
| Nishiyama, T | 2 |
| Laverty, R; Russell, BR | 2 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Keana, JF; Kher, SM; Tran, M; Weber, E; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
| Maynard, KI; Sarhan, S; Wettstein, JG | 1 |
| Juretschke, HP; Kalisch, J; Neumann-Haefelin, C; Petty, MA; Sarhan, S; Wettstein, JG | 1 |
| Balster, RL; Wiley, JL | 1 |
| Maynard, KI; Petty, MA; Weintraub, PM | 1 |
| Cai, SX | 1 |
| Leng, W; Qiu, W; Wang, W; Wei, R; Zhang, C | 1 |
1 review(s) available for quinoxalines and licostinel
| Article | Year |
|---|---|
ACEA 1021: flip or flop?
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2004 |
1 trial(s) available for quinoxalines and licostinel
| Article | Year |
|---|---|
Dose escalation study of the NMDA glycine-site antagonist licostinel in acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Brain Ischemia; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Quinoxalines | 1999 |
35 other study(ies) available for quinoxalines and licostinel
| Article | Year |
|---|---|
The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat.
Topics: Animals; Binding, Competitive; Blood Pressure; Brain Ischemia; Excitatory Amino Acid Antagonists; Glycine; Hematoma, Subdural; Humans; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.
Topics: Animals; Binding Sites; Brain; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Electrophysiology; Female; Glycine; Kynurenic Acid; Neurons; Oocytes; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1995 |
Effects of glycine receptor antagonism on spreading depression in the rat.
Topics: Animals; Binding Sites; Cortical Spreading Depression; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Glycine; Ketamine; Macromolecular Substances; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat.
Topics: Animals; Binding, Competitive; Blood Pressure; Body Weight; Carbon Dioxide; Drug Interactions; Glycine; Halothane; Hydrogen-Ion Concentration; Male; Oxygen; Partial Pressure; Pulmonary Alveoli; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynurenic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
Strychnine-insensitive glycine site antagonists attenuate a cardiac arrest-induced movement disorder.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cardiopulmonary Resuscitation; Central Nervous System; Dose-Response Relationship, Drug; Felbamate; Heart Arrest; Male; Myoclonus; Phenylcarbamates; Propylene Glycols; Pyrrolidinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Stereoisomerism; Strychnine | 1995 |
In vivo models of cerebral ischemia: effects of parenterally administered NMDA receptor glycine site antagonists.
Topics: Animals; Brain Ischemia; Male; Nervous System; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
Effects of site-selective NMDA receptor antagonists in an elevated plus-maze model of anxiety in mice.
Topics: Amino Acids; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Modulators; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phencyclidine; Punishment; Quinoxalines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
Effect of the novel high-affinity glycine-site N-methyl-D-aspartate antagonist ACEA-1021 on 125I-MK-801 binding after subdural hematoma in the rat: an in vivo autoradiographic study.
Topics: Animals; Autoradiography; Brain; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hematoma, Subdural; Humans; Male; Quinoxalines; Rats; Rats, Sprague-Dawley | 1996 |
Differential effects of five glycine site antagonists on NMDA receptor desensitisation.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Attenuation of nociceptive responses by ACEA-1021, a competitive NMDA receptor/glycine site antagonist, in the mice.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Microinjections; Pain; Pain Measurement; Quinoxalines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1996 |
The N-methyl-D-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in rat brain.
Topics: Animals; Brain; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Glycine; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.
Topics: Animals; Binding Sites; Brain Damage, Chronic; Brain Ischemia; Cerebral Infarction; Excitatory Amino Acid Antagonists; Fever; Glycine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Temperature | 1997 |
Glycine antagonism does not block ischemic spontaneous depolarization in the rat.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ischemic Attack, Transient; Male; Membrane Potentials; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, Glycine | 1997 |
Estimation of the relative potency of two glycine antagonists on NMDA-induced depolarizations in BRSC and ARCS.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Potassium Chloride; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1997 |
Structural neurotoxicologic investigation of the glycine antagonist 5-nitro-6,7-dichloroquinoxalinedione (ACEA-1021).
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gyrus Cinguli; Male; Microscopy, Electron; Neurotoxins; Quinoxalines; Rats; Rats, Wistar; Receptors, Glycine; Survival Rate | 1997 |
ACEA 1021, a glycine site antagonist with minor psychotomimetic and amnestic effects in rats.
Topics: Amnesia; Animals; Antimetabolites; Behavior, Animal; Catalepsy; Cycloserine; Excitatory Amino Acid Antagonists; Exploratory Behavior; Hallucinogens; Male; Maze Learning; Motor Activity; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Reflex, Startle | 1997 |
Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Excitatory Amino Acid Antagonists; Male; Mice; Quinoxalines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Seizures | 1997 |
Effects of NMDA receptor glycine recognition site antagonism on cerebral metabolic rate for glucose and cerebral blood flow in the conscious rat.
Topics: Animals; Brain; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Glucose; Linear Models; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 1998 |
Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kainic Acid; L-Lactate Dehydrogenase; Neuroprotective Agents; Osmolar Concentration; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 1998 |
Reevaluation of ACEA 1021 as an antagonist at the strychnine-insensitive glycine site of the N-methyl-D-aspartate receptor.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Electrophysiology; Excitatory Amino Acid Antagonists; Hippocampus; Male; N-Methylaspartate; Neocortex; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 1998 |
Effects of modulation of NMDA neurotransmission on response rate and duration in a conflict procedure in rats.
Topics: 2-Amino-5-phosphonovalerate; Acetamides; Animals; Anti-Anxiety Agents; Chlordiazepoxide; Conditioning, Operant; Conflict, Psychological; Diazepam; Dose-Response Relationship, Drug; Electroshock; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reward; Synaptic Transmission | 1998 |
Licostinel. ACEA 1021.
Topics: Animals; Anticonvulsants; Craniocerebral Trauma; Drugs, Investigational; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Quinoxalines; Rats; Stroke | 1999 |
Effects of AMPA/kainate glutamate receptor antagonists on cocaine-induced convulsions and lethality in mice.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cocaine; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Male; Mice; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1999 |
Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.
Topics: Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; Piperazines; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Formaldehyde; Injections, Spinal; Male; Morphine; Motor Activity; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Interaction among NMDA receptor-, NMDA glycine site- and AMPA receptor antagonists in spinally mediated analgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Behavior, Animal; Binding Sites; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Injections, Spinal; Motor Activity; Nociceptors; Pain Measurement; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Correlation between 5-HT content and uptake site density following (S)-MDMA and dexfenfluramine-induced depletion, and with neuroprotection by the glycine site-specific NMDA antagonist ACEA 1021.
Topics: Animals; Animals, Newborn; Brain; Brain Chemistry; Dexfenfluramine; Drug Interactions; Male; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Paroxetine; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Agents; Tritium | 2000 |
The effect of (R)-HA966 or ACEA 1021 on dexfenfluramine or (S)-MDMA-induced changes in temperature, activity, and neurotoxicity.
Topics: Animals; Autoradiography; Body Temperature; Brain Chemistry; Carrier Proteins; Chromatography, High Pressure Liquid; Dexfenfluramine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; N-Methyl-3,4-methylenedioxyamphetamine; Nerve Tissue Proteins; Neurotoxicity Syndromes; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Stereoisomerism; Telemetry | 2001 |
Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2003 |
Delayed treatment with 5-nitro-6,7-dichloro-1,4-dihydro-2,3-quinoxalinedione, a glycine site N-methyl-D-aspartate antagonist, protects against permanent middle cerebral artery occlusion in male rats.
Topics: Animals; Brain; Brain Infarction; Infarction, Middle Cerebral Artery; Injections, Intravenous; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Time Factors | 2003 |
In vivo neuroprotective effects of ACEA 1021 confirmed by magnetic resonance imaging in ischemic stroke.
Topics: Animals; Behavior, Animal; Brain; Brain Infarction; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Injections, Subcutaneous; Magnetic Resonance Imaging; Male; Mice; Neuroprotective Agents; Psychomotor Performance; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion | 2003 |
Effects of modulators of N-methyl-D-aspartate receptor-mediated neurotransmission on diazepam discrimination in rats.
Topics: Amino Acids; Animals; Biguanides; Binding Sites; Conditioning, Operant; Diazepam; Discrimination, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agonists; Male; N-Methylaspartate; Pentobarbital; Phencyclidine; Piperazines; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Riluzole | 2004 |
Glycine/NMDA receptor antagonists as potential CNS therapeutic agents: ACEA-1021 and related compounds.
Topics: Animals; Central Nervous System; Excitatory Amino Acid Antagonists; Humans; Quinoxalines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2006 |
A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades.
Topics: Animals; Apoptosis; Cytoprotection; Eye Proteins; Frozen Sections; Gene Expression Regulation; Glycine; In Situ Nick-End Labeling; Ischemia; Male; Microscopy, Confocal; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retinal Ganglion Cells | 2010 |