Page last updated: 2024-08-17

quinoxalines and indomethacin

quinoxalines has been researched along with indomethacin in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19903 (5.00)18.7374
1990's14 (23.33)18.2507
2000's32 (53.33)29.6817
2010's11 (18.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amir, M; Somakala, K; Tariq, S1
Bennett, DR; Cochrane, RL; Powell, JG; Rathmacher, RP; Shaar, CJ; Smalstig, EB1
Hao, Q; Hauth, T; Hyman, A; Lippton, HL1
Nagao, T; Vanhoutte, PM1
Levine, JD; Taiwo, YO1
Barnes, PJ; Crawley, DE; Evans, TW; Liu, SF1
Harker, CT; Vanhoutte, PM1
Hollier, LH; Miller, VM; Reigel, MM; Vanhoutte, PM1
Limberger, N; Rump, LC; Trendelenburg, AU1
Black, JW; Saxena, PR; Shankley, NP; Van der Graaf, PH1
Li-Bo, Z; Matsuda, K; Sekiguchi, F; Shimamura, K; Sunano, S; Watanabe, H1
Cheung, PY; Schulz, R1
Barber, DA; Miller, VM1
Dinh, DT; Fabiani, ME; Story, DF1
Li, L; Paakkari, I; Vaali, K; Vapaatalo, H1
Endo, T; Hara, S; Iwata, N; Kano, S; Kuriiwa, F; Mukai, T; Yanase, T1
Chan, PH; Hirvonen, T; Keinänen, R; Koistinaho, J; Koponen, S; Närhi, M; Roivainen, R1
Koshita, M; Nakahira, Y; Suzuki, H; Takano, H1
Boyle, JP; Fish, HJ; Hanvesakul, R; Lacy, PS; Pilkington, G; Thurston, H1
Jiang, F; Li, CG; Rand, MJ1
Cole, WC; Dong, H; Jiang, Y; Triggle, CR1
Eguchi, D; Katusic, ZS1
Dusting, GJ; Jiang, F1
McKinnon, S; Paris, G; Pena, M; Sanford, K; Sponsel, WE; Trigo, Y; Weber, A1
Barreiro, EJ; Noël, F; Silva, CL1
Bryan, RM; Schildmeyer, LA1
Jang, CG; Kim, JH; Lee, SJ; Lee, SY; Sohn, UD; Yang, SI1
Boussery, K; Delaey, C; Van de Voorde, J1
Burgdorf, C; Engelhardt, A; Kurz, T; Richardt, G; Schäfer, U1
Anderson, TJ; Ellis, A; Pannirselvam, M; Triggle, CR1
Ambrosio, SR; da Costa, FB; de Oliveira, AM; Tirapelli, CR1
Jun, CH; Lee, TS; Sohn, UD1
Gendron, ME; Perrault, LP; Thorin, E1
Carvalho, LC; de Moura, RS; Madeira, SV; Miranda, DZ; Pinto, AC; Rangel, BM; Resende, AC; Rubenich, LM; Sicca, RF; Souza, MA; Tano, T1
Bendhack, LM; Sendão Oliveira, AP1
Benedito, S; García-Sacristán, A; Hernández, M; Martínez, AC; Prieto, D; Recio, P; Rivera, L1
Asada, Y; Kobayashi, H; Nao-i, N; Ohkura, M; Okano, M; Sawada, A; Tanaka, N; Uchikawa, Y; Wada, A; Yamamoto, R1
Jin, L; Palmer, T; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z1
Adamson, SL; Kulandavelu, S; Langille, BL; Quan, A; Ward, ME1
Cao, LH; Choi, DH; Kang, DG; Kim, JS; Kim, SJ; Lee, H; Lee, HS; Lee, JK1
Huang, ZQ; Xu, HB1
Bakker, LM; Chaytor, AT; Edwards, DH; Griffith, TM1
Malakul, W; Suvitayavat, W; Thirawarapan, S; Woodman, OL1
Bendhack, LM; Rocha, ML1
Azuma, H; Imamura, M; Isotani, E; Mizuno, Y; Nagai, A; Ohno, K1
Bose, R; Cheng, ZQ; Jacobs, H; Kasian, K; Light, RB; Mink, SN; Santos Martinez, LE1
Majewski, H; Zhao, J1
Ceballos-Reyes, G; Granados-Soto, V; Jiménez-Andrade, GY; Reyes-García, G; Sereno, G; Vidal-Cantú, GC1
Cunha, FQ; Duarte, DB; Ferrari, LF; Ferreira, SH; Funez, MI; Lorenzetti, BB; Parada, CA; Sachs, D1
Chen, J; Chen, X; Liu, J; Wang, T; Xiao, H; Yang, J; Ye, Z; Yin, C1
Bankar, GR; Bhattacharya, S; Nampurath, GK; Nayak, PG1
Man, RY; Ng, KF; Vanhoutte, PM; Wong, ES1
Andrade E Silva, ML; Bastos, JK; Carvalho, MT; Celotto, AC; Cunha, WR; Evora, PR; Rezende, KC1
Suksamrarn, S; Tep-Areenan, P1
Dou, B; Fan, J; Peng, X; Wang, J; Zhang, H; Zhang, S1
Blaha, I; Bustamante, S; Carballido, J; Fernandes, VS; García-Sacristán, A; Hernández, M; Martínez, AC; Martínez-Sáenz, A; Recio, P; Ribeiro, AS; Serrano-Margüello, D; Vázquez-Alba, D1
García, M; García-Pedraza, JÁ; Martín, ML; Morán, A; San Román, L1
Alexander, SP; Garle, MJ; Randall, MD; Roberts, RE; Wong, PS1
Bathgate, RA; Samuel, CS; Sarwar, M; Stewart, DR; Summers, RJ1
Chandrasekaran, G; Kumar, D; Kumar, T; Mahobiya, A; Parida, S; Rungsung, S; Singh, TU1

Reviews

1 review(s) available for quinoxalines and indomethacin

ArticleYear
Quinoxaline: An insight into the recent pharmacological advances.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Animals; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents; Antihypertensive Agents; Antineoplastic Agents; Humans; Quinoxalines

2018

Trials

1 trial(s) available for quinoxalines and indomethacin

ArticleYear
Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy.
    American journal of ophthalmology, 2002, Volume: 133, Issue:1

    Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Contrast Sensitivity; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Indomethacin; Intraocular Pressure; Laser-Doppler Flowmetry; Latanoprost; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Retinal Vessels; Visual Fields

2002

Other Studies

58 other study(ies) available for quinoxalines and indomethacin

ArticleYear
Studies on the effects of pharmacologic doses of cortisone acetate and several nonsteroidal anti-inflammatory compounds on ovo-implantation, early pregnancy, and the deciduomal response in the rat.
    Fertility and sterility, 1977, Volume: 28, Issue:4

    Topics: Animals; Cortisone; Decidua; Embryo Implantation; Embryonic Development; Estrone; Female; Flufenamic Acid; Indomethacin; Phenylbutazone; Pregnancy; Pregnancy, Animal; Progesterone; Quinoxalines; Rats

1977
Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed.
    The American journal of physiology, 1992, Volume: 262, Issue:3 Pt 2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cats; Dinoprost; GTP-Binding Proteins; Indomethacin; Methoxamine; Pertussis Toxin; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Quinoxalines; Signal Transduction; Thromboxane A2; Virulence Factors, Bordetella; Xanthines

1992
Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery.
    The Journal of physiology, 1992, Volume: 445

    Topics: Animals; Arginine; Bradykinin; Brimonidine Tartrate; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Isometric Contraction; Membrane Potentials; Nitroarginine; Quinoxalines; Thrombin; Vasodilation

1992
Serotonin is a directly-acting hyperalgesic agent in the rat.
    Neuroscience, 1992, Volume: 48, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Hydroxyurea; Hyperalgesia; Indomethacin; Male; Nociceptors; Oxidopamine; Pain; Quinoxalines; Rats; Rats, Inbred Strains; Reflex; Sensory Thresholds; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes

1992
Endogenous nitric oxide modulates adrenergic neural vasoconstriction in guinea-pig pulmonary artery.
    British journal of pharmacology, 1991, Volume: 104, Issue:2

    Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Electric Stimulation; Epoprostenol; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Pulmonary Artery; Quinoxalines; Receptors, Adrenergic; Sympathetic Nervous System; Vasoconstriction

1991
Cooling the central ear artery of the rabbit: myogenic and adrenergic responses.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 245, Issue:1

    Topics: Adenosine Triphosphate; Animals; Arteries; Brimonidine Tartrate; Calcium; Cold Temperature; Ear; Electric Stimulation; Indomethacin; Male; Norepinephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Tetrodotoxin; Vasoconstriction; Yohimbine

1988
Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:5

    Topics: Acetylcholine; Adenosine Diphosphate; Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Brimonidine Tartrate; Calcimycin; Dogs; Endothelium; Femoral Vein; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Quinoxalines; Thrombin

1987
Alpha 2-adrenergic receptors of the alpha 2c subtype mediate inhibition of norepinephrine release in human kidney cortex.
    Molecular pharmacology, 1994, Volume: 45, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Kidney Cortex; Norepinephrine; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha-2; Theophylline

1994
Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries.
    British journal of pharmacology, 1995, Volume: 116, Issue:8

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetonitriles; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arginine; Brimonidine Tartrate; Cyclooxygenase Inhibitors; Dopamine; Dopamine Antagonists; In Vitro Techniques; Indomethacin; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenoxybenzamine; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Rats; Rats, Wistar; Receptors, Dopamine; Serotonin Antagonists; Splanchnic Circulation; Thromboxane A2; Vasoconstrictor Agents

1995
Endothelium-dependent relaxation by alpha 2-adrenoceptor agonists in spontaneously hypertensive rat aorta.
    Journal of cardiovascular pharmacology, 1996, Volume: 27, Issue:5

    Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Endothelium, Vascular; Hypertension; Indomethacin; Nitroarginine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane A2; Vasodilation

1996
Glutathione causes coronary vasodilation via a nitric oxide- and soluble guanylate cyclase-dependent mechanism.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: Analysis of Variance; Animals; Blood Pressure; Carmustine; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Glyburide; Guanylate Cyclase; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Superoxide Dismutase; Vasodilation; Ventricular Function, Left

1997
Gender differences in endothelium-dependent relaxations do not involve NO in porcine coronary arteries.
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Calcimycin; Cholesterol; Coronary Vessels; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Lipoproteins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Ovariectomy; Progesterone; Prostaglandins; Quinoxalines; Sex Characteristics; Sexual Maturation; Swine; Testosterone

1997
Interaction of the renin-angiotensin system, bradykinin and sympathetic nerves with cholinergic transmission in the rat isolated trachea.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Brimonidine Tartrate; Epithelium; Female; Idazoxan; In Vitro Techniques; Indoles; Indomethacin; Male; Neprilysin; Nitroarginine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Renin-Angiotensin System; Sympathetic Nervous System; Trachea

1997
Involvement of bradykinin B1 and B2 receptors in relaxation of mouse isolated trachea.
    British journal of pharmacology, 1998, Volume: 123, Issue:7

    Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Dinoprostone; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Bradykinin; Trachea

1998
Characterization of temperature rise of the brain and the rectum following intracerebroventricular administration of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate and kainate in rats.
    Brain research, 1998, Jul-06, Volume: 798, Issue:1-2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics, Non-Narcotic; Animals; Body Temperature; Brain; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indomethacin; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Rectum

1998
Spreading depression induces expression of calcium-independent protein kinase C subspecies in ischaemia-sensitive cortical layers: regulation by N-methyl-D-aspartate receptors and glucocorticoids.
    Neuroscience, 1999, Volume: 93, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain Ischemia; Cortical Spreading Depression; Cyclooxygenase Inhibitors; Dexamethasone; Diclofenac; Disease Susceptibility; Dizocilpine Maleate; Enzyme Induction; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Enzymologic; Indomethacin; Isoenzymes; Male; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Parietal Lobe; Phospholipases A; Phospholipases A2; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Quinacrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcriptional Activation

1999
Pranidipine enhances relaxation produced by endothelium-derived relaxing factor in carotid artery.
    European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3

    Topics: Acetylcholine; Animals; Calcium Channel Blockers; Carotid Arteries; Dihydropyridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Norepinephrine; Oxadiazoles; Potassium; Quinoxalines; Vasoconstrictor Agents; Vasodilator Agents

1999
Evidence against potassium as an endothelium-derived hyperpolarizing factor in rat mesenteric small arteries.
    British journal of pharmacology, 2000, Volume: 129, Issue:3

    Topics: Acetylcholine; Animals; Barium Compounds; Chlorides; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Indomethacin; Isometric Contraction; Male; Mesenteric Arteries; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2000
Mechanisms of nitric oxide-independent relaxations induced by carbachol and acetylcholine in rat isolated renal arteries.
    British journal of pharmacology, 2000, Volume: 130, Issue:6

    Topics: Acetylcholine; Animals; Carbachol; Charybdotoxin; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indomethacin; Male; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ouabain; Oxadiazoles; Peptides; Phenylephrine; Potassium; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Artery; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation

2000
Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels.
    British journal of pharmacology, 2000, Volume: 130, Issue:8

    Topics: 4-Aminopyridine; Acetylcholine; Animals; Arachidonic Acids; Biological Factors; Cerebral Arteries; Charybdotoxin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Ouabain; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Vasodilation; Vasodilator Agents

2000
Inhibitory effect of valves on endothelium-dependent relaxations to calcium ionophore in canine saphenous vein.
    American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Calcium; Colforsin; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Indomethacin; Ionophores; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Potassium Chloride; Quinoxalines; Saphenous Vein; Vasoconstrictor Agents; Vasodilation

2001
Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats.
    British journal of pharmacology, 2001, Volume: 132, Issue:7

    Topics: Acetylcholine; Animals; Barium; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Glycyrrhetinic Acid; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Ouabain; Oxadiazoles; Potassium; Quinoxalines; Rats; Rats, Inbred WKY; Renal Artery; Vasodilation; Vasodilator Agents

2001
Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta.
    British journal of pharmacology, 2002, Volume: 135, Issue:1

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Hydrazones; In Vitro Techniques; Indomethacin; Male; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Thiophenes; Vasoconstriction; Vasodilator Agents

2002
Effect of NO on EDHF response in rat middle cerebral arteries.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:2

    Topics: Adenosine Triphosphate; Animals; Biological Factors; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Long-Evans; Thionucleotides; Vasodilation

2002
Carbon monoxide as a novel central pyrogenic mediator.
    Archives of pharmacal research, 2002, Volume: 25, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Body Temperature Regulation; Carbon Monoxide; Cerebrospinal Fluid; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Hemin; Hypothalamus; Indomethacin; Injections, Intraventricular; Male; Oxadiazoles; Protoporphyrins; Quinoxalines; Rats; Rats, Sprague-Dawley

2002
Rat retinal tissue releases a vasorelaxing factor.
    Investigative ophthalmology & visual science, 2002, Volume: 43, Issue:10

    Topics: Acute Disease; Animals; Calcium-Transporting ATPases; Carotid Arteries; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Retina; Sarcoplasmic Reticulum; Thapsigargin; Vasodilation; Vasodilator Agents

2002
Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Bridged-Ring Compounds; Brimonidine Tartrate; Buffers; Dose-Response Relationship, Drug; Heart; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Indomethacin; Male; Norbornanes; Norepinephrine; Perfusion; Presynaptic Terminals; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Thiocarbamates; Thiones; Yohimbine

2002
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery.
    British journal of pharmacology, 2003, Volume: 140, Issue:7

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Cardiovascular Agents; Catalase; Charybdotoxin; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Indomethacin; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Tetraethylammonium; Vasodilator Agents

2003
Evidence for the mechanisms underlying the effects of pimaradienoic acid isolated from the roots of Viguiera arenaria on rat aorta.
    Pharmacology, 2004, Volume: 70, Issue:1

    Topics: Animals; Aorta, Thoracic; Asteraceae; Brazil; Diterpenes; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethanol; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Oxadiazoles; Phenylephrine; Plant Extracts; Plant Roots; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasoconstriction; Vasodilation

2004
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
    Autonomic & autacoid pharmacology, 2003, Volume: 23, Issue:3

    Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide

2003
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
    British journal of pharmacology, 2004, Volume: 143, Issue:2

    Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Endocardium; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Hemodynamics; Hypertrophy, Left Ventricular; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium Channels; Quinoxalines; Swine; Vascular Resistance; Vasodilation

2004
Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:3

    Topics: Acetylcholine; Administration, Oral; Alcohol Drinking; Animals; Apamin; Atropine; Blood Pressure; Bradykinin; Brazil; Charybdotoxin; Clonidine; Deoxycholic Acid; Drug Therapy, Combination; Endothelium, Vascular; Flavonoids; Glyburide; Guanylate Cyclase; Hypertension; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Norepinephrine; Oxadiazoles; Perfusion; Phenols; Polyphenols; Potassium Chloride; Pressure; Pyrilamine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Wine; Yohimbine

2004
Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
    Pharmacology, 2004, Volume: 72, Issue:4

    Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cyclic GMP; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Hemoglobins; Hypertension, Renovascular; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Vasodilator Agents

2004
Endothelial mechanisms underlying responses to acetylcholine in the horse deep dorsal penile vein.
    European journal of pharmacology, 2005, May-16, Volume: 515, Issue:1-3

    Topics: Acetylcholine; Adenosine Triphosphate; Animals; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Horses; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Phenylephrine; Potassium; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Sodium Nitrite; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Veins

2005
Relaxant effect of adrenomedullin on bovine isolated iris sphincter muscle under resting conditions.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:8

    Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cattle; Dideoxyadenosine; Enzyme Inhibitors; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Nitroarginine; Oxadiazoles; Peptide Fragments; Peptides; Pupil; Quinoxalines; Signal Transduction

2005
Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:10

    Topics: Amides; Animals; Blotting, Western; Celiac Artery; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Guanine Nucleotide Exchange Factors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2005
Endothelium-independent flow-induced dilation in the mouse carotid artery.
    Journal of vascular research, 2006, Volume: 43, Issue:4

    Topics: Acetylcholine; Animals; Blood Flow Velocity; Carotid Arteries; Cyclooxygenase Inhibitors; Endothelium, Vascular; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Vasodilation; Vasodilator Agents

2006
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
    The American journal of Chinese medicine, 2006, Volume: 34, Issue:4

    Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil

2006
Vasorelaxant effects of icariin on isolated canine coronary artery.
    Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Dinoprost; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Female; Flavonoids; Glyburide; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Oxytocics; Potassium Channel Blockers; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Vasodilation

2007
Modulation of gap-junction-dependent arterial relaxation by ascorbic acid.
    Journal of vascular research, 2007, Volume: 44, Issue:5

    Topics: Animals; Ascorbic Acid; Boron Compounds; Connexin 43; Connexins; Dose-Response Relationship, Drug; Endothelium, Vascular; Gap Junction alpha-4 Protein; Gap Junction alpha-5 Protein; Gap Junctions; Hydrazines; Iliac Artery; Indoles; Indomethacin; Male; Membrane Potentials; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Nitroprusside; Oxadiazoles; Phenylephrine; Quinoxalines; Rabbits; Vasodilation

2007
Type 1 diabetes and hypercholesterolaemia reveal the contribution of endothelium-derived hyperpolarizing factor to endothelium-dependent relaxation of the rat aorta.
    Clinical and experimental pharmacology & physiology, 2008, Volume: 35, Issue:2

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Biological Factors; Blood Glucose; Body Weight; Charybdotoxin; Cholesterol; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hypercholesterolemia; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Oxidative Stress; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxides; Vasodilation; Vasodilator Agents

2008
Endothelial nitric oxide has inhibitory effects on rhythmic contractions in the aortas of sinoaortic deafferented rats.
    Journal of cardiovascular pharmacology, 2007, Volume: 50, Issue:5

    Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Autonomic Denervation; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxyhemoglobins; Phenylephrine; Quinoxalines; Rats

2007
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
    Vascular pharmacology, 2008, Volume: 48, Issue:1

    Topics: Acetylcholine; Amidohydrolases; Animals; Arginase; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin-1; Indomethacin; Lung Diseases; Male; Models, Biological; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasoconstriction

2008
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4

    Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Free Radical Scavengers; Guanylate Cyclase; Humans; Hydrogen Peroxide; Hydroquinones; In Vitro Techniques; Indomethacin; Mannitol; Mesenteric Artery, Superior; Methylene Blue; Muramidase; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Prostaglandins; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sepsis; Signal Transduction; Soluble Guanylyl Cyclase; Thionucleotides; Time Factors; Vasoconstrictor Agents; Vasodilation

2008
Endothelial nitric oxide attenuates Na+/Ca2+ exchanger-mediated vasoconstriction in rat aorta.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Aorta, Thoracic; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Potassium; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Calcium Exchanger; Thiourea; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents

2008
Pyritinol reduces nociception and oxidative stress in diabetic rats.
    European journal of pharmacology, 2008, Aug-20, Volume: 590, Issue:1-3

    Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Female; Indomethacin; Naltrexone; Oxadiazoles; Oxidative Stress; Pyrithioxin; Quinoxalines; Rats; Rats, Wistar; Streptozocin

2008
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
    Proceedings of the National Academy of Sciences of the United States of America, 2008, Dec-09, Volume: 105, Issue:49

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dopamine; Drug Interactions; Enzyme Inhibitors; Indomethacin; Interleukin-1beta; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Pyrrolidines; Quinoxalines; Rats; Rats, Wistar; Sensory Receptor Cells; Signal Transduction

2008
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.
    Natural product research, 2009, Volume: 23, Issue:2

    Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Oxadiazoles; Penis; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rabbits; Stephania tetrandra; Tetraethylammonium

2009
A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and N(G)-nitro-l-arginine hypertensive r
    Chemico-biological interactions, 2010, Jan-27, Volume: 183, Issue:2

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels, L-Type; Desoxycorticosterone; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypertension; Indomethacin; Male; Nitroarginine; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents

2010
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Aorta; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthalenes; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Prazosin; Propionates; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Thromboxane

2010
The lignan (-)-cubebin inhibits vascular contraction and induces relaxation via nitric oxide activation in isolated rat aorta.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:12

    Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Lignans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Piper; Quinoxalines; Rats; Rats, Wistar; Vasodilation

2013
Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2012, Volume: 95 Suppl 12

    Topics: Analysis of Variance; Animals; Aorta; Barium Compounds; Calcium Chloride; Chlorides; Endothelium, Vascular; Glyburide; Indomethacin; Male; Methoxamine; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasodilation; Vasodilator Agents; Xanthones

2012
An off-on COX-2-specific fluorescent probe: targeting the Golgi apparatus of cancer cells.
    Journal of the American Chemical Society, 2013, Aug-07, Volume: 135, Issue:31

    Topics: Acenaphthenes; Cell Line, Tumor; Cyclooxygenase 2; Fluorescent Dyes; Golgi Apparatus; Humans; Indomethacin; Models, Molecular; Neoplasms; Optical Imaging; Quinoxalines

2013
Underlying mechanisms involved in progesterone-induced relaxation to the pig bladder neck.
    European journal of pharmacology, 2014, Jan-15, Volume: 723

    Topics: Animals; Calcium; Cyclooxygenase Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Potassium; Potassium Channel Blockers; Potassium Channels; Progesterone; Quinoxalines; Receptors, Progesterone; Swine; Urinary Bladder; Urothelium

2014
The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats.
    European journal of pharmacology, 2014, May-15, Volume: 731

    Topics: Animals; Biological Factors; Electric Stimulation; Glyburide; Hemodynamics; Indomethacin; Male; Nitric Oxide; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Succinates; Sympathetic Nervous System; Synaptic Transmission

2014
A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.
    Pharmacological research, 2014, Volume: 90

    Topics: Animals; Bradykinin; Carbenoxolone; Catalase; Colforsin; Coronary Vessels; Female; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Ouabain; Oxadiazoles; Peptides; Polyethylene Glycols; Quinoxalines; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents; Vasodilation; Verapamil

2014
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells.
    British journal of pharmacology, 2016, Volume: 173, Issue:3

    Topics: Coculture Techniques; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelial Cells; Humans; Indomethacin; Myocytes, Smooth Muscle; Nitroarginine; Oxadiazoles; Quinoxalines; Receptors, G-Protein-Coupled; Receptors, Peptide; Recombinant Proteins; Relaxin; Signal Transduction; Umbilical Arteries; Umbilical Veins

2016
Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:5

    Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents

2018