Compounds > quinoxalines
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quinoxalines and idazoxan

quinoxalines has been researched along with idazoxan in 122 studies

Research

Studies (122)

TimeframeStudies, this research(%)All Research%
pre-199022 (18.03)18.7374
1990's76 (62.30)18.2507
2000's20 (16.39)29.6817
2010's4 (3.28)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paris, H; Remaury, A1
Buchholz, J; Duckles, SP; Friedman, D; Tsai, H1
Dieudonne, MN; Giudicelli, Y; Pecquery, R1
Berridge, TL; Doxey, JC; Roach, AG; Smith, CF1
Biegon, A; Budinger, TF; Mathis, CA1
Daviaud, D; Denis-Pouxviel, C; Devedjian, JC; Fargues, M; Paris, H; Prats, H1
Elliott, JM; Glue, P; Kay, G; Nutt, DJ; Payvandi, N1
Bültmann, R; Starke, K; von Kügelgen, I1
Arnsten, AF; Leslie, FM1
Bidet, M; Parini, A; Poujeol, P2
Atgie, C; Carpene, C; Lafontan, M; Quideau, N; Saulnier-Blache, JS1
Lafontan, M; Langin, D; Paris, H1
Dauzats, M; Lafontan, M; Langin, D; Paris, H1
Carpéné, C; Galitzky, J; Lafontan, M; Langin, D; Larrouy, D1
Carpéné, C; Dauzats, M; Lafontan, M; Larrouy, D; Quideau, N; Saulnier-Blache, JS1
Angel, I; Langer, SZ; Niddam, R1
Berlan, M; Galitzky, J; Lafontan, M; Montastruc, JL; Senard, JM; Stillings, M1
Doxey, JC; John, GW; Reid, JL; Walter, DS1
Dettmar, PW; Downing, OA; Roach, AG; Urquhart, CJ; Williams, RJ; Wilson, KA1
Carpéné, C; Guichard, C; Lafontan, M; Lavau, M; Rebourcet, MC1
Brandon, S; Cragoe, EJ; Guyer, CA; Horstman, DA; Limbird, LE; Wilson, AL1
Calvete, J; Hayes, R; Sever, PS; Thom, S1
Armstead, WM; Hyman, AL; Kadowitz, PJ; Lippton, HL1
Goldstein, M; Tsuda, K; Yokoo, H1
Galzin, AM; Langer, SZ; Ramdine, R1
Lacroix, JS; Lundberg, JM1
Angel, I; Taranger, MA1
Cattaneo, AG; Doxey, JC; Efendic, S; Ostenson, CG1
Carpéné, C; Lafontan, M; Langin, D; Saulnier-Blache, JS1
Downing, OA; Stein, W; Wilson, KA; Wilson, VG1
Calvete, J; Hayes, R; Martin, G; Sever, P; Thom, S1
Doxey, JC; Roach, AG; Samuel, J1
Hesse, IF; Johns, EJ1
Greenwood, B; Read, NW1
Dickinson, KE; McKernan, RM; Miles, CM; Sever, PS1
Dettmar, PW; Lord, JA1
Broadley, KJ; Williamson, KL1
Rhodes, KF; Waterfall, JF1
Convents, A; Convents, D; De Backer, JP; Vauquelin, G1
Goldstein, M; Schlesinger, DH; Yokoo, H1
Dooley, DJ; Hertting, G; Lupp, A; Osswald, H1
Kerry, R; Scrutton, MC1
Bradshaw, CM; Sheridan, RD; Szabadi, E1
Lester, BR; Sun, Z; Wilcox, GL; Wu, HH1
Advenier, C; Biyah, K1
Kemmotsu, O; Matsumoto, M; Numazawa, R; Saito, H; Togashi, H; Yoshioka, M1
Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG1
Bouloumie, A; Galitzky, J; Lafontan, M; Langin, D; Remaury, A; Tavernier, G; Valet, P1
Szabo, B; Urban, R1
Angel, I; Eon, MT; Langer, SZ; Lorrain, J; Oblin, A1
Cable, HC; el-Mansoury, A; Morgan, NG1
Gazzola, C; Hunter, RA; Lisle, AT; Magner, T1
García-Sevilla, JA; Garro, MA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L1
Robinson, NE; Wang, Z; Yu, M1
Musgrave, IF; Seifert, R1
Etgen, AM; Karkanias, GB1
García-Sevilla, JA; Sastre, M1
Numazawa, R1
Bouloumié, A; Devedjian, JC; Lafontan, M; Planat, V; Record, M; Saulnier-Blache, JS; Valet, P1
Fredholm, BB; Hu, PS1
Angel, I; Grosset, A; Langer, SZ; Perrault, G; Schoemaker, H1
Berlan, M; Galitzky, J; Le Corre, P; Le Verge, R1
Couvineau, A; Daviaud, D; Denis, C; Devedjian, JC; Drean, G; Planat, V; Salomon, R; Senard, JM; Valet, P; Voisin, T1
Daviaud, D; Larrouy, D; Paris, H; Remaury, A; Rouot, B1
Asier Garro, M; García-Sevilla, JA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L1
Buchholz, J; Duckles, SP; Tsai, H1
Reiner, PB; Williams, JA1
García-Sevilla, JA; Miralles, A; Ribas, C1
Starke, K; Trendelenburg, AU; Wahl, CA1
Bryan, RM; Childres, WF; Eichler, MY; Johnson, TD; Suresh, MS; Swafford, MW1
Bohmann, C; Rist, W; Rump, LC; Schollmeyer, P1
Berggren, PO; Efanov, AM; Efanova, IB; Efendić, S; Gold, G; Larsson, O; Ostenson, CG; Zaitsev, SV1
Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM1
Flügge, G1
Colpaert, F; Marien, M; Tellez, S1
Intengan, HD; Smyth, DD1
Autissier, N; Beltramo, JL; Ben Cheikh, R; Chomard, P; Dumas, P1
Bétuing, S; Daviaud, D; Hickson, G; Lafontan, M; Lapalu, S; Peyroulan, D; Saulnier-Blache, JS; Valet, P1
Furukawa, T; Morishita, H1
Coupar, IM; Liu, L1
Elliott, J1
Goldstein, I; Huang, YH; Moreland, RB; Traish, AM1
Correze, C; Dib, K; el Jamali, A; Lambert, B; Wrisez, F1
Dinh, DT; Fabiani, ME; Story, DF1
Callado, LF; García-Sevilla, JA; Grijalba, B; Meana, JJ; Pazos, A; Sastre, M1
Barbe, P; Daviaud, D; Jeanneton, O; Lafontan, M; Pagès, C; Record, M; Saulnier-Blache, JS; Valet, P1
Escribá, PV; García-Sevilla, JA; Miralles, A; Ribas, C1
Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L1
Chopin, P; Colpaert, FC; Marien, M1
Cayla, C; Gales, C; Paris, H; Quinchon, F; Roquelaine, C; Schaak, S1
Colpaert, FC; Pauwels, PJ; Wurch, T1
Bobirnac, I; Gazi, L; Loetscher, E; Parsley, S; Schoeffter, P1
Mateo, Y; Meana, JJ1
Cox, SL; Gaiser, EG; Meyer, A; Starke, K; Trendelenburg, AU1
Nott, MW; Rand, MJ; Thaina, P1
Hall, L; Hudson, AL; Jackson, HC; Nutt, DJ; Robinson, ES1
De Luca Júnior, LA; de Oliveira, LB; Menani, JV; Miguel, TT; Sugawara, AM1
Kawahara, H; Kawahara, Y; Westerink, BH1
Cockcroft, V; Frang, H; Marjamäki, A; Pihlavisto, M; Scheinin, M1
Bylund, DB; Happe, HK; Murrin, LC1
Colpaert, FC; Finana, F; Pauwels, PJ; Tardif, S; Wurch, T1
Bosch, F; Casellas, A; Cayla, C; Devedjian, JC; George, M; Paris, H; Pujol, A1
Iida, S; Ishihama, K; Kogo, M; Koizumi, H; Matsuya, T; Mori, A; Tanaka, S1
Colpaert, FC; Pauwels, PJ1
Allie, S; Russell, V; Wiggins, T1
Busquets, X; García-Sevilla, JA; Miralles, A; Ribas, C1
Bylund, DB; Gerety, ME; Happe, HK; Murrin, LC1
Bishai, JM; Buchholz, JN; Gheorghe, CP; Longo, LD; Meulenaar, R; Nijland, R; Penninga, L; Zhang, L; Zhao, Y1
Artigues-Varin, C; Mulder, P; Richard, V; Thuillez, C; Varin, R1
Pauwels, PJ; Rauly, I; Wurch, T1
Cistarelli, L; Di Cara, B; Gobert, A; Millan, MJ1
Birthelmer, A; Cassel, JC; Jackisch, R; Stemmelin, J1
Hoffrén, AM; Johnson, MS; Kanerva, L; Marjamäki, A; Nyrönen, T; Peltonen, JM; Pihlavisto, M; Savola, JM; Scheinin, M; Wurster, S; Xhaard, H1
Grandoso, L; Pineda, J; Torrecilla, M; Ugedo, L1
Freiman, TM; Heinemeyer, J; Klar, M; Kukolja, J; Surges, R; van Velthoven, V; Zentner, J1
Kolaj, M; Renaud, LP1
Bai, A; Chen, J; Guo, Y; Liu, Z; Lu, N1
Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P1
Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Takada, K; Uchida, T; Verheij, MM1
Álvarez de La Rosa, D; Arce-Franco, M; Armas-González, E; Barreiro, O; Díaz-González, F; Domínguez-Luis, MJ; Feria, M; Herrera-García, AM; Machado, JD; Pec, MK; Sánchez-Madrid, F1
Cassel, JC; Ferry, B; Lazarus, C; Marien, M; McGaugh, JL; Parrot, S1

Trials

1 trial(s) available for quinoxalines and idazoxan

ArticleYear
Human vascular smooth muscle responses mediated by alpha 2 mechanisms in vivo and in vitro.
    Clinical science (London, England : 1979), 1985, Volume: 68 Suppl 10

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Arteries; Brimonidine Tartrate; Dioxanes; Doxazosin; Forearm; Humans; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha

1985

Other Studies

121 other study(ies) available for quinoxalines and idazoxan

ArticleYear
The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:1

    Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Cell Line; Cyclic AMP; Dioxanes; GTP-Binding Proteins; Idazoxan; Immunoblotting; Insulin; Insulin Secretion; Kinetics; Membranes; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tritium; Virulence Factors, Bordetella; Yohimbine

1992
Influence of age on control of norepinephrine release from the rat tail artery.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2

    Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Norepinephrine; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Dopamine; Tail; Yohimbine

1992
Characteristics of the alpha 2/beta-adrenoceptor-coupled adenylate cyclase system and their relationship with adrenergic responsiveness in hamster fat cells from different anatomical sites.
    European journal of biochemistry, 1992, Apr-15, Volume: 205, Issue:2

    Topics: Adenylyl Cyclases; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Colforsin; Cricetinae; Dioxanes; Epididymis; Epinephrine; GTP-Binding Proteins; Idazoxan; Isoproterenol; Kinetics; Lipolysis; Macromolecular Substances; Male; Mesocricetus; Organ Specificity; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Skin; Theophylline

1992
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
    European journal of pharmacology, 1992, Mar-24, Volume: 213, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens

1992
Quantitative in vitro and ex vivo autoradiography of the alpha 2-adrenoceptor antagonist [3H]atipamezole.
    European journal of pharmacology, 1992, Nov-24, Volume: 224, Issue:1

    Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Animals; Autoradiography; Brain; Brimonidine Tartrate; Dioxanes; Humans; Idazoxan; Imidazoles; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tissue Distribution

1992
Regulation of the alpha 2A-adrenergic receptor in the HT29 cell line. Effects of insulin and growth factors.
    The Journal of biological chemistry, 1991, Aug-05, Volume: 266, Issue:22

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding Sites; Blotting, Northern; Brimonidine Tartrate; Cyclic AMP; Dioxanes; Flow Cytometry; Glycolysis; Growth Substances; Humans; Idazoxan; Insulin; Kinetics; Nucleic Acid Hybridization; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Tumor Cells, Cultured

1991
Effects of chronic alpha 2-adrenoceptor blockade on platelet and lymphocyte adrenoceptor binding in normal volunteers.
    Life sciences, 1991, Volume: 49, Issue:8

    Topics: Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Humans; Idazoxan; Lymphocytes; Male; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Up-Regulation; Yohimbine

1991
Contraction-mediating alpha 2-adrenoceptors in the mouse vas deferens.
    Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:6

    Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Drug Interactions; Idazoxan; Male; Mice; Muscle Contraction; Neuropeptide Y; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Suramin; Vas Deferens; Yohimbine

1991
Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.
    Neuropharmacology, 1991, Volume: 30, Issue:12A

    Topics: Adrenergic alpha-Agonists; Animals; Azepines; Behavior, Animal; Blood Pressure; Brain; Brimonidine Tartrate; Cognition; Dioxanes; Female; Guanfacine; Hypnotics and Sedatives; Idazoxan; Macaca mulatta; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical; Yohimbine

1991
The imidazoline-guanidinium receptor site, a target for some alpha-2 adrenergic agonists, is involved in inhibition of Na(+)-H+ exchange in renal proximal tubule cells.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1991, Volume: 9, Issue:6

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Carrier Proteins; Dioxanes; Hydrogen; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ion Exchange; Kidney Tubules, Proximal; Oxazoles; Quinoxalines; Rabbits; Receptors, Drug; Rilmenidine; Sodium; Sodium-Hydrogen Exchangers

1991
Hamster adipocyte alpha 2-adrenoceptor changes during fat mass modifications are not directly dependent on adipose tissue norepinephrine content.
    Endocrinology, 1990, Volume: 126, Issue:5

    Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cricetinae; Dioxanes; Energy Intake; Food Deprivation; Hydroxydopamines; Idazoxan; Lipolysis; Male; Mesocricetus; Norepinephrine; Oxidopamine; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha; Sympathectomy, Chemical

1990
Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites.
    Molecular pharmacology, 1990, Volume: 37, Issue:6

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Binding Sites; Brimonidine Tartrate; Cell Membrane; Cystamine; Dioxanes; Dioxins; Epinephrine; Female; Humans; Idazoxan; Magnesium Chloride; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Tritium; Yohimbine

1990
Discrimination between alpha 2-adrenoceptors and [3H]idazoxan-labelled non-adrenergic sites in rabbit white fat cells.
    European journal of pharmacology, 1990, Apr-25, Volume: 188, Issue:4-5

    Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Dioxanes; Dioxins; Epinephrine; Idazoxan; In Vitro Techniques; Kinetics; Lipolysis; Male; Quinoxalines; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug; Structure-Activity Relationship

1990
Non-adrenergic sites for imidazolines are not directly involved in the alpha 2-adrenergic antilipolytic effect of UK 14304 in rat adipocytes.
    Biochemical pharmacology, 1990, Aug-01, Volume: 40, Issue:3

    Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Bucladesine; Cell Membrane; Colforsin; Dioxanes; Idazoxan; Kinetics; Lipolysis; Phentolamine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine

1990
Photoperiodic control of adipocyte alpha 2-adrenoceptors in Syrian hamsters: role of testosterone.
    Endocrinology, 1990, Volume: 127, Issue:3

    Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Cricetinae; Dioxanes; Idazoxan; Isoproterenol; Kidney; Light; Lipolysis; Male; Mesocricetus; Periodicity; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha; Testosterone

1990
Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Dioxanes; Dioxins; Drug Interactions; Hyperglycemia; Idazoxan; Imidazoles; Insulin; Male; Mice; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha

1990
Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan.
    British journal of pharmacology, 1990, Volume: 100, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Oxymetazoline; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine

1990
Selective alpha 2-adrenoceptor blockade does not enhance glucose-evoked insulin release.
    European journal of pharmacology, 1990, Oct-23, Volume: 187, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Dioxanes; Drug Interactions; Glucose; Idazoxan; Insulin; Male; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains

1990
Alpha 2-adrenoceptor antisecretory responses in the rat jejunum.
    Journal of autonomic pharmacology, 1990, Volume: 10, Issue:2

    Topics: Animals; Body Fluids; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Electrolytes; Idazoxan; In Vitro Techniques; Jejunum; Male; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetrodotoxin; Theophylline

1990
Increased alpha 2-adrenergic binding sites and antilipolytic effect in adipocytes from genetically obese rats.
    Journal of lipid research, 1990, Volume: 31, Issue:5

    Topics: Adipose Tissue; Animals; Binding Sites; Brimonidine Tartrate; Dioxanes; Epinephrine; Idazoxan; Kinetics; Lipolysis; Male; Obesity; Propranolol; Quinoxalines; Rats; Rats, Zucker; Receptors, Adrenergic, alpha

1990
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.
    The Journal of biological chemistry, 1990, Dec-15, Volume: 265, Issue:35

    Topics: Affinity Labels; Allosteric Regulation; Amino Acid Sequence; Animals; Aspartic Acid; Brimonidine Tartrate; Dioxanes; DNA Mutational Analysis; Epinephrine; Idazoxan; In Vitro Techniques; Molecular Sequence Data; Oxymetazoline; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Sodium; Structure-Activity Relationship; Swine; Transfection; Yohimbine

1990
Effect of imidazolines on Na+ transport and intracellular pH in renal proximal tubule cells.
    Biochimica et biophysica acta, 1990, May-09, Volume: 1024, Issue:1

    Topics: Amiloride; Animals; Biological Transport; Brimonidine Tartrate; Cimetidine; Dioxanes; Dioxins; Hydrogen-Ion Concentration; Idazoxan; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sodium

1990
In vivo and in vitro studies of alpha 2-adrenoceptor responses in human vascular smooth muscle.
    Journal of cardiovascular pharmacology, 1985, Volume: 7 Suppl 6

    Topics: Adult; Animals; Arm; Brimonidine Tartrate; Dioxanes; Dioxins; Doxazosin; Epinephrine; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Vasomotor System

1985
Influence of nisoldipine on vascular resistance and vasoconstrictor responses in cats.
    The American journal of physiology, 1987, Volume: 252, Issue:4 Pt 2

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Azepines; Blood Pressure; Brimonidine Tartrate; Cardiac Output; Cats; Dinoprost; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Methoxamine; Nifedipine; Nisoldipine; Norepinephrine; Phenylephrine; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Quinoxalines; Splanchnic Circulation; Sulfonamides; Sympathetic Nervous System; Tyramine; Vascular Resistance; Vasoconstriction

1987
Neuropeptide Y and galanin in norepinephrine release in hypothalamic slices.
    Hypertension (Dallas, Tex. : 1979), 1989, Volume: 14, Issue:1

    Topics: Adenylate Cyclase Toxin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Galanin; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Neuropeptide Y; Norepinephrine; Peptides; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella

1989
Involvement of adenylate cyclase and protein kinase C in the alpha 2-adrenoceptor-mediated inhibition of noradrenaline and 5-hydroxytryptamine release in rat hypothalamic slices.
    Naunyn-Schmiedeberg's archives of pharmacology, 1989, Volume: 340, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Antihypertensive Agents; Brimonidine Tartrate; Colforsin; Dioxanes; Electric Stimulation; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin

1989
Sympathetic vascular control of the pig nasal mucosa: adrenoceptor mechanisms in blood flow and volume control.
    British journal of pharmacology, 1989, Volume: 97, Issue:4

    Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Desipramine; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Nasal Mucosa; Norepinephrine; Oxymetazoline; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic; Regional Blood Flow; Rheology; Swine; Sympathetic Nervous System

1989
Coupling between hypothalamic alpha 2-adrenoceptors and [3H]mazindol binding site in response to several hyperglycaemic stimuli in mice.
    Brain research, 1989, Jun-26, Volume: 490, Issue:2

    Topics: Animals; Binding Sites; Brimonidine Tartrate; Dioxanes; Feeding Behavior; Hyperglycemia; Hypothalamus; Idazoxan; Indoles; Male; Mazindol; Mice; Quinoxalines; Receptors, Adrenergic, alpha

1989
Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats.
    The American journal of physiology, 1989, Volume: 257, Issue:3 Pt 1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Diabetes Mellitus, Experimental; Dioxanes; Female; Glucose; Idazoxan; Insulin; Islets of Langerhans; Male; Phentolamine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Streptozocin; Yohimbine

1989
Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors.
    European journal of pharmacology, 1989, Nov-21, Volume: 171, Issue:2-3

    Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cricetinae; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipolysis; Male; Mesocricetus; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine

1989
A comparison of the actions of noradrenaline and UK-14,304 in the longitudinal smooth muscle of the rat isolated portal vein--no evidence for a population of post-junctional alpha 2-adrenoceptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 338, Issue:3

    Topics: Animals; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha

1988
Effects of desipramine on stimulation-induced contractions of the vas deferens of rats pretreated either chronically with desipramine or acutely with idazoxan.
    Clinical science (London, England : 1979), 1985, Volume: 68 Suppl 10

    Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Desipramine; Dioxanes; Dioxins; Drug Interactions; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors; Vas Deferens

1985
The role of alpha-adrenoceptors in the regulation of renal tubular sodium reabsorption and renin secretion in the rabbit.
    British journal of pharmacology, 1985, Volume: 84, Issue:3

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Guanabenz; Hemodynamics; Idazoxan; Kidney; Kidney Tubules; Male; Methoxamine; Natriuresis; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Renin; Sodium

1985
Neural control of jejunal and ileal motility and transmural potential difference in the ferret.
    Canadian journal of physiology and pharmacology, 1986, Volume: 64, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Brimonidine Tartrate; Dioxanes; Ferrets; Gastrointestinal Motility; Idazoxan; Ileum; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Muscle Contraction; Quinoxalines

1986
Heterogeneity between soluble human and rabbit splenic alpha 2-adrenoceptors.
    Biochemical pharmacology, 1986, Oct-15, Volume: 35, Issue:20

    Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; Lectins; Oxymetazoline; Phentolamine; Prazosin; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Solubility; Spleen; Sulfhydryl Reagents; Yohimbine

1986
The effect of alpha 2-adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation.
    British journal of pharmacology, 1986, Volume: 89, Issue:2

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Gastric Acid; Gastric Mucosa; Histamine; Idazoxan; In Vitro Techniques; Male; Pentagastrin; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains

1986
Characterization of the alpha-adrenoceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists.
    Archives internationales de pharmacodynamie et de therapie, 1987, Volume: 285, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Myocardial Contraction; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical

1987
The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine.
    Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Dioxanes; Dogs; Idazoxan; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Quinoxalines; Saphenous Vein

1987
Tight agonist binding may prevent the correct interpretation of agonist competition binding curves for alpha 2-adrenergic receptors.
    Molecular pharmacology, 1987, Volume: 32, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cell Membrane; Clonidine; Dioxanes; Epinephrine; Idazoxan; Kinetics; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Retina

1987
The effect of neuropeptide Y (NPY) on stimulation-evoked release of [3H]norepinephrine (NE) from rat hypothalamic and cerebral cortical slices.
    European journal of pharmacology, 1987, Nov-10, Volume: 143, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Neuropeptide Y; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Stimulation, Chemical

1987
Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release.
    European journal of pharmacology, 1988, Mar-29, Volume: 148, Issue:2

    Topics: Aminopyridines; Animals; Brimonidine Tartrate; Cadmium; Calcium Channel Blockers; Dioxanes; Hippocampus; Idazoxan; In Vitro Techniques; Mollusk Venoms; Neomycin; Nicotinic Acids; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Phorbol Esters; Quinoxalines; Rabbits

1988
Effect of 781094, a new selective alpha-adrenoceptor antagonist, on the aggregatory responses of human blood platelets and on binding of [3H]-dihydroergocryptine to these cells.
    British journal of pharmacology, 1983, Volume: 79, Issue:2

    Topics: Adrenergic alpha-Antagonists; Blood Platelets; Brimonidine Tartrate; Clonidine; Dihydroergotoxine; Dioxins; Epinephrine; Humans; Idazoxan; Methoxamine; Platelet Aggregation; Quinoxalines; Serotonin; Tritium

1983
Neuronal responses to noradrenaline in the cerebral cortex: evidence against the involvement of alpha 2-adrenoceptors.
    British journal of pharmacology, 1984, Volume: 82, Issue:2

    Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Idazoxan; Male; Neurons; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine

1984
Antinociception following implantation of mouse B16 melanoma cells in mouse and rat spinal cord.
    Pain, 1994, Volume: 56, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Catecholamines; Cell Transplantation; Desipramine; Dioxanes; Idazoxan; Injections, Spinal; Male; Melanoma, Experimental; Mice; Mice, Inbred ICR; Morphine; Naloxone; Neoplasm Transplantation; Nociceptors; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P; Transplantation, Heterotopic

1994
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
    Neuropeptides, 1995, Volume: 28, Issue:4

    Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea

1995
Pharmacological characterization of alpha 2-adrenoceptor regulated serotonin release in the rat hippocampus.
    Neuroscience letters, 1995, Jun-16, Volume: 192, Issue:3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Dioxanes; GTP-Binding Proteins; Hippocampus; Idazoxan; Imidazoles; Male; Oxidopamine; Pertussis Toxin; Potassium; Quinoxalines; Rats; Rats, Wistar; Second Messenger Systems; Serotonin; Tetrodotoxin; Virulence Factors, Bordetella

1995
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
    British journal of pharmacology, 1995, Volume: 115, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine

1995
Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 1

    Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Base Sequence; Brimonidine Tartrate; Bucladesine; Catecholamines; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dioxanes; DNA Primers; Epididymis; Gene Expression; Idazoxan; Isoproterenol; Lipase; Lipolysis; Male; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Propanolamines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA, Messenger; Skin

1995
Mechanism of sympathoinhibition by imidazolines.
    Annals of the New York Academy of Sciences, 1995, Jul-12, Volume: 763

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine

1995
Inhibition of insulin release induced by galanin in the dog is not exclusively mediated by activation of ATP-sensitive K+ channels.
    Pharmacology, 1993, Volume: 46, Issue:2

    Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Diazoxide; Dioxanes; Dogs; Female; Galanin; Ganglia, Sympathetic; Glyburide; Idazoxan; Insulin; Insulin Secretion; Male; Norepinephrine; Pancreas; Peptides; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha; Sensitivity and Specificity

1993
Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.
    The Biochemical journal, 1995, Apr-01, Volume: 307 ( Pt 1)

    Topics: Actins; Adenoma, Islet Cell; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Biopolymers; Brimonidine Tartrate; Cytochalasins; Dioxanes; Drug Interactions; Exocytosis; Fluorescent Dyes; Gene Expression Regulation; Idazoxan; Insulin; Insulin Secretion; Islets of Langerhans; Neoplasm Proteins; Norepinephrine; Pertussis Toxin; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured; Virulence Factors, Bordetella

1995
Effects of alpha-adrenoceptor agonists and antagonists on metabolic rate in cattle.
    Comparative biochemistry and physiology. Part A, Physiology, 1995, Volume: 111, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basal Metabolism; Body Temperature; Brimonidine Tartrate; Cattle; Clonidine; Dioxanes; Female; Guanfacine; Heart Rate; Idazoxan; Male; Prazosin; Quinoxalines

1995
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors.
    European journal of pharmacology, 1993, Aug-03, Volume: 239, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Clonidine; Dihydroxyphenylalanine; Dioxanes; Idazoxan; Injections, Subcutaneous; Male; Mydriasis; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reserpine; Tyrosine 3-Monooxygenase; Vas Deferens

1993
Prejunctional alpha 2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways.
    The American journal of physiology, 1993, Volume: 265, Issue:6 Pt 1

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Trachea; Yohimbine

1993
Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors.
    Biochemical pharmacology, 1994, Jan-20, Volume: 47, Issue:2

    Topics: Adrenergic alpha-Agonists; Azepines; Brimonidine Tartrate; Dioxanes; GTP Phosphohydrolases; Humans; Idazoxan; Isoproterenol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinoxalines; Receptors, Adrenergic, alpha; Superoxides; Tritium; Tumor Cells, Cultured

1994
Estradiol reduction of the agonist high affinity form of the alpha 2-adrenoceptor in the hypothalamus of female rats: identification as the alpha 2D subtype.
    Molecular pharmacology, 1994, Volume: 45, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Dioxanes; Estradiol; Female; Hypothalamus; Idazoxan; Kinetics; Preoptic Area; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2

1994
Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Brain Chemistry; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Dioxanes; Female; GTP-Binding Proteins; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2

1994
[Pharmacological characterization of alpha 2-adrenoceptor regulated 5-HT release in the rat hippocampus].
    [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1994, Volume: 69, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hippocampus; Idazoxan; Microdialysis; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin

1994
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
    The Journal of biological chemistry, 1994, Dec-02, Volume: 269, Issue:48

    Topics: 3T3 Cells; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Clone Cells; Clonidine; Cyclic AMP; Dioxanes; Humans; Idazoxan; Kinetics; Male; Mice; Pertussis Toxin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection; Virulence Factors, Bordetella

1994
Effect of an intracellular calcium chelator on the regulation of electrically evoked [3H]-noradrenaline release from rat hippocampal slices.
    British journal of pharmacology, 1993, Volume: 108, Issue:1

    Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Chelating Agents; Dioxanes; Egtazic Acid; Electric Stimulation; Hippocampus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; omega-Conotoxins; Peptides, Cyclic; Quinoxalines; Rats; Rats, Sprague-Dawley

1993
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist.
    European journal of pharmacology, 1993, Apr-06, Volume: 234, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Epinephrine; Heart Rate; Hyperglycemia; Idazoxan; Indoles; Male; Mice; Motor Activity; Norepinephrine; Peripheral Nerves; Prazosin; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasoconstriction

1993
Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine.
    British journal of pharmacology, 1993, Volume: 108, Issue:4

    Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Platelets; Blood Proteins; Brimonidine Tartrate; Cell Membrane; Dioxanes; Epinephrine; Humans; Hydroxylation; Idazoxan; In Vitro Techniques; Lipolysis; Male; Platelet Aggregation; Protein Binding; Quinoxalines; Yohimbine

1993
Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.
    The Journal of clinical investigation, 1993, Volume: 91, Issue:5

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cell Membrane; Colon; Dioxanes; Duodenum; Epinephrine; Epithelium; Humans; Idazoxan; Intestinal Mucosa; Kinetics; Microvilli; NAD; Organ Specificity; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Virulence Factors, Bordetella

1993
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.
    The Biochemical journal, 1993, May-15, Volume: 292 ( Pt 1)

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dioxanes; GTP-Binding Proteins; Humans; Idazoxan; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella

1993
Acute and chronic effects of cholinesterase inhibitors and pilocarpine on the density and sensitivity of central and peripheral alpha 2-adrenoceptors.
    European journal of pharmacology, 1993, Jun-04, Volume: 236, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Cholinesterase Inhibitors; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Isoflurophate; Male; Neostigmine; Physostigmine; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase; Vas Deferens

1993
Postjunctional alpha 2-adrenoceptors in blood vessels: effect of age.
    European journal of pharmacology, 1993, Jun-24, Volume: 237, Issue:2-3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Methoxamine; Norepinephrine; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha; Tail; Vasoconstriction; Yohimbine

1993
Noradrenaline hyperpolarizes identified rat mesopontine cholinergic neurons in vitro.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1993, Volume: 13, Issue:9

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biomarkers; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Lysine; NADPH Dehydrogenase; Neurons; Norepinephrine; Pons; Potassium Channels; Quinoxalines; Rats; Receptors, Adrenergic, alpha

1993
Acceleration by chronic treatment with clorgyline of the turnover of brain alpha 2-adrenoceptors in normotensive but not in spontaneously hypertensive rats.
    British journal of pharmacology, 1993, Volume: 110, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brimonidine Tartrate; Cerebral Cortex; Clorgyline; Dioxanes; Down-Regulation; Hypertension; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Quinolines; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Species Specificity

1993
Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1996, Volume: 353, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Benzofurans; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Imidazoles; Isotope Labeling; Male; Norepinephrine; Oxathiins; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tritium

1996
Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery.
    Anesthesiology, 1996, Volume: 85, Issue:1

    Topics: Animals; Arginine; Brimonidine Tartrate; Cerebral Arteries; Cerebrovascular Circulation; Dioxanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Idazoxan; Imidazoles; Male; NG-Nitroarginine Methyl Ester; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Vasodilation

1996
Low concentrations of angiotensin II unmask vasoconstrictory alpha 2-adrenoceptors in isolated perfused kidneys of spontaneously hypertensive rats.
    Cardiovascular research, 1995, Volume: 30, Issue:6

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Brimonidine Tartrate; Dioxanes; Dose-Response Relationship, Drug; Hypertension; Idazoxan; Imidazoles; Kidney; Methoxamine; Perfusion; Prazosin; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction

1995
Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.
    Diabetes, 1996, Volume: 45, Issue:11

    Topics: Animals; Brimonidine Tartrate; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diazoxide; Exocytosis; Glucose; Idazoxan; Imidazoles; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Phentolamine; Potassium Channels; Potassium Chloride; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Tumor Cells, Cultured

1996
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine

1996
Alterations in the central nervous alpha 2-adrenoceptor system under chronic psychosocial stress.
    Neuroscience, 1996, Volume: 75, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Chronic Disease; Down-Regulation; Hydrocortisone; Idazoxan; Locus Coeruleus; Male; Nerve Tissue Proteins; Norepinephrine; Oxymetazoline; Pituitary-Adrenal System; Prefrontal Cortex; Quinoxalines; Receptors, Adrenergic, alpha-2; Social Dominance; Solitary Nucleus; Stress, Psychological; Tupaiidae; Up-Regulation; Vagus Nerve

1996
Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists.
    Journal of neurochemistry, 1997, Volume: 68, Issue:2

    Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Guanabenz; Idazoxan; Imidazoles; Male; Microdialysis; Piperoxan; Prefrontal Cortex; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley

1997
Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Body Water; Brimonidine Tartrate; Guanfacine; Idazoxan; Kidney; Male; Naltrexone; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2

1997
Influence of prolonged fasting and thyroid hormone on the alpha 2-adrenergic response in isolated epididymal adipocytes of Wistar rats.
    European journal of endocrinology, 1997, Volume: 136, Issue:2

    Topics: Adipocytes; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Separation; Epididymis; Fasting; Idazoxan; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Time Factors; Triiodothyronine

1997
Functional consequences of constitutively active alpha2A-adrenergic receptor expression in 3T3F442A preadipocytes and adipocytes.
    Biochemical and biophysical research communications, 1997, Jun-27, Volume: 235, Issue:3

    Topics: 3T3 Cells; Adipocytes; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Culture Media, Serum-Free; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Idazoxan; Kinetics; Lipolysis; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Sodium Chloride; Transfection

1997
Existence of dopamine D1 receptor on the sympathetic nerve endings in the guinea-pig vas deferens.
    European journal of pharmacology, 1997, Jun-11, Volume: 328, Issue:2-3

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Guinea Pigs; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Presynaptic Terminals; Quinoxalines; Receptors, Dopamine D1; Spiperone; Synaptic Transmission; Vas Deferens

1997
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
    Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 356, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic

1997
Alpha-adrenoceptors in equine digital veins: evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction.
    Journal of veterinary pharmacology and therapeutics, 1997, Volume: 20, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Dopamine; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Veins; Yohimbine

1997
Expression of functional alpha2-adrenergic receptor subtypes in human corpus cavernosum and in cultured trabecular smooth muscle cells.
    Receptors & signal transduction, 1997, Volume: 7, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Penis; Quinoxalines; Radioisotopes; Receptors, Adrenergic, alpha-2; Ribonucleases; RNA, Messenger; Yohimbine

1997
Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells.
    Cellular signalling, 1997, Volume: 9, Issue:6

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adrenergic alpha-Agonists; Animals; Astrocytes; Brimonidine Tartrate; Carcinogens; Cell Fractionation; Cell Membrane; Cerebral Cortex; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Idazoxan; Male; Pertussis Toxin; Phenylisopropyladenosine; Quinoxalines; Rats; Rats, Wistar; Saccharin; Signal Transduction; Swine; Taste; Thyroid Gland; Virulence Factors, Bordetella

1997
Interaction of the renin-angiotensin system, bradykinin and sympathetic nerves with cholinergic transmission in the rat isolated trachea.
    British journal of pharmacology, 1997, Volume: 122, Issue:6

    Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Brimonidine Tartrate; Epithelium; Female; Idazoxan; In Vitro Techniques; Indoles; Indomethacin; Male; Neprilysin; Nitroarginine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Renin-Angiotensin System; Sympathetic Nervous System; Trachea

1997
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.
    Journal of neurochemistry, 1998, Volume: 70, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding, Competitive; Brain Chemistry; Brimonidine Tartrate; Cell Membrane; Clonidine; Depression; Female; Frontal Lobe; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Suicide; Tritium

1998
Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.
    The Journal of clinical investigation, 1998, Apr-01, Volume: 101, Issue:7

    Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Adipocytes; Adult; Animals; Brimonidine Tartrate; Cell Differentiation; Cell Division; Cells, Cultured; Culture Techniques; Female; Humans; Idazoxan; Lysophospholipids; Mice; Paracrine Communication; Quinoxalines; Receptors, Adrenergic, alpha-2

1998
Effects of the alkylating agent EEDQ on regulatory G proteins and recovery of agonist and antagonist alpha2-adrenoceptor binding sites in rat brain.
    European journal of pharmacology, 1998, Jun-12, Volume: 351, Issue:1

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Brimonidine Tartrate; Cerebral Cortex; GTP-Binding Proteins; Idazoxan; Male; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley

1998
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 358, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine

1998
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra

1999
Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2.
    British journal of pharmacology, 1999, Volume: 126, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Carcinoma, Hepatocellular; Humans; Idazoxan; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tritium; Tumor Cells, Cultured

1999
G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors.
    British journal of pharmacology, 1999, Volume: 126, Issue:4

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; COS Cells; GTP-Binding Proteins; Humans; Idazoxan; Inositol Phosphates; Mice; Mutation; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship

1999
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
    European journal of pharmacology, 1999, May-07, Volume: 372, Issue:1

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Humans; Idazoxan; Isoquinolines; Neuroblastoma; Oxymetazoline; Piperazines; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Yohimbine

1999
Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo.
    European journal of pharmacology, 1999, Aug-20, Volume: 379, Issue:1

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Brimonidine Tartrate; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Dendritic Cells; Drug Interactions; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Time Factors

1999
Noradrenaline release from cultured mouse postganglionic sympathetic neurons: autoreceptor-mediated modulation.
    Journal of neurochemistry, 1999, Volume: 73, Issue:4

    Topics: Adenosine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Electric Stimulation; Ganglia, Sympathetic; Humans; Idazoxan; Kinetics; Mice; Mice, Inbred Strains; Neurons; Norepinephrine; Phenethylamines; Phentolamine; Purinergic P1 Receptor Agonists; Quinoxalines; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine

1999
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
    Journal of autonomic pharmacology, 1999, Volume: 19, Issue:3

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Stimulation; Female; Heart Atria; Heart Rate; Idazoxan; Imidazoles; In Vitro Techniques; Muscle Contraction; Norepinephrine; Pargyline; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors

1999
Autoradiographical and behavioural effects of a chronic infusion of antisense to the alpha2D-adrenoceptor in the rat.
    British journal of pharmacology, 1999, Volume: 128, Issue:3

    Topics: Animals; Autoradiography; Base Sequence; Behavior, Animal; Body Temperature; Brain; Brimonidine Tartrate; Idazoxan; Injections, Intraventricular; Male; Pupil; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Antisense

1999
Noradrenaline and mixed alpha 2-adrenoceptor/imidazoline-receptor ligands: effects on sodium intake.
    Brain research, 1999, Aug-28, Volume: 839, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Appetite; Behavior, Animal; Brimonidine Tartrate; Dehydration; Drinking; Eating; Food Deprivation; Guanabenz; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Ligands; Male; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Satiation; Sodium, Dietary

1999
The role of afferents to the locus coeruleus in the handling stress-induced increase in the release of noradrenaline in the medial prefrontal cortex: a dual-probe microdialysis study in the rat brain.
    European journal of pharmacology, 2000, Jan-17, Volume: 387, Issue:3

    Topics: Animals; Benzylamines; Bicuculline; Idazoxan; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Phosphinic Acids; Piperazines; Prefrontal Cortex; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Corticotropin-Releasing Hormone; Receptors, GABA; Receptors, Glutamate; Stress, Physiological

2000
Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.
    Journal of neurochemistry, 2000, Volume: 74, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Humans; Idazoxan; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Serine; Transfection; Tritium; Yohimbine

2000
Alpha(2)-adrenoceptor-stimulated GTP gamma S binding in rat brain: an autoradiographic study.
    European journal of pharmacology, 2000, Jun-30, Volume: 399, Issue:1

    Topics: Animals; Autoradiography; Brain; Brimonidine Tartrate; Dose-Response Relationship, Drug; Epinephrine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Serotonin

2000
Agonist efficacy at the alpha2A-adrenoceptor:G alpha15 fusion protein: an analysis based on Ca2+ responses.
    Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:6

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; CHO Cells; Cricetinae; Epinephrine; Fluorescent Dyes; GTP-Binding Proteins; Humans; Idazoxan; Ligands; Mice; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Signal Transduction; Transfection

2000
Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis.
    Diabetologia, 2000, Volume: 43, Issue:7

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Heterozygote; Homeostasis; Humans; Idazoxan; Immunohistochemistry; Insulin; Islets of Langerhans; Mice; Mice, Transgenic; Promoter Regions, Genetic; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction

2000
Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats.
    Brain research bulletin, 2000, Sep-15, Volume: 53, Issue:2

    Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Bicuculline; Brimonidine Tartrate; Idazoxan; Mastication; Motor Neurons; N-Methylaspartate; Neural Pathways; Norepinephrine; Organ Culture Techniques; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Trigeminal Nuclei

2000
Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Calcium; CHO Cells; Clonidine; Cricetinae; DNA, Recombinant; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Idazoxan; Kinetics; Medetomidine; Mice; Oxymetazoline; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Transfection

2000
Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat.
    Behavioural brain research, 2000, Dec-20, Volume: 117, Issue:1-2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Brimonidine Tartrate; Disease Models, Animal; Dopamine; Down-Regulation; Hypertension; Idazoxan; In Vitro Techniques; Male; Models, Neurological; Norepinephrine; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Long-Evans; Receptors, Adrenergic, alpha-2

2000
Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA.
    British journal of pharmacology, 2001, Volume: 132, Issue:7

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Gene Expression Regulation; GTP-Binding Proteins; Idazoxan; Male; Membranes; Norepinephrine; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reserpine; RNA, Messenger; Tritium

2001
A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain.
    Journal of neuroscience methods, 2001, Feb-15, Volume: 105, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; GTP-Binding Proteins; Guanosine Triphosphate; Idazoxan; Microtomy; Nucleotides; Protein Binding; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium

2001
Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:6

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Animals; Binding, Competitive; Brimonidine Tartrate; Cerebral Arteries; Clonidine; Dose-Response Relationship, Drug; Female; Fetus; Idazoxan; Middle Cerebral Artery; Norepinephrine; Phenylephrine; Pregnancy; Quinoxalines; Receptors, Adrenergic, alpha-2; Sheep; Tetrodotoxin; Vasoconstriction; Vasoconstrictor Agents; Yohimbine

2002
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
    Fundamental & clinical pharmacology, 2002, Volume: 16, Issue:4

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Azepines; Brimonidine Tartrate; Clonidine; Idazoxan; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxazoles; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Yohimbine

2002
Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Benzopyrans; Binding Sites; Brimonidine Tartrate; CHO Cells; Cricetinae; Cyclic AMP; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Idazoxan; Imidazoles; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Sulfur Radioisotopes; Tumor Cells, Cultured

2003
Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 305, Issue:1

    Topics: Acetylcholine; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Cholinesterase Inhibitors; Dialysis; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Idazoxan; Piribedil; Prefrontal Cortex; Quinolines; Quinoxalines; Rats; Rats, Wistar

2003
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
    Brain research bulletin, 2003, May-15, Volume: 60, Issue:3

    Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Behavior, Animal; Brimonidine Tartrate; Choline O-Acetyltransferase; Female; Hippocampus; Idazoxan; In Vitro Techniques; Maze Learning; Memory Disorders; Methiothepin; Muscarinic Agonists; Norepinephrine; Oxotremorine; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Rats; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming; Tritium

2003
Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor.
    British journal of pharmacology, 2003, Volume: 140, Issue:2

    Topics: Adrenergic Agonists; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Catecholamines; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Ligands; Membrane Proteins; Models, Molecular; Molecular Structure; Mutation; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium

2003
alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.
    European journal of pharmacology, 2005, Jul-04, Volume: 517, Issue:1-2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Methiothepin; Naloxone; Narcotic Antagonists; Neurons; Norepinephrine; Oxazines; Piperazines; Piperidines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes

2005
K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil.
    Neuroscience research, 2006, Volume: 55, Issue:2

    Topics: Adrenergic alpha-Agonists; Adult; Aged; Amines; Anticonvulsants; Brimonidine Tartrate; Calcium Channel Blockers; Child; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Humans; Idazoxan; In Vitro Techniques; Male; Middle Aged; Norepinephrine; omega-Conotoxins; Pinacidil; Potassium; Quinoxalines; Time Factors; Tritium

2006
Presynaptic alpha-adrenoceptors in median preoptic nucleus modulate inhibitory neurotransmission from subfornical organ and organum vasculosum lamina terminalis.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2007, Volume: 292, Issue:5

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cells, Cultured; Hypothalamus; Idazoxan; Imidazoles; Isoproterenol; Norepinephrine; Prazosin; Preoptic Area; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Signal Transduction; Subfornical Organ

2007
Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis.
    Clinical and experimental immunology, 2009, Volume: 156, Issue:2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Colitis; Colon; Cytokines; Dextran Sulfate; Dopamine beta-Hydroxylase; Idazoxan; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Models, Animal; Quinoxalines; Tyrosine 3-Monooxygenase

2009
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
    Psychopharmacology, 2012, Volume: 221, Issue:1

    Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord

2012
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.
    European journal of pharmacology, 2012, Aug-05, Volume: 688, Issue:1-3

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Idazoxan; Male; Methoxamine; Movement; Neurons; Norepinephrine; Nucleus Accumbens; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2

2012
Prevention of neutrophil extravasation by α2-adrenoceptor-mediated endothelial stabilization.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Sep-15, Volume: 193, Issue:6

    Topics: Adherens Junctions; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Antigens, CD; beta Catenin; Brimonidine Tartrate; Cadherins; CD11b Antigen; Endothelium, Vascular; gamma Catenin; Humans; Idazoxan; Inflammation; Intercellular Adhesion Molecule-1; L-Selectin; Male; Mice; Neutrophils; Peritonitis; Quinoxalines; Receptors, Adrenergic, alpha-2; Thioglycolates; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha; Up-Regulation; Xylazine; Zymosan

2014
Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors.
    Psychoneuroendocrinology, 2015, Volume: 51

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Avoidance Learning; Basolateral Nuclear Complex; Brimonidine Tartrate; Idazoxan; Male; Memory; Microdialysis; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2

2015