quinoxalines has been researched along with glycine in 165 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (6.06) | 18.7374 |
| 1990's | 91 (55.15) | 18.2507 |
| 2000's | 40 (24.24) | 29.6817 |
| 2010's | 20 (12.12) | 24.3611 |
| 2020's | 4 (2.42) | 2.80 |
| Authors | Studies |
|---|---|
| Artaud, F; Chéramy, A; Desce, JM; Galli, T; Glowinski, J; Kemel, ML | 1 |
| Duman, RS; Hayward, MD; Nestler, EJ; Tallman, JF; Vaccarino, FM | 1 |
| Helm, SW; Henzi, V; MacDermott, AB; Reichling, DB | 1 |
| Kelly, JB; Wu, SH | 1 |
| Matsumoto, M; Scheller, MS; Strnat, MA; Zornow, MH | 1 |
| Besser, GM; Costa, A; Forsling, ML; Grossman, A; Hucks, D; Yasin, SA | 1 |
| Hayashi, M; Hirose, E; Ito, I; Kohda, A; Mitsunaga, S; Sugiyama, H; Tanabe, S | 1 |
| Inokuchi, H; Nishi, S; Polosa, C; Trzebski, A; Yoshimura, M | 1 |
| Bobichon, C; Cordi, A; Curutchet, P; de Carvalho, LP; Guet, T; Lambolez, B; Lepagnol, JM; Moreau, C; Randle, JC | 1 |
| Lodge, D; Millar, JD; Pralong, E | 1 |
| Fink, K; Göthert, M; Schultheiss, R | 1 |
| Calligaro, DO; Lodge, D; McQuaid, LA; Mitch, CH; O'Malley, PJ; Ornstein, PL; Schoepp, DD; Smith, EC; South, KK; True, RA | 1 |
| Hatta, K; Hori, T; Moroji, T; Okuwa, M; Yamamoto, T | 1 |
| Cherubini, E; Ito, S; Provini, L | 1 |
| Choi, DW; Koh, JY | 1 |
| Higashi, H; Inokuchi, H; Nishi, S; Nose, I | 1 |
| Ogita, K; Yoneda, Y | 3 |
| Clements, JD; Westbrook, GL | 1 |
| Abrahams, TP; Gillis, RA; Hornby, PJ; Taveira DaSilva, AM; Walton, DP | 1 |
| Jeng, YJ; Johnson, KM | 1 |
| Morita, Y; Nishimura, S; Sorimachi, M | 1 |
| Abele, AE; Miller, RJ; Scholz, KP; Scholz, WK | 1 |
| Jacocks, HM; McMahon, PN; Werling, LL | 1 |
| Momiyama, A; Takahashi, T | 1 |
| Paschetto, KA; Pullan, LM; Verticelli, AM | 1 |
| Okamoto, K; Sakai, Y; Sekiguchi, M | 1 |
| D'Angelo, E; Garthwaite, J; Rossi, P | 1 |
| Cler, JA; Emmett, MR; Iyengar, S; Mick, SJ; Rao, TS; Wood, PL | 1 |
| Thomson, AM | 1 |
| Dingledine, R; Kleckner, NW; McBain, CJ | 1 |
| Jägerstad, M; Skog, K | 1 |
| Alesiani, M; Cherici, G; Galli, A; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Dingledine, R; Kleckner, NW | 1 |
| Drejer, J; Honoré, T; Jensen, LH; Sheardown, MJ; Stidsen, CE | 1 |
| Jahr, CE; Lester, RA; Parker, JD; Quarum, ML; Weber, E | 1 |
| Harris, KM; Miller, RJ | 1 |
| Baudry, M; Kessler, M; Lynch, G | 1 |
| Birch, PJ; Grossman, CJ; Hayes, AG | 1 |
| Gerchakov, S; Schultz, HP | 1 |
| Grivas, S; Jägerstad, M; Negishi, C; Olsson, K; Sato, S; Sugimura, T; Tsuda, M; Wakabayashi, K | 1 |
| Bullock, R; Tsuchida, E | 1 |
| Bernardi, G; Bonci, A; Calabresi, P; Mercuri, NB; Stratta, F | 1 |
| Greenamyre, JT; Greene, JG | 1 |
| Aguglia, U; Bertorelli, R; De Sarro, A; De Sarro, G; Ongini, E | 1 |
| Miller, RF; Yu, W | 1 |
| Bigge, CF; Borosky, SA; Boxer, PA; Lescosky, LJ; Malone, TC; Nelson, CB; Ortwine, DF; Retz, DM; Schelkun, RM; Vartanian, MG | 1 |
| Block, F; Schwarz, M; Sontag, KH | 1 |
| Boos, R; Schneider, H; Wässle, H | 1 |
| Becquet, D; Deprez, P; Fache, MP; Faudon, M; Francois-Bellan, AM; Giraud, P; Hery, F; Hery, M | 1 |
| Guastella, J; Huettner, JE; Keana, JF; Weber, E; Woodward, RM | 1 |
| Martin, H; Todd, MM; Warner, DS | 1 |
| Dexter, F; McFarlane, C; Nader, A; Warner, DS | 1 |
| Barth, A; Malouf, AT; Newell, DW | 1 |
| Chetkovich, DM; Sweatt, JD | 1 |
| Gähwiler, BH; Gerber, U; Lüthi, A | 1 |
| D'Angelo, E; Rossi, P; Taglietti, V | 1 |
| Bähring, R; Grantyn, R; Martelli, EA; Standhardt, H | 1 |
| Ae, N; Antoku, F; Kato, T; Kodo, T; Nagata, R; Nishimura, T; Tanaka, Y; Tanno, N; Tatsuno, T; Yamaguchi, H | 1 |
| Jahr, CE; Lester, RA; Tong, G | 1 |
| Janáky, R; Oja, SS; Saransaari, P | 1 |
| Abe, K; Saito, H | 1 |
| Baudry, M; Shahi, K | 1 |
| Cappendijk, SL; de Vries, R; Dzoljic, MR | 1 |
| Jägerstad, M; Johansson, M; Skog, K | 1 |
| Cardoso, LF; Martini, LH; Souza, DO; Tasca, CI; Vendite, D | 1 |
| He, RQ; Li, CY; Wang, GL; Xu, J | 1 |
| Golding, NL; Oertel, D | 1 |
| Capparelli, MV; Codding, PW; Kindopp, TW; Kubicki, M | 1 |
| Akerman, KE; Holopainen, I; Janáky, R; Oja, SS; Varga, V | 1 |
| Cai, SX; Ilyin, VI; Keana, JF; Kher, SM; Shen, KZ; Tran, M; Weber, E; Whittemore, ER; Woodward, RM | 1 |
| Erdõ, SL; Molnár, P | 1 |
| Glitsch, M; Llano, I; Marty, A | 1 |
| Harashima, T; Hiramoto, K; Kato, T; Kikugawa, K; Moriya, N | 1 |
| Sheardown, MJ; Thomsen, C | 1 |
| Han Hsu, H; Hawkinson, JE; Huber, KR; Sahota, PS; Weber, E; Whitehouse, MJ | 1 |
| Bart, RD; Brinkhous, A; Pearlstein, R; Takaoka, S; Warner, DS | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Ilyin, V; Keana, JF; Kher, SM; Tran, M; Weber, E; Woodward, RM; Zhou, ZL | 1 |
| Cebers, G; Hou, YN; Liljequist, S; Terenius, L | 1 |
| Barth, A; Malouf, AT; Newell, DW; Ricciardi, TN | 1 |
| Komori, Y; Nabeshima, T; Nikai, T; Senzaki, K; Sugihara, H; Yamada, K | 1 |
| Anwyl, R; Rowan, MJ; Wang, Y; Wu, J | 1 |
| Beirne, JP; Massey, GW; Pearlstein, RD; Warner, DS | 1 |
| Isaacson, JS; Strowbridge, BW | 1 |
| Farre, C; Jacobson, I; Jardemark, K; Orwar, O; Zare, RN | 1 |
| Anchisi, D; Miniaci, MC; Strata, P; Tempia, F | 1 |
| Bahia, DS; Fanelli, F; Lee, M; Milligan, G; Rees, S; Wise, A | 1 |
| Arnold, E; Clark, AD; Das, K; Ding, J; Hsiou, Y; Hughes, SH; Kleim, JP; Riess, G; Rösner, M; Winkler, I | 1 |
| DeLorenzo, RJ; Pal, S; Sombati, S | 1 |
| Bergeron, R; Coyle, JT; Greene, RW; Meyer, TM | 1 |
| Acklin, P; Allgeier, H; Auberson, YP; Bischoff, S; Ofner, S; Sauer, D; Schmutz, M | 1 |
| Acklin, P; Allgeier, H; Auberson, YP; Biollaz, M; Bischoff, S; Ofner, S; Veenstra, SJ | 1 |
| Bonagamba, LG; Haibara, AS; Machado, BH | 1 |
| Bahia, DS; Jackson, VN; Milligan, G | 1 |
| Drejer, J; Gouliaev, AH; Jensen, LH; Mathiesen, C; Moller, A; Nielsen, EO; Varming, T; Wätjen, F | 1 |
| Blackburn, AC; Boxer, PA; Cordon, JJ; Heimbach, TH; Nelson, CB; Nikam, SS; Ortwine, DF; Rafferty, MF; Schwarz, RD; Vartanian, MG | 1 |
| Hanania, T; Johnson, KM | 1 |
| Blanc, EM; Guiramand, J; Jallageas, M; Recasens, M | 1 |
| Cozzi, A; Leonardi, P; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Pellicciari, R; Peruginelli, F | 1 |
| Doan, P; Lutfy, K; Nguyen, M; Weber, E | 1 |
| Miller, ED; Myhr, KL; Wong, RO; Wong, WT | 1 |
| Ametamey, SM; Auberson, YP; Bischoff, S; Bläuenstein, P; Carrey-Rémy, N; Kokic, M; Schmutz, M; Schubiger, PA; Willmann, M | 1 |
| Nakamura, K; Shirane, M | 1 |
| Brady, RO; Ferris, CD; Linden, DJ; Mothet, JP; Parent, AT; Rogawski, MA; Snyder, SH; Wolosker, H | 1 |
| Gottmann, K; Hatt, H; Mohrmann, R | 1 |
| Alojado, ME; Anchisi, D; Knöpfel, T; Strata, P; Tempia, F | 1 |
| Kawabe, A; Maruoka, Y; Nakamura, M; Ohtani, K; Tanaka, H; Yasuda, H | 1 |
| Barrachina, MD; Esplugues, JV; García-Zaragozá, E; Moreno, L | 1 |
| Mao, L; Wang, JQ | 1 |
| Nishiyama, T | 1 |
| Ardenghi, PG; Barros, DM; Izquierdo, I; Izquierdo, LA; Medina, JH; Mello e Souza, T; Pereira, P | 1 |
| Denk, W; Häusser, M; Wang, SS | 1 |
| Bull, DJ; Carr, CL; Fray, MJ; Gautier, EC; Mowbray, CE; Stobie, A | 1 |
| Jiang, L; Kang, J; Nedergaard, M; Xu, J | 1 |
| Asai, K; Fujita, K; Katano, H; Kato, T; Kawamura, Y; Masago, A; Yamada, K | 1 |
| Bonsi, P; Miniaci, MC; Pisani, A; Strata, P; Tempia, F | 1 |
| Brasnjo, G; Otis, TS | 1 |
| Cai, SX; Espitia, SA; Hawkinson, JE; Keana, JF; Kher, SM; Tran, M; Weber, E; Whittemore, ER; Woodward, RM; Zhou, ZL | 1 |
| Baskin, II; Palyulin, VA; Tikhonova, IG; Zefirov, NS | 1 |
| Cole, S; Gedge, J; Roffey, S; Walker, D; Webster, R; Wild, W | 1 |
| Callewaert, G; Leyssen, M; Robberecht, W; Van Damme, P; Van Den Bosch, L | 1 |
| Gear, RW; Levine, JD; Tambeli, CH; Young, A | 1 |
| Kim, Y; Oertel, D; Trussell, LO; Tzounopoulos, T | 1 |
| Albrecht, J; Hilgier, W; Oja, SS; Saransaari, P | 1 |
| Adolph, AR; Dowling, JE; Wong, KY | 1 |
| Duvoisin, RM; Grandes, P; Kushmerick, C; Price, GD; Puente, N; Renden, R; Taschenberger, H; von Gersdorff, H; Wadiche, JI | 1 |
| Belichenko, PV; Epstein, CJ; Kleschevnikov, AM; Malenka, RC; Mobley, WC; Villar, AJ | 1 |
| Wong, YH; Wu, EH | 1 |
| Bonhoeffer, T; Finski, A; Lohmann, C | 1 |
| Connolly, CN; Greenwood, S; Kushnareva, Y; Ward, MW | 1 |
| Hashikawa, T; Hayashi, Y; Kobayashi, S; Miyawaki, A; Nagai, T; Nakagawa, T; Neve, RL; Okamoto, K; Takao, K | 1 |
| Foley, CM; Hasser, EM; Hay, M; Mueller, PJ; Vogl, HW | 1 |
| Knöpfel, T; Mutoh, H; Yuan, Q | 1 |
| Gall, CM; Lin, CY; Lynch, G | 1 |
| Lee-Rivera, I; López, E; López-Colomé, AM; Palma, JP | 1 |
| Fan, XL; Li, Q; Song, XA; Yang, JC | 1 |
| Carey, MR; Regehr, WG | 1 |
| Bauer, I; Freynhagen, R; Hermanns, H; Kollosche, K; Lipfert, P; Muth-Selbach, U; Stegmann, JU | 1 |
| Chen, G; Ebner, T; Gao, W; Wang, X | 1 |
| Breustedt, J; Brose, N; Gundlfinger, A; Reim, K; Schmitz, D; Varoqueaux, F | 1 |
| Kim, Y; Trussell, LO | 1 |
| Leng, W; Qiu, W; Wang, W; Wei, R; Zhang, C | 1 |
| Colombari, E; Menani, JV; Moreira, TS; Takakura, AC | 1 |
| Chen, G; Ebner, TJ; Gao, W; Wang, X | 1 |
| Menzler, J; Zeck, G | 1 |
| Moreira, TS; Takakura, AC | 1 |
| Huang, C; Lei, H; Nie, X; Tang, H; Wang, Y; Zhao, XJ | 1 |
| Chen, Z; Ji, F; Liu, SY; Lu, W; Ren, SQ; Yao, W; Zhang, N; Zhang, XY | 1 |
| Fischer, L; Menescal-de-Oliveira, L; Monaliza, SL; Parada, CA; Tambeli, CH | 1 |
| Colbert, CM; Eskin, A; Pita-Almenar, JD; Zou, S | 1 |
| Anderson, MO; Synder, D; Thiagarajah, JR; Tradtrantip, L; Verkman, AS | 1 |
| Goswami, D; Jurado, S; Malenka, RC; Molina, AJ; Südhof, TC; Zhang, Y | 1 |
| Dong, Y; Grace, AA; Huang, YH; Ishikawa, M; Neumann, PA; Otaka, M; Schlüter, OM; Winters, BD | 1 |
| Brown, AM; Chen, S; Evans, RD; Hamner, MA; Ransom, BR; Yang, X; Ye, ZC | 1 |
| Chen, Q; Deng, Y; Mu, P; Tang, X; Wang, L; Wang, Y; Wu, K; Xu, M; Zheng, M; Zheng, Y | 1 |
| Gibson, JR; Huber, KM; Loerwald, KW; Patel, AB | 1 |
| Babic, S; Hachimine, P; Ranaldi, R; Seepersad, N | 1 |
| Bari, SB; Ugale, VG | 1 |
| Bernazar, L; Cañete, Á; Carathanassis, N; De la Fuente, JR; Díaz-Hernández, D; Saitz, C | 1 |
| Collingridge, GL; Jia, Z; Leung, C; Liu, A; Meng, Y; Park, P; Qi, J; Xia, S; Xie, W; Zhou, Z | 1 |
| Deshayes, E; Fersing, C; Guiu, B; Meunier, L; Quenet, F | 1 |
| Chen, L; Cheng, S; Li, B; Lin, Z; Wang, M; Wang, W; Yao, M; Yin, Q; Zhang, Y | 1 |
| Chen, J; Cui, H; Huang, H; Li, X; Wei, S; Zhang, C | 1 |
| Fan, D; Jiang, Q; Jiang, Y; Wang, M; Zhao, Y | 1 |
2 review(s) available for quinoxalines and glycine
| Article | Year |
|---|---|
The glycine coagonist site of the NMDA receptor.
Topics: Animals; Binding Sites; Brain; Glycine; Kainic Acid; Kynurenic Acid; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 1990 |
CFTR inhibitors.
Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Discovery; Glycine; High-Throughput Screening Assays; Humans; Models, Molecular; Molecular Structure; Mutation; Polycystic Kidney Diseases; Quinoxalines; Small Molecule Libraries; Thiazolidinediones | 2013 |
163 other study(ies) available for quinoxalines and glycine
| Article | Year |
|---|---|
Modulation of GABA release by alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate and N-methyl-D-aspartate receptors in matrix-enriched areas of the rat striatum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Dizocilpine Maleate; gamma-Aminobutyric Acid; Glycine; Histocytochemistry; Ibotenic Acid; Male; Nerve Endings; Perfusion; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptosomes; Tetrodotoxin; Veratridine | 1992 |
Differential induction of immediate early genes by excitatory amino acid receptor types in primary cultures of cortical and striatal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Blotting, Northern; Cells, Cultured; Cerebral Cortex; Corpus Striatum; DNA-Binding Proteins; Early Growth Response Protein 1; Gene Expression Regulation; Genes, fos; Genes, jun; Genes, Regulator; Glutamates; Glutamic Acid; Glycine; Immediate-Early Proteins; Isoquinolines; Neurons; Piperazines; Protein Kinase Inhibitors; Proto-Oncogenes; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Sulfonamides; Transcription Factors | 1992 |
L-proline activates glutamate and glycine receptors in cultured rat dorsal horn neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Female; Glutamates; Glycine; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Pregnancy; Proline; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1992 |
NMDA, non-NMDA and glycine receptors mediate binaural interaction in the lateral superior olive: physiological evidence from mouse brain slice.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Electric Stimulation; Functional Laterality; Glycine; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Olivary Nucleus; Quinoxalines; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1992 |
AMPA and NMDA receptor antagonists do not decrease hippocampal glutamate concentrations during transient global ischemia.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Hippocampus; Ischemic Attack, Transient; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reperfusion | 1992 |
Differential effects of neuroexcitatory amino acids on corticotropin-releasing hormone-41 and vasopressin release from rat hypothalamic explants.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine Vasopressin; Corticotropin-Releasing Hormone; Glycine; Hypothalamus; Kainic Acid; Magnesium; Male; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar | 1992 |
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Cycloleucine; Egtazic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Oocytes; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Resorcinols; RNA, Messenger; Xenopus | 1992 |
Fast inhibitory postsynaptic potentials and responses to inhibitory amino acids of sympathetic preganglionic neurons in the adult cat.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Atropine; Bicuculline; Cats; gamma-Aminobutyric Acid; Ganglia, Sympathetic; Glycine; Membrane Potentials; Naloxone; Neurons; Phentolamine; Quinoxalines; Spinal Cord; Strychnine; Synapses | 1992 |
Quinoxaline derivatives: structure-activity relationships and physiological implications of inhibition of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptor-mediated currents and synaptic potentials.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebral Cortex; Electrophysiology; Evoked Potentials; Female; Glycine; Hippocampus; Ibotenic Acid; Kainic Acid; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Structure-Activity Relationship; Synapses; Xenopus | 1992 |
Specificity and potency of N-methyl-D-aspartate glycine site antagonists and of mephenesin on the rat spinal cord in vitro.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Glycine; Ibotenic Acid; Indoles; Kynurenic Acid; Mephenesin; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1992 |
Stimulation of noradrenaline release in human cerebral cortex mediated by N-methyl-D-aspartate (NMDA) and non-NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Glycine; Humans; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin; Tritium | 1992 |
Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glycine; Ibotenic Acid; Male; Quinazolines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1992 |
Effects of glycine antagonists on Mg(2+)- and glycine-induced [3H]N-(1-[2-thienyl]cyclohexyl)-3,4-piperidine binding.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glycine; Kinetics; Magnesium; Male; Phencyclidine; Quinoxalines; Rats; Rats, Wistar; Receptors, Phencyclidine; Synaptic Membranes; Tritium | 1992 |
L-homocysteic acid mediates synaptic excitation at NMDA receptors in the hippocampus.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Evoked Potentials; Glutamates; Glycine; Hippocampus; Homocysteine; In Vitro Techniques; Male; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Synapses; Tetrodotoxin | 1991 |
Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cell Line; Cell Survival; Cerebral Cortex; Fetus; Glutamates; Glutamic Acid; Glycine; Kainic Acid; Mice; N-Methylaspartate; Neurons; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1991 |
Synaptic responses of guinea pig and rat central amygdala neurons in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Adenosine; Amino Acids; Amygdala; Animals; Baclofen; Electric Stimulation; Electrodes; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Male; Neuromuscular Depolarizing Agents; Neurons; Quinoxalines; Rats; Rats, Inbred Strains; Synapses | 1991 |
Heterogeneity of the N-methyl-D-aspartate receptor ionophore complex in rat brain, as revealed by ligand binding techniques.
Topics: Animals; Binding, Competitive; Brain; Dizocilpine Maleate; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Ligands; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding Sites; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Neurons; Osmolar Concentration; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1991 |
An excitatory amino acid(s) in the ventrolateral medulla is (are) required for breathing to occur in the anesthetized cat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Cats; Female; Glycine; Kynurenic Acid; Male; Medulla Oblongata; Microinjections; Piperazines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Respiration | 1991 |
Pharmacological evidence for N-methyl-D-aspartate receptors on nigrostriatal dopaminergic nerve terminals.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Corpus Striatum; Dopamine; Female; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Nerve Endings; Phencyclidine; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synaptosomes; Tetrodotoxin | 1991 |
N-methyl-D-aspartate and aspartate raise the cytosolic free calcium concentration by acting upon receptors transiently expressed on immature cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Animals; Animals, Newborn; Aspartic Acid; Calcium; Cerebellum; Cytosol; Gallopamil; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Magnesium; N-Methylaspartate; Organophosphorus Compounds; Piperazines; Purkinje Cells; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Excitotoxicity induced by enhanced excitatory neurotransmission in cultured hippocampal pyramidal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzofurans; Calcium; Cell Survival; Cells, Cultured; Electrophysiology; Fluorescent Dyes; Fura-2; Glycine; Hippocampus; Magnesium; Neurons; Nimodipine; Pyramidal Tracts; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
Regulation of [3H]dopamine release from guinea pig striatum by NMDA receptor/channel activators and inhibitors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Dopamine; Glycine; Guinea Pigs; Ion Channels; Magnesium; Male; N-Methylaspartate; Piperazines; Pyrrolidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid | 1990 |
Single-channel currents underlying glycinergic inhibitory postsynaptic responses in spinal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Electric Conductivity; Glycine; In Vitro Techniques; Ion Channel Gating; Ion Channels; Membrane Potentials; Neurons; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Synapses | 1991 |
Agonist-like character of the (R)-enantiomer of 1-hydroxy-3-amino-pyrrolid-2-one (HA-966).
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Glycine; Kynurenic Acid; Male; Pyrrolidinones; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Spermine; Stereoisomerism; Synaptosomes | 1991 |
6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [3H]glycine binding sites on the N-methyl-D-aspartate receptor complex.
Topics: Animals; Binding Sites; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Resistance; Glutamates; Glutamic Acid; Glycine; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine; Synaptic Membranes; Tritium | 1990 |
Glycine-insensitive NMDA-sensitive receptor expressed in Xenopus oocytes by guinea pig cerebellar mRNA.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cerebellum; Electric Conductivity; Female; Glycine; Guinea Pigs; Kynurenic Acid; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Oocytes; Phencyclidine; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; RNA, Messenger; Xenopus laevis | 1990 |
Dual-component NMDA receptor currents at a single central synapse.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Cerebellum; Electric Conductivity; Glycine; Kinetics; Magnesium; Neurons; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
6,7-Dinitroquinoxaline-2,3-dione and 6-nitro,7-cyanoquinoxaline-2,3-dione antagonize responses mediated by N-methyl-D-aspartate and NMDA-associated glycine recognition sites in vivo: measurements of cerebellar cyclic-GMP.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebellum; Cyclic AMP; Glycine; Harmaline; Kinetics; Male; Mice; N-Methylaspartate; Pyrrolidinones; Quinoxalines; Quisqualic Acid; Serine | 1990 |
Augmentation by glycine and blockade by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) of responses to excitatory amino acids in slices of rat neocortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cerebral Cortex; Drug Interactions; Electrophysiology; Female; Glycine; Homocysteine; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Membrane Potentials; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Rats; Somatosensory Cortex | 1990 |
Effects of monosaccharides and disaccharides on the formation of food mutagens in model systems.
Topics: Chromatography, High Pressure Liquid; Creatine; Creatinine; Disaccharides; Ethylene Glycols; Food; Glycine; Hot Temperature; Maillard Reaction; Monosaccharides; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella; Temperature | 1990 |
Quinoxalines interact with the glycine recognition site of NMDA receptors: studies in guinea-pig myenteric plexus and in rat cortical membranes.
Topics: Animals; Cerebral Cortex; Glycine; Guinea Pigs; In Vitro Techniques; Ion Channels; Kinetics; Kynurenic Acid; Male; Myenteric Plexus; Quinoxalines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Biological Assay; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Xenopus laevis | 1989 |
Abolition of the NMDA-mediated responses by a specific glycine antagonist, 6,7-dichloroquinoxaline-2,3-dione (DCQX).
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Glycine; Kinetics; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes | 1989 |
A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.
Topics: Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; Cortical Spreading Depression; Female; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pregnancy; Pyrrolidinones; Quinoxalines; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Seizures; Strychnine | 1989 |
Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor-associated glycine binding site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Glycine; N-Methylaspartate; Quinoxalines; Rats; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
CNQX (6-cyano-7-nitroquinoxaline-2,3-dione) antagonizes NMDA-evoked [3H]GABA release from cultured cortical neurons via an inhibitory action at the strychnine-insensitive glycine site.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Glycine; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Strychnine | 1989 |
Quinoxaline derivatives are high-affinity antagonists of the NMDA receptor-associated glycine sites.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Glycine; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Glycine; In Vitro Techniques; N-Methylaspartate; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1988 |
Quinoxaline studies. XIV. Potential anticancer agents. Some quinoxaline amino acid and dipeptide derivatives related to quinoxaline antibiotics.
Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Dipeptides; Glycine; Leukemia L1210; Methionine; Mice; Quinoxalines; Serine; Valine | 1969 |
Formation of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in a model system by heating creatinine, glycine and glucose.
Topics: Chemical Phenomena; Chemistry; Creatinine; Glucose; Glycine; Hot Temperature; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Chemical; Mutagens; Quinoxalines | 1984 |
The effect of the glycine site-specific N-methyl-D-aspartate antagonist ACEA1021 on ischemic brain damage caused by acute subdural hematoma in the rat.
Topics: Animals; Binding, Competitive; Blood Pressure; Brain Ischemia; Excitatory Amino Acid Antagonists; Glycine; Hematoma, Subdural; Humans; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1995 |
Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dopamine; Electrophysiology; Female; Glycine; Male; Neurons; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Tetrodotoxin | 1993 |
Characterization of the excitotoxic potential of the reversible succinate dehydrogenase inhibitor malonate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Body Temperature; Brain Diseases; Cell Death; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Isoquinolines; Male; Malonates; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Succinate Dehydrogenase | 1995 |
Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felbamate in DBA/2 mice.
Topics: Acoustic Stimulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding, Competitive; Disease Models, Animal; Dose-Response Relationship, Drug; Felbamate; Female; Glycine; Injections, Intraperitoneal; Injections, Intraventricular; Kynurenic Acid; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Phenylcarbamates; Propylene Glycols; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Serine; Stereoisomerism; Synaptic Transmission | 1994 |
NBQX suppresses inhibitory glycine currents in retinal ganglion cells.
Topics: Ambystoma; Animals; Glycine; In Vitro Techniques; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Quinoxalines; Receptors, AMPA; Receptors, Glycine; Retinal Ganglion Cells; Tetrodotoxin | 1994 |
Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant act
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cells, Cultured; Cerebral Cortex; Computer Graphics; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Mice; Models, Molecular; Molecular Structure; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Structure-Activity Relationship | 1995 |
Non-NMDA-mediated transmission of somatosensory-evoked potentials in the rat thalamus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Anticonvulsants; Electric Stimulation; Evoked Potentials, Somatosensory; Glycine; Ibotenic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Somatosensory Cortex; Stereotaxic Techniques; Synaptic Transmission; Thalamic Nuclei | 1993 |
Voltage- and transmitter-gated currents of all-amacrine cells in a slice preparation of the rat retina.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cobalt; Electrophysiology; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Potassium Channels; Quinoxalines; Rats; Receptors, Amino Acid; Retina; Retinal Ganglion Cells; Sodium Channels; Strychnine; Synapses; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin | 1993 |
Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Kinetics; Neurons; Quinoxalines; Quisqualic Acid; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Taurine; Tryptophan | 1993 |
In vitro pharmacology of ACEA-1021 and ACEA-1031: systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites.
Topics: Animals; Binding Sites; Brain; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Electrophysiology; Female; Glycine; Kynurenic Acid; Neurons; Oocytes; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Complementary; RNA, Messenger; Transcription, Genetic; Xenopus laevis | 1995 |
Effects of glycine receptor antagonism on spreading depression in the rat.
Topics: Animals; Binding Sites; Cortical Spreading Depression; Dose-Response Relationship, Drug; Electric Stimulation; Electroencephalography; Glycine; Ketamine; Macromolecular Substances; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1994 |
Glycine receptor antagonism. Effects of ACEA-1021 on the minimum alveolar concentration for halothane in the rat.
Topics: Animals; Binding, Competitive; Blood Pressure; Body Weight; Carbon Dioxide; Drug Interactions; Glycine; Halothane; Hydrogen-Ion Concentration; Male; Oxygen; Partial Pressure; Pulmonary Alveoli; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Strychnine | 1995 |
Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures.
Topics: Animals; Brain Ischemia; Cell Death; Dizocilpine Maleate; Glycine; Glycine Agents; Hippocampus; Kynurenic Acid; Neurons; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1995 |
nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase.
Topics: 2-Amino-5-phosphonovalerate; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 6-Cyano-7-nitroquinoxaline-2,3-dione; Adenylyl Cyclases; Animals; Ascorbic Acid; Calcium; Calmodulin; Cell Membrane; Colforsin; Cyclic AMP; Deoxyadenosines; Dopamine; Enzyme Activation; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Isoproterenol; Kinetics; Models, Neurological; N-Methylaspartate; Pyramidal Tracts; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sulfonamides; Theophylline; Trifluoperazine | 1993 |
Inhibition of a slow synaptic response by a metabotropic glutamate receptor antagonist in hippocampal CA3 pyramidal cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Bicuculline; Cycloleucine; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Nerve Fibers; Neurotoxins; Pyramidal Cells; Quinoxalines; Rats; Receptors, Glutamate; Synapses | 1993 |
Voltage-dependent kinetics of N-methyl-D-aspartate synaptic currents in rat cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebellum; Electric Stimulation; Evoked Potentials; Glycine; In Vitro Techniques; Kinetics; Nerve Fibers; Neurons; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 1994 |
GABA-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons?
Topics: Acetylcarnitine; Acetylcholine; Action Potentials; Animals; Bicuculline; Chloride Channels; Clonazepam; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Pentobarbital; Picrotoxin; Potassium Chloride; Pregnanolone; Quinoxalines; Retina; Retinal Ganglion Cells; Strychnine; Substrate Specificity; Tetrodotoxin; Zinc | 1994 |
Tricyclic quinoxalinediones: 5,6-dihydro-1H-pyrrolo[1,2,3-de] quinoxaline-2,3-diones and 6,7-dihydro-1H,5H-pyrido[1,2,3-de] quinoxaline-2,3-diones as potent antagonists for the glycine binding site of the NMDA receptor.
Topics: Animals; Binding Sites; Glycine; Mice; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1994 |
Interactions between the glycine and glutamate binding sites of the NMDA receptor.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kinetics; Neurons; Pyrrolidinones; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synapses; Time Factors | 1993 |
Release of GABA from rat hippocampal slices: involvement of quisqualate/N-methyl-D-aspartate-gated ionophores and extracellular magnesium.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Dizocilpine Maleate; Extracellular Space; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Ion Channel Gating; Magnesium; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Pharmacological isolation and characterization of NMDA receptor-mediated synaptic potential in the dentate gyrus of rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Glycine; Hippocampus; In Vitro Techniques; Kynurenic Acid; Magnesium; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Glycine-induced changes in synaptic efficacy in hippocampal slices involve changes in AMPA receptors.
Topics: Animals; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1993 |
Excitatory amino acid receptor antagonists and naloxone-precipitated withdrawal syndrome in morphine-dependent mice.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Glycine; Kynurenic Acid; Male; Mice; Morphine Dependence; Naloxone; Quinoxalines; Receptors, Amino Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Substance Withdrawal Syndrome | 1993 |
Effects of edible oils and fatty acids on the formation of mutagenic heterocyclic amines in a model system.
Topics: Amines; Creatinine; Dietary Fats, Unsaturated; Fatty Acids; Glucose; Glycine; Heterocyclic Compounds; Mutagens; Oxidation-Reduction; Quinoxalines | 1993 |
Modulation of adenosine-induced cAMP accumulation via metabotropic glutamate receptors in chick optic tectum.
Topics: Adenosine; Alanine; Animals; Benzoates; Chickens; Cyclic AMP; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Quinoxalines; Receptors, Metabotropic Glutamate; Superior Colliculi | 1995 |
Some fluorescent properties of non-enzymic transamination and measurement of the relative molecular mass of protein.
Topics: Glycine; Molecular Weight; Peptides; Protein Conformation; Proteins; Quinoxalines; Spectrometry, Fluorescence; Structure-Activity Relationship; Transaminases | 1995 |
Context-dependent synaptic action of glycinergic and GABAergic inputs in the dorsal cochlear nucleus.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Afferent Pathways; Animals; Cochlear Nucleus; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Membrane Potentials; Mice; Mice, Inbred CBA; Muscimol; Neural Inhibition; Neurons; Quinoxalines; Synaptic Transmission; Time Factors | 1996 |
Hydrogen-bond patterns in 1,4-dihydro-2,3-quinoxalinediones: ligands for the glycine modulatory site on the NMDA receptor.
Topics: Anticonvulsants; Binding Sites; Crystallography, X-Ray; Glycine; Hydrogen Bonding; Ligands; Molecular Conformation; Molecular Structure; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1996 |
Endogenous gamma-L-glutamylglutamate is a partial agonist at the N-methyl-D-aspartate receptors in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium; Cells, Cultured; Cerebellum; Dipeptides; Drug Synergism; Glutamates; Glutamic Acid; Glycine; Magnesium; N-Methylaspartate; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1995 |
Pharmacology of ACEA-1416: a potent systemically active NMDA receptor glycine site antagonist.
Topics: Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Male; Mice; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Xenopus laevis | 1996 |
Differential effects of five glycine site antagonists on NMDA receptor desensitisation.
Topics: Animals; Benzothiadiazines; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Quinolones; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Benzoates; Colforsin; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Interneurons; Kinetics; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin | 1996 |
Formation of the mutagenic/carcinogenic imidazoquinoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants.
Topics: Anticarcinogenic Agents; Antioxidants; Carcinogens; Creatinine; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Glucose; Glycine; Imidazoles; Phenols; Quinoxalines | 1996 |
Phenylglycines can evoke quisqualate-primed depolarizations in rat cingulate cortex: an effect associated with [3H]DL-AP4 uptake.
Topics: Aminobutyrates; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Gyrus Cinguli; Osmolar Concentration; Piperazines; Quinoxalines; Quisqualic Acid; Rats; Tritium | 1996 |
The N-methyl-D-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in rat brain.
Topics: Animals; Brain; Cerebral Cortex; Excitatory Amino Acid Antagonists; Female; Glycine; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Neuroprotective effect of NMDA receptor glycine recognition site antagonism persists when brain temperature is controlled.
Topics: Animals; Binding Sites; Brain Damage, Chronic; Brain Ischemia; Cerebral Infarction; Excitatory Amino Acid Antagonists; Fever; Glycine; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Temperature | 1997 |
Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.
Topics: Animals; Anticonvulsants; Binding Sites; Binding, Competitive; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Oocytes; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Structure-Activity Relationship; Xenopus | 1997 |
Characterization of NMDA- and AMPA-induced enhancement of AP-1 DNA binding activity in rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Cerebellum; Dizocilpine Maleate; DNA-Binding Proteins; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kinetics; N-Methylaspartate; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Transcription Factor AP-1 | 1997 |
Glycine causes increased excitability and neurotoxicity by activation of NMDA receptors in the hippocampus.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Animals, Newborn; Benzoxazines; Cell Death; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Neurons; Neurotoxins; Organ Culture Techniques; Oxazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Changes in extracellular nitrite and nitrate levels after inhibition of glial metabolism with fluorocitrate.
Topics: Aconitate Hydratase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Benzoates; Cerebellum; Citrates; Citric Acid Cycle; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glycine; Male; N-Methylaspartate; Neuroglia; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Nitroarginine; Quinoxalines; Rats; Rats, Wistar; Substrate Specificity | 1997 |
Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Animals; Benzoates; Carbazoles; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Long-Term Potentiation; Neurons; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinases; Purinones; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1998 |
Neuroprotective effects of NMDA receptor glycine recognition site antagonism: dependence on glycine concentration.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Kainic Acid; L-Lactate Dehydrogenase; Neuroprotective Agents; Osmolar Concentration; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 1998 |
Olfactory reciprocal synapses: dendritic signaling in the CNS.
Topics: 2-Amino-5-phosphonovalerate; Animals; Axons; Calcium; Calcium Channel Blockers; Calcium Channels; Dendrites; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Models, Neurological; Nifedipine; Olfactory Bulb; omega-Conotoxin GVIA; omega-Conotoxins; Patch-Clamp Techniques; Peptides; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptic Transmission; Tetrodotoxin | 1998 |
Screening of receptor antagonists using agonist-activated patch clamp detection in chemical separations.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Electrophoresis, Capillary; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ion Channels; Mathematics; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, Cell Surface | 1998 |
Postsynaptic current mediated by metabotropic glutamate receptors in cerebellar Purkinje cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Bicuculline; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; GABA Antagonists; Glycine; Male; Nerve Fibers; Neural Inhibition; Patch-Clamp Techniques; Protein Kinase C; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission; Type C Phospholipases | 1998 |
Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Brimonidine Tartrate; Cell Line; Cysteine; Glycine; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Pertussis Toxin; Protein Binding; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Transfection; Virulence Factors, Bordetella | 1998 |
Structures of Tyr188Leu mutant and wild-type HIV-1 reverse transcriptase complexed with the non-nucleoside inhibitor HBY 097: inhibitor flexibility is a useful design feature for reducing drug resistance.
Topics: Antiviral Agents; Crystallography, X-Ray; Drug Design; Drug Resistance; Glutamic Acid; Glycine; HIV Reverse Transcriptase; Leucine; Models, Molecular; Molecular Conformation; Mutation; Quinoxalines; Reverse Transcriptase Inhibitors; Tyrosine | 1998 |
Prolonged activation of the N-methyl-D-aspartate receptor-Ca2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Benzoates; Calcium; Cells, Cultured; Dizocilpine Maleate; Egtazic Acid; Epilepsy; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Magnesium; Membrane Potentials; Microscopy, Confocal; Neurons; Nifedipine; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 1998 |
Modulation of N-methyl-D-aspartate receptor function by glycine transport.
Topics: 2-Amino-5-phosphonovalerate; Amino Acid Transport Systems, Neutral; Animals; Bicuculline; Carrier Proteins; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Plasma Membrane Transport Proteins; Hippocampus; In Vitro Techniques; Patch-Clamp Techniques; Pyramidal Cells; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 1998 |
5-Aminomethylquinoxaline-2,3-diones, Part III: Arylamide derivatives as highly potent and selective glycine-site NMDA receptor antagonists.
Topics: Animals; Excitatory Amino Acid Antagonists; Glycine; Mice; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1998 |
5-Aminomethylquinoxaline-2,3-diones. Part II: N-aryl derivatives as novel NMDA/glycine and AMPA antagonists.
Topics: Excitatory Amino Acid Antagonists; Glycine; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1998 |
Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats.
Topics: Animals; Benzoates; Cardiovascular Physiological Phenomena; Chemoreceptor Cells; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Microinjections; Quinoxalines; Rats; Rats, Wistar; Reflex; Solitary Nucleus; Sympathetic Nervous System; Synaptic Transmission | 1999 |
Modulation of relative intrinsic activity of agonists at the alpha-2A adrenoceptor by mutation of residue 351 of G protein gi1alpha.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; COS Cells; Cysteine; Dose-Response Relationship, Drug; Epinephrine; Glycine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Point Mutation; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Swine; Yohimbine | 1999 |
SPD 502: a water-soluble and in vivo long-lasting AMPA antagonist with neuroprotective activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Cells, Cultured; Cerebral Cortex; Electroshock; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Isoquinolines; Kainic Acid; Kinetics; Male; Membrane Potentials; Mice; Mice, Inbred Strains; Molecular Structure; Neurons; Neuroprotective Agents; Patch-Clamp Techniques; Pipecolic Acids; Pyrroles; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Stereoisomerism; Tetrahydroisoquinolines | 1999 |
Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives.
Topics: Animals; Anticonvulsants; Binding, Competitive; Cerebral Cortex; Drug Design; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Male; Mice; Models, Molecular; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glycine; Solubility; Synaptosomes | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Benzoates; Cell Division; Cell Survival; Cells, Cultured; Cellular Senescence; Cycloleucine; Cytarabine; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fibroblast Growth Factor 2; Glutamic Acid; Glycine; Hippocampus; Inositol Phosphates; Neuroglia; Neurons; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Type C Phospholipases | 1999 |
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia.
Topics: Animals; Animals, Newborn; Astrocytes; Benzoates; Bridged Bicyclo Compounds; Cell Death; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gerbillinae; Glycine; Indans; Ischemic Attack, Transient; Mice; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Pyramidal Cells; Quinoxalines; Receptors, Metabotropic Glutamate; Resorcinols | 1999 |
Effects of ACEA-1328, a NMDA receptor/glycine site antagonist, on U50,488H-induced antinociception and tolerance.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Glycine; Male; Mice; Nociceptors; Pain; Pain Measurement; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa | 1999 |
Developmental changes in the neurotransmitter regulation of correlated spontaneous retinal activity.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Bicuculline; Cholinergic Fibers; Excitatory Amino Acid Antagonists; Ferrets; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Glycine Agents; Interneurons; Periodicity; Quinoxalines; Retina; Retinal Ganglion Cells; Strychnine; Synaptic Transmission; Vision, Ocular; Visual Pathways | 2000 |
Synthesis, radiolabelling and biological characterization of (D)-7-iodo-N-(1-phosphonoethyl)-5-aminomethylquinoxaline-2,3-dione, a glycine-binding site antagonist of NMDA receptors.
Topics: Animals; Anticonvulsants; Binding Sites; Female; Glycine; Inhibitory Concentration 50; Iodine Radioisotopes; Kidney; Mice; Mice, Inbred BALB C; Organophosphonates; Quinoxalines; Radioligand Assay; Radiopharmaceuticals; Receptors, N-Methyl-D-Aspartate; Substrate Specificity; Tissue Distribution | 2000 |
Group II metabotropic glutamate receptors are a common target of N-anisoyl-GABA and 1S,3R-ACPD in enhancing ACh release in the prefrontal cortex of freely moving SHRSP.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Anisoles; Benzoates; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indans; Male; Microdialysis; Perfusion; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, AMPA; Receptors, Metabotropic Glutamate; Thalamic Nuclei; Wakefulness | 2000 |
D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.
Topics: Aging; Animals; Astrocytes; Cells, Cultured; Cerebellum; D-Amino-Acid Oxidase; Embryo, Mammalian; Glycine; Hippocampus; In Vitro Techniques; Ligands; Male; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Stereoisomerism | 2000 |
Developmental regulation of subunit composition of extrasynaptic NMDA receptors in neocortical neurones.
Topics: Animals; Cells, Cultured; Coculture Techniques; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Glycine; Ion Channels; Neocortex; Neurons; Patch-Clamp Techniques; Picrotoxin; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Synapses | 2000 |
Elevation of intradendritic sodium concentration mediated by synaptic activation of metabotropic glutamate receptors in cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dendrites; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Image Processing, Computer-Assisted; Membrane Potentials; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; Patch-Clamp Techniques; Picrotoxin; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Sodium; Synapses; Synaptic Transmission; Tetrodotoxin | 2000 |
Blocking the glycine-binding site of NMDA receptors prevents the progression of ischemic pathology induced by bilateral carotid artery occlusion in spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Body Temperature; Body Water; Brain Ischemia; Carotid Artery Thrombosis; Disease Models, Animal; Glycine; Male; Motor Activity; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, N-Methyl-D-Aspartate; Survival Rate | 2000 |
Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion.
Topics: Animals; Benzoates; Cyclic GMP; Dizocilpine Maleate; Dose-Response Relationship, Drug; Endotoxins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Glycine; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pentagastrin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Solubility; Stomach; Vagotomy | 2000 |
Motor stimulation following bilateral injection of the group-I metabotropic glutamate receptor agonist into the dorsal striatum of rats: evidence against dependence on ionotropic glutamate receptors.
Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Kainic Acid; Male; Microinjections; Motor Activity; N-Methylaspartate; Neostriatum; Neurons; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Stimulation, Chemical | 2000 |
Interaction among NMDA receptor-, NMDA glycine site- and AMPA receptor antagonists in spinally mediated analgesia.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Behavior, Animal; Binding Sites; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Glycine; Injections, Spinal; Motor Activity; Nociceptors; Pain Measurement; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2000 |
Molecular signalling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats.
Topics: 2-Amino-5-phosphonovalerate; Adenylyl Cyclases; Animals; Avoidance Learning; Benzoates; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Entorhinal Cortex; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Functional Laterality; Glycine; Hippocampus; Injections; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2000 |
Coincidence detection in single dendritic spines mediated by calcium release.
Topics: Animals; Axons; Benzoates; Calcium Signaling; Dendrites; Electric Stimulation; Excitatory Amino Acid Antagonists; Glycine; Membrane Potentials; Neural Inhibition; Neuronal Plasticity; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Thapsigargin | 2000 |
Structure-activity relationships of 1,4-dihydro-(1H,4H)-quinoxaline-2,3-diones as N-methyl-D-aspartate (glycine site) receptor antagonists. 1. Heterocyclic substituted 5-alkyl derivatives.
Topics: Aminoquinolines; Animals; Cell Membrane; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glycine; Indicators and Reagents; Mice; Models, Molecular; Motor Activity; N-Methylaspartate; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 2001 |
A kainate receptor increases the efficacy of GABAergic synapses.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoates; Benzodiazepines; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glycine; Hippocampus; In Vitro Techniques; Interneurons; Kainic Acid; Neurons; Protein Kinase C; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Staurosporine; Synapses; Tetradecanoylphorbol Acetate; Tetrodotoxin | 2001 |
A metabotropic glutamate receptor antagonist, alpha-methyl-4-carboxyphenylglycine, attenuates immediate early gene mRNA expression following traumatic injury in cultured rat cortical glial cells.
Topics: Animals; Benzoates; Brain Injuries; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation; Genes, Immediate-Early; Gliosis; Glycine; Nerve Regeneration; Neuroglia; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Transcriptional Activation | 2001 |
Presynaptic modulation by group III metabotropic glutamate receptors (mGluRs) of the excitatory postsynaptic potential mediated by mGluR1 in rat cerebellar Purkinje cells.
Topics: Animals; Benzoates; Bicuculline; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Male; Purkinje Cells; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Presynaptic | 2001 |
Neuronal glutamate transporters control activation of postsynaptic metabotropic glutamate receptors and influence cerebellar long-term depression.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Benzoates; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Glycine; Long-Term Potentiation; Nerve Fibers; Neural Inhibition; Organ Culture Techniques; Picrotoxin; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Tetrodotoxin | 2001 |
Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists.
Topics: Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Quinoxalines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 2003 |
CoMFA and homology-based models of the glycine binding site of N-methyl-d-aspartate receptor.
Topics: Binding Sites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Quinolones; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Sequence Homology, Amino Acid | 2003 |
Pharmacokinetics and disposition of a novel NMDA glycine site antagonist (UK-240,455) in rats, dogs and man.
Topics: Adolescent; Adult; Animals; Bile; Binding Sites; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Central Nervous System; Dogs; Glycine; Humans; Male; Middle Aged; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tissue Distribution | 2003 |
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Behavior, Animal; Calcium; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Forelimb; Glycine; Hand Strength; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Psychomotor Performance; Quinoxalines; Receptors, AMPA | 2003 |
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 2003 |
Cell-specific, spike timing-dependent plasticities in the dorsal cochlear nucleus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Cochlear Nucleus; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; Glycine Agents; In Vitro Techniques; Long-Term Potentiation; Mice; Mice, Inbred ICR; Neural Inhibition; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Quinoxalines; Strychnine; Synaptic Transmission; Time Factors | 2004 |
A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia.
Topics: Allosteric Regulation; Ammonia; Animals; Binding Sites; Corpus Striatum; Cyclic GMP; Glycine; Male; Microdialysis; Microinjections; Neurons; Neurotoxins; Nitric Oxide; Organophosphonates; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2004 |
Retinal bipolar cell input mechanisms in giant danio. I. Electroretinographic analysis.
Topics: Aminobutyrates; Anesthetics, Local; Animals; Aspartic Acid; Cyclopentanes; Dose-Response Relationship, Radiation; Drug Interactions; Electroretinography; Excitatory Amino Acid Agonists; GABA Antagonists; Glycine; Glycine Agents; Neurons; Photic Stimulation; Picrotoxin; Quinoxalines; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Retinal Rod Photoreceptor Cells; Strychnine; Synaptic Transmission; Tetrodotoxin; Visual Pathways; Zebrafish | 2005 |
Retroinhibition of presynaptic Ca2+ currents by endocannabinoids released via postsynaptic mGluR activation at a calyx synapse.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Amino Acids; Animals; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Endocannabinoids; Evoked Potentials, Auditory, Brain Stem; Glycine; Ion Transport; Morpholines; Naphthalenes; Nerve Endings; Patch-Clamp Techniques; Picrotoxin; Piperidines; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols; Scopolamine; Synaptic Transmission; Xanthenes | 2004 |
Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cognition Disorders; Crosses, Genetic; Dentate Gyrus; Disease Models, Animal; Down Syndrome; Evoked Potentials; Female; GABA-A Receptor Antagonists; Gene Dosage; Glycine; Hippocampus; Long-Term Potentiation; Magnesium; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Mutant Strains; Patch-Clamp Techniques; Picrotoxin; Presynaptic Terminals; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Species Specificity; Trisomy | 2004 |
Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons.
Topics: Animals; Brimonidine Tartrate; Cell Survival; Cerebral Cortex; Glycine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Nerve Growth Factor; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Repressor Proteins; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2005 |
Local calcium transients regulate the spontaneous motility of dendritic filopodia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Animals, Newborn; Boron Compounds; Calcium; Calcium Signaling; Cell Movement; Cells, Cultured; Dendrites; Diagnostic Imaging; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Hippocampus; Immunohistochemistry; In Vitro Techniques; Indoles; Pseudopodia; Pyramidal Cells; Pyridazines; Quinoxalines; Rats; Synapses; Time Factors | 2005 |
Cellular and subcellular calcium accumulation during glutamate-induced injury in cerebellar granule neurons.
Topics: Age Factors; Alamethicin; Analysis of Variance; Animals; Animals, Newborn; Brain Diseases; Calcium; Calcium Isotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Count; Cell Death; Cell Fractionation; Cells, Cultured; Cerebellum; Diagnostic Imaging; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Fura-2; Glutamic Acid; Glycine; Hydro-Lyases; Indoles; Intracellular Space; Ionophores; Male; Mitochondria; Neurons; Propidium; Quinoxalines; Rats; Rats, Wistar; Time Factors | 2005 |
Visualization of synaptic Ca2+ /calmodulin-dependent protein kinase II activity in living neurons.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzylamines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fluorescence Resonance Energy Transfer; Gene Expression; Glutamic Acid; Glycine; Hippocampus; Humans; Insecta; Luminescent Proteins; Microscopy, Confocal; Molecular Biology; Mutagenesis, Site-Directed; N-Methylaspartate; Neurons; Phosphorylation; Protein Binding; Quinoxalines; Sodium Channel Blockers; Sulfonamides; Synapses; Tetrodotoxin; Time Factors; Transfection | 2005 |
Cardiovascular response to a group III mGluR agonist in NTS requires NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; Aminobutyrates; Animals; Cardiovascular System; Excitatory Amino Acid Agonists; Glycine; Glycine Agents; Male; Microinjections; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Strychnine | 2005 |
Long-term depression at olfactory nerve synapses.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Calcium; Diagnostic Imaging; Dopamine Antagonists; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Olfactory Bulb; Patch-Clamp Techniques; Quinoxalines; Sodium Channel Blockers; Sulpiride; Synapses; Tetrodotoxin; Time Factors; Valine | 2005 |
AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling.
Topics: Alkaloids; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzophenanthridines; Biotinylation; Blotting, Western; Brain; Brefeldin A; Calcium Channel Blockers; Cell Adhesion; Cells, Cultured; Chlorocebus aethiops; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation; Glycine; In Vitro Techniques; Integrin alphaVbeta3; Mitogen-Activated Protein Kinase Kinases; Neurons; Nifedipine; Paxillin; Phenanthridines; Phosphoproteins; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, AMPA; src-Family Kinases; Time Factors; Transfection; Valine | 2005 |
Serum differentially modifies the transcription and translation of NMDAR subunits in retinal neurons.
Topics: Animals; Chick Embryo; Excitatory Amino Acid Antagonists; Genistein; Glycine; Neurons; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Subunits; Quinoxalines; Receptor, trkA; Receptors, N-Methyl-D-Aspartate; Retina; Serum; Transcription, Genetic | 2008 |
The role of different glutamate receptors in the mediation of glutamate-evoked excitation of red nucleus neurons after simulated microgravity in rat.
Topics: Animals; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hindlimb Suspension; Microinjections; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Red Nucleus; Stimulation, Chemical; Weightlessness Simulation | 2008 |
Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Newborn; Biophysics; Brimonidine Tartrate; Calcium; Calcium Signaling; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Neural Pathways; Neuronal Plasticity; Norepinephrine; Patch-Clamp Techniques; Phosphinic Acids; Piperidines; Propanolamines; Purinergic P1 Receptor Antagonists; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synapses; Xanthines | 2009 |
Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system.
Topics: Analgesics; Animals; Binding Sites; Glycine; Glycine Agents; Lidocaine; Organophosphonates; Pain; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Serine; Spinal Cord; Substrate Specificity; Synaptic Transmission | 2009 |
Long-term potentiation of the responses to parallel fiber stimulation in mouse cerebellar cortex in vivo.
Topics: Animals; Benzoates; Biophysics; Cerebellar Cortex; Diagnostic Imaging; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine; Long-Term Potentiation; Male; Mice; Mice, Inbred Strains; Nerve Fibers; Optics and Photonics; Purkinje Cells; Pyridazines; Quinoxalines | 2009 |
Munc13-2 differentially affects hippocampal synaptic transmission and plasticity.
Topics: Animals; Animals, Newborn; Calcium; Cyclopropanes; Dipeptides; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Long-Term Potentiation; Mice; Mice, Knockout; Mossy Fibers, Hippocampal; Nerve Tissue Proteins; Neuronal Plasticity; Patch-Clamp Techniques; Pyridazines; Quinoxalines; Synapses | 2010 |
Negative shift in the glycine reversal potential mediated by a Ca2+- and pH-dependent mechanism in interneurons.
Topics: Action Potentials; Animals; Animals, Newborn; Benzopyrans; Bicarbonates; Biophysics; Calcium; Chlorides; Cochlear Nucleus; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; HEPES; Hydrogen-Ion Concentration; In Vitro Techniques; Interneurons; Mice; Mice, Inbred ICR; Models, Biological; Patch-Clamp Techniques; Quinoxalines; Sodium Channel Blockers; Sodium-Bicarbonate Symporters; Tetrodotoxin; Time Factors | 2009 |
A glycine site-specific NMDA receptor antagonist protects retina ganglion cells from ischemic injury by modulating apoptotic cascades.
Topics: Animals; Apoptosis; Cytoprotection; Eye Proteins; Frozen Sections; Gene Expression Regulation; Glycine; In Situ Nick-End Labeling; Ischemia; Male; Microscopy, Confocal; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Retinal Ganglion Cells | 2010 |
Ventrolateral medulla mechanisms involved in cardiorespiratory responses to central chemoreceptor activation in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Chemoreceptor Cells; Excitatory Amino Acid Antagonists; Glycine; Hypercapnia; Hypertension; Male; Medulla Oblongata; Models, Neurological; Muscimol; Phrenic Nerve; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Respiratory Physiological Phenomena; Sodium Cyanide; Splanchnic Nerves; Vagotomy | 2011 |
Parasagittally aligned, mGluR1-dependent patches are evoked at long latencies by parallel fiber stimulation in the mouse cerebellar cortex in vivo.
Topics: Animals; Benzoates; Calcium; Cerebellar Cortex; Electric Stimulation; Estrenes; Evoked Potentials; Glycine; Long-Term Potentiation; Male; Mice; Mice, Inbred Strains; Models, Animal; Nerve Fibers; Purkinje Cells; Pyrrolidinones; Quinoxalines; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Ryanodine; Valine | 2011 |
Network oscillations in rod-degenerated mouse retinas.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Age Factors; Animals; Carbenoxolone; Cyclooxygenase Inhibitors; Disease Models, Animal; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Gap Junctions; Glutamic Acid; Glycine; In Vitro Techniques; Light; Male; Meclofenamic Acid; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Neurologic Mutants; Nerve Net; Neural Inhibition; Periodicity; Pyridazines; Quinoxalines; Retinal Degeneration; Retinal Rod Photoreceptor Cells; Sodium Channel Blockers; Statistics as Topic; Tetrodotoxin | 2011 |
Contribution of excitatory amino acid receptors of the retrotrapezoid nucleus to the sympathetic chemoreflex in rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Benzoates; Excitatory Amino Acid Antagonists; Glycine; Hypercapnia; Male; Phrenic Nerve; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Respiratory Center; Splanchnic Nerves | 2011 |
Dynamic metabolic response of mice to acute mequindox exposure.
Topics: Amino Acids; Animals; Anti-Bacterial Agents; Blood Glucose; Citric Acid Cycle; Female; Glycine; Hippurates; Liver; Metabolome; Methylamines; Mice; Principal Component Analysis; Quinoxalines | 2011 |
Glycine exerts dual roles in ischemic injury through distinct mechanisms.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain Ischemia; Dose-Response Relationship, Drug; Glucose; Glycine; Hippocampus; Hypoxia, Brain; Infarction, Middle Cerebral Artery; Long-Term Potentiation; Male; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Viruses | 2012 |
The functional role of ascending nociceptive control in defensive behavior.
Topics: Animals; Benzoates; Excitatory Amino Acid Antagonists; Glycine; Immobility Response, Tonic; Male; Motor Activity; Neural Pathways; Nociception; Nucleus Accumbens; Pain; Quinoxalines; Rats; Rats, Wistar; Somatostatin | 2012 |
Relationship between increase in astrocytic GLT-1 glutamate transport and late-LTP.
Topics: Alanine Transaminase; Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Biophysics; Biotinylation; Cells, Cultured; Colforsin; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Excitatory Postsynaptic Potentials; Flow Cytometry; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Indoles; Kainic Acid; Long-Term Potentiation; Male; Neurons; Protein Transport; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Tetrodotoxin; Valine | 2012 |
LTP requires a unique postsynaptic SNARE fusion machinery.
Topics: Animals; Animals, Newborn; Biophysics; Cells, Cultured; Electric Stimulation; Excitatory Amino Acid Antagonists; Exocytosis; Gene Transfer Techniques; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Membrane Fusion; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Protein Binding; Qa-SNARE Proteins; Quinoxalines; Receptors, AMPA; Receptors, Transferrin; SNARE Proteins; Syntaxin 1; Vesicle-Associated Membrane Protein 2; Vesicular Transport Proteins | 2013 |
Dopamine triggers heterosynaptic plasticity.
Topics: Analysis of Variance; Animals; Benzoates; Channelrhodopsins; Cocaine; Dopamine; Dopamine Uptake Inhibitors; Electric Stimulation; GABAergic Neurons; Genetic Vectors; Glycine; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Long-Term Synaptic Depression; Male; Nucleus Accumbens; Optogenetics; Phosphinic Acids; Photic Stimulation; Propanolamines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Synapses; Time Factors; Transduction, Genetic; Tyrosine 3-Monooxygenase; Ventral Tegmental Area | 2013 |
Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain; Calcium; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Glycogen; Hydrogen-Ion Concentration; Hypoglycemia; Kynurenic Acid; Lactic Acid; Leukoencephalopathies; Mice; Mice, Inbred C57BL; Optic Nerve Injuries; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2014 |
N-oxide reduction of quinoxaline-1,4-dioxides catalyzed by porcine aldehyde oxidase SsAOX1.
Topics: Aldehyde Oxidase; Amino Acid Sequence; Amino Acid Substitution; Animals; Catalysis; Circular Dichroism; Cloning, Molecular; Female; Glycine; Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Quinoxalines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sus scrofa; Threonine | 2014 |
Postsynaptic FMRP promotes the pruning of cell-to-cell connections among pyramidal neurons in the L5A neocortical network.
Topics: Animals; Animals, Newborn; Cell Communication; Disease Models, Animal; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Glycine; Glycine Agents; Green Fluorescent Proteins; In Vitro Techniques; Male; Mice; Mice, Transgenic; Neocortex; Nerve Net; Pyramidal Cells; Quinoxalines; Synapses | 2014 |
Concurrent antagonism of NMDA and AMPA receptors in the ventral tegmental area reduces the expression of conditioned approach learning in rats.
Topics: Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Kynurenic Acid; Male; Quinoxalines; Rats, Long-Evans; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Reward; Ventral Tegmental Area | 2016 |
Identification of potential Gly/NMDA receptor antagonists by cheminformatics approach: a combination of pharmacophore modelling, virtual screening and molecular docking studies.
Topics: Binding Sites; Computer Simulation; Drug Discovery; Glycine; Models, Molecular; Molecular Docking Simulation; Quantitative Structure-Activity Relationship; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Reproducibility of Results | 2016 |
Spectral and Kinetic Study of 3-Methylquinoxalin-2-ones Photoreduced by Amino Acids: N-Phenylglycine Radical Chain Reactions and N-Acetyltryptophan Decarboxylation.
Topics: Amino Acids; Decarboxylation; Glycine; Ketones; Kinetics; Light; Oxidation-Reduction; Quinoxalines; Tryptophan | 2016 |
The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning.
Topics: Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Learning; Long-Term Potentiation; Long-Term Synaptic Depression; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuronal Plasticity; Peptide Fragments; Protein Domains; Quinoxalines; Receptors, AMPA; Sodium Channel Blockers; Synapses; Tetrodotoxin; Valine | 2018 |
Antiviral (Hepatitis C Virus) Drug-Drug Interaction Leading to Dramatic Underestimation of Liver Function With 99mTc-Mebrofenin Hepatobiliary Scintigraphy.
Topics: Adult; Amides; Aniline Compounds; Antiviral Agents; Benzofurans; Carbamates; Cyclopropanes; Drug Interactions; Female; Glycine; Hepacivirus; Humans; Imidazoles; Imino Acids; Liver Failure; Organotechnetium Compounds; Quinoxalines; Radionuclide Imaging; Radiopharmaceuticals; Sulfonamides | 2020 |
Mild microwave ablation combined with HSP90 and TGF‑β1 inhibitors enhances the therapeutic effect on osteosarcoma.
Topics: Animals; Apoptosis; Benzamides; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Glycine; HSP90 Heat-Shock Proteins; Humans; Imidazoles; Indazoles; Microwaves; Osteosarcoma; Quinoxalines; Rabbits; Radiofrequency Ablation; Transforming Growth Factor beta1; Tumor Burden | 2020 |
Characterization of glyphosate and quizalofop-p-ethyl multiple resistance in Eleusine indica.
Topics: 3-Phosphoshikimate 1-Carboxyvinyltransferase; Acetyl-CoA Carboxylase; China; Eleusine; Gene Expression Regulation, Plant; Glycine; Glyphosate; Herbicide Resistance; Herbicides; Mutation; Propionates; Quinoxalines | 2021 |
Effect of Acrolein, a Lipid Oxidation Product, on the Formation of the Heterocyclic Aromatic Amine 2-Amino-3,8-dimethylimidazo[4,5-
Topics: Acrolein; Amines; Animals; Creatinine; Glucose; Glycine; Lipids; Quinoxalines; Salmon | 2022 |