quinoxalines has been researched along with echinomycin in 74 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (66.22) | 18.7374 |
| 1990's | 12 (16.22) | 18.2507 |
| 2000's | 9 (12.16) | 29.6817 |
| 2010's | 4 (5.41) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bazhanov, VS; Berdnikova, VV; Dudnik, IuV; Gol'dberg, LE; Shepelevtseva, NG | 1 |
| Costantino, P; De Santis, P; Ughetto, G | 1 |
| Lee, JS; Waring, MJ | 1 |
| Gauvreau, DJ; Lee, JS; Sutherland, IA | 1 |
| Ughetto, G; Waring, MJ | 1 |
| Wakelin, SP; Waring, MJ | 1 |
| Chen, WY; Hsu, ML; Olsen, RK | 1 |
| Lee, JS; Wakelin, LP; Waring, MJ | 1 |
| Waring, MJ | 2 |
| Alfredson, TV; Maki, AH; Waring, MJ | 1 |
| Adelson, MD; Baker, VV; Barnhill, DR; Blessing, JA; Muss, HB | 1 |
| Alfredson, TV; Maki, AH | 1 |
| Fox, KR; Kentebe, E | 1 |
| Blessing, JA; Malfetano, J; Muss, HB | 1 |
| Crothers, DM; Dean, D; Phillips, DR; White, RJ | 1 |
| Adaskaveg, ME; Alfredson, TV; Excoffier, JL; Maki, AH; Waring, MJ | 1 |
| Konishi, M; Nishiyama, Y; Ohbayashi, M; Ohkusa, N; Oki, T; Sugawara, K; Toda, S; Yamamoto, H | 1 |
| Takusagawa, F | 1 |
| McLean, MJ; Seela, F; Waring, MJ | 1 |
| Gao, XL; Patel, DJ | 2 |
| Feigon, J; Gilbert, DE; van Boom, JH; van der Marel, GA | 1 |
| Clark, GM; Coltman, CA; Hersh, M; Kuhn, JG; Melink, T; Von Hoff, DD; Weiss, GR | 1 |
| Cullen, WP; Huang, LH; Jefferson, MT; Maeda, H; Pacey, MS; Rance, MJ; Ruddock, JC; Tone, J; Whipple, EB | 1 |
| Dervan, PB; Mendel, D | 1 |
| McLean, MJ; Waring, MJ | 1 |
| Jeppesen, C; Nielsen, PE | 1 |
| Duncan, JS; Hutchinson, CR; Kinashi, H; Otten, SL | 1 |
| Fox, KR; Low, CM; Waring, MJ | 1 |
| Adams, RL; Rinaldi, A | 1 |
| Baker, LH; Decker, D; Haas, CD; Leichman, CG; Pazdur, R | 1 |
| Gauvreau, D; Swift, IE; Waring, MJ | 1 |
| Drew, HR; Low, CM; Waring, MJ | 2 |
| Blumauerová, M; Cáslavská, J; Cudlín, J; Lipavská, H; Stajner, K; Steinerová, N; Vanĕk, Z | 1 |
| Portugal, J; Waring, MJ | 1 |
| Garrison, J; Macdonald, JS; Marshall, ME | 1 |
| Clagett-Carr, K; Foster, BJ; Grieshaber, CK; Leyland-Jones, B; Plowman, J; Shoemaker, DD; Suffness, M; Trissel, LA | 1 |
| Fox, KR; Waring, MJ | 3 |
| Quigley, GJ; Rich, A; Ughetto, G; van Boom, JH; van der Marel, GA; Wang, AH | 1 |
| Ahlgren, JD; Andrews, WG; Byrne, PJ; Harvey, JH; McFadden, M; Woolley, PV | 1 |
| Dervan, PB; Van Dyke, MM | 1 |
| Crooke, ST; Huang, CH; Prestayko, AW | 1 |
| Gauvreau, D; Waring, MJ | 3 |
| Lathan, B; Von Hoff, DD | 1 |
| Formica, JV; Waring, MJ | 1 |
| Cornish, A; Nolan, RD; Waring, MJ | 1 |
| Bogden, AE; Cobb, WR; Griffin, TW; Kelton, DE; LePage, DJ; Reich, SD | 1 |
| Doddrell, DM; Fox, KR; Reid, DG; Williams, DH | 1 |
| Shafer, RH; Waring, MJ | 1 |
| Fox, KR; Gauvreau, D; Goodwin, DC; Waring, MJ | 1 |
| Fox, KR; Wakelin, LP; Waring, MJ | 1 |
| Addess, KJ; Feigon, J | 1 |
| Alvarez-Builla, J; Burgos, C; Gago, F; Gallego, J; Luque, FJ; Orozco, M; Rodrigo, MM | 1 |
| Heine, A; Jones, PG; Paulus, E; Pohl, E; Schmidt-Bäse, K; Sheldrick, GM; Waring, MJ | 1 |
| Takusagawa, F; Takusagawa, HL | 1 |
| Bailly, C; Møllegaard, NE; Nielsen, PE; Waring, MJ | 1 |
| Bailly, C; Crow, S; Minnock, A; Waring, MJ | 1 |
| KATAGIRI, K; YOKOZAWA, S; YOSHIDA, T | 1 |
| Kim, SK; Kim, YB; Kim, YH; Park, JY | 1 |
| Jewiarz, J; Keller, U; Laubinger, W; Pfennig, F; Schauwecker, F; Schlumbohm, W; Schmoock, G | 1 |
| Gago, F; Luque, FJ; Marco, E; Negri, A | 1 |
| Koketsu, K; Oguri, H; Oikawa, H; Watanabe, K | 2 |
| Dawson, S; Malkinson, JP; Paumier, D; Searcey, M | 1 |
| Hirose, Y; Minami, A; Nakamura, T; Oguri, H; Oikawa, H; Watanabe, K | 1 |
| Eriksson, LA; Jarikote, DV; Jiang, T; Li, W; Murphy, PV | 1 |
| Deng, Z; Kong, L; Lei, X; Lin, B; Liu, Q; Yin, J; You, D; Zhang, C; Zhu, T | 1 |
| Bibby, J; Fang, M; Hotta, K; Keegan, RM; Kim, CY; Lian, M; Ranganathan, S; Rigden, DJ; Sato, M; Watanabe, K; Winn, MD | 1 |
4 review(s) available for quinoxalines and echinomycin
| Article | Year |
|---|---|
Echinomycin.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; DNA, Bacterial; DNA, Neoplasm; Echinomycin; Escherichia coli; Humans; In Vitro Techniques; Micrococcus; Molecular Conformation; Quinoxalines; Structure-Activity Relationship | 1992 |
Antitumour drug-DNA interactions: NMR studies of echinomycin and chromomycin complexes.
Topics: Antineoplastic Agents; Binding Sites; Biophysical Phenomena; Biophysics; Chromomycins; DNA; Echinomycin; Magnetic Resonance Spectroscopy; Molecular Conformation; Quinoxalines | 1989 |
Echinomycin: the first bifunctional intercalating agent in clinical trials.
Topics: Animals; Clinical Trials as Topic; Cross-Linking Reagents; DNA; Dogs; Drug Evaluation; Echinomycin; Humans; Lethal Dose 50; Mice; Neoplasms, Experimental; Quinoxalines | 1985 |
Bisintercalator natural products with potential therapeutic applications: isolation, structure determination, synthetic and biological studies.
Topics: Biological Products; Depsipeptides; DNA; Echinomycin; Intercalating Agents; Peptides; Peptides, Cyclic; Quinolines; Quinoxalines | 2007 |
2 trial(s) available for quinoxalines and echinomycin
| Article | Year |
|---|---|
Echinomycin (NSC 526417) in advanced ovarian cancer. A phase II trial of the Gynecologic Oncology Group.
Topics: Adult; Aged; Carcinoma; Drug Evaluation; Echinomycin; Female; Humans; Infusions, Intravenous; Middle Aged; Multicenter Studies as Topic; Neoplasm Recurrence, Local; Ovarian Neoplasms; Quinoxalines; Remission Induction | 1990 |
Echinomycin: the first bifunctional intercalating agent in clinical trials.
Topics: Animals; Clinical Trials as Topic; Cross-Linking Reagents; DNA; Dogs; Drug Evaluation; Echinomycin; Humans; Lethal Dose 50; Mice; Neoplasms, Experimental; Quinoxalines | 1985 |
69 other study(ies) available for quinoxalines and echinomycin
| Article | Year |
|---|---|
[Study of the toxicity and antiblastoma activity of antibiotics echinomycin and 6270 in complexes with DNA].
Topics: Animals; Antibiotics, Antineoplastic; DNA; Drug Therapy, Combination; Echinomycin; Lymphoma, Non-Hodgkin; Mice; Quinoxalines; Sarcoma, Experimental | 1977 |
Circular dichroism studies on the echinomycin--DNA complex.
Topics: Circular Dichroism; DNA; Echinomycin; Hydrogen Bonding; Methanol; Molecular Conformation; Nucleic Acid Conformation; Quinoxalines; Solvents; Water | 1978 |
Bifunctional intercalation and sequence specificity in the binding of quinomycin and triostin antibiotics to deoxyribonucleic acid.
Topics: Anti-Bacterial Agents; Base Sequence; Chemical Phenomena; Chemistry; DNA; DNA, Circular; Echinomycin; Polynucleotides; Quinoxalines | 1978 |
Separation of quinoxaline antibiotics by coil planet centrifugation.
Topics: Anti-Bacterial Agents; Centrifugation; Chromatography; Echinomycin; Quinoxalines | 1978 |
Conformation of the deoxyribonucleic acid-binding peptide antibiotic echinomycin based on energy calculations.
Topics: Chemical Phenomena; Chemistry; DNA; Echinomycin; Models, Molecular; Molecular Conformation; Nuclear Energy; Quinoxalines; Thermodynamics | 1977 |
The binding of echinomycin to deoxyribonucleic acid.
Topics: Binding Sites; DNA; DNA, Bacterial; DNA, Circular; Echinomycin; Osmolar Concentration; Poly C; Poly dA-dT; Poly G; Poly I-C; Poly U; Quinoxalines; Temperature; Ultracentrifugation; Viscosity | 1976 |
Synthesis of a model depsipeptide lactone related to the quinoxaline antibiotics.
Topics: Echinomycin; Lactones; Methods; Models, Chemical; Peptides; Quinoxalines | 1975 |
A solvent-partition method for measuring the binding of drugs to DNA. Application to the quinoxaline antibiotics echinomycin and triostin A.
Topics: Animals; Anti-Bacterial Agents; Binding Sites; Cattle; DNA; Echinomycin; Kinetics; Nucleic Acid Conformation; Quinoxalines; Spectrophotometry, Ultraviolet; Thymus Gland | 1975 |
Conformational heterogeneity of quinoxaline peptides in solution.
Topics: 4-Quinolones; Amino Acid Sequence; Anti-Infective Agents; Echinomycin; Molecular Sequence Data; Oligopeptides; Protein Conformation; Quinoxalines; Software; Solutions | 1991 |
Phosphorescence and optically detected magnetic resonance studies of echinomycin-DNA complexes.
Topics: Base Sequence; DNA; Echinomycin; Kinetics; Luminescent Measurements; Magnetic Resonance Spectroscopy; Models, Chemical; Oligonucleotides; Quinoxalines; Solutions; Temperature; X-Ray Diffraction | 1990 |
Echinomycin binding to the sequence CG(AT)nCG alters the structure of the central AT region.
Topics: Base Sequence; Binding Sites; Densitometry; Deoxyribonuclease I; Diethyl Pyrocarbonate; DNA; Echinomycin; Micrococcal Nuclease; Molecular Sequence Data; Nucleic Acid Conformation; Quinoxalines | 1990 |
Echinomycin (NSC 526417) in squamous-cell carcinoma of the cervix. A phase II trial of the Gynecologic Oncology Group.
Topics: Adult; Aged; Carcinoma, Squamous Cell; Drug Evaluation; Echinomycin; Female; Humans; Middle Aged; Nausea; Neoplasm Metastasis; Neoplasm Recurrence, Local; Quinoxalines; Uterine Cervical Neoplasms | 1990 |
Monte-Carlo simulation of multisite echinomycin-DNA interactions detected by in vitro transcription analysis.
Topics: Base Sequence; Binding Sites; Computer Simulation; DNA; Echinomycin; Molecular Sequence Data; Monte Carlo Method; Quinoxalines; Transcription, Genetic | 1990 |
Liquid chromatographic investigation of quinoxaline antibiotics and their analogues by means of ultraviolet diode-array detection.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Echinomycin; Quinoxalines; Ultraviolet Rays | 1990 |
Quinaldopeptin, a novel antibiotic of the quinomycin family.
Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Bacteria; Echinomycin; Fungi; Humans; Leukemia P388; Leukemia, Experimental; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Quinoxalines; Spectrum Analysis; Streptomycetaceae; Tumor Cells, Cultured | 1990 |
The role of the cyclic depsipeptide rings in antibiotics.
Topics: Anti-Bacterial Agents; Base Composition; Base Sequence; Dactinomycin; DNA; Echinomycin; Hydrogen Bonding; Molecular Conformation; Quinoxalines; RNA; Structure-Activity Relationship; Transcription, Genetic | 1985 |
Overview of the interaction between chemotherapeutic agents and DNA.
Topics: Animals; Anti-Bacterial Agents; Base Sequence; Bleomycin; Crystallography; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; Endodeoxyribonucleases; Mitomycins; Models, Molecular; Molecular Conformation; Netropsin; Nucleic Acid Conformation; Quinoxalines | 1986 |
Echinomycin-induced hypersensitivity to osmium tetroxide of DNA fragments incapable of forming Hoogsteen base pairs.
Topics: Aminoglycosides; Anti-Bacterial Agents; Base Composition; Base Sequence; Deoxyribonuclease I; DNA; DNA, Single-Stranded; Echinomycin; Molecular Sequence Data; Molecular Structure; Nucleotide Mapping; Oligodeoxyribonucleotides; Osmium; Osmium Tetroxide; Plasmids; Promoter Regions, Genetic; Quinoxalines; Terminator Regions, Genetic; Tubercidin | 1989 |
Unstable Hoogsteen base pairs adjacent to echinomycin binding sites within a DNA duplex.
Topics: Base Composition; Binding Sites; DNA; Echinomycin; Magnetic Resonance Spectroscopy; Molecular Structure; Nucleic Acid Conformation; Quinoxalines; Temperature | 1989 |
Phase I trial of echinomycin (NSC 526417), a bifunctional intercalating agent, administered by 24-hour continuous infusion.
Topics: Adult; Aged; Drug Evaluation; Echinomycin; Female; Humans; Infusions, Intravenous; Liver Function Tests; Male; Middle Aged; Nausea; Neoplasms; Platelet Count; Quinoxalines; Thrombocytopenia; Vomiting | 1989 |
UK-63,052 complex, new quinomycin antibiotics from Streptomyces braegensis subsp. japonicus; taxonomy, fermentation, isolation, characterisation and antimicrobial activity.
Topics: Anti-Bacterial Agents; Echinomycin; Fermentation; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Quinoxalines; Soil Microbiology; Spectrophotometry; Streptomyces | 1989 |
Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA.
Topics: Base Composition; Binding Sites; Deoxyribonuclease I; Diethyl Pyrocarbonate; DNA; Echinomycin; Edetic Acid; Purines; Quinoxalines | 1987 |
Chemical probes reveal no evidence of Hoogsteen base pairing in complexes formed between echinomycin and DNA in solution.
Topics: Acetaldehyde; Alkylating Agents; Base Composition; Base Sequence; Binding Sites; Diethyl Pyrocarbonate; DNA; Echinomycin; Hydrogen-Ion Concentration; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Osmium Tetroxide; Palladium; Quinoxalines; Sulfuric Acid Esters; Tubercidin | 1988 |
Detection of intercalation-induced changes in DNA structure by reaction with diethyl pyrocarbonate or potassium permanganate. Evidence against the induction of Hoogsteen base pairing by echinomycin.
Topics: Base Composition; Base Sequence; Diethyl Pyrocarbonate; DNA; Echinomycin; Formates; Intercalating Agents; Plasmids; Potassium Permanganate; Quinoxalines; Structure-Activity Relationship | 1988 |
NMR studies of echinomycin bisintercalation complexes with d(A1-C2-G3-T4) and d(T1-C2-G3-A4) duplexes in aqueous solution: sequence-dependent formation of Hoogsteen A1.T4 and Watson--Crick T1.A4 base pairs flanking the bisintercalation site.
Topics: Base Sequence; Echinomycin; Intercalating Agents; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Quinoxalines; Solutions | 1988 |
Frequent loss and restoration of antibiotic production by Streptomyces lasaliensis.
Topics: 4-Butyrolactone; Conjugation, Genetic; Echinomycin; Genes; Genes, Bacterial; Growth Substances; Lasalocid; Mutation; Plasmids; Protoplasts; Quinoxalines; Recombination, Genetic; Streptomyces | 1988 |
DNA sequence selectivity of three biosynthetic analogues of the quinoxaline antibiotics.
Topics: Anti-Bacterial Agents; Base Composition; Base Sequence; Binding Sites; Deoxyribonuclease I; DNA; Echinomycin; Molecular Sequence Data; Nucleotide Mapping; Quinoxalines; Structure-Activity Relationship | 1986 |
Effect of echinomycin on DNA methylation.
Topics: Animals; Cell Division; DNA; DNA (Cytosine-5-)-Methyltransferases; Echinomycin; L Cells; Methylation; Mice; Quinoxalines | 1987 |
Phase I study of echinomycin.
Topics: Carcinoma; Echinomycin; Humans; Intercalating Agents; Quinoxalines | 1987 |
Studies on antibiotic biosynthesis by protoplasts and resting cells of Streptomyces echinatus. Part II. Effect of chromophore precursors.
Topics: Amino Acids; Autoradiography; Chromatography, Thin Layer; Echinomycin; Protoplasts; Quinoxalines; Streptomyces; Tryptophan | 1986 |
Echinomycin and distamycin induce rotation of nucleosome core DNA.
Topics: Animals; Base Sequence; Chickens; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; In Vitro Techniques; Nucleic Acid Conformation; Nucleosomes; Plasmids; Pyrroles; Quinoxalines | 1986 |
Production of quinomycin A in Streptomyces lasaliensis.
Topics: Echinomycin; Mutation; Quinoxalines; Streptomyces; Temperature | 1987 |
Interaction of nucleosome core particles with distamycin and echinomycin: analysis of the effect of DNA sequences.
Topics: Animals; Base Sequence; Chickens; Deoxyribonuclease I; Distamycins; DNA; Echinomycin; Erythrocytes; Histones; Nucleosomes; Plasmids; Pyrroles; Quinoxalines; Xenopus | 1987 |
Unusual skin reaction to echinomycin.
Topics: Echinomycin; Humans; Male; Middle Aged; Multiple Myeloma; Quinoxalines; Skin Ulcer | 1987 |
Kinetic evidence that echinomycin migrates between potential DNA binding sites.
Topics: Base Sequence; Binding Sites; DNA; Echinomycin; Kinetics; Quinoxalines | 1985 |
A comparison of the structure of echinomycin and triostin A complexed to a DNA fragment.
Topics: Base Sequence; Chemical Phenomena; Chemistry; Crystallization; DNA; Echinomycin; Models, Molecular; Quinoxalines | 1985 |
Phase I study of echinomycin administered on an intermittent bolus schedule.
Topics: Adult; Aged; Alanine Transaminase; Anaphylaxis; Aspartate Aminotransferases; Droperidol; Drug Administration Schedule; Drug Evaluation; Echinomycin; Female; Hematologic Diseases; Humans; Male; Middle Aged; Nausea; Neoplasms; Quinoxalines | 1985 |
Echinomycin binding sites on DNA.
Topics: Base Sequence; Binding Sites; DNA; DNA Restriction Enzymes; Echinomycin; Electrophoresis; Escherichia coli; Plasmids; Quinoxalines | 1984 |
Bifunctional intercalation of antitumor antibiotics BBM-928A and echinomycin with deoxyribonucleic acid. Effects of intercalation on deoxyribonucleic acid degradative activity of bleomycin and phleomycin.
Topics: Animals; Antibiotics, Antineoplastic; Bacteriophages; Bleomycin; Cattle; Chemical Phenomena; Chemistry; DNA; DNA, Single-Stranded; DNA, Superhelical; DNA, Viral; Echinomycin; Phleomycins; Pseudomonas; Quinolines; Quinoxalines; Spectrometry, Fluorescence; Thymus Gland | 1982 |
Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences.
Topics: Base Composition; Base Sequence; Chemical Phenomena; Chemistry; Deoxyribonuclease I; DNA, Bacterial; Echinomycin; Endodeoxyribonucleases; Escherichia coli; Quinoxalines; RNA-Directed DNA Polymerase | 1984 |
Stopped-flow kinetic studies on the interaction between echinomycin and DNA.
Topics: Animals; Cattle; Chemical Phenomena; Chemistry; DNA; DNA, Bacterial; Echinomycin; Kinetics; Micrococcus; Poly dA-dT; Polydeoxyribonucleotides; Quinoxalines; Structure-Activity Relationship; Thymus Gland | 1984 |
Studies on antibiotic biosynthesis by protoplasts and resting cells of Streptomyces echinatus. Part I. The synthesis of echinomycin.
Topics: Amino Acids; Buffers; Echinomycin; Energy Metabolism; Protoplasts; Quinoxalines; Streptomyces; Time Factors | 1984 |
Directed biosynthesis of novel derivatives of echinomycin. II. Purification and structure elucidation.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Echinomycin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Quinoxalines; Streptomyces | 1984 |
Cytotoxic activity of echinomycin in a human tumor cloning system.
Topics: Cell Survival; Cells, Cultured; Echinomycin; Female; Humans; Male; Neoplasms; Quinoxalines; Tumor Stem Cell Assay | 1984 |
Effect of phosphate and amino acids on echinomycin biosynthesis by Streptomyces echinatus.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Culture Media; Echinomycin; Hydrogen-Ion Concentration; Nitrogen; Phosphates; Quinoxalines; Streptomyces | 1983 |
Conversion of triostins to quinomycins by protoplasts of Streptomyces echinatus.
Topics: Anti-Bacterial Agents; Carbon Radioisotopes; Echinomycin; Kinetics; Protoplasts; Quinoxalines; Streptomyces; Sulfur Radioisotopes | 1983 |
Activity of two phase I drugs N-methylformamide (NSC-3051) and Echinomycin (NSC-526417) against fresh surgical explants of human tumors in the 6-day subrenal capsule (SRC) assay.
Topics: Animals; Cyclophosphamide; Drug Evaluation; Echinomycin; Female; Formamides; Humans; Mice; Neoplasms; Quinoxalines; Transplantation, Heterologous | 1983 |
A 15N nuclear magnetic resonance study of the biosynthesis of quinoxaline antibiotics.
Topics: Echinomycin; Magnetic Resonance Spectroscopy; Nitrogen Isotopes; Quinoxalines; Streptomyces | 1984 |
Directed biosynthesis of novel derivatives of echinomycin by Streptomyces echinatus. I. Effect of exogenous analogues of quinoxaline-2-carboxylic acid on the fermentation.
Topics: Echinomycin; Fermentation; Microbial Sensitivity Tests; Quinoxalines; Streptomyces; Structure-Activity Relationship | 1984 |
DNA bis-intercalation: theoretical analysis, including cooperativity of the interaction of echinomycin analogs with DNA.
Topics: Chemical Phenomena; Chemistry; DNA, Bacterial; Echinomycin; Quinoxalines | 1982 |
Binding of quinoline analogues of echinomycin to deoxyribonucleic acid. Role of the chromophores.
Topics: Base Composition; Chemical Phenomena; Chemistry; DNA; DNA, Bacterial; DNA, Superhelical; DNA, Viral; Echinomycin; Intercalating Agents; Kinetics; Quinoxalines; Spectrometry, Fluorescence; Ultracentrifugation | 1980 |
Kinetics of dissociation of quinoxaline antibiotics from DNA.
Topics: Animals; Anti-Bacterial Agents; Binding Sites; Cattle; DNA; Echinomycin; In Vitro Techniques; Kinetics; Quinoxalines; Structure-Activity Relationship; Thermodynamics | 1981 |
Kinetics of the interaction between echinomycin and deoxyribonucleic acid.
Topics: Base Composition; Chemical Phenomena; Chemistry; DNA; Echinomycin; Kinetics; Osmolar Concentration; Poly dA-dT; Polydeoxyribonucleotides; Quinoxalines; Sodium Dodecyl Sulfate; Spectrophotometry; Temperature | 1981 |
NMR investigation of Hoogsteen base pairing in quinoxaline antibiotic--DNA complexes: comparison of 2:1 echinomycin, triostin A and [N-MeCys3,N-MeCys7] TANDEM complexes with DNA oligonucleotides.
Topics: Anti-Bacterial Agents; Base Composition; Base Sequence; Dinucleoside Phosphates; DNA; Echinomycin; Intercalating Agents; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Quinoxalines; Temperature | 1994 |
DNA sequence-specific reading by echinomycin: role of hydrogen bonding and stacking interactions.
Topics: 2-Aminopurine; Base Composition; Base Sequence; Binding Sites; Chemical Phenomena; Chemistry, Physical; Deoxyribonuclease I; DNA; Echinomycin; Electrochemistry; Hydrogen Bonding; Hypoxanthine; Hypoxanthines; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Quinoxalines; Thermodynamics | 1994 |
Structures of quinoxaline antibiotics.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Base Sequence; Binding Sites; Crystallization; Crystallography, X-Ray; DNA; Echinomycin; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Protein Conformation; Quinoxalines | 1995 |
Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] and d(ACGTAGCTACGT)2:[actinomycin D, (triostin A)2] complexes.
Topics: Crystallization; Crystallography, X-Ray; Dactinomycin; Echinomycin; Macromolecular Substances; Models, Molecular; Molecular Conformation; Molecular Structure; Oligodeoxyribonucleotides; Quinoxalines | 2000 |
Quinoxaline antibiotics enhance peptide nucleic acid binding to double-stranded DNA.
Topics: Adjuvants, Pharmaceutic; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Binding Sites; Diminazene; DNA; Echinomycin; Electrophoresis, Polyacrylamide Gel; Intercalating Agents; Netropsin; Peptide Nucleic Acids; Plicamycin; Quinoxalines | 2000 |
DNA recognition by quinoline antibiotics: use of base-modified DNA molecules to investigate determinants of sequence-specific binding of luzopeptin.
Topics: 2-Aminopurine; Antiprotozoal Agents; Base Pairing; Base Sequence; Binding Sites; Deoxyribonuclease I; DNA; DNA Footprinting; DNA Replication; DNA, Bacterial; Echinomycin; Electrophoresis, Polyacrylamide Gel; Hydrogen Bonding; Hydroxyquinolines; Inosine; Intercalating Agents; Molecular Sequence Data; Molecular Structure; Peptides, Cyclic; Polymerase Chain Reaction; Quinolines; Quinoxalines; Structure-Activity Relationship | 2000 |
Studies on quinoxaline antibiotics. II. Isolation and properties of quinomycins A, B and C.
Topics: Anti-Bacterial Agents; Echinomycin; Quinoxalines | 1961 |
Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues.
Topics: Anti-Bacterial Agents; Apoptosis; Cell Line, Tumor; Echinomycin; Humans; Quinoxalines | 2004 |
Functional cross-talk between fatty acid synthesis and nonribosomal peptide synthesis in quinoxaline antibiotic-producing streptomycetes.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Binding Sites; Carboxylic Acids; Chromatography, Thin Layer; Cloning, Molecular; DNA; Echinomycin; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fatty Acid Synthases; Genome; Kinetics; Lactones; Models, Chemical; Molecular Sequence Data; Peptide Biosynthesis; Peptide Biosynthesis, Nucleic Acid-Independent; Peptides; Plasmids; Protein Binding; Protein Structure, Tertiary; Quinoxalines; Recombinant Proteins; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Streptomyces; Streptomyces lividans; Substrate Specificity; Valine | 2005 |
Role of stacking interactions in the binding sequence preferences of DNA bis-intercalators: insight from thermodynamic integration free energy simulations.
Topics: Base Sequence; Binding Sites; Computer Simulation; CpG Islands; DNA; Echinomycin; Hydrogen Bonding; Intercalating Agents; Quinoxalines; Thermodynamics | 2005 |
Identification and stereochemical assignment of the beta-hydroxytryptophan intermediate in the echinomycin biosynthetic pathway.
Topics: 5-Hydroxytryptophan; Echinomycin; Molecular Structure; Quinoxalines; Stereoisomerism; Streptomyces | 2006 |
Enzymatic macrolactonization in the presence of DNA leading to triostin A analogs.
Topics: Catalysis; Cloning, Molecular; Cyclization; Cysteamine; Dimerization; DNA; Echinomycin; Gene Expression Regulation; Intercalating Agents; Protein Structure, Tertiary; Quinoxalines; Thiolester Hydrolases; Time Factors | 2008 |
Involvement of common intermediate 3-hydroxy-L-kynurenine in chromophore biosynthesis of quinomycin family antibiotics.
Topics: Antibiotics, Antineoplastic; Cloning, Molecular; DNA, Bacterial; Echinomycin; Escherichia coli; Genes, Bacterial; Kynurenic Acid; Kynurenine; Magnetic Resonance Spectroscopy; Multigene Family; Optical Rotation; Peptide Synthases; Polymerase Chain Reaction; Quinoxalines; Spectrometry, Mass, Electrospray Ionization | 2011 |
Towards echinomycin mimetics by grafting quinoxaline residues on glycophane scaffolds.
Topics: Animals; Binding Sites; Cattle; DNA; Echinomycin; Molecular Dynamics Simulation; Nucleic Acid Conformation; Peptidomimetics; Quinoxalines; Spectrometry, Fluorescence; Transition Temperature | 2011 |
In vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan.
Topics: 5-Hydroxytryptophan; Biosynthetic Pathways; Cloning, Molecular; Echinomycin; Enzyme Activation; Genes, Bacterial; Hydroxylation; Multigene Family; Mutation; Open Reading Frames; Peptide Synthases; Phylogeny; Quinoxalines; Streptomyces; Substrate Specificity; Tryptophan Oxygenase | 2013 |
Conversion of a disulfide bond into a thioacetal group during echinomycin biosynthesis.
Topics: Catalysis; Crystallography, X-Ray; Disulfides; Echinomycin; Homocysteine; Hydrogen Bonding; Methionine; Methyltransferases; Protein Structure, Tertiary; Quinoxalines | 2014 |