quinoxalines has been researched along with cyclic gmp in 418 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.24) | 18.7374 |
| 1990's | 97 (23.21) | 18.2507 |
| 2000's | 254 (60.77) | 29.6817 |
| 2010's | 63 (15.07) | 24.3611 |
| 2020's | 3 (0.72) | 2.80 |
| Authors | Studies |
|---|---|
| East, SJ; Garthwaite, J; Southam, E | 1 |
| Gallo, V; Levi, G; Patrizio, M | 1 |
| Oien, TT; Sethy, VH | 1 |
| Okada, D; Shibuki, K | 1 |
| Gallo, V; Giovannini, C; Levi, G | 1 |
| Bullock, GR; Taylor, SG; Weston, AH | 1 |
| Brunner, F; Kukovetz, WR; Stessel, H | 1 |
| Coste, H; Grondin, P | 1 |
| Boulton, CL; Garthwaite, J; Mayer, B; Nielsen, EB; Schmidt, K; Southam, E | 1 |
| Ambrosini, A; Racagni, G | 1 |
| Regunathan, S; Reis, DJ | 1 |
| Bockaert, J; Lafon-Cazal, M; Marin, P; Quignard, JF | 1 |
| Frandsen, A; Griffiths, R; Schousboe, A | 1 |
| Dawson, TM; Dawson, VL; Snyder, SH; Uhl, GR | 1 |
| Boulton, CL; Garthwaite, J; Southam, E | 1 |
| Brunner, F; Mayer, B; Nielsen, EB; Schmidt, K | 1 |
| Cellek, S; Darley-Usmar, VM; Lizasoain, I; Moncada, S; Moro, MA; Radomski, MW; Russel, RJ; Su, Y | 1 |
| Cellek, S; Kasakov, L; Moncada, S | 1 |
| McCaslin, PP; Oh, S | 1 |
| Fedele, E; Raiteri, M | 1 |
| Charles, SL; Garthwaite, J; Southam, E | 1 |
| Fedele, E; Jin, Y; Raiteri, M; Varnier, G | 1 |
| Graham, A; Owen, JS; Riddell, DR | 1 |
| Loweth, AC; Morgan, NG; Scarpello, JH; Williams, GT | 1 |
| Drewett, JG; Herzig, TC; Knych, ET; Olson, LJ | 1 |
| Brown, JC; Burns, DM; Dykes, EL; Flitney, FW; Hirst, DG; Kennovin, GD; Ruddock, MW | 1 |
| Branka, JE; Jarry, A; Laboisse, CL; Vallette, G | 1 |
| Gage, AT; Reyes, M; Stanton, PK | 1 |
| Bloch, DB; Bloch, KD; Filippov, G | 1 |
| Ichinose, M; Sawada, M; Stefano, GB | 1 |
| Chu, HP; Etgen, AM | 1 |
| Alam, J; Choi, AM; Cook, JL; Hartsfield, CL | 1 |
| Franck, H; Sanders, KM; Shuttleworth, CW; Sweeney, KM | 1 |
| Conti, A; Fedele, E; Raiteri, M | 1 |
| Fedele, E; Raiteri, M; Varnier, G | 1 |
| Morris, R; Thippeswamy, T | 1 |
| Campbell, WB; Jin, MW; Li, PL | 1 |
| Cantabrana, B; Hidalgo, A; Menéndez Antolin, L; Pérez Vallina, JR; Sánchez, M | 1 |
| Iadecola, C; Yang, G | 1 |
| Canning, BJ; Fischer, A | 1 |
| Cohen, A; Fouty, B; Komalavilas, P; Lincoln, TM; McMurtry, IF; Muramatsu, M; Rodman, DM | 1 |
| Nawy, S; Stanton, PK; Wexler, EM | 1 |
| Katusic, ZS; Onoue, H | 1 |
| Anwyl, R; Rowan, MJ; Wang, Y; Wu, J | 1 |
| Barbeito, L; Beckman, JS; Cornwell, TL; Estévez, AG; Radi, R; Spear, N; Thompson, JA | 1 |
| Ali, IS; Clanachan, AS; Finegan, BA; Gandhi, M; Koshal, A | 1 |
| de Vente, J; Hopkins, DA; Markerink-van Ittersum, M; Steinbusch, HW | 1 |
| Anraku, M; Ichinose, M; Sawada, M | 2 |
| Gordge, MP; Hothersall, JS; Noronha-Dutra, AA | 1 |
| Kanadia, RN; Kuo, WN; Mcnabb, M | 1 |
| Bartfai, T; Caltavuturo, C; Consolo, S; Uboldi, MC | 1 |
| Fischer, H; Philippu, A; Prast, H; Tran, MH | 1 |
| Bredt, DS; Morton, DB | 1 |
| Contreras, J; García-Sacristán, A; Hernández, M; López, PG; Prieto, D; Recio, P | 1 |
| Muneoka, Y; Pedder, SM; Walker, RJ | 1 |
| Campbell, WB; Drewett, JG; Hanke, CJ; Myers, CR | 1 |
| Ruiz, E; Tejerina, T | 1 |
| Polte, T; Schröder, H | 1 |
| Goyal, RK; He, XD | 1 |
| Fernández-Tomé, P; Leza, JC; Lizasoain, I; Lorenzo, P; Moro, MA | 2 |
| Hwang, TL; Teng, CM; Wu, CC | 1 |
| Cohen, RA; Griswold, MC; Komalavilas, P; Lincoln, TM; Weisbrod, RM; Yaghoubi, M | 1 |
| Alm, P; Ekström, P; Henningsson, R; Lundquist, I | 1 |
| Brown, AS; Cramer, EM; Darley-Usmar, V; Masse, JM; Moro, MA; Radomski, M | 1 |
| Akashi, C; Matsumura, Y; Mitsutomi, N; Odagiri, J | 1 |
| Frölich, JC; Ikic, M; Raida, M; Tewes, KS; Tsikas, D | 1 |
| Deichmann, PC; Falck, JR; Imig, JD; Inscho, EW; Reddy, KM | 1 |
| Kawana, S; Miyamoto, A; Namiki, A; Ohshika, H; Yamamoto, S | 1 |
| Carvalho, AP; Carvalho, CM; Sequeira, SM | 1 |
| Brown, C; Hassid, A; Pan, X | 1 |
| Belonga, KL; Carter, DB; Im, HK; Im, WB; Jacobsen, EJ; Mickelson, JW; Petke, JD; Sethy, VH; Stelzer, LS; Tang, AH; TenBrink, RE; VonVoigtlander, PF; Zhong, WZ | 1 |
| Dasso, M; Rosenzweig, S; Spielman, AI; Yan, W | 1 |
| Jacklet, JW; Koh, HY | 1 |
| Rehder, V; Van Wagenen, S | 1 |
| De la Lande, IS; Horowitz, JD; Stafford, I | 1 |
| Diamond, J; Sandirasegarane, L | 2 |
| Agulló, L; García-Dorado, D; Inserte, J; Llevadot, J; Paniagua, A; Pyrhonen, P; Soler-Soler, J | 1 |
| Allescher, HD; Fritsch, R; Kurjak, M; Saur, D; Schusdziarra, V | 1 |
| Bicker, G; Wildemann, B | 1 |
| Galle, J; Hatzelmann, A; Hübner, U; Schmidt, HH; Wagner, B; Wanner, C; Zabel, U | 1 |
| D'Angelo, S; Mulè, F; Serio, R | 1 |
| Cunha, FQ; Ferreira, SH; Teixeira, MM | 1 |
| Closs, EI; Förstermann, U; Nawrath, H; Wegener, JW | 1 |
| Alfonzo, MJ; González de Alfonzo, R; Guerra de González, L; Lippo de Bécemberg, I; Misle, A; Napoleón de Herrera, V; Pacheco, G | 1 |
| Catalin, D; Miolan, JP; Niel, JP; Quinson, N | 1 |
| Duszyk, M; Thethi, K | 1 |
| Carlson, EJ; Drewett, JG; Kreklau, EL | 1 |
| Cantoni, O; Clementi, E; Guidarelli, A; Sciorati, C | 1 |
| Budelmann, BU; Tu, Y | 2 |
| Gong, GX; Scholz, PM; Straznicka, M; Tse, J; Weiss, HR; Yan, L | 1 |
| Kawamata, T; Omote, K | 1 |
| Chesnais, JM; Fischmeister, R; Mery, PF | 1 |
| Alonso-Galicia, M; Harder, DR; Hudetz, AG; Roman, RJ; Shen, H | 1 |
| Brown, T; Bunton, D; MacDonald, A; McGrath, JC; Shaw, AM; Tracey, A | 1 |
| Gupte, SA; Phillibert, D; Rupawalla, T; Wolin, MS | 1 |
| Fox-Robichaud, A; Kubes, P; Payne, D | 1 |
| Vaziri, ND; Wang, XQ | 1 |
| Aguilar, E; González, D | 1 |
| Berkels, R; Klaus, W; Roesen, R; Suerhoff, S | 1 |
| Allen, JC; Kahn, AM; Seidel, CL; Zhang, S | 1 |
| Hall, SR; Jhamandas, K; Milne, B; Sullivan, ME | 1 |
| Cocks, TM; Selemidis, S | 1 |
| Baydoun, AR; Edwards, RJ; Mann, GE; Marber, MS; Mockridge, JW; Rakhit, RD; Wyatt, AW | 1 |
| Gordon, JB; Halla, TR; Madden, JA | 1 |
| Liu, XD; Rennard, SI; Romberger, DJ; Skold, CM; Spurzem, JR; Umino, T | 1 |
| Aguirre-Bañuelos, P; Granados-Soto, V | 1 |
| Barsacchi, R; Cantoni, O; Clementi, E; De Nadai, C; Lièvremont, JP; Meldolesi, J; Moncada, S; Sciorati, C; Sestili, P | 1 |
| Bussygina, OG; Khropov, YV; Makhova, NN; Ovchinnikov, IV; Pyatakova, NV; Severina, IS | 1 |
| Jonas, M; Mundey, MK; Scholefield, JH; Wilson, VG; Worthley, T | 1 |
| Kato, T; Nakamura, K; Yamamoto, H; Yamamoto, T; Yuyama, K | 1 |
| Bény, JL; Flammer, J; Fleischhauer, JC; Haefliger, IO | 1 |
| Patel, KN; Scholz, PM; Weiss, HR | 1 |
| Duarte, ID; Ferreira, SH | 1 |
| Hata, F; Nakagawa, M; Niioka, S; Nishio, H; Okishio, Y; Takeuchi, T; Yamaji, M | 1 |
| Huang, MW; Scholz, PM; Weiss, HR; Yan, L | 1 |
| Falck, JR; Harder, DR; Okamoto, H; Roman, RJ; Sun, CW | 1 |
| Barrachina, MD; Esplugues, JV; García-Zaragozá, E; Moreno, L | 1 |
| Becherini, L; MacIntyre, I; Mancini, L; Martineti, V; Moradi-Bidhendi, N | 1 |
| Johns, RA; Li, D; Shirakami, G; Zhan, X | 1 |
| Marcoli, M; Maura, G; Pepicelli, O; Raiteri, M; Rosu, C; Viola, C | 1 |
| Clark, E; Conklin, JL; Murray, JA; Shahin, W | 1 |
| Baumgarten, G; Dibbs, Z; Kalra, D; Mann, DL; Seta, Y; Sivasubramanian, N | 1 |
| Ekelund, UE; Georgakopoulos, D; Hare, JM; Harrison, RW; Isoda, T; Kass, DA; Ozaki, M; Paolocci, N; Vandegaer, K | 1 |
| Golding, S; Herring, N; Paterson, DJ | 1 |
| Lovren, F; Triggle, C | 1 |
| Bicker, G; Seidel, C | 1 |
| Homer, KL; Wanstall, JC | 2 |
| Berggren, PO; Cooney, RV; Sjöholm, A | 1 |
| Karlsson, AM; Loitto, VM; Nilsson, HM; Sundqvist, T; Svensson, SP | 1 |
| Ellis, DZ; Nathanson, JA; Sweadner, KJ | 1 |
| Genade, S; Lochner, A; Marais, E; Moolman, JA | 1 |
| Magid, KS; Megson, IL; Shaw, CA; Sogo, N; Webb, DJ | 1 |
| Aldinucci, C; Benocci, A; Frosini, M; Meini, A; Palmi, M; Pessina, G; Sgaragli, G; Youmbi, GT | 1 |
| Al-Hassani, M; Gupta, MP; Hart, CM; Natarajan, V; Ober, MD; Patterson, C | 1 |
| Gerstenblith, G; Hare, JM; Lakatta, EG; Ricker, KM; Rosas, GO; Vandegaer, K; Zieman, SJ | 1 |
| Hanna, ST; Peterson-Wakeman, R; Wang, R; Wang, Z; Wu, L | 1 |
| Axer, H; Steinbusch, HW; Teunissen, CE | 1 |
| Eguchi, D; Katusic, ZS | 1 |
| Gustafsson, LE; Hallén, K; Olgart, C; Wiklund, NP | 1 |
| Cernuda-Morollón, E; Díaz-Cazorla, M; Lamas, S; Pérez-Sala, D; Rodríguez-Pascual, F | 1 |
| Mayeux, PR; Zhang, C | 1 |
| Diamond, J; Hennan, JK | 1 |
| Aonuma, H; Newland, PL | 1 |
| Prado, WA; Sousa, AM | 1 |
| Alloatti, G; Bedendi, I; Biasin, C; Gallo, MP; Levi, RC; Malan, D | 1 |
| Ferreyra, GA; Golombek, DA | 1 |
| Huang, Q; Huang, X; Jin, C; Liu, J; Yang, GY; Zhao, KS | 1 |
| Ahn, D; Chung, S; Kwon, S; Nam, T; Yeon, D | 1 |
| Ingram, JN; Renfree, MB; Shaw, G | 1 |
| Ho-Pao, CL; Leamey, CA; Sur, M | 1 |
| Aldieri, E; Bosia, A; Costamagna, C; Ghigo, D; Lindblom, B; Massobrio, M; Moffa, F; Ochetti, S; Revelli, A | 1 |
| Anfossi, G; Cavalot, F; Massucco, P; Mattiello, L; Russo, I; Trovati, M | 1 |
| Ke, X; Nabika, T; Nakashima, Y; Nariai, Y; Tanigawa, Y; Terashima, M | 1 |
| Brodowsky, R; Dirnagl, U; Dreier, JP; Klee, R; Lindauer, U; Lobsien, E; Schuh-Hofer, S; Vogt, J | 1 |
| Gonzalez, A; Sarna, SK | 1 |
| Edvinsson, L; Jansen-Olesen, I; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| de Groat, WC; Seki, S; Yoshimura, N | 1 |
| Bonavita, F; Facchini, A; Flamigni, F; Stanic, I; Stefanelli, C; Tantini, B | 1 |
| Basini, G; Bussolati, S; Grasselli, F; Ponderato, N; Tamanini, C | 1 |
| Castel, H; Vaudry, H | 1 |
| Buxton, IL; Kaiser, RA; Malmquist, NA; Tichenor, S | 1 |
| Herring, N; Paterson, DJ | 1 |
| Argibay, J; Hoebeke, J; Nascimento, JH; Peineau, N; Sallé, L | 1 |
| Bon, CL; Garthwaite, J | 1 |
| Brown, C; Hassid, A; Lin, Y | 1 |
| Chen, IJ; Chiang, LC; Lin, CY; Lin, RJ; Shen, KP; Wu, BN | 1 |
| Carey, RM; Jin, XH; Siragy, HM | 1 |
| Fujita, A; Hata, F; Morimoto, H; Sugimoto, K; Takeuch, T | 1 |
| Paterson, WG; Zhang, Y | 1 |
| Ahern, GP; Jackson, MB; Klyachko, VA | 1 |
| Chai, CY; Su, CK; Wang, Y; Wu, WC | 1 |
| Antunes, E; Conran, N; de Nucci, G; Ferreira, HH; Lorand-Metze, I; Thomazzi, SM | 1 |
| Jacobson, KL; Ott, SM; Singh, JC; Watson, EL | 1 |
| Degan, M; Gaino, S; Lechi, A; Meneguzzi, A; Minuz, P; Santonastaso, CL; Soldato, PD; Zuliani, V | 1 |
| Buvinic, S; Huidobro-Toro, JP | 1 |
| Adler-Graschinsky, E; Boric, MP; Figueroa, XF; Huidobro-Toro, JP; Mendizábal, VE; Poblete, MI | 1 |
| Baltrons, MA; García, A; Pedraza, CE | 1 |
| Naik, JS; Walker, BR | 1 |
| Bers, DM; Katoh, H; Ziolo, MT | 1 |
| Gao, Y; Moessinger, A; Raj, JU; Sander, FC; Souici, AC; Tolsa, JF | 1 |
| Bishop, CD; Brandhorst, BP | 1 |
| Darley-Usmar, V; Murphy-Ullrich, JE; Poczatek, MH; Shiva, S; Wang, S | 1 |
| Barreiro, EJ; Noël, F; Silva, CL | 1 |
| Bryan, RM; Schildmeyer, LA | 1 |
| Alexander, BT; Davis, JR; Giardina, JB; Granger, JP; Green, GM; Khalil, RA | 1 |
| Gutiérrez, AM; Liu, R; Persson, AEG; Ring, A | 1 |
| Galle, J; Ibarra-Alvarado, C; Mameghani, A; Melichar, VO; Schmidt, HH | 1 |
| Bolton, TB; Gordienko, DV; Pucovský, V | 1 |
| Abreu, P; Gonzalez, MC; Sanchez, JJ | 1 |
| Bolli, R; Kodani, E; Shinmura, K; Takano, H; Tang, XL; Xuan, YT | 1 |
| Heiberg, IL; Rosenberg, R; Wegener, G | 1 |
| Liu, R; Persson, AE | 1 |
| Beranova, P; Boucher, JL; Callizot, N; Chalupsky, K; Entlicher, G; Mansuy, D; Muller, B; Schott, C; Stoclet, JC; Vetrovsky, P | 1 |
| Graier, WF; Groschner, K; Malli, R; Schmidt, K; Thyagarajan, B | 1 |
| Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Rosas, R; Torres-López, JE; Vidal-Cantú, GC | 1 |
| Bloodsworth, A; Chumley, PH; Eiserich, JP; Freeman, BA; Krishna, NR; Lim, DG; O'Donnell, VB; Schopfer, F; Sweeney, S; White, CR | 1 |
| Campbell, C; Komai-Koma, M; Liew, FY; Niedbala, W; Thomson, D; Wei, XQ | 1 |
| Brioni, JD; Hsieh, GC; Moreland, RB; O'Neill, AB; Sullivan, JP | 1 |
| Fujimoto, S; Mori, M; Tsushima, H | 1 |
| Elphick, MR; Melarange, R | 1 |
| Kankuri, E; Kotikoski, H; Vapaatalo, H | 1 |
| Bracale, R; Carruba, MO; Clementi, E; Cozzi, V; Francolini, M; Moncada, S; Nisoli, E; Paolucci, C; Sciorati, C; Tonello, C; Valerio, A | 1 |
| Chen, YH; LaPolt, PS; Ngo, A; Tafoya, M | 1 |
| Ishikawa, T; Kaneko, Y; Nakayama, K; Sugino, F | 1 |
| Gupte, SA; Iesaki, T; Mingone, CJ; Wolin, MS | 1 |
| Deng, A; Thomson, SC | 1 |
| Ferreira, SH; Parada, CA; Vivancos, GG | 1 |
| Connelly, L; Hobbs, AJ; Jacobs, AT; Moncada, S; Palacios-Callender, M | 1 |
| Beckman, DL; Liu, L; Mehta, P; Sun, P; Wang, J | 1 |
| Hobbs, AJ; MacAllister, RJ; Madhani, M; Scotland, RS | 1 |
| Arai, RJ; Debbas, V; Monteiro, HP; Morais, MS; Oliveira, CJ; Schindler, F; Stern, A; Ventura, AM | 1 |
| Abe, J; Aizawa, T; Berk, BC; Miano, JM; Wei, H; Yan, C | 1 |
| Forgèt, MA; Sisson, JH; Wyatt, TA | 1 |
| Bátkai, S; Begg, M; Kunos, G; Lovinger, DM; Mo, FM; Offertaler, L; Pacher, P; Razdan, RK | 1 |
| Befus, AD; Cass, C; Graham, K; Marcet-Palacios, M; Mayers, I; Radomski, MW | 1 |
| Morato, GS; Wazlawik, E | 1 |
| Chen, CT; Chou, CJ; Lu, MK; Tsai, TH; Tseng, HW; Wang, GJ | 1 |
| Chen, CJ; Chen, JS; Chen, LW; Hsu, CM; Hwang, YC; Wang, JS | 1 |
| Goldstein, I; Jeong, SJ; Kim, NN; Kim, SW; Munarriz, R; Traish, AM | 1 |
| Chan, SL; Fiscus, RR | 1 |
| Cho, KW; Cui, Y; Kim, HJ; Koh, GY; Oh, HK; Park, JK | 1 |
| Jun, CH; Lee, TS; Sohn, UD | 1 |
| Déciga-Campos, M; López-Muñoz, FJ | 1 |
| De Godoy, M; Li, F; Rattan, S | 1 |
| Antunes, E; Baracat, JS; De Nucci, G; de Oliveira, JF; Fregonesi, A; Okuyama, CE; Priviero, FB; Rodrigues Netto, N; Teixeira, CE | 1 |
| Ceacareanu, AC; Ceacareanu, B; Chapman, KE; Dixit, M; Hassid, A; Lin, Y; Rao, GN; Waters, CM; Zhuang, D | 1 |
| Brørs, O; Jensen, J; Melien, Ø; Sharikabad, MN; Østbye, KM | 1 |
| Cho, KW; Cui, X; Jin, JY; Kim, SH; Kim, SM; Kim, SZ; Lee, HS; Wen, JF | 1 |
| Cunha, FQ; Ferreira, SH; Sachs, D | 1 |
| Beck, KF; Keller, T; McDonald, MC; Pfeilschifter, J; Plesková, M; Thiemermann, C | 1 |
| Carey, RM; Felder, RA; Gildea, JJ; Jin, XH; McGrath, HE; Siragy, HM | 1 |
| Levy, D; Strassman, AM | 1 |
| Chan, MH; Chen, HH; Chien, TH; Lee, PY | 1 |
| Khalil, RA; Orshal, JM | 1 |
| Brading, AF; Deka, DK | 1 |
| Chung, E; Li, S; Quock, RM | 1 |
| Barkoudah, E; Jaggar, JH; Leffler, CW | 1 |
| Albrecht, J; Hilgier, W; Oja, SS; Saransaari, P | 1 |
| Araki, M; Fujimoto, S; Nagayama, T; Newland, PL; Schuppe, H | 1 |
| Aonuma, H; Niwa, K | 1 |
| Correia, NC; Guarino, MP; Lautt, WW; Macedo, MP | 1 |
| Ambrósio, AF; Araújo, IM; Carvalho, CM; Verdasca, MJ | 1 |
| Dorovini-Zis, K; Vincent, SR; Wong, D | 1 |
| Bendhack, LM; Sendão Oliveira, AP | 1 |
| Chen, KH; Chen, SJ; Wu, CC | 1 |
| Bluyssen, H; Braam, B; de Roos, R; Holstege, F; Joles, JA; Kemmeren, P; Koomans, H | 1 |
| Ekerhovd, E; Norström, A | 1 |
| Bawankule, DU; Chanda, D; Krishna, AV; Mishra, SK; Prakash, VR; Sardar, KK; Sathishkumar, K | 1 |
| Britigan, BE; Giriyappa, RL; Husted, RF; Stokes, JB; Uc, A | 1 |
| Gandhi, CR; Thirunavukkarasu, C; Uemura, T; Wang, LF; Watkins, SC | 1 |
| Ahn, DS; Chung, SS; Lee, HG; Lee, YH; Nam, TS | 1 |
| Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F | 1 |
| Diallo, AS; Lobysheva, I; Muller, B; Sarr, M; Schini-Kerth, VB; Stoclet, JC | 1 |
| Dorovini-Zis, K; Prameya, R; Vincent, SR; Wong, D; Wu, V | 1 |
| Asplund Persson, A; Bengtsson, T; Grenegård, M; Lindström, E; Whiss, PA; Zalavary, S | 1 |
| Angelini, GD; Jeremy, JY; Jones, R; Persad, R; Shukla, N | 1 |
| Beranova, P; Boucher, JL; Chalupsky, K; Kleschyov, AL; Mansuy, D; Muller, B; Munzel, T; Schott, C; Stoclet, JC | 1 |
| Angelini, GD; Jeremy, JY; Muzaffar, S; Shukla, N; Srivastava, A | 1 |
| Elmedal Laursen, B; Mulvany, MJ; Simonsen, U | 1 |
| Bianciotti, LG; di Nunzio, A; Hope, SI; Legaz, G; Morgazo, C; Perfume, G; Vatta, MS | 1 |
| Bose, D; Bose, R; Cheng, ZQ; Duke, K; Jacobs, H; Light, RB; Mink, SN; Roberts, DE | 1 |
| Kamei, J; Saitoh, A; Tamura, N | 1 |
| Cheng, JT; Liao, CH; Teng, CM | 1 |
| Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH | 1 |
| Jin, L; Palmer, T; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z | 1 |
| Grenegård, M; Gunnarsson, P; Lindström, E; Persson, AA | 1 |
| Birk, S; Edvinsson, L; Engel, U; Khurana, TS; Kruuse, C; Olesen, J; Rybalkin, SD | 1 |
| Choi, DH; Kang, DG; Kwon, TO; Lee, HS; Lee, JK; Moon, MK | 1 |
| Cao, S; Chatterjee, S; Farrugia, G; Gadgil, J; Gibbons, SJ; Langer, DA; Perri, RE; Shah, VH | 1 |
| Chan, SL; Chan, SS; Fiscus, RR; Fraser, M; Tsang, BK | 1 |
| Antunes, E; Baracat, JS; Claudino, MA; De Nucci, G; Priviero, FB; Teixeira, CE; Webb, RC | 1 |
| Priviero, FB; Teixeira, CE; Todd, J; Webb, RC | 1 |
| Allanson, M; Domanski, D; Reeve, VE | 1 |
| Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Hull, EM; Sato, SM | 1 |
| Matschke, K; Waldow, T; Weber, E; Witt, W | 1 |
| Maeyama, K; Matsui, H; Matsuura, B; Onji, M; Shibata, N; Yokota, T | 1 |
| Bennett, VJ; Papaconstandinou, NA; Reynolds, IJ; Rintoul, GL | 1 |
| Chattopadhyay, A; Chaudhuri, U; Dasgupta, AK; Lahiri, P | 1 |
| Chmelíková, E; Jílek, F; Lánská, V; Petr, J; Pribánová, M; Rajmon, R; Tománek, M | 1 |
| Bryan, NS; Calvert, JW; Duranski, MR; Elrod, JW; Feelisch, M; Lefer, DJ | 1 |
| Cao, LH; Choi, DH; Kang, DG; Kim, JS; Kim, SJ; Lee, H; Lee, HS; Lee, JK | 1 |
| Brito, GA; Cunha, FQ; Ferreira, SH; Lotufo, CM; Ribeiro, RA; Sachs, D; Vale, ML | 1 |
| Furukawa, K; Motomura, S; Seya, K | 1 |
| Abu-Soud, HM; Diamond, MP; Gonik, B; Goud, AP; Goud, PT | 1 |
| Antonov, AS; Antonova, GN; Catravas, JD; Dimitropoulou, C; Snead, CM; Venema, RC | 1 |
| Chen, JJ; Lee, HH; Shih, CD | 1 |
| Arrigoni, E; Rosenberg, PA | 1 |
| Erguven, E; Giannini, P; Lutz, T; Riediger, T | 1 |
| Chang, HS; Hwang, YH; Ju, HJ; Kang, KH; Kim, EC; Lee, SK; Min, KS; Pi, SH | 1 |
| Kim, M; Perrino, BA | 1 |
| Glynos, C; Kotanidou, A; Magkou, C; Orfanos, SE; Papapetropoulos, A; Roussos, C; Simoes, DC; Zhou, Z | 1 |
| Dar, MS; Smith, AD | 1 |
| Blevins, DE; Drummond, JT; Lutz, MC; Nickels, TJ; Reed, GW; Wilson, DF | 1 |
| Arnolda, LF; Holobotovskyy, VV; Malik, V; McKitrick, DJ; Phillips, JK | 1 |
| Eltze, M; Grebe, T; Hatzelmann, A; Klein, T; Kömhoff, M | 1 |
| Fu, WM; Jeng, KC; Kuo, SC; Lee, FY; Liou, HC; Lu, DY; Tang, CH; Teng, CM | 1 |
| Cavalcante, IF; Ribeiro, RA; Rolim, DE; Souza, MH; Vale, ML | 1 |
| Befus, AD; Duszyk, M; Duta, F; Duta, V; Puttagunta, L | 1 |
| Chen, J; Fan, F; Han, L; Wang, S; Wang, X; Xie, X; Yan, J; Zhou, X | 1 |
| Dawson, TA; Lee, CW; Li, D; Paterson, DJ; Wang, L | 1 |
| Jang, Y; Mueller, RA; Norfleet, EA; Wang, H; Xi, J; Xu, Z | 1 |
| da-Silva, CA; Del Bel, EA; Echeverry, MB; Ferreira, FR; Salgado, ML | 1 |
| Faggio, C; Pidalà, P; Trischitta, F | 1 |
| Brouckaert, P; Buys, E; Nimmegeers, S; Sips, P; Van de Voorde, J | 1 |
| Bagcivan, I; Berkan, O; Doğan, K; Kaya, T; Yildirim, K; Yildirim, S | 1 |
| Bouallegue, A; Daou, GB; Srivastava, AK | 1 |
| Dunkern, TR; Feurstein, D; Hatzelmann, A; Rossi, GA; Sabatini, F | 1 |
| Del Bel, EA; Echeverry, MB; Guimarães, FS; Iyomasa, M; Spolidório, PC | 1 |
| Edwards, TM; Lindley, N | 1 |
| Anrather, J; Iadecola, C; Kawano, T; Kunz, A; Orio, M; Zhou, P | 1 |
| Bellas, E; Bloch, KD; Buys, ES; Evgenov, NV; Evgenov, OV; Gnoth, MJ; Graveline, AR; Hess, DR; Kohane, DS; Langer, R; Liu, R; Stasch, JP; Volpato, GP; Zapol, WM | 1 |
| Fejgin, K; Klamer, D; Pålsson, E; Svensson, L; Wass, C | 1 |
| Cuvelier, C; Demetter, P; Lefebvre, RA; Timmermans, JP; Van Crombruggen, K; Van Nassauw, L | 1 |
| Azuma, H; Imamura, M; Isotani, E; Mizuno, Y; Nagai, A; Ohno, K | 1 |
| Brito, GA; Gadelha, GG; Garcia, JA; Lima, SJ; Medeiros, JV; Ribeiro, RA; Santos, AA; Soares, PM; Souza, MH | 1 |
| Ishikawa, T; Nakayama, K; Sunouchi, T; Suzuki, K | 1 |
| Bose, R; Cheng, ZQ; Jacobs, H; Kasian, K; Light, RB; Mink, SN; Santos Martinez, LE | 1 |
| Brock, SC; Tonussi, CR | 1 |
| Canalli, AA; Conran, N; Costa, FF; Franco-Penteado, CF; Saad, ST | 1 |
| Caldas-Bussiere, MC; Costa, FR; Dias, BL; Escocard, RM; Faes, MR; Viana, KS | 1 |
| Dismuke, WM; Ellis, DZ; Mbadugha, CC | 1 |
| de Vente, J; Diederen, RM; Hendrikse, F; La Heij, EC; Markerink-van Ittersum, M | 1 |
| Brouckaert, P; Buys, E; De Backer, O; Elinck, E; Lefebvre, RA; Sips, P | 1 |
| Brouckaert, P; Buys, E; Dhaese, I; Lefebvre, RA; Sips, P; Vanneste, G | 1 |
| Costa, G; García-Pascual, A; Sancho, M; Triguero, D | 1 |
| Cha, KH; Choi, S; Jeong, HS; Jun, JY; Kim, MY; Kim, YD; Parajuli, SP; Park, CG; Park, JS; Park, YB; Yeum, CH | 1 |
| Katiyar, SK; Punathil, T | 1 |
| Katiyar, SK; Punathil, T; Tollefsbol, TO | 1 |
| Benjamin, PR; Korneev, SA; O'Shea, M; Picot, J; Ribeiro, M; Schofield, M; Straub, VA | 1 |
| Ishikawa, T; Nakayama, K; Noguchi, A; Takada, M | 1 |
| Bird, PS; Seymour, GJ; Sosroseno, W | 1 |
| Assreuy, J; Barja-Fidalgo, C; Fernandes, D; Heckert, BT; Lobo, AR; Nardi, GM; Pacheco, LK; Sordi, R; Villela, CG | 1 |
| Chokshi, BM; Dismuke, WM; Ellis, DZ | 1 |
| Kauer, JA; Niehaus, JL; Nugent, FS | 1 |
| Dismuke, WM; Ellis, DZ; Sharif, NA | 1 |
| Lograno, MD; Romano, MR | 1 |
| Favaloro, JL; Kemp-Harper, BK | 1 |
| Augusto, O; Gomes, SL; Linares, E; Vieira, AL | 1 |
| Lincoln, TM; Pearce, WJ; White, CR; Williams, JM | 1 |
| Abman, SH; Chester, M; Gien, J; Grover, TR; Seedorf, G; Tourneux, P | 1 |
| Gladwin, M; Isenberg, JS; Shiva, S | 1 |
| Clemente-Napimoga, JT; Ferreira, VH; Napimoga, MH; Parada, CA; Pellegrini-da-Silva, A; Tambeli, CH | 1 |
| Kerschbaum, HH; Nimmervoll, B; Sacha, B; Svoboda, N | 1 |
| Hajjhussein, H; Hamza, A; Huang, Y; Li, H; Masood, A; O'Donnell, JM; Wang, W; Xiao, L; Zhan, CG | 1 |
| Carey, RM; Gildea, JJ; Howell, NL; Kemp, BA; Lieb, DC | 1 |
| Irwin, C; Naseem, KM; Roberts, W | 1 |
| Arendshorst, WJ; Fellner, SK | 1 |
| Makris, AC; Makropoulou, M; Papapetropoulos, A; Papapetropoulos, N; Pyriochou, A; Roussos, C; Sotzios, Y; Vassilakopoulos, T; Zacharatos, P; Zhou, Z | 1 |
| Fiscus, RR; Johlfs, MG | 1 |
| Baxter, GF; Gowers, I; Rautureau, Y; Wheeler-Jones, CP | 1 |
| Batalhao, ME; Branco, LG; Carnio, EC; Ravanelli, MI; Soriano, RN | 1 |
| Cheng, J; Fu, Y; Hamid, MI; Jiang, D; Li, B; Li, G; Xie, J; Yi, X | 1 |
| Cho, KW; Cui, HZ; Kang, DG; Kim, HY; Lee, HS; Li, X | 1 |
| Cosgrave, AS; McKay, JS; Thippeswamy, T | 1 |
| Goy, D; Gummersbach, C; Hemmrich, K; Kröncke, KD; Pallua, N; Paul, NE; Suschek, CV | 1 |
| Dong, H; Hao, F; Miao, C; Sun, L; Zhang, H; Zhao, S | 1 |
| Dou, D; Gao, Y; He, Q; Ma, H; Raj, JU; Wu, Y; Ying, L; Zheng, X | 1 |
| de Montaigu, A; Fernández, E; Galván, A; Sanz-Luque, E | 1 |
| Hedenstierna, G; Hjoberg, J; Jonasson, S | 1 |
| Aguila, FA; Basso, PJ; Oliveira-Pelegrin, GR; Rocha, MJ | 1 |
| Barnett, SD; Buxton, IL; Milton, D; Tichenor, SD | 1 |
| Antunes, E; De Nucci, G; Mónica, FZ; Morganti, RP; Toque, HA | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Sarac, B; Sencan, M; Turan, M | 1 |
| Claes, JM; Holmgren, S; Krönström, J; Mallefet, J | 1 |
| Liu, S; Luo, J; Wang, Y; Yang, X; Yang, Z | 1 |
| Bombarda, G; da Silva, CA; Fazan, R; Sabino, JP; Salgado, HC; Salgado, MC | 1 |
| Komori, S; Matsuyama, H; Takewaki, T; Unno, T | 1 |
| Balfagón, G; Blanco-Rivero, J; Cogolludo, A; del Campo, L; Márquez-Rodas, I; Nava, MP; Pérez-Vizcaíno, F; Sastre, E | 1 |
| Fujita, M; Ito, S; Iwasaka, T; Katano, T; Okazaki, T; Otani, H; Shimazu, T; Yoshioka, K | 1 |
| Chen, SD; Hwang, CS; Tang, CM; Yang, DI | 1 |
| Bloch, KD; Busch, CJ; Graveline, AR; Jiramongkolchai, K; Liu, H; Sanchez, LS | 1 |
| Chung, E; Ohgami, Y; Quock, LP; Quock, RM; Zhang, Y | 1 |
| Juni, RP; Moens, AL | 1 |
| Fiscus, RR; Wong, JC | 1 |
| Hobbs, AJ; Khambata, RS; Panayiotou, CM | 1 |
| Antunes, E; Arruda, AM; Barillas, S; Capel, RO; Cogo, JC; De Nucci, G; de Oliveira, MA; Mónica, FZ; Muscará, MN; Nahoum, C; Pissinatti, A; Pissinatti, L; Porto, M; Schenka, AA; Teixeira, SA | 1 |
| Castro, RR; Cunha, FQ; Girão, VC; Leite, AC; Leite, AK; Rocha, FA; Silva, FS | 1 |
| Arner, A; de Sá, VP; Ekblad, E; Harnek, J; Stenram, U; Zoucas, E | 1 |
| Buck, J; Hess, KC; Levin, LR; Ramos-Espiritu, LS | 1 |
| Balen, Gde O; Budni, J; Fernandes, SC; Freitas, AE; Moretti, M; Rodrigues, AL | 1 |
| Abman, SH; Chester, M; Gien, J; Grover, T; Seedorf, G; Stasch, JP; Tourneux, P; Tseng, N; Wright, J | 1 |
| Gajdus, M; Glaza, I; Gurtowska, N; Rzepka, A; Szadujkis-Szadurski, L; Szadujkis-Szadurski, R | 1 |
| Bak, YO; Choi, BR; Jeon, JH; Kim, HK; Lee, SW; Park, JK; So, I; Zhao, C | 1 |
| Blume, SR; Caballero, A; Cass, DK; Dec, A; Park, DJ; Park, MJ; Sammut, S; Simak, N; Sunu, E; Tseng, KY; West, AR | 1 |
| Chen, XF; Huang, YJ; Lin, DY; Xu, XL; Zhang, W | 1 |
| Aricioglu, F; Utkan, T; Yazir, Y | 1 |
| Barbosa, AL; Moraes, MO; Oliveira, GJ; Pinheiro, CA; Ribeiro, RA; Souza, MH; Torres, JN; Vale, ML | 1 |
| Carvalho, FB; Ferreira, J; Girardi, BA; Marisco, PC; Mello, CF; Oliveira, MS; Rubin, MA; Tonello, R | 1 |
| Cosyns, SM; Lefebvre, RA | 1 |
| Blouquit-Laye, S; Braun, C; Chinet, T; Dannhoffer, L; Dinh-Xuan, AT; Sage, E | 1 |
| He, LS; Lee, OO; Matsumura, K; Qian, PY; Xu, Y; Zhang, G; Zhang, Y | 1 |
| Burgoyne, JR; Eaton, P; Prysyazhna, O; Rudyk, O | 1 |
| Huang, J; Matavelli, LC; Siragy, HM | 1 |
| Kang, YH; Morgan, KG; Shin, HM; Yang, IJ | 1 |
| Chen, Y; Chitapanarux, T; Melton, AC; Soon, RK; Wu, J; Yee, HF | 1 |
| Andrade E Silva, ML; Bastos, JK; Carvalho, MT; Celotto, AC; Cunha, WR; Evora, PR; Rezende, KC | 1 |
| Cuong, NM; Dung, PT; Durante, M; Fusi, F; Nam, NH; Sgaragli, G | 1 |
| Gashev, AA; Gasheva, OY; Zawieja, DC | 1 |
| Bao, CR; Ding, FB; Huang, JB; Liu, H; Ma, N; Mei, J; Yan, YM; Zhang, JW | 1 |
| Dismuke, WM; Liang, J; Overby, DR; Stamer, WD | 1 |
| Bae, H; Bang, H; Kim, JH; Kim, K; Kim, T; Ko, JH; Lee, HJ; Lim, I | 1 |
| Chiu, HC; Lee, TY; Lien, LM; Lin, KH; Lu, WJ; Sheu, JR; Thomas, PA; Yen, TL | 1 |
| Almeida, R; Duarte, ID; Fontes, MA; Galdino, GS; Menezes, G; Perez, AC; Silva, G; Xavier, CH | 1 |
| Kosakai, K; Tsujiuchi, Y; Yoshino, M | 1 |
| Fernández-Fernández, D; Kroker, KS; Rosenbrock, H | 1 |
| Busch, M; Busch, R; Dörr, M; Eckerle, LG; Felix, SB; Gross, S; Hertrich, I; Rauch, BH; Reinke, Y; Riad, A; Stasch, JP | 1 |
| Bathgate, RA; Samuel, CS; Sarwar, M; Stewart, DR; Summers, RJ | 1 |
| Lueptow, LM; O'Donnell, JM; Zhan, CG | 1 |
| Blood, AB; Liu, T; Longo, LD; Power, GG; Schroeder, HJ; Terry, MH; Wilson, SM; Zhang, M | 1 |
| Alves, FHF; Correa, FMA; Crestani, CC; Ferreira-Junior, NC; Lagatta, DC; Resstel, LBM | 1 |
| Belmonte, G; Frosini, M; Pessina, F; Sticozzi, C | 1 |
| Clark, BJ; El-Mallakh, RS; Gao, Y; Hamlyn, JM; Tegin, G | 1 |
418 other study(ies) available for quinoxalines and cyclic gmp
| Article | Year |
|---|---|
Excitatory amino acid receptors coupled to the nitric oxide/cyclic GMP pathway in rat cerebellum during development.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Amino Acids; Animals; Cerebellum; Cyclic GMP; Female; Glutamates; Glutamic Acid; Male; Nitric Oxide; Quinoxalines; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1991 |
GABA release triggered by the activation of neuron-like non-NMDA receptors in cultured type 2 astrocytes is carrier-mediated.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Carrier Proteins; Cells, Cultured; Cerebellum; Chlorides; Cyclic GMP; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Kynurenic Acid; Lithium; Lithium Chloride; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Nipecotic Acids; Nitroprusside; Organic Anion Transporters; Proline; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Neurotransmitter; Secretory Rate; Sodium; Stimulation, Chemical | 1991 |
Role of cGMP in the mechanism of anxiolytic activity of U-78875.
Topics: Animals; Anti-Anxiety Agents; Binding, Competitive; Brain Chemistry; Carbolines; Cerebellum; Convulsants; Cyclic GMP; Diazepam; Dose-Response Relationship, Drug; Electroshock; Flunitrazepam; Male; Mice; Muscimol; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Strains; Stress, Psychological | 1991 |
Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acid Oxidoreductases; Animals; Arginine; Cerebellum; Cyclic GMP; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hemoglobins; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Potassium; Purkinje Cells; Pyridines; Quinoxalines; Rats; Rats, Inbred Strains; Synapses | 1991 |
Modulation of non-N-methyl-D-aspartate receptors in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cells, Cultured; Cerebellum; Cyclic GMP; Granulocytes; Ibotenic Acid; Kainic Acid; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Brimonidine Tartrate; Cyclic GMP; Endothelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Rats; Rats, Inbred Strains | 1986 |
Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion.
Topics: Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Swine; Terpenes; Thapsigargin | 1995 |
Characterization of a novel potent and specific inhibitor of type V phosphodiesterase.
Topics: Allopurinol; Animals; Atrial Natriuretic Factor; Cattle; Cyclic AMP; Cyclic GMP; Imidazoles; Isoenzymes; Muscle, Smooth, Vascular; Nitroprusside; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Purinones; Quinoxalines; Rats; Sensitivity and Specificity; Stimulation, Chemical | 1995 |
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Cattle; Cells, Cultured; Cerebellum; Cyclic GMP; Guanylate Cyclase; Hippocampus; In Vitro Techniques; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 1995 |
Glutamate receptor-induced cyclic GMP formation in primary cultures of mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Arginine; Carbachol; Cells, Cultured; Cyclic GMP; Fetus; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Kinetics; Mesencephalon; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Phorbol 12,13-Dibutyrate; Quinoxalines; Receptors, Glutamate | 1993 |
Effects of moxonidine, an imidazoline antihypertensive agent, on second messenger systems in rat brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Brain Chemistry; Brain Stem; Brimonidine Tartrate; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic GMP; Imidazoles; In Vitro Techniques; Norepinephrine; Phosphatidylinositols; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Second Messenger Systems; Yohimbine | 1994 |
Non-classical glutamate receptors, blocked by both NMDA and non-NMDA antagonists, stimulate nitric oxide production in neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arginine; Cells, Cultured; Corpus Striatum; Cyclic GMP; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Mice; N-Methylaspartate; Neurons; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Pregnancy; Quinoxalines; Quisqualic Acid; Receptors, Glutamate | 1993 |
Cytotoxic actions and effects on intracellular Ca2+ and cGMP concentrations of sulphur-containing excitatory amino acids in cultured cerebral cortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids, Sulfur; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Female; Fluorescence; Mice; Neurons; Pregnancy; Quinoxalines; Radioimmunoassay | 1993 |
Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures.
Topics: Animals; Arginine; Calcium; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Dantrolene; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamates; Glutamic Acid; Hemoglobins; HIV Envelope Protein gp120; HIV-1; Inositol Phosphates; Models, Neurological; Neurons; Neurotoxins; Nifedipine; Nitric Oxide; Nitroarginine; Quinoxalines; Rats | 1993 |
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Lip; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Solubility | 1995 |
Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery.
Topics: Animals; Cattle; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Pulmonary Artery; Quinoxalines; S-Nitrosoglutathione; Swine; Vasodilation | 1996 |
cGMP mediates the vascular and platelet actions of nitric oxide: confirmation using an inhibitor of the soluble guanylyl cyclase.
Topics: Animals; Blood Platelets; Cyclic GMP; Cytosol; Enzyme Inhibitors; Epoprostenol; Guanylate Cyclase; Humans; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitroso Compounds; Oxadiazoles; Oxyhemoglobins; Platelet Aggregation; Quinoxalines; Rats; Vasodilation | 1996 |
Inhibition of nitrergic relaxations by a selective inhibitor of the soluble guanylate cyclase.
Topics: Animals; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Quinoxalines; Rabbits; Solubility; Synaptic Transmission | 1996 |
Kainate produces concentration-dependent elevation of glutamate release but not cGMP levels in cultured neuron.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Kainic Acid; N-Methylaspartate; Neurons; Neurotoxins; Piperazines; Quinoxalines | 1996 |
Desensitization of AMPA receptors and AMPA-NMDA receptor interaction: an in vivo cyclic GMP microdialysis study in rat cerebellum.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cerebellum; Cyclic GMP; Dizocilpine Maleate; Male; Microdialysis; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1996 |
The nitric oxide-cyclic GMP pathway and synaptic plasticity in the rat superior cervical ganglion.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia, Sympathetic; Glutathione; Guanylate Cyclase; Male; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Synaptic Transmission | 1996 |
In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebellum; Cyclic GMP; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Guanylate Cyclase; Hippocampus; Male; Microdialysis; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; S-Nitroso-N-Acetylpenicillamine | 1996 |
Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease.
Topics: 1-Methyl-3-isobutylxanthine; Apolipoproteins E; Arginine; Blood Platelets; Cholesterol; Cyclic AMP; Cyclic GMP; Dimyristoylphosphatidylcholine; Enzyme Inhibitors; Guanylate Cyclase; Humans; Lipoproteins, HDL; Membrane Lipids; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines | 1997 |
Evidence for the involvement of cGMP and protein kinase G in nitric oxide-induced apoptosis in the pancreatic B-cell line, HIT-T15.
Topics: Alkaloids; Animals; Apoptosis; Carbazoles; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione; Indoles; Islets of Langerhans; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione | 1997 |
Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation.
Topics: Animals; Aorta; COS Cells; Cyclic GMP; Guanosine Triphosphate; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Nitroso Compounds; Oxadiazoles; Oxidation-Reduction; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Xanthine; Xanthine Oxidase; Xanthines | 1997 |
The effect of the vasodilator nicotinamide on cyclic nucleotide pathways in vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arteries; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Imines; In Vitro Techniques; Muscle, Smooth, Vascular; Niacinamide; Oxadiazoles; Phenylephrine; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Rats, Wistar; Second Messenger Systems; Vasodilation; Vasodilator Agents | 1997 |
Stimulation of mucin exocytosis from human epithelial cells by nitric oxide: evidence for a cGMP-dependent and a cGMP-independent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Cyclic GMP; Cysteine; Enzyme Inhibitors; Epithelium; Exocytosis; Guanylate Cyclase; Humans; Hydrazines; Mucins; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Reactive Oxygen Species; Superoxide Dismutase | 1997 |
Nitric-oxide-guanylyl-cyclase-dependent and -independent components of multiple forms of long-term synaptic depression.
Topics: Animals; Cyclic GMP; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Hippocampus; Long-Term Potentiation; Male; Neuronal Plasticity; Niacinamide; Nitric Oxide; Organ Culture Techniques; Oxadiazoles; Penicillamine; Platelet Aggregation Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Synapses; Thionucleotides | 1997 |
Nitric oxide decreases stability of mRNAs encoding soluble guanylate cyclase subunits in rat pulmonary artery smooth muscle cells.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cycloheximide; Dactinomycin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glutathione; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Nitrosoglutathione; Time Factors | 1997 |
Nitric oxide inhibits the dopamine-induced K+ current via guanylate cyclase in Aplysia neurons.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aplysia; Cyclic GMP; Dopamine; Enzyme Inhibitors; Ganglia, Invertebrate; Guanylate Cyclase; Hemoglobins; Hydroxylamine; In Vitro Techniques; Kinetics; Membrane Potentials; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Quinoxalines | 1997 |
A potential role of cyclic GMP in the regulation of lordosis behavior of female rats.
Topics: Animals; Cerebellum; Cerebral Ventricles; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hypothalamus; Injections, Intraventricular; Nitric Oxide; Organ Culture Techniques; Oxadiazoles; Posture; Quinoxalines; Rats; Rats, Sprague-Dawley; Sexual Behavior, Animal | 1997 |
Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide.
Topics: Animals; Aorta; Carbon Monoxide; Cell Nucleus; Cells, Cultured; Cyclic GMP; Dactinomycin; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Kinetics; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oligonucleotide Probes; Oxadiazoles; Quinoxalines; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Spermine; Transcription, Genetic | 1997 |
Effects of a novel guanylate cyclase inhibitor on nitric oxide-dependent inhibitory neurotransmission in canine proximal colon.
Topics: Animals; Colon; Cyclic GMP; Dogs; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines | 1997 |
The glutamate receptor/NO/cyclic GMP pathway in the hippocampus of freely moving rats: modulation by cyclothiazide, interaction with GABA and the behavioural consequences.
Topics: Animals; Behavior, Animal; Benzothiadiazines; Cyclic GMP; Diuretics; Drug Interactions; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Hippocampus; Male; Nitric Oxide; Nitric Oxide Synthase; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Chloride Symporter Inhibitors | 1997 |
In vivo microdialysis study of GABA(A) and GABA(B) receptors modulating the glutamate receptor/NO/cyclic GMP pathway in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Cyclic GMP; Epilepsy; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Microdialysis; Nitric Oxide; Quinoxalines; Rats; Receptors, AMPA; Receptors, GABA-A; Receptors, GABA-B; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1997 |
Cyclic guanosine 3',5'-monophosphate-mediated neuroprotection by nitric oxide in dissociated cultures of rat dorsal root ganglion neurones.
Topics: Animals; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Spinal; Guanylate Cyclase; Male; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 1997 |
Effect of selective inhibition of soluble guanylyl cyclase on the K(Ca) channel activity in coronary artery smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Animals; Cattle; Coronary Vessels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Iloprost; In Vitro Techniques; Kinetics; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitroso Compounds; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channels; Quinoxalines; Scorpion Venoms; Vasodilation | 1998 |
Nitric oxide and cyclic nucleotides participate in the relaxation of diclofenac on rat uterine smooth muscle.
Topics: Adenylyl Cyclases; Animals; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Proteins; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Nucleotides, Cyclic; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Sensitivity and Specificity; Sulfonamides; Uterine Contraction; Uterus; Vanadates; Vasodilator Agents; Virulence Factors, Bordetella | 1998 |
Activation of cerebellar climbing fibers increases cerebellar blood flow: role of glutamate receptors, nitric oxide, and cGMP.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Carbon Dioxide; Cerebellum; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Harmaline; Male; Nerve Fibers; Nitric Oxide; Nitroarginine; Oxygen; Partial Pressure; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; S-Nitroso-N-Acetylpenicillamine; Tetrodotoxin; Ultrasonography, Doppler, Transcranial | 1998 |
Localization of heme oxygenase-2 immunoreactivity to parasympathetic ganglia of human and guinea-pig airways.
Topics: Animals; Atropine; Carbon Monoxide; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Parasympathetic; Ganglionic Blockers; Guanylate Cyclase; Guinea Pigs; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Membrane Proteins; Muscarinic Antagonists; Muscle Contraction; Oxadiazoles; Protoporphyrins; Quinoxalines; Receptors, Cholinergic; Respiratory Physiological Phenomena; Respiratory System; Synaptic Transmission; Trimethaphan; Vagus Nerve | 1998 |
Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation.
Topics: Alkaloids; Animals; Blood Pressure; Carbazoles; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hypertension, Pulmonary; Indoles; Lung; Male; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Protein Kinases; Pulmonary Circulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Thionucleotides; Vascular Resistance; Vasoconstriction | 1998 |
Nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Cyclic IMP; Enzyme Activation; Enzyme Inhibitors; Nitric Oxide; Nitroprusside; Oligopeptides; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Retina; Sulfhydryl Reagents | 1998 |
The effect of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and charybdotoxin (CTX) on relaxations of isolated cerebral arteries to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bradykinin; Cerebral Arteries; Charybdotoxin; Colforsin; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Uridine Triphosphate | 1998 |
Evidence for involvement of the cGMP-protein kinase G signaling system in the induction of long-term depression, but not long-term potentiation, in the dentate gyrus in vitro.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Animals; Benzoates; Carbazoles; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glycine; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Long-Term Potentiation; Neurons; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinases; Purinones; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1998 |
Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cell Survival; Cells, Cultured; Cyclic GMP; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Fetus; Guanylate Cyclase; Motor Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; Oxadiazoles; Quinoxalines; Rats; Solubility | 1998 |
Cardioprotection by activation of NO/cGMP pathway after cardioplegic arrest and 8-hour storage.
Topics: Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Coronary Circulation; Cryopreservation; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Arrest, Induced; Heart Transplantation; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardium; Nitric Oxide; Nitroprusside; Oxadiazoles; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Vasodilator Agents; Ventricular Function, Left | 1998 |
Nitric oxide-mediated cGMP production in the islands of Calleja in the rat.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Olfactory Bulb; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred Lew; Tissue Distribution | 1998 |
Nitric oxide donors inhibit the acetylcholine-induced Cl- current in identified Onchidium neurons.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Chlorides; Cyclic GMP; Diethylamines; Electric Conductivity; Enzyme Inhibitors; Hemoglobins; Mollusca; Neurons; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines | 1998 |
Evidence for a cyclic GMP-independent mechanism in the anti-platelet action of S-nitrosoglutathione.
Topics: Cell Membrane; Cyclic AMP; Cyclic GMP; Glutathione; Humans; Hydrazines; In Vitro Techniques; Nitric Oxide; Nitrogen Oxides; Nitroso Compounds; Oxadiazoles; Phenanthrolines; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; Sulfhydryl Compounds | 1998 |
Soluble guanylate cyclase in Saccharomyces cerevisiae.
Topics: Cyclic GMP; Enzyme Stability; Guanylate Cyclase; Nitroprusside; Oxadiazoles; Precipitin Tests; Quinoxalines; Saccharomyces cerevisiae; Solubility | 1998 |
Galanin stimulates the N-methyl-D-aspartate receptor/nitric oxide/cyclic GMP pathway in vivo in the rat ventral hippocampus.
Topics: Animals; Cyclic GMP; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Galanin; Hippocampus; Locomotion; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peptide Fragments; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrodotoxin | 1998 |
Nitric oxide-induced release of acetylcholine in the nucleus accumbens: role of cyclic GMP, glutamate, and GABA.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; Animals; Chromatography, High Pressure Liquid; Cyclic GMP; Diethylamines; Dopamine Antagonists; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanylate Cyclase; Male; Neurons; Nitric Oxide; Nitrogen Oxides; Nucleus Accumbens; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA; Receptors, Glutamate | 1998 |
Norepinephrine increases cyclic GMP levels in cerebellar cells from neuronal nitric oxide synthase knockout mice.
Topics: Animals; Astrocytes; Cerebellum; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Mice; Mice, Knockout; Nerve Tissue Proteins; Neuronal Plasticity; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Norepinephrine; Oxadiazoles; Prazosin; Quinoxalines; Sympatholytics; Sympathomimetics | 1998 |
Nitrergic relaxation of the horse corpus cavernosum. Role of cGMP.
Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Horses; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NADPH Dehydrogenase; Nerve Fibers; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Penis; Potassium Channels; Quinoxalines; Tetrodotoxin | 1998 |
Evidence for the involvement of nitric oxide in the inhibitory effect of GSPYFVamide on Helix aspersa central neurones.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glutathione; Guanylate Cyclase; Helix, Snails; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nitroso Compounds; Oligopeptides; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitrosoglutathione; Sodium Nitrite | 1998 |
Nitric oxide inhibits aldosterone synthesis by a guanylyl cyclase-independent effect.
Topics: Aldosterone; Animals; Atrial Natriuretic Factor; Bacterial Toxins; Cattle; Cells, Cultured; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Guanylate Cyclase; Humans; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Pregnenolone; Quinoxalines; Zona Glomerulosa | 1998 |
Relaxant effects of L-citrulline in rabbit vascular smooth muscle.
Topics: Animals; Aorta; Cells, Cultured; Citrulline; Cyclic GMP; Dexamethasone; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polysaccharides; Potassium Channels; Purinones; Quinoxalines; Rabbits | 1998 |
Cyclic AMP mediates endothelial protection by nitric oxide.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Alkaloids; Animals; Carbazoles; Cattle; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic N-Oxides; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Imidazoles; Indoles; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Pulmonary Artery; Pyrroles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 1998 |
Evidence for NO. redox form of nitric oxide as nitrergic inhibitory neurotransmitter in gut.
Topics: Aminoquinolines; Animals; Apamin; Chloride Channels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Ileum; In Vitro Techniques; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Agents; Niflumic Acid; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; ortho-Aminobenzoates; Oxadiazoles; Oxidation-Reduction; Potassium Channel Blockers; Quinoxalines | 1998 |
Neuronal death induced by SIN-1 in the presence of superoxide dismutase: protection by cyclic GMP.
Topics: Animals; Cell Death; Cyclic GMP; Drug Synergism; Enzyme Inhibitors; Hydrogen Peroxide; Molsidomine; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase; Vasodilator Agents | 1998 |
Comparison of two soluble guanylyl cyclase inhibitors, methylene blue and ODQ, on sodium nitroprusside-induced relaxation in guinea-pig trachea.
Topics: Animals; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Methylene Blue; Mice; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Solubility; Trachea; Vasodilator Agents | 1998 |
Evidence that additional mechanisms to cyclic GMP mediate the decrease in intracellular calcium and relaxation of rabbit aortic smooth muscle to nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Angiotensin II; Animals; Aorta; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Manganese; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase C; Purinones; Quinoxalines; Rabbits; Thionucleotides; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Heme oxygenase and carbon monoxide: regulatory roles in islet hormone release: a biochemical, immunohistochemical, and confocal microscopic study.
Topics: Animals; Blotting, Western; Carbon Monoxide; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Female; Glucose; Heme Oxygenase (Decyclizing); Hemin; Hormones; Immunohistochemistry; Islets of Langerhans; Mice; Mice, Inbred Strains; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Protoporphyrins; Quinoxalines | 1999 |
Nitric oxide-dependent and independent effects on human platelets treated with peroxynitrite.
Topics: Blood Platelets; Calcium; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Free Radical Scavengers; Guanylate Cyclase; Humans; Immunohistochemistry; Nitrates; Nitric Oxide; Oxadiazoles; Oxidants; Oxyhemoglobins; P-Selectin; Platelet Activation; Quinoxalines | 1998 |
Effects of endogenous and exogenous nitric oxide on endothelin-1 production in cultured vascular endothelial cells.
Topics: Animals; Aorta; Benzoates; Cells, Cultured; Cyclic GMP; Endothelin-1; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitro Compounds; Oxadiazoles; Protein Precursors; Quinoxalines; RNA, Messenger; Swine | 1999 |
Inhibition of platelet aggregation by S-nitroso-cysteine via cGMP-independent mechanisms: evidence of inhibition of thromboxane A2 synthesis in human blood platelets.
Topics: Arachidonic Acid; Aspirin; Blood Platelets; Bridged Bicyclo Compounds, Heterocyclic; Collagen; Cyclic GMP; Cysteine; Fatty Acids, Unsaturated; Glutathione; Guanylate Cyclase; Humans; Hydrazines; Inhibitory Concentration 50; Nitric Oxide; Nitrites; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Thromboxane A2 | 1999 |
Afferent arteriolar vasodilation to the sulfonimide analog of 11, 12-epoxyeicosatrienoic acid involves protein kinase A.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; 8,11,14-Eicosatrienoic Acid; Animals; Arterioles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Histones; In Vitro Techniques; Isoquinolines; Juxtaglomerular Apparatus; Kidney Medulla; Kinetics; Male; Microscopy, Video; Muscle, Smooth, Vascular; Nephrons; Norepinephrine; Oxadiazoles; Protein Kinases; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Circulation; Sulfonamides; Vasodilation | 1999 |
Role of nitric oxide production in carbachol-induced negative chronotropy in cultured rat ventricular myocytes.
Topics: Animals; Animals, Newborn; Atropine; Carbachol; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Heart Ventricles; Methylene Blue; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 1999 |
Both protein kinase G dependent and independent mechanisms are involved in the modulation of glutamate release by nitric oxide in rat hippocampal nerve terminals.
Topics: 4-Aminopyridine; Animals; Calcium; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Nitric Oxide; Nitroprusside; Oxadiazoles; Presynaptic Terminals; Protein Kinases; Quinoxalines; Rats; Sulfhydryl Reagents; Synaptosomes; Thionucleotides | 1999 |
Nitric oxide and C-type atrial natriuretic peptide stimulate primary aortic smooth muscle cell migration via a cGMP-dependent mechanism: relationship to microfilament dissociation and altered cell morphology.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Actin Cytoskeleton; Angiotensin II; Animals; Aorta, Thoracic; Cell Movement; Cells, Cultured; Culture Media; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cytoskeleton; Diffusion Chambers, Culture; Guanylate Cyclase; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Myosin Heavy Chains; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley | 1999 |
Piperazine imidazo[1,5-a]quinoxaline ureas as high-affinity GABAA ligands of dual functionality.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Biological Availability; Cell Line; Cerebellum; Convulsants; Cyclic GMP; Drug Evaluation, Preclinical; GABA Agonists; Imidazoles; In Vitro Techniques; Ligands; Male; Mice; Models, Molecular; Molecular Conformation; Pentylenetetrazole; Piperazines; Quinoxalines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures; Structure-Activity Relationship; Urea | 1999 |
Possible novel mechanism for bitter taste mediated through cGMP.
Topics: Aminoquinolines; Animals; Caffeine; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Glycine Agents; Methylene Blue; Mice; Nitro Compounds; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; Signal Transduction; Strychnine; Sulfhydryl Reagents; Taste; Theophylline | 1999 |
Nitric oxide stimulates cGMP production and mimics synaptic responses in metacerebral neurons of Aplysia.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoquinolines; Animals; Aplysia; Cyclic GMP; Cysteine; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Ganglia, Invertebrate; Guanylate Cyclase; Immunohistochemistry; Neurons; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Quinoxalines; S-Nitrosothiols; Stimulation, Chemical | 1999 |
Regulation of neuronal growth cone filopodia by nitric oxide.
Topics: Animals; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Growth Cones; Guanylate Cyclase; Hydrazines; Molsidomine; Mutagens; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Pseudopodia; Quinoxalines; Snails; Sulfhydryl Reagents | 1999 |
Effects of guanylyl cyclase and protein kinase G inhibitors on vasodilatation in non-tolerant and tolerant bovine coronary arteries.
Topics: Animals; Cattle; Coronary Vessels; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Drug Interactions; Drug Tolerance; Enzyme Inhibitors; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitroglycerin; Oxadiazoles; Penicillamine; Protein Kinase Inhibitors; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Vasodilation; Vasodilator Agents | 1999 |
The nitric oxide donors, SNAP and DEA/NO, exert a negative inotropic effect in rat cardiomyocytes which is independent of cyclic GMP elevation.
Topics: Animals; Cardiotonic Agents; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Isoproterenol; Male; Myocardial Contraction; Myocardium; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxidation-Reduction; Penicillamine; Quinoxalines; Rats; Rats, Wistar | 1999 |
L-arginine limits myocardial cell death secondary to hypoxia-reoxygenation by a cGMP-dependent mechanism.
Topics: Animals; Arginine; Cell Death; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hypoxia; L-Lactate Dehydrogenase; Male; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Oxadiazoles; Oxygen Consumption; Quinoxalines; Rats; Rats, Sprague-Dawley | 1999 |
NO releases bombesin-like immunoreactivity from enteric synaptosomes by cross-activation of protein kinase A.
Topics: Animals; Arginine; Bombesin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Intestine, Small; Male; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Purinones; Quinoxalines; Rats; Rats, Wistar; Synaptosomes | 1999 |
Nitric oxide and cyclic GMP induce vesicle release at Drosophila neuromuscular junction.
Topics: Animals; Cyclic GMP; Drosophila melanogaster; Guanylate Cyclase; Immunohistochemistry; Larva; Neuromuscular Junction; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Presynaptic Terminals; Quinoxalines; Synaptic Vesicles | 1999 |
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Vasodilator Agents | 1999 |
Tonic inhibitory action by nitric oxide on spontaneous mechanical activity in rat proximal colon: involvement of cyclic GMP and apamin-sensitive K+ channels.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Potassium Channels; Purinones; Quinoxalines; Rats; Rats, Wistar | 1999 |
Pharmacological modulation of secondary mediator systems--cyclic AMP and cyclic GMP--on inflammatory hyperalgesia.
Topics: Animals; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Dinoprostone; Dopamine; Hyperalgesia; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Isoquinolines; Male; Oxadiazoles; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Rolipram; Second Messenger Systems; Sulfonamides; Tumor Necrosis Factor-alpha | 1999 |
Failure of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) to inhibit soluble guanylyl cyclase in rat ventricular cardiomyocytes.
Topics: Animals; Aorta, Thoracic; Carbachol; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Guanylate Cyclase; Heart Ventricles; In Vitro Techniques; Male; Myocardium; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Solubility | 1999 |
Effects of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) and Nomega(6)-nitro-L-arginine methyl ester (NAME) on cyclic GMP levels during muscarinic activation of tracheal smooth muscle.
Topics: Animals; Carbachol; Cattle; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscarinic Agonists; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Receptors, Muscarinic; Trachea | 1999 |
Release of nitric oxide within the coeliac plexus is involved in the organization of a gastroduodenal inhibitory reflex in the rabbit.
Topics: Action Potentials; Animals; Arginine; Benzoates; Celiac Plexus; Cyclic GMP; Duodenum; Enzyme Inhibitors; Female; Gastrointestinal Motility; Imidazoles; Male; Muscle, Smooth; Nitric Oxide; Nitroarginine; Oxadiazoles; Quinoxalines; Rabbits; Reflex; Stomach | 1999 |
Nitric oxide inhibits whole-cell current in cystic fibrosis pancreatic epithelial cells.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Calcium Channel Blockers; Cell Line; Charybdotoxin; Cyclic AMP; Cyclic GMP; Cystic Fibrosis; Diltiazem; Enzyme Inhibitors; Epithelial Cells; Glutathione; Humans; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Pancreas; Patch-Clamp Techniques; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; S-Nitrosoglutathione | 1999 |
Nitric oxide inhibits human aldosteronogenesis without guanylyl cyclase stimulation.
Topics: Adrenal Cortex; Aldosterone; Angiotensin II; Animals; Cell Line; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Hydroxycholesterols; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; PC12 Cells; Quinoxalines; Rats | 1999 |
Neuroprotective effects of DETA-NONOate, a nitric oxide donor, on hydrogen peroxide-induced neurotoxicity in cortical neurones.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Thionucleotides | 1999 |
Different signalling pathways mediate the opposite effects of endogenous versus exogenous nitric oxide on hydroperoxide toxicity in CHP100 neuroblastoma cells.
Topics: Caffeine; Calcium; Cell Survival; Cyclic GMP; Guanylate Cyclase; Humans; Kinetics; Neuroblastoma; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; tert-Butylhydroperoxide; Tumor Cells, Cultured | 1999 |
Effects of L-arginine on the afferent resting activity in the cephalopod statocyst.
Topics: Action Potentials; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arginine; Cyclic AMP; Cyclic GMP; Cystamine; DDT; Decapodiformes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Hair Cells, Vestibular; Imines; Immunosuppressive Agents; Male; Methylene Blue; Mollusca; NADP; NG-Nitroarginine Methyl Ester; Niacin; Nitric Oxide; Nitroarginine; Oxadiazoles; Postural Balance; Quinoxalines; Sodium Chloride | 1999 |
Cyclic GMP and cyclic AMP induced changes in control and hypertrophic cardiac myocyte function interact through cyclic GMP affected cyclic-AMP phosphodiesterases.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic GMP; Dogs; Heart; Milrinone; Oxadiazoles; Oxygen Consumption; Purinones; Quinoxalines | 1999 |
Activation of spinal N-methyl-D-aspartate receptors stimulates a nitric oxide/cyclic guanosine 3,5-monophosphate/glutamate release cascade in nociceptive signaling.
Topics: 2-Amino-5-phosphonovalerate; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanylate Cyclase; Male; Microdialysis; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Synaptic Transmission | 1999 |
Peroxynitrite is a positive inotropic agent in atrial and ventricular fibres of the frog heart.
Topics: Aminoquinolines; Animals; Atrial Function; Catalase; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Heart Ventricles; Hydroxyl Radical; Molsidomine; Muscle Fibers, Skeletal; Myocardial Contraction; Myocardium; Nitrates; Nitric Oxide Donors; Oxadiazoles; Oxidants; Quinoxalines; Rana esculenta; Sodium; Sodium-Calcium Exchanger; Ventricular Function | 1999 |
Contribution of 20-HETE to vasodilator actions of nitric oxide in the cerebral microcirculation.
Topics: Adenosine; Alkaloids; Amides; Animals; Basilar Artery; Carbazoles; Cerebrovascular Circulation; Cyclic GMP; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; Hydroxyeicosatetraenoic Acids; Indoles; Male; Microcirculation; Middle Cerebral Artery; Mixed Function Oxygenases; Nitric Oxide; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Sulfones; Vasodilation; Vasodilator Agents | 1999 |
5-hydroxytryptamine- and U46619-mediated vasoconstriction in bovine pulmonary conventional and supernumerary arteries: effect of endogenous nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Lung; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Serotonin; Serotonin Antagonists; Urea; Vasoconstrictor Agents | 2000 |
NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO.
Topics: Animals; Cattle; Colforsin; Cyclic GMP; Electron Transport; Enzyme Activation; Enzyme Inhibitors; Ferricyanides; Flavoproteins; Glutathione; Guanylate Cyclase; Heme; In Vitro Techniques; NADH, NADPH Oxidoreductases; NADP; Nitric Oxide; Oxadiazoles; Oxidation-Reduction; Penicillamine; Pentose Phosphate Pathway; Pulmonary Artery; Quinoxalines; Reactive Oxygen Species; Sulfhydryl Compounds | 1999 |
Inhaled NO reaches distal vasculatures to inhibit endothelium- but not leukocyte-dependent cell adhesion.
Topics: Administration, Inhalation; Animals; Capillary Permeability; Cats; Cell Adhesion; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Histamine; Hydrogen Peroxide; Leukocytes; Leukotriene B4; Lung; Microscopy, Video; Nitric Oxide; Oxadiazoles; Oxidants; Oxidative Stress; P-Selectin; Platelet Activating Factor; Quinoxalines | 1999 |
cGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Coronary Vessels; Cyclic GMP; Down-Regulation; Endothelium, Vascular; Feedback; Guanylate Cyclase; Hemoglobins; Humans; Isosorbide Dinitrate; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilator Agents | 1999 |
In vitro, nitric oxide (NO) stimulates LH secretion and partially prevents the inhibitory effect of dopamine on PRL release.
Topics: Aminoquinolines; Animals; Cells, Cultured; Cyclic GMP; Dopamine; Enzyme Inhibitors; Guanylate Cyclase; Luteinizing Hormone; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Pituitary Gland, Anterior; Prolactin; Quinoxalines; Rats; Rats, Wistar | 1999 |
Nitric oxide causes a cGMP-independent intracellular calcium rise in porcine endothelial cells-a paradox?
Topics: Animals; Aorta; Calcium; Calcium Channel Blockers; Cells, Cultured; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Space; Guanylate Cyclase; Hydrazines; Imidazoles; Intracellular Fluid; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Penicillamine; Quinoxalines; Spectrophotometry, Ultraviolet; Swine; Triazenes | 2000 |
Insulin inhibits migration of vascular smooth muscle cells with inducible nitric oxide synthase.
Topics: Animals; Cell Movement; Cells, Cultured; Cyclic GMP; Dogs; Enzyme Inhibitors; Female; Femoral Artery; Guanylate Cyclase; Hypoglycemic Agents; Insulin; Lipopolysaccharides; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines | 2000 |
Suppression of acute and chronic opioid withdrawal by a selective soluble guanylyl cyclase inhibitor.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acids; Guanylate Cyclase; Locus Coeruleus; Male; Morphine; Naloxone; Narcotic Antagonists; Opioid-Related Disorders; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome | 2000 |
Nitrergic relaxation of the mouse gastric fundus is mediated by cyclic GMP-dependent and ryanodine-sensitive mechanisms.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Caffeine; Calcium Channel Blockers; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Muscle Relaxation; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Quinoxalines; Ryanodine | 2000 |
Nitric oxide-induced cardioprotection in cultured rat ventricular myocytes.
Topics: Alkaloids; Animals; Animals, Newborn; Anti-Infective Agents; Benzophenanthridines; Cells, Cultured; Cyclic GMP; Dexamethasone; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Glucocorticoids; Glyburide; Heart Ventricles; Hypoglycemic Agents; Ischemic Preconditioning; Muscle Fibers, Skeletal; Myocardial Ischemia; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Oxadiazoles; Penicillamine; Phenanthridines; Potassium Channels; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley | 2000 |
Mediators of alkalosis-induced relaxation of piglet pulmonary veins.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Alkalosis; Animals; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Nitric Oxide; Nitroarginine; Oxadiazoles; Peptides; Potassium Channels; Pulmonary Veins; Quinoxalines; Swine; Vasoconstrictor Agents; Vasodilation | 2000 |
Sodium nitroprusside augments human lung fibroblast collagen gel contraction independently of NO-cGMP pathway.
Topics: Animals; Cell Line; Collagen; Cyclic GMP; Dinoprostone; Enzyme Inhibitors; Fetus; Fibroblasts; Fibronectins; Gels; Humans; Lung; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Penicillamine; Platelet Aggregation Inhibitors; Quinoxalines; Rats; Thionucleotides; Vasodilator Agents | 2000 |
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Meloxicam; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Thiazines; Thiazoles | 2000 |
Nitric oxide inhibits tumor necrosis factor-alpha-induced apoptosis by reducing the generation of ceramide.
Topics: Antigens, CD; Apoptosis; Caspase 8; Caspase 9; Caspases; Ceramides; Cyclic GMP; Enzyme Inhibitors; Humans; Kinetics; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Proteins; Quinoxalines; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type I; S-Nitroso-N-Acetylpenicillamine; Second Messenger Systems; Signal Transduction; Sphingosine; TNF Receptor-Associated Factor 1; Tumor Necrosis Factor-alpha; U937 Cells | 2000 |
Benzodifuroxan as an NO-dependent activator of soluble guanylate cyclase and a novel highly effective inhibitor of platelet aggregation.
Topics: Antihypertensive Agents; Blood Platelets; Cyclic GMP; Cyclic N-Oxides; Dithiothreitol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Guanylate Cyclase; Humans; Inhibitory Concentration 50; Nitric Oxide; Nitroprusside; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Sulfhydryl Compounds | 2000 |
Inhibition of the glutamate-induced K(+) current in identified Onchidium neurons by nitric oxide donors.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Membrane; Cyclic GMP; Enzyme Inhibitors; Ganglia, Invertebrate; Glutamic Acid; Hydrazines; Mollusca; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Potassium Channels; Quinoxalines; Vasodilator Agents | 2000 |
Pharmacological characterization of neurogenic responses of the sheep isolated internal anal sphincter.
Topics: Anal Canal; Animals; Autonomic Nervous System; Calcium; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Sheep | 2000 |
Kinetic characterization of the nitric oxide toxicity for PC12 cells: effect of half-life time of NO release.
Topics: Animals; Antioxidants; Ascorbic Acid; Cell Survival; Cyclic GMP; Cysteine; Dibutyryl Cyclic GMP; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Glutathione; Half-Life; Kinetics; Nitric Oxide; Nitro Compounds; Oxadiazoles; PC12 Cells; Quinoxalines; Rats; Time Factors | 2000 |
NO/cGMP pathway activation and membrane potential depolarization in pig ciliary epithelium.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Ciliary Body; Cyclic GMP; Guanylate Cyclase; Ion Channels; Membrane Potentials; Microelectrodes; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pigment Epithelium of Eye; Quinoxalines; Swine; Thionucleotides | 2000 |
Reduction in the level of cardiac cyclic GMP worsens contractile delay in myocardial stunning.
Topics: Animals; Coronary Circulation; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Myocardial Stunning; Myocardium; Nitric Oxide; Oxadiazoles; Oxygen Consumption; Quinoxalines; Rabbits | 2000 |
L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway.
Topics: Analgesics; Animals; Arginine; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Phosphodiesterase Inhibitors; Phthalazines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2000 |
1H-[1,2,4] oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) inhibits cyclic GMP-PKG pathway-independent nonadrenergic, noncholinergic relaxation in longitudinal muscle of the rectum of Wistar-ST rats.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Relaxation; Neuropeptides; Nitroarginine; Oxadiazoles; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Quinoxalines; Rats; Rats, Wistar; Rectum; Vasoactive Intestinal Peptide | 2000 |
Decreasing cyclic GMP exerts similar positive functional effects on cardiac myocytes regardless of initial level.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Heart; In Vitro Techniques; Myocardium; Oxadiazoles; Oxygen Consumption; Purinones; Quinoxalines; Rabbits | 2000 |
Role of cGMP versus 20-HETE in the vasodilator response to nitric oxide in rat cerebral arteries.
Topics: Animals; Cerebral Arteries; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 2000 |
Role of central glutamate receptors, nitric oxide and soluble guanylyl cyclase in the inhibition by endotoxin of rat gastric acid secretion.
Topics: Animals; Benzoates; Cyclic GMP; Dizocilpine Maleate; Dose-Response Relationship, Drug; Endotoxins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Gastric Acid; Gastric Mucosa; Glycine; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pentagastrin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Solubility; Stomach; Vagotomy | 2000 |
The biphasic effects of nitric oxide in primary rat osteoblasts are cGMP dependent.
Topics: Alkaline Phosphatase; Animals; Apoptosis; Cell Division; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Osteoblasts; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2000 |
Regulation of ciliary beat frequency by the nitric oxide-cyclic guanosine monophosphate signaling pathway in rat airway epithelial cells.
Topics: Alkaloids; Animals; Arginine; Carbazoles; Cells, Cultured; Cilia; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Glutathione; Indoles; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; omega-N-Methylarginine; Oxadiazoles; Purinones; Quinoxalines; Rats; S-Nitrosoglutathione; Signal Transduction; Trachea | 2000 |
Serotonin inhibition of the NMDA receptor/nitric oxide/cyclic GMP pathway in human neocortex slices: involvement of 5-HT(2C) and 5-HT(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylamines; Female; Humans; In Vitro Techniques; Indoles; Male; Middle Aged; N-Methylaspartate; Neocortex; Nitric Oxide; Nitroarginine; Oxadiazoles; Piperazines; Pyridines; Quinoxalines; Receptor, Serotonin, 5-HT2C; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Signal Transduction; Trazodone | 2000 |
Role of cGMP as a mediator of nerve-induced motor functions of the opossum esophagus.
Topics: Animals; Atropine; Cyclic GMP; Enteric Nervous System; Enzyme Inhibitors; Esophagogastric Junction; Female; Gastrointestinal Motility; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Fibers, Skeletal; Muscle, Smooth; Nitric Oxide; Opossums; Oxadiazoles; Parasympatholytics; Quinoxalines; Vasoactive Intestinal Peptide | 2000 |
Nitric oxide provokes tumor necrosis factor-alpha expression in adult feline myocardium through a cGMP-dependent pathway.
Topics: Animals; Benzoates; Cats; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA-Binding Proteins; Electrophoresis; I-kappa B Proteins; Imidazoles; In Vitro Techniques; Myocardium; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Phosphorylation; Protein Kinases; Quinoxalines; RNA, Messenger; Thionucleotides; Tumor Necrosis Factor-alpha | 2000 |
cGMP-independent inotropic effects of nitric oxide and peroxynitrite donors: potential role for nitrosylation.
Topics: Animals; Cyclic GMP; Diethylamines; Drug Combinations; Enzyme Inhibitors; Glutathione; In Vitro Techniques; Male; Molsidomine; Myocardial Contraction; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nucleotides, Cyclic; Oxadiazoles; Oxidation-Reduction; Quinoxalines; Rats; Rats, Wistar; Superoxide Dismutase | 2000 |
Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated adult guinea pig atria.
Topics: Age Factors; Animals; Aortic Bodies; Arginine; Blotting, Western; Carbachol; Cardiotonic Agents; Cyclic GMP; Digestive System; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Atria; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Ornithine; Oxadiazoles; Prosencephalon; Quinoxalines; Receptors, Atrial Natriuretic Factor; Time Factors | 2000 |
Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery.
Topics: Calcium Channels; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; In Vitro Techniques; Nifedipine; Nitric Oxide; Nitroprusside; Oxadiazoles; Oxygen; Potassium; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Receptors, Atrial Natriuretic Factor; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
Nitric oxide and cGMP influence axonogenesis of antennal pioneer neurons.
Topics: Animals; Axonal Transport; Axons; Cyclic GMP; Dihydrolipoamide Dehydrogenase; Embryo, Nonmammalian; Enzyme Inhibitors; Grasshoppers; Guanylate Cyclase; Horseradish Peroxidase; Indazoles; Morphogenesis; Nervous System; Neurons; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction | 2000 |
Cyclic GMP-independent relaxation of rat pulmonary artery by spermine NONOate, a diazeniumdiolate nitric oxide donor.
Topics: Animals; Cyclic GMP; Male; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; Spermine; Vasodilation | 2000 |
gamma-tocopherol partially protects insulin-secreting cells against functional inhibition by nitric oxide.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channels; Carbachol; Cell Division; Cell Line; Cell Survival; Cholinergic Agonists; Colforsin; Cyclic GMP; Enzyme Inhibitors; Insulin; Insulin Secretion; Insulinoma; Interleukin-1; Islets of Langerhans; Models, Chemical; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Phorbol Esters; Protein Kinase C; Quinoxalines; Rats; Spermine; Type C Phospholipases; Vitamin E | 2000 |
Inhibitory effect of cyclic guanosine 3',5'-monophosphate (cGMP) on the afferent resting activity in the cephalopod statocyst.
Topics: Afferent Pathways; Animals; Cyclic GMP; Cystamine; Decapodiformes; Dibutyryl Cyclic GMP; Dideoxyadenosine; Enzyme Inhibitors; Imines; Methylene Blue; Mollusca; NG-Nitroarginine Methyl Ester; Niacin; Nitroarginine; Oxadiazoles; Quinoxalines; Sense Organs | 2000 |
Nitric oxide modulates intracellular translocation of pigment organelles in Xenopus laevis melanophores.
Topics: Alkaloids; Animals; Arginine; Biological Transport; Blotting, Western; Carbazoles; Cells, Cultured; Cyclic GMP; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Guanylate Cyclase; Indoles; Melanophores; Microscopy, Fluorescence; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Signal Transduction; Time Factors; Xenopus laevis | 2000 |
Carbachol inhibits Na(+)-K(+)-ATPase activity in choroid plexus via stimulation of the NO/cGMP pathway.
Topics: Adenosine Triphosphate; Animals; Carbachol; Cattle; Cholinergic Agonists; Choroid Plexus; Cyclic GMP; Enzyme Inhibitors; Hydrolysis; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Ouabain; Oxadiazoles; Phosphorylation; Quinoxalines; Sodium-Potassium-Exchanging ATPase; Solubility; Thionucleotides; Triazenes; Vasodilator Agents | 2000 |
Nitric oxide: a trigger for classic preconditioning?
Topics: Adenosine Monophosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Epinephrine; Guanylate Cyclase; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Sympathomimetics; Vasodilator Agents | 2000 |
Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms.
Topics: Adenosine Diphosphate; Adult; Blood Platelets; Collagen; Cyclic GMP; Enzyme Inhibitors; Glucosamine; Glutathione; Humans; In Vitro Techniques; Kinetics; Models, Biological; Nitric Oxide Donors; Nitroglycerin; Nitroprusside; Nitroso Compounds; Oxadiazoles; Penicillamine; Platelet Aggregation; Platelet Aggregation Inhibitors; Quaternary Ammonium Compounds; Quinoxalines; S-Nitrosoglutathione | 2000 |
Nitric oxide modulation of interleukin-1[beta]-evoked intracellular Ca2+ release in human astrocytoma U-373 MG cells and brain striatal slices.
Topics: Aminoquinolines; Animals; Arginine; Astrocytoma; Calcium; Corpus Striatum; Cyclic GMP; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Heparin; Humans; Hydrazines; In Vitro Techniques; Interleukin-1; Intracellular Fluid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Ruthenium Red; Spermine; Tumor Cells, Cultured | 2000 |
Nitric oxide attenuates H(2)O(2)-induced endothelial barrier dysfunction: mechanisms of protection.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Oxidants; Penicillamine; Phosphodiesterase Inhibitors; Pulmonary Artery; Quinoxalines; Swine; Thionucleotides | 2001 |
Upregulation of the nitric oxide-cGMP pathway in aged myocardium: physiological response to l-arginine.
Topics: Aging; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Female; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Up-Regulation | 2001 |
Reduced vasorelaxant effect of carbon monoxide in diabetes and the underlying mechanisms.
Topics: 3-O-Methylglucose; Animals; Arteries; Calcium; Carbon Monoxide; Cells, Cultured; Cyclic GMP; Diabetes Mellitus, Experimental; Glucose; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Reference Values; Tail; Time Factors; Vasodilation; Vasodilator Agents | 2001 |
Whole brain spheroid cultures as a model to study the development of nitric oxide synthase-guanylate cyclase signal transduction.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Astrocytes; Atrial Natriuretic Factor; Brain; Cell Culture Techniques; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; N-Methylaspartate; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Pregnancy; Quinoxalines; Rats; Rats, Inbred Lew; Signal Transduction; Vasodilator Agents | 2000 |
Inhibitory effect of valves on endothelium-dependent relaxations to calcium ionophore in canine saphenous vein.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcimycin; Calcium; Colforsin; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hydrazines; In Vitro Techniques; Indomethacin; Ionophores; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Potassium Chloride; Quinoxalines; Saphenous Vein; Vasoconstrictor Agents; Vasodilation | 2001 |
Modulation of neuronal nitric oxide release by soluble guanylyl cyclase in guinea pig colon.
Topics: Animals; Arginine; Colon; Cyclic GMP; Dimethyl Sulfoxide; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Immunohistochemistry; Male; Muscle, Smooth; Neurons; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2001 |
Posttranscriptional regulation of human iNOS by the NO/cGMP pathway.
Topics: Cells, Cultured; Cyclic GMP; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Humans; Interleukin-1; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; RNA Stability; RNA, Messenger; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2001 |
NO/cGMP signaling modulates regulation of Na+-K+-ATPase activity by angiotensin II in rat proximal tubules.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Calcium; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Intracellular Membranes; Kidney Tubules, Proximal; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Solubility | 2001 |
Effect of NO donors on protein phosphorylation in intact vascular and nonvascular smooth muscles.
Topics: Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myometrium; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Phosphoproteins; Phosphorylation; Quinoxalines; Rats; S-Nitroso-N-Acetylpenicillamine; Vas Deferens | 2001 |
Opposing actions of nitric oxide on synaptic inputs of identified interneurones in the central nervous system of the crayfish.
Topics: Animals; Arginine; Astacoidea; Cyclic GMP; Cyclic N-Oxides; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Free Radical Scavengers; Ganglia, Invertebrate; Imidazoles; In Vitro Techniques; Interneurons; Male; Mechanoreceptors; Nerve Net; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Synapses; Synaptic Transmission | 2001 |
The dual effect of a nitric oxide donor in nociception.
Topics: Animals; Chronic Disease; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemoglobins; Injections, Spinal; Ligation; Male; Molsidomine; Nerve Compression Syndromes; Neuralgia; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Sciatic Nerve | 2001 |
Regulation of cardiac calcium current by NO and cGMP-modulating agents.
Topics: Adenine; Animals; Arginine; Biological Transport; Calcium Channels, L-Type; Carbachol; Cholinergic Agonists; Cyclic GMP; Cyclic N-Oxides; Enzyme Inhibitors; Exonucleases; Free Radical Scavengers; Guinea Pigs; Imidazoles; In Vitro Techniques; Myocardium; Nitric Oxide; omega-N-Methylarginine; Orchiectomy; Oxadiazoles; Quinoxalines; Receptors, Muscarinic | 2001 |
Rhythmicity of the cGMP-related signal transduction pathway in the mammalian circadian system.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alkaloids; Animals; Brain; Carbazoles; Circadian Rhythm; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Darkness; Enzyme Inhibitors; Indoles; Injections, Intraventricular; Isoenzymes; Light; Male; Mammals; Mesocricetus; Motor Activity; Oxadiazoles; Photoperiod; Quinoxalines; Signal Transduction; Suprachiasmatic Nucleus | 2001 |
Peroxynitrite leads to arteriolar smooth muscle cell membrane hyperpolarization and low vasoreactivity in severe shock.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Arginine; Arterioles; Charybdotoxin; Cyclic GMP; Drug Interactions; Female; Free Radical Scavengers; Glyburide; Guanidines; Ion Transport; Male; Membrane Potentials; Mesenteric Arteries; Microscopy, Confocal; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Nitrates; Nitric Oxide Donors; Norepinephrine; Oxadiazoles; Penicillamine; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Shock, Hemorrhagic; Vasodilator Agents | 2000 |
Mechanism of carbon monoxide-induced relaxation in the guinea pig ileal smooth muscle.
Topics: Animals; Calcium; Calcium Channels; Carbon Monoxide; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Patch-Clamp Techniques; Potassium Chloride; Quinoxalines; Signal Transduction | 2001 |
Differential regulation of contractility and nitric oxide sensitivity in gravid and nongravid myometrium during late pregnancy in a marsupial.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Female; Gestational Age; Guanylate Cyclase; Kinetics; Marsupialia; Myometrium; Nitric Oxide; Oxadiazoles; Oxytocin; Pregnancy; Quinoxalines; Uterine Contraction | 2001 |
Disruption of retinogeniculate pattern formation by inhibition of soluble guanylyl cyclase.
Topics: Aging; Alkaloids; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Ferrets; Geniculate Bodies; Guanylate Cyclase; In Vitro Techniques; Indoles; Neuropil; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Presynaptic Terminals; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Signal Transduction; Synaptophysin | 2001 |
Signaling pathway of nitric oxide-induced acrosome reaction in human spermatozoa.
Topics: Acrosome Reaction; Aminoquinolines; Calcium; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Humans; Male; Naphthalenes; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Protein Kinase C; Quinoxalines; Signal Transduction; Sperm Capacitation; Spermatozoa | 2001 |
N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcysteine; Adenosine Diphosphate; Adult; Calcimycin; Cell Membrane Permeability; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Humans; Ionomycin; Male; omega-N-Methylarginine; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Purinones; Quinoxalines | 2001 |
Nitric oxide regulates actin reorganization through cGMP and Ca(2+)/calmodulin in RAW 264.7 cells.
Topics: Actins; Animals; Bucladesine; Calcium; Calmodulin; Cell Line; Cyclic GMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Flow Cytometry; Interferon-gamma; Lipopolysaccharides; Mice; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Sulfonamides | 2001 |
The cerebrovascular response to elevated potassium--role of nitric oxide in the in vitro model of isolated rat middle cerebral arteries.
Topics: Animals; Brain Injuries; Cerebrovascular Circulation; Cyclic GMP; Enzyme Inhibitors; Extracellular Space; Male; Middle Cerebral Artery; Models, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Organ Culture Techniques; Oxadiazoles; Penicillamine; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Vasodilation | 2001 |
Neural regulation of in vitro giant contractions in the rat colon.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Antineoplastic Agents; Benzazepines; Calcium Channel Agonists; Calcium Channel Blockers; Colon; Cyclic GMP; Dopamine Antagonists; Enzyme Inhibitors; Hexamethonium; Imines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nicotinic Antagonists; Nitric Oxide; Nitroarginine; omega-Conotoxins; Oxadiazoles; Peristalsis; Quinoxalines; Rats; Rats, Sprague-Dawley; Suramin; Tetrodotoxin | 2001 |
The role of cGMP hydrolysing phosphodiesterases 1 and 5 in cerebral artery dilatation.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Basilar Artery; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Dipyridamole; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; In Vitro Techniques; Isoenzymes; Male; Milrinone; Nitroprusside; Oxadiazoles; Pentoxifylline; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Vasodilation; Vasodilator Agents | 2001 |
Nitric oxide modulates Ca(2+) channels in dorsal root ganglion neurons innervating rat urinary bladder.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Capsaicin; Cyclic GMP; Enzyme Inhibitors; Female; Ganglia, Spinal; Nerve Fibers; Nerve Fibers, Myelinated; Neurons, Afferent; Nimodipine; Nitric Oxide; Nitric Oxide Donors; omega-Conotoxin GVIA; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Urinary Bladder | 2001 |
Control of survival of proliferating L1210 cells by soluble guanylate cyclase and p44/42 mitogen-activated protein kinase modulators.
Topics: Animals; Apoptosis; Caspases; Cell Division; Cell Survival; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Imidazoles; Leukemia L1210; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxadiazoles; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-2; Pyridines; Quinoxalines; Signal Transduction; Tumor Cells, Cultured | 2001 |
Lipid hydroperoxide and cGMP are not involved in nitric oxide inhibition of steroidogenesis in bovine granulosa cells.
Topics: Animals; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Granulosa Cells; Guanylate Cyclase; Lipid Peroxidation; Lipid Peroxides; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Steroids | 2000 |
Nitric oxide directly activates GABA(A) receptor function through a cGMP/protein kinase-independent pathway in frog pituitary melanotrophs.
Topics: Aminoquinolines; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dithionitrobenzoic Acid; Electric Conductivity; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hydrazines; Ion Channel Gating; Male; Melanocytes; Membrane Potentials; Mercaptoethanol; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Nitroprusside; Oxadiazoles; Oxidation-Reduction; Patch-Clamp Techniques; Pituitary Gland; Quinoxalines; Rana ridibunda; Receptors, GABA-A; Sulfhydryl Reagents | 2001 |
NO-induced relaxation of labouring and non-labouring human myometrium is not mediated by cyclic GMP.
Topics: Charybdotoxin; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Labor, Obstetric; Molsidomine; Muscle Relaxation; Muscle, Smooth; Myometrium; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Oxytocin; Penicillamine; Peptides; Pregnancy; Quinoxalines; S-Nitrosothiols; Scorpion Venoms; Time Factors; Uterus | 2001 |
Nitric oxide-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea-pig in vitro.
Topics: Acetylcholine; Alkaloids; Animals; Bradycardia; Calcium Channel Blockers; Calcium Channels; Carbachol; Carbazoles; Cardiotonic Agents; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Heart Rate; In Vitro Techniques; Indoles; Isoquinolines; Milrinone; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; omega-Conotoxin GVIA; Oxadiazoles; Phosphorylation; Presynaptic Terminals; Quinoxalines; Sinoatrial Node; Sulfonamides; Synaptic Transmission; Tritium; Vagus Nerve | 2001 |
cGMP-mediated inhibition of cardiac L-type Ca(2+) current by a monoclonal antibody against the M(2) ACh receptor.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Antibodies, Monoclonal; Autoantibodies; Calcium Channels, L-Type; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanosine; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Isoproterenol; Membrane Potentials; Muscle Fibers, Skeletal; Myocardium; Oxadiazoles; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Receptor, Muscarinic M2; Receptors, Muscarinic | 2001 |
Exogenous nitric oxide causes potentiation of hippocampal synaptic transmission during low-frequency stimulation via the endogenous nitric oxide-cGMP pathway.
Topics: 2-Amino-5-phosphonovalerate; Adenosine Triphosphate; Animals; Cyanides; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanylate Cyclase; Hippocampus; Hydrazines; Long-Term Potentiation; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2001 |
Requirement of protein tyrosine phosphatase SHP2 for NO-stimulated vascular smooth muscle cell motility.
Topics: Animals; Aorta; Cell Movement; Cyclic GMP; Enzyme Inhibitors; Helminth Proteins; Male; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitric Oxide; Nitric Oxide Donors; Oligonucleotides, Antisense; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Up-Regulation | 2001 |
A xanthine-based KMUP-1 with cyclic GMP enhancing and K(+) channels opening activities in rat aortic smooth muscle.
Topics: Acetylcholine; Adenylyl Cyclases; Animals; Aorta; Aorta, Thoracic; Blood Pressure; Cells, Cultured; Cromakalim; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Heart Rate; In Vitro Techniques; Methylene Blue; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphoric Diester Hydrolases; Piperidines; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Solubility; Vasodilation; Vasodilator Agents; Xanthine; Xanthines | 2001 |
Renal interstitial cGMP mediates natriuresis by direct tubule mechanism.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Anesthesia; Animals; Arginine; Bacterial Toxins; Benzimidazoles; Consciousness; Cyclic AMP; Cyclic GMP; Enterotoxins; Escherichia coli Proteins; Female; Glomerular Filtration Rate; Kidney; Kidney Tubules; Microscopy, Fluorescence; Natriuresis; Nephrectomy; NG-Nitroarginine Methyl Ester; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium; Thionucleotides; Xanthenes | 2001 |
Mechanism of a nitric oxide donor NOR 1-induced relaxation in longitudinal muscle of rat proximal colon.
Topics: Animals; Calcium; Carbachol; Colon; Culture Techniques; Cyclic GMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Male; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Skeletal; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Thapsigargin; Thionucleotides | 2001 |
Nitric oxide contracts longitudinal smooth muscle of opossum oesophagus via excitation-contraction coupling.
Topics: Anesthetics, Local; Animals; Calcium Channel Blockers; Cyclic GMP; Enzyme Inhibitors; Esophagus; Female; In Vitro Techniques; Isometric Contraction; Male; Microelectrodes; Muscle, Smooth; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Opossums; Oxadiazoles; Quinoxalines; Signal Transduction; Tetrodotoxin; Triazenes | 2001 |
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization.
Topics: 1-Methyl-3-isobutylxanthine; Action Potentials; Alkaloids; Animals; Calcium; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Ion Channel Gating; Ion Transport; Ionomycin; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Nerve Tissue Proteins; Neuronal Plasticity; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Posterior; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Quinoxalines; Signal Transduction; Sodium; Sodium Channels; Sulfonamides; Thionucleotides | 2001 |
The nNOS/cGMP signal transducing system is involved in the cardiovascular responses induced by activation of NMDA receptors in the rostral ventrolateral medulla of cats.
Topics: Animals; Blood Pressure; Bradycardia; Cats; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Guanylate Cyclase; Heart Rate; Hypertension; Indazoles; Male; Medulla Oblongata; N-Methylaspartate; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2001 |
Nitric oxide regulates human eosinophil adhesion mechanisms in vitro by changing integrin expression and activity on the eosinophil cell surface.
Topics: Cell Adhesion; Cell Adhesion Molecules; Cell Separation; Cyclic GMP; Enzyme Inhibitors; Eosinophils; Fibronectins; Humans; Integrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines | 2001 |
Nitric oxide inhibition of cAMP synthesis in parotid acini: regulation of type 5/6 adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Isoenzymes; Isoproterenol; Mice; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Parotid Gland; Phosphoric Diester Hydrolases; Quinoxalines; Thapsigargin; Triazoles | 2001 |
NCX4016 (NO-Aspirin) has multiple inhibitory effects in LPS-stimulated human monocytes.
Topics: Aspirin; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibrinolytic Agents; Guanylate Cyclase; Humans; Interleukin-6; Lipopolysaccharides; Monocytes; Nitric Oxide; Oxadiazoles; Quinoxalines; Thromboplastin; Thromboxane B2; Tumor Necrosis Factor-alpha | 2001 |
Basal tonic release of nitric oxide coupled to cGMP production regulates the vascular reactivity of the mesenteric bed.
Topics: Acetylcholine; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Norepinephrine; Oxadiazoles; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Clonidine-induced nitric oxide-dependent vasorelaxation mediated by endothelial alpha(2)-adrenoceptor activation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Oxadiazoles; Oxidopamine; Phenylephrine; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Saponins; Sildenafil Citrate; Solubility; Sulfones; Sympatholytics; Time Factors; Vascular Resistance; Vasodilation; Vasodilator Agents; Yohimbine | 2001 |
Interleukin-1beta stimulates cyclic GMP efflux in brain astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Brain; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Interleukin-1; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Probenecid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Verapamil | 2001 |
Homogeneous segmental profile of carbon monoxide-mediated pulmonary vasodilation in rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Carbon Monoxide; Cyclic GMP; Dipyridamole; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Hypertension, Pulmonary; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Pulmonary Circulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vascular Resistance; Vasodilation | 2001 |
Expression of inducible nitric oxide synthase depresses beta-adrenergic-stimulated calcium release from the sarcoplasmic reticulum in intact ventricular myocytes.
Topics: Animals; Calcium; Colforsin; Cyclic GMP; Enzyme Inhibitors; Guanidines; Guanylate Cyclase; Heart Failure; Heart Ventricles; Humans; Lipopolysaccharides; Male; Middle Aged; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Sarcoplasmic Reticulum | 2001 |
Differential responses of newborn pulmonary arteries and veins to atrial and C-type natriuretic peptides.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Atrial Natriuretic Factor; Cyclic GMP; Gene Expression Regulation; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitric Oxide; Oxadiazoles; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Atrial Natriuretic Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sheep; Transcription, Genetic | 2002 |
NO/cGMP signaling and HSP90 activity represses metamorphosis in the sea urchin Lytechinus pictus.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Female; Guanylate Cyclase; HSP90 Heat-Shock Proteins; Lactones; Macrolides; Male; Metamorphosis, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Sea Urchins; Signal Transduction | 2001 |
Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells.
Topics: Animals; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Glucose; Humans; Immunoblotting; Mink; Models, Biological; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Quinoxalines; Rats; RNA, Messenger; Signal Transduction; Thionucleotides; Thrombospondin 1; Time Factors; Transfection; Transforming Growth Factor beta | 2002 |
Cyclic GMP-dependent vasodilatory properties of LASSBio 294 in rat aorta.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta, Thoracic; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Guanylate Cyclase; Hydrazones; In Vitro Techniques; Indomethacin; Male; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Thiophenes; Vasoconstriction; Vasodilator Agents | 2002 |
Effect of NO on EDHF response in rat middle cerebral arteries.
Topics: Adenosine Triphosphate; Animals; Biological Factors; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indomethacin; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Long-Evans; Thionucleotides; Vasodilation | 2002 |
Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats.
Topics: Acetylcholine; Animals; Antineoplastic Agents; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy Complications, Cardiovascular; Quinoxalines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
Nitric oxide induces resensitization of P2Y nucleotide receptors in cultured rat mesangial cells.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Glomerular Mesangium; Guanylate Cyclase; Intracellular Membranes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Osmolar Concentration; Oxadiazoles; Quinoxalines; Rats; Receptors, Purinergic P2; Ryanodine Receptor Calcium Release Channel | 2002 |
Phosphorylation of blood vessel vasodilator-stimulated phosphoprotein at serine 239 as a functional biochemical marker of endothelial nitric oxide/cyclic GMP signaling.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aorta; Biomarkers; Cell Adhesion Molecules; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Kinetics; Male; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphoproteins; Phosphorylation; Quinoxalines; Rabbits; Serine; Signal Transduction; Thionucleotides | 2002 |
Effect of nitric oxide donors and noradrenaline on Ca2+ release sites and global intracellular Ca2+ in myocytes from guinea-pig small mesenteric arteries.
Topics: Animals; Calcium; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Guinea Pigs; Intracellular Membranes; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroprusside; Norepinephrine; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine | 2002 |
Sodium nitroprusside stimulates L-DOPA release from striatal tissue through nitric oxide and cGMP.
Topics: Animals; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Levodopa; Male; Melatonin; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Salicylic Acid; Superoxide Dismutase; Uric Acid | 2002 |
Role of cyclic guanosine monophosphate in late preconditioning in conscious rabbits.
Topics: Animals; Consciousness; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Ischemic Preconditioning, Myocardial; Kinetics; Male; Myocardial Infarction; Myocardial Stunning; Oxadiazoles; Quinoxalines; Rabbits | 2002 |
Reduction of cGMP and nitric oxide has antidepressant-like effects in the forced swimming test in rats.
Topics: Animals; Antidepressive Agents, Tricyclic; Arginine; Cyclic GMP; Depression; Dimethyl Sulfoxide; Enzyme Inhibitors; Guanylate Cyclase; Imipramine; Indazoles; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Swimming | 2002 |
Effects of nitric oxide on P2Y receptor resensitization in spontaneously hypertensive rat mesangial cells.
Topics: Adenosine Triphosphate; Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Cytosol; Enzyme Inhibitors; Glomerular Mesangium; Guanylate Cyclase; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrogen Oxides; Osmolar Concentration; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Purinergic P2; Spermine | 2002 |
Involvement of NO in the endothelium-independent relaxing effects of N(omega)-hydroxy-L-arginine and other compounds bearing a C=NOH function in the rat aorta.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indicators and Reagents; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NADPH-Ferrihemoprotein Reductase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organic Cation Transport Proteins; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2002 |
Nitric oxide inhibits capacitative Ca2+ entry by suppression of mitochondrial Ca2+ handling.
Topics: Barium; Calcium; Cell Line; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Humans; Intracellular Membranes; Membrane Potentials; Mitochondria; Molsidomine; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Oxygen Consumption; Peroxynitrous Acid; Quinoxalines; Thapsigargin; Time Factors | 2002 |
Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
Topics: Adenosine Diphosphate; Animals; Catalase; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Guanylate Cyclase; Hydrazines; In Vitro Techniques; Indazoles; Male; Nitric Oxide Donors; Oxadiazoles; Platelet Aggregation; Platelet Aggregation Inhibitors; Pulmonary Artery; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thapsigargin; Thionucleotides; Vasoconstriction | 2002 |
Role of the nitric oxide-cyclic GMP-K+ channel pathway in the antinociception induced by atrial natriuretic peptide (ANP) and diclofenac.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrial Natriuretic Factor; Charybdotoxin; Cyclic GMP; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain Measurement; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Tolbutamide | 2002 |
Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity.
Topics: Animals; Aorta, Thoracic; Chromatography, High Pressure Liquid; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Free Radical Scavengers; Guanylate Cyclase; Inflammation; Linoleic Acids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Nitro Compounds; Oxadiazoles; Oxidation-Reduction; Oxyhemoglobins; Quinoxalines; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Vasodilation | 2002 |
Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP.
Topics: Animals; CD8-Positive T-Lymphocytes; Cells, Cultured; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation; Guanylate Cyclase; Humans; Male; Mice; Mice, Inbred BALB C; Models, Immunological; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroso Compounds; Oxadiazoles; Polymerase Chain Reaction; Quinoxalines; Receptors, Interleukin; Receptors, Interleukin-12; Receptors, Interleukin-4; Signal Transduction; Th1 Cells; Th2 Cells | 2002 |
YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indazoles; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitroprusside; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Quinoxalines; Rabbits; Rats; Rats, Wistar; Signal Transduction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
Mechanisms underlying the hydrogen peroxide-induced, endothelium-independent relaxation of the norepinephrine-contraction in guinea-pig aorta.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Guinea Pigs; Hydrogen Peroxide; In Vitro Techniques; Male; Methylene Blue; Myosin Light Chains; Nitroglycerin; Norepinephrine; Oxadiazoles; Phosphorylation; Purinones; Quinoxalines; Rats; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Comparative analysis of nitric oxide and SALMFamide neuropeptides as general muscle relaxants in starfish.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Muscle Relaxation; Neuropeptides; Nitric Oxide; Oxadiazoles; Quinoxalines; Radioimmunoassay; Starfish; Stomach | 2003 |
Incubation of porcine iris-ciliary bodies to study the mechanisms by which nitric oxide donors lower intraocular pressure.
Topics: Animals; Captopril; Ciliary Body; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intraocular Pressure; Iris; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitro Compounds; Nitrogen Oxides; Oxadiazoles; Penicillamine; Phosphodiesterase Inhibitors; Purinones; Quinoxalines; Rabbits; S-Nitrosothiols; Spermine; Swine; Time Factors | 2003 |
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide.
Topics: 3T3 Cells; 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adipose Tissue, Brown; Animals; Cold Temperature; Cyclic GMP; DNA-Binding Proteins; DNA, Mitochondrial; Eating; Energy Metabolism; Female; HeLa Cells; High Mobility Group Proteins; Humans; Male; Mice; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Motor Activity; NF-E2-Related Factor 1; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nuclear Proteins; Nuclear Respiratory Factors; Oligonucleotides, Antisense; Oxadiazoles; Oxygen Consumption; Penicillamine; Quinoxalines; Rats; RNA, Messenger; Signal Transduction; Trans-Activators; Transcription Factors; U937 Cells; Weight Gain | 2003 |
Effects of nitric oxide and cGMP on inhibin A and inhibin subunit mRNA levels from cultured rat granulosa cells.
Topics: Animals; Blotting, Northern; Colforsin; Cyclic GMP; Dibutyryl Cyclic GMP; Enzyme Inhibitors; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Inhibins; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2003 |
Two distinct effects of cGMP on cytosolic Ca2+ concentration of rat pancreatic beta-cells.
Topics: 4-Aminopyridine; Animals; Calcium; Cyclic GMP; Cytosol; Dimethyl Sulfoxide; Enzyme Inhibitors; Glucose; Hydrazines; Hypoglycemic Agents; Islets of Langerhans; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Potassium; Potassium Channel Blockers; Quinoxalines; Rats; Tolbutamide | 2003 |
Hypoxia enhances a cGMP-independent nitric oxide relaxing mechanism in pulmonary arteries.
Topics: Animals; Cattle; Cell Hypoxia; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pulmonary Artery; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Tetraethylammonium; Vasodilation | 2003 |
Cyclic GMP mediates influence of macula densa nitric oxide over tubuloglomerular feedback.
Topics: Animals; Citrulline; Cyclic GMP; Enzyme Inhibitors; Feedback, Physiological; Glomerular Filtration Rate; Guanylate Cyclase; Juxtaglomerular Apparatus; Male; Nephrons; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Thiourea | 2003 |
Opposite nociceptive effects of the arginine/NO/cGMP pathway stimulation in dermal and subcutaneous tissues.
Topics: Animals; Arginine; Bucladesine; Cyclic GMP; Dermis; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Subcutaneous; Male; Molsidomine; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Subcutaneous Tissue; Time Factors | 2003 |
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Homeostasis; In Vitro Techniques; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Male; Mice; Mice, Knockout; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; RNA, Messenger; Solubility | 2003 |
Effect of nitric oxide on lung surfactant secretion.
Topics: Animals; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Guanidines; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Perfusion; Phosphatidylcholines; Pulmonary Alveoli; Pulmonary Surfactants; Quinoxalines; Rats; Rats, Sprague-Dawley; Spermine | 2003 |
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta, Thoracic; Atrial Natriuretic Factor; Cyclic GMP; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Guanylate Cyclase; Male; Mesenteric Arteries; Mice; Mice, Inbred Strains; Mice, Knockout; Muscle Relaxation; Natriuretic Peptide, C-Type; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrogen Oxides; Nitroglycerin; Oxadiazoles; Phenylephrine; Polysaccharides; Quinoxalines; Receptors, Atrial Natriuretic Factor; Signal Transduction; Spermine | 2003 |
Nitric oxide and cGMP activate the Ras-MAP kinase pathway-stimulating protein tyrosine phosphorylation in rabbit aortic endothelial cells.
Topics: Animals; Aorta; Blotting, Western; Carbazoles; Cyclic GMP; Cytosol; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Free Radicals; Genes, Dominant; Glutathione Transferase; Indoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphorylation; Precipitin Tests; Proto-Oncogene Proteins p21(ras); Quinoxalines; Rabbits; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Transfection; Tyrosine | 2003 |
Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blotting, Western; Cells, Cultured; Chemokine CCL2; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Gene Expression Regulation; Guanylate Cyclase; Inflammation Mediators; Luciferases; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; NF-kappa B; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Transcription, Genetic; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2003 |
Ethanol stimulates ciliary beating by dual cyclic nucleotide kinase activation in bovine bronchial epithelial cells.
Topics: Animals; Bronchi; Cattle; Cells, Cultured; Cilia; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Ethanol; Guanylate Cyclase; Nitric Oxide; Oxadiazoles; Quinoxalines; Thionucleotides | 2003 |
G protein-coupled endothelial receptor for atypical cannabinoid ligands modulates a Ca2+-dependent K+ current.
Topics: Animals; Arteries; Calcium; Cannabinoids; Carbazoles; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endothelium; Endothelium, Vascular; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Guanylate Cyclase; Humans; Indoles; Kinetics; Ligands; Male; Membrane Potentials; Oxadiazoles; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Resorcinols; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Umbilical Veins; Vasodilator Agents | 2003 |
Nitric oxide and cyclic GMP increase the expression of matrix metalloproteinase-9 in vascular smooth muscle.
Topics: Animals; Cells, Cultured; Cyclic GMP; Cyclooxygenase 2; Isoenzymes; Lipopolysaccharides; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; RNA, Messenger; Superoxide Dismutase | 2003 |
Influence of drugs acting on nitric oxide-dependent pathways on ethanol tolerance in rats.
Topics: Aminoquinolines; Animals; Cyclic GMP; Drug Tolerance; Enzyme Inhibitors; Ethanol; Guanylate Cyclase; Male; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar | 2003 |
The vasorelaxation of Antrodia camphorata mycelia: involvement of endothelial Ca(2+)-NO-cGMP pathway.
Topics: Adenosine; Aorta, Thoracic; Basidiomycota; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Medicine, Chinese Traditional; Mycelium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Plant Extracts; Plants, Medicinal; Quinoxalines; Species Specificity; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2003 |
Burn-induced lung damage in rat is mediated by a nitric oxide/cGMP system.
Topics: Animals; Base Sequence; Burns; Cyclic GMP; Enzyme Inhibitors; Female; Gene Expression; Guanylate Cyclase; Lung; Lung Injury; Male; Methylene Blue; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitroprusside; Oxadiazoles; Peroxidase; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 2003 |
Role of the nitric oxide-cyclic GMP pathway in regulation of vaginal blood flow.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Female; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Regional Blood Flow; Sexual Behavior, Animal; Sildenafil Citrate; Sulfones; Vagina | 2003 |
Guanylyl cyclase inhibitors NS2028 and ODQ and protein kinase G (PKG) inhibitor KT5823 trigger apoptotic DNA fragmentation in immortalized uterine epithelial cells: anti-apoptotic effects of basal cGMP/PKG.
Topics: Animals; Apoptosis; Carbazoles; Cell Line, Transformed; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; DNA; DNA Fragmentation; Enzyme Inhibitors; Epithelial Cells; Female; Guanylate Cyclase; Indoles; Oxadiazoles; Oxazines; Quinoxalines; Signal Transduction; Uterus | 2003 |
Activation of nitric oxide-cyclic guanosine monophosphate signaling in kidney by extracorporeal shock wave therapy.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Kidney; Lithotripsy; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxadiazoles; Quinoxalines; Rabbits; Signal Transduction | 2003 |
Pertussis toxin-sensitive G protein but not NO/cGMP pathway mediates the negative inotropic effect of carbachol in adult rat cardiomyocytes.
Topics: Adenylyl Cyclases; Animals; Carbachol; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Electric Stimulation; GTP-Binding Proteins; Injections, Intraperitoneal; Isoproterenol; Male; Myocardial Contraction; Myocytes, Cardiac; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Pertussis Toxin; Quinoxalines; Rats; Time Factors | 2004 |
NO/cyclic GMP pathway mediates the relaxation of feline lower oesophageal sphincter.
Topics: Aminoquinolines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cats; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Esophagogastric Junction; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Signal Transduction; Vasoactive Intestinal Peptide | 2003 |
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid | 2003 |
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle.
Topics: Adenine; Adenylyl Cyclases; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; GTP-Binding Proteins; Guanylate Cyclase; Indoles; Male; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Procaterol; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Suramin; Xamoterol | 2004 |
Nitric oxide release from human corpus cavernosum induced by a purified scorpion toxin.
Topics: Adolescent; Adult; Child; Cyclic GMP; Drug Evaluation, Preclinical; Electric Stimulation; Enzyme Inhibitors; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penis; Phenylephrine; Piperazines; Priapism; Purines; Quinoxalines; Scorpion Venoms; Second Messenger Systems; Sildenafil Citrate; Sodium Channel Blockers; Sulfones; Tetrodotoxin | 2004 |
Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2 levels: essential role of cGMP.
Topics: Animals; Animals, Newborn; Antioxidants; Aorta, Thoracic; Catalase; Cell Movement; Cells, Cultured; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Female; Guanylate Cyclase; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Insulin-Like Growth Factor I; Muscle, Smooth, Vascular; NADPH Oxidases; Nitric Oxide; Oxadiazoles; Oxidants; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Sprague-Dawley | 2004 |
Evidence that nitroprusside stimulates glucose uptake in isolated rat cardiomyocytes via mitogen-activated protein kinase.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ferricyanides; Flavonoids; Glucose; Imidazoles; Male; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Spermine | 2003 |
High and low gain switches for regulation of cAMP efflux concentration: distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenine; Animals; Atrial Natriuretic Factor; Biological Transport; Cardiac Pacing, Artificial; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Inhibitors; Guanylate Cyclase; Heart Atria; Milrinone; Molsidomine; Myocardial Contraction; Myocytes, Cardiac; Natriuretic Peptide, C-Type; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyridines; Quinoxalines; Rabbits; Receptors, Cytoplasmic and Nuclear; Second Messenger Systems; Soluble Guanylyl Cyclase; Stroke Volume | 2004 |
Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway.
Topics: Adenosine Triphosphate; Analgesics; Animals; Arginine; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Indoles; Male; Nitric Oxide; Nociceptors; omega-N-Methylarginine; Oxadiazoles; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
Identification of manganese superoxide dismutase as a NO-regulated gene in rat glomerular mesangial cells by 2D gel electrophoresis.
Topics: Animals; Blotting, Northern; Blotting, Western; Cyclic GMP; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glomerular Mesangium; Lysine; Male; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; RNA, Messenger; S-Nitroso-N-Acetylpenicillamine; Superoxide Dismutase; Triazenes; Up-Regulation | 2003 |
Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Topics: Adrenalectomy; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Denervation; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Guanylate Cyclase; Hypertension; Ion Transport; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Natriuresis; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sodium; Soluble Guanylyl Cyclase; Thionucleotides | 2004 |
Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade.
Topics: Animals; Cyclic GMP; Drug Combinations; Dura Mater; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Male; Mechanoreceptors; Neural Inhibition; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nociceptors; Oxadiazoles; Physical Stimulation; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thionucleotides | 2004 |
Involvement of NO/cGMP pathway in toluene-induced locomotor hyperactivity in female rats.
Topics: Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Hyperkinesis; Injections, Intraperitoneal; Motor Activity; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toluene | 2004 |
Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
Topics: Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Female; Interleukin-6; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy, Animal; Progesterone; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2004 |
Nitric oxide activates glibenclamide-sensitive K+ channels in urinary bladder myocytes through a c-GMP-dependent mechanism.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Guinea Pigs; Indoles; Ion Channel Gating; Male; Membrane Potentials; Molsidomine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Potassium Channels; Quinoxalines; Signal Transduction; Urinary Bladder | 2004 |
Role of cyclic GMP in nitrous-oxide-induced anxiolytic-like behavior in the mouse light-dark exploration test.
Topics: Animals; Anxiety; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Exploratory Behavior; Male; Mice; Nitrous Oxide; Oxadiazoles; Periodicity; Phosphodiesterase Inhibitors; Purinones; Quinoxalines | 2004 |
The permissive role of endothelial NO in CO-induced cerebrovascular dilation.
Topics: Animals; Arterioles; Carbon Monoxide; Cerebral Arteries; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Nitroprusside; Oxadiazoles; Pia Mater; Potassium Channel Blockers; Quinoxalines; Swine; Tetraethylammonium; Vasodilation | 2004 |
A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia.
Topics: Allosteric Regulation; Ammonia; Animals; Binding Sites; Corpus Striatum; Cyclic GMP; Glycine; Male; Microdialysis; Microinjections; Neurons; Neurotoxins; Nitric Oxide; Organophosphonates; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2004 |
Nitric oxide modulates local reflexes of the tailfan of the crayfish.
Topics: Analysis of Variance; Animals; Arginine; Astacoidea; Cyclic GMP; Cyclic N-Oxides; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Free Radical Scavengers; Imidazoles; In Vitro Techniques; Male; Muscles; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Picolines; Quinoxalines; Reflex; Thionucleotides | 2004 |
Nitric oxide regulates the levels of cGMP accumulation in the cricket brain.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cyclic GMP; Enzyme-Linked Immunosorbent Assay; Gryllidae; Guanylate Cyclase; Immunohistochemistry; Nitric Oxide; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sodium Chloride; Soluble Guanylyl Cyclase | 2004 |
Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver.
Topics: Acetylcholine; Animals; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Injections, Intravenous; Insulin Resistance; Liver; Male; Molsidomine; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Portal Vein; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2004 |
Nitric oxide inhibits complex I following AMPA receptor activation via peroxynitrite.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Benzothiadiazines; Cells, Cultured; Cyclic GMP; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Immunohistochemistry; Kainic Acid; Microtubule-Associated Proteins; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peroxynitrous Acid; Proton Pumps; Quinoxalines; Rats; Receptors, AMPA; Tyrosine | 2004 |
Cytokines, nitric oxide, and cGMP modulate the permeability of an in vitro model of the human blood-brain barrier.
Topics: Blood-Brain Barrier; Capillary Permeability; Cells, Cultured; Cyclic GMP; Cytokines; Electric Impedance; Endothelial Cells; Enzyme Inhibitors; Humans; Immunohistochemistry; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Nitroso Compounds; Oxadiazoles; Quinoxalines; Signal Transduction | 2004 |
Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
Topics: Acetylcholine; Animals; Biological Factors; Carotid Arteries; Cyclic GMP; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epoprostenol; Hemoglobins; Hypertension, Renovascular; Indomethacin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rats; Rats, Wistar; Vasodilator Agents | 2004 |
Nitric oxide-cyclic GMP contributes to abnormal activation of Na+-K+-ATPase in the aorta from rats with endotoxic shock.
Topics: Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Dose-Response Relationship, Drug; Endotoxemia; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Male; Nitrates; Nitric Oxide; Ouabain; Oxadiazoles; Potassium; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred WKY; Shock, Septic; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Tetradecanoylphorbol Acetate; Time Factors | 2005 |
Nitric oxide-dependent and nitric oxide-independent transcriptional responses to high shear stress in endothelial cells.
Topics: Binding Sites; Cyclic GMP; DNA-Binding Proteins; Early Growth Response Protein 1; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation; Guanylate Cyclase; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; High Mobility Group Proteins; Humans; Immediate-Early Proteins; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nuclear Proteins; Oxadiazoles; Quinoxalines; SOX9 Transcription Factor; SOXD Transcription Factors; Stress, Mechanical; Transcription Factors; Transcription, Genetic | 2005 |
Involvement of a nitric oxide-cyclic guanosine monophosphate pathway in control of fallopian tube contractility.
Topics: Adult; Cyclic GMP; Enzyme Inhibitors; Fallopian Tubes; Female; Guanylate Cyclase; Humans; In Vitro Techniques; Methylene Blue; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Spermine | 2004 |
BAY 41-2272 [5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4-ylamine]-induced dilation in ovine pulmonary artery: role of sodium pump.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Oxadiazoles; Pulmonary Artery; Pyrazoles; Pyridines; Quinoxalines; Rubidium Radioisotopes; Serotonin; Sheep; Sodium-Potassium-Exchanging ATPase; Vasoconstriction; Vasodilation | 2005 |
Hemin induces active chloride secretion in Caco-2 cells.
Topics: Caco-2 Cells; Carbon Monoxide; Chlorides; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Epithelium; Hemin; Homeostasis; Humans; Ouabain; Oxadiazoles; Quinoxalines; Sodium; Water-Electrolyte Balance | 2005 |
Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.
Topics: Acute-Phase Proteins; Animals; Apoptosis; Carrier Proteins; Cells, Cultured; Culture Media, Conditioned; Cyclic GMP; Cytokines; DNA; Endotoxins; Enzyme Inhibitors; Hepatocytes; Lipopolysaccharide Receptors; Lipopolysaccharides; Liver; Male; Membrane Glycoproteins; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Toll-Like Receptors | 2005 |
Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes.
Topics: Animals; Caffeine; Carbachol; Chelating Agents; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Egtazic Acid; Guinea Pigs; Ileum; In Vitro Techniques; Membrane Potentials; Muscarinic Agonists; Muscle Contraction; Myocytes, Smooth Muscle; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Quinoxalines; Type C Phospholipases | 2005 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Formation of releasable NO stores by S-nitrosoglutathione in arteries exhibiting tolerance to glyceryl-trinitrate.
Topics: Acetylcysteine; Analysis of Variance; Animals; Aorta, Thoracic; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Nitric Oxide; Nitrogen Oxides; Nitroglycerin; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; S-Nitrosoglutathione; Superoxide Dismutase; Thionucleotides; Vasoconstriction; Vasodilation | 2005 |
Nitric oxide reduces T lymphocyte adhesion to human brain microvessel endothelial cells via a cGMP-dependent pathway.
Topics: Brain; Cell Adhesion; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; E-Selectin; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; Humans; Intercellular Adhesion Molecule-1; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Nitroso Compounds; Oxadiazoles; Platelet Endothelial Cell Adhesion Molecule-1; Quinoxalines; Signal Transduction; T-Lymphocytes; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2005 |
Cross-talk between adenosine and the oxatriazole derivative GEA 3175 in platelets.
Topics: Adenosine; Blood Platelets; Calcium; Cyclic AMP; Cyclic GMP; Cytosol; Drug Interactions; Enzyme Inhibitors; Guanylate Cyclase; Humans; Milrinone; Oxadiazoles; Phosphodiesterase Inhibitors; Platelet Aggregation; Platelet Aggregation Inhibitors; Quinoxalines; Thrombin; Time Factors; Triazoles | 2005 |
Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits.
Topics: Acetophenones; Allopurinol; Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypercholesterolemia; In Vitro Techniques; Male; Muscle Relaxation; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Onium Compounds; Oxadiazoles; Penis; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rabbits; Rotenone; Sildenafil Citrate; Sulfones; Superoxides; Uncoupling Agents; Xanthine Oxidase | 2005 |
Nomega-hydroxy-L-arginine homologues and hydroxylamine as nitric oxide-dependent vasorelaxant agents.
Topics: Animals; Aorta, Thoracic; Arginine; Cyclic GMP; Cyclic N-Oxides; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Hydroxylamine; Imidazoles; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Vasodilation; Vasodilator Agents | 2005 |
Sildenafil citrate and sildenafil nitrate (NCX 911) are potent inhibitors of superoxide formation and gp91phox expression in porcine pulmonary artery endothelial cells.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cells, Cultured; Cyclic GMP; Endothelial Cells; Guanylate Cyclase; Male; Membrane Glycoproteins; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Oxadiazoles; Piperazines; Protein Kinase Inhibitors; Pulmonary Artery; Purines; Quinoxalines; Sildenafil Citrate; Sulfones; Superoxides; Swine; Thionucleotides | 2005 |
Involvement of guanylyl cyclase, protein kinase A and Na+ K+ ATPase in relaxations of bovine isolated bronchioles induced by GEA 3175, an NO donor.
Topics: Animals; Bronchi; Calcium; Cattle; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Molsidomine; Muscle Relaxation; Nitric Oxide; Nitric Oxide Donors; Ouabain; Oxadiazoles; Peptides; Potassium; Quinoxalines; S-Nitrosoglutathione; Serotonin; Sodium-Potassium-Exchanging ATPase; Thionucleotides; Triazoles | 2006 |
Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.
Topics: Animals; Carbazoles; Cyclic GMP; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Endothelin-3; Hypothalamus, Anterior; Indazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroprusside; Oligopeptides; Oxadiazoles; Piperidines; Quinoxalines; Rats; Suramin; Tyrosine 3-Monooxygenase | 2005 |
Lysozyme binding to endocardial endothelium mediates myocardial depression by the nitric oxide guanosine 3',5' monophosphate pathway in sepsis.
Topics: Animals; Cell Membrane; Cyclic GMP; Dogs; Endocardium; Endothelium; In Vitro Techniques; Muramidase; Myocardial Contraction; Myocardium; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Sepsis | 2005 |
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Reaction Time; Spinal Cord; Time Factors; Vincristine | 2005 |
Interference of neutrophil-platelet interaction by YC-1: a cGMP-dependent manner on heterotypic cell-cell interaction.
Topics: Adult; Antibodies; Blood Platelets; Calcium; Cathepsin G; Cathepsins; Cell Adhesion; Cell Communication; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Flow Cytometry; Guanylate Cyclase; Humans; Indazoles; Intracellular Space; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxadiazoles; P-Selectin; Quinoxalines; Serine Endopeptidases; Time Factors | 2005 |
Lack of the nitric oxide-cyclic GMP-potassium channel pathway for the antinociceptive effect of intrathecal zaprinast in a rat formalin test.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analgesics; Animals; Cyclic GMP; Formaldehyde; Glyburide; Injections, Spinal; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Potassium Channels; Purinones; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction | 2005 |
Expression and functional role of the RhoA/Rho-kinase pathway in rat coeliac artery.
Topics: Amides; Animals; Blotting, Western; Celiac Artery; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Guanine Nucleotide Exchange Factors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phenylephrine; Potassium; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Rho Guanine Nucleotide Exchange Factors; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA, Messenger; Signal Transduction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Dual actions of dephostatin on the nitric oxide/cGMP-signalling pathway in porcine iliac arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blotting, Western; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Hydroquinones; Iliac Artery; In Vitro Techniques; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Penicillamine; Phenylephrine; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinoxalines; Serine; Signal Transduction; Swine; Triazoles; Tyrosine; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Phosphodiesterase 5 and effects of sildenafil on cerebral arteries of man and guinea pig.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Aged; Aged, 80 and over; Animals; Basilar Artery; Blotting, Western; Cerebral Arteries; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Guinea Pigs; Humans; Hydrolysis; In Vitro Techniques; Infant; Male; Morpholines; Muscle, Smooth, Vascular; Nitroprusside; Oxadiazoles; Piperazines; Purines; Pyrazoles; Pyrimidines; Pyrimidinones; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sildenafil Citrate; Sulfones; Vasodilation; Vasodilator Agents | 2005 |
Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway.
Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Blotting, Western; Carotid Arteries; Cell Adhesion; Cell Line; Chemokine CCL2; Cyclic GMP; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Hydrolyzable Tannins; In Vitro Techniques; Intercellular Adhesion Molecule-1; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Paeonia; Plant Bark; Plant Roots; Quinoxalines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Necrosis Factor-alpha; U937 Cells; Umbilical Veins; Vascular Cell Adhesion Molecule-1; Vasodilation; Vasodilator Agents | 2005 |
Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation.
Topics: Adenoviridae; Animals; Calcium Signaling; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Humans; Hydrazines; Hypertension, Portal; Liver; Male; Nitric Oxide; Nitrogen Oxides; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Transduction, Genetic | 2006 |
Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.
Topics: Adenoviridae; Apoptosis; Atrial Natriuretic Factor; bcl-2-Associated X Protein; Benzothiazoles; Caspase 3; Caspases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Activation; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Half-Life; Humans; Mutation; Ovarian Neoplasms; Oxadiazoles; Phosphorylation; Proto-Oncogene Proteins c-mdm2; Quinoxalines; RNA, Small Interfering; Serine; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide.
Topics: Animals; Carbachol; Carbolines; Colforsin; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroglycerin; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Tadalafil; Tetrodotoxin | 2006 |
Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms.
Topics: Animals; Basilar Artery; Brain Stem; Calcium Chloride; Cyclic AMP; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Male; NG-Nitroarginine Methyl Ester; Ouabain; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Serotonin; Sildenafil Citrate; Sulfones; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2006 |
Photoimmunoprotection by UVA (320-400 nm) radiation is determined by UVA dose and is associated with cutaneous cyclic guanosine monophosphate.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Dermatitis, Contact; Dose-Response Relationship, Radiation; Enzyme Activation; Female; Guanylate Cyclase; Immune Tolerance; Mice; Mice, Inbred Strains; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Quinoxalines; Sildenafil Citrate; Skin; Sulfones; Ultraviolet Rays | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
The nitric oxide-guanosine 3',5'-cyclic monophosphate pathway regulates dopamine efflux in the medial preoptic area and copulation in male rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Copulation; Cyclic GMP; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Guanosine Monophosphate; Homovanillic Acid; Male; Microdialysis; Models, Biological; Nitric Oxide; Oxadiazoles; Preoptic Area; Quinoxalines; Rats; Rats, Long-Evans; Signal Transduction | 2006 |
Nitric oxide donor-induced persistent inhibition of cell adhesion protein expression and NFkappaB activation in endothelial cells.
Topics: Cell Adhesion Molecules; Cells, Cultured; Cyclic GMP; Cysteine; Endothelial Cells; Guanylate Cyclase; Humans; I-kappa B Kinase; I-kappa B Proteins; Interleukin-1; Lipopolysaccharides; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Thionucleotides; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2006 |
Direct effects of nitric oxide on histamine release from rat enterochromaffin-like cells.
Topics: Animals; Calcium; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enterochromaffin-like Cells; Enzyme Inhibitors; Gastrins; Guanylate Cyclase; Histamine; Histamine Release; Male; Nitric Oxide; Nitric Oxide Donors; Nitro Compounds; Oxadiazoles; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley | 2006 |
Nitric oxide inhibits mitochondrial movement in forebrain neurons associated with disruption of mitochondrial membrane potential.
Topics: Animals; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Hydrazines; Membrane Potentials; Mitochondria; Movement; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitrogen Oxides; Oxadiazoles; Prosencephalon; Quinoxalines; Rats; Time Factors | 2006 |
Platelet aggregation profile as a marker of hydroxyurea bioavailability through nitric oxide generation in chronic myelogenous leukemia.
Topics: Adult; Biological Availability; Blood Platelets; Cyclic GMP; Enzyme Inhibitors; Female; Humans; Hydroxyurea; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Nitric Oxide; Oxadiazoles; Platelet Aggregation; Quinoxalines; Time Factors | 2006 |
Nitric-oxide-dependent activation of pig oocytes: the role of the cGMP-signalling pathway.
Topics: Aminoquinolines; Animals; Cell Membrane Permeability; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Digitoxin; Dose-Response Relationship, Drug; Enzyme Activation; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase; Oocytes; Oxadiazoles; Penicillamine; Phosphoric Diester Hydrolases; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Swine | 2006 |
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury.
Topics: Animals; Blood Pressure; Cyclic GMP; Deuteroporphyrins; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Heart Rate; Heme Oxygenase-1; Liver; Mice; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Reperfusion Injury; Severity of Illness Index; Signal Transduction; Soluble Guanylyl Cyclase | 2006 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Glyburide; Indoles; KATP Channels; Male; Neurons; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Pertussis Toxin; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tolbutamide | 2006 |
Cardiac mitochondrial cGMP stimulates cytochrome c release.
Topics: Animals; Apoptosis; Cells, Cultured; Cyclic GMP; Cytochromes c; Guanosine Triphosphate; Guanylate Cyclase; Male; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Penicillamine; Quinoxalines; Rats; Rats, Wistar | 2007 |
Activation of the cGMP signaling pathway is essential in delaying oocyte aging in diabetes mellitus.
Topics: Animals; Cellular Senescence; Cyclic GMP; Cytoplasmic Granules; Diabetes Mellitus; Female; Mice; Microtubules; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oocytes; Oxadiazoles; Oxyhemoglobins; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction; Zona Pellucida | 2006 |
Nitric oxide preconditioning regulates endothelial monolayer integrity via the heat shock protein 90-soluble guanylate cyclase pathway.
Topics: Actin Cytoskeleton; Animals; Aorta; Apoptosis; Cattle; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Impedance; Endothelial Cells; Enzyme Inhibitors; Guanylate Cyclase; HSP90 Heat-Shock Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Spermine; Time Factors; Wound Healing | 2007 |
Activation of nitric oxide signaling pathway mediates hypotensive effect of Muntingia calabura L. (Tiliaceae) leaf extract.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Injections, Intravenous; Magnoliopsida; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Plant Extracts; Plant Leaves; Plants, Medicinal; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Tiliaceae; Water | 2006 |
Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent.
Topics: Adenosine; Adenosine Kinase; Animals; Cyclic GMP; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Hydrazines; Male; Nitric Oxide; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Thionucleotides; Xanthines | 2006 |
Nitric oxide directly inhibits ghrelin-activated neurons of the arcuate nucleus.
Topics: Action Potentials; Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; Calcium; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Ghrelin; Immunohistochemistry; Magnesium; Male; Neural Inhibition; Neurons; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptide Hormones; Quinoxalines; Rats; Rats, Wistar; Reaction Time; Thionucleotides | 2006 |
Heme oxygenase-1 mediates cytoprotection against nitric oxide-induced cytotoxicity via the cGMP pathway in human pulp cells.
Topics: Blotting, Western; Cell Survival; Cells, Cultured; Cyclic GMP; Cytoprotection; Dental Pulp; Enzyme Induction; Enzyme Inhibitors; Guanylate Cyclase; Heme Oxygenase-1; Hemin; Humans; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxidative Stress; Penicillamine; Protoporphyrins; Quinoxalines | 2006 |
CaM kinase II activation and phospholamban phosphorylation by SNP in murine gastric antrum smooth muscles.
Topics: Animals; Benzylamines; Calcium Signaling; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indoles; Mice; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Phosphorylation; Potassium Channel Blockers; Pyloric Antrum; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Soluble Guanylyl Cyclase; Sulfonamides | 2007 |
Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury.
Topics: Aerosols; Animals; Blotting, Western; Bronchi; Bronchoalveolar Lavage Fluid; Cyclic GMP; Enzyme Inhibitors; Epithelial Cells; Guanylate Cyclase; Immunohistochemistry; Inflammation; Inhalation; Lipopolysaccharides; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Oxadiazoles; Protein Subunits; Quinoxalines; Respiratory Distress Syndrome; RNA, Messenger; Solubility; Tumor Necrosis Factor-alpha | 2007 |
Involvement of the alpha4beta2 nicotinic receptor subtype in nicotine-induced attenuation of delta9-THC cerebellar ataxia: role of cerebellar nitric oxide.
Topics: Animals; Area Under Curve; Cerebellar Ataxia; Cerebellum; Chalcones; Cyclic GMP; Dronabinol; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Microinjections; Nicotine; Nicotinic Agonists; Nitric Oxide; Nitroprusside; Oxadiazoles; Postural Balance; Quinoxalines; Receptor, Cannabinoid, CB1; Receptors, Nicotinic; Stereotaxic Techniques | 2007 |
Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
Topics: Animals; Arginine; Cyclic GMP; Diaphragm; Drug Synergism; Electric Stimulation; Enzyme Activators; Exocytosis; Guanylate Cyclase; Indazoles; Intracellular Fluid; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Phrenic Nerve; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Sodium Nitrite; Xanthines | 2007 |
Intrathecal cGMP elicits pressor responses and maintains mean blood pressure during haemorrhage in anaesthetized rats.
Topics: Anesthesia; Animals; Arginine; Blood Pressure; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Heart Rate; Hemorrhage; Injections, Spinal; Nitric Oxide; Oxadiazoles; Pressoreceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Sympathetic Nervous System | 2007 |
Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Celecoxib; Coronary Vessels; Cyclic GMP; Endothelium, Vascular; Guanylate Cyclase; Guinea Pigs; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Perfusion; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Purinones; Pyrazoles; Quinoxalines; Rats; Regional Blood Flow; Signal Transduction; Sildenafil Citrate; Sulfonamides; Sulfones; Vasodilator Agents | 2007 |
YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activators; Gene Expression; Guanylate Cyclase; Indazoles; Lipopolysaccharides; Luciferases; Microglia; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Proline; Quinoxalines; Rats; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiocarbamates; Thionucleotides | 2007 |
Role of NO/cGMP/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice.
Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Piperazines; Potassium Channels; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones; Zymosan | 2007 |
Regulation of basolateral Cl(-) channels in airway epithelial cells: the role of nitric oxide.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amidines; Anions; Anthracenes; Benzylamines; Bestrophins; Cell Line; Cell Membrane; Cell Membrane Permeability; Cell Polarity; Chloride Channels; Cyclic GMP; Endothelial Cells; Epithelial Cells; Eye Proteins; Guanylate Cyclase; Humans; Ion Channel Gating; Lung; Macrophages, Alveolar; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; Respiratory Mucosa | 2006 |
Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: correlated with NO-cGMP signaling pathway.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiovascular Agents; Cell Proliferation; Cell Size; Cells, Cultured; Cyclic GMP; Fibroblasts; Intracellular Space; L-Lactate Dehydrogenase; Male; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Resveratrol; Signal Transduction; Stilbenes | 2007 |
Noradrenergic cell specific gene transfer with neuronal nitric oxide synthase reduces cardiac sympathetic neurotransmission in hypertensive rats.
Topics: Animals; Cyclic GMP; Enzyme Inhibitors; Gene Transfer Techniques; Heart; Heart Atria; Hypertension; Male; Myocardium; Neurons; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitroprusside; Norepinephrine; Oxadiazoles; Promoter Regions, Genetic; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Substrate Specificity; Sympathetic Nervous System; Synaptic Transmission | 2007 |
NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes.
Topics: Animals; Cells, Cultured; Chlorides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Flavonoids; Guanylate Cyclase; Membrane Potential, Mitochondrial; Microscopy, Confocal; Mitochondria, Heart; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxazines; Oxidation-Reduction; Penicillamine; Phosphorylation; Quinoxalines; Rats; Signal Transduction; Zinc; Zinc Compounds | 2007 |
Intracerebroventricular administration of nitric oxide-sensitive guanylyl cyclase inhibitors induces catalepsy in mice.
Topics: Animals; Arginine; Behavior, Animal; Catalepsy; Corpus Striatum; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Injections, Intraventricular; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Time Factors | 2007 |
Nitric oxide modulates ionic transport in the isolated intestine of the eel, Anguilla anguilla.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Anguilla; Animals; Arginine; Bicarbonates; Chlorides; Cyclic GMP; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Potentials; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Permeability; Quinoxalines; Time Factors | 2007 |
Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Female; Guanylate Cyclase; In Vitro Techniques; Indazoles; Isoenzymes; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Soluble Guanylyl Cyclase; Vasodilator Agents | 2007 |
Investigation of the vasorelaxant effects of 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) and diethylamine/nitric oxide (DEA/NO) on the human radial artery used as coronary bypass graft.
Topics: Aged; Analysis of Variance; Coronary Artery Bypass; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Hydrazines; In Vitro Techniques; Indazoles; Male; Middle Aged; Nitric Oxide Donors; Oxadiazoles; Peptides; Phenylephrine; Potassium Channels, Calcium-Activated; Quinoxalines; Radial Artery; Vasoconstrictor Agents; Vasodilation | 2007 |
Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway.
Topics: Animals; Aorta, Thoracic; Cell Proliferation; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Focal Adhesion Kinase 2; Guanylate Cyclase; Hypertrophy; Leucine; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Phosphorylation; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Soluble Guanylyl Cyclase | 2007 |
Inhibition of TGF-beta induced lung fibroblast to myofibroblast conversion by phosphodiesterase inhibiting drugs and activators of soluble guanylyl cyclase.
Topics: Actins; Benzamides; Benzoates; Blotting, Western; Cell Differentiation; Cells, Cultured; Cyclic GMP; Dinoprostone; Drug Synergism; Enzyme Activators; Fibroblasts; Fibrosis; Guanylate Cyclase; Humans; Immunohistochemistry; Isoenzymes; Lung; Myocytes, Smooth Muscle; Natriuretic Peptide, Brain; Nitric Oxide Donors; Nitroso Compounds; Oxadiazoles; Phosphodiesterase Inhibitors; Piperazines; Purines; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sildenafil Citrate; Soluble Guanylyl Cyclase; Sulfones; Transforming Growth Factor beta | 2007 |
Anxiolytic effects induced by inhibition of the nitric oxide-cGMP pathway in the rat dorsal hippocampus.
Topics: Analysis of Variance; Animals; Anxiety; Cyclic GMP; Dentate Gyrus; Dose-Response Relationship, Drug; Guanylate Cyclase; Hippocampus; Indazoles; Male; Maze Learning; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Punishment; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2007 |
Phosphodiesterase type 5 inhibition coupled to strong reinforcement results in two periods of transient retention loss in the young chick.
Topics: Analysis of Variance; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Chickens; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Discrimination, Psychological; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Memory Disorders; Phosphodiesterase 5 Inhibitors; Purinones; Quinoxalines; Reinforcement, Psychology; Retention, Psychology; Time Factors | 2007 |
Lipopolysaccharide induces early tolerance to excitotoxicity via nitric oxide and cGMP.
Topics: Animals; Anisomycin; Brain Diseases; Cyclic GMP; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Ischemic Preconditioning; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxadiazoles; Protein Synthesis Inhibitors; Quinoxalines | 2007 |
Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation.
Topics: Administration, Inhalation; Aerosols; Animals; Benzoates; Cyclic GMP; Dose-Response Relationship, Drug; Drug Combinations; Guanylate Cyclase; Injections, Intravenous; Lung; Morpholines; Nitric Oxide; Oxadiazoles; Particle Size; Phosphodiesterase Inhibitors; Powders; Pulmonary Circulation; Purinones; Pyrazoles; Pyridines; Pyrimidines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vasodilation | 2007 |
Nitric oxide signaling in the medial prefrontal cortex is involved in the biochemical and behavioral effects of phencyclidine.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cyclic GMP; Double-Blind Method; Electrodes, Implanted; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Mice; Microdialysis; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phencyclidine; Prefrontal Cortex; Quinoxalines; Radioimmunoassay; Reflex, Startle; Signal Transduction | 2008 |
Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis.
Topics: Animals; Colitis; Cyclic GMP; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Guanylate Cyclase; Inflammation; Male; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Soluble Guanylyl Cyclase | 2008 |
Involvement of accumulated NOS inhibitors and endothelin-1, enhanced arginase, and impaired DDAH activities in pulmonary dysfunction following subarachnoid hemorrhage in the rabbit.
Topics: Acetylcholine; Amidohydrolases; Animals; Arginase; Cyclic GMP; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin-1; Indomethacin; Lung Diseases; Male; Models, Biological; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vasoconstriction | 2008 |
Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.
Topics: Animals; Arginine; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Diazoxide; Disease Models, Animal; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Glutathione; Glyburide; Guanylate Cyclase; Hemoglobins; KATP Channels; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Peptic Ulcer Hemorrhage; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sildenafil Citrate; Stomach Ulcer; Sulfones | 2008 |
Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diazoxide; Dose-Response Relationship, Drug; Guanylate Cyclase; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Membrane Potentials; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Patch-Clamp Techniques; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Triazenes; Uncoupling Agents | 2008 |
Lysozyme, a mediator of sepsis that produces vasodilation by hydrogen peroxide signaling in an arterial preparation.
Topics: Aminoquinolines; Animals; Carotid Artery, Internal; Catalase; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Free Radical Scavengers; Guanylate Cyclase; Humans; Hydrogen Peroxide; Hydroquinones; In Vitro Techniques; Indomethacin; Mannitol; Mesenteric Artery, Superior; Methylene Blue; Muramidase; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Phenylephrine; Prostaglandins; Protein Kinase Inhibitors; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sepsis; Signal Transduction; Soluble Guanylyl Cyclase; Thionucleotides; Time Factors; Vasoconstrictor Agents; Vasodilation | 2008 |
Intrathecally injected morphine inhibits inflammatory paw edema: the involvement of nitric oxide and cyclic-guanosine monophosphate.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Enzyme Inhibitors; Guanylate Cyclase; Inflammation; Injections, Spinal; Male; Morphine; Naloxone; Narcotic Antagonists; Neutrophil Infiltration; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Oxadiazoles; Peroxidase; Phosphodiesterase Inhibitors; Piperazines; Purines; Quinoxalines; Rats; Rats, Wistar; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Sildenafil Citrate; Spinal Cord; Sulfones; Time Factors | 2008 |
Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation.
Topics: Adult; alpha-Thalassemia; Anemia, Sickle Cell; CD11a Antigen; CD11b Antigen; Cell Adhesion; Cyclic GMP; Endothelial Cells; Female; Fibronectins; Humans; Hydrazines; Hydroxyurea; Integrin alpha4; Intercellular Adhesion Molecule-1; Male; Middle Aged; Neutrophils; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sickle Cell Trait | 2008 |
Nitric oxide regulates steroid synthesis by bovine antral granulosa cells in a chemically defined medium.
Topics: Animals; Cattle; Cell Cycle; Cell Survival; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Female; Granulosa Cells; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Progesterone; Quinoxalines | 2009 |
NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Animals; Aqueous Humor; Cell Line; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Intraocular Pressure; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Microscopy, Confocal; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Osmolar Concentration; Oxadiazoles; Peptides; Perfusion; Potassium Channel Blockers; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Thionucleotides; Time Factors; Tissue Culture Techniques; Trabecular Meshwork | 2008 |
Two autocrine pathways to regulate cyclic GMP synthesis in cultured human retinal pigment epithelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Atrial Natriuretic Factor; Autocrine Communication; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Guanylate Cyclase; Humans; Immunohistochemistry; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Oxadiazoles; Phosphodiesterase Inhibitors; Pigment Epithelium of Eye; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Role of the soluble guanylyl cyclase alpha1/alpha2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus.
Topics: Animals; Carbon Monoxide; Cyclic GMP; Gastric Fundus; Guanylate Cyclase; Indazoles; Male; Mice; Mice, Knockout; Organometallic Compounds; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2008 |
Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SK(Ca) channels in NANC relaxation of mouse distal colon.
Topics: Animals; Apamin; Blotting, Western; Colon; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Female; Gastrointestinal Motility; Guanylate Cyclase; Male; Mice; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; Myenteric Plexus; Neural Inhibition; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Potassium Channel Blockers; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Small-Conductance Calcium-Activated Potassium Channels; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide | 2008 |
Interstitial cells of Cajal in the urethra are cGMP-mediated targets of nitrergic neurotransmission.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cyclic GMP; Enteric Nervous System; Enzyme Inhibitors; Female; Fluorescent Antibody Technique; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Synthase Type I; Nitroarginine; Oxadiazoles; Proto-Oncogene Proteins c-kit; Quinoxalines; Rats; Sheep; Synaptic Transmission; Ubiquitin Thiolesterase; Urethra; Vimentin | 2008 |
Calcitonin gene-related peptide suppresses pacemaker currents by nitric oxide/cGMP-dependent activation of ATP-sensitive K(+) channels in cultured interstitial cells of Cajal from the mouse small intestine.
Topics: Adenine; Animals; Calcitonin Gene-Related Peptide; Cells, Cultured; Cyclic GMP; Female; Guanylate Cyclase; Intestine, Small; KATP Channels; Male; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Quinoxalines | 2008 |
Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2.
Topics: Adenocarcinoma; Blotting, Western; Carcinoma, Large Cell; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cell Survival; Cyclic GMP; Enzyme Inhibitors; Fluorescent Antibody Technique; Grape Seed Extract; Guanylate Cyclase; Humans; Lung Neoplasms; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Plant Extracts; Proanthocyanidins; Quinoxalines; Receptors, Cell Surface; Signal Transduction; Tumor Cells, Cultured; Vitis | 2009 |
EGCG inhibits mammary cancer cell migration through inhibition of nitric oxide synthase and guanylate cyclase.
Topics: Animals; Anticarcinogenic Agents; Carcinoma; Catechin; Cell Line, Tumor; Cell Movement; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Mammary Neoplasms, Animal; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrogen Oxides; Oxadiazoles; Quinoxalines | 2008 |
Characterization of NO-sensitive guanylyl cyclase: expression in an identified interneuron involved in NO-cGMP-dependent memory formation.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Cyclic GMP; Electrophysiology; Enzyme Inhibitors; Guanylate Cyclase; Insect Proteins; Interneurons; Lymnaea; Memory; Molecular Sequence Data; Nitric Oxide; Oxadiazoles; Protein Subunits; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sequence Alignment; Soluble Guanylyl Cyclase | 2008 |
cGMP-independent anti-apoptotic effect of nitric oxide on thapsigargin-induced apoptosis in the pancreatic beta-cell line INS-1.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Line; Cyclic GMP; Dose-Response Relationship, Drug; Flow Cytometry; Insulin-Secreting Cells; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; Rats; Thapsigargin; Triazenes | 2008 |
Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Animals; Antibodies, Bacterial; Benzoates; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Female; Guanylate Cyclase; Imidazoles; Immunity, Cellular; Immunization; Immunoglobulin G; Interferon-gamma; Interleukin-4; Lipopolysaccharides; Lysine; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Oxadiazoles; Quinoxalines; S-Nitroso-N-Acetylpenicillamine; Skin Diseases, Bacterial; Spleen; Th1 Cells | 2009 |
Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cecum; Cyclic GMP; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Female; Guanylate Cyclase; Methylene Blue; Mortality; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; RNA, Messenger; Sepsis; Vasoconstriction | 2009 |
Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork.
Topics: Adult; Aged, 80 and over; Animals; Aqueous Humor; Blotting, Western; Cell Culture Techniques; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Humans; Isoenzymes; Organ Culture Techniques; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Swine; Trabecular Meshwork; Triazenes | 2009 |
PKG and PKA signaling in LTP at GABAergic synapses.
Topics: Animals; Animals, Newborn; Biophysics; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; In Vitro Techniques; Long-Term Potentiation; Mesencephalon; Models, Biological; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Synapses | 2009 |
Human trabecular meshwork cell volume decrease by NO-independent soluble guanylate cyclase activators YC-1 and BAY-58-2667 involves the BKCa ion channel.
Topics: Adult; Aged; Aged, 80 and over; Benzoates; Cell Size; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Guanylate Cyclase; Humans; Indazoles; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Confocal; Nitric Oxide; Oxadiazoles; Quinoxalines; Trabecular Meshwork | 2009 |
Epigallocatechin-3-gallate relaxes the isolated bovine ophthalmic artery: involvement of phosphoinositide 3-kinase-Akt-nitric oxide/cGMP signalling pathway.
Topics: Androstadienes; Animals; Catechin; Cattle; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanylate Cyclase; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Ophthalmic Artery; Oxadiazoles; Penicillamine; Peptides; Phosphatidylinositols; Proto-Oncogene Proteins c-akt; Quinoxalines; Serotonin; Signal Transduction; Vasodilation; Wortmannin | 2009 |
Redox variants of NO (NO{middle dot} and HNO) elicit vasorelaxation of resistance arteries via distinct mechanisms.
Topics: 4-Aminopyridine; Animals; Cyclic GMP; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Artery, Superior; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitrogen Oxides; Oxadiazoles; Oxidation-Reduction; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Vascular Resistance; Vasodilation; Vasodilator Agents | 2009 |
Evidence of a Ca(2+)-(*)NO-cGMP signaling pathway controlling zoospore biogenesis in the aquatic fungus Blastocladiella emersonii.
Topics: Amino Acid Sequence; Blastocladiella; Calcium; Cyclic GMP; Cytosol; Enzyme Activators; Enzyme Inhibitors; Expressed Sequence Tags; Fungal Proteins; Gene Expression Profiling; Guanylate Cyclase; Molecular Sequence Data; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Sequence Alignment; Signal Transduction; Spores, Fungal | 2009 |
Effects of chronic hypoxia on soluble guanylate cyclase activity in fetal and adult ovine cerebral arteries.
Topics: Altitude Sickness; Animals; Cerebral Arteries; Chronic Disease; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Endothelium-Dependent Relaxing Factors; Enzyme Inhibitors; Female; Fetus; Guanylate Cyclase; Hypoxia; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Pregnancy; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vasodilation | 2009 |
Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus.
Topics: Acetylcholine; Animals; Animals, Newborn; Benzoates; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fetus; Gestational Age; Guanylate Cyclase; Hypertension, Pulmonary; Muscle, Smooth, Vascular; Nitric Oxide; Oxadiazoles; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Pulmonary Wedge Pressure; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2009 |
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation.
Topics: Analysis of Variance; Animals; Back; CD47 Antigen; Cyclic GMP; Enzyme Inhibitors; Gene Silencing; Ischemia; Male; Mice; Mice, Inbred C57BL; Neovascularization, Physiologic; Nitric Oxide; Nitrites; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Surgical Flaps; Thrombospondin 1; Xanthine Dehydrogenase | 2009 |
Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia.
Topics: Analgesics; Animals; Arginine; Cyclic GMP; Down-Regulation; Female; Gonadal Hormones; Humans; Male; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Sex Characteristics; Signal Transduction; Temporomandibular Joint; Trigeminal Ganglion | 2009 |
Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia.
Topics: Animals; Apoptosis; Cell Death; Cell Line; Cell Membrane; Cell Nucleus; Cells, Cultured; Chromatin; Cyclic GMP; Enzyme Inhibitors; Intracellular Space; Mice; Mice, Inbred C57BL; Microglia; Neuroprotective Agents; Nitrites; Oxadiazoles; Phosphatidylserines; Quaternary Ammonium Compounds; Quinoxalines | 2009 |
Anxiolytic effects of phosphodiesterase-2 inhibitors associated with increased cGMP signaling.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Cells, Cultured; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Exonucleases; Guanylate Cyclase; Imidazoles; Male; Mice; Mice, Inbred ICR; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Oxadiazoles; Phosphodiesterase Inhibitors; Quinoxalines; Rats; Recombinant Proteins; Signal Transduction; Triazines | 2009 |
Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis.
Topics: Albumins; Animals; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Feedback, Physiological; Female; Glomerular Filtration Rate; Hydrostatic Pressure; Hypertension, Renal; Kidney; Natriuresis; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Renal Circulation; Urine | 2009 |
Nitric oxide inhibits platelet adhesion to collagen through cGMP-dependent and independent mechanisms: the potential role for S-nitrosylation.
Topics: Blood Platelets; Blood Proteins; Collagen; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanylate Cyclase; Humans; Immunoblotting; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Platelet Activation; Platelet Adhesiveness; Platelet Aggregation; Platelet Function Tests; Quinoxalines; S-Nitrosoglutathione; Signal Transduction | 2009 |
Complex interactions of NO/cGMP/PKG systems on Ca2+ signaling in afferent arteriolar vascular smooth muscle.
Topics: 1-Methyl-3-isobutylxanthine; ADP-ribosyl Cyclase; Animals; Arterioles; Calcium; Calcium Signaling; Carbazoles; Cyclic AMP; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Activators; Enzyme Inhibitors; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Peptides; Phosphodiesterase Inhibitors; Potassium Chloride; Quinoxalines; Rats; Rats, Sprague-Dawley | 2010 |
Nitric oxide stimulates interleukin-6 production in skeletal myotubes.
Topics: Animals; Cell Line; Cyclic GMP; Flavonoids; Imidazoles; Immunization; Interleukin-6; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 3; Muscle Fibers, Skeletal; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Pyrazoles; Pyridines; Quinoxalines; Up-Regulation | 2010 |
Protein kinase G type-Ialpha phosphorylates the apoptosis-regulating protein Bad at serine 155 and protects against apoptosis in N1E-115 cells.
Topics: Apoptosis; bcl-Associated Death Protein; Blotting, Western; Cell Line; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; DNA Fragmentation; Enzyme Activation; Humans; Nitric Oxide; Oxadiazoles; Phosphorylation; Quinoxalines; Recombinant Proteins; Serine | 2010 |
C-type natriuretic peptide regulation of guanosine-3',5'-cyclic monophosphate production in human endothelial cells.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Cyclic GMP; Endothelial Cells; Enzyme Inhibitors; Gene Expression; Guanylate Cyclase; Humans; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Nitric Oxide; Nitroprusside; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Quinoxalines; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Umbilical Cord | 2010 |
Propyretic role of the locus coeruleus nitric oxide pathway.
Topics: Animals; Cyclic GMP; Endotoxins; Fever; Guanylate Cyclase; Locus Coeruleus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2010 |
Cyclic GMP as a second messenger in the nitric oxide-mediated conidiation of the mycoparasite Coniothyrium minitans.
Topics: Arginine; Ascomycota; Cyclic AMP; Cyclic GMP; Guanylate Cyclase; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Second Messenger Systems; Spores, Fungal | 2010 |
Water extract of Zanthoxylum piperitum induces vascular relaxation via endothelium-dependent NO-cGMP signaling.
Topics: Androstadienes; Animals; Boron Compounds; Calcium; Calcium Channels; Cyclic GMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Gadolinium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxadiazoles; Plant Extracts; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thapsigargin; Vasoconstriction; Vasodilator Agents; Wortmannin; Zanthoxylum | 2010 |
Differential regulation of vasoactive intestinal peptide (VIP) in the dentate gyrus and hippocampus via the NO-cGMP pathway following kainic acid-induced seizure in the rat.
Topics: Animals; Cyclic GMP; Dentate Gyrus; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Guanylate Cyclase; Hippocampus; Indazoles; Kainic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Vasoactive Intestinal Peptide | 2010 |
Nitric oxide and downstream second messenger cGMP and cAMP enhance adipogenesis in primary human preadipocytes.
Topics: Adenylyl Cyclase Inhibitors; Adipocytes; Adipogenesis; Adult; Cell Proliferation; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic GMP; DDT; Guanylate Cyclase; Humans; Male; Middle Aged; Nitric Oxide; Oxadiazoles; Quinoxalines; Second Messenger Systems; Stem Cells; Subcutaneous Fat; Tissue Engineering | 2010 |
Nia1 and Nia2 are involved in exogenous salicylic acid-induced nitric oxide generation and stomatal closure in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cyclic ADP-Ribose; Cyclic GMP; Mutation; Niacinamide; Nitrate Reductase; Nitric Oxide; Nitroprusside; Oxadiazoles; Plant Stomata; Protein Kinase Inhibitors; Protein Kinases; Quinoxalines; Salicylic Acid; Signal Transduction | 2010 |
Increased degradation of MYPT1 contributes to the development of tolerance to nitric oxide in porcine pulmonary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Lung; Myosin-Light-Chain Phosphatase; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Protein Isoforms; Protein Phosphatase 1; Pulmonary Artery; Quinoxalines; Swine; Triazenes; Vasoconstrictor Agents | 2010 |
A soluble guanylate cyclase mediates negative signaling by ammonium on expression of nitrate reductase in Chlamydomonas.
Topics: Aminoquinolines; Arabidopsis; Arabidopsis Proteins; Calcium; Chlamydomonas reinhardtii; Cyclic GMP; Cyclic N-Oxides; Gene Expression Regulation, Enzymologic; Guanylate Cyclase; Imidazoles; Models, Biological; Molecular Sequence Data; Mutation; NG-Nitroarginine Methyl Ester; Nitrate Reductase; Nitric Oxide; Nitrogen; Oxadiazoles; Quaternary Ammonium Compounds; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase; Transcription, Genetic | 2010 |
Concomitant administration of nitric oxide and glucocorticoids improves protection against bronchoconstriction in a murine model of asthma.
Topics: Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Agents; Cyclic GMP; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Female; Glucocorticoids; Guanylate Cyclase; Hydrazines; Hydrocortisone; Injections, Intraperitoneal; Lipopolysaccharides; Methacholine Chloride; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Ovalbumin; Oxadiazoles; Pneumonia; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Respiration, Artificial; Respiratory Mechanics; Soluble Guanylyl Cyclase | 2010 |
Role of central NO-cGMP pathway in vasopressin and oxytocin gene expression during sepsis.
Topics: Animals; Arginine Vasopressin; Cyclic GMP; Enzyme Inhibitors; Gene Expression Regulation; Male; Nitric Oxide; Oxadiazoles; Oxytocin; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Wistar; Sepsis; Signal Transduction; Supraoptic Nucleus | 2010 |
Agonist-specific compartmentation of cGMP action in myometrium.
Topics: Animals; Blotting, Western; Caveolin 1; Cell Membrane; Cyclic GMP; Enzyme Inhibitors; Estrogens; Female; Glycolipids; Guanylate Cyclase; Guinea Pigs; Humans; Myometrium; Natriuretic Peptides; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pregnancy; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
Mechanisms of relaxant activity of the nitric oxide-independent soluble guanylyl cyclase stimulator BAY 41-2272 in rat tracheal smooth muscle.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Activation; Enzyme Activators; Guanylate Cyclase; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Trachea | 2010 |
Investigation of relaxant effects of new agents affecting nitric oxide/cyclic guanosine monophosphate pathway on sheep oddi sphincter.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Guanylate Cyclase; In Vitro Techniques; Male; Molsidomine; Muscle Relaxation; Muscle, Smooth; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Sheep; Sphincter of Oddi; Triazenes | 2010 |
Nitric oxide in the control of luminescence from lantern shark (Etmopterus spinax) photophores.
Topics: Animal Structures; Animals; Cyclic GMP; Embryo, Nonmammalian; Enzyme Inhibitors; Guanylate Cyclase; Hydroxylamine; Immunohistochemistry; Luminescence; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Sharks; Signal Transduction; Spectrum Analysis | 2010 |
Protective effects of YC-1 against glutamate induced PC12 cell apoptosis.
Topics: Animals; Apoptosis; Bisbenzimidazole; Cell Shape; Cell Survival; Cyclic GMP; Drug Synergism; Glutamates; Indazoles; Oxadiazoles; PC12 Cells; Protective Agents; Quinoxalines; Rats; Staining and Labeling | 2011 |
Role of the spinal cord NO/cGMP pathway in the control of arterial pressure and heart rate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Arginine; Blood Pressure; Cyclic GMP; Dimethyl Sulfoxide; Heart Rate; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stereoisomerism; Sympathetic Nervous System | 2011 |
Nitrergic inhibition of tachykininergic neuro-muscular transmission via cyclic GMP in the hamster ileum.
Topics: Animals; Cricetinae; Cyclic GMP; Ileum; Male; Membrane Potentials; Mesocricetus; Myocytes, Smooth Muscle; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Quinoxalines; Substance P; Tachykinins | 2011 |
Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.
Topics: Animals; ATP-Binding Cassette Transporters; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Calcitonin Receptor-Like Protein; Carbon Tetrachloride; Cyclic GMP; Electric Stimulation; Glyburide; KATP Channels; Liver Cirrhosis; Male; Mesenteric Arteries; Muscle Cells; Oxadiazoles; Peptide Fragments; Pinacidil; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Protein 1; Receptors, Calcitonin Gene-Related Peptide; Receptors, Drug; Sulfonylurea Receptors; Vasoconstriction; Vasodilation | 2011 |
Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia/reperfusion injury in the diabetic rat heart.
Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left | 2011 |
Neuroprotective mechanisms of minocycline against sphingomyelinase/ceramide toxicity: Roles of Bcl-2 and thioredoxin.
Topics: Animals; Blotting, Western; Carbazoles; Cells, Cultured; Ceramides; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Dinitrochlorobenzene; Genes, bcl-2; Minocycline; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sphingomyelin Phosphodiesterase; Thioredoxins | 2011 |
Phosphodiesterase 3A expression is modulated by nitric oxide in rat pulmonary artery smooth muscle cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Gene Expression; Guanylate Cyclase; Interleukin-1beta; Lysine; Myocytes, Smooth Muscle; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Pulmonary Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; S-Nitrosoglutathione; Soluble Guanylyl Cyclase; Tumor Necrosis Factor-alpha; Vasodilator Agents | 2010 |
Involvement of a NO-cyclic GMP-PKG signaling pathway in nitrous oxide-induced antinociception in mice.
Topics: Analgesics; Animals; Benzoates; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Glyburide; Imidazoles; Male; Mice; Naphthyridines; Nitric Oxide; Nitrous Oxide; Oxadiazoles; Pyrimidines; Quinoxalines; Signal Transduction; Thionucleotides | 2011 |
Modulating iNOS-uncoupling: a new therapeutic avenue to tackle reperfusion-injury?
Topics: Animals; Biopterins; Cyclic GMP; Diabetes Complications; Diabetes Mellitus, Experimental; Dithiothreitol; Imines; Male; Myocardial Reperfusion Injury; Nitric Oxide; Nitric Oxide Synthase Type II; Oxadiazoles; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Superoxides; Tiopronin; Tyrosine; Up-Regulation; Ventricular Function, Left | 2011 |
Essential roles of the nitric oxide (no)/cGMP/protein kinase G type-Iα (PKG-Iα) signaling pathway and the atrial natriuretic peptide (ANP)/cGMP/PKG-Iα autocrine loop in promoting proliferation and cell survival of OP9 bone marrow stromal cells.
Topics: Animals; Apoptosis; Atrial Natriuretic Factor; Autocrine Communication; Bone Marrow Cells; Cell Adhesion Molecules; Cell Line; Cell Proliferation; Cell Survival; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Microfilament Proteins; Multipotent Stem Cells; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphoproteins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Quinoxalines; RNA Interference; Signal Transduction | 2011 |
Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide.
Topics: Animals; Aorta; Cell Cycle Proteins; Cell Growth Processes; Cells, Cultured; Cyclic GMP; Cyclin D1; Endothelial Cells; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Natriuretic Peptide, C-Type; Oligopeptides; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Atrial Natriuretic Factor; Signal Transduction | 2011 |
Role of a novel tetrodotoxin-resistant sodium channel in the nitrergic relaxation of corpus cavernosum from the South American rattlesnake Crotalus durissus terrificus.
Topics: Acetylcholine; Animals; Callithrix; Carbolines; Crotalus; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitrergic Neurons; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Penis; Pyrazoles; Pyridines; Quinoxalines; Sodium Channel Blockers; Sodium Channels; Tadalafil; Tetrodotoxin; Vasodilator Agents | 2011 |
Tadalafil analgesia in experimental arthritis involves suppression of intra-articular TNF release.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthralgia; Arthritis, Experimental; Carbolines; Chemokine CXCL1; Chemokines; Cyclic GMP; Guanylate Cyclase; Injections, Intra-Articular; Interleukin-1; Joints; Male; Naloxone; Narcotic Antagonists; Neutrophils; Nociception; Osteoarthritis; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Tadalafil; Tumor Necrosis Factor-alpha; Zymosan | 2011 |
Intimal hyperplasia in balloon dilated coronary arteries is reduced by local delivery of the NO donor, SIN-1 via a cGMP-dependent pathway.
Topics: Actins; Analysis of Variance; Angioplasty, Balloon, Coronary; Animals; Coronary Angiography; Coronary Restenosis; Coronary Vessels; Cyclic GMP; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Guanylate Cyclase; Hyperplasia; Intermediate Filaments; Molsidomine; Myosins; NAD(P)H Dehydrogenase (Quinone); NADP; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Signal Transduction; Sus scrofa; Time Factors; Tunica Intima | 2011 |
The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.
Topics: Animals; Blotting, Western; Cell Line; Cyclic AMP; Cyclic GMP; Enzyme Activators; Enzyme Inhibitors; Glucose; Guanylate Cyclase; Indazoles; Insulin-Secreting Cells; Mitogen-Activated Protein Kinases; Morpholines; Oxadiazoles; Oxazines; Phosphoric Diester Hydrolases; Pyrimidines; Quinoxalines; Rats; Transcription, Genetic | 2011 |
Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test.
Topics: Animals; Antidepressive Agents; Arginine; Ascorbic Acid; Cyclic GMP; Depression; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Exploratory Behavior; Female; Hindlimb Suspension; Indazoles; Mice; N-Methylaspartate; Nitric Oxide; Oxadiazoles; Piperazines; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones | 2011 |
Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension.
Topics: Animals; Benzoates; Cells, Cultured; Cyclic GMP; Disease Models, Animal; Female; Fetus; Guanylate Cyclase; Humans; Hydrogen Peroxide; Infant, Newborn; Isoenzymes; Myocytes, Smooth Muscle; Nitric Oxide; Nitroprusside; Oxadiazoles; Persistent Fetal Circulation Syndrome; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Sheep; Soluble Guanylyl Cyclase; Vascular Resistance; Vasodilation; Vasodilator Agents | 2011 |
Activity of guanylyl cyclase activators on the reaction of tracheal smooth muscle contraction.
Topics: Animals; Carbachol; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activators; Enzyme Inhibitors; Female; Guanylate Cyclase; Indazoles; Male; Muscle, Smooth; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Trachea | 2011 |
The role of capillarisin from Artemisia capillaris on penile erection.
Topics: Animals; Artemisia; Chromones; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Drug Evaluation, Preclinical; Ethanol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Phenylephrine; Phosphodiesterase 5 Inhibitors; Plant Extracts; Quinoxalines; Rabbits; Radioimmunoassay; Signal Transduction | 2012 |
Inhibition of striatal soluble guanylyl cyclase-cGMP signaling reverses basal ganglia dysfunction and akinesia in experimental parkinsonism.
Topics: Animals; Basal Ganglia; Corpus Striatum; Cyclic GMP; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Mice, Inbred C57BL; Oxadiazoles; Parkinsonian Disorders; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Soluble Guanylyl Cyclase | 2011 |
2,3,4',5-tetrahydroxystilbene-2-O-β-D-glucoside inhibits proliferation of vascular smooth muscle cells: involvement of NO/cGMP/PKG pathway.
Topics: Animals; Becaplermin; Carbazoles; Cell Cycle; Cell Proliferation; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Glucosides; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Polygonum; Proto-Oncogene Proteins c-sis; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Stilbenes | 2012 |
Inhibition of neuronal nitric oxide synthase and soluble guanylate cyclase prevents depression-like behaviour in rats exposed to chronic unpredictable mild stress.
Topics: Animals; Antidepressive Agents; Cyclic GMP; Depression; Enzyme Inhibitors; Guanylate Cyclase; Hippocampus; Indazoles; Male; Nitric Oxide Synthase Type I; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Stress, Psychological; Swimming | 2012 |
Participation of the NO/cGMP/K+ATP pathway in the antinociception induced by Walker tumor bearing in rats.
Topics: Analgesics; Animals; Arginine; Carcinoma 256, Walker; Carrageenan; Cyclic GMP; Dinoprostone; Hyperalgesia; KATP Channels; Male; Nitric Oxide; Nociception; Oxadiazoles; Pain Measurement; Pain Threshold; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2012 |
Spermidine decreases Na⁺,K⁺-ATPase activity through NMDA receptor and protein kinase G activation in the hippocampus of rats.
Topics: Animals; Biguanides; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dizocilpine Maleate; Enzyme Activation; Hippocampus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Sodium-Potassium-Exchanging ATPase; Spermidine | 2012 |
Mechanism of relaxation and interaction with nitric oxide of the soluble guanylate cyclase stimulator BAY 41-2272 in mouse gastric fundus and colon.
Topics: Animals; Colon; Cyclic GMP; Enzyme Inhibitors; Gastric Fundus; Guanylate Cyclase; In Vitro Techniques; Isometric Contraction; Male; Mice; Mice, Inbred C57BL; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pyrazoles; Pyridines; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2012 |
Effect of nitric oxide on epithelial ion transports in noncystic fibrosis and cystic fibrosis human proximal and distal airways.
Topics: Adenosine Triphosphate; Adult; Aged; Amiloride; Bronchi; Chloride Channels; Colforsin; Cyclic GMP; Cyclic N-Oxides; Cystic Fibrosis; Epithelial Sodium Channel Blockers; Epithelial Sodium Channels; Free Radical Scavengers; Guanylate Cyclase; Humans; Imidazoles; Middle Aged; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Purinones; Quinoxalines; Young Adult | 2012 |
The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite.
Topics: Animals; Benzoates; Cyclic GMP; Guanidines; Guanylate Cyclase; Imidazoles; Isothiuronium; Larva; Metamorphosis, Biological; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Oxadiazoles; Quinoxalines; Signal Transduction; Thoracica | 2012 |
cGMP-dependent activation of protein kinase G precludes disulfide activation: implications for blood pressure control.
Topics: Animals; Aorta; Binding Sites; Blood Pressure; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Disulfides; Enzyme Activation; HEK293 Cells; Humans; Hydrogen Peroxide; Immunoblotting; In Vitro Techniques; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Oxidants; Oxidation-Reduction; Phosphorylation; Quinoxalines; Rats; Spermine; Vasodilation | 2012 |
In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet.
Topics: Animals; Blood Pressure; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Diet, Sodium-Restricted; Enzyme Inhibitors; Kidney; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Oxadiazoles; Prorenin Receptor; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Signal Transduction | 2012 |
Cinnamyl alcohol attenuates vasoconstriction by activation of K⁺ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dipeptides; Human Umbilical Vein Endothelial Cells; Humans; In Vitro Techniques; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Phenylephrine; Phosphorylation; Potassium Channel Blockers; Potassium Channels; Propanols; Quinoxalines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilation | 2012 |
Inducible NOS mediates CNP-induced relaxation of intestinal myofibroblasts.
Topics: Animals; Cyclic GMP; Guanylate Cyclase; Humans; Mice; Muscle Relaxation; Myofibroblasts; Natriuretic Peptide, C-Type; Nitric Oxide Synthase Type II; Nitroarginine; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2013 |
The lignan (-)-cubebin inhibits vascular contraction and induces relaxation via nitric oxide activation in isolated rat aorta.
Topics: Acetylcholine; Animals; Aorta; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; In Vitro Techniques; Indomethacin; Lignans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Piper; Quinoxalines; Rats; Rats, Wistar; Vasodilation | 2013 |
2-Aryl- and 2-amido-benzothiazoles as multifunctional vasodilators on rat artery preparations.
Topics: Animals; Arteries; Benzothiazoles; Calcium; Cyclic GMP; Extracellular Space; In Vitro Techniques; Intracellular Space; Male; Muscle Cells; Nitroprusside; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasoconstriction; Vasodilation; Vasodilator Agents | 2013 |
Cyclic guanosine monophosphate and the dependent protein kinase regulate lymphatic contractility in rat thoracic duct.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Guanylate Cyclase; Isoenzymes; Lymphatic Vessels; Male; Muscle Contraction; Nitric Oxide; Oxadiazoles; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Thoracic Duct | 2013 |
The role of aquaporin 1 activated by cGMP in myocardial edema caused by cardiopulmonary bypass in sheep.
Topics: Animals; Aquaporin 1; Cardiopulmonary Bypass; Cyclic GMP; Edema, Cardiac; Female; Myocytes, Cardiac; Oxadiazoles; Quinoxalines; Sheep, Domestic | 2013 |
Concentration-related effects of nitric oxide and endothelin-1 on human trabecular meshwork cell contractility.
Topics: Adult; Cell Physiological Phenomena; Cells, Cultured; Cyclic GMP; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Guanylate Cyclase; Humans; Infant; Middle Aged; Myosin Light Chains; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Phosphorylation; Quinoxalines; Tissue Donors; Trabecular Meshwork; Triazenes | 2014 |
The stimulating effects of nitric oxide on intermediate conductance Ca²⁺-activated K⁺ channels in human dermal fibroblasts through PKG pathways but not the PKA pathways.
Topics: 4-Aminopyridine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dermis; Enzyme Inhibitors; Fibroblasts; Humans; Intermediate-Conductance Calcium-Activated Potassium Channels; Nitric Oxide; Oxadiazoles; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Quinoxalines; Signal Transduction; Toxins, Biological; Wound Healing | 2014 |
Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenosine Triphosphate; Animals; Arachidonic Acid; Collagen; Cyclic GMP; Guanylate Cyclase; Humans; Iridoids; MAP Kinase Signaling System; Mice; Oxadiazoles; Phospholipase C gamma; Plant Extracts; Platelet Activation; Protein Kinase C; Quinoxalines; Thrombin; Thromboembolism; Thrombosis | 2014 |
The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats.
Topics: Animals; Arginine; Cyclic GMP; Enzyme Inhibitors; Glyburide; Guanidines; Guanylate Cyclase; KATP Channels; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitroarginine; Nociception; Ornithine; Oxadiazoles; Pain Measurement; Physical Conditioning, Animal; Quinoxalines; Rats; Signal Transduction | 2015 |
Nitric oxide augments single Ca(2+) channel currents via cGMP-dependent protein kinase in Kenyon cells isolated from the mushroom body of the cricket brain.
Topics: Action Potentials; Animals; Brain; Calcium Channels; Carbazoles; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Gryllidae; Male; Mushroom Bodies; Neurons; Nitric Oxide; Nitric Oxide Donors; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; Signal Transduction | 2015 |
Inhibition of PDE2A, but not PDE9A, modulates presynaptic short-term plasticity measured by paired-pulse facilitation in the CA1 region of the hippocampus.
Topics: Adenosine; Animals; CA1 Region, Hippocampal; Cadmium Chloride; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Long-Term Potentiation; Male; Morpholines; Neurons; Oxadiazoles; Presynaptic Terminals; Pyrimidines; Quinoxalines; Rats; Rats, Wistar | 2015 |
The soluble guanylate cyclase stimulator riociguat and the soluble guanylate cyclase activator cinaciguat exert no direct effects on contractility and relaxation of cardiac myocytes from normal rats.
Topics: Animals; Benzoates; Calcium; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Guanylate Cyclase; Isoproterenol; Muscle Relaxation; Myocardial Contraction; Myocytes, Cardiac; Oxadiazoles; Pyrazoles; Pyrimidines; Quinoxalines; Rats; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Thionucleotides; Verapamil | 2015 |
Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells.
Topics: Coculture Techniques; Coronary Vessels; Cyclic AMP; Cyclic GMP; Endothelial Cells; Humans; Indomethacin; Myocytes, Smooth Muscle; Nitroarginine; Oxadiazoles; Quinoxalines; Receptors, G-Protein-Coupled; Receptors, Peptide; Recombinant Proteins; Relaxin; Signal Transduction; Umbilical Arteries; Umbilical Veins | 2016 |
Cyclic GMP-mediated memory enhancement in the object recognition test by inhibitors of phosphodiesterase-2 in mice.
Topics: Animals; Carbazoles; Cell Adhesion Molecules; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Dose-Response Relationship, Drug; Guanylate Cyclase; Imidazoles; Male; Memory; Mice, Inbred ICR; Microfilament Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Phosphodiesterase Inhibitors; Phosphoproteins; Protein Kinase Inhibitors; Quinoxalines; Recognition, Psychology; Triazines | 2016 |
S-nitrosothiols dilate the mesenteric artery more potently than the femoral artery by a cGMP and L-type calcium channel-dependent mechanism.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cyclic GMP; Cysteine; Diltiazem; Female; Femoral Artery; Fetus; Indazoles; Male; Mesenteric Arteries; Nifedipine; Oxadiazoles; Quinoxalines; S-Nitrosoglutathione; S-Nitrosothiols; Sheep; Soluble Guanylyl Cyclase; Vasodilation; Vasodilator Agents | 2016 |
Nitric oxide in the insular cortex modulates baroreflex responses in a cGMP-independent pathway.
Topics: Animals; Baroreflex; Benzoates; Blood Pressure; Cerebral Cortex; Cyclic GMP; Enzyme Inhibitors; Heart Rate; Imidazoles; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2020 |
Nitric Oxide/Cyclic GMP-Dependent Calcium Signalling Mediates IL-6- and TNF-α-Induced Expression of Glial Fibrillary Acid Protein.
Topics: Animals; Astrocytes; Boron Compounds; Calcium Channel Blockers; Calcium Signaling; Cell Line, Tumor; Corpus Striatum; Cyclic GMP; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Humans; Imines; Interleukin-6; Male; Nitric Oxide; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Ryanodine; Tumor Necrosis Factor-alpha | 2021 |
Inhibition of endogenous ouabain by atrial natriuretic peptide is a guanylyl cyclase independent effect.
Topics: Adrenal Cortex; Atrial Natriuretic Factor; Cell Line, Tumor; Cyclic GMP; Guanylate Cyclase; Humans; Ouabain; Oxadiazoles; Peptide Fragments; Quinoxalines; Radioimmunoassay; Receptors, Atrial Natriuretic Factor; Receptors, Cell Surface; Second Messenger Systems; Vasodilator Agents | 2021 |