quinoxalines has been researched along with brimonidine tartrate in 1241 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 135 (10.88) | 18.7374 |
| 1990's | 452 (36.42) | 18.2507 |
| 2000's | 462 (37.23) | 29.6817 |
| 2010's | 177 (14.26) | 24.3611 |
| 2020's | 15 (1.21) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, Z; Matsubara, T; Moskowitz, MA | 1 |
| Baird, M; Daly, CJ; Gordon, JF; McGrath, JC | 1 |
| Dauzats, M; Lafontan, M; Langin, D; Portillo, M | 1 |
| Honda, K; Kaneko, M; Kanno, T; Kumashiro, H; Mashiko, H; Oosuga, N; Watanabe, A | 1 |
| Slavik, KJ; Szilagyi, JE | 2 |
| Paris, H; Remaury, A | 1 |
| Carr, IC; Jess, T; MacNulty, EE; McClue, SJ; Milligan, G; Wakelam, MJ | 1 |
| Buchholz, J; Duckles, SP; Friedman, D; Tsai, H | 1 |
| Gnegy, ME; Mangels, LA | 1 |
| Bourne, HR; Conklin, BR; Wong, YH | 1 |
| Hao, Q; Hauth, T; Hyman, A; Lippton, HL | 1 |
| Atkinson, BN; Minneman, KP | 1 |
| Dieudonne, MN; Giudicelli, Y; Pecquery, R | 2 |
| Coupry, I; Downing, S; Duzic, E; Lanier, SM | 1 |
| Coupry, I; Duzic, E; Lanier, SM | 1 |
| Barturen, F; García-Sevilla, JA; Meana, JJ | 2 |
| Barturen, F; Gabilondo, AM; García-Sevilla, JA; Meana, JJ | 1 |
| Goldstein, M; Masuyama, Y; Nishio, I; Tsuda, K; Tsuda, S | 1 |
| Franco-Cereceda, A; Lou, YP; Lundberg, JM | 1 |
| Blandford, DE; Li, P; Penner, SB; Smyth, DD | 1 |
| Cawthorne, MA; Kelly, J; Roberts, SP; Sennitt, MV | 1 |
| Okuma, Y; Reisine, T | 1 |
| Akbarali, H; Horstman, DA; Limbird, LE; Surprenant, A | 1 |
| Berridge, TL; Doxey, JC; Roach, AG; Smith, CF | 1 |
| Jansen van't Land, C; van der Laan, JW | 1 |
| García-Sevilla, JA; Grijalba, B; Pascual, J; Pazos, A; Zarranz, JJ | 1 |
| Limberger, N; Starke, K; Trendelenburg, AU | 6 |
| Lefebvre, RA; Smits, GJ | 1 |
| Duzic, E; Lanier, SM | 1 |
| Cynader, MS; Matsuo, T | 1 |
| Bovier, P; Gaillard, JM; Karege, F; Tissot, R; Widmer, J | 1 |
| Commissaris, RL; Fontana, DJ | 1 |
| Crosson, CE; DeVries, GW; Heath, AR; Potter, DE | 1 |
| Biegon, A; Budinger, TF; Mathis, CA | 1 |
| Bourreau, JP; Daniel, EE; Kwan, CY; Shimamoto, H | 1 |
| Barturen, F; Fontán, A; García-Sevilla, JA; Garro, MA; Meana, JJ; Zarranz, JJ | 1 |
| Evans, BK; Mason, R; Wilson, VG | 1 |
| Beauville, M; Crampes, F; Garrigues, M; Harant, I; Riviere, D; Tauber, JP; Tauber, MT | 1 |
| Nagao, T; Vanhoutte, PM | 1 |
| McClue, SJ; Milligan, G | 1 |
| Guimarães, JT; Guimarães, S; Moura, D; Nunes, JP; Vaz-da-Silva, MJ | 1 |
| Minneman, KP; Wilson, KM | 1 |
| Ball, SG; Ong, ML; Vaughan, PF | 1 |
| McKenzie, FR; Milligan, G | 1 |
| Agneter, E; Drobny, H; Singer, EA | 1 |
| Fitzgerald, RD; Harris, GC | 1 |
| Arthaud, A; Berdeaux, A; Giudicelli, JF; Lambert, C | 1 |
| Halliday, CA; Jones, BJ; Skingle, M; Tyers, MB; Walsh, DM; Wise, H | 1 |
| Daviaud, D; Denis-Pouxviel, C; Devedjian, JC; Fargues, M; Paris, H; Prats, H | 1 |
| Elliott, JM; Glue, P; Kay, G; Nutt, DJ; Payvandi, N | 1 |
| Mittag, TW; Podos, SM; Serle, JB; Steidl, S; Wang, RF | 1 |
| Rand, MJ; Xiao, XH | 3 |
| Andersson, RG; Grundström, N; Jacobsson, L | 1 |
| Dunn, WR; McGrath, JC; Wilson, VG | 2 |
| MacNulty, EE; McClue, SJ; Milligan, G; Wakelam, MJ | 1 |
| Ruff, G; Rump, LC; Schollmeyer, P; Wolk, V | 1 |
| Blackburn, TP; Chapman, H; Demarinis, RM; Edwards, R; Hieble, JP; Roberts, SP; Shah, DH; Sulpizio, AC; Wood, MD; Young, P | 1 |
| Bültmann, R; Starke, K; von Kügelgen, I | 1 |
| Schwietert, HR; van Zwieten, PA; Wilffert, B; Wilhelm, D | 1 |
| Boehm, S; Huck, S | 4 |
| Gleason, MM; Hieble, JP | 1 |
| Healy, D; Horton, RW; Kerry, SM; Lawrence, KM; Paykel, ES; Theodorou, AE; White, W; Whitehouse, AM; Wilton-Cox, H | 1 |
| Böhm, S; Drobny, H; Huck, S; Singer, EA | 1 |
| Arnsten, AF; Leslie, FM | 1 |
| Barnes, PJ; Crawley, DE; Evans, TW; Liu, SF | 1 |
| Benishin, C; Fredholm, BB; Hu, PS | 1 |
| del Arco, C; del Olmo, E; Díaz, A; González, AM; Pascual, J; Pazos, A | 1 |
| Bidet, M; Parini, A; Poujeol, P | 2 |
| Conway, S; Krulich, L; Mauceri, H; Moherek, R; Richardson, L; Speciale, S | 1 |
| Lepor, H | 1 |
| Osborne, NN | 1 |
| Bauer, BA; Bove, AA; Brum, JM; Miller, TD; Rogers, PJ; Vanhoutte, PM | 1 |
| Carr, C; Gould, GW; Lavan, BE; Milligan, G; Mullaney, I | 1 |
| Flavahan, NA; Miller, VM; Vanhoutte, PM | 1 |
| Gelbmann, CM; Müller, WE | 1 |
| Areso, P; García-Sevilla, JA; Giralt, MT; Guimón, J; Padró, D | 1 |
| Illes, P; Regenold, JT | 1 |
| Abe, K; Matsuki, N; Saito, H | 1 |
| Carrasco, VN; Faber, JE; Pillsbury, HC; Prazma, J; Triana, RJ | 1 |
| Flavahan, NA; Komori, K; Miller, VM; Vanhoutte, PM | 1 |
| Atgie, C; Carpene, C; Lafontan, M; Quideau, N; Saulnier-Blache, JS | 1 |
| Lafontan, M; Langin, D; Paris, H | 1 |
| Dauzats, M; Lafontan, M; Langin, D; Paris, H | 1 |
| Hayashi, S; Ishima, T; Kano, S; Kimura, K; Matsuzaki, T; Miura, A; Ukai, Y | 1 |
| Carpéné, C; Galitzky, J; Lafontan, M; Saulnier-Blache, JS | 1 |
| Barbe, P; Berlan, M; Estan, L; Guimbaud, R; Louvet, JP; Montastruc, JL; Senard, JM; Tran, MA | 1 |
| Carpéné, C; Galitzky, J; Lafontan, M; Langin, D; Larrouy, D | 1 |
| Carpéné, C; Dauzats, M; Lafontan, M; Larrouy, D; Quideau, N; Saulnier-Blache, JS | 1 |
| Angel, I; Langer, SZ; Niddam, R | 1 |
| Angel, I; Bidet, S; Langer, SZ; Niddam, R | 1 |
| Doxey, JC; John, GW; Reid, JL; Walter, DS | 2 |
| Berlan, M; Galitzky, J; Lafontan, M; Montastruc, JL; Senard, JM; Stillings, M | 1 |
| Agneter, E; Cejna, M; Drobny, H; Singer, EA; Valenta, B | 1 |
| Bylund, DB; Creighton, JA; Paredez, S; Petterborg, LJ; Rudeen, PK | 1 |
| Alari, L; Axelsson, KL; Persson, ML; Post, C; Uhlén, S; Wikberg, JE | 1 |
| Akasu, T; Tokimasa, T; Tsurusaki, M | 1 |
| Guimaraes, S; Nunes, JP | 2 |
| Eikenburg, DC | 1 |
| Altemeyer, KH; Dirks, B; Ensinger, H; Grünert, A | 1 |
| Boulanger, C; Flavahan, NA; Katusic, ZS; Komori, K; Vanhoutte, PM; Vos, AA | 1 |
| Calvo, P; del Arco, C; Fernández-López, A; Gómez, T; González, AM; Pazos, A | 1 |
| Chien, DS; Gluchowski, C; Homsy, JJ; Tang-Liu, DD | 1 |
| Kilfeather, S; O'Malley, K; Stein, M | 1 |
| Dettmar, PW; Downing, OA; Roach, AG; Urquhart, CJ; Williams, RJ; Wilson, KA | 1 |
| Guimarães, S; Moura, D; Vaz-da-Silva, MJ | 1 |
| Blier, P; Galzin, AM; Langer, SZ | 1 |
| Bylund, DB; Jones, SB; Leone, SL | 1 |
| Carpéné, C; Guichard, C; Lafontan, M; Lavau, M; Rebourcet, MC | 1 |
| Allen, RM; Kunkel, SL; Remick, DG; Spengler, RN; Strieter, RM | 1 |
| Brandon, S; Cragoe, EJ; Guyer, CA; Horstman, DA; Limbird, LE; Wilson, AL | 1 |
| Crosson, CE; Heath, AR; Ogidigben, MJ; Potter, DE | 1 |
| MacLean, MR; McGrath, JC | 1 |
| Doussau, MP; Gautier, P; Giudicelli, JF; Mulder, P; Richer, C | 1 |
| Calvete, J; Hayes, R; Sever, PS; Thom, S | 1 |
| Armstead, WM; Hyman, AL; Kadowitz, PJ; Lippton, HL | 1 |
| Giudicelli, Y; Leneveu, MC; Pecquery, R | 1 |
| Hill, SJ; Straw, RM | 1 |
| Giudicelli, JF; Richer, C; Scalbert, E | 1 |
| Goldstein, M; Tsuda, K; Yokoo, H | 1 |
| Pratt, BL; Takahashi, JS | 1 |
| Baumann, M; Gup, DI; Lepor, H; Shapiro, E | 1 |
| Galzin, AM; Langer, SZ; Ramdine, R | 1 |
| Flavahan, NA; Shimokawa, H; Vanhoutte, PM | 2 |
| Lacroix, JS; Lundberg, JM | 1 |
| Uhlén, S; Wikberg, JE | 2 |
| Alden, BM; Matherne, GP; Nakamura, KT; Robillard, JE; Rusch, NJ | 1 |
| Lundberg, JM; Martling, CR; Matran, R | 1 |
| Hughes, AD; Martin, GN; Mulvany, MJ; Nielsen, H; Sever, PS; Thom, SM | 1 |
| Angel, I; Taranger, MA | 1 |
| Bylund, DB; Ray-Prenger, C | 1 |
| García-Sáinz, JA; Martínez, OM | 1 |
| Bill, DJ; Hughes, IE; Stephens, RJ | 1 |
| Galitzky, J; Paris, H; Senard, JM | 1 |
| Albuquerque, AA; Goncalves, J; Paiva, MQ; Proenca, J | 1 |
| Christie, MJ; Miyake, M; North, RA | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Mauriege, P | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Paris, H | 1 |
| Fredholm, BB; Hu, PS | 2 |
| Goldberg, LI; Kohli, JD; Metra, M; Satoh, Y | 1 |
| Ashton, J; Brown, CG; Hamlin, RL; Jenkins, J; Van Ligten, P; Werman, HA | 1 |
| Cattaneo, AG; Doxey, JC; Efendic, S; Ostenson, CG | 1 |
| Lapetina, EG; Siess, W | 1 |
| Bobker, DH; Shen, KZ; Surprenant, A; Williams, JT | 1 |
| Jurcovicová, J; Krulich, L; Le, T | 1 |
| Carpéné, C; Lafontan, M; Langin, D; Saulnier-Blache, JS | 1 |
| Burke, J; Crosson, C; Potter, D | 1 |
| Berlan, M; Lafontan, M; Montastruc, P; Taouis, M | 1 |
| Hashimoto, K; Tsujimoto, G | 1 |
| Edwards, RM; Trizna, W | 1 |
| Areso, P; García-Sevilla, JA; Giralt, MT; Ulibarri, I | 1 |
| Harker, CT; Vanhoutte, PM | 1 |
| Gantzos, RD; Neubig, RR; Thomsen, WJ | 1 |
| Gantzos, RD; Neubig, RR | 1 |
| Hinton, CF; White, JF | 1 |
| Downing, OA; Stein, W; Wilson, KA; Wilson, VG | 1 |
| Barturen, F; García-Sevilla, JA; González, AM; Meana, JJ; Pascual, J; Pazos, A | 1 |
| Akasu, T; Nishimura, T; Tokimasa, T; Tsurusaki, M | 1 |
| Daly, CJ; McGrath, JC; Wilson, VG | 2 |
| Feder, HH; Vincent, PA | 1 |
| Calvete, J; Hayes, R; Martin, G; Sever, P; Thom, S | 1 |
| Doxey, JC; Roach, AG; Samuel, J | 1 |
| Guimarães, S; Paiva, MQ; Polónia, JJ | 1 |
| Honda, K; Miyata-Osawa, A; Shiono, K; Takenaka, T; Terai, M | 1 |
| Hesse, IF; Johns, EJ | 1 |
| Horng, JS; Messick, K; Ruffolo, RR | 1 |
| Lattimer, N; Rhodes, KF | 1 |
| Hyman, AL; Kadowitz, PJ | 2 |
| Bylund, DB; Ray-Prenger, C; Turner, JT | 1 |
| Brasier, RS; Gantzos, RD; Neubig, RR | 1 |
| Hicks, PE; Waldron, CJ | 1 |
| Greenwood, B; Read, NW | 1 |
| Berridge, TL; Roach, AG | 1 |
| Dickinson, KE; McKernan, RM; Miles, CM; Sever, PS | 1 |
| Burke, JA; Potter, DE | 1 |
| Bassenge, E; Elsner, D; Holtz, J; Sommer, O; Stewart, DJ | 1 |
| Dettmar, PW; Lord, JA | 1 |
| Berlan, M; Lafontan, M; Taouis, M | 1 |
| Bond, RA; Charlton, KG; Clarke, DE | 1 |
| Bylund, DB; Jones, SB; Toews, ML; Turner, JT | 1 |
| Gesek, FA; Strandhoy, JW; Wolff, DW | 1 |
| Itoh, H; Kohli, JD; Rajfer, SI | 1 |
| Broadley, KJ; Williamson, KL | 1 |
| Duman, RS; Enna, SJ; Nomura, S | 1 |
| Rhodes, KF; Waterfall, JF | 1 |
| Convents, A; Convents, D; De Backer, JP; Vauquelin, G | 1 |
| Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Palm, D; Schloos, J; Wellstein, A | 1 |
| Crist, J; Surprenant, A | 1 |
| Hollier, LH; Miller, VM; Reigel, MM; Vanhoutte, PM | 1 |
| Goldstein, M; Schlesinger, DH; Yokoo, H | 1 |
| Armstead, WM; Hyman, AL; Kadowitz, PJ; Lippton, HL; Roland, PY | 1 |
| Bylund, DB; Murphy, TJ | 1 |
| Graham, RM; Powell, WJ; Supple, EW | 1 |
| Bylund, DB; Petterborg, LJ; Ray-Prenger, C; Rudeen, PK | 1 |
| Nyman, L; Saano, V; Savola, JM; Virtanen, R | 1 |
| North, RA; Surprenant, A | 1 |
| Angel, I; Bidet, S; Langer, SZ | 1 |
| Carpéné, C; Lavau, M; Rebourcet, MC | 1 |
| Hieble, JP; Nichols, AJ; Ruffolo, RR; Sulpizio, AC; Willette, RN | 1 |
| Gonçalves, J; Guimarães, S; Nunes, JP; Paiva, MQ | 1 |
| Andorn, AC; Carlson, MA; Gilkeson, RC | 1 |
| Jacquez, JA; Neubig, RR; Thomsen, WJ | 1 |
| Angel, I; Langer, SZ | 1 |
| Faber, JE; Gettes, DR; Gianturco, DP | 1 |
| Hair, WM; Hughes, AD; Martin, GN; Nielsen, H; Schachter, M; Sever, PS; Thom, SA | 1 |
| Messick, K; Ruffolo, RR | 1 |
| Miller, VM; Vanhoutte, PM | 1 |
| Flavahan, NA; Vanhoutte, PM | 3 |
| Hyman, AL; Kadowitz, PJ; Lippton, HL | 1 |
| Pipili, E | 1 |
| Davies, SL; Hale, AS; Horton, RW; Katona, CL; Kelly, JS; Paykel, ES; Theodorou, AE; Yamaguchi, Y | 1 |
| Duman, RS; Enna, SJ | 1 |
| Kassarich, J; Lien, EL; Morrison, A; Sullivan, D | 1 |
| Flavahan, NA; Gisclard, V; Vanhoutte, PM | 1 |
| Adler, CH; Goldstein, M; Meller, E | 1 |
| Aarhus, LL; Flavahan, NA; Miller, VM; Vanhoutte, PM | 1 |
| Bullock, GR; Taylor, SG; Weston, AH | 1 |
| Denis, C; Murat, JC; Paris, H | 1 |
| Fähndrich, E; Haug, HJ; Rommelspacher, H; Strauss, S | 1 |
| Davies, SL; Horton, RW; Mistry, H; Theodorou, AE; Yamaguchi, Y | 1 |
| Howard, MJ; Insel, PA; McKernan, RM; Motulsky, HJ | 1 |
| Brandon, S; Cragoe, EJ; Limbird, LE; Nunnari, JM; Repaske, MG | 1 |
| Fernandez-Roman, M; Fuentes, JA; Naranjo, JR; Urdin, MC | 1 |
| Dooley, DJ; Hertting, G; Lupp, A; Osswald, H | 1 |
| Armstrong, JM; Atkinson, J; Boillat, N; de Rivaz, JC; Fluckiger, JP; Fouda, AK; Piton, MC; Porchet, PA; Sautel, M; Sonnay, M | 1 |
| Appleton, CP; Goldman, S; Lee, RW; Martin, GV; Olajos, M | 1 |
| Cambridge, D | 1 |
| Cavero, I; Gomeni, R; Lefèvre-Borg, F; Roach, AG; Scatton, B | 1 |
| Nelson, WL; Ruffolo, RR; Yaden, EL | 1 |
| Cavero, I; Doxey, JC; Roach, AG; Strachan, DA | 1 |
| Kerry, R; Scrutton, MC | 1 |
| Bradshaw, CM; Sheridan, RD; Szabadi, E | 1 |
| Loftus, DJ; Stolk, JM; U'Prichard, DC | 1 |
| Shepperson, NB | 1 |
| Bogaert, MG; Lefebvre, RA; Verplanken, PA | 1 |
| Beckeringh, JJ; De Jonge, A; Thoolen, MJ; Timmermans, PB; Van Zwieten, PA; Wilffert, B | 1 |
| Hicks, PE | 1 |
| Doussau, MP; Giudicelli, JF; Richer, C | 1 |
| McWilliam, JR; Meldrum, BS | 1 |
| Angel, I; Coste, A; Guillot, E | 1 |
| Funk, L; Limberger, N; Starke, K; Trendelenburg, AU | 1 |
| Chou, B; Green, PG; Khasar, SG; Levine, JD | 1 |
| Berggren, H; McGregor, CG; Miller, VM; Nilsson, F; Sjöquist, PO; Wiklund, L | 1 |
| Camras, CB; Gleason, ML; Toris, CB; Yablonski, ME | 1 |
| Starke, K; Szabo, B; Urban, R | 3 |
| Fernández-López, A; Pazos, A | 1 |
| Anderson, NG; Milligan, G | 1 |
| Agneter, E; Boehm, S; Drobny, H; Huck, S; Koth, G; Singer, EA | 1 |
| Lester, BR; Sun, Z; Wilcox, GL; Wu, HH | 1 |
| Boeckxstaens, GE; De Man, JG; Herman, AG; Pelckmans, PA | 1 |
| Cambria, RA; Gloviczki, P; Lowell, RC; Miller, VM | 1 |
| Barajas-López, C | 1 |
| Advenier, C; Biyah, K | 1 |
| Kemmotsu, O; Matsumoto, M; Numazawa, R; Saito, H; Togashi, H; Yoshioka, M | 1 |
| Bryan, RM; Eichler, MY; Johnson, TD; Steenberg, ML; Suresh, MS; Swafford, MW | 1 |
| Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG | 1 |
| Acheampong, AA; Shackleton, M; Tang-Liu, DD | 1 |
| Dalley, JW; Stanford, SC | 1 |
| Bouloumie, A; Galitzky, J; Lafontan, M; Langin, D; Remaury, A; Tavernier, G; Valet, P | 1 |
| Agneter, E; Boehm, S; Drobny, H; Huck, S; Schwarz, K; Singer, EA | 1 |
| Dyamenahalli, U; Haworth, SG; Stuart-Smith, K; Tulloh, RM | 1 |
| Deth, RC; Jinsi, A | 1 |
| Aburto, T; Deth, RC; Jinsi, A; Zhu, Q | 1 |
| Hara, M; Inoue, M; Irie, T; Mikami, T; Mikami, Y; Minato, A; Omori, K; Uyama, M; Yasukura, T; Zeng, XT | 1 |
| de Villiers, AS; Jaffer, A; Russell, VA; Sagvolden, T; Searson, A; Taljaard, JJ | 1 |
| Després, JP; Lemieux, S; Mauriège, P; Prud'homme, D; Tremblay, A | 1 |
| Grudt, TJ; Travagli, RA; Williams, JT | 1 |
| Szabo, B; Urban, R | 1 |
| Burke, J; Kharlamb, A; Manlapaz, C; Padillo, E; Runde, E; Shan, T; Wheeler, L | 1 |
| Galligan, JJ | 1 |
| Connor, HE; O'Shaughnessy, CT; Waldron, GJ | 1 |
| Angel, I; Eon, MT; Langer, SZ; Lorrain, J; Oblin, A | 1 |
| Butler, A; Connor, HE; O'Shaughnessy, CT; Worton, SP | 1 |
| Imura, H; Shimatsu, A; Tanoh, T; Tsuji, I; Yanaihara, N | 1 |
| Debink, N; Gabelt, BT; Hubbard, WC; Kaufman, PL; Peterson, CM; Robinson, JC; Wadhwa, A | 1 |
| Gasic, S; Green, A | 1 |
| Bohmann, C; Rump, LC; Schaible, U; Schollmeyer, P | 1 |
| Dobbs, LG; Pian, MS | 1 |
| Birnbaum, AK; Law, PY; Wilcox, GL; Wotta, DR | 1 |
| Albino-Teixeira, A; Guimarães, S; Moura, D; Paiva, MQ; Vaz-da-Silva, MJ | 1 |
| Ge, YZ; Morrison, SF | 1 |
| Hanmer, C; Kendall, DA; Mason, R; Millns, P; Pinthong, D; Wilson, VG; Wright, IK | 1 |
| Abel, PW; Balasubramaniam, A; Conlon, JM; Porter, JE | 1 |
| Cable, HC; el-Mansoury, A; Morgan, NG | 1 |
| Gazzola, C; Hunter, RA; Lisle, AT; Magner, T | 1 |
| Duckles, SP; Friedman, DJ | 1 |
| Cai, JJ; Lee, HC; Martins, JB; Samson, RA; Shibata, EF | 1 |
| Berlan, M; Bousquet-Mélou, A; Galitzky, J; Lafontan, M | 1 |
| Dingus, J; Hildebrandt, JD; Kataoka, R; Lanier, SM; Sato, M; Wilcox, M | 1 |
| Serle, JB | 2 |
| Allgaier, C; Belledin, M; Hertting, G; Jackisch, R; Schobert, A | 1 |
| Chen, KS; Nordlund, JR; Ordman, J; Pasquale, LR; Robin, AL; Rudikoff, MT; Walt, J | 1 |
| Guyenet, PG; Li, YW | 1 |
| Regunathan, S; Reis, DJ | 1 |
| Andersson, RG; Grundström, N; Johansson-Rydberg, IG | 1 |
| Anciones, B; Berciano, J; Grijalba, B; Pascual, J; Pazos, A | 1 |
| Boehm, S | 1 |
| Dolezal, V; Heldt, R; Hertting, G; Schobert, A | 1 |
| Arner, P; Hoffstedt, J; Lönnqvist, F; Nilsell, K; Thöme, A | 1 |
| Grassie, MA; Milligan, G | 1 |
| Boulanger, CM; Kirchengast, M; Lee, JJ; Park, SJ; Vanhoutte, PM | 1 |
| Guo, HY; Lorenz, RR; Vanhoutte, PM | 1 |
| García-Sevilla, JA; Garro, MA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| Qü, M; Schleicher, A; Zilles, K | 1 |
| Dodds, WJ; Lang, IM; Sarna, SK | 1 |
| Ferrell, WR; Najafipour, H | 1 |
| Driessen, B; Starke, K; von Kügelgen, I | 1 |
| Robinson, NE; Wang, Z; Yu, M | 1 |
| Faber, JE; Ikeoka, K | 1 |
| Musgrave, IF; Seifert, R | 1 |
| Feder, HH; Malik, KF; Morrell, JI | 1 |
| Bourne, HR; Brandon, S; Chabre, O; Conklin, BR; Limbird, LE | 1 |
| Limberger, N; Starke, K; Trendelenburg, AU; Trendelenburg, M | 1 |
| Kurose, H; Lefkowitz, RJ | 1 |
| Etgen, AM; Karkanias, GB | 1 |
| Barturen, F; del Arco, C; García-Sevilla, JA; González, AM; Meana, JJ; Pascual, J; Pazos, A | 1 |
| García-Sevilla, JA; Sastre, M | 1 |
| Limberger, N; Rump, LC; Trendelenburg, AU | 1 |
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| Cassel, JC; Ferry, B; Lazarus, C; Marien, M; McGaugh, JL; Parrot, S | 1 |
| Gandolfi, SA; Hamacher, T; Lim, J; Parra Restrepo, JC; Sanseau, AC | 1 |
| Alarcón-Martínez, L; Bernal-Garro, JM; García-Ayuso, D; Jiménez-López, M; Nadal-Nicolás, FM; Nieto-López, L; Ortín-Martínez, A; Valiente-Soriano, FJ; Vidal-Sanz, M; Villegas-Pérez, MP; Wheeler, LA | 1 |
| Agarwal, P; Agarwal, R; Ismail, NM; Kannan Kutty, M; Kapitonova, MY; Razali, N; Salmah Bakar, N; Smirnov, A | 1 |
| García-López, A; Hartleben, C; Jiménez-Román, J; Paczka, JA | 1 |
| Abassi, YA; Irelan, J; Ke, N; Nguyen, K | 1 |
| Anand, G; Gelber, AC; Kochar, B; Shan, SJ; Zinreich, SJ | 1 |
| Belasco, KT; Cadena, MJ; Friedrichs, A; Hinek, A; Hong, HC; Hougier, F; Jackson, JM; Johnson, SM; Kerdel, FA; Palceski, D; Tanghetti, EA | 1 |
| Chindasub, P; Duong-Polk, KX; Hammond, D; Leung, CK; Lindsey, JD; Weinreb, RN | 1 |
| Guzman-Aranguez, A; Loma, P; Perez de Lara, MJ; Pintor, J | 1 |
| Azuchi, Y; Guo, X; Harada, C; Harada, T; Kimura, A; Mitamura, Y; Namekata, K; Noro, T; Semba, K; Yoshida, H | 1 |
| Carter, B; Charland, L; Fedorowicz, Z; van der Linden, MM; van Zuuren, EJ | 1 |
| Lewczuk, B; Przybylska-Gornowicz, B; Ziółkowska, N | 1 |
| Schleichert, R; Weiss, E | 1 |
| Jang, I; Jeoung, JW; Kim, H; Kim, KE; Kim, YJ; Moon, H; Park, KH | 1 |
| Rosen, A; Shagalov, DR; Weiss, E; Weiss, J | 1 |
| Kurysheva, NI | 2 |
| Bilgin, S; Çınar, E; Doğan, C; Karaca, A; Mangan, MS; Tuncer, I; Zengin, MÖ | 1 |
| Aiello, F; Bagetta, G; Cesareo, M; Corasaniti, MT; Nucci, C; Scuteri, D; Tonin, P | 1 |
| Al-Hashimi, S; Bartlett, JD; Hwang, LH; Landig, M; Lin, SR; Nejad, M | 1 |
| Ucar, F; Yener, Hİ | 1 |
| Bourgault, S; Houle, MC; Lajoie, C; Ringuet, J; Simonyan, D | 1 |
| Chambers, A; Cumpston, KL; Kershner, E; Tobarran, N; Wills, BK | 1 |
| Inoue, K; Ishida, K; Kunimatsu-Sanuki, S; Tomita, G | 1 |
| Kim, CY; Lee, JS | 1 |
| Attar, M; Luu, KT; Tamhane, M | 1 |
| Del Amo, EM; Ranta, VP; Urtti, A | 1 |
| Aihara, M; Kanazawa, M; Kawakita, K; Kojima, S; Nojima, T; Suganami, H; Tanihara, H; Yamamoto, T | 1 |
| Bigdeli, A; Feghhi, M; Makhmalzadeh, BS; SoleimaniBiatiani, E | 1 |
| Kim, KE; Kim, Y; Lee, CK; Rho, S; Shin, J | 1 |
| Alkahtani, HM; Alomar, AM; Bakheit, AH; Darwish, H | 1 |
| Aihara, M; Isobe, T; Kanazawa, M; Koizumi, N; Kojima, S; Minami, H; Suganami, H; Tanihara, H; Yamamoto, T | 1 |
52 review(s) available for quinoxalines and brimonidine tartrate
| Article | Year |
|---|---|
Role of alpha-adrenergic blockers in the treatment of benign prostatic hyperplasia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Carbachol; Humans; Male; Muscle Contraction; Phenylephrine; Prazosin; Prostatic Hyperplasia; Quinoxalines | 1990 |
Effects of temperature on alpha adrenoceptors in limb veins: role of receptor reserve.
Topics: Animals; Brimonidine Tartrate; Cold Temperature; Dogs; Extremities; Femoral Vein; Norepinephrine; Phenoxybenzamine; Phentolamine; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein; Skin; Vasoconstriction | 1986 |
Pharmacological advances in the treatment of glaucoma.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clonidine; Ethacrynic Acid; Glaucoma; Humans; Latanoprost; Prostaglandins; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes | 1994 |
The role of brimonidine in the treatment of open-angle glaucoma.
Topics: Adrenergic alpha-Agonists; Aqueous Humor; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Prostaglandins; Quinoxalines; Sympathomimetics | 1996 |
Preclinical evaluation of brimonidine.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cats; Cebus; Drug Evaluation, Preclinical; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Rabbits; Rats | 1996 |
Development and use of brimonidine in treating acute and chronic elevations of intraocular pressure: a review of safety, efficacy, dose response, and dosing studies.
Topics: Acute Disease; Adrenergic alpha-Agonists; Brimonidine Tartrate; Clinical Trials as Topic; Dose-Response Relationship, Drug; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety | 1996 |
Brimonidine: a new alpha2-adrenoreceptor agonist for glaucoma treatment.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Betaxolol; Brimonidine Tartrate; Clinical Trials as Topic; Dose-Response Relationship, Drug; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Timolol; Trabeculectomy | 1997 |
Beta-blocker-induced complications and the patient with glaucoma. Newer treatments to help reduce systemic adverse events.
Topics: Adrenergic beta-Antagonists; Brimonidine Tartrate; Cardiovascular System; Central Nervous System; Clonidine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Neurosecretory Systems; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Respiratory System; Sulfonamides; Thiophenes | 1998 |
Brimonidine. A review of its pharmacological properties and clinical potential in the management of open-angle glaucoma and ocular hypertension.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Clinical Trials as Topic; Glaucoma, Open-Angle; Humans; Ocular Hypertension; Quinoxalines | 1998 |
[Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost].
Topics: Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clonidine; Drug Therapy, Combination; Female; Glaucoma; Humans; Latanoprost; Male; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes | 1998 |
Selectivity of site of action and systemic effects of topical alpha agonists.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ophthalmic Solutions; Optic Nerve; Quinoxalines; Treatment Outcome | 1998 |
Assessment of ocular hypotensive mechanisms and additivity of antiglaucoma drugs in humans.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aqueous Humor; Brimonidine Tartrate; Clonidine; Drug Synergism; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 1999 |
The role of medical therapy in the rank order of glaucoma treatment.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser Therapy; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Trabeculectomy; Treatment Outcome | 1999 |
[Alpha-2 adrenergic agonists in the treatment of glaucoma].
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Brimonidine Tartrate; Clonidine; Glaucoma; Humans; Intraocular Pressure; Quinoxalines | 1999 |
Meta-analysis of the effect of latanoprost and brimonidine on intraocular pressure in the treatment of glaucoma.
Topics: Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines | 2000 |
The evolving pharmacotherapeutic profile of brimonidine, an alpha 2-adrenergic agonist, after four years of continuous use.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Glaucoma; Humans; Neuroprotective Agents; Ocular Hypertension; Quinoxalines; Receptors, Adrenergic, alpha-2 | 2000 |
Maintaining mitochondrial membrane impermeability. an opportunity for new therapy in glaucoma?
Topics: Animals; Apoptosis; bcl-X Protein; Brimonidine Tartrate; Cell Membrane Permeability; Glaucoma; Humans; Intraocular Pressure; Mitochondria; Pargyline; Propylamines; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Retinal Ganglion Cells; Signal Transduction | 2001 |
Clinical and economic impact of new trends in glaucoma treatment.
Topics: Adult; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Cost-Benefit Analysis; Critical Pathways; Decision Trees; Female; Glaucoma, Open-Angle; Humans; Male; Quinoxalines; Randomized Controlled Trials as Topic; Trabeculectomy | 2001 |
[New medical treatments of glaucoma. New strategies?].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Glaucoma; Humans; Prostaglandins; Quinoxalines | 2001 |
Oral toxicity of topical preparations.
Topics: Administration, Oral; Adrenal Cortex Hormones; Anesthetics, Local; Animals; Anti-Bacterial Agents; Benzoyl Peroxide; Brimonidine Tartrate; Calcitriol; Drug-Related Side Effects and Adverse Reactions; Fluorouracil; Imidazoles; Ointments; Quinoxalines; Salicylates; Vitamin A; Vitamin D; Zinc Oxide | 2002 |
Reappraising first-line treatment in glaucoma management.
Topics: Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Cloprostenol; Dinoprost; Drug Therapy, Combination; Glaucoma; Humans; Latanoprost; Lipids; Prostaglandins; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Travoprost | 2002 |
New topical drugs for open-angle glaucoma.
Topics: Administration, Topical; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cloprostenol; Glaucoma, Open-Angle; Humans; Latanoprost; Lipids; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Travoprost | 2003 |
Role of alpha-2 agonists in neuroprotection.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Glaucoma; Humans; Neuroprotective Agents; Quinoxalines; Receptors, Adrenergic, alpha-2; Retinal Ganglion Cells | 2003 |
[Anterior uveitis and topical brimonidine: a case report].
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Humans; Male; Quinoxalines; Uveitis, Anterior | 2004 |
[Latanoprost topical ophthalmic combinations].
Topics: Acetazolamide; Administration, Topical; Antihypertensive Agents; Brimonidine Tartrate; Dinoprost; Drug Combinations; Drug Therapy, Combination; Epinephrine; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Ophthalmic Solutions; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 2004 |
Successful management of orbital cellulitis and temporary visual loss after blepharoplasty.
Topics: Abscess; Adult; Anti-Bacterial Agents; Blepharoplasty; Blindness; Brimonidine Tartrate; Cavernous Sinus Thrombosis; Cellulitis; Clindamycin; Combined Modality Therapy; Decompression, Surgical; Dexamethasone; Drainage; Emergencies; Exophthalmos; Female; Gentamicins; Humans; Latanoprost; Nerve Compression Syndromes; Occupational Exposure; Optic Nerve Diseases; Orbital Diseases; Penicillins; Prostaglandins F, Synthetic; Quinoxalines; Streptococcal Infections; Streptococcus pyogenes; Surgical Wound Infection; Teaching; Timolol; Vancomycin; Vision Disorders | 2006 |
Meta-analysis of randomised controlled trials comparing latanoprost with brimonidine in the treatment of open-angle glaucoma, ocular hypertension or normal-tension glaucoma.
Topics: Administration, Topical; Aged; Antihypertensive Agents; Brimonidine Tartrate; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Randomized Controlled Trials as Topic; Treatment Outcome | 2007 |
Topical brimonidine 0.2%/timolol 0.5% ophthalmic solution: in glaucoma and ocular hypertension.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Clinical Trials as Topic; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Timolol; Treatment Outcome | 2006 |
Unintentional ingestion of brimonidine antiglaucoma drops: a case report and review of the literature.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Charcoal; Humans; Infant; Male; Poisoning; Quinoxalines | 2007 |
Efficacy and safety of brimonidine and dorzolamide for intraocular pressure lowering in glaucoma and ocular hypertension.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Clinical Trials as Topic; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Male; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome | 2007 |
The efficacy and harm of prostaglandin analogues for IOP reduction in glaucoma patients compared to dorzolamide and brimonidine: a systematic review.
Topics: Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Female; Glaucoma; Humans; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Prostaglandins, Synthetic; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Treatment Outcome | 2008 |
Meta-analysis of randomized controlled trials comparing timolol with brimonidine in the treatment of glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Glaucoma; Humans; Quinoxalines; Randomized Controlled Trials as Topic; Timolol; Treatment Outcome | 2008 |
Efficacy, safety, and current applications of brimonidine.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Timolol; Treatment Outcome | 2008 |
[Fixed combinations of glaucoma medications].
Topics: Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Cloprostenol; Drug Combinations; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Travoprost; Treatment Outcome | 2008 |
Experimental and clinical evidence for brimonidine as an optic nerve and retinal neuroprotective agent: an evidence-based review.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Humans; Neuroprotective Agents; Optic Neuropathy, Ischemic; Quinoxalines; Retina; Retinal Diseases; Vitreous Body | 2009 |
[Development of conjunctival hyperemia with the use of a fixed combination of latanoprost/timolol: systematic review and meta-analysis of clinical trials].
Topics: Aged; Brimonidine Tartrate; Clinical Trials as Topic; Cloprostenol; Conjunctival Diseases; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Glaucoma; Humans; Hyperemia; Latanoprost; Middle Aged; Ocular Hypertension; Odds Ratio; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Timolol; Travoprost | 2009 |
[Neuroprotection in glaucoma].
Topics: Betaxolol; Brimonidine Tartrate; Disease Progression; Glaucoma; Guanidines; Humans; Memantine; Neuroprotective Agents; Quinoxalines; Sulfonamides; Thiophenes | 2007 |
Meta-analysis of medical intervention for normal tension glaucoma.
Topics: Aged; Amides; Antihypertensive Agents; Betaxolol; Bimatoprost; Brimonidine Tartrate; Cloprostenol; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Thiazines; Thiophenes; Timolol; Tonometry, Ocular; Travoprost | 2009 |
Safety and tolerability of brimonidine purite 0.1% and brimonidine purite 0.15%: a meta-analysis of two phase 3 studies.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Osmolar Concentration; Quinoxalines; Randomized Controlled Trials as Topic; Withholding Treatment | 2009 |
Systematic review of intraocular pressure-lowering effects of adjunctive medications added to latanoprost.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Databases, Factual; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Optic Nerve Diseases; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol | 2009 |
Fixed combinations of dorzolamide-timolol and brimonidine-timolol in the management of glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Patient Selection; Quinoxalines; Risk Assessment; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2010 |
Brimonidine for glaucoma.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Quinoxalines | 2010 |
Recent clinical pearls from clinical trials in glaucoma.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Clinical Trials as Topic; Filtering Surgery; Glaucoma Drainage Implants; Humans; Intraocular Pressure; Low Tension Glaucoma; Ocular Hypertension; Quinoxalines; Timolol; Tonometry, Ocular | 2012 |
Efficacy and tolerability of fixed combination of brimonidine 0.2%/timolol 0.5% compared with fixed combination of dorzolamide 2%/timolol 0.5% in the treatment of patients with elevated intraocular pressure: a meta-analysis of randomized controlled trials
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Female; Humans; Intraocular Pressure; Male; Middle Aged; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2013 |
Neuroprotection for treatment of glaucoma in adults.
Topics: Adult; Antihypertensive Agents; Brimonidine Tartrate; Disease Progression; Glaucoma, Open-Angle; Humans; Neuroprotective Agents; Optic Nerve; Optic Nerve Diseases; Quinoxalines; Randomized Controlled Trials as Topic; Retinal Ganglion Cells; Timolol | 2013 |
Brimonidine tartrate for the treatment of facial flushing and erythema in rosacea.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Erythema; Humans; Quality of Life; Quinoxalines; Rosacea; Treatment Outcome | 2014 |
Rosacea: new and emerging treatments.
Topics: Administration, Cutaneous; Brimonidine Tartrate; Dermatologic Agents; Drug Design; Humans; Ivermectin; Oxymetazoline; Quality of Life; Quinoxalines; Randomized Controlled Trials as Topic; Rosacea | 2014 |
Brinzolamide plus brimonidine for the treatment of glaucoma: an update.
Topics: Adrenergic alpha-2 Receptor Agonists; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clinical Trials as Topic; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Quinoxalines; Sulfonamides; Thiazines | 2014 |
Brimonidine for erythema caused by rosacea.
Topics: Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Contraindications; Drug Costs; Drug Interactions; Erythema; Humans; Quinoxalines; Rosacea | 2014 |
Interventions for rosacea.
Topics: Anti-Infective Agents; Brimonidine Tartrate; Cyclosporine; Dermatologic Agents; Dicarboxylic Acids; Doxycycline; Female; Humans; Ivermectin; Male; Metronidazole; Middle Aged; Ophthalmic Solutions; Quinoxalines; Randomized Controlled Trials as Topic; Rosacea; Tetracycline | 2015 |
Evidence on the neuroprotective properties of brimonidine in glaucoma.
Topics: Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Quinoxalines; Randomized Controlled Trials as Topic; Vision Disorders; Visual Fields | 2020 |
Brimonidine tartrate ophthalmic solution 0.025% for redness relief: an overview of safety and efficacy.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Erythema; Humans; Hyperemia; Nasal Decongestants; Ophthalmic Solutions; Quality of Life; Quinoxalines; Receptors, Adrenergic | 2022 |
201 trial(s) available for quinoxalines and brimonidine tartrate
| Article | Year |
|---|---|
Effect of long-term rhGH administration in GH-deficient adults on fat cell epinephrine response.
Topics: Adenosine Deaminase; Adipose Tissue; Adult; Brimonidine Tartrate; Dose-Response Relationship, Drug; Epinephrine; Female; Growth Hormone; Humans; Isoproterenol; Lipolysis; Male; Quinoxalines; Recombinant Proteins | 1992 |
Human vascular smooth muscle responses mediated by alpha 2 mechanisms in vivo and in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Arteries; Brimonidine Tartrate; Dioxanes; Doxazosin; Forearm; Humans; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha | 1985 |
Effects of brimonidine on aqueous humor dynamics in human eyes.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Aged; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Double-Blind Method; Female; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines | 1995 |
The cardiovascular, pulmonary, and ocular hypotensive effects of 0.2% brimonidine.
Topics: Adrenergic alpha-Agonists; Adult; Betaxolol; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Exercise Test; Hemodynamics; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypotension; Ophthalmic Solutions; Quinoxalines; Respiration; Timolol | 1995 |
The efficacy of brimonidine in decreasing elevations in intraocular pressure after laser trabeculoplasty.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Double-Blind Method; Drug Tolerance; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Pharmaceutical Vehicles; Quinoxalines; Trabeculectomy | 1993 |
Brimonidine in the prevention of intraocular pressure elevation following argon laser trabeculoplasty.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Trabeculectomy | 1993 |
Measurement of brimonidine concentrations in human plasma by a highly sensitive gas chromatography/mass spectrometric assay.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Calibration; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Male; Quality Control; Quinoxalines | 1995 |
Clinical experience with brimonidine 0.2% and timolol 0.5% in glaucoma and ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety; Timolol; Treatment Outcome | 1996 |
A comparison of the safety and efficacy of twice daily brimonidine 0.2% versus betaxolol 0.25% in subjects with elevated intraocular pressure. The Brimonidine Study Group III.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Betaxolol; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety; Treatment Outcome | 1996 |
Brimonidine tartrate: a one-month dose response study.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Pupil; Quinoxalines; Visual Acuity | 1997 |
A 1-year study of brimonidine twice daily in glaucoma and ocular hypertension. A controlled, randomized, multicenter clinical trial. Chronic Brimonidine Study Group.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Pupil; Quinoxalines; Safety; Time Factors; Timolol; Treatment Outcome; Visual Acuity | 1997 |
Twelve-month results of an ongoing randomized trial comparing brimonidine tartrate 0.2% and timolol 0.5% given twice daily in patients with glaucoma or ocular hypertension. Brimonidine Study Group 2.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety; Timolol | 1998 |
Comparison of the efficacy of apraclonidine and brimonidine as aqueous suppressants in humans.
Topics: Adrenergic alpha-Agonists; Adult; Aqueous Humor; Brimonidine Tartrate; Clonidine; Female; Fluorophotometry; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Quinoxalines; Tonometry, Ocular | 1998 |
Lack of cross-reactive allergic response to brimonidine in patients with known apraclonidine allergy.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Clonidine; Cross Reactions; Drug Hypersensitivity; Eye Diseases; Follow-Up Studies; Glaucoma; Humans; Middle Aged; Quinoxalines; Time Factors | 1998 |
Effect of brimonidine tartrate on ocular hemodynamic measurements.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Blood Flow Velocity; Brimonidine Tartrate; Ciliary Arteries; Cross-Over Studies; Double-Blind Method; Eye; Hemodynamics; Humans; Intraocular Pressure; Middle Aged; Ocular Hypertension; Ophthalmic Artery; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Retinal Artery; Ultrasonography, Doppler, Color | 1998 |
Brimonidine tartrate 0.2% twice daily vs timolol 0.5% twice daily: 1-year results in glaucoma patients. Brimonidine Study Group.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety; Timolol; Treatment Outcome | 1999 |
Effects of brimonidine 0.2% on blue-yellow perimetry of glaucomatous patients.
Topics: Adrenergic alpha-Agonists; Aqueous Humor; Blood Pressure; Brimonidine Tartrate; Contrast Sensitivity; Cross-Over Studies; Double-Blind Method; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ophthalmic Solutions; Pupil; Quinoxalines; Visual Field Tests; Visual Fields | 1998 |
Pressure or progression?
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Disease Progression; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Quinoxalines; Timolol; Visual Fields | 1999 |
Apraclonidine 0.5% versus brimonidine 0.2% for the control of intraocular pressure elevation following anterior segment laser procedures.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrate; Chronic Disease; Clonidine; Female; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Male; Middle Aged; Observer Variation; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Trabeculectomy; Treatment Outcome | 1999 |
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension.
Topics: Adrenergic alpha-Antagonists; Blood Platelets; Brimonidine Tartrate; Colforsin; Cyclic AMP; Epinephrine; Female; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypertension; Male; Middle Aged; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Thermodynamics | 1999 |
Comparison of the early effects of brimonidine and apraclonidine as topical ocular hypotensive agents.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Fluorophotometry; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 1999 |
Long-term brimonidine therapy in glaucoma patients with apraclonidine allergy.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Chronic Disease; Clonidine; Drug Hypersensitivity; Female; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Quinoxalines | 1999 |
The short-term effect of adding brimonidine 0.2% to timolol treatment in patients with open-angle glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Brimonidine Tartrate; Drug Therapy, Combination; Female; Follow-Up Studies; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Timolol; Treatment Outcome | 1999 |
Efficacy of brimonidine 0.2% as adjunctive therapy for patients with glaucoma inadequately controlled with otherwise maximal medical therapy.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Chemotherapy, Adjuvant; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Retrospective Studies; Safety; Treatment Outcome | 1999 |
Effects of 0.2% brimonidine on ocular anterior structures.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Eye; Female; Humans; Intraocular Pressure; Male; Prospective Studies; Pupil; Quinoxalines; Ultrasonography; Visual Acuity | 1999 |
Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular hypertensive patients.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aqueous Humor; Brimonidine Tartrate; Double-Blind Method; Female; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Sclera; Time Factors; Venous Pressure | 1999 |
Control of intraocular pressure elevations after argon laser trabeculoplasty: comparison of brimonidine 0.2% to apraclonidine 1.0%.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser Therapy; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Trabeculectomy | 1999 |
Daily cost of newer glaucoma agents.
Topics: Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Gels; Glaucoma; Humans; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Solutions; Sulfonamides; Thiophenes; Timolol | 1999 |
The effect of brimonidine tartrate on retinal blood flow in patients with ocular hypertension [corrected].
Topics: Administration, Topical; Adrenergic alpha-Agonists; Blood Flow Velocity; Brimonidine Tartrate; Disease Progression; Double-Blind Method; Female; Glaucoma; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Retinal Vessels; Visual Fields | 1999 |
The effectiveness and safety of brimonidine as mono-, combination, or replacement therapy for patients with primary open-angle glaucoma or ocular hypertension: a post hoc analysis of an open-label community trial. Glaucoma Trial Study Group.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Brimonidine Tartrate; Cohort Studies; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines | 2000 |
Efficacy of brimonidine as replacement therapy in patients with open-angle glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quality of Life; Quinoxalines; Racial Groups | 2000 |
Ongoing clinical assessment of the safety profile and efficacy of brimonidine compared with timolol: year-three results. Brimonidine Study Group II.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Female; Glaucoma; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Timolol; Vision Tests | 2000 |
The effect of brimonidine tartrate on retinal blood flow in patients with ocular hypertension.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Double-Blind Method; Female; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Regional Blood Flow; Retinal Vessels; Visual Acuity; Visual Fields | 2000 |
The use of topical aqueous suppressants in the prevention of postoperative intraocular pressure elevation after pars plana vitrectomy with long-acting gas tamponade.
Topics: Administration, Topical; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Clonidine; Fluorocarbons; Humans; Intraocular Pressure; Ocular Hypertension; Prospective Studies; Quinoxalines; Sulfonamides; Sulfur Hexafluoride; Thiophenes; Timolol; Vitrectomy | 2000 |
The efficacy of 0.2% brimonidine for preventing intraocular pressure rise following argon laser trabeculoplasty.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser Therapy; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Safety; Trabeculectomy; Treatment Outcome | 1999 |
Comparison of brimonidine with latanoprost in the adjunctive treatment of glaucoma. ALPHAGAN/XALATAN Study Group.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Miotics; Ocular Hypertension; Pilocarpine; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome | 2000 |
Comparative acute effects of brimonidine 0.2% versus dorzolamide 2% combined with beta-blockers in glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiophenes; Tonometry, Ocular; Treatment Outcome | 2000 |
Effects of systemic beta-blocker therapy on the efficacy and safety of topical brimonidine and timolol. Brimonidine Study Groups 1 and 2.
Topics: Administration, Oral; Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Safety; Timolol | 2000 |
Clinical success and quality of life with brimonidine 0.2% or timolol 0.5% used twice daily in glaucoma or ocular t hypertension: a randomized clinical trial. Brimonidine Outcomes Study Group I.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Glaucoma; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quality of Life; Quinoxalines; Safety; Surveys and Questionnaires; Timolol; Treatment Outcome | 2000 |
Adipose tissue metabolism in young and middle-aged men after control for total body fatness.
Topics: Adipose Tissue; Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Agonists; Adult; Aging; Body Composition; Brimonidine Tartrate; Bucladesine; Cell Separation; Colforsin; Epinephrine; Glycerol; Humans; Isoproterenol; Lipolysis; Lipoprotein Lipase; Male; Middle Aged; Quinoxalines; Theophylline | 2000 |
Brimonidine 0.2% versus dorzolamide 2% each given three times daily to reduce intraocular pressure.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Safety; Sulfonamides; Thiophenes; Treatment Outcome | 2000 |
[Treatment of glaucoma with brimonidine (Alphagan 0.2%)].
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Child; Drug Therapy, Combination; Female; Glaucoma; Humans; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines | 2000 |
Comparison of the clinical success rates and quality of life effects of brimonidine tartrate 0.2% and betaxolol 0.25% suspension in patients with open-angle glaucoma and ocular hypertension. Brimonidine Outcomes Study Group II.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Betaxolol; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Drug Evaluation; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quality of Life; Quinoxalines; Safety; Suspensions; Treatment Outcome | 2000 |
Brimonidine and postoperative pressure spikes in cataract surgery.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Cataract Extraction; Double-Blind Method; Humans; Intraocular Pressure; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Postoperative Complications; Prospective Studies; Quinoxalines; Treatment Outcome | 2000 |
Therapeutic success of latanoprost 0.005% compared to brimonidine 0.2% in patients with open-angle glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Treatment Outcome | 2000 |
Heat, but not mechanical hyperalgesia, following adrenergic injections in normal human skin.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Analysis of Variance; Brimonidine Tartrate; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hot Temperature; Humans; Hyperalgesia; Male; Middle Aged; Nociceptors; Norepinephrine; Pain Threshold; Phenylephrine; Quinoxalines; Receptors, Adrenergic; Skin; Vasoconstrictor Agents | 2001 |
Evaluation and comparison between the effects on intraocular pressure and retinal blood flow of two antiglaucomatous drugs administered in monotherapy: brimonidine and latanoprost. Preliminary results.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Drug Evaluation; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Retinal Vessels | 2000 |
Aqueous humor flow in normal human eyes treated with brimonidine and timolol, alone and in combination.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aqueous Humor; Brimonidine Tartrate; Double-Blind Method; Drug Therapy, Combination; Female; Fluorescein; Fluorophotometry; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Timolol; Tonometry, Ocular | 2001 |
Vitreous concentration of topically applied brimonidine tartrate 0.2%.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Biological Availability; Brimonidine Tartrate; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Prospective Studies; Quinoxalines; Tissue Distribution; Vitrectomy; Vitreous Body | 2001 |
The efficacy and safety of latanoprost 0.005% once daily versus brimonidine 0.2% twice daily in open-angle glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Drug Evaluation; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Safety; Treatment Outcome | 2001 |
Efficacy of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers in adult patients with glaucoma or ocular hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Down-Regulation; Female; Glaucoma; Humans; Immunologic Factors; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quality of Life; Quinoxalines; Sulfonamides; Thiophenes | 2001 |
Brimonidine 0.2% versus apraclonidine 0.5% for prevention of intraocular pressure elevations after anterior segment laser surgery.
Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Blood Pressure; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Iris; Laser Therapy; Male; Ocular Hypertension; Ophthalmic Solutions; Postoperative Complications; Quinoxalines; Safety; Trabeculectomy | 2001 |
Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in primary open-angle glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Osmolar Concentration; Prospective Studies; Quinoxalines; Timolol | 2001 |
Effect of brimonidine tartrate on ocular hemodynamics in healthy volunteers.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Blood Pressure; Brimonidine Tartrate; Ciliary Arteries; Cross-Over Studies; Double-Blind Method; Female; Fluorescein Angiography; Heart Rate; Humans; Intraocular Pressure; Male; Ophthalmic Artery; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Retinal Artery; Tonometry, Ocular; Ultrasonography, Doppler, Color | 2001 |
Effectiveness and safety of brimonidine as adjunctive therapy for patients with elevated intraocular pressure in a large, open-label community trial.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Chemotherapy, Adjuvant; Community Medicine; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Quality of Life; Quinoxalines; Safety | 2001 |
Comparison of the clinical success and quality-of-life impact of brimonidine 0.2% and betaxolol 0.25 % suspension in patients with elevated intraocular pressure.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Betaxolol; Brimonidine Tartrate; Female; Humans; Intraocular Pressure; Male; Middle Aged; Multicenter Studies as Topic; Ocular Hypertension; Quality of Life; Quinoxalines; Treatment Outcome | 2001 |
Effect of topical brimonidine on intraocular pressure after small incision cataract surgery.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Double-Blind Method; Female; Humans; Intraocular Pressure; Lens Implantation, Intraocular; Male; Minimally Invasive Surgical Procedures; Ocular Hypertension; Phacoemulsification; Postoperative Complications; Prospective Studies; Quinoxalines | 2001 |
Clinical and economic impact of new trends in glaucoma treatment.
Topics: Adult; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Cost-Benefit Analysis; Critical Pathways; Decision Trees; Female; Glaucoma, Open-Angle; Humans; Male; Quinoxalines; Randomized Controlled Trials as Topic; Trabeculectomy | 2001 |
Safety and efficacy of brimonidine in children with glaucoma.
Topics: Adolescent; Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Central Nervous System Diseases; Child; Child, Preschool; Female; Glaucoma; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Quinoxalines; Safety; Tonometry, Ocular | 2001 |
[Prevention of early postoperative increase in intraocular pressure after phacoemulsification. Comparison of different antiglaucoma drugs].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Data Interpretation, Statistical; Double-Blind Method; Drug Therapy, Combination; Humans; Intraocular Pressure; Lens Implantation, Intraocular; Middle Aged; Ophthalmic Solutions; Phacoemulsification; Polysaccharides, Bacterial; Postoperative Care; Postoperative Complications; Quinoxalines; Sulfonamides; Thiophenes; Time Factors; Timolol | 2001 |
Latanoprost and brimonidine: therapeutic and physiologic assessment before and after oral nonsteroidal anti-inflammatory therapy.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Contrast Sensitivity; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Indomethacin; Intraocular Pressure; Laser-Doppler Flowmetry; Latanoprost; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Retinal Vessels; Visual Fields | 2002 |
A comparison of the efficacy and tolerability of brimonidine and latanoprost in adults with open-angle glaucoma or ocular hypertension: a three-month, multicenter, randomized, double-masked, parallel-group trial.
Topics: Adrenergic alpha-Agonists; Aged; Antihypertensive Agents; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Patient Satisfaction; Prostaglandins F, Synthetic; Quinoxalines; Treatment Outcome | 2001 |
Three-month comparison of brimonidine and latanoprost as adjunctive therapy in glaucoma and ocular hypertension patients uncontrolled on beta-blockers: tolerance and peak intraocular pressure lowering.
Topics: Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Brimonidine Tartrate; Chronic Disease; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Quality of Life; Quinoxalines; Treatment Outcome | 2002 |
Intraocular pressure-lowering effects of latanoprost and brimonidine therapy in patients with open-angle glaucoma or ocular hypertension: a randomized observer-masked multicenter study.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Treatment Outcome | 2002 |
Twelve-month evaluation of brimonidine-purite versus brimonidine in patients with glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Conjunctivitis, Allergic; Double-Blind Method; Drug Evaluation; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Patient Satisfaction; Preservatives, Pharmaceutical; Quality of Life; Quinoxalines; Safety | 2002 |
A short term study of the additive effect of timolol and brimonidine on intraocular pressure.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Timolol | 2002 |
Cardiovascular effects of timolol maleate, brimonidine or brimonidine/timolol maleate in concomitant therapy.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Blood Pressure; Brimonidine Tartrate; Cardiovascular System; Cross-Over Studies; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Electrocardiography; Exercise; Exercise Test; Female; Heart Rate; Humans; Male; Prospective Studies; Quinoxalines; Timolol | 2002 |
Does glaucoma medication influence the diameter of the retinal arteriole in the human eye? (A pilot study using the retinal vessel analyser).
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Arterioles; Betaxolol; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Glaucoma; Humans; Latanoprost; Middle Aged; Ophthalmology; Pilot Projects; Prostaglandins F, Synthetic; Quinoxalines; Retinal Artery; Sulfonamides; Thiazines; Timolol | 2001 |
[Use of brimonidine 0.2% in treatment of glaucoma or ocular hypertony after poorly tolerated beta-blocker treatment].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Appetite; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Patient Satisfaction; Quality of Life; Quinoxalines; Surveys and Questionnaires; Treatment Failure; Treatment Outcome | 2002 |
Effect of latanoprost 0.005% and brimonidine tartrate 0.2% on pulsatile ocular blood flow in normal tension glaucoma.
Topics: Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Eye; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Pulsatile Flow; Quinoxalines | 2002 |
Effects of acute topical administration of clonidine 0.125%, apraclonidine 1.0% and brimonidine 0.2% on visual field parameters and ocular perfusion pressure in patients with primary open-angle glaucoma.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Blood Pressure; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Quinoxalines; Visual Fields | 2002 |
Comparison of latanoprost, brimonidine and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with primary open-angle glaucoma and ocular hypertension.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Cross-Over Studies; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2002 |
Efficacy of brimonidine 0.2 per cent as adjunctive therapy to beta-blockers: a comparative study between POAG and CACG in Asian eyes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Drug Therapy, Combination; Female; Glaucoma, Angle-Closure; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Prospective Studies; Quinoxalines; Thailand; Treatment Outcome | 2002 |
Effect of single and multiple doses of 0.2% brimonidine tartrate in the glaucomatous Beagle.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Heart Rate; Intraocular Pressure; Male; Ophthalmic Solutions; Pupil; Quinoxalines; Tonometry, Ocular | 2002 |
Changes in intraocular pressure and ocular perfusion pressure after latanoprost 0.005% or brimonidine tartrate 0.2% in normal-tension glaucoma patients.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cross-Over Studies; Drug Evaluation; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Optic Disk; Optic Nerve Diseases; Prostaglandins F, Synthetic; Quinoxalines; Vision Disorders; Visual Fields | 2002 |
The short-term IOP-lowering effect of brimonidine 0.2% and dorzolomide 2% combination in primary open-angle glaucoma.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Evaluation; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Middle Aged; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiophenes | 2002 |
[The ocular hypotensive effect and safety of 0.2% brimonidine].
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines | 2001 |
Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy and tolerability.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Safety; Sulfonamides; Thiophenes; Timolol; Visual Acuity; Visual Fields | 2003 |
A 3-month comparison of efficacy and safety of brimonidine-purite 0.15% and brimonidine 0.2% in patients with glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Conjunctiva; Conjunctivitis, Allergic; Dose-Response Relationship, Drug; Double-Blind Method; Glaucoma; Humans; Hyperemia; Intraocular Pressure; Ocular Hypertension; Quinoxalines; Severity of Illness Index | 2003 |
The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Cross-Over Studies; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Posture; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2003 |
Unoprostone as adjunctive therapy to timolol: a double masked randomised study versus brimonidine and dorzolamide.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Chemotherapy, Adjuvant; Dinoprost; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiophenes; Timolol | 2003 |
The effects of latanoprost and brimonidine on blood flow velocity of the retrobulbar vessels: a 3-month clinical trial.
Topics: Blood Flow Velocity; Brimonidine Tartrate; Ciliary Arteries; Eye; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Ophthalmic Artery; Prostaglandins F, Synthetic; Quinoxalines; Retinal Artery; Ultrasonography, Doppler, Color; Vascular Resistance | 2003 |
Efficacy and safety of timolol maleate/latanoprost fixed combination versus timolol maleate and brimonidine given twice daily.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Drug Administration Schedule; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Safety; Timolol | 2003 |
Comparison between latanoprost and brimonidine efficacy and safety in Indian eyes.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Treatment Outcome | 2003 |
[The effect of brimonidine on postoperative hypertonia after an extracapsular cataract extraction].
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Cataract Extraction; Female; Humans; Male; Middle Aged; Ocular Hypertension; Postoperative Complications; Postoperative Period; Prospective Studies; Quinoxalines; Treatment Outcome | 2003 |
The efficacy and safety of brimonidine 0.2% compared with timolol 0.5% in glaucoma: a randomized clinical trial on Taiwanese patients.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Brimonidine Tartrate; Female; Glaucoma; Heart; Humans; Male; Quinoxalines; Retrospective Studies; Timolol | 2003 |
Evaluation of neuroprotective qualities of brimonidine during LASIK.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Color Perception; Contrast Sensitivity; Double-Blind Method; Drug Evaluation; Female; Humans; Keratomileusis, Laser In Situ; Male; Middle Aged; Myopia; Nerve Fibers; Neuroprotective Agents; Ophthalmic Solutions; Optic Nerve; Pupil; Quinoxalines; Visual Acuity; Visual Fields | 2003 |
Short posterior ciliary artery, central retinal artery, and choroidal hemodynamics in brimonidine-treated primary open-angle glaucoma patients.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Blood Flow Velocity; Brimonidine Tartrate; Choroid; Ciliary Arteries; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Middle Aged; Prospective Studies; Quinoxalines; Retinal Artery; Ultrasonography | 2003 |
Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Analysis of Variance; Brimonidine Tartrate; Contrast Sensitivity; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Timolol | 2003 |
Randomised controlled trial comparing the effect of brimonidine and timolol on visual field loss after acute primary angle closure.
Topics: Acute Disease; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Disease Progression; Female; Glaucoma, Angle-Closure; Humans; Linear Models; Male; Middle Aged; Prospective Studies; Quinoxalines; Timolol; Visual Field Tests; Visual Fields | 2004 |
Efficacy of brimonidine 0.2% in controlling acute postoperative intraocular pressure elevation after phacoemulsification.
Topics: Acute Disease; Adrenergic alpha-Agonists; Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Female; Humans; Intraocular Pressure; Lens Implantation, Intraocular; Lenses, Intraocular; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Phacoemulsification; Postoperative Complications; Prospective Studies; Quinoxalines; Treatment Outcome | 2003 |
Efficacy and safety of brimonidine, dorzolamide and latanoprost as adjunctive therapy in primary open angle glaucoma.
Topics: Administration, Topical; Adolescent; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Chemotherapy, Adjuvant; Child; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome | 2003 |
Aqueous humor flow in normal human eyes treated with brimonidine and dorzolamide, alone and in combination.
Topics: Administration, Topical; Adult; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Cornea; Double-Blind Method; Drug Therapy, Combination; Female; Fluorescein; Fluorophotometry; Humans; Intraocular Pressure; Male; Manometry; Middle Aged; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiophenes | 2004 |
Efficacy and safety of the latanoprost/timolol maleate fixed combination vs concomitant brimonidine and latanoprost therapy.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 2004 |
The safety and efficacy of unoprostone 0.15% versus brimonidine 0.2%.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Cross-Over Studies; Dinoprost; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety; Treatment Outcome | 2004 |
Brimonidine 0.2% vs unoprostone 0.15% both added to timolol maleate 0.5% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Dinoprost; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Quinoxalines; Timolol; Treatment Outcome | 2005 |
Dorzolamide/Timolol fixed combination versus concomitant administration of brimonidine and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measures.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Patient Satisfaction; Prospective Studies; Quinoxalines; Safety; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2004 |
Comparison of the safety and efficacy of dorzolamide 2% and brimonidine 0.2% in patients with glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cross-Over Studies; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Safety; Sulfonamides; Thiophenes; Treatment Outcome | 2004 |
[Efficiency of brimonidine 0.2% and dorzolamide 2% as adjunctive therapy to beta-blockers].
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quality of Life; Quinoxalines; Sulfonamides; Thiophenes; Tonometry, Ocular; Treatment Outcome | 2004 |
Increased tyrosine phosphorylation mediates the cooling-induced contraction and increased vascular reactivity of Raynaud's disease.
Topics: Adrenergic alpha-Agonists; Adult; Angiotensin II; Arterioles; Brimonidine Tartrate; Cold Temperature; Enzyme Inhibitors; Female; Genistein; Humans; Middle Aged; Phosphorylation; Protein-Tyrosine Kinases; Quinoxalines; Raynaud Disease; Serotonin; Signal Transduction; Skin; Skin Temperature; Tyrosine; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents | 2004 |
Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol-dorzolamide combination.
Topics: Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Drug Synergism; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Latanoprost; Male; Middle Aged; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2005 |
A comparison of the fixed combination of latanoprost and timolol with the unfixed combination of brimonidine and timolol in patients with elevated intraocular pressure. A six month, evaluator masked, multicentre study in Europe.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Europe; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Timolol; Treatment Outcome | 2004 |
Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes | 2004 |
Miotic effect of brimonidine tartrate 0.15% ophthalmic solution in normal eyes.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Dark Adaptation; Female; Humans; Intraocular Pressure; Light; Male; Ophthalmic Solutions; Pupil; Quinoxalines | 2004 |
Effect of topical brinzolamide 1% and brimonidine 0.2% on intraocular pressure after phacoemulsification.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Double-Blind Method; Female; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Phacoemulsification; Postoperative Complications; Prospective Studies; Quinoxalines; Sulfonamides; Thiazines; Tonometry, Ocular | 2004 |
The comparative cardiovascular, pulmonary, ocular blood flow, and ocular hypotensive effects of topical travoprost, bimatoprost, brimonidine, and betaxolol.
Topics: Administration, Topical; Adult; Amides; Betaxolol; Bimatoprost; Brimonidine Tartrate; Cardiovascular System; Cloprostenol; Cross-Over Studies; Double-Blind Method; Eye; Humans; Intraocular Pressure; Lipids; Male; Ocular Hypotension; Prospective Studies; Pulmonary Circulation; Quinoxalines; Regional Blood Flow; Travoprost | 2004 |
Diurnal intraocular pressure and blood pressure with two dosing regimens of brimonidine in normal tension glaucoma.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Blood Pressure; Brimonidine Tartrate; Circadian Rhythm; Drug Administration Schedule; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Quinoxalines | 2004 |
Comparison of the efficacy and safety of dorzolamide 2% when added to brimonidine 0.2% or timolol maleate 0.5% in patients with primary open-angle glaucoma.
Topics: Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Safety; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2005 |
Latanoprost or brimonidine as treatment for elevated intraocular pressure: multicenter trial in the United States.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Safety; Tonometry, Ocular; Treatment Outcome; United States | 2005 |
The Low-pressure Glaucoma Treatment Study (LoGTS) study design and baseline characteristics of enrolled patients.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Disease Progression; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Research Design; Timolol; Visual Field Tests; Visual Fields | 2005 |
[The effect of brimonidine on the pupillary reflex. A pupillographic study in healthy volunteers].
Topics: Acetazolamide; Brimonidine Tartrate; Humans; Intraocular Pressure; Quinoxalines; Reaction Time; Reference Values; Reflex, Pupillary | 2005 |
Topical brimonidine reduces collateral damage caused by laser photocoagulation for choroidal neovascularization.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Choroidal Neovascularization; Double-Blind Method; Female; Humans; Laser Coagulation; Male; Neuroprotective Agents; Ophthalmic Solutions; Pilot Projects; Prospective Studies; Quinoxalines; Retinal Diseases; Visual Acuity | 2005 |
24-hour intraocular pressures with brimonidine purite versus dorzolamide added to latanoprost in primary open-angle glaucoma subjects.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Cross-Over Studies; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Safety; Sulfonamides; Thiophenes; Visual Acuity | 2005 |
The efficacy of topical administration of brimonidine to reduce ischaemia in the very early stage of diabetic retinopathy in good controlled type-2 diabetes mellitus.
Topics: Aneurysm; Antihypertensive Agents; Blood Glucose; Brimonidine Tartrate; Diabetes Mellitus, Type 2; Diabetic Retinopathy; Humans; Ischemia; Middle Aged; Prospective Studies; Quinoxalines; Time Factors; Treatment Outcome; Vision, Ocular | 2004 |
Prophylaxis for second eye involvement in leber hereditary optic neuropathy: an open-labeled, nonrandomized multicenter trial of topical brimonidine purite.
Topics: Administration, Topical; Adolescent; Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; DNA, Mitochondrial; Female; Functional Laterality; Humans; Male; Middle Aged; Mutation; Optic Atrophy, Hereditary, Leber; Pilot Projects; Premedication; Prospective Studies; Quinoxalines; Treatment Outcome; Visual Acuity; Visual Fields | 2005 |
Brimonidine versus dapiprazole: Influence on pupil size at various illumination levels.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dark Adaptation; Diagnostic Techniques, Ophthalmological; Humans; Light; Ophthalmic Solutions; Piperazines; Prospective Studies; Pupil; Quinoxalines; Triazoles | 2005 |
Brimonidine and timolol fixed-combination therapy versus monotherapy: a 3-month randomized trial in patients with glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Double-Blind Method; Drug Combinations; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Timolol; Treatment Outcome | 2005 |
Efficacy and tolerability of 0.2% brimonidine tartrate for the treatment of acute non-arteritic anterior ischemic optic neuropathy (NAION): a 3-month, double-masked, randomised, placebo-controlled trial.
Topics: Acute Disease; Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Optic Neuropathy, Ischemic; Quinoxalines; Time Factors; Treatment Outcome; Vision Disorders; Visual Acuity; Visual Fields | 2006 |
Brimonidine 0.15% versus apraclonidine 0.5% for prevention of intraocular pressure elevation after anterior segment laser surgery.
Topics: Adrenergic alpha-Agonists; Aged; Anterior Eye Segment; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Heart Rate; Humans; Intraocular Pressure; Iridectomy; Laser Therapy; Lens Capsule, Crystalline; Male; Ocular Hypertension; Postoperative Complications; Quinoxalines; Trabeculectomy; Treatment Outcome; Visual Acuity | 2005 |
Comparison of the effects of brimonidine 0.2% and timolol 0.5% on retinal nerve fiber layer thickness in ocular hypertensive patients: a prospective, unmasked study.
Topics: Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Administration Schedule; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Instillation, Drug; Intraocular Pressure; Male; Middle Aged; Nerve Fibers; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Retina; Time Factors; Timolol | 2005 |
Comparative analysis of the effects of brimonidine and dorzolamide on ocular blood flow velocity in patients with newly diagnosed primary open-angle glaucoma.
Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Brimonidine Tartrate; Eye; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Instillation, Drug; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome; Ultrasonography, Doppler, Color | 2006 |
A randomized, investigator-masked, 4-week study comparing timolol maleate 0.5%, brinzolamide 1%, and brimonidine tartrate 0.2% as adjunctive therapies to travoprost 0.004% in adults with primary open-angle glaucoma or ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cloprostenol; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Quinoxalines; Sulfonamides; Thiazines; Timolol; Travoprost | 2006 |
Progression of visual field defects in leber hereditary optic neuropathy: experience of the LHON treatment trial.
Topics: Administration, Topical; Adolescent; Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Optic Atrophy, Hereditary, Leber; Pilot Projects; Prospective Studies; Quinoxalines; Vision Disorders; Visual Field Tests; Visual Fields | 2006 |
An evaluation of the rate of nonresponders to latanoprost therapy.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Drug Resistance; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Pilocarpine; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Timolol; Tonometry, Ocular | 2006 |
Effects of topical hypotensive drugs on circadian IOP, blood pressure, and calculated diastolic ocular perfusion pressure in patients with glaucoma.
Topics: Administration, Topical; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Circadian Rhythm; Diastole; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Perfusion; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2006 |
Brimonidine 0.2% versus brimonidine Purite 0.15%: prophylactic effect on iop elevation after Nd:YAG laser posterior capsulotomy.
Topics: Aged; Brimonidine Tartrate; Double-Blind Method; Female; Humans; Intraocular Pressure; Laser Therapy; Lens Capsule, Crystalline; Male; Middle Aged; Ocular Hypertension; Postoperative Complications; Prospective Studies; Quinoxalines | 2006 |
[Use of antiglaucoma therapy to reduce acute intraocular pressure rise following neodymium: YAG laser iridotomy in angle-closure glaucoma patients].
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Female; Glaucoma, Angle-Closure; Humans; Iris; Laser Therapy; Latanoprost; Male; Middle Aged; Miotics; Ocular Hypertension; Pilocarpine; Postoperative Complications; Prostaglandins F, Synthetic; Quinoxalines | 2006 |
The safety and intraocular pressure-lowering efficacy of brimonidine tartrate 0.15% preserved with polyquaternium-1.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Chlorine Compounds; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Oxides; Polymers; Preservatives, Pharmaceutical; Quinoxalines; Therapeutic Equivalency | 2006 |
Twice-daily 0.2% brimonidine-0.5% timolol fixed-combination therapy vs monotherapy with timolol or brimonidine in patients with glaucoma or ocular hypertension: a 12-month randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Timolol; Tonometry, Ocular; Treatment Outcome | 2006 |
Visual field and intraocular pressure asymmetry in the low-pressure glaucoma treatment study.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Brimonidine Tartrate; Circadian Rhythm; Double-Blind Method; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Quinoxalines; Timolol; Visual Fields | 2007 |
Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure.
Topics: Aged; Brimonidine Tartrate; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Instillation, Drug; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiophenes; Timolol | 2007 |
Special considerations in low-tension glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Neuroprotective Agents; Optic Nerve Diseases; Quinoxalines; Retinal Ganglion Cells; Timolol; Vision Disorders; Visual Field Tests; Visual Fields | 2007 |
Comparison of the ocular hypotensive efficacy of adjunctive brimonidine 0.15% or brinzolamide 1% in combination with travoprost 0.004%.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Circadian Rhythm; Cloprostenol; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiazines; Travoprost; Treatment Outcome | 2007 |
Twenty-four-hour efficacy of the brimonidine/timolol fixed combination versus therapy with the unfixed components.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Drug Administration Schedule; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Time Factors; Timolol; Treatment Outcome | 2008 |
Effects of topical clonidine versus brimonidine on choroidal blood flow and intraocular pressure during squatting.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Blood Flow Velocity; Brimonidine Tartrate; Choroid; Clonidine; Cross-Over Studies; Double-Blind Method; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Male; Posture; Quinoxalines; Regional Blood Flow; Tonometry, Ocular | 2007 |
Effect of prophylactic brimonidine instillation on bleeding during strabismus surgery in adults.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Conjunctival Diseases; Double-Blind Method; Eye Hemorrhage; Female; Humans; Hyaluronic Acid; Male; Oculomotor Muscles; Phenylephrine; Premedication; Quinoxalines; Strabismus | 2007 |
Ocular comfort of combination glaucoma therapies: brimonidine 0.2%/timolol 0.5% compared with dorzolamide 2%/timolol 0.5%.
Topics: Administration, Topical; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Patient Compliance; Patient Satisfaction; Quinoxalines; Sulfonamides; Thiophenes; Timolol | 2007 |
Brimonidine 0.2% versus brimonidine Purite 0.15% in Asian ocular hypertension.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Asia; Asian People; Brimonidine Tartrate; Conjunctivitis, Allergic; Cross-Over Studies; Female; Humans; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Pigment Epithelium of Eye; Preservatives, Pharmaceutical; Prospective Studies; Quinoxalines; Single-Blind Method; Therapeutic Equivalency | 2007 |
Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Dark Adaptation; Diagnostic Techniques, Ophthalmological; Female; Humans; Intraocular Pressure; Male; Miotics; Ophthalmic Solutions; Pupil; Quinoxalines | 2007 |
Effect of antiglaucoma agents on postoperative intraocular pressure after cataract surgery with Viscoat.
Topics: Acetazolamide; Acetylcholine; Administration, Topical; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Chondroitin; Chondroitin Sulfates; Double-Blind Method; Drug Combinations; Female; Humans; Hyaluronic Acid; Intraocular Pressure; Lens Implantation, Intraocular; Male; Middle Aged; Ocular Hypertension; Phacoemulsification; Postoperative Complications; Prospective Studies; Quinoxalines; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular | 2007 |
Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Intraocular Pressure; Lens Implantation, Intraocular; Male; Ocular Hypertension; Phacoemulsification; Postoperative Care; Postoperative Complications; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2008 |
A pilot study of topical treatment with an alpha2-agonist in patients with retinal dystrophies.
Topics: Administration, Topical; Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Brimonidine Tartrate; Contrast Sensitivity; Electroretinography; Female; Humans; Male; Middle Aged; Patient Compliance; Pilot Projects; Prospective Studies; Quinoxalines; Retinal Degeneration; Retinal Diseases; Retinitis Pigmentosa; Treatment Outcome; Visual Acuity; Visual Fields | 2008 |
Brimonidine purite 0.1% versus brinzolamide 1% as adjunctive therapy to latanoprost in patients with glaucoma or ocular hypertension.
Topics: Adult; Aged; Analysis of Variance; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Maximum Tolerated Dose; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Organization and Administration; Probability; Prostaglandins F, Synthetic; Quinoxalines; Risk Assessment; Severity of Illness Index; Single-Blind Method; Sulfonamides; Thiazines; Tonometry, Ocular; Treatment Outcome | 2008 |
Brimonidine-purite 0.1% versus brimonidine-purite 0.15% twice daily in glaucoma or ocular hypertension: a 12-month randomized trial.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Administration Schedule; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Treatment Outcome | 2008 |
Changes in visual function after intraocular pressure reduction using antiglaucoma medications.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Cloprostenol; Contrast Sensitivity; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Timolol; Travoprost; Visual Acuity; Visual Fields; Visual Perception | 2009 |
Comparison of allergy rates in glaucoma patients receiving brimonidine 0.2% monotherapy versus fixed-combination brimonidine 0.2%-timolol 0.5% therapy.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Conjunctivitis, Allergic; Drug Therapy, Combination; Female; Glaucoma; Humans; Male; Middle Aged; Quinoxalines; Timolol | 2008 |
An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome; Young Adult | 2008 |
Brimonidine and apraclonidine as vasoconstrictors in adjustable strabismus surgery.
Topics: Adrenergic alpha-Agonists; Adult; Blood Loss, Surgical; Brimonidine Tartrate; Clonidine; Combined Modality Therapy; Conjunctiva; Humans; Middle Aged; Pilot Projects; Prospective Studies; Quinoxalines; Strabismus; Vasoconstriction; Vasoconstrictor Agents | 2009 |
Three-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapy.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Female; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Osmolar Concentration; Quinoxalines; Sulfonamides; Thiophenes; Time Factors; Timolol | 2009 |
Brimonidine tartrate 0.15%, dorzolamide hydrochloride 2%, and brinzolamide 1% compared as adjunctive therapy to prostaglandin analogs.
Topics: Aged; Aged, 80 and over; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Cloprostenol; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Single-Blind Method; Sulfonamides; Thiazines; Thiophenes; Tonometry, Ocular; Travoprost; Treatment Outcome | 2009 |
Fixed-combination brimonidine/timolol as adjunctive therapy to a prostaglandin analog: a 3-month, open-label, replacement study in glaucoma patients.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Drug Hypersensitivity; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Time Factors; Timolol | 2009 |
Use of brimonidine before LASIK with femtosecond laser-created flaps for the correction of myopia: a contralateral eye study.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Double-Blind Method; Follow-Up Studies; Humans; Keratomileusis, Laser In Situ; Lasers, Excimer; Myopia; Ophthalmic Solutions; Postoperative Complications; Quinoxalines; Surgical Flaps; Time Factors; Treatment Outcome | 2010 |
Effect of brimonidine/timolol fixed combination on preventing the short-term intraocular pressure increase after intravitreal injection of ranibizumab.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Combinations; Female; Humans; Injections, Intralesional; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Placebo Effect; Quinoxalines; Ranibizumab; Timolol; Treatment Outcome; Vitreous Body | 2010 |
Comparison of ocular hypotensive actions of fixed combinations of brimonidine/timolol and dorzolamide/timolol.
Topics: Aged; Aged, 80 and over; Algorithms; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Dosage Forms; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiophenes; Timolol | 2010 |
Measurement of adherence to brimonidine therapy for glaucoma using electronic monitoring.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Monitoring; Female; Glaucoma, Open-Angle; Health Behavior; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Medication Adherence; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Tonometry, Ocular | 2011 |
Bimatoprost 0.03% versus brimonidine 0.2% in the prevention of intraocular pressure spike following neodymium:yttrium–aluminum–garnet laser posterior capsulotomy.
Topics: Aged; Aged, 80 and over; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Capsule Opacification; Cataract; Cloprostenol; Female; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Lasers, Solid-State; Male; Middle Aged; Neodymium; Ocular Hypertension; Ophthalmic Solutions; Posterior Capsule of the Lens; Quinoxalines; Tonometry, Ocular | 2010 |
Effect of prophylactic topical brimonidine (0.15%) administration on the development of subconjunctival hemorrhage after intravitreal injection.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Conjunctival Diseases; Double-Blind Method; Eye Hemorrhage; Female; Humans; Intraocular Pressure; Intravitreal Injections; Male; Middle Aged; Prospective Studies; Quinoxalines | 2011 |
Adherence with brimonidine in patients with glaucoma aware and not aware of electronic monitoring.
Topics: Administration, Topical; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Monitoring; Female; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Medication Adherence; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Patient Compliance; Prospective Studies; Quinoxalines; Visual Acuity | 2011 |
Control of intraocular pressure and fluctuation with fixed-combination brimonidine-timolol versus brimonidine or timolol monotherapy.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Double-Blind Method; Drug Combinations; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Quinoxalines; Timolol; Tonometry, Ocular | 2011 |
Effect of a fixed brimonidine-timolol combination on intraocular pressure after phacoemulsification.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Cataract Extraction; Double-Blind Method; Drug Combinations; Female; Humans; Intraocular Pressure; Lens Implantation, Intraocular; Male; Middle Aged; Ocular Hypertension; Phacoemulsification; Prospective Studies; Quinoxalines; Time Factors; Timolol | 2011 |
A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Double-Blind Method; Female; Follow-Up Studies; Gonioscopy; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Timolol; Tonometry, Ocular; Treatment Outcome; Vision Disorders; Visual Acuity; Visual Fields | 2011 |
Pupillometry study of brimonidine tartrate 0.2% and apraclonidine 0.5%.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Brimonidine Tartrate; Clonidine; Double-Blind Method; Female; Humans; Male; Miotics; Photometry; Pupil; Quinoxalines; Young Adult | 2011 |
Effect of brimonidine on corneal thickness.
Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Cornea; Double-Blind Method; Epithelium, Corneal; Female; Follow-Up Studies; Humans; Intraocular Pressure; Male; Prospective Studies; Quinoxalines; Time Factors; Young Adult | 2011 |
Diurnal intraocular pressure efficacy of the timolol-brimonidine fixed combination and the timolol-dorzolamide fixed combination as a first choice therapy in patients with pseudoexfoliation glaucoma.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Drug Administration Schedule; Drug Combinations; Exfoliation Syndrome; Female; Follow-Up Studies; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Single-Blind Method; Sulfonamides; Thiophenes; Time Factors; Timolol; Treatment Outcome; Visual Acuity | 2011 |
Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Medication Adherence; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Time Factors; Timolol; Treatment Outcome | 2012 |
Once-daily topical brimonidine tartrate gel 0·5% is a novel treatment for moderate to severe facial erythema of rosacea: results of two multicentre, randomized and vehicle-controlled studies.
Topics: Administration, Cutaneous; Adolescent; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Brimonidine Tartrate; Dermatologic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythema; Facial Dermatoses; Female; Gels; Humans; Male; Middle Aged; Quinoxalines; Rosacea; Treatment Outcome; Young Adult | 2012 |
Short-term effects of brimonidine/timolol and dorzolamide/timolol on ocular perfusion pressure and blood flow in glaucoma.
Topics: Administration, Ophthalmic; Aged; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Male; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular | 2012 |
Effects of crystalloid versus colloid and the α-2 agonist brimonidine versus placebo on intraocular pressure during prone spine surgery: a factorial randomized trial.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Brimonidine Tartrate; Chemistry, Pharmaceutical; Colloids; Crystalloid Solutions; Female; Humans; Intraocular Pressure; Intraoperative Care; Isotonic Solutions; Male; Middle Aged; Prone Position; Quinoxalines; Spinal Cord Diseases; Treatment Outcome | 2012 |
Fixed-combination brimonidine-timolol versus latanoprost in glaucoma and ocular hypertension: a 12-week, randomized, comparison study.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Time Factors; Timolol; Treatment Outcome | 2012 |
A study of initial therapy for glaucoma in southern India: India Glaucoma Outcomes and Treatment (INGOT) Study.
Topics: Aged; Antihypertensive Agents; Antimetabolites, Antineoplastic; Brimonidine Tartrate; Drug Combinations; Female; Fluorouracil; Glaucoma; Humans; India; Intraocular Pressure; Latanoprost; Lens Implantation, Intraocular; Male; Middle Aged; Phacoemulsification; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Surveys and Questionnaires; Thiophenes; Timolol; Tonometry, Ocular; Trabeculectomy; Visual Acuity | 2012 |
A double-masked randomized crossover study comparing the effect of latanoprost/timolol and brimonidine/timolol fixed combination on intraocular pressure and ocular blood flow in patients with primary open-angle glaucoma or ocular hypertension.
Topics: Aged; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Cross-Over Studies; Double-Blind Method; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Laser-Doppler Flowmetry; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Time Factors; Timolol; Ultrasonography, Doppler, Color | 2012 |
Fixed combination brimonidine-timolol versus brimonidine for treatment of intraocular pressure elevation after neodymium:YAG laser posterior capsulotomy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Capsule Opacification; Drug Combinations; Female; Follow-Up Studies; Humans; Intraocular Pressure; Lasers, Solid-State; Male; Middle Aged; Phacoemulsification; Preoperative Care; Quinoxalines; Timolol; Treatment Outcome | 2012 |
[Efficacy of prophylactic treatment of intraocular pressure spikes due to intravitreal injections].
Topics: Acetazolamide; Aged; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Brimonidine Tartrate; Chemoprevention; Clonidine; Drug Combinations; Female; Humans; Hypotonic Solutions; Intraocular Pressure; Intravitreal Injections; Macular Degeneration; Male; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome | 2012 |
Risk factors for visual field progression in the low-pressure glaucoma treatment study.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Disease Progression; Double-Blind Method; Female; Follow-Up Studies; Gonioscopy; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Risk Factors; Timolol; Vision Disorders; Visual Acuity; Visual Field Tests; Visual Fields | 2012 |
[Effect of topical 0.1% brimonidine tartrate and 0.5% timolol maleate on pulmonary and cardiovascular functions].
Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Aged; Blood Pressure; Brimonidine Tartrate; Cardiovascular System; Electrocardiography; Female; Humans; Lung; Male; Pulse; Quinoxalines; Timolol | 2012 |
[Phase III clinical trial of brimonidine in patients with primary open-angle glaucoma and ocular hypertension--comparison of the effects of brimonidine monotherapy versus timolol monotherapy, or combination brimonidine/prostaglandins therapy versus combin
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins; Quinoxalines; Timolol; Treatment Outcome | 2012 |
Phase 3 randomized 3-month trial with an ongoing 3-month safety extension of fixed-combination brinzolamide 1%/brimonidine 0.2%.
Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Aged; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiazines; Time Factors; Treatment Outcome | 2013 |
Effect of prophylactic intraocular pressure-lowering medication on pain during cataract surgery.
Topics: Acetazolamide; Adult; Aged; Aged, 80 and over; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Cataract; Cloprostenol; Combined Modality Therapy; Drug Combinations; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Pain; Phacoemulsification; Postoperative Period; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Travoprost | 2013 |
Effects of dorzolamide-timolol and brimonidine-timolol on retinal vascular autoregulation and ocular perfusion pressure in primary open angle glaucoma.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Cross-Over Studies; Drug Combinations; Eye; Female; Glaucoma, Open-Angle; Homeostasis; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Regional Blood Flow; Sulfonamides; Thiophenes; Timolol | 2013 |
Comparison of 24-hour intraocular pressure reduction obtained with brinzolamide/timolol or brimonidine/timolol fixed-combination adjunctive to travoprost therapy.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Cloprostenol; Cross-Over Studies; Drug Combinations; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Time Factors; Timolol; Travoprost | 2013 |
Three-month randomized trial of fixed-combination brinzolamide, 1%, and brimonidine, 0.2%.
Topics: Academic Medical Centers; Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Aged; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Diagnostic Techniques, Ophthalmological; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Least-Squares Analysis; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Predictive Value of Tests; Private Practice; Quinoxalines; Sulfonamides; Thiazines; Time Factors; Treatment Outcome; United States | 2013 |
Comparison of acetazolamide, brimonidine, and anterior chamber paracentesis for ocular hypertension control after initial intravitreal bevacizumab injection: a randomized clinical trial.
Topics: Acetazolamide; Administration, Oral; Administration, Topical; Aged; Angiogenesis Inhibitors; Anterior Chamber; Antibodies, Monoclonal, Humanized; Antihypertensive Agents; Bevacizumab; Brimonidine Tartrate; Female; Humans; Intraocular Pressure; Intravitreal Injections; Male; Middle Aged; Ocular Hypertension; Paracentesis; Quinoxalines; Tonometry, Ocular | 2014 |
Fixed-combination brinzolamide 1%/brimonidine 0.2% vs monotherapy with brinzolamide or brimonidine in patients with open-angle glaucoma or ocular hypertension: results of a pooled analysis of two phase 3 studies.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiazines; Visual Acuity | 2013 |
Comparison of dorzolamide/timolol versus brimonidine/timolol fixed combination therapy in the management of steroid-induced ocular hypertension.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Diabetic Retinopathy; Drug Combinations; Female; Glucocorticoids; Humans; Intraocular Pressure; Intravitreal Injections; Macular Edema; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Triamcinolone Acetonide | 2015 |
Dilute brimonidine to improve patient comfort and subconjunctival hemorrhage after LASIK.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Conjunctival Diseases; Double-Blind Method; Drug Therapy, Combination; Eye Hemorrhage; Female; Histamine H1 Antagonists; Humans; Hyperemia; Keratomileusis, Laser In Situ; Lasers, Excimer; Male; Middle Aged; Naphazoline; Patient Satisfaction; Pheniramine; Postoperative Complications; Prospective Studies; Quinoxalines; Refraction, Ocular; Refractive Surgical Procedures; Visual Acuity; Young Adult | 2013 |
Efficacy and safety of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of two randomized, double-blind, and vehicle-controlled pivotal studies.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Dermatologic Agents; Double-Blind Method; Facial Dermatoses; Female; Follow-Up Studies; Gels; Humans; Male; Middle Aged; Quinoxalines; Rosacea; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2013 |
Evaluation of brimonidine-timolol fixed combination in patients of primary open-angle glaucoma.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Timolol; Treatment Outcome | 2013 |
Role of brimonidine in the treatment of clinically significant macular edema with ischemic changes in diabetic maculopathy.
Topics: Adrenergic alpha-2 Receptor Agonists; Aged; Brimonidine Tartrate; Diabetic Retinopathy; Female; Humans; Ischemia; Macular Edema; Male; Middle Aged; Prospective Studies; Quinoxalines; Retinal Vessels; Visual Acuity | 2014 |
Long-term safety and efficacy of once-daily topical brimonidine tartrate gel 0.5% for the treatment of moderate to severe facial erythema of rosacea: results of a 1-year open-label study.
Topics: Administration, Cutaneous; Administration, Topical; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Erythema; Face; Female; Humans; Male; Middle Aged; Quinoxalines; Rosacea; Social Behavior; Treatment Outcome; Young Adult | 2014 |
Comparative pharmacokinetics and bioavailability of brimonidine following ocular and dermal administration of brimonidine tartrate ophthalmic solution and gel in patients with moderate-to-severe facial erythema associated with rosacea.
Topics: Administration, Cutaneous; Adrenergic alpha-2 Receptor Agonists; Adult; Area Under Curve; Biological Availability; Brimonidine Tartrate; Drug Administration Schedule; Facial Dermatoses; Female; Gels; Humans; Male; Ophthalmic Solutions; Quinoxalines; Rosacea | 2014 |
Risk factors for optic disc hemorrhage in the low-pressure glaucoma treatment study.
Topics: Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Double-Blind Method; Female; Follow-Up Studies; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Optic Disk; Proportional Hazards Models; Quinoxalines; Retinal Hemorrhage; Risk Factors; Timolol | 2014 |
Effect of brimonidine on retinal vascular autoregulation and short-term visual function in normal tension glaucoma.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Blood Flow Velocity; Brimonidine Tartrate; Female; Homeostasis; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Ophthalmic Solutions; Posture; Prospective Studies; Quinoxalines; Retinal Vessels; Visual Acuity; Visual Field Tests; Visual Fields | 2014 |
Improvement in facial erythema within 30 minutes of initial application of brimonidine tartrate in patients with rosacea.
Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Dermatologic Agents; Double-Blind Method; Erythema; Female; Gels; Humans; Male; Middle Aged; Quinoxalines; Rosacea; Severity of Illness Index; Time Factors; Treatment Outcome; Young Adult | 2014 |
Efficacy of combined administration of 0.2% brimonidine and 0.5% betaxolol in treatment of primary open angle glaucoma and ocular hypertension.
Topics: Aged; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Drug Administration Schedule; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ocular Hypotension; Quinoxalines; Tonometry, Ocular; Treatment Outcome | 2013 |
Twice-daily brinzolamide/brimonidine fixed combination versus brinzolamide or brimonidine in open-angle glaucoma or ocular hypertension.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiazines | 2014 |
Randomized trial of brinzolamide/brimonidine versus brinzolamide plus brimonidine for open-angle glaucoma or ocular hypertension.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Quinoxalines; Sulfonamides; Thiazines; Tonometry, Ocular; Treatment Outcome | 2014 |
Efficacy and tolerability of fixed-combination bimatoprost/timolol versus fixed-combination dorzolamide/brimonidine/timolol in patients with primary open-angle glaucoma or ocular hypertension: a multicenter, prospective, crossover study.
Topics: Administration, Topical; Aged; Aged, 80 and over; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Circadian Rhythm; Cloprostenol; Cross-Over Studies; Double-Blind Method; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Tonometry, Ocular; Treatment Outcome | 2014 |
Effect of brimonidine tartrate 0.15% on scotopic pupil size and upper eyelid position: controlled trial.
Topics: Adolescent; Adult; Brimonidine Tartrate; Child; Eyelids; Female; Humans; Male; Middle Aged; Ophthalmic Solutions; Pupil; Quinoxalines; Young Adult | 2021 |
Ripasudil-Brimonidine Fixed-Dose Combination vs Ripasudil or Brimonidine: Two Phase 3 Randomized Clinical Trials.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Prospective Studies; Quinoxalines; Randomized Controlled Trials as Topic; Treatment Outcome | 2023 |
Comparisons of efficacy and safety between preserved and preservative-free brimonidine tartrate in glaucoma and ocular hypertension: a parallel-grouped, randomized trial.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Double-Blind Method; Glaucoma; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Preservatives, Pharmaceutical; Quinoxalines; Treatment Outcome | 2023 |
Crossover Randomized Study of Pharmacologic Effects of Ripasudil-Brimonidine Fixed-Dose Combination Versus Ripasudil or Brimonidine.
Topics: Adult; Antihypertensive Agents; Brimonidine Tartrate; Endothelial Cells; Glaucoma, Open-Angle; Humans; Hyperemia; Intraocular Pressure; Male; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines | 2023 |
989 other study(ies) available for quinoxalines and brimonidine tartrate
| Article | Year |
|---|---|
UK-14,304, R(-)-alpha-methyl-histamine and SMS 201-995 block plasma protein leakage within dura mater by prejunctional mechanisms.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Capillary Permeability; Capsaicin; Dura Mater; Electric Stimulation; Guinea Pigs; Histamine Agonists; Injections, Intravenous; Male; Methylhistamines; Octreotide; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Histamine; Receptors, Histamine H3; Receptors, Somatostatin; Substance P | 1992 |
Endogenous nitric oxide modulates sympathetic neuroeffector transmission in the isolated rabbit lateral saphenous vein.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Electric Stimulation; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenylephrine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Saphenous Vein; Sympathetic Nervous System; Synaptic Transmission | 1992 |
Drop in the "atypical" beta-adrenergic response and modification of the beta/alpha 2-adrenoceptor balance in fat cells from aging rabbits.
Topics: Adipose Tissue; Adrenocorticotropic Hormone; Aging; Animals; Brimonidine Tartrate; Epinephrine; Ethanolamines; In Vitro Techniques; Isoproterenol; Lipolysis; Propanolamines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1992 |
Platelet alpha-2 adrenergic receptor binding and plasma free 3-methoxy-4-hydroxyphenylethylene glycol in depressed patients before and after treatment with mianserin.
Topics: Aged; Biomarkers; Blood Platelets; Brimonidine Tartrate; Depressive Disorder; Female; Humans; Ligands; Male; Methoxyhydroxyphenylglycol; Mianserin; Psychiatric Status Rating Scales; Quinoxalines; Receptors, Adrenergic, alpha | 1992 |
Naloxone-induced bradycardia in pithed rats: evidence for an interaction with the peripheral sympathetic nervous system and alpha-2 adrenoceptors.
Topics: Animals; Atropine; Brimonidine Tartrate; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Male; Methacholine Chloride; Naloxone; Phentolamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sympathetic Nervous System | 1992 |
The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Cell Line; Cyclic AMP; Dioxanes; GTP-Binding Proteins; Idazoxan; Immunoblotting; Insulin; Insulin Secretion; Kinetics; Membranes; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tritium; Virulence Factors, Bordetella; Yohimbine | 1992 |
Alpha 2-C10 adrenergic receptors expressed in rat 1 fibroblasts can regulate both adenylylcyclase and phospholipase D-mediated hydrolysis of phosphatidylcholine by interacting with pertussis toxin-sensitive guanine nucleotide-binding proteins.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cholera Toxin; DNA, Recombinant; Endothelins; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Hydrolysis; Inositol Phosphates; Pertussis Toxin; Phosphatidylcholines; Phospholipase D; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1992 |
Influence of age on control of norepinephrine release from the rat tail artery.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Aging; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Norepinephrine; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Dopamine; Tail; Yohimbine | 1992 |
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Analgesics; Brimonidine Tartrate; Bucladesine; Calcium; Calmodulin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Cytosol; Edetic Acid; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Quinoxalines; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Gz-mediated hormonal inhibition of cyclic AMP accumulation.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Chorionic Gonadotropin; Colforsin; Cyclic AMP; Dinoprostone; Dopamine; Gene Expression Regulation; GTP-Binding Proteins; Hormones; In Vitro Techniques; Lysophospholipids; Pertussis Toxin; Quinoxalines; Rats; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1992 |
Mechanisms of signal transduction for adenosine and ATP in pulmonary vascular bed.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cats; Dinoprost; GTP-Binding Proteins; Indomethacin; Methoxamine; Pertussis Toxin; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Quinoxalines; Signal Transduction; Thromboxane A2; Virulence Factors, Bordetella; Xanthines | 1992 |
Preferential desensitization of beta- versus alpha 2-adrenergic receptors accelerates loss of response to norepinephrine in primary glial cultures.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Female; Isoproterenol; Neuroglia; Norepinephrine; Pregnancy; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1992 |
Characteristics of the alpha 2/beta-adrenoceptor-coupled adenylate cyclase system and their relationship with adrenergic responsiveness in hamster fat cells from different anatomical sites.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Colforsin; Cricetinae; Dioxanes; Epididymis; Epinephrine; GTP-Binding Proteins; Idazoxan; Isoproterenol; Kinetics; Lipolysis; Macromolecular Substances; Male; Mesocricetus; Organ Specificity; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Skin; Theophylline | 1992 |
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. I. Coupling of alpha 2-adrenergic receptor subtypes to distinct G-proteins.
Topics: 3T3 Cells; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Membrane; Colforsin; Cyclic AMP; Epinephrine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Kinetics; Mice; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Signal Transduction; Transfection; Virulence Factors, Bordetella; Yohimbine | 1992 |
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. II. Preferential coupling of the alpha 2C-adrenergic receptor to the guanine nucleotide-binding protein, Go.
Topics: 3T3 Cells; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Membrane; Epinephrine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Immunoblotting; Kinetics; Membrane Proteins; Mice; Plasmids; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha; Signal Transduction; Transfection; Yohimbine | 1992 |
Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Binding, Competitive; Brain; Brain Mapping; Brimonidine Tartrate; Clonidine; Depressive Disorder; Female; Humans; Male; Middle Aged; Quinoxalines; Radioligand Assay; Receptors, Adrenergic; Schizophrenia; Schizophrenic Psychology; Suicide; Violence | 1992 |
Acute ethanol intoxication may not alter alpha 2-adrenoceptors in the human brain.
Topics: Adrenergic alpha-Agonists; Adult; Alcoholic Intoxication; Brain; Brimonidine Tartrate; Clonidine; Female; Humans; Kinetics; Male; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha | 1992 |
Modulation of noradrenergic transmission by neuropeptide Y and presynaptic alpha 2-adrenergic receptors in the hypothalamus of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Electric Stimulation; Hypertension; Hypothalamus; In Vitro Techniques; Male; Neuropeptide Y; Norepinephrine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Synaptic Transmission | 1992 |
Variable alpha 2-adrenoceptor-mediated inhibition of bronchoconstriction and peptide release upon activation of pulmonary afferents.
Topics: Adrenergic alpha-Agonists; Afferent Pathways; Animals; Bradykinin; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Diterpenes; Electric Stimulation; Guinea Pigs; Imidazoles; In Vitro Techniques; Lung; Neurokinin A; Nicotine; Peptides; Quinoxalines; Vagus Nerve | 1992 |
Opposite rank order of potency for alpha-2 adrenoceptor agonists on water and solute excretion in the rat: two sites and/or receptors?
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Clonidine; Diuresis; Dose-Response Relationship, Drug; Infusions, Intra-Arterial; Kidney; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sodium | 1992 |
SK&F 104078, a post-junctionally selective alpha 2-adrenoceptor antagonist in the human saphenous vein in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Benzazepines; Brimonidine Tartrate; Humans; In Vitro Techniques; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Quinoxalines; Saphenous Vein | 1992 |
Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera. Changes in receptor/GTP-binding protein interaction following agonist binding.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Line; Clonidine; Electrophoresis, Polyacrylamide Gel; GTP-Binding Proteins; Immune Sera; Iodine Radioisotopes; Precipitin Tests; Quinoxalines; Receptors, Adrenergic, alpha; Swine; Yohimbine | 1992 |
A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents.
Topics: Adrenergic alpha-Agonists; Animals; Asparagine; Aspartic Acid; Brimonidine Tartrate; Calcium Channels; Cell Line; Clonidine; GTP-Binding Proteins; Membrane Potentials; Mutagenesis, Site-Directed; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Receptors, Somatostatin; Recombinant Proteins; Somatostatin; Transfection | 1992 |
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1992 |
Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Doxazosin; Drug Implants; Eating; Food; Male; Morphine; Morphine Dependence; Motor Activity; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome | 1992 |
Loss of high-affinity alpha 2-adrenoceptors in Alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus.
Topics: Adrenergic alpha-Agonists; Aged; Alzheimer Disease; Autoradiography; Binding, Competitive; Brimonidine Tartrate; Frontal Lobe; Hippocampus; Humans; Quinoxalines; Receptors, Adrenergic, alpha; Reference Values | 1992 |
Pharmacological characterization of presynaptic alpha 2-autoreceptors in rat submaxillary gland and heart atrium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Heart Atria; In Vitro Techniques; Kinetics; Male; Methoxamine; Norepinephrine; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Submandibular Gland | 1992 |
Modulation of non-adrenergic non-cholinergic inhibitory neurotransmission in rat gastric fundus by the alpha 2-adrenoceptor agonist, UK-14,304.
Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Brimonidine Tartrate; Electric Stimulation; Gastric Fundus; In Vitro Techniques; Male; Muscle Relaxation; Nitric Oxide; Prazosin; Quinoxalines; Rats; Rats, Wistar; Synaptic Transmission; Vasoactive Intestinal Peptide; Yohimbine | 1992 |
Factors determining the specificity of signal transduction by guanine nucleotide-binding protein-coupled receptors. III. Coupling of alpha 2-adrenergic receptor subtypes in a cell type-specific manner.
Topics: 3T3 Cells; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Cell Line; Colforsin; Cyclic AMP; Edetic Acid; Egtazic Acid; Epinephrine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Kinetics; Manganese; Mice; Muscle, Smooth; PC12 Cells; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, beta; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1992 |
Localization of alpha-2 adrenergic receptors in the human eye.
Topics: Adrenergic alpha-Agonists; Aged; Autoradiography; Brimonidine Tartrate; Eye; Female; Humans; Ligands; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha | 1992 |
Platelet membrane alpha 2-adrenergic receptors in depression.
Topics: Adrenergic alpha-Agonists; Adult; Antidepressive Agents; Bipolar Disorder; Blood Platelets; Brimonidine Tartrate; Depressive Disorder; Female; Follow-Up Studies; Humans; Magnesium; Male; Methoxyhydroxyphenylglycol; Middle Aged; Quinoxalines; Radioligand Assay; Receptors, Adrenergic | 1992 |
Anxiolytic-like effects of alpha-2-adrenoceptor agonists on conflict behavior in the rat: pre- versus postsynaptic receptor mechanisms.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Anxiety Agents; Benzylamines; Brain Chemistry; Brimonidine Tartrate; Conflict, Psychological; Female; Mydriatics; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sympathomimetics; Synapses; Yohimbine | 1992 |
Pharmacological evidence for heterogeneity of ocular alpha 2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Cats; Ciliary Body; Cyclic AMP; Dose-Response Relationship, Drug; Iris; Nictitating Membrane; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Yohimbine | 1992 |
Quantitative in vitro and ex vivo autoradiography of the alpha 2-adrenoceptor antagonist [3H]atipamezole.
Topics: Adolescent; Adrenergic alpha-Antagonists; Adult; Animals; Autoradiography; Brain; Brimonidine Tartrate; Dioxanes; Humans; Idazoxan; Imidazoles; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tissue Distribution | 1992 |
Amplification of alpha adrenergic vasoconstriction in canine isolated mesenteric artery and vein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Dogs; Dose-Response Relationship, Drug; Endothelins; Female; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Potassium Chloride; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Vasoconstriction | 1992 |
Decreased density of presynaptic alpha 2-adrenoceptors in postmortem brains of patients with Alzheimer's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Alpha-Globulins; Alzheimer Disease; Brimonidine Tartrate; Cadaver; Dementia; Humans; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Reference Values; Synapses; Tissue Distribution | 1992 |
Evidence for direct vasoconstrictor activity of melatonin in "pressurized" segments of isolated caudal artery from juvenile rats.
Topics: Aging; Animals; Antihypertensive Agents; Arteries; Brimonidine Tartrate; Female; In Vitro Techniques; Male; Melatonin; Muscle, Smooth, Vascular; Quinoxalines; Rats; Rats, Wistar; Vasoconstrictor Agents | 1992 |
Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery.
Topics: Animals; Arginine; Bradykinin; Brimonidine Tartrate; Calcimycin; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Indomethacin; Isometric Contraction; Membrane Potentials; Nitroarginine; Quinoxalines; Thrombin; Vasodilation | 1992 |
Molecular interaction of the human alpha 2-C10-adrenergic receptor, when expressed in Rat-1 fibroblasts, with multiple pertussis toxin-sensitive guanine nucleotide-binding proteins: studies with site-directed antisera.
Topics: Animals; Brimonidine Tartrate; Cells, Cultured; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Immune Sera; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella; Yohimbine | 1991 |
Alpha 1- and alpha 2-adrenoceptors at different levels of the canine saphenous vein.
Topics: Animals; Brimonidine Tartrate; Dioxanes; Dogs; Electric Stimulation; Epinephrine; In Vitro Techniques; Inositol; Inositol Phosphates; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein; Synapses; Yohimbine | 1991 |
Synergistic interactions between alpha 1- and alpha 2-adrenergic receptors in activating 3H-inositol phosphate formation in primary glial cell cultures.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Cells, Cultured; Dose-Response Relationship, Drug; Inositol Phosphates; Neuroglia; Norepinephrine; Osmolar Concentration; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Time Factors; Tritium; Yohimbine | 1991 |
Regulation of noradrenaline release from rat occipital cortex tissue chops by alpha 2-adrenergic agonists.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Brimonidine Tartrate; Bucladesine; Clonidine; Colforsin; Cyclic AMP; Histological Techniques; Male; Norepinephrine; Occipital Lobe; Quinoxalines; Rats; Rats, Inbred Strains | 1991 |
Cholera toxin impairment of opioid-mediated inhibition of adenylate cyclase in neuroblastoma x glioma hybrid cells is due to a toxin-induced decrease in opioid receptor levels.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Brimonidine Tartrate; Cholera Toxin; Colforsin; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hybrid Cells; Immunoblotting; Neuroblastoma; Pertussis Toxin; Quinoxalines; Receptors, Opioid; Receptors, Opioid, delta; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Estimation of agonist dissociation constants at central presynaptic alpha-2 autoreceptors in the absence of autoinhibition.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Techniques; Male; Norepinephrine; Quinolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha | 1991 |
Effects of centrally administered anxiolytic agents on classically conditioned bradycardia.
Topics: Animals; Anti-Anxiety Agents; Arousal; Brain; Brain Mapping; Brimonidine Tartrate; Clonidine; Conditioning, Classical; Corticotropin-Releasing Hormone; Enkephalin, Methionine; Heart Rate; Male; Peptide Fragments; Quinoxalines; Rats; Reflex, Startle | 1991 |
Alpha-adrenoceptor subtypes and regional myocardial blood flow distribution during coronary occlusion in dogs.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Coronary Circulation; Coronary Vessels; Dogs; Female; Imidazoles; Male; Muscle, Smooth, Vascular; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
The pharmacology of fluparoxan: a selective alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Aorta; Body Temperature; Brimonidine Tartrate; Clonidine; Guinea Pigs; Heart Rate; Ileum; In Vitro Techniques; Male; Muscle, Smooth; Norepinephrine; Piperoxan; Postural Balance; Pyrroles; Quinoxalines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine; Receptors, Muscarinic; Receptors, Serotonin; Vas Deferens | 1991 |
Regulation of the alpha 2A-adrenergic receptor in the HT29 cell line. Effects of insulin and growth factors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding Sites; Blotting, Northern; Brimonidine Tartrate; Cyclic AMP; Dioxanes; Flow Cytometry; Glycolysis; Growth Substances; Humans; Idazoxan; Insulin; Kinetics; Nucleic Acid Hybridization; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Tumor Cells, Cultured | 1991 |
Effects of chronic alpha 2-adrenoceptor blockade on platelet and lymphocyte adrenoceptor binding in normal volunteers.
Topics: Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Humans; Idazoxan; Lymphocytes; Male; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Up-Regulation; Yohimbine | 1991 |
Selective alpha 2-adrenergic agonists B-HT 920 and UK14304-18. Effects on aqueous humor dynamics in monkeys.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Aqueous Humor; Azepines; Brimonidine Tartrate; Intraocular Pressure; Macaca fascicularis; Quinoxalines; Time Factors; Tonometry, Ocular | 1991 |
Mechanisms of vasoconstrictor responses to KCl in rat isolated perfused tail arteries: interaction with the alpha 2-adrenoceptor agonist UK14304.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; In Vitro Techniques; Male; Perfusion; Potassium Chloride; Quinoxalines; Rats; Rats, Inbred Strains; Reserpine; Vasoconstriction | 1991 |
Influence of some alpha 2-receptor agonists and antagonists on the excitatory non-adrenergic, non-cholinergic neurotransmission in the airways of guinea-pigs in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; Guinea Pigs; Imidazoles; Male; Medetomidine; Quinoxalines; Respiratory Muscles; Respiratory System; Synaptic Transmission; Vagus Nerve | 1991 |
Postjunctional alpha-adrenoceptors in the rabbit isolated distal saphenous artery: indirect sensitivity to prazosin of responses to noradrenaline mediated via postjunctional alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Brimonidine Tartrate; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Signal transduction in Rat-1 fibroblasts expressing high levels of the alpha 2-C10 adrenergic receptor.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Line; Cholera Toxin; Fibroblasts; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Macromolecular Substances; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1991 |
Alpha 2-adrenoceptor activation inhibits noradrenaline release in human and rabbit isolated renal arteries.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Animals; Brimonidine Tartrate; Clonidine; Female; Humans; In Vitro Techniques; Kidney; Male; Middle Aged; Norepinephrine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Renal Artery; Sympathetic Nervous System; Tetrodotoxin; Yohimbine | 1991 |
Additional evidence for functional subclassification of alpha-2 adrenoceptors based on a new selective antagonist, SK&F 104856.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atrial Function; Benzazepines; Binding, Competitive; Brimonidine Tartrate; Dogs; Electric Stimulation; Female; Guinea Pigs; Heart Atria; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Rabbits; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Synaptic Transmission; Tritium; Vas Deferens | 1991 |
Contraction-mediating alpha 2-adrenoceptors in the mouse vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Drug Interactions; Idazoxan; Male; Mice; Muscle Contraction; Neuropeptide Y; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Suramin; Vas Deferens; Yohimbine | 1991 |
Differences between full and partial alpha-adrenoceptor agonists in eliciting phasic and tonic types of responses in the longitudinal smooth muscle of the rat portal vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Clonidine; Imidazoles; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phenoxybenzamine; Portal Vein; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Vasoconstriction | 1991 |
Modulation of calcium currents via alpha 2-adrenoceptors in embryonic chick sympathetic neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Chick Embryo; Clonidine; Electric Stimulation; Electrophysiology; Ganglia, Sympathetic; Neurons; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Sympathetic Nervous System | 1991 |
Ability of SK&F 104078 and SK&F 104856 to identify alpha-2 adrenoceptor subtypes in NCB20 cells and guinea pig lung.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Cells, Cultured; Clonidine; Cricetinae; Dibenzazepines; Imidazoles; Indoles; Isoindoles; Lung; Mice; Neuroblastoma; Neurons; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha; Tritium; Tumor Cells, Cultured; Yohimbine | 1991 |
Platelet alpha 2-adrenoceptors, defined with agonist and antagonist ligands, in depressed patients, prior to and following treatment.
Topics: Adrenergic alpha-Agonists; Binding, Competitive; Blood Platelets; Brimonidine Tartrate; Depressive Disorder; Electroconvulsive Therapy; Humans; Imipramine; Lofepramine; Psychiatric Status Rating Scales; Quinoxalines; Radioligand Assay; Receptors, Adrenergic; Yohimbine | 1991 |
Electrically evoked noradrenaline release from cultured chick sympathetic neurons: modulation via presynaptic alpha-adrenoceptors and lack of autoinhibition.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Chick Embryo; Cocaine; Electric Stimulation; Neurons; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Sympathetic Nervous System; Tritium; Yohimbine | 1991 |
Behavioral and receptor binding analysis of the alpha 2-adrenergic agonist, 5-bromo-6 [2-imidazoline-2-yl amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an alpha 2-adrenoceptor subtype.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Behavior, Animal; Blood Pressure; Brain; Brimonidine Tartrate; Cognition; Dioxanes; Female; Guanfacine; Hypnotics and Sedatives; Idazoxan; Macaca mulatta; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical; Yohimbine | 1991 |
Endogenous nitric oxide modulates adrenergic neural vasoconstriction in guinea-pig pulmonary artery.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Electric Stimulation; Epoprostenol; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Norepinephrine; omega-N-Methylarginine; Pulmonary Artery; Quinoxalines; Receptors, Adrenergic; Sympathetic Nervous System; Vasoconstriction | 1991 |
Comparison of the effects of four dendrotoxin peptides, 4-aminopyridine and tetraethylammonium on the electrically evoked [3H]noradrenaline release from rat hippocampus.
Topics: 4-Aminopyridine; Adrenergic alpha-Agonists; Animals; Binding, Competitive; Brimonidine Tartrate; Clonidine; Elapid Venoms; Electric Stimulation; Hippocampus; Male; Norepinephrine; Peptide Fragments; Peptides; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetraethylammonium; Tetraethylammonium Compounds; Tritium | 1991 |
Regionally specific age-dependent decline in alpha 2-adrenoceptors: an autoradiographic study in human brain.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Aging; Autoradiography; Brain; Brimonidine Tartrate; Clonidine; Humans; Middle Aged; Organ Specificity; Postmortem Changes; Quinoxalines; Receptors, Adrenergic, alpha; Tritium | 1991 |
The imidazoline-guanidinium receptor site, a target for some alpha-2 adrenergic agonists, is involved in inhibition of Na(+)-H+ exchange in renal proximal tubule cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Carrier Proteins; Dioxanes; Hydrogen; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ion Exchange; Kidney Tubules, Proximal; Oxazoles; Quinoxalines; Rabbits; Receptors, Drug; Rilmenidine; Sodium; Sodium-Hydrogen Exchangers | 1991 |
Interaction between norepinephrine and serotonin in the neuroendocrine control of growth hormone release in the rat.
Topics: 5,7-Dihydroxytryptamine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Cyproheptadine; Fenclonine; Growth Hormone; Growth Hormone-Releasing Hormone; Hydroxyindoleacetic Acid; Hypothalamus; Male; Metergoline; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin; Serotonin Antagonists | 1990 |
Inhibition of cAMP production by alpha 2-adrenoceptor stimulation in rabbit retina.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; GTP-Binding Proteins; In Vitro Techniques; Pertussis Toxin; Phosphoric Diester Hydrolases; Quinoxalines; Rabbits; Retina; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1991 |
Exercise training and responsiveness of isolated coronary arteries.
Topics: Animals; Brimonidine Tartrate; Coronary Vessels; Dogs; In Vitro Techniques; Isoproterenol; Male; Norepinephrine; Phenylephrine; Physical Conditioning, Animal; Physical Exertion; Quinoxalines; Substance P; Vasodilation | 1991 |
Agonist-dependent, cholera toxin-catalyzed ADP-ribosylation of pertussis toxin-sensitive G-proteins following transfection of the human alpha 2-C10 adrenergic receptor into rat 1 fibroblasts. Evidence for the direct interaction of a single receptor with t
Topics: Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Blood Platelets; Brimonidine Tartrate; Catalysis; Cholera Toxin; DNA; Fibroblasts; Gene Expression Regulation; GTP-Binding Proteins; Humans; Molecular Sequence Data; Pertussis Toxin; Precipitin Tests; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Transfection; Virulence Factors, Bordetella | 1991 |
Pertussis toxin reduces endothelium-dependent and independent responses to alpha-2- adrenergic stimulation in systemic canine arteries and veins.
Topics: Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Femoral Vein; In Vitro Techniques; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; Stimulation, Chemical; Vasoconstriction; Vasodilation; Virulence Factors, Bordetella | 1991 |
Specific decrease of high-affinity agonist states of alpha 2-adrenoceptors in the aging mouse brain.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; Female; Mice; Quinoxalines; Receptors, Adrenergic, alpha | 1990 |
Alpha 2-adrenoceptor-mediated inhibition of platelet adenylate cyclase and induction of aggregation in major depression. Effect of long-term cyclic antidepressant drug treatment.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Adult; Aged; Antidepressive Agents, Tricyclic; Blood Platelets; Brimonidine Tartrate; Colforsin; Depressive Disorder; Epinephrine; Female; Humans; Male; Middle Aged; Platelet Aggregation; Quinoxalines; Receptors, Adrenergic, alpha | 1990 |
Interaction between neuropeptide Y and noradrenaline on central catecholamine neurons.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; In Vitro Techniques; Locus Coeruleus; Neuropeptide Y; Norepinephrine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Opioid; Receptors, Opioid, mu; Thionucleotides; Yohimbine | 1990 |
Changes in intracellular free Ca2+ concentration by activation of alpha-adrenoceptors in rat tail artery.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Benzofurans; Brimonidine Tartrate; Calcium; Fura-2; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Regional Blood Flow; Tail; Vasoconstriction | 1990 |
Cochlear microcirculation. Effect of adrenergic agonists on arteriole diameter.
Topics: Adrenergic alpha-Agonists; Animals; Arterioles; Brimonidine Tartrate; Cochlea; Gerbillinae; Image Processing, Computer-Assisted; Microscopy, Fluorescence; Norepinephrine; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Videotape Recording | 1990 |
Electrophysiological analysis of adrenergic neurotransmission and its modulation by chronic denervation in canine saphenous veins.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Electric Stimulation; Electrophysiology; Female; Membrane Potentials; Muscle Denervation; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Prazosin; Quinoxalines; Saphenous Vein; Synaptic Transmission | 1990 |
Hamster adipocyte alpha 2-adrenoceptor changes during fat mass modifications are not directly dependent on adipose tissue norepinephrine content.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cricetinae; Dioxanes; Energy Intake; Food Deprivation; Hydroxydopamines; Idazoxan; Lipolysis; Male; Mesocricetus; Norepinephrine; Oxidopamine; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha; Sympathectomy, Chemical | 1990 |
Evidence against the "spare" receptor nature of alpha 2-adrenoceptors in hamster white fat cells.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Cell Membrane; Cricetinae; Cyclic AMP; Cystamine; Kinetics; Male; Mesocricetus; Quinoxalines; Receptors, Adrenergic, alpha | 1990 |
Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Binding Sites; Brimonidine Tartrate; Cell Membrane; Cystamine; Dioxanes; Dioxins; Epinephrine; Female; Humans; Idazoxan; Magnesium Chloride; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Tritium; Yohimbine | 1990 |
Discrimination between alpha 2-adrenoceptors and [3H]idazoxan-labelled non-adrenergic sites in rabbit white fat cells.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Dioxanes; Dioxins; Epinephrine; Idazoxan; In Vitro Techniques; Kinetics; Lipolysis; Male; Quinoxalines; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug; Structure-Activity Relationship | 1990 |
[Pharmacological studies of celiprolol: II. Alpha 2-Adrenoceptor blocking effects of a cardioselective beta-blocker, celiprolol].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Arteries; Blood Pressure; Brimonidine Tartrate; Celiprolol; In Vitro Techniques; Male; Muscle Contraction; Propanolamines; Quinoxalines; Rats; Rats, Inbred Strains; Tail; Tetrodotoxin; Vas Deferens; Vasoconstriction; Yohimbine | 1990 |
Selective reduction of alpha 2-adrenergic responsiveness in hamster adipose tissue during prolonged starvation.
Topics: Adenosine Deaminase; Adipose Tissue; Adrenergic beta-Agonists; Alprostadil; Animals; Blood Proteins; Brimonidine Tartrate; Cells, Cultured; Clonidine; Cricetinae; Fatty Acids, Nonesterified; Lipolysis; Male; Mesocricetus; Phenylisopropyladenosine; Quinoxalines; Receptors, Adrenergic, beta; Reference Values; Starvation | 1990 |
Decreased high affinity state in platelet alpha 2-adrenoceptors from diabetic patients with orthostatic hypotension.
Topics: Adrenergic alpha-Agonists; Adult; Blood Platelets; Brimonidine Tartrate; Cell Membrane; Diabetes Mellitus; Diabetic Neuropathies; Female; Glycated Hemoglobin; Humans; Hypotension, Orthostatic; Kinetics; Male; Middle Aged; Pressoreceptors; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Non-adrenergic sites for imidazolines are not directly involved in the alpha 2-adrenergic antilipolytic effect of UK 14304 in rat adipocytes.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Bucladesine; Cell Membrane; Colforsin; Dioxanes; Idazoxan; Kinetics; Lipolysis; Phentolamine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Photoperiodic control of adipocyte alpha 2-adrenoceptors in Syrian hamsters: role of testosterone.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Cricetinae; Dioxanes; Idazoxan; Isoproterenol; Kidney; Light; Lipolysis; Male; Mesocricetus; Periodicity; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha; Testosterone | 1990 |
Involvement of alpha-2 adrenergic receptor subtypes in hyperglycemia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Dioxanes; Dioxins; Drug Interactions; Hyperglycemia; Idazoxan; Imidazoles; Insulin; Male; Mice; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha | 1990 |
Pharmacological characterization of alpha-2 adrenergic receptor subtype involved in the release of insulin from isolated rat pancreatic islets.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Drug Interactions; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oxymetazoline; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
The role of alpha- and beta-adrenoceptor subtypes in mediating the effects of catecholamines on fasting glucose and insulin concentrations in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Catecholamines; Epinephrine; Insulin; Isoproterenol; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta | 1990 |
Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Oxymetazoline; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Pulse-to-pulse modulation of transmitter release in the central nervous system. Basic and pharmacological aspects.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Central Nervous System; Dopamine; Dopamine Antagonists; Homeostasis; Male; Norepinephrine; Quinolines; Quinoxalines; Rats; Rats, Inbred Strains; Tritium | 1990 |
Effects of light and an alpha-2-adrenergic agonist on serotonin N-acetyltransferase activity in chick pineal gland.
Topics: Adrenergic alpha-Agonists; Animals; Arylamine N-Acetyltransferase; Brimonidine Tartrate; Chickens; Circadian Rhythm; Melatonin; Photic Stimulation; Pineal Gland; Quinoxalines; Receptors, Adrenergic, alpha; Serotonin; Signal Transduction | 1990 |
Antinociceptive actions of alpha 2-adrenoceptor agonists in the rat spinal cord: evidence for antinociceptive alpha 2-adrenoceptor subtypes and dissociation of antinociceptive alpha 2-adrenoceptors from cyclic AMP.
Topics: Adrenergic alpha-Agonists; Animals; Benzylamines; Brimonidine Tartrate; Colforsin; Cyclic AMP; Guanfacine; Male; Neurotoxins; Nociceptors; Pain Measurement; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Spinal Cord; Yohimbine | 1990 |
Reduction of the N-type calcium current by noradrenaline in neurones of rabbit vesical parasympathetic ganglia.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Barium; Brimonidine Tartrate; Calcium Channels; Ganglia, Parasympathetic; In Vitro Techniques; Male; Membrane Potentials; Neurons; Norepinephrine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Time Factors; Yohimbine | 1990 |
The effectiveness of alpha 2-adrenoceptor activation increases from the distal to the proximal part of the veins of canine limbs.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Brimonidine Tartrate; Dogs; Extremities; Female; In Vitro Techniques; Male; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Saphenous Vein; Veins; Yohimbine | 1990 |
Effects of chronic norepinephrine administration on sympathetic neurotransmission in the isolated perfused rat kidney.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Drug Administration Schedule; Epinephrine; Injections, Subcutaneous; Kidney; Male; Neurotransmitter Agents; Norepinephrine; Perfusion; Phentolamine; Propranolol; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Sympathomimetics; Synaptic Transmission | 1990 |
The role of alpha 1-adrenoceptors in adrenaline-induced hyperkalaemia.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Epinephrine; Hyperkalemia; Pericardium; Phentolamine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Swine | 1990 |
Effects of the alpha 2-adrenoceptor agonist UK14304 on pressor responses in pithed rats.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Decerebrate State; Dose-Response Relationship, Drug; Drug Synergism; Norepinephrine; Phenylephrine; Prazosin; Pressoreceptors; Quinoxalines; Rats; Vasopressins; Yohimbine | 1990 |
Effect of CRL 41034 on the adrenergic neuroeffector interaction in the canine saphenous vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dogs; Electric Stimulation; Female; Isometric Contraction; Male; Norepinephrine; Phenylephrine; Piperidines; Pyrrolidines; Quinoxalines; Saphenous Vein | 1990 |
Autoradiographic localization of alpha 2-adrenoceptors in chick brain.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Brain; Brimonidine Tartrate; Chickens; Kinetics; Male; Organ Specificity; Quinoxalines; Receptors, Adrenergic, alpha; Tritium | 1990 |
Selective alpha 2-adrenoceptor blockade does not enhance glucose-evoked insulin release.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Dioxanes; Drug Interactions; Glucose; Idazoxan; Insulin; Male; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains | 1990 |
Corneal and conjunctival/scleral penetration of p-aminoclonidine, AGN 190342, and clonidine in rabbit eyes.
Topics: Absorption; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Chromatography, High Pressure Liquid; Clonidine; Conjunctiva; Cornea; Eye; Female; Perfusion; Permeability; Quinoxalines; Rabbits; Sclera; Solubility; Tissue Distribution | 1990 |
Ethnic differences in cyclic AMP accumulation: effect on alpha 2, beta 2, and prostanoid receptor responses.
Topics: Adult; Basal Metabolism; Black People; Blood Platelets; Brimonidine Tartrate; Cyclic AMP; Dinoprostone; Female; Humans; Isoproterenol; Lymphocytes; Male; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stimulation, Chemical; White People | 1990 |
Alpha 2-adrenoceptor antisecretory responses in the rat jejunum.
Topics: Animals; Body Fluids; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Electrolytes; Idazoxan; In Vitro Techniques; Jejunum; Male; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tetrodotoxin; Theophylline | 1990 |
Alpha-adrenoceptor reserve in the canine cephalic vein.
Topics: Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Female; Forelimb; Male; Phenoxybenzamine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Vasoconstriction; Veins; Yohimbine | 1990 |
Interaction between serotonin uptake inhibitors and alpha-2 adrenergic heteroreceptors in the rat hypothalamus.
Topics: Animals; Brimonidine Tartrate; Citalopram; Fenclonine; Hypothalamus; In Vitro Techniques; Male; Norepinephrine; Paroxetine; Piperidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Serotonin; Serotonin Antagonists | 1990 |
Desensitization of the alpha-2 adrenergic receptor in HT29 and opossum kidney cell lines.
Topics: Animals; Brimonidine Tartrate; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Humans; Norepinephrine; Opossums; Quinoxalines; Receptors, Adrenergic, alpha; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1990 |
Increased alpha 2-adrenergic binding sites and antilipolytic effect in adipocytes from genetically obese rats.
Topics: Adipose Tissue; Animals; Binding Sites; Brimonidine Tartrate; Dioxanes; Epinephrine; Idazoxan; Kinetics; Lipolysis; Male; Obesity; Propranolol; Quinoxalines; Rats; Rats, Zucker; Receptors, Adrenergic, alpha | 1990 |
Stimulation of alpha-adrenergic receptor augments the production of macrophage-derived tumor necrosis factor.
Topics: Animals; Base Sequence; Brimonidine Tartrate; Cell Line; Dose-Response Relationship, Drug; Female; Gene Expression; In Vitro Techniques; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred CBA; Molecular Sequence Data; Norepinephrine; Oligonucleotide Probes; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Tumor Necrosis Factor-alpha; Yohimbine | 1990 |
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.
Topics: Affinity Labels; Allosteric Regulation; Amino Acid Sequence; Animals; Aspartic Acid; Brimonidine Tartrate; Dioxanes; DNA Mutational Analysis; Epinephrine; Idazoxan; In Vitro Techniques; Molecular Sequence Data; Oxymetazoline; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Sodium; Structure-Activity Relationship; Swine; Transfection; Yohimbine | 1990 |
Functional evidence for heterogeneity of ocular alpha 2-adrenoceptors.
Topics: Anesthesia; Animals; Brimonidine Tartrate; Cats; Ciliary Body; Cyclic AMP; Dose-Response Relationship, Drug; Eye; Imidazoles; In Vitro Techniques; Iris; Isoproterenol; Medetomidine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Vasoactive Intestinal Peptide | 1990 |
Effects of pre-contraction with endothelin-1 on alpha 2-adrenoceptor- and (endothelium-dependent) neuropeptide Y-mediated contractions in the isolated vascular bed of the rat tail.
Topics: Animals; Blood Pressure; Brimonidine Tartrate; Cholic Acids; Endothelins; Endothelium, Vascular; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neuropeptide Y; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Regional Blood Flow; Tail; Yohimbine | 1990 |
Effect of imidazolines on Na+ transport and intracellular pH in renal proximal tubule cells.
Topics: Amiloride; Animals; Biological Transport; Brimonidine Tartrate; Cimetidine; Dioxanes; Dioxins; Hydrogen-Ion Concentration; Idazoxan; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sodium | 1990 |
Systemic and regional haemodynamic interactions between K+ channel openers and the sympathetic nervous system in the pithed SHR.
Topics: Animals; Benzopyrans; Brimonidine Tartrate; Cromakalim; Decerebrate State; Dihydropyridines; Heart Rate; Hemodynamics; Imidazoles; Male; Potassium Channels; Pyrroles; Quinoxalines; Rats; Rats, Inbred SHR; Regional Blood Flow; Sympathetic Nervous System; Vascular Resistance | 1990 |
In vivo and in vitro studies of alpha 2-adrenoceptor responses in human vascular smooth muscle.
Topics: Adult; Animals; Arm; Brimonidine Tartrate; Dioxanes; Dioxins; Doxazosin; Epinephrine; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Vasomotor System | 1985 |
Influence of nisoldipine on vascular resistance and vasoconstrictor responses in cats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Azepines; Blood Pressure; Brimonidine Tartrate; Cardiac Output; Cats; Dinoprost; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Methoxamine; Nifedipine; Nisoldipine; Norepinephrine; Phenylephrine; Prostaglandin Endoperoxides, Synthetic; Prostaglandins F; Quinoxalines; Splanchnic Circulation; Sulfonamides; Sympathetic Nervous System; Tyramine; Vascular Resistance; Vasoconstriction | 1987 |
Influence of androgenic status on the alpha 2/beta-adrenergic control of lipolysis in white fat cells: predominant alpha 2-antilipolytic response in testosterone-treated-castrated hamsters.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Animals; Brimonidine Tartrate; Clonidine; Colforsin; Cricetinae; Cyclic AMP; Epinephrine; Isoproterenol; Lipolysis; Male; Mesocricetus; Niacin; Orchiectomy; Phentolamine; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Testosterone | 1988 |
Alpha 2-adrenoceptor-mediated inhibition of histamine release from rat cerebral cortical slices.
Topics: Animals; Brimonidine Tartrate; Cerebral Cortex; Clonidine; Histamine Release; In Vitro Techniques; Male; Neurotransmitter Agents; Norepinephrine; Potassium; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1988 |
Ketanserin: systemic and regional hemodynamic characterization of its serotonergic and alpha-adrenergic receptor blocking effects in the pithed SHR.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Cardiac Output; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Ketanserin; Male; Quinoxalines; Rats; Rats, Inbred SHR; Regional Blood Flow; Serotonin Antagonists; Vascular Resistance | 1989 |
Neuropeptide Y and galanin in norepinephrine release in hypothalamic slices.
Topics: Adenylate Cyclase Toxin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Galanin; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Neuropeptide Y; Norepinephrine; Peptides; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1989 |
Vasoactive intestinal polypeptide and alpha 2-adrenoceptor agonists regulate adenosine 3',5'-monophosphate accumulation and melatonin release in chick pineal cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Brimonidine Tartrate; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Kinetics; Melatonin; Molecular Sequence Data; Pineal Gland; Quinoxalines; Radioimmunoassay; Sequence Homology, Nucleic Acid; Structure-Activity Relationship; Vasoactive Intestinal Peptide | 1989 |
Contractile properties of human prostate adenomas and the development of infravesical obstruction.
Topics: Aged; Brimonidine Tartrate; Carbachol; Humans; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Prostatic Hyperplasia; Quinoxalines; Sensory Receptor Cells; Urinary Bladder Neck Obstruction | 1989 |
Involvement of adenylate cyclase and protein kinase C in the alpha 2-adrenoceptor-mediated inhibition of noradrenaline and 5-hydroxytryptamine release in rat hypothalamic slices.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Antihypertensive Agents; Brimonidine Tartrate; Colforsin; Dioxanes; Electric Stimulation; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Serotonin | 1989 |
Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein.
Topics: Adenosine Diphosphate; Animals; Antihypertensive Agents; Blood Platelets; Bradykinin; Brimonidine Tartrate; Calcimycin; Coronary Vessels; Dinoprost; Endothelium, Vascular; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Pertussis Toxin; Potassium Chloride; Quinoxalines; Serotonin; Swine; Thrombin; Virulence Factors, Bordetella | 1989 |
Sympathetic vascular control of the pig nasal mucosa: adrenoceptor mechanisms in blood flow and volume control.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Desipramine; Dioxanes; Electric Stimulation; Female; Idazoxan; Male; Nasal Mucosa; Norepinephrine; Oxymetazoline; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic; Regional Blood Flow; Rheology; Swine; Sympathetic Nervous System | 1989 |
Alpha 2-adrenoceptors mediate inhibition of cyclic AMP production in the spinal cord after stimulation of cyclic AMP with forskolin but not after stimulation with capsaicin or vasoactive intestinal peptide.
Topics: Adenine; Animals; Brimonidine Tartrate; Capsaicin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Guinea Pigs; Male; Quinoxalines; Receptors, Adrenergic, alpha; Spinal Cord; Tissue Distribution; Vasoactive Intestinal Peptide | 1989 |
Characterization and regional distribution of alpha 2-adrenoceptors in postmortem human brain using the full agonist [3H]UK 14304.
Topics: Adult; Binding Sites; Binding, Competitive; Brain; Brimonidine Tartrate; Female; Humans; Male; Quinoxalines; Receptors, Adrenergic, alpha; Tissue Distribution; Tritium | 1989 |
Regional variation of postjunctional alpha-adrenoceptor responses in the developing renal vascular bed of sheep.
Topics: Age Factors; Animals; Animals, Newborn; Brimonidine Tartrate; Fetus; Guanabenz; Isometric Contraction; Kidney; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Renal Artery; Renal Veins; Sheep; Vasoconstriction | 1989 |
Inhibition of cholinergic and non-adrenergic, non-cholinergic bronchoconstriction in the guinea pig mediated by neuropeptide Y and alpha 2-adrenoceptors and opiate receptors.
Topics: Animals; Antihypertensive Agents; Autonomic Nervous System; Brimonidine Tartrate; Bronchi; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Morphine; Muscle, Smooth; Neuropeptide Y; Parasympathetic Nervous System; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid; Sympathomimetics | 1989 |
Postjunctional alpha 2-adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Arteries; Azepines; Brimonidine Tartrate; Doxazosin; Female; Humans; In Vitro Techniques; Male; Middle Aged; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Skin; Vascular Resistance; Vasoconstriction; Veins; Yohimbine | 1989 |
Coupling between hypothalamic alpha 2-adrenoceptors and [3H]mazindol binding site in response to several hyperglycaemic stimuli in mice.
Topics: Animals; Binding Sites; Brimonidine Tartrate; Dioxanes; Feeding Behavior; Hyperglycemia; Hypothalamus; Idazoxan; Indoles; Male; Mazindol; Mice; Quinoxalines; Receptors, Adrenergic, alpha | 1989 |
Alpha-2A and alpha-2B adrenergic receptor subtypes: attenuation of cyclic AMP production in cell lines containing only one receptor subtype.
Topics: Animals; Brimonidine Tartrate; Cyclic AMP; Humans; Isoquinolines; Piperazines; Prazosin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tumor Cells, Cultured; Yohimbine | 1989 |
Functional alpha 2-adrenoceptors in rat adipocytes: inhibition of cyclic AMP accumulation.
Topics: Adenylate Cyclase Toxin; Adipose Tissue; Animals; Brimonidine Tartrate; Clonidine; Colforsin; Cricetinae; Cyclic AMP; Male; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1989 |
The effects of acute and chronic desipramine on the thermogenic and hypoactivity responses to alpha 2-agonists in reserpinized and normal mice.
Topics: Adrenergic alpha-Agonists; Animals; Body Temperature Regulation; Brimonidine Tartrate; Clonidine; Desipramine; Female; Mice; Mice, Inbred Strains; Motor Activity; Norepinephrine; Quinoxalines; Reserpine | 1989 |
Expression of functional postjunctional alpha 2-adrenoceptors in rabbit isolated distal saphenous artery--a permissive role for angiotensin II?
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Arteries; Brimonidine Tartrate; Drug Interactions; In Vitro Techniques; Male; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine | 1989 |
Interactions of full and partial agonists with HT29 cell alpha 2-adrenoceptor: comparative study of [3H]UK-14,304 and [3H]clonidine binding.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Guanylyl Imidodiphosphate; Kinetics; Quinoxalines; Receptors, Adrenergic, alpha; Sodium; Tritium; Tumor Cells, Cultured; Vasoactive Intestinal Peptide; Yohimbine | 1989 |
Hypothermia induces supersensitivity of mouse vas deferens to adrenergic agonists: evidence for postjunctional alpha 2-adrenoceptors.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Hypothermia; In Vitro Techniques; Male; Methoxamine; Mice; Muscle, Smooth; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Sympathomimetics; Temperature; Vas Deferens | 1989 |
Single potassium channels opened by opioids in rat locus ceruleus neurons.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Brimonidine Tartrate; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Electric Conductivity; Endorphins; Enkephalin, Methionine; Locus Coeruleus; Membrane Potentials; Naloxone; Neurons; Potassium Channels; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, mu; Receptors, Somatostatin; Somatostatin | 1989 |
Human fat cell alpha-2 adrenoceptors. I. Functional exploration and pharmacological definition with selected alpha-2 agonists and antagonists.
Topics: Adenosine Deaminase; Adenylyl Cyclase Inhibitors; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Brimonidine Tartrate; Cystamine; Female; Guanosine Triphosphate; Humans; Lipolysis; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Human fat cell alpha-2 adrenoceptors. II. Comparative study of partial and full agonist binding parameters using [3H]clonidine and [3H]UK-14,304.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Allosteric Regulation; Binding, Competitive; Brimonidine Tartrate; Clonidine; Ethylmaleimide; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; In Vitro Techniques; Kinetics; Magnesium; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Alpha 2-adrenoceptor agonist-mediated inhibition of [3H]noradrenaline release from rat hippocampus is reduced by 4-aminopyridine, but that caused by an adenosine analogue or omega-conotoxin is not.
Topics: 4-Aminopyridine; Adenosine; Adrenergic alpha-Agonists; Aminopyridines; Animals; Brimonidine Tartrate; Cadmium; Cadmium Chloride; Conotoxins; Hippocampus; Male; Mollusk Venoms; Norepinephrine; Phenylisopropyladenosine; Quinoxalines; Rats; Rats, Inbred Strains; Yohimbine | 1989 |
Dopamine receptors in the stellate ganglion of the dog.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Dopamine Agents; Electric Stimulation; Heart Rate; In Vitro Techniques; Injections, Intravenous; Male; Quinoxalines; Receptors, Dopamine; Stellate Ganglion | 1989 |
The effect of UK14,304-18 (an alpha-2 adrenergic agonist) on myocardial blood flow during cardiopulmonary resuscitation.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Coronary Circulation; Hemodynamics; Quinoxalines; Resuscitation; Swine | 1989 |
Alpha-adrenoceptors and insulin release from pancreatic islets of normal and diabetic rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Diabetes Mellitus, Experimental; Dioxanes; Female; Glucose; Idazoxan; Insulin; Islets of Langerhans; Male; Phentolamine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Streptozocin; Yohimbine | 1989 |
Alpha 2-adrenoceptor agonists enhance vasoconstrictor responses to alpha 1-adrenoceptor agonists in the rat tail artery by increasing the influx of Ca2+.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Calcium; Diltiazem; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Perfusion; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Regional Blood Flow; Tail; Tetrahydronaphthalenes; Vasoconstriction | 1989 |
Platelet aggregation induced by alpha 2-adrenoceptor and protein kinase C activation. A novel synergism.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Adrenergic alpha-Agonists; Blood Platelets; Brimonidine Tartrate; Calcium; Diglycerides; Drug Synergism; Enzyme Activation; Epinephrine; GTP-Binding Proteins; Humans; Immunosorbent Techniques; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Phosphorylation; Platelet Aggregation; Protein Kinase C; Quinoxalines; Receptors, Adrenergic, alpha; Type C Phospholipases; Virulence Factors, Bordetella | 1989 |
DTG and (+)-3-PPP inhibit a ligand-activated hyperpolarization in mammalian neurons.
Topics: Animals; Brimonidine Tartrate; Dopamine Agents; Enkephalin, Methionine; Guanidines; Haloperidol; Male; Membrane Potentials; Neurons; Norepinephrine; Piperidines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Serotonin | 1989 |
The paradox of alpha 2 adrenergic regulation of prolactin (PRL) secretion. I. The PRL-releasing action of the alpha 2 receptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Growth Hormone; Injections, Intravenous; Male; Nervous System; Prolactin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1989 |
Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cricetinae; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipolysis; Male; Mesocricetus; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Can UK-14, 304-18 lower IOP in rabbits by a peripheral mechanism?
Topics: Administration, Topical; Animals; Anterior Chamber; Blood Pressure; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Administration Routes; Female; Ganglia, Sympathetic; Ganglionectomy; Heart Rate; Injections; Intraocular Pressure; Male; Pupil; Quinoxalines; Rabbits | 1989 |
Pertussis toxin inhibits endothelium-dependent relaxations to certain agonists in porcine coronary arteries.
Topics: Adenylate Cyclase Toxin; Animals; Brimonidine Tartrate; Coronary Vessels; Endothelium, Vascular; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Oxyhemoglobins; Pertussis Toxin; Platelet Aggregation; Quinoxalines; Serotonin; Swine; Thrombin; Virulence Factors, Bordetella | 1989 |
Characterization of dog fat cell adrenoceptors: variations in alpha-2 and beta adrenergic receptors distribution according to the extent of the fat deposits and the anatomical location.
Topics: Adipose Tissue; Animals; Binding, Competitive; Brimonidine Tartrate; Clonidine; Cyclic AMP; Dihydroalprenolol; Dogs; Epinephrine; Humans; Isoproterenol; Lipolysis; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yohimbine | 1987 |
Effects of triiodo-L-thyronine (T3)-induced hyperthyroidism on the cardiovascular alpha-adrenoceptor system in young and older rats.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cardiovascular System; Decerebrate State; Hyperthyroidism; Male; Myocardium; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Triiodothyronine | 1987 |
Characterization of alpha-adrenoceptors on isolated rabbit renal arterioles.
Topics: Animals; Arterioles; Brimonidine Tartrate; Dose-Response Relationship, Drug; Imidazoles; Kidney Cortex; Male; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction | 1988 |
Uncoupling of the platelet alpha 2-adrenoceptor adenylate cyclase system by N-ethylmaleimide and the resulting effect on receptor density and sensitivity.
Topics: Adenylyl Cyclases; Adult; Antihypertensive Agents; Blood Platelets; Brimonidine Tartrate; Colforsin; Ethylmaleimide; Humans; In Vitro Techniques; Kinetics; Male; Quinoxalines; Receptors, Adrenergic, alpha; Sulfhydryl Reagents | 1988 |
Cooling the central ear artery of the rabbit: myogenic and adrenergic responses.
Topics: Adenosine Triphosphate; Animals; Arteries; Brimonidine Tartrate; Calcium; Cold Temperature; Ear; Electric Stimulation; Indomethacin; Male; Norepinephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Tetrodotoxin; Vasoconstriction; Yohimbine | 1988 |
Mechanism of agonist and antagonist binding to alpha 2 adrenergic receptors: evidence for a precoupled receptor-guanine nucleotide protein complex.
Topics: Antihypertensive Agents; Blood Platelets; Brimonidine Tartrate; Cell Membrane; GTP-Binding Proteins; Humans; Kinetics; Mathematics; Models, Biological; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1988 |
Temperature effects on alpha 2-adrenergic receptor-Gi interactions.
Topics: Adenylyl Cyclase Inhibitors; Brimonidine Tartrate; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; In Vitro Techniques; Kinetics; Quinoxalines; Receptors, Adrenergic, alpha; Temperature; Yohimbine | 1988 |
Alpha 2-receptors mediate catecholamine-stimulated acid secretion in Amphiuma jejunum.
Topics: Animals; Brimonidine Tartrate; Clonidine; In Vitro Techniques; Jejunum; Methoxamine; Norepinephrine; Phenylephrine; Propranolol; Protons; Quinoxalines; Receptors, Adrenergic, alpha; Stimulation, Chemical; Urodela | 1988 |
A comparison of the actions of noradrenaline and UK-14,304 in the longitudinal smooth muscle of the rat isolated portal vein--no evidence for a population of post-junctional alpha 2-adrenoceptors.
Topics: Animals; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1988 |
Alpha 2-adrenoceptors in human forebrain: autoradiographic visualization and biochemical parameters using the agonist [3H]UK-14304.
Topics: Aged; Animals; Autoradiography; Brimonidine Tartrate; Female; Frontal Lobe; Humans; Kinetics; Male; Middle Aged; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1988 |
Norepinephrine inhibits calcium action potential through alpha 2-adrenoceptors in rabbit vesical parasympathetic neurons.
Topics: Action Potentials; Animals; Brimonidine Tartrate; Calcium; Clonidine; Ganglia, Parasympathetic; Male; Norepinephrine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Urinary Bladder; Yohimbine | 1988 |
An examination of the postjunctional alpha-adrenoceptor subtypes for (-)-noradrenaline in several isolated blood vessels from the rabbit.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Brimonidine Tartrate; Ear; Female; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Renal Veins; Saphenous Vein; Stereoisomerism; Yohimbine | 1988 |
Alpha-1- and alpha-2-noradrenergic receptors modulate lordosis behavior in female guinea pigs.
Topics: Animals; Brimonidine Tartrate; Female; Guinea Pigs; Methoxamine; Ovariectomy; Phenylephrine; Quinoxalines; Receptors, Adrenergic; Sexual Behavior, Animal | 1988 |
Effects of desipramine on stimulation-induced contractions of the vas deferens of rats pretreated either chronically with desipramine or acutely with idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Desipramine; Dioxanes; Dioxins; Drug Interactions; Electric Stimulation; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors; Vas Deferens | 1985 |
Pharmacological characterization of postsynaptic alpha-adrenoceptor subtypes in five different dog arteries in-vitro.
Topics: Animals; Antihypertensive Agents; Arteries; Brimonidine Tartrate; Cocaine; Dogs; In Vitro Techniques; Muscle, Smooth, Vascular; Phenylephrine; Prazosin; Propiophenones; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Neurotransmitter; Yohimbine | 1985 |
Studies on YM-12617: a selective and potent antagonist of postsynaptic alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Blood Pressure; Brain; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Phenylephrine; Pulmonary Artery; Quinoxalines; Rabbits; Rats; Receptors, Adrenergic, alpha; Sulfonamides; Tritium; Vas Deferens | 1985 |
The role of alpha-adrenoceptors in the regulation of renal tubular sodium reabsorption and renin secretion in the rabbit.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Guanabenz; Hemodynamics; Idazoxan; Kidney; Kidney Tubules; Male; Methoxamine; Natriuresis; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Renin; Sodium | 1985 |
Interactions of dimethoxy-substituted tolazoline derivatives with alpha 1- and alpha 2-adrenoreceptors in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aorta; Brain; Brimonidine Tartrate; Clonidine; Dioxanes; Electric Stimulation; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle, Smooth; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tolazoline | 1985 |
A difference in the affinity of some selective alpha 2-adrenoceptor antagonists when compared on isolated vasa deferentia of rat and rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Quinoxalines; Rabbits; Rats; Vas Deferens | 1985 |
Evidence for existence of postjunctional alpha 1- and alpha 2-adrenoceptors in cat pulmonary vascular bed.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Cats; Female; Male; Methoxamine; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine | 1985 |
Alpha 2-adrenergic receptors in the human cell line, HT29. Characterization with the full agonist radioligand [3H]UK-14,304 and inhibition of adenylate cyclase.
Topics: Adenocarcinoma; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Brimonidine Tartrate; Cell Line; Clonidine; Colforsin; Colonic Neoplasms; Dose-Response Relationship, Drug; Guanosine Triphosphate; Humans; Kinetics; Magnesium; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Vasoactive Intestinal Peptide; Yohimbine | 1985 |
Agonist and antagonist binding to alpha 2-adrenergic receptors in purified membranes from human platelets. Implications of receptor-inhibitory nucleotide-binding protein stoichiometry.
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Platelets; Brimonidine Tartrate; Clonidine; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; In Vitro Techniques; NAD; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1985 |
Relative contribution of different vascular beds to the pressor effects of alpha-adrenoreceptor agonists and vasopressin in pithed rats: radioactive microsphere determination.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Chromium Radioisotopes; Decerebrate State; Male; Methoxamine; Microspheres; Quinoxalines; Rats; Rats, Inbred Strains; Vasoconstriction; Vasopressins | 1985 |
Neural control of jejunal and ileal motility and transmural potential difference in the ferret.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Atropine; Brimonidine Tartrate; Dioxanes; Ferrets; Gastrointestinal Motility; Idazoxan; Ileum; In Vitro Techniques; Jejunum; Male; Membrane Potentials; Muscle Contraction; Quinoxalines | 1986 |
Enhancement of alpha- and beta-adrenoceptor responses by elevations in vascular tone in pulmonary circulation.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Cats; Female; Male; Muscle Tonus; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Propanolamines; Pulmonary Circulation; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yohimbine | 1986 |
Characterization of alpha-adrenoceptors in the vasculature of the canine nasal mucosa.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Female; Male; Nasal Mucosa; Norepinephrine; Phosphodiesterase Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Sympathetic Nervous System | 1986 |
Heterogeneity between soluble human and rabbit splenic alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; Lectins; Oxymetazoline; Phentolamine; Prazosin; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Solubility; Spleen; Sulfhydryl Reagents; Yohimbine | 1986 |
Ocular effects of a relatively selective alpha 2 agonist (UK-14, 304-18) in cats, rabbits and monkeys.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cats; Cebus; Eye; Female; Intraocular Pressure; Male; Neurons; Ocular Hypertension; Pupil; Quinoxalines; Rabbits; Water | 1986 |
Postsynaptic alpha 1- and alpha 2-adrenergic receptors in adrenergic control of capacitance vessel tone in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Blood Volume; Brimonidine Tartrate; Compliance; Dogs; Female; Male; Methoxamine; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Splanchnic Circulation; Splenectomy; Tyramine; Vasoconstriction; Yohimbine | 1986 |
The effect of alpha 2-adrenoceptor agonists on the acid secretory responses of rat isolated gastric mucosa to electrical field stimulation.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Gastric Acid; Gastric Mucosa; Histamine; Idazoxan; In Vitro Techniques; Male; Pentagastrin; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains | 1986 |
Alpha 2-adrenergic receptor turnover in adipose tissue and kidney: irreversible blockade of alpha 2-adrenergic receptors by benextramine.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Clonidine; Cricetinae; Cystamine; Dose-Response Relationship, Drug; Kidney; Lipid Mobilization; Male; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1987 |
Evidence for a receptor mediated action of norepinephrine distinct from alpha- and beta-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cystamine; Guinea Pigs; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Quinoxalines; Receptors, Adrenergic | 1986 |
Alpha 2-adrenergic receptor-mediated sensitization of forskolin-stimulated cyclic AMP production.
Topics: Adenine; Adenocarcinoma; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Cell Line; Colforsin; Colonic Neoplasms; Cyclic AMP; Humans; Kinetics; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha | 1987 |
In vivo assessment of rat renal alpha adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Brimonidine Tartrate; Dose-Response Relationship, Drug; Guanabenz; Homeostasis; Imidazoles; Kidney; Male; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Ultrasonography; Vasoconstriction | 1987 |
Pharmacological characterization of the postsynaptic alpha-adrenoceptors in isolated canine mesenteric arteries and veins.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Dopamine; Female; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Synapses; Yohimbine | 1987 |
Characterization of the alpha-adrenoceptors mediating positive inotropy of rat left atria by use of selective agonists and antagonists.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Muscle Contraction; Myocardial Contraction; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical | 1987 |
In vivo or in vitro exposure to imipramine reduces alpha 2-adrenoceptor-mediated inhibition of cyclic AMP production in rat brain cerebral cortical slices.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cerebral Cortex; Colforsin; Cyclic AMP; Drug Interactions; Imipramine; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1987 |
The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine.
Topics: Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Dioxanes; Dogs; Idazoxan; In Vitro Techniques; Male; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Quinoxalines; Saphenous Vein | 1987 |
Tight agonist binding may prevent the correct interpretation of agonist competition binding curves for alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cell Membrane; Clonidine; Dioxanes; Epinephrine; Idazoxan; Kinetics; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Retina | 1987 |
Alpha 2-adrenoceptor-mediated responses to so-called selective alpha 1-adrenoceptor agonists after partial blockade of alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dogs; Drug Interactions; In Vitro Techniques; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Phenoxybenzamine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1987 |
Agonist binding at alpha 2-adrenoceptors of human platelets using 3H-UK-14,304: regulation by Gpp(NH)p and cations.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Antihypertensive Agents; Binding, Competitive; Blood Platelets; Brimonidine Tartrate; Cations; Cell Membrane; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; In Vitro Techniques; Kinetics; Ligands; Magnesium; Magnesium Chloride; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1987 |
Evidence that 8-hydroxy-2-(n-dipropylamino)tetralin (8-OH-DPAT) is a selective alpha 2-adrenoceptor antagonist on guinea-pig submucous neurones.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Naphthalenes; Neurons; Quinoxalines; Synapses; Tetrahydronaphthalenes | 1987 |
Endothelium-dependent responses in autogenous femoral veins grafted into the arterial circulation of the dog.
Topics: Acetylcholine; Adenosine Diphosphate; Adrenergic alpha-Agonists; Animals; Arachidonic Acid; Arachidonic Acids; Arteries; Brimonidine Tartrate; Calcimycin; Dogs; Endothelium; Femoral Vein; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Quinoxalines; Thrombin | 1987 |
The effect of neuropeptide Y (NPY) on stimulation-evoked release of [3H]norepinephrine (NE) from rat hypothalamic and cerebral cortical slices.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Hypothalamus; Idazoxan; In Vitro Techniques; Male; Neuropeptide Y; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1987 |
Inhibitory effects of diltiazem on vasoconstrictor responses in the cat.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Brimonidine Tartrate; Cats; Diltiazem; Electric Stimulation; Female; Male; Methoxamine; Norepinephrine; Phenylephrine; Potassium Chloride; Quinoxalines; Tyramine; Vasoconstriction | 1988 |
Characterization of alpha-2 adrenergic receptors in the OK cell, an opossum kidney cell line.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Line; Cyclic AMP; Kidney; Kinetics; Opossums; Parathyroid Hormone; Quinoxalines; Receptors, Adrenergic, alpha; Yohimbine | 1988 |
Direct effects of alpha 2-adrenergic receptor stimulation on intravascular systemic capacity in the dog.
Topics: Adrenergic alpha-Agonists; Animals; Azepines; Blood Volume; Brimonidine Tartrate; Cardiopulmonary Bypass; Central Venous Pressure; Dogs; Hepatic Veins; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Tachyphylaxis; Vascular Resistance; Yohimbine | 1988 |
Identification of alpha 2-adrenergic receptors in chicken pineal gland using [3H]rauwolscine.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Membrane; Chickens; Circadian Rhythm; Female; Isoquinolines; Male; Pindolol; Pineal Gland; Piperazines; Quinoxalines; Receptors, Adrenergic, alpha; Tritium; Yohimbine | 1988 |
Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brain; Brimonidine Tartrate; Clonidine; Female; Imidazoles; In Vitro Techniques; Male; Medetomidine; Muscle, Smooth; Mydriatics; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1988 |
Mechanism of synaptic inhibition by noradrenaline acting at alpha 2-adrenoceptors.
Topics: Algorithms; Animals; Brimonidine Tartrate; Clonidine; Electric Conductivity; Guinea Pigs; Membrane Potentials; Norepinephrine; Potassium; Quinoxalines; Receptors, Adrenergic, alpha; Synapses | 1988 |
Pharmacological characterization of the hyperglycemia induced by alpha-2 adrenoceptor agonists.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; alpha-Methyltyrosine; Animals; Benzylamines; Blood Glucose; Brimonidine Tartrate; Diabetes Mellitus, Experimental; Hyperglycemia; Insulin; Male; Methyltyrosines; Mice; Quinoxalines; Reserpine | 1988 |
Evidence of functional alpha 2-adrenergic receptors in adult-rat adipocytes by using the agonist UK 14304.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Age Factors; Animals; Brimonidine Tartrate; Cell Membrane; Clonidine; Epinephrine; In Vitro Techniques; Lipolysis; Male; Quinoxalines; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Adrenergic, alpha; Theophylline | 1988 |
Pharmacologic characterization of SK&F 104078, a novel alpha-2 adrenoceptor antagonist which discriminates between pre- and postjunctional alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Dogs; Guinea Pigs; Male; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Serotonin; Synaptic Transmission; Vasoconstriction | 1988 |
Inhibition of cyclic AMP production by alpha 2-adrenoceptor stimulation in the guinea-pig spinal cord slices.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Colforsin; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Male; Prazosin; Quinoxalines; Spinal Cord; Yohimbine | 1988 |
Loss of selectivity of so-called selective alpha 1-adrenoceptor agonists after phenoxybenzamine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Female; Imidazoles; Male; Phenoxybenzamine; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1988 |
Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Cerebral Cortex; Guanosine Triphosphate; Humans; Kinetics; Quinoxalines; Receptors, Adrenergic, alpha | 1988 |
Inhibition of adenylate cyclase is mediated by the high affinity conformation of the alpha 2-adrenergic receptor.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Blood Platelets; Brimonidine Tartrate; GTP-Binding Proteins; Guanosine Triphosphate; Humans; In Vitro Techniques; Kinetics; Models, Biological; Protein Conformation; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha | 1988 |
Evidence that the population of postjunctional-adrenoceptors mediating contraction of smooth muscle in the rabbit isolated ear vein is predominantly alpha 2.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Veins; Yohimbine | 1988 |
Adrenergic-induced hyperglycemia in anaesthetized rats: involvement of peripheral alpha 2-adrenoceptors.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Glucose; Brimonidine Tartrate; Diabetes Mellitus, Experimental; Epinephrine; Ganglionic Blockers; Male; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Sympatholytics | 1988 |
Microvascular effects of atrial natriuretic factor: interaction with alpha 1- and alpha 2-adrenoceptors.
Topics: Animals; Arterioles; Atrial Natriuretic Factor; Brimonidine Tartrate; Microcirculation; Norepinephrine; Osmolar Concentration; Phenylephrine; Quinoxalines; Vasoconstriction; Vasodilation; Venules | 1988 |
Size and site-dependent heterogeneity of human vascular responses in vitro.
Topics: Arteries; Atrial Natriuretic Factor; Azepines; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Neuropeptide Y; Neuropeptides; Phenylephrine; Quinoxalines; Vascular Resistance; Vasoactive Intestinal Peptide | 1988 |
Evaluation of the alpha-1 and alpha-2 adrenoceptor-mediated effects of a series of dimethoxy-substituted tolazoline derivatives in the cardiovascular system of the pithed rat.
Topics: Animals; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Male; Prazosin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Spinal Cord; Tolazoline; Yohimbine | 1985 |
Endothelial alpha 2-adrenoceptors in canine pulmonary and systemic blood vessels.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Endothelium; Female; In Vitro Techniques; Isometric Contraction; Lung; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Pulmonary Artery; Pulmonary Veins; Quinoxalines; Receptors, Adrenergic, alpha | 1985 |
Alpha-1 and alpha-2 adrenoceptor: response coupling in canine saphenous and femoral veins.
Topics: Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Female; Femoral Vein; Imidazoles; Male; Mathematics; Norepinephrine; Phenoxybenzamine; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein | 1986 |
Effect of cooling on alpha-1 and alpha-2 adrenergic responses in canine saphenous and femoral veins.
Topics: Animals; Azepines; Brimonidine Tartrate; Cold Temperature; Dogs; Female; Femoral Vein; Isometric Contraction; Male; Mathematics; Norepinephrine; Phenoxybenzamine; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein; Time Factors | 1986 |
Nature of alpha 1 and postjunctional alpha 2 adrenoceptors in the pulmonary vascular bed.
Topics: Animals; Azepines; Blood Pressure; Brimonidine Tartrate; Cats; Hydroxydopamines; Methoxamine; Norepinephrine; Oxidopamine; Phenylephrine; Prazosin; Propranolol; Pulmonary Artery; Quinoxalines; Receptors, Adrenergic, alpha; Vasoconstriction; Yohimbine | 1986 |
A study on the postjunctional excitatory alpha-adrenoreceptor subtypes in the mesenteric arterial bed of the rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; In Vitro Techniques; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Time Factors; Yohimbine | 1986 |
Platelet high affinity adrenoceptor binding sites labelled with the agonist [3H]UK-14,304, in depressed patients and matched controls.
Topics: Adult; Blood Platelets; Brimonidine Tartrate; Clonidine; Depression; Female; Humans; Kinetics; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha | 1986 |
A procedure for measuring alpha 2-adrenergic receptor-mediated inhibition of cyclic AMP accumulation in rat brain slices.
Topics: 2-Chloroadenosine; Adenosine; Animals; Brain; Brimonidine Tartrate; Colforsin; Cyclic AMP; In Vitro Techniques; Isoproterenol; Male; Mianserin; Norepinephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasoactive Intestinal Peptide | 1986 |
Alpha-2-adrenergic control of prolactin release.
Topics: Animals; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Female; Male; Piperoxan; Pregnancy; Prolactin; Quinolizines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1986 |
Alpha adrenergic responses of blood vessels of rabbits after ovariectomy and administration of 17 beta-estradiol.
Topics: Animals; Blood Vessels; Brimonidine Tartrate; Estradiol; Female; Muscle, Smooth, Vascular; Norepinephrine; Ovariectomy; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction; Vasomotor System; Yohimbine | 1987 |
Receptor reserve at the alpha-2 adrenergic receptor in the rat cerebral cortex.
Topics: Animals; Brimonidine Tartrate; Cerebral Cortex; In Vitro Techniques; Male; Norepinephrine; Quinolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Secretory Rate; Time Factors | 1987 |
Denervation augments alpha-2 but not alpha-1 adrenergic responses in canine saphenous veins.
Topics: Animals; Brimonidine Tartrate; Denervation; Dogs; Norepinephrine; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein; Sympathetic Nervous System; Tyramine; Vasoconstriction; Vasomotor System | 1987 |
Influence of the vascular endothelium on agonist-induced contractions and relaxations in rat aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Brimonidine Tartrate; Cyclic GMP; Endothelium; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Rats; Rats, Inbred Strains | 1986 |
Hormonal control of fructose 2,6-bisphosphate concentration in the HT29 human colon adenocarcinoma cell line. Alpha 2-adrenergic agonists counteract effect of vasoactive intestinal peptide.
Topics: Adenocarcinoma; Brimonidine Tartrate; Cell Line; Clonidine; Colonic Neoplasms; Cyclic AMP; Epinephrine; Fructosediphosphates; Hexosediphosphates; Humans; Quinoxalines; Vasoactive Intestinal Peptide; Yohimbine | 1986 |
[3H] UK-14,304, a new agonist ligand of alpha 2-adrenoceptors: a comparative study with human and rat tissue.
Topics: Adult; Animals; Binding, Competitive; Blood Platelets; Brimonidine Tartrate; Cerebral Cortex; Clonidine; Humans; Kinetics; Ligands; Middle Aged; Psychotropic Drugs; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1987 |
Platelet alpha 2-adrenoceptor binding and function during the menstrual cycle.
Topics: Adolescent; Adult; Blood Platelets; Brimonidine Tartrate; Estradiol; Female; Humans; Kinetics; Menstrual Cycle; Platelet Aggregation; Progesterone; Quinoxalines; Receptors, Adrenergic, alpha | 1987 |
Compartmentation of alpha 2-adrenergic receptors in human erythroleukemia (HEL) cells.
Topics: Adenylyl Cyclases; Brimonidine Tartrate; Cell Compartmentation; Cell Membrane; Cyclic AMP; Epinephrine; GTP-Binding Proteins; Humans; Leukemia, Erythroblastic, Acute; Quinoxalines; Receptors, Adrenergic, alpha; Temperature; Yohimbine | 1987 |
Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.
Topics: Amiloride; Animals; Brain Chemistry; Brimonidine Tartrate; Carrier Proteins; Cerebral Cortex; Epinephrine; Hydrogen; Hydrogen-Ion Concentration; Quinoxalines; Receptors, Adrenergic, alpha; Sodium; Sodium-Hydrogen Exchangers; Swine; Yohimbine | 1987 |
Beta-endorphin: a common factor in the antihypertensive action of clonidine-type imidazolines in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; beta-Endorphin; Blood Pressure; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Endorphins; Hypertension; Imidazoles; Injections, Intraventricular; Male; Quinoxalines; Rats | 1985 |
Omega-conotoxin GVIA and pharmacological modulation of hippocampal noradrenaline release.
Topics: Aminopyridines; Animals; Brimonidine Tartrate; Cadmium; Calcium Channel Blockers; Dioxanes; Hippocampus; Idazoxan; In Vitro Techniques; Mollusk Venoms; Neomycin; Nicotinic Acids; Norepinephrine; omega-Conotoxin GVIA; Oxadiazoles; Phorbol Esters; Quinoxalines; Rabbits | 1988 |
Greater vasodepressor sensitivity to nicardipine in spontaneously hypertensive rats (SHR) compared to normotensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Decerebrate State; Hemodynamics; Male; Nicardipine; Pentolinium Tartrate; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY | 1988 |
Alpha 1- and alpha 2-adrenoceptor stimulation: changes in venous capacitance in intact dogs.
Topics: Animals; Arteries; Blood Volume; Brimonidine Tartrate; Dogs; Ganglia; Hemodynamics; Methoxamine; Nerve Block; Quinoxalines; Receptors, Adrenergic; Regional Blood Flow; Stimulation, Chemical; Vascular Resistance; Veins | 1986 |
UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pulmonary Artery; Quinoxalines; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1981 |
Functional and biochemical evidence for the lack of cardiac presynaptic alpha-2 adrenoceptor stimulant properties of cirazoline (LD 3098), a potent alpha-1 adrenoceptor agonist in dogs and rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Blood Vessels; Brimonidine Tartrate; Clonidine; Dogs; Female; Heart; Heart Rate; Imidazoles; Male; Norepinephrine; Oxymetazoline; Pentobarbital; Quinoxalines; Rats; Spinal Cord; Synapses; Tachycardia; Vagotomy | 1982 |
Blockade and postjunctional vascular alpha 1- and alpha 2-adrenoceptors in pithed rat by the enantiomers of WB-4101.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Brimonidine Tartrate; Dioxanes; Dioxins; Dose-Response Relationship, Drug; Imidazoles; Isomerism; Male; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Regression Analysis; Spinal Cord | 1983 |
Sleeping times evoked by alpha adrenoceptor agonists in two-day-old chicks: an experimental model to evaluate full and partial agonists at central alpha-2 adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Chickens; Clonidine; Guanabenz; Guanfacine; Guanidines; Imidazoles; Phenylacetates; Quinoxalines; Receptors, Adrenergic, alpha; Sleep; Thiophenes; Time Factors; Xylazine | 1983 |
Effect of 781094, a new selective alpha-adrenoceptor antagonist, on the aggregatory responses of human blood platelets and on binding of [3H]-dihydroergocryptine to these cells.
Topics: Adrenergic alpha-Antagonists; Blood Platelets; Brimonidine Tartrate; Clonidine; Dihydroergotoxine; Dioxins; Epinephrine; Humans; Idazoxan; Methoxamine; Platelet Aggregation; Quinoxalines; Serotonin; Tritium | 1983 |
Neuronal responses to noradrenaline in the cerebral cortex: evidence against the involvement of alpha 2-adrenoceptors.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Idazoxan; Male; Neurons; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1984 |
Binding of the imidazoline UK-14, 304, a putative full alpha 2-adrenoceptor agonist, to rat cerebral cortex membranes.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Kinetics; Male; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha | 1984 |
Alpha 2-adrenoceptor agonists potentiate responses mediated by alpha 1-adrenoceptors in the cat nictitating membrane.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cats; Clonidine; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nictitating Membrane; Norepinephrine; Phenylephrine; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha | 1984 |
Pharmacological characterization of alpha adrenoceptors in the rat gastric fundus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Electric Stimulation; Female; Gastric Fundus; In Vitro Techniques; Methacholine Compounds; Muscle Contraction; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Receptors, Adrenergic, alpha | 1984 |
The contractions induced in rat and guinea-pig aortic strips by the alpha 2-adrenoceptor selective agonists B-HT 920 and UK 14,304 are mediated by alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Azepines; Brimonidine Tartrate; Dose-Response Relationship, Drug; Gallopamil; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Species Specificity; Yohimbine | 1984 |
alpha-adrenoreceptor-mediated phasic and tonic activity in rat portal vein in vitro.
Topics: Animals; Brimonidine Tartrate; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Portal Vein; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha | 1983 |
Postsynaptic alpha adrenoceptors and attenuation of vascular sympathetic responses in SHRs by captopril and enalapril.
Topics: Animals; Blood Pressure; Brimonidine Tartrate; Captopril; Dipeptides; Enalapril; Heart Rate; Imidazoles; Male; Pressoreceptors; Proline; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vascular Resistance; Vasoconstriction | 1983 |
Noradrenergic regulation of growth hormone secretion in the baboon.
Topics: Albuterol; Animals; Brimonidine Tartrate; Dose-Response Relationship, Drug; Female; Growth Hormone; Male; Papio; Practolol; Prazosin; Propanolamines; Propranolol; Quinoxalines; Receptors, Adrenergic | 1983 |
Alpha 2-adrenoceptors and the regulation of glucose, insulin and amylin levels in diabetic rats.
Topics: Amyloid; Animals; Blood Glucose; Brimonidine Tartrate; Diabetes Mellitus, Experimental; Female; Insulin; Islet Amyloid Polypeptide; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Streptozocin | 1995 |
Subclassification of presynaptic alpha 2-adrenoceptors: alpha 2D-autoreceptors in mouse brain.
Topics: Adrenergic alpha-Agonists; Animals; Autoreceptors; Binding, Competitive; Brain; Brimonidine Tartrate; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Presynaptic Terminals; Quinoxalines; Receptors, Adrenergic, alpha-2; Tetrodotoxin; Yohimbine | 1995 |
Subclassification of presynaptic alpha 2-adrenoceptors: alpha 2D-autoreceptors in guinea-pig atria and brain.
Topics: Adrenergic alpha-Agonists; Animals; Autoreceptors; Brimonidine Tartrate; Cerebral Cortex; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Male; Phentolamine; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
Subclassification of presynaptic alpha 2-adrenoceptors: alpha 2D-autoreceptors and alpha 2D-adrenoceptors modulating release of acetylcholine in guinea-pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Autoreceptors; Brimonidine Tartrate; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; Male; Phentolamine; Quinoxalines; Receptors, Adrenergic, alpha-2; Time Factors | 1995 |
Peripheral nociceptive effects of alpha 2-adrenergic receptor agonists in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Calcimycin; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Indoles; Isoindoles; Male; Norepinephrine; Pain Measurement; Peripheral Nervous System; Quinoxalines; Rats; Rats, Sprague-Dawley; Yohimbine | 1995 |
Protective effects of an indenoindole antioxidant on coronary endothelial function after long-term storage.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Antioxidants; Bradykinin; Brimonidine Tartrate; Calcimycin; Cardioplegic Solutions; Coronary Vessels; Dogs; Endothelium, Vascular; Heart Transplantation; Indoles; Isoproterenol; Male; Muscle, Smooth, Vascular; Nitric Oxide; Quinoxalines; Tissue Preservation | 1995 |
Involvement of alpha 2-adrenoceptors in the cardiovascular effects of moxonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Cisterna Magna; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Norepinephrine; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 1995 |
Involvement of peripheral presynaptic inhibition in the reduction of sympathetic tone by moxonidine, rilmenidine and UK 14304.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Imidazoles; Male; Neural Inhibition; Oxazoles; Peripheral Nervous System; Presynaptic Terminals; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Vasoconstrictor Agents | 1995 |
Identification of alpha 2-adrenoceptors in rat lymph nodes and spleen: an autoradiographic study.
Topics: Animals; Autoradiography; Binding Sites; Brimonidine Tartrate; Frozen Sections; Lymph Nodes; Male; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Spleen; Staining and Labeling; Tissue Preservation | 1994 |
Regulation of p42 and p44 MAP kinase isoforms in Rat-1 fibroblasts stably transfected with alpha 2C10 adrenoreceptors.
Topics: Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Activation; Epidermal Growth Factor; Glycogen Synthase Kinase 3; In Vitro Techniques; Isoenzymes; Mitogen-Activated Protein Kinase 1; Phosphotyrosine; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tyrosine | 1994 |
Alpha 2-adrenoceptor-mediated inhibition of electrically evoked [3H]noradrenaline release from chick sympathetic neurons: role of cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Adrenergic Fibers; Animals; Brimonidine Tartrate; Calcium Channels; Cells, Cultured; Chick Embryo; Cholera Toxin; Colforsin; Cyclic AMP; Electric Stimulation; Neurons; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2; Tritium | 1994 |
Antinociception following implantation of mouse B16 melanoma cells in mouse and rat spinal cord.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Catecholamines; Cell Transplantation; Desipramine; Dioxanes; Idazoxan; Injections, Spinal; Male; Melanoma, Experimental; Mice; Mice, Inbred ICR; Morphine; Naloxone; Neoplasm Transplantation; Nociceptors; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Substance P; Transplantation, Heterotopic | 1994 |
Effect of potassium channel blockade and alpha 2-adrenoceptor activation on the release of nitric oxide from non-adrenergic non-cholinergic nerves.
Topics: 4-Aminopyridine; Adrenergic alpha-Agonists; Animals; Arginine; Autonomic Nervous System; Brimonidine Tartrate; Charybdotoxin; Dogs; Electric Stimulation; Female; Male; Nitric Oxide; Nitroarginine; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha-2; Scorpion Venoms; Tetraethylammonium Compounds; Tetrodotoxin; Yohimbine | 1994 |
Chronic changes in blood flow alter endothelium-dependent responses in autogenous vein grafts in dogs.
Topics: Acetylcholine; Adenosine Diphosphate; Adrenergic alpha-Agonists; Animals; Arginine; Arteriovenous Shunt, Surgical; Blood Flow Velocity; Brimonidine Tartrate; Calcimycin; Constriction; Dinoprost; Dogs; Endothelins; Endothelium, Vascular; Femoral Artery; Femoral Vein; Hyperplasia; Male; Models, Biological; Neovascularization, Pathologic; Nitric Oxide; omega-N-Methylarginine; Quinoxalines; Thrombin; Tunica Intima; Vascular Patency | 1994 |
Interactions between inhibitory and excitatory modulatory signals in single submucosal neurons.
Topics: 2-Chloroadenosine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Electrophysiology; Female; Guinea Pigs; Male; Neurons; Norepinephrine; Phorbol 12,13-Dibutyrate; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction; Somatostatin; Submucous Plexus; Substance P | 1994 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Pharmacological characterization of alpha 2-adrenoceptor regulated serotonin release in the rat hippocampus.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Dioxanes; GTP-Binding Proteins; Hippocampus; Idazoxan; Imidazoles; Male; Oxidopamine; Pertussis Toxin; Potassium; Quinoxalines; Rats; Rats, Wistar; Second Messenger Systems; Serotonin; Tetrodotoxin; Virulence Factors, Bordetella | 1995 |
Permissive role of NO in alpha 2-adrenoceptor-mediated dilations in rat cerebral arteries.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cerebral Arteries; In Vitro Techniques; Male; Nitric Oxide; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasodilation | 1995 |
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
Comparative ocular pharmacokinetics of brimonidine after a single dose application to the eyes of albino and pigmented rabbits.
Topics: Adrenergic alpha-Agonists; Albinism, Oculocutaneous; Animals; Brimonidine Tartrate; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Eye; Female; Ophthalmic Solutions; Pigment Epithelium of Eye; Quinoxalines; Rabbits | 1995 |
Contrasting effects of the imidazol(in)e alpha 2-adrenoceptor agonists, medetomidine, clonidine and UK 14,304 on extraneuronal levels of noradrenaline in the rat frontal cortex: evaluation using in vivo microdialysis and synaptosomal uptake studies.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Frontal Lobe; Imidazoles; Male; Medetomidine; Microdialysis; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors | 1995 |
Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Base Sequence; Brimonidine Tartrate; Bucladesine; Catecholamines; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dioxanes; DNA Primers; Epididymis; Gene Expression; Idazoxan; Isoproterenol; Lipase; Lipolysis; Male; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Propanolamines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA, Messenger; Skin | 1995 |
Rapid, agonist-induced desensitization of alpha 2-autoreceptors modulating transmitter release.
Topics: Adrenergic alpha-Agonists; Animals; Autoreceptors; Brimonidine Tartrate; Cells, Cultured; Chick Embryo; Electric Stimulation; In Vitro Techniques; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Time Factors | 1995 |
Adrenoceptor-stimulated endothelium-dependent relaxation in porcine intrapulmonary arteries.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Dose-Response Relationship, Drug; Endothelium, Vascular; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prazosin; Pulmonary Artery; Quinoxalines; Swine; Yohimbine | 1994 |
Alpha 2-adrenoceptor-mediated vasoconstriction requires a tyrosine kinase.
Topics: Animals; Aorta; Brimonidine Tartrate; Cinnamates; Dose-Response Relationship, Drug; Genistein; Hydroquinones; Isoflavones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Protein-Tyrosine Kinases; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Saphenous Vein; Vasoconstriction | 1995 |
Involvement of protein kinase C activation in alpha 2-adrenoceptor-mediated contractions of rabbit saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkaloids; Animals; Brimonidine Tartrate; Calcium; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Inositol Phosphates; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Phosphatidic Acids; Phospholipase D; Protein Kinase C; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Saphenous Vein; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
Adrenergic receptor-mediated Cl- transport in rabbit corneal endothelial cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acetates; Acetazolamide; Adrenergic Agonists; Adrenergic Antagonists; Affinity Labels; Animals; Brimonidine Tartrate; Cells, Cultured; Chlorides; Colforsin; Dose-Response Relationship, Drug; Endothelium, Corneal; Fluorescent Dyes; Ion Transport; Isoproterenol; Microscopy, Fluorescence; Norepinephrine; Phentolamine; Phenylephrine; Photometry; Quinolines; Quinoxalines; Rabbits; Receptors, Adrenergic; Yohimbine | 1995 |
Alpha 2-adrenoceptor mediated inhibition of [3H]dopamine release from nucleus accumbens slices and monoamine levels in a rat model for attention-deficit hyperactivity disorder.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Attention Deficit Disorder with Hyperactivity; Biogenic Monoamines; Brimonidine Tartrate; Disease Models, Animal; Dopamine; Hypertension; In Vitro Techniques; Male; Neurons; Norepinephrine; Nucleus Accumbens; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Tritium | 1995 |
Regional differences in adipose tissue lipolysis from lean and obese women: existence of postreceptor alterations.
Topics: Abdomen; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adult; Brimonidine Tartrate; Epinephrine; Female; Humans; Lipolysis; Obesity; Quinoxalines; Receptors, Adrenergic; Reference Values; Thigh; Tissue Distribution | 1995 |
Inhibition by 5-hydroxytryptamine and noradrenaline in substantia gelatinosa of guinea-pig spinal trigeminal nucleus.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Guinea Pigs; In Vitro Techniques; Male; Membrane Potentials; Neurons; Nociceptors; Norepinephrine; Potassium Channels; Quinoxalines; Receptors, GABA-A; Serotonin; Serotonin Receptor Agonists; Substantia Gelatinosa; Synapses; Trigeminal Nucleus, Spinal | 1995 |
Mechanism of sympathoinhibition by imidazolines.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1995 |
Adrenergic and imidazoline receptor-mediated responses to UK-14,304-18 (brimonidine) in rabbits and monkeys. A species difference.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Ciliary Body; Female; Imidazoles; Imidazoline Receptors; Macaca fascicularis; Male; Quinoxalines; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug; Species Specificity | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
Lack of effect of sumatriptan and UK-14,304 on capsaicin-induced relaxation of guinea-pig isolated basilar artery.
Topics: Animals; Basilar Artery; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Male; Quinoxalines; Ruthenium Red; Substance P; Sulfonamides; Sumatriptan; Vasoconstrictor Agents; Vasodilation | 1993 |
Inhibition of insulin release induced by galanin in the dog is not exclusively mediated by activation of ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Diazoxide; Dioxanes; Dogs; Female; Galanin; Ganglia, Sympathetic; Glyburide; Idazoxan; Insulin; Insulin Secretion; Male; Norepinephrine; Pancreas; Peptides; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha; Sensitivity and Specificity | 1993 |
Sensory nerve-mediated relaxation of guinea-pig isolated pulmonary artery: prejunctional modulation by alpha 2-adrenoceptor agonists but not sumatriptan.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Electric Stimulation; Guinea Pigs; Histamine; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Junction; Neurons, Afferent; Piperazines; Pulmonary Artery; Pyrrolidines; Quinoxalines; Substance P; Sulfonamides; Sumatriptan; Vasoconstrictor Agents; Yohimbine | 1993 |
Interaction between nicotinic cholinergic receptors and alpha-2 adrenergic systems in regulating growth hormone secretion in conscious rats.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Consciousness; Galanin; Growth Hormone; Male; Mollusk Venoms; Peptides; Pituitary Gland; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Nicotinic | 1993 |
Apraclonidine and brimonidine effects on anterior ocular and cardiovascular physiology in normal and sympathectomized monkeys.
Topics: Adrenergic alpha-Agonists; Animals; Aqueous Humor; Blood Pressure; Body Weight; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Intraocular Pressure; Macaca fascicularis; Macaca mulatta; Male; Pupil; Quinoxalines; Refraction, Ocular; Sympathectomy | 1994 |
Gi down-regulation and heterologous desensitization in adipocytes after treatment with the alpha 2-agonist UK 14304.
Topics: Adipocytes; Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Down-Regulation; GTP-Binding Proteins; Lipolysis; Male; Quinoxalines; Rats; Rats, Sprague-Dawley | 1995 |
Alpha 2D-adrenoceptors modulate renal noradrenaline release in normotensive and spontaneously hypertensive rats.
Topics: Animals; Binding Sites; Blood Pressure; Brimonidine Tartrate; Electric Stimulation; Hypertension; Kidney; Norepinephrine; Perfusion; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2 | 1994 |
Evidence for G beta gamma-mediated cross-talk in primary cultures of lung alveolar cells. Pertussis toxin-sensitive production of cAMP.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Membrane; Cells, Cultured; Cyclic AMP; DNA Probes; Gene Expression; GTP-Binding Proteins; Kinetics; Macromolecular Substances; Male; Pertussis Toxin; Pulmonary Alveoli; Quinoxalines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Terbutaline; Virulence Factors, Bordetella | 1995 |
Functional expression of adrenergic and opioid receptors in Xenopus oocytes: interaction between alpha 2- and beta 2-adrenergic receptors.
Topics: Adenylyl Cyclases; Animals; Brimonidine Tartrate; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis; Dose-Response Relationship, Drug; Isoproterenol; Models, Biological; Naloxone; Oocytes; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Receptors, Opioid; RNA, Messenger; Xenopus laevis | 1995 |
Long-term administration of 1,3-dipropyl-8-sulphophenylxanthine (DPSPX) alters alpha 2-adrenoceptor-mediated effects at the pre- but not at the postjunctional level.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Arteries; Brimonidine Tartrate; Hypertension; Male; Neuroeffector Junction; NG-Nitroarginine Methyl Ester; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P1; Tail; Xanthines | 1994 |
Adrenergic modulation of a spinal sympathetic reflex in the rat.
Topics: Animals; Brimonidine Tartrate; Clonidine; Male; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Spinal Cord; Sympathetic Nervous System | 1995 |
Agmatine recognizes alpha 2-adrenoceptor binding sites but neither activates nor inhibits alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Agmatine; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Clonidine; Cyclic AMP; In Vitro Techniques; Male; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 1995 |
Differential actions of lamprey peptide methionine-tyrosine at Y1 and Y2 neuropeptide Y receptors.
Topics: Amino Acid Sequence; Animals; Brimonidine Tartrate; Guinea Pigs; In Vitro Techniques; Male; Mesenteric Arteries; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Peptides; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Vas Deferens | 1994 |
Activation of alpha-2-adrenoceptors results in an increase in F-actin formation in HIT-T15 pancreatic B-cells.
Topics: Actins; Adenoma, Islet Cell; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Biopolymers; Brimonidine Tartrate; Cytochalasins; Dioxanes; Drug Interactions; Exocytosis; Fluorescent Dyes; Gene Expression Regulation; Idazoxan; Insulin; Insulin Secretion; Islets of Langerhans; Neoplasm Proteins; Norepinephrine; Pertussis Toxin; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
Effects of alpha-adrenoceptor agonists and antagonists on metabolic rate in cattle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basal Metabolism; Body Temperature; Brimonidine Tartrate; Cattle; Clonidine; Dioxanes; Female; Guanfacine; Heart Rate; Idazoxan; Male; Prazosin; Quinoxalines | 1995 |
Prejunctional interaction of alpha 2-adrenoceptors and D2 dopamine receptors on perivascular sympathetic nerves.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cocaine; Electric Stimulation; In Vitro Techniques; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Sympathetic Nervous System; Tail; Tetrahydronaphthalenes; Thiophenes; Yohimbine | 1995 |
Electrophysiological effects of alpha 2-adrenergic stimulation in canine cardiac Purkinje fibers.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Electrophysiology; Female; Male; Pertussis Toxin; Purkinje Fibers; Quinoxalines; Receptors, Adrenergic, beta; Ventricular Function; Virulence Factors, Bordetella | 1995 |
Control of lipolysis in intra-abdominal fat cells of nonhuman primates: comparison with humans.
Topics: Abdomen; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenocorticotropic Hormone; Aged; Animals; Brimonidine Tartrate; Bucladesine; Callithrix; Colforsin; Female; Humans; In Vitro Techniques; Lipolysis; Macaca fascicularis; Male; Middle Aged; Papio; Peptide YY; Peptides; Primates; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Species Specificity | 1995 |
Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein.
Topics: 3T3 Cells; Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Cattle; Cell Line; Cell Membrane; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Kinetics; Mice; PC12 Cells; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Signal Transduction; Transfection; Virulence Factors, Bordetella | 1995 |
Modulation of electrically evoked [3H]-noradrenaline release from cultured chick sympathetic neurons.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channels; Cells, Cultured; Chick Embryo; Clonidine; Electric Stimulation; Isoproterenol; Neurons; Norepinephrine; Quinoxalines; Receptors, Adrenergic; Receptors, Glutamate; Sensitivity and Specificity; Sympathetic Nervous System; Temperature; Tetrodotoxin; Tritium | 1994 |
Neuronal excitation by angiotensin II in the rostral ventrolateral medulla of the rat in vitro.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Biphenyl Compounds; Brimonidine Tartrate; Evoked Potentials; Imidazoles; In Vitro Techniques; Kynurenic Acid; Losartan; Medulla Oblongata; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetrazoles; Time Factors | 1995 |
Effects of moxonidine, an imidazoline antihypertensive agent, on second messenger systems in rat brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Brain Chemistry; Brain Stem; Brimonidine Tartrate; Cerebral Cortex; Colforsin; Cyclic AMP; Cyclic GMP; Imidazoles; In Vitro Techniques; Norepinephrine; Phosphatidylinositols; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Second Messenger Systems; Yohimbine | 1994 |
Pertussis toxin attenuates presynaptic inhibition of cholinergic but not nonadrenergic noncholinergic contraction in guinea pig airways.
Topics: Animals; Brimonidine Tartrate; Bronchi; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guinea Pigs; Male; Muscle Contraction; Parasympathetic Nervous System; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Trachea; Virulence Factors, Bordetella | 1995 |
Adrenergic receptors in the cerebellum of olivopontocerebellar atrophy.
Topics: Aged; Brimonidine Tartrate; Cerebellar Cortex; Cerebellum; Humans; Nerve Tissue Proteins; Norepinephrine; Olivopontocerebellar Atrophies; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta | 1994 |
Noradrenaline release from rat sympathetic neurons evoked by P2-purinoceptor activation.
Topics: Adenosine Triphosphate; Animals; Brimonidine Tartrate; Calcium; Cells, Cultured; Electric Stimulation; In Vitro Techniques; Norepinephrine; Purinergic P2 Receptor Agonists; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Superior Cervical Ganglion; Suramin; Tetrodotoxin; Triazines; Xanthines | 1994 |
Presynaptic alpha 2A-adrenoceptors inhibit the release of endogenous dopamine in rabbit caudate nucleus slices.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Caudate Nucleus; Cell Line; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Quinoxalines; Rabbits; Receptors, Presynaptic | 1994 |
Presynaptic alpha 2-adrenoceptors inhibit calcium influx in terminals of chicken sympathetic neurons and noradrenaline release evoked by nicotinic stimulation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Calcium; Cells, Cultured; Chick Embryo; Dimethylphenylpiperazinium Iodide; Fluorometry; Fura-2; Nerve Endings; Neurons; Nicotinic Agonists; Norepinephrine; Quinoxalines; Stimulation, Chemical; Sympathetic Nervous System | 1994 |
A pathogenic role of visceral fat beta 3-adrenoceptors in obesity.
Topics: Adipose Tissue; Adrenergic Agonists; Adult; Brimonidine Tartrate; Dobutamine; Dose-Response Relationship, Drug; Female; Humans; Lipolysis; Male; Norepinephrine; Obesity; Omentum; Propanolamines; Quinoxalines; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-2; Receptors, Adrenergic, beta-3; Terbutaline | 1995 |
Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.
Topics: Adenosine Diphosphate Ribose; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cholera Toxin; Fibroblasts; Gene Expression; GTP-Binding Proteins; Guanosine Diphosphate; Humans; Immunosorbent Techniques; NAD; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Transfection; Virulence Factors, Bordetella; Yohimbine | 1995 |
The combined 5-HT2 receptor and calcium channel inhibitor LU49938 restores endothelium dependent responses in the regenerated endothelium of the porcine coronary artery.
Topics: Adrenergic alpha-Antagonists; Angioplasty, Balloon; Animals; Blood Platelets; Brimonidine Tartrate; Calcium Channel Blockers; Coronary Angiography; Coronary Vessels; Endothelins; Endothelium, Vascular; In Vitro Techniques; Male; Norepinephrine; Quinoxalines; Random Allocation; Regeneration; Serotonin; Serotonin Antagonists; Swine; Tunica Intima; Vasoconstriction; Verapamil | 1995 |
Anisodamine at higher concentrations in inhibiting alpha-adrenergic responses in isolated canine blood vessels.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Femoral Artery; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Saphenous Vein; Solanaceous Alkaloids | 1993 |
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Clonidine; Dihydroxyphenylalanine; Dioxanes; Idazoxan; Injections, Subcutaneous; Male; Mydriasis; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reserpine; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Regional distribution and heterogeneity of alpha-adrenoceptors in the rat and human central nervous system.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Brain; Brain Chemistry; Brimonidine Tartrate; Humans; Organ Specificity; Prazosin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Species Specificity; Tritium; Yohimbine | 1993 |
Chloroethylclonidine irreversibly activates postjunctional alpha 2-adrenoceptors in the dog saphenous vein.
Topics: Adrenergic alpha-Agonists; Alkylating Agents; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Dogs; Female; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Saphenous Vein | 1993 |
Pharyngeal, esophageal, and proximal gastric responses associated with vomiting.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Brimonidine Tartrate; Dogs; Electromyography; Esophagus; Female; Intestine, Small; Male; Models, Biological; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Nerve Block; Pharynx; Quinoxalines; Stomach; Vagus Nerve; Vomiting | 1993 |
Nitric oxide modulates sympathetic vasoconstriction and basal blood flow in normal and acutely inflamed rabbit knee joints.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Arthritis; Blood Pressure; Brimonidine Tartrate; Clonidine; Electric Stimulation; Infusions, Intra-Arterial; Knee Joint; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Quinoxalines; Rabbits; Regional Blood Flow; Sympathetic Nervous System; Vascular Resistance; Vasoconstriction | 1993 |
Neural ATP release and its alpha 2-adrenoceptor-mediated modulation in guinea-pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neurons; Norepinephrine; Prazosin; Purinergic P2 Receptor Antagonists; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2; Suramin; Vas Deferens; Yohimbine | 1993 |
Prejunctional alpha 2-adrenoceptors inhibit acetylcholine release from cholinergic nerves in equine airways.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Trachea; Yohimbine | 1993 |
ANG II reverses selective inhibition of alpha 2-adrenoceptor sensitivity after in vitro isolation of arterioles.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Arterioles; Brimonidine Tartrate; Histological Techniques; In Vitro Techniques; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Yohimbine | 1993 |
Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Azepines; Brimonidine Tartrate; Dioxanes; GTP Phosphohydrolases; Humans; Idazoxan; Isoproterenol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinoxalines; Receptors, Adrenergic, alpha; Superoxides; Tritium; Tumor Cells, Cultured | 1994 |
Effects of alpha-2-adrenergic drugs in the medial preoptic area and medial basal hypothalamus on lordosis in the guinea pig.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Estradiol; Female; Guinea Pigs; Hypothalamus, Middle; Posture; Preoptic Area; Progesterone; Quinoxalines; Receptors, Adrenergic, alpha-2; Sexual Behavior, Animal; Synaptic Transmission; Yohimbine | 1993 |
Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Enzyme Activation; GTP-Binding Proteins; Mice; Quinoxalines; Receptors, Adrenergic, alpha-2; Signal Transduction; Swine; Type C Phospholipases | 1994 |
Release-inhibiting alpha 2-adrenoceptors at serotonergic axons in rat and rabbit brain cortex: evidence for pharmacological identity with alpha 2-autoreceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Axons; Brimonidine Tartrate; Cerebral Cortex; Female; Kinetics; Male; Mianserin; Norepinephrine; Pyridines; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin; Thiazoles; Tritium | 1994 |
Differential desensitization and phosphorylation of three cloned and transfected alpha 2-adrenergic receptor subtypes.
Topics: Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Brimonidine Tartrate; Cell Line; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Kinetics; Molecular Sequence Data; Molecular Weight; Norepinephrine; Phosphates; Phosphorylation; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection | 1994 |
Estradiol reduction of the agonist high affinity form of the alpha 2-adrenoceptor in the hypothalamus of female rats: identification as the alpha 2D subtype.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Dioxanes; Estradiol; Female; Hypothalamus; Idazoxan; Kinetics; Preoptic Area; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Autoradiographic demonstration of increased alpha 2-adrenoceptor agonist binding sites in the hippocampus and frontal cortex of depressed suicide victims.
Topics: Adrenergic alpha-Agonists; Adult; Autoradiography; Binding Sites; Brain Chemistry; Brimonidine Tartrate; Cerebral Cortex; Depression; Female; Hippocampus; Humans; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Suicide | 1994 |
Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Brain Chemistry; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Dioxanes; Female; GTP-Binding Proteins; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1994 |
Alpha 2-adrenergic receptors of the alpha 2c subtype mediate inhibition of norepinephrine release in human kidney cortex.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Interactions; Humans; In Vitro Techniques; Indomethacin; Kidney Cortex; Norepinephrine; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha-2; Theophylline | 1994 |
Effect of morphine and abstinence syndrome on [3H]bromoxidine binding to alpha 2-adrenoceptors in rat brain.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Brain; Brimonidine Tartrate; Drug Implants; Hippocampus; Male; Mesencephalon; Morphine; Morphine Dependence; Naloxone; Occipital Lobe; Organ Specificity; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reference Values; Substance Withdrawal Syndrome; Superior Colliculi; Tritium | 1994 |
Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors?
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Brimonidine Tartrate; Dose-Response Relationship, Drug; Heart Rate; Imidazoline Receptors; Kidney; Oxazoles; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System | 1994 |
VIP inhibits N-type Ca2+ channels of sympathetic neurons via a pertussis toxin-insensitive but cholera toxin-sensitive pathway.
Topics: Animals; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Channels; Cholera Toxin; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Ganglia, Sympathetic; GTP-Binding Proteins; Neurons; Pertussis Toxin; Quinoxalines; Rats; Rats, Wistar; Second Messenger Systems; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1994 |
Alpha-2 adrenoceptor mediated changes in aqueous dynamics: effect of pertussis toxin.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Cyclic AMP; Intraocular Pressure; Kinetics; Norepinephrine; Pertussis Toxin; Quinoxalines; Rabbits; Uvea; Virulence Factors, Bordetella | 1994 |
Multiple alpha-2 adrenergic receptor subtypes. II. Evidence for a role of rat R alpha-2A adrenergic receptors in the control of nociception, motor behavior and hippocampal synthesis of noradrenaline.
Topics: Animals; Brimonidine Tartrate; Hippocampus; Male; Motor Activity; Norepinephrine; Pain; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 1994 |
Specificity and functional applications of antipeptide antisera which identify G-protein alpha subunits.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Antibody Specificity; Blotting, Western; Brimonidine Tartrate; Cell Line; Cell Membrane; Colforsin; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Erythrocyte Membrane; GTP Phosphohydrolases; GTP-Binding Proteins; Immune Sera; Immunoassay; Indicators and Reagents; Kinetics; Macromolecular Substances; Molecular Sequence Data; Peptides; Quinoxalines; Recombinant Proteins; Turkeys | 1994 |
Activation of sensory nerves in guinea-pig isolated basilar artery by nicotine: evidence for inhibition of trigeminal sensory neurotransmission by sumatriptan.
Topics: Animals; Basilar Artery; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Nicotine; Peptide Fragments; Potassium Chloride; Quinoxalines; Sumatriptan; Synaptic Transmission; Trigeminal Nerve | 1994 |
[Pharmacological characterization of alpha 2-adrenoceptor regulated 5-HT release in the rat hippocampus].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dioxanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hippocampus; Idazoxan; Microdialysis; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin | 1994 |
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
Topics: 3T3 Cells; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Clone Cells; Clonidine; Cyclic AMP; Dioxanes; Humans; Idazoxan; Kinetics; Male; Mice; Pertussis Toxin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1994 |
Palmitoylation of the alpha 2A-adrenergic receptor. Analysis of the sequence requirements for and the dynamic properties of alpha 2A-adrenergic receptor palmitoylation.
Topics: Acylation; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Base Sequence; Brimonidine Tartrate; DNA Primers; In Vitro Techniques; Molecular Sequence Data; Mutagenesis, Site-Directed; Palmitates; Protein Processing, Post-Translational; Quinoxalines; Receptors, Adrenergic, alpha; Recombinant Proteins; Structure-Activity Relationship; Swine; Yohimbine | 1994 |
ATP-sensitive K+ channels mediate alpha 2D-adrenergic receptor contraction of arteriolar smooth muscle and reversal of contraction by hypoxia.
Topics: Adenosine Triphosphate; Animals; Brimonidine Tartrate; Cell Hypoxia; Clonidine; Glyburide; In Vitro Techniques; Muscle, Smooth, Vascular; Nitroprusside; Phenylephrine; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction | 1995 |
Effects of wortmannin on alpha-1/alpha-2 adrenergic receptor-mediated contractile responses in rabbit vascular tissues.
Topics: Androstadienes; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium; Dose-Response Relationship, Drug; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Saphenous Vein; Wortmannin | 1994 |
Effect of an intracellular calcium chelator on the regulation of electrically evoked [3H]-noradrenaline release from rat hippocampal slices.
Topics: Adenosine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Chelating Agents; Dioxanes; Egtazic Acid; Electric Stimulation; Hippocampus; Idazoxan; In Vitro Techniques; Male; Norepinephrine; omega-Conotoxins; Peptides, Cyclic; Quinoxalines; Rats; Rats, Sprague-Dawley | 1993 |
Influences of the endothelium and hypoxia on alpha 1- and alpha 2-adrenoceptor-mediated responses in the rabbit isolated pulmonary artery.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Oxygen; Phenylephrine; Pulmonary Artery; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Vasoconstriction | 1993 |
Dopamine DA2-receptor activation inhibits noradrenaline release in human kidney slices.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Brimonidine Tartrate; Calcium; Dopamine Agents; Ergolines; Fenoldopam; Humans; In Vitro Techniques; Indoles; Kidney Cortex; Middle Aged; Norepinephrine; Oxidopamine; Pyridines; Quinoxalines; Quinpirole; Receptors, Dopamine D2; Sulpiride; Tetrodotoxin | 1993 |
Cyclic AMP modulates but does not mediate the inhibition of [3H]norepinephrine release by activation of alpha-2 adrenergic receptors in cultured rat ganglion cells.
Topics: Adrenergic alpha-Agonists; Animals; Animals, Newborn; Brimonidine Tartrate; Cells, Cultured; Chromatography, Paper; Colforsin; Cyclic AMP; Electric Stimulation; Ganglia, Sympathetic; In Vitro Techniques; Norepinephrine; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Thionucleotides | 1993 |
Mechanisms of signal transduction during alpha 2-adrenergic receptor-mediated contraction of vascular smooth muscle.
Topics: Actin Cytoskeleton; Adrenergic alpha-Agonists; Aequorin; Animals; Brimonidine Tartrate; Calcium; Female; Homeostasis; Male; Muscle, Smooth, Vascular; Myosins; Phosphorylation; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Saphenous Vein; Signal Transduction; Vasoconstriction | 1993 |
Autoradiographic demonstration of loss of alpha 2-adrenoceptors in progressive supranuclear palsy: preliminary report.
Topics: Adrenergic alpha-Agonists; Aged; Autoradiography; Brain; Brimonidine Tartrate; Humans; Male; Organ Specificity; Quinoxalines; Receptors, Adrenergic, alpha; Supranuclear Palsy, Progressive; Tritium | 1993 |
Alpha-adrenergic receptor responsiveness in vascular smooth muscle of canine bone.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Regional Blood Flow; Tibia; Yohimbine | 1993 |
Methoxamine inhibits noradrenaline release through activation of alpha 1- and alpha 2-adrenoceptors in rat isolated kidney: involvement of purines and prostaglandins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Drug Interactions; In Vitro Techniques; Kidney; Male; Methoxamine; Norepinephrine; Perfusion; Prostaglandins; Purines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha | 1993 |
Lack of interaction between alpha 2-adrenoceptors and dopamine D2-receptors in mediating their inhibitory effects on [3H]dopamine release from rat nucleus accumbens slices.
Topics: Adrenergic alpha-Agonists; Animals; Apomorphine; Binding, Competitive; Brimonidine Tartrate; Dopamine; Electric Stimulation; Ergolines; GTP-Binding Proteins; Haloperidol; In Vitro Techniques; Male; Nucleus Accumbens; Pergolide; Quinoxalines; Quinpirole; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Dopamine D2; Signal Transduction; Sulpiride | 1993 |
In vivo pharmacological profile of SL 84.0418, a new selective, peripherally active alpha 2-adrenoceptor antagonist.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Epinephrine; Heart Rate; Hyperglycemia; Idazoxan; Indoles; Male; Mice; Motor Activity; Norepinephrine; Peripheral Nerves; Prazosin; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasoconstriction | 1993 |
Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Platelets; Blood Proteins; Brimonidine Tartrate; Cell Membrane; Dioxanes; Epinephrine; Humans; Hydroxylation; Idazoxan; In Vitro Techniques; Lipolysis; Male; Platelet Aggregation; Protein Binding; Quinoxalines; Yohimbine | 1993 |
Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cell Membrane; Colon; Dioxanes; Duodenum; Epinephrine; Epithelium; Humans; Idazoxan; Intestinal Mucosa; Kinetics; Microvilli; NAD; Organ Specificity; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Virulence Factors, Bordetella | 1993 |
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dioxanes; GTP-Binding Proteins; Humans; Idazoxan; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Naloxone-induced potentiation of cardiac alpha-2 adrenoceptor-mediated depression of neurogenic tachycardia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Depression, Chemical; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Heart; Male; Myocardium; Naloxone; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Sympathetic Nervous System; Tachycardia | 1993 |
L-dopa potentiates presynaptic inhibitory alpha 2-adrenoceptor- but not facilitatory angiotensin II receptor-mediated modulation of noradrenaline release from rat hypothalamic slices.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Brimonidine Tartrate; Hypothalamus; In Vitro Techniques; Levodopa; Male; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Angiotensin; Synapses; Yohimbine | 1993 |
Acute and chronic effects of cholinesterase inhibitors and pilocarpine on the density and sensitivity of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Cholinesterase Inhibitors; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Isoflurophate; Male; Neostigmine; Physostigmine; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Postjunctional alpha 2-adrenoceptors in blood vessels: effect of age.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Idazoxan; Male; Methoxamine; Norepinephrine; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha; Tail; Vasoconstriction; Yohimbine | 1993 |
The release of endothelium-derived relaxing factor via alpha 2-adrenergic receptor activation is specifically mediated by Gi alpha 2.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Aorta; Binding, Competitive; Brimonidine Tartrate; Cattle; Cells, Cultured; Endothelium, Vascular; Epinephrine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Immune Sera; Kinetics; Molecular Sequence Data; Muscle, Smooth, Vascular; NAD; Nitric Oxide; Oligopeptides; Pertussis Toxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella; Yohimbine | 1993 |
High affinity platelet alpha 2-adrenergic receptor density is decreased in older humans.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adult; Aged; Aging; Blood Platelets; Brimonidine Tartrate; Dose-Response Relationship, Drug; Female; Humans; Linear Models; Male; Membranes; Middle Aged; Norepinephrine; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha | 1993 |
Noradrenaline hyperpolarizes identified rat mesopontine cholinergic neurons in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biomarkers; Brimonidine Tartrate; Dioxanes; Electric Stimulation; Idazoxan; In Vitro Techniques; Lysine; NADPH Dehydrogenase; Neurons; Norepinephrine; Pons; Potassium Channels; Quinoxalines; Rats; Receptors, Adrenergic, alpha | 1993 |
Effects of MPC-1304, a novel Ca2+ entry blocker, on alpha-adrenoceptor-mediated pressor responses in pithed rats.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Blood Pressure; Brimonidine Tartrate; Calcium Channel Blockers; Decerebrate State; Dihydropyridines; Electric Stimulation; Nifedipine; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Spinal Cord; Sympathetic Nervous System | 1993 |
Acceleration by chronic treatment with clorgyline of the turnover of brain alpha 2-adrenoceptors in normotensive but not in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brimonidine Tartrate; Cerebral Cortex; Clorgyline; Dioxanes; Down-Regulation; Hypertension; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Quinolines; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Species Specificity | 1993 |
Endogenous norepinephrine regulates tumor necrosis factor-alpha production from macrophages in vitro.
Topics: Animals; Base Sequence; Brimonidine Tartrate; Cells, Cultured; Dose-Response Relationship, Drug; Female; Isoproterenol; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred CBA; Molecular Sequence Data; Norepinephrine; Quinoxalines; Tumor Necrosis Factor-alpha; Yohimbine | 1994 |
Presynaptic alpha 2-autoreceptors in brain cortex: alpha 2D in the rat and alpha 2A in the rabbit.
Topics: Animals; Brimonidine Tartrate; Cerebral Cortex; Female; Male; Norepinephrine; Phentolamine; Quinoxalines; Rabbits; Rats; Receptors, Adrenergic, alpha; Species Specificity | 1993 |
Lysophosphatidylcholine modifies G protein-dependent signaling in porcine endothelial cells.
Topics: Adenosine Diphosphate; Animals; Bradykinin; Brimonidine Tartrate; Coronary Vessels; Dinoprost; Endothelium, Vascular; Female; Fluorides; GTP-Binding Proteins; Lysophosphatidylcholines; Male; Muscle Contraction; Pertussis Toxin; Quinoxalines; Serotonin; Signal Transduction; Swine; Virulence Factors, Bordetella | 1993 |
Comparative adrenocholinergic control of intracellular Ca2+ in the layers of the ciliary body epithelium.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Ciliary Body; Drug Combinations; Epinephrine; Epithelium; Female; Fluorescent Dyes; Fura-2; Male; Phenylephrine; Pigment Epithelium of Eye; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 1996 |
Sodium ions attenuate the inhibitory effects of neuropeptide Y on norepinephrine release in rat hypothalamus.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Hypothalamus; Male; Neuropeptide Y; Norepinephrine; Pertussis Toxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium; Virulence Factors, Bordetella | 1995 |
Involvement of alpha 2-adrenoceptors in metabolic and hormonal responses to a mixed meal in beagle dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animal Feed; Animals; Blood Glucose; Brimonidine Tartrate; Dogs; Eating; Fatty Acids, Nonesterified; Female; Glycerol; Imidazoles; Indoles; Insulin; Male; Quinoxalines; Receptors, Adrenergic, alpha | 1995 |
Dopaminergic and alpha-adrenergic control of neurotransmission in human right atrium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Benzazepines; Brimonidine Tartrate; Domperidone; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Ergolines; Female; Fenoldopam; Heart Atria; Humans; In Vitro Techniques; Male; Methoxamine; Middle Aged; Norepinephrine; Prazosin; Quinoxalines; Quinpirole; Receptors, Adrenergic, alpha; Receptors, Dopamine; Sulpiride; Synaptic Transmission; Yohimbine | 1995 |
Activation of protein kinase C as a modulator of potentiated UK-14304-induced contractions in dog mesenteric artery and vein.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Female; In Vitro Techniques; Male; Mesenteric Arteries; Mesenteric Veins; Naphthalenes; Potassium Chloride; Protein Kinase C; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction | 1995 |
Wortmannin-sensitive activation of p70s6k by endogenous and heterologously expressed Gi-coupled receptors.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Androstadienes; Animals; Brimonidine Tartrate; Enzyme Activation; GTP-Binding Proteins; Humans; Immunosuppressive Agents; Molecular Sequence Data; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Polyenes; Protein Serine-Threonine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Virulence Factors, Bordetella; Wortmannin | 1996 |
Alpha 2A-adrenergic regulation of cyclic AMP accumulation and lipolysis in human omental and subcutaneous adipocytes.
Topics: Abdomen; Adipocytes; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Brimonidine Tartrate; Cyclic AMP; Epinephrine; Female; Glycerol; Humans; Imidazoles; Isoproterenol; Lipolysis; Male; Medetomidine; Middle Aged; Omentum; Quinoxalines; Receptors, Adrenergic, alpha | 1996 |
Central hypotensive effects of the alpha2a-adrenergic receptor subtype.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Base Sequence; Blood Pressure; Brain Stem; Brimonidine Tartrate; Gene Targeting; Heart Rate; Imidazoles; Medetomidine; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Point Mutation; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1996 |
Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Benzofurans; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Imidazoles; Isotope Labeling; Male; Norepinephrine; Oxathiins; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tritium | 1996 |
Stimulation of alpha 2 adrenoceptors dilates the rat middle cerebral artery.
Topics: Animals; Arginine; Brimonidine Tartrate; Cerebral Arteries; Cerebrovascular Circulation; Dioxanes; Dose-Response Relationship, Drug; GTP-Binding Proteins; Idazoxan; Imidazoles; Male; NG-Nitroarginine Methyl Ester; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Vasodilation | 1996 |
Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenocorticotropic Hormone; Analysis of Variance; Animals; Asparagine; Aspartic Acid; Barium; Brimonidine Tartrate; Calcium Channels; Cell Line; GTP-Binding Proteins; Isoproterenol; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Pituitary Gland, Anterior; Point Mutation; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Somatostatin | 1996 |
Changes in [3H]-UK 14304 binding to alpha 2-adrenoceptors in morphine-dependent guinea-pigs.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cerebral Cortex; Dose-Response Relationship, Drug; Female; gamma-Aminobutyric Acid; Guinea Pigs; In Vitro Techniques; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2; Substance Withdrawal Syndrome; Synaptosomes; Tritium | 1995 |
Exposure and characterization of the action of noradrenaline at dopamine receptors mediating endothelium-independent relaxation of rat isolated small mesenteric arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetonitriles; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arginine; Brimonidine Tartrate; Cyclooxygenase Inhibitors; Dopamine; Dopamine Antagonists; In Vitro Techniques; Indomethacin; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenoxybenzamine; Prostaglandin Endoperoxides, Synthetic; Quinoxalines; Rats; Rats, Wistar; Receptors, Dopamine; Serotonin Antagonists; Splanchnic Circulation; Thromboxane A2; Vasoconstrictor Agents | 1995 |
Influence of adrenergic and cholinergic mediators on the equine jejunum in vitro.
Topics: Acetylcholine; Adrenergic Agonists; Adrenergic Antagonists; Animals; Atropine; Brimonidine Tartrate; Calcium Channel Blockers; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Horses; Isoproterenol; Jejunum; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxymetazoline; Parasympathetic Nervous System; Phentolamine; Phenylephrine; Prazosin; Quinoxalines; Sympathetic Nervous System; Tetrodotoxin; Verapamil; Yohimbine | 1996 |
The actions of medetomidine may not be mediated exclusively by alpha 2-adrenoceptors in the equine saphenous vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Dose-Response Relationship, Drug; Electric Stimulation; Endothelium, Vascular; Female; Horses; Imidazoles; Male; Medetomidine; Muscle Contraction; Muscle, Smooth, Vascular; Neuromuscular Junction; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Saphenous Vein; Structure-Activity Relationship | 1996 |
Cell-density-dependent expression of the beta-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Brimonidine Tartrate; Cell Count; Cells, Cultured; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Epidermal Growth Factor; Liver; Male; Metaproterenol; Quinoxalines; Rats; Rats, Wistar | 1996 |
Low concentrations of angiotensin II unmask vasoconstrictory alpha 2-adrenoceptors in isolated perfused kidneys of spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Brimonidine Tartrate; Dioxanes; Dose-Response Relationship, Drug; Hypertension; Idazoxan; Imidazoles; Kidney; Methoxamine; Perfusion; Prazosin; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction | 1995 |
Changes in the regulation of 5-hydroxytryptamine release by alpha2-adrenoceptors in the rat hippocampus after long-term desipramine treatment.
Topics: Animals; Antidepressive Agents, Tricyclic; Brimonidine Tartrate; Desipramine; Hippocampus; Male; Norepinephrine; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin | 1995 |
The presynaptic alpha-2 autoreceptors in pig brain cortex are alpha-2A.
Topics: Adrenergic alpha-Agonists; Animals; Autoreceptors; Brain; Brimonidine Tartrate; Cerebral Cortex; Kinetics; Presynaptic Terminals; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine | 1996 |
Mechanism of alpha-2 adrenergic modulation of canine cardiac Purkinje action potential.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Female; Heart; Male; Nifedipine; Purkinje Cells; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1996 |
Modulation of endothelium-derived nitric oxide in canine femoral veins.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Endothelium, Vascular; Femoral Vein; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Quinoxalines; Vasodilation; Vasodilator Agents | 1996 |
Opposite influences of hypertension and diabetes mellitus on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed rats.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Azepines; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Decerebrate State; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Male; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
Opioid desensitization: interactions with G-protein-coupled receptors in the locus coeruleus.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Drug Tolerance; Enkephalins; GTP-Binding Proteins; Locus Coeruleus; Male; Muscarine; Quinoxalines; Rats; Rats, Wistar; Receptors, Opioid, mu | 1996 |
A somatostatin receptor inhibits noradrenaline release from chick sympathetic neurons through pertussis toxin-sensitive mechanisms: comparison with the action of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Sympathetic; Hormone Antagonists; Kinetics; Membrane Potentials; Neurons; Norepinephrine; Patch-Clamp Techniques; Peptides, Cyclic; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Somatostatin; Somatostatin; Somatostatin-28; Virulence Factors, Bordetella | 1996 |
A tyrosine kinase regulates alpha-adrenoceptor-stimulated contraction and phospholipase D activation in the rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium Channel Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Genistein; Isoflavones; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pertussis Toxin; Phospholipase D; Potassium; Protein-Tyrosine Kinases; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella | 1996 |
3,4-Diaminopyridine masks the inhibition of noradrenaline release from chick sympathetic neurons via presynaptic alpha 2-adrenoceptors: insights into the role of N- and L-type calcium channels.
Topics: 4-Aminopyridine; Adrenergic alpha-Agonists; Amifampridine; Animals; Brimonidine Tartrate; Calcium Channels; Cells, Cultured; Chick Embryo; Electric Stimulation; Fluorescent Dyes; Fluorometry; Fura-2; Neurons; Norepinephrine; Potassium Channels; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Sympathetic Nervous System | 1996 |
The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a nonopioid receptor-mediated increase in K+ conductance of rat locus ceruleus neurons.
Topics: Animals; Brimonidine Tartrate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Locus Coeruleus; Male; Naloxone; Narcotics; Neurons; Nociceptin; Opioid Peptides; Peptide Fragments; Peptides; Potassium; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 1996 |
Influence of nifedipine on pressor responses induced by different alpha-adrenoceptor agonists and angiotensin II in pithed diabetic hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Blood Pressure; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Clonidine; Diabetes Mellitus, Experimental; Hypertension; Imidazoles; Nifedipine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin | 1996 |
Alpha-2 adrenoceptor subtype causing nitric oxide-mediated vascular relaxation in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Colforsin; Cyclic AMP; Endothelium, Vascular; In Vitro Techniques; Kinetics; Mesenteric Arteries; Nitric Oxide; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Swine; Vasodilation | 1996 |
Differential responses of lateral and ventrolateral rat periaqueductal grey neurones to noradrenaline in vitro.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Calcium; Cell Membrane; Electrophysiology; Lysine; Magnesium; Membrane Potentials; Neurons; Norepinephrine; Patch-Clamp Techniques; Periaqueductal Gray; Phenylephrine; Potassium; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 1996 |
Regulation of lipolysis in fat cells of obese women during long-term hypocaloric diet.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Adrenergic beta-Agonists; Adult; Brimonidine Tartrate; Bucladesine; Catecholamines; Colforsin; Dobutamine; Energy Intake; Female; Food Deprivation; Glucose; Humans; Insulin; Insulin Resistance; Isoproterenol; Lipolysis; Middle Aged; Obesity; Propanolamines; Quinoxalines; Terbutaline; Time Factors | 1996 |
Endothelium-dependent relaxation by alpha 2-adrenoceptor agonists in spontaneously hypertensive rat aorta.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Endothelium, Vascular; Hypertension; Indomethacin; Nitroarginine; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thromboxane A2; Vasodilation | 1996 |
Cell-density-dependent expression of the alpha(2)-adrenergic response by epidermal growth factor (EGF) in primary cultures of adult rat hepatocytes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Count; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Cytochalasin B; Epidermal Growth Factor; Genistein; Isoflavones; Liver; Male; Oxymetazoline; Pertussis Toxin; Protein Biosynthesis; Proteins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella; Yohimbine | 1996 |
Imidazoline compounds stimulate insulin release by inhibition of K(ATP) channels and interaction with the exocytotic machinery.
Topics: Animals; Brimonidine Tartrate; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytosol; Diazoxide; Exocytosis; Glucose; Idazoxan; Imidazoles; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Membrane Potentials; Phentolamine; Potassium Channels; Potassium Chloride; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Tumor Cells, Cultured | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brimonidine Tartrate; Cyclic AMP; Diabetes Mellitus, Experimental; Dinoprostone; Galanin; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Quinoxalines; Rats; Rats, Wistar; Secretory Rate; Somatostatin | 1996 |
Clonidine-induced increase in osmolar clearance and free water clearance via activation of two distinct alpha 2-adrenoceptor sites.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Male; Naltrexone; Osmolar Concentration; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Water | 1996 |
Characterization of brimonidine metabolism with rat, rabbit, dog, monkey and human liver fractions and rabbit liver aldehyde oxidase.
Topics: Acetates; Adult; Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Brimonidine Tartrate; Chromatography, Liquid; Dogs; Guanidine; Guanidines; Haplorhini; Humans; Liver; Male; Mass Spectrometry; Quinoxalines; Rabbits; Rats; Species Specificity | 1996 |
Alterations in the central nervous alpha 2-adrenoceptor system under chronic psychosocial stress.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Chronic Disease; Down-Regulation; Hydrocortisone; Idazoxan; Locus Coeruleus; Male; Nerve Tissue Proteins; Norepinephrine; Oxymetazoline; Pituitary-Adrenal System; Prefrontal Cortex; Quinoxalines; Receptors, Adrenergic, alpha-2; Social Dominance; Solitary Nucleus; Stress, Psychological; Tupaiidae; Up-Regulation; Vagus Nerve | 1996 |
Characterization of alpha-adrenoceptor subtype(s) mediating vasoconstriction in the perfused rabbit ovarian vascular bed.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dose-Response Relationship, Drug; Electric Stimulation; Female; Ovary; Oxidopamine; Perfusion; Prazosin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction | 1996 |
A simple method for measuring the effects of drugs on intestinal longitudinal and circular muscle.
Topics: Animals; Atropine; Brimonidine Tartrate; Clonidine; Electric Stimulation; Female; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Wistar; Tetrodotoxin | 1996 |
Alpha-2 adrenoceptor blockade protects rats against lipopolysaccharide.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Creatinine; Escherichia coli; Hemodynamics; Lipopolysaccharides; Lung; Male; Peroxidase; Quinoxalines; Rats; Rats, Sprague-Dawley; Survival Rate; Tumor Necrosis Factor-alpha; Xylazine; Yohimbine | 1996 |
Acetylcholine release in the rat prefrontal cortex in vivo: modulation by alpha 2-adrenoceptor agonists and antagonists.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Guanabenz; Idazoxan; Imidazoles; Male; Microdialysis; Piperoxan; Prefrontal Cortex; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley | 1997 |
Synthesis and evaluation of 2-(arylamino)imidazoles as alpha 2-adrenergic agonists.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blood-Brain Barrier; Brimonidine Tartrate; Imidazoles; Intraocular Pressure; Macaca fascicularis; Quinoxalines; Rabbits | 1997 |
Effects of UK-14,304, noradrenaline, and propranolol on insulin release from transplanted mouse islets.
Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Brimonidine Tartrate; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred BALB C; Norepinephrine; Perfusion; Propranolol; Quinoxalines; Time Factors | 1996 |
Interactions of the alpha2A-adrenoceptor with multiple Gi-family G-proteins: studies with pertussis toxin-resistant G-protein mutants.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Antibodies; Blotting, Western; Brimonidine Tartrate; Cloning, Molecular; COS Cells; Gene Expression Regulation; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Transfection; Virulence Factors, Bordetella | 1997 |
Adrenergic responses in silent and putative inhibitory pacemaker-like neurons of the rat rostral ventrolateral medulla in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Bicuculline; Biological Clocks; Brimonidine Tartrate; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine Agents; Interneurons; Ion Channel Gating; Isoproterenol; Medulla Oblongata; Norepinephrine; Prazosin; Quinoxalines; Rats; Rats, Wistar; Strychnine; Synaptic Transmission; Tetrodotoxin; Yohimbine | 1997 |
Do cardiovascular mechanisms participate in thermoregulatory activity of alpha 2-adrenoceptor agonists and antagonists in rabbits?
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Benzazepines; Body Temperature; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Ear; Energy Metabolism; Fever; Hemodynamics; Lipopolysaccharides; Male; Pyrogens; Quinoxalines; Rabbits; Yohimbine | 1997 |
Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
Topics: Adrenergic alpha-Agonists; Animals; Body Water; Brimonidine Tartrate; Guanfacine; Idazoxan; Kidney; Male; Naltrexone; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1997 |
Interaction between histamine H3 receptors and other prejunctional receptor systems in the isolated guinea pig duodenum.
Topics: Acetylcholine; Adenosine; Animals; Brimonidine Tartrate; Duodenum; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Methylhistamines; Muscle Contraction; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Histamine H3; Receptors, Purinergic P1 | 1997 |
New agents for the treatment of glaucoma.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines | 1997 |
Influence of prolonged fasting and thyroid hormone on the alpha 2-adrenergic response in isolated epididymal adipocytes of Wistar rats.
Topics: Adipocytes; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Separation; Epididymis; Fasting; Idazoxan; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Time Factors; Triiodothyronine | 1997 |
VB20B7, a novel 5-HT-ergic agent with gastrokinetic activity. II. Evaluation of the gastroprokinetic activity in rats and dogs.
Topics: Animals; Antiemetics; Benzothiazoles; Body Temperature; Brimonidine Tartrate; Dogs; Female; Ferrets; Gastric Emptying; Gastrointestinal Agents; Male; Mice; Motor Activity; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Serotonin; Thiazoles | 1997 |
Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine | 1997 |
Role of alpha 2-adrenoceptors in the regulation of intestinal water transport.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Biological Transport; Brimonidine Tartrate; Dose-Response Relationship, Drug; Female; Ileum; Imidazoles; Indoles; Intestinal Absorption; Isoindoles; Isoquinolines; Jejunum; Male; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Vasoactive Intestinal Peptide; Water; Yohimbine | 1997 |
Cardiovascular effects of oxymetazoline and UK14,304 in conscious and pithed rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Brimonidine Tartrate; Cardiovascular System; Decerebrate State; Electric Stimulation; Heart Rate; Male; Oxymetazoline; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1997 |
Variation in adrenergic regulation of lipolysis between omental and subcutaneous adipocytes from obese and non-obese men.
Topics: Adipocytes; Adipose Tissue; Adrenergic Agonists; Adult; Biopsy; Brimonidine Tartrate; Dobutamine; Dose-Response Relationship, Drug; Humans; Lipolysis; Male; Middle Aged; Norepinephrine; Obesity; Omentum; Propanolamines; Quinoxalines; Receptors, Adrenergic; Skin; Terbutaline | 1997 |
HepG2 and SK-N-MC: two human models to study alpha-2 adrenergic receptors of the alpha-2C subtype.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Cyclic AMP; GTP-Binding Proteins; Humans; Models, Biological; Polymerase Chain Reaction; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured | 1997 |
ATP-sensitive potassium channels mediate contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Female; Femoral Artery; Humans; Muscle Contraction; Muscle, Skeletal; Potassium Channels; Quinoxalines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sympathetic Nervous System; Vasoconstriction | 1997 |
A comparative study of alpha2- and beta-adrenoceptor distribution in pigeon and chick brain.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Brain; Brimonidine Tartrate; Chickens; Columbidae; Male; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Tissue Distribution | 1997 |
Histamine H3 receptors do not modulate reflex-evoked peristaltic motility in the isolated guinea-pig ileum.
Topics: Animals; Brimonidine Tartrate; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Perfusion; Peristalsis; Quinoxalines; Receptors, Histamine H3; Reflex | 1997 |
Brimonidine--an alpha 2-agonist for glaucoma.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Clinical Trials as Topic; Contraindications; Glaucoma; Humans; Intraocular Pressure; Quinoxalines; Xerostomia | 1997 |
Discriminative stimulus properties of cocaine: enhancement by beta-adrenergic receptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Benzofurans; Betaxolol; Brimonidine Tartrate; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug Synergism; Imidazoles; Male; Nadolol; Narcotics; Propanolamines; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Thiophenes | 1997 |
Functional consequences of constitutively active alpha2A-adrenergic receptor expression in 3T3F442A preadipocytes and adipocytes.
Topics: 3T3 Cells; Adipocytes; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Culture Media, Serum-Free; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Idazoxan; Kinetics; Lipolysis; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Sodium Chloride; Transfection | 1997 |
An arginine analog inhibits responses of both the endothelium and smooth muscle of canine in situ vein grafts.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Calcimycin; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Femoral Artery; Femoral Vein; Graft Occlusion, Vascular; Ionophores; Male; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Organ Culture Techniques; Quinoxalines; Vascular Resistance; Veins | 1997 |
Existence of dopamine D1 receptor on the sympathetic nerve endings in the guinea-pig vas deferens.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Dopamine Agonists; Dopamine Antagonists; Electric Stimulation; Guinea Pigs; Idazoxan; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Presynaptic Terminals; Quinoxalines; Receptors, Dopamine D1; Spiperone; Synaptic Transmission; Vas Deferens | 1997 |
Activation of alpha-2 adrenergic receptors inhibits norepinephrine release by a pertussis toxin-insensitive pathway independent of changes in cytosolic calcium in cultured rat sympathetic neurons.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Cells, Cultured; Cyclic AMP; Norepinephrine; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Superior Cervical Ganglion; Virulence Factors, Bordetella | 1997 |
Measurement of agonist-induced guanine nucleotide turnover by the G-protein Gi1alpha when constrained within an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Brimonidine Tartrate; Cell Membrane; COS Cells; DNA Primers; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Polymerase Chain Reaction; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Swine; Transfection | 1997 |
Efficacy and kinetics of opioid action on acutely dissociated neurons.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Locus Coeruleus; Morphine; Narcotics; Potassium Channels; Quinoxalines | 1997 |
Nitric oxide inhibition simulates the enhancement of alpha 1 agonist-induced vasoconstriction in diabetes.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Diabetes Mellitus, Experimental; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Vasoconstriction | 1997 |
Mechanisms of adrenergic agonist induced allergy bioactivation and antigen formation.
Topics: Adrenergic alpha-Agonists; Allergens; Amodiaquine; Brimonidine Tartrate; Clonidine; Epinephrine; Glutathione; Horseradish Peroxidase; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Quinoxalines | 1997 |
Subtype determination of soma-dendritic alpha2-autoreceptors in slices of rat locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Brimonidine Tartrate; Dendrites; In Vitro Techniques; Locus Coeruleus; Maprotiline; Neurons; Norepinephrine; Phentolamine; Prazosin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Yohimbine | 1997 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic | 1997 |
The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy.
Topics: Adrenergic alpha-Agonists; Analgesics; Anesthesia, Spinal; Animals; Behavior, Animal; Brimonidine Tartrate; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hot Temperature; Mice; Mice, Inbred C57BL; Morphine; Nociceptors; Pain Measurement; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P | 1997 |
Alpha-adrenoceptors in equine digital veins: evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Dopamine; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Veins; Yohimbine | 1997 |
Expression of functional alpha2-adrenergic receptor subtypes in human corpus cavernosum and in cultured trabecular smooth muscle cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Penis; Quinoxalines; Radioisotopes; Receptors, Adrenergic, alpha-2; Ribonucleases; RNA, Messenger; Yohimbine | 1997 |
The slope parameter of concentration-response curves used as a touchstone for the existence of spare receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Brimonidine Tartrate; Cerebral Cortex; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Models, Theoretical; Norepinephrine; Quinolines; Quinoxalines; Rats | 1997 |
Rescue of functional interactions between the alpha2A-adrenoreceptor and acylation-resistant forms of Gi1alpha by expressing the proteins from chimeric open reading frames.
Topics: Acylation; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; COS Cells; GTP-Binding Proteins; Open Reading Frames; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Swine | 1997 |
Modulation of Ca2+ currents by various G protein-coupled receptors in sympathetic neurons of male rat pelvic ganglia.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium Channels; Ganglia, Sympathetic; GTP-Binding Proteins; Hypogastric Plexus; Male; Membrane Potentials; Muscarine; Muscarinic Agonists; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Wistar; Receptors, Neurotransmitter; Superior Cervical Ganglion; Vasoactive Intestinal Peptide | 1997 |
Regional differences in adipose tissue metabolism between sedentary and endurance-trained women.
Topics: Abdomen; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adult; Analysis of Variance; Brimonidine Tartrate; Bucladesine; Cells, Cultured; Colforsin; Epinephrine; Exercise Test; Female; Humans; Life Style; Lipolysis; Lipoprotein Lipase; Oxygen Consumption; Physical Endurance; Physical Fitness; Quinoxalines; Regression Analysis; Respiration; Skin; Thigh | 1997 |
Proliferation of adult rat hepatocytes by hepatocyte growth factor is potentiated by both phenylephrine and metaproterenol.
Topics: Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Cell Division; Cells, Cultured; Cyclic AMP; Dexamethasone; DNA; Dose-Response Relationship, Drug; Drug Synergism; Hepatocyte Growth Factor; Isoquinolines; Liver; Male; Metaproterenol; Phenylephrine; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Sulfonamides | 1997 |
Alpha-adrenoceptor-mediated prejunctional effects of chloroethylclonidine in the canine saphenous vein.
Topics: Adrenergic alpha-Antagonists; Animals; Autoreceptors; Brimonidine Tartrate; Clonidine; Dogs; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Saphenous Vein; Yohimbine | 1997 |
Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Azepines; Brimonidine Tartrate; Clonidine; Cognition; Discrimination, Psychological; Guanfacine; Haplorhini; Memory; Norepinephrine; Quinoxalines; Reaction Time; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Visual Perception | 1998 |
Nonneuronal dopamine.
Topics: Adrenergic alpha-Agonists; Amiloride; Animals; Benserazide; Biological Transport; Brimonidine Tartrate; Catechol O-Methyltransferase; Dopamine; Kidney; Kidney Cortex; Kidney Tubules; Levodopa; Models, Biological; Monoamine Oxidase; Phenylephrine; Quinoxalines; Sodium-Hydrogen Exchangers | 1998 |
Noradrenaline release from rat sympathetic neurones triggered by activation of B2 bradykinin receptors.
Topics: Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Cadmium; Calcium; Cells, Cultured; In Vitro Techniques; Neurotransmitter Agents; Norepinephrine; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Bradykinin B2; Receptors, Adrenergic, alpha-2; Receptors, Bradykinin; Superior Cervical Ganglion; Tetrodotoxin; Thapsigargin | 1997 |
Insulin enhances endothelial alpha2-adrenergic vasorelaxation by a pertussis toxin mechanism.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Insulin; Male; omega-N-Methylarginine; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Vasodilation; Virulence Factors, Bordetella | 1997 |
Gender differences in endothelium-dependent relaxations do not involve NO in porcine coronary arteries.
Topics: Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Calcimycin; Cholesterol; Coronary Vessels; Endothelium, Vascular; Estradiol; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Lipoproteins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Ovariectomy; Progesterone; Prostaglandins; Quinoxalines; Sex Characteristics; Sexual Maturation; Swine; Testosterone | 1997 |
Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adrenergic alpha-Agonists; Animals; Astrocytes; Brimonidine Tartrate; Carcinogens; Cell Fractionation; Cell Membrane; Cerebral Cortex; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Idazoxan; Male; Pertussis Toxin; Phenylisopropyladenosine; Quinoxalines; Rats; Rats, Wistar; Saccharin; Signal Transduction; Swine; Taste; Thyroid Gland; Virulence Factors, Bordetella | 1997 |
Involvement of alpha-2 adrenoceptors in the effects of moxonidine on intestinal motility and fluid transport.
Topics: Adrenergic alpha-2 Receptor Agonists; Agmatine; Animals; Body Water; Brimonidine Tartrate; Dose-Response Relationship, Drug; Gastrointestinal Motility; Imidazoles; Male; Peristalsis; Quinolines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Vasoactive Intestinal Peptide; Yohimbine | 1997 |
Interaction of the renin-angiotensin system, bradykinin and sympathetic nerves with cholinergic transmission in the rat isolated trachea.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Brimonidine Tartrate; Epithelium; Female; Idazoxan; In Vitro Techniques; Indoles; Indomethacin; Male; Neprilysin; Nitroarginine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Renin-Angiotensin System; Sympathetic Nervous System; Trachea | 1997 |
Rat group I metabotropic glutamate receptors inhibit neuronal Ca2+ channels via multiple signal transduction pathways in HEK 293 cells.
Topics: Animals; Brimonidine Tartrate; Calcium Channels; Calcium Channels, N-Type; Cell Line; Female; Glutamic Acid; GTP-Binding Proteins; Humans; In Vitro Techniques; Kidney; Neurons; Pertussis Toxin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recombinant Proteins; Signal Transduction; Superior Cervical Ganglion; Transfection; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1998 |
Increased vascular responsiveness to alpha 2-adrenergic stimulation during NOS inhibition-induced hypertension.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Brimonidine Tartrate; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Phenylephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Systole; Vasoconstriction; Yohimbine | 1997 |
Regulation of adenylyl cyclase in polarized renal epithelial cells by G protein-coupled receptors.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Line; Cell Membrane; Cell Polarity; Colforsin; Cyclic AMP; Epithelial Cells; Gene Expression Regulation; GTP-Binding Proteins; Kidney; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P1; Recombinant Proteins; Transfection | 1997 |
Voltage-dependent calcium currents in bulbospinal neurons of neonatal rat rostral ventrolateral medulla: modulation by alpha2-adrenergic receptors.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Brimonidine Tartrate; Calcium; Calcium Channels; Calcium Channels, L-Type; Dihydropyridines; Fluorescent Dyes; Ion Channel Gating; Medulla Oblongata; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Prazosin; Propranolol; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Spider Venoms; Tyrosine 3-Monooxygenase | 1998 |
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding, Competitive; Brain Chemistry; Brimonidine Tartrate; Cell Membrane; Clonidine; Depression; Female; Frontal Lobe; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Suicide; Tritium | 1998 |
alpha2-Adrenoceptor-mediated potassium currents in acutely dissociated rat locus coeruleus neurones.
Topics: 4-Aminopyridine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Membrane Permeability; Cells, Cultured; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Isoquinolines; Kinetics; Locus Coeruleus; Membrane Potentials; Neurons; Nystatin; Patch-Clamp Techniques; Piperazines; Potassium; Potassium Channel Blockers; Potassium Channels; Prazosin; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Thionucleotides; Yohimbine | 1998 |
Alpha2C-adrenoceptors mediate inhibition of forskolin-stimulated cAMP production in rat striatum.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Colforsin; Corpus Striatum; Cyclic AMP; Functional Laterality; In Vitro Techniques; Kinetics; Male; Oligonucleotides, Antisense; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; RNA, Messenger; Transcription, Genetic | 1997 |
Alpha 2-adrenergic receptor activation inhibits calcitonin gene-related peptide expression in cultured dorsal root ganglia neurons.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Cells, Cultured; Drug Combinations; Ganglia, Spinal; Male; Nerve Growth Factors; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1998 |
Regulation of stimulated cyclic AMP synthesis by urocanic acid.
Topics: Adrenergic alpha-Agonists; Alprostadil; Animals; Brimonidine Tartrate; Cells, Cultured; Colon; Cricetinae; Cyclic AMP; Dinoprostone; Epinephrine; Fibroblasts; Histamine; HT29 Cells; Humans; Liver; Mesocricetus; Quinoxalines; Urocanic Acid | 1998 |
Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Adipocytes; Adult; Animals; Brimonidine Tartrate; Cell Differentiation; Cell Division; Cells, Cultured; Culture Techniques; Female; Humans; Idazoxan; Lysophospholipids; Mice; Paracrine Communication; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1998 |
Intracellular signaling pathways confer specificity of transactivation by mineralocorticoid and glucocorticoid receptors.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Line; Enzyme Inhibitors; Epithelial Cells; Growth Substances; Kidney; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Quinoxalines; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Receptors, Thyroid Hormone; Signal Transduction; Swine; Transcription, Genetic; Transcriptional Activation | 1998 |
The expression of functional postsynaptic alpha2-adrenoceptors in the corpus cavernosum smooth muscle.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Cyclic AMP; Male; Muscle Contraction; Muscle, Smooth; Oxymetazoline; Penis; Phenylephrine; Prazosin; Quinoxalines; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Second Messenger Systems; Synapses; Tritium; Yohimbine | 1998 |
Alpha-adrenoceptor subtypes of dog saphenous vein: another unusual property.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Dogs; Female; Fluorescence; Fura-2; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Phenylephrine; Potassium Chloride; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Saphenous Vein; Signal Transduction; Yohimbine | 1998 |
Characteristics of adrenoceptors in the human radial artery: clinical implications.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Brimonidine Tartrate; Coronary Artery Bypass; Coronary Vessels; Endothelium, Vascular; Humans; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Quinoxalines; Radial Artery; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Swine; Vasoconstriction | 1998 |
Dietary sodium restriction impairs endothelial effect of insulin.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Data Interpretation, Statistical; Diet, Sodium-Restricted; Endothelium, Vascular; Glucose; Glucose Clamp Technique; In Vitro Techniques; Insulin; Male; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sodium Chloride, Dietary; Vasodilation | 1998 |
Evidence for supraspinal nervous control of external anal sphincter motility in the cat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anal Canal; Animals; Blood Pressure; Brimonidine Tartrate; Cats; Clonidine; Efferent Pathways; Electric Stimulation; Electromyography; Enkephalin, Leucine; Female; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Locus Coeruleus; Male; Morphine; Narcotics; Nicergoline; Norepinephrine; Peripheral Nerves; Phenylephrine; Prazosin; Quinoxalines; Reflex; Spinal Cord | 1998 |
Heterogeneous effects of rapid eye movement sleep deprivation on binding to alpha- and beta-adrenergic receptor subtypes in rat brain.
Topics: Animals; Autoradiography; Brain; Brimonidine Tartrate; Iodine Radioisotopes; Kinetics; Male; Organ Specificity; Pindolol; Prazosin; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sleep Deprivation; Sleep, REM; Tritium | 1998 |
Effects of the alkylating agent EEDQ on regulatory G proteins and recovery of agonist and antagonist alpha2-adrenoceptor binding sites in rat brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Brimonidine Tartrate; Cerebral Cortex; GTP-Binding Proteins; Idazoxan; Male; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley | 1998 |
Prejunctional alpha2-adrenoceptors and peroxide-induced potentiation of norepinephrine release from the bovine iris.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Fibers; Animals; Brimonidine Tartrate; Cattle; Clonidine; Culture Techniques; Hydrogen Peroxide; Iris; Neuroeffector Junction; Norepinephrine; Oxymetazoline; Perfusion; Quinoxalines; Reactive Oxygen Species; Receptors, Adrenergic, alpha-2; Synaptic Transmission; Tritium; Yohimbine | 1998 |
Hydrophobicity of residue351 of the G protein Gi1 alpha determines the extent of activation by the alpha 2A-adrenoceptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Brimonidine Tartrate; Cell Line; Cysteine; Glycine; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Kidney; Molecular Sequence Data; Mutagenesis, Site-Directed; Pertussis Toxin; Protein Binding; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Transfection; Virulence Factors, Bordetella | 1998 |
Brimonidine and pupillary diameter.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Dose-Response Relationship, Drug; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Pupil; Quinoxalines; Safety | 1998 |
Alpha2-adrenoceptor-mediated contractions of the porcine isolated ear artery: evidence for a cyclic AMP-dependent and a cyclic AMP-independent mechanism.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Angiotensin II; Animals; Arteries; Brimonidine Tartrate; Colforsin; Cyclic AMP; Ear; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Nitroprusside; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine | 1998 |
Differential coupling of alpha1-, alpha2-, and beta-adrenergic receptors to mitogen-activated protein kinase pathways and differentiation in transfected PC12 cells.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Colforsin; Enzyme Activation; Inositol Phosphates; Isopropyl Thiogalactoside; JNK Mitogen-Activated Protein Kinases; Kinetics; Mitogen-Activated Protein Kinases; Nerve Growth Factors; Norepinephrine; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Recombinant Proteins; Signal Transduction; Transfection | 1998 |
Update in glaucoma: the new pharmacotherapies. Brimonidine versus apraclonidine.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Clonidine; Glaucoma; Humans; Quinoxalines | 1998 |
[New drugs in glaucoma therapy].
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clonidine; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome | 1998 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
Prejunctional control of pH 6-induced bronchoconstriction by NK1, NK2, mu-opioid, alpha2-adrenoceptor and glucocorticoid receptors in guinea-pig isolated perfused lung.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Benzamides; Betamethasone; Biphenyl Compounds; Brimonidine Tartrate; Bronchoconstriction; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Lung; Male; Morphine; Neurokinin-1 Receptor Antagonists; Perfusion; Piperidines; Quinoxalines; Quinuclidines; Receptors, Adrenergic, alpha-2; Receptors, Cell Surface; Receptors, Glucocorticoid; Receptors, Neurokinin-2; Receptors, Opioid, mu | 1998 |
Effects of insulin-like growth factor I and II on DNA synthesis and proliferation in primary cultures of adult rat hepatocytes.
Topics: Animals; Brimonidine Tartrate; Cell Count; Cell Division; Cyclic AMP; DNA; Dose-Response Relationship, Drug; Drug Interactions; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Isoquinolines; Liver; Male; Metaproterenol; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
Alpha2-adrenoceptors mediate the effect of dopamine on adult rat jejunal electrolyte transport.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Amiloride; Animals; Brimonidine Tartrate; Bucladesine; Cardiotonic Agents; Colforsin; Diuretics; Dopamine; Dose-Response Relationship, Drug; Electric Impedance; Electrolytes; Furosemide; Ion Transport; Jejunum; Male; Ouabain; Phentolamine; Prazosin; Propranolol; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2 | 1998 |
Loss of activation of Gs but not Gi following expression of an alpha2A-adrenoceptor-Gi1alpha fusion protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Binding Sites; Brimonidine Tartrate; Cholera Toxin; Colforsin; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Oxymetazoline; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Virulence Factors, Bordetella | 1998 |
Rilmenidine reveals differences in the pharmacological characteristics of prejunctional alpha2-adrenoceptors in the guinea-pig, rat and pig.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle Contraction; Oxazoles; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Rilmenidine; Species Specificity; Swine; Vas Deferens | 1998 |
Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Biological Transport; Brimonidine Tartrate; Clonidine; Cyclopropanes; Desipramine; Drug Administration Schedule; gamma-Aminobutyric Acid; Hippocampus; Hypothalamus; Injections, Subcutaneous; Kinetics; Locus Coeruleus; Lysergic Acid Diethylamide; Male; Mesencephalon; Milnacipran; Neurons; Norepinephrine; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Spiperone; Time Factors | 1998 |
Pharmacological evidence for different alpha 2-adrenergic receptor sites mediating analgesia and sedation in the rat.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesia; Analgesics, Non-Narcotic; Animals; Brimonidine Tartrate; Clonidine; Conscious Sedation; Hypnotics and Sedatives; Imidazoles; Injections, Intraventricular; Injections, Spinal; Male; Medetomidine; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine | 1998 |
A yohimbine-dependent, UK14,304 induced ion transient in HT29 cells studied by X-ray microanalysis.
Topics: Brimonidine Tartrate; Calcium; Chlorides; Electron Probe Microanalysis; HT29 Cells; Humans; Intestinal Mucosa; Ion Transport; Quinoxalines; Receptors, Adrenergic, alpha-2; Sodium; Yohimbine | 1996 |
Role of alpha2-adrenoceptors on the hyperglycaemic and insulin secretory effects derived from alpha1- and beta-adrenoceptor stimulation in the rabbit.
Topics: Adrenergic alpha-Agonists; Albuterol; Animals; Blood Glucose; Blood Pressure; Brimonidine Tartrate; Clonidine; Ethanolamines; Heart Rate; Hyperglycemia; Insulin; Insulin Secretion; Lactic Acid; Male; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta | 1998 |
Presynaptic inhibition by concanavalin A: are alpha-latrotoxin receptors involved in action potential-dependent transmitter release?
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Cattle; Chickens; Concanavalin A; Electric Stimulation; Electrophysiology; Neural Inhibition; Neurons; Neurotransmitter Agents; Norepinephrine; Presynaptic Terminals; Quinoxalines; Receptors, Peptide; Sympathetic Nervous System | 1998 |
Inhibition by midazolam of the adrenergic function in the isolated canine mesenteric vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Antagonists; Animals; Anti-Anxiety Agents; Brimonidine Tartrate; Calcium; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrochemistry; Female; Male; Mesenteric Veins; Midazolam; Muscle, Smooth, Vascular; Nerve Endings; Norepinephrine; Phenylephrine; Quinoxalines; Receptors, Adrenergic, alpha; Tetrodotoxin; Vasoconstrictor Agents; Vasodilator Agents; Yohimbine | 1998 |
Insights into the unusual alpha adrenoceptor subtype in dog saphenous vein using phenoxybenzamine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Alkylation; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Phenoxybenzamine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-2; Saphenous Vein; Yohimbine | 1999 |
Impaired function of alpha-2 adrenoceptors in smooth muscle of mesenteric arteries from spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apamin; Biological Factors; Brimonidine Tartrate; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; In Vitro Techniques; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Prazosin; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2 | 1998 |
[Modern anti-glaucoma drugs and their secondary effects].
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Dinoprost; Glaucoma; Humans; Quinoxalines; Sulfonamides; Thiophenes | 1998 |
Lysophosphatidylcholine potentiates vascular contractile responses by enhancing vasoconstrictor-induced increase in cytosolic free Ca2+ in rat aorta.
Topics: Animals; Aorta; Brimonidine Tartrate; Calcium; Cytosol; Enzyme Inhibitors; Lysophosphatidylcholines; Male; Naphthalenes; Nicardipine; Norepinephrine; Potassium Chloride; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 1998 |
Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration.
Topics: Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Axons; Brimonidine Tartrate; Cell Count; Cell Survival; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Male; Nerve Degeneration; Neuroprotective Agents; Optic Nerve; Optic Nerve Diseases; Optic Nerve Injuries; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Retinal Ganglion Cells; Timolol; Yohimbine | 1999 |
Receptor selectivity of the cloned opossum G protein-coupled receptor kinase 2 (GRK2) in intact opossum kidney cells: role in desensitization of endogenous alpha2C-adrenergic but not serotonin 1B receptors.
Topics: Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Base Sequence; beta-Adrenergic Receptor Kinases; Blotting, Northern; Brimonidine Tartrate; Cell Line; Cloning, Molecular; Colforsin; Cyclic AMP-Dependent Protein Kinases; G-Protein-Coupled Receptor Kinase 2; Kidney; Molecular Sequence Data; Mutation; Opossums; Quinoxalines; Rats; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Recombinant Proteins; Sequence Homology, Amino Acid | 1999 |
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1999 |
Modulation of relative intrinsic activity of agonists at the alpha-2A adrenoceptor by mutation of residue 351 of G protein gi1alpha.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; COS Cells; Cysteine; Dose-Response Relationship, Drug; Epinephrine; Glycine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gi-Go; Point Mutation; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Swine; Yohimbine | 1999 |
Ultrabiomicroscopic study of the effects of brimonidine, apraclonidine, latanoprost and ibopamine on the chamber angle and ciliary body.
Topics: Adrenergic alpha-Agonists; Aged; Anterior Chamber; Brimonidine Tartrate; Ciliary Body; Clonidine; Deoxyepinephrine; Female; Follow-Up Studies; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Mydriatics; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Reference Values; Ultrasonography | 1998 |
Pupillographic, tonographic and refractive parameter changes after topical instillation of Brimonidine tartrate 0.2% in healthy subjects.
Topics: Accommodation, Ocular; Administration, Topical; Adrenergic alpha-Agonists; Adult; Aqueous Humor; Brimonidine Tartrate; Female; Follow-Up Studies; Humans; Intraocular Pressure; Male; Pupil; Quinoxalines; Reference Values; Refraction, Ocular; Tonometry, Ocular | 1998 |
Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dose-Response Relationship, Drug; Epidermis; Foot; In Vitro Techniques; Ligation; Lumbosacral Region; Macaca fascicularis; Nerve Fibers; Nociceptors; Peroneal Nerve; Phenylephrine; Quinoxalines; Sensory Thresholds; Spinal Nerves | 1999 |
Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Carcinoma, Hepatocellular; Humans; Idazoxan; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tritium; Tumor Cells, Cultured | 1999 |
Effects of pituitary adenylate cyclase activating polypeptide-27 (PACAP) and vasoactive intestinal polypeptide (VIP) on chloride in HT29 cells studied by X-ray microanalysis.
Topics: Adenylate Cyclase Toxin; Alloxan; Brimonidine Tartrate; Chloride Channels; Chlorides; Egtazic Acid; Electron Probe Microanalysis; Estrenes; HT29 Cells; Humans; Microscopy, Electron, Scanning Transmission; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium; Pyrrolidinones; Quinoxalines; Signal Transduction; Somatostatin; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1999 |
The effect of latanoprost and brimonidine on rabbit subconjunctival fibroblasts.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Count; Cell Division; Conjunctiva; Disease Models, Animal; Fibroblasts; Glaucoma; Intraocular Pressure; Latanoprost; Microfilament Proteins; Ophthalmic Solutions; Proliferating Cell Nuclear Antigen; Prostaglandins F, Synthetic; Quinoxalines; Rabbits | 1999 |
[Four new drugs for glaucoma: apraclonidine, brimonidine, dorzolamide and latanoprost].
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Clonidine; Drug Approval; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Netherlands; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes | 1999 |
[Signal transduction of serotonin release from enterochromaffin cells in mouse ileal crypts].
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Clonidine; Enterochromaffin Cells; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Norepinephrine; Phosphodiesterase Inhibitors; Prazosin; Pyrrolidinones; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Rolipram; Serotonin; Signal Transduction; Yohimbine | 1998 |
Development of an HPLC method for determining the alpha 2-adrenergic receptor agonist brimonidine in blood serum and aqueous humor of the eye.
Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Brimonidine Tartrate; Chromatography, High Pressure Liquid; Humans; Male; Quinoxalines; Receptors, Adrenergic, alpha-2; Spectrophotometry, Ultraviolet | 1999 |
G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; COS Cells; GTP-Binding Proteins; Humans; Idazoxan; Inositol Phosphates; Mice; Mutation; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 1999 |
The alpha2A-adrenergic receptor discriminates between Gi heterotrimers of different betagamma subunit composition in Sf9 insect cell membranes.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Biopolymers; Brimonidine Tartrate; Cell Membrane; GTP-Binding Protein alpha Subunits, Gi-Go; Molecular Sequence Data; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Spodoptera | 1999 |
Alpha2-adrenergic agonist modulation of [35S]GTPgammaS binding to guanine-nucleotide-binding-proteins in human platelet membranes.
Topics: Adrenergic alpha-Agonists; Blood Platelets; Brimonidine Tartrate; Cell Membrane; Cyclic AMP; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Kinetics; Quinoxalines; Sodium Chloride; Sulfur Radioisotopes | 1999 |
Alpha2-adrenoceptor modulation of cortical acetylcholine release in vivo.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Benzylamines; Brimonidine Tartrate; Cerebellum; Cerebral Cortex; Epinephrine; Globus Pallidus; Imidazoles; In Vitro Techniques; Kinetics; Parietal Lobe; Prefrontal Cortex; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Substantia Innominata; Sympathomimetics | 1999 |
A study of NPY-mediated contractions of the porcine isolated ear artery.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Angiotensin II; Animals; Brimonidine Tartrate; Colforsin; Cyclic AMP; Ear, External; In Vitro Techniques; Isometric Contraction; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuropeptide Y; Nitroprusside; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Neuropeptide Y; Regional Blood Flow; Swine; Vasoconstrictor Agents; Vasodilator Agents | 1999 |
Functional alpha2C-adrenoceptors in human neuroblastoma SH-SY5Y cells.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Guanfacine; Humans; Idazoxan; Isoquinolines; Neuroblastoma; Oxymetazoline; Piperazines; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Yohimbine | 1999 |
Inhibitory effects of adrenaline on the release of noradrenaline from sympathetic nerves in human dental pulp.
Topics: Adolescent; Adrenergic Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Adult; Brimonidine Tartrate; Culture Techniques; Dental Pulp; Desipramine; Epinephrine; Humans; Norepinephrine; Quinoxalines; Radiopharmaceuticals; Receptors, Presynaptic; Sympathetic Nervous System; Tritium; Yohimbine | 1999 |
Importance of agonists in alpha-adrenoceptor classification and localisation of alpha1-adrenoceptors in human prostate.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Brimonidine Tartrate; Calcium; Carotid Artery, Common; Cells, Cultured; Fibroblasts; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Prazosin; Prostate; Quinoxalines; Rabbits; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Saphenous Vein | 1999 |
Postjunctional alpha2-adrenoceptors in the rat tail artery: effect of sex and castration.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Castration; Female; Gonadal Steroid Hormones; Male; Norepinephrine; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha-2; Sex Characteristics; Tail; Vasoconstrictor Agents | 1999 |
Mechanisms of noradrenaline-induced vasorelaxation in isolated femoral arteries of the neonatal rat.
Topics: Animals; Animals, Newborn; Brimonidine Tartrate; Femoral Artery; In Vitro Techniques; Nitric Oxide; Norepinephrine; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Vasodilation | 1999 |
Systemic adverse effects of topical treatment with brimonidine in an infant with secondary glaucoma.
Topics: Adrenergic alpha-Agonists; Blood-Brain Barrier; Brimonidine Tartrate; Central Nervous System; Glaucoma; Humans; Infant; Quinoxalines | 1999 |
GABA(B), opioid and alpha2 receptor inhibition of calcium channels in acutely-dissociated locus coeruleus neurones.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Baclofen; Barium; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Channels; Electric Stimulation; Electrophysiology; Enkephalins; GABA Agonists; GABA-B Receptor Agonists; In Vitro Techniques; Locus Coeruleus; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Receptors, Opioid | 1999 |
Apparent central nervous system depression in infants after the use of topical brimonidine.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Central Nervous System; Follow-Up Studies; Glaucoma; Humans; Infant; Infant, Newborn; Intraocular Pressure; Male; Nervous System Diseases; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines | 1999 |
Modulation of enteric cholinergic neurons by hetero- and autoreceptors: cooperation among inhibitory inputs.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cholinergic Fibers; Colon; Denervation; Guinea Pigs; Motor Neurons; Naltrexone; Norepinephrine; Peristalsis; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid; Sympathetic Nervous System | 1999 |
Gastrointestinal motor and myoelectric correlates of motion sickness.
Topics: Animals; Atropine Derivatives; Brimonidine Tartrate; Cats; Copper Sulfate; Digestive System; Female; Gastrointestinal Motility; Male; Motion Sickness; Myoelectric Complex, Migrating; Quinoxalines; Salivation; Vagotomy; Vomiting | 1999 |
Stimulation by transforming growth factor-alpha of DNA synthesis and proliferation of adult rat hepatocytes in primary cultures: modulation by alpha- and beta-adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Adrenergic Antagonists; Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Brimonidine Tartrate; Cell Division; Cells, Cultured; Dexamethasone; DNA; Dose-Response Relationship, Drug; Drug Interactions; ErbB Receptors; Isoquinolines; Liver; Male; Metaproterenol; Mitogen-Activated Protein Kinase Kinases; Phenylephrine; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinases; Quinoxalines; Rats; Rats, Wistar; Receptor Protein-Tyrosine Kinases; Ribosomal Protein S6 Kinases; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Time Factors; Transforming Growth Factor alpha; Type C Phospholipases | 1999 |
Differential effects of epinephrine and norepinephrine on cAMP response and g(i3)alpha protein expression in cultured sympathetic neurons.
Topics: Adrenergic Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Isoproterenol; Neurons; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Superior Cervical Ganglion | 1999 |
A comparative study of postsynaptic alpha2-adrenoceptors of the dog mesenteric and rat femoral veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cattle; Cricetinae; Dogs; Drug Interactions; Femoral Vein; Humans; In Vitro Techniques; Mesenteric Veins; Phenoxybenzamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Species Specificity | 1999 |
Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Brimonidine Tartrate; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Dendritic Cells; Drug Interactions; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Time Factors | 1999 |
Noradrenaline release from cultured mouse postganglionic sympathetic neurons: autoreceptor-mediated modulation.
Topics: Adenosine; Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Electric Stimulation; Ganglia, Sympathetic; Humans; Idazoxan; Kinetics; Mice; Mice, Inbred Strains; Neurons; Norepinephrine; Phenethylamines; Phentolamine; Purinergic P1 Receptor Agonists; Quinoxalines; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1999 |
Effects of some imidazolidine alpha2-adrenoceptor agonists in rat isolated atria.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Electric Stimulation; Female; Heart Atria; Heart Rate; Idazoxan; Imidazoles; In Vitro Techniques; Muscle Contraction; Norepinephrine; Pargyline; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Time Factors | 1999 |
Autoradiographical and behavioural effects of a chronic infusion of antisense to the alpha2D-adrenoceptor in the rat.
Topics: Animals; Autoradiography; Base Sequence; Behavior, Animal; Body Temperature; Brain; Brimonidine Tartrate; Idazoxan; Injections, Intraventricular; Male; Pupil; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Antisense | 1999 |
Noradrenaline and mixed alpha 2-adrenoceptor/imidazoline-receptor ligands: effects on sodium intake.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Appetite; Behavior, Animal; Brimonidine Tartrate; Dehydration; Drinking; Eating; Food Deprivation; Guanabenz; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Ligands; Male; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Satiation; Sodium, Dietary | 1999 |
Mechanisms of action of OPC-28326, a selective hindlimb vasodilator.
Topics: Adrenergic Antagonists; Anesthesia; Aniline Compounds; Animals; Blood Pressure; Brimonidine Tartrate; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Femoral Artery; Hemodynamics; Hindlimb; In Vitro Techniques; Male; Perfusion; Phenylephrine; Piperidines; Prazosin; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Vasodilator Agents; Yohimbine | 1999 |
Ca(2+)-independent phospholipase A2 is required for alpha2-adrenergic-induced preadipocyte spreading.
Topics: 3T3 Cells; Actins; Adipocytes; Adrenergic alpha-Agonists; Animals; Base Sequence; Brimonidine Tartrate; Calcium; Cell Adhesion; Cytoskeleton; DNA Primers; Humans; Lysophospholipids; Mice; Naphthalenes; Phospholipases A; Phospholipases A2; Pyrones; Quinoxalines; Receptors, Adrenergic, alpha-2; RNA, Messenger; Stem Cells | 1999 |
Effect of brimonidine on optic nerve blood flow in rabbits.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Ciliary Body; Corrosion Casting; Female; Male; Microcirculation; Microspheres; Optic Nerve; Quinoxalines; Rabbits; Regional Blood Flow; Vasoconstriction; Vasomotor System | 1999 |
alpha(2)-adrenoceptor and NPY receptor-mediated contractions of porcine isolated blood vessels: evidence for involvement of the vascular endothelium.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic Agonists; Animals; Brimonidine Tartrate; Colforsin; Endothelium, Vascular; Humans; Neuropeptide Y; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 1999 |
Demonstration of the reversibility of optic disc topography by scanning laser ophthalmoscopy.
Topics: Adrenergic alpha-Agonists; Aniridia; Brimonidine Tartrate; Child; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Lasers; Latanoprost; Male; Ophthalmoscopy; Optic Disk; Optic Nerve Diseases; Prostaglandins F, Synthetic; Quinoxalines; Trabeculectomy; Visual Acuity | 1999 |
Functional assessment of recombinant human alpha(2)-adrenoceptor subtypes with cytosensor microphysiometry.
Topics: Adrenergic alpha-Agonists; Amiloride; Animals; Binding, Competitive; Biosensing Techniques; Brimonidine Tartrate; CHO Cells; Cholera Toxin; Clonidine; Cricetinae; Dexmedetomidine; Egtazic Acid; Humans; Hydrogen-Ion Concentration; Norepinephrine; Pertussis Toxin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Signal Transduction; Virulence Factors, Bordetella | 1999 |
Effects of dietary L-arginine on the reactivity of canine coronary arteries.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Brimonidine Tartrate; Calcimycin; Coronary Vessels; Dietary Supplements; Dinoprost; Dogs; Endothelium, Vascular; Ionophores; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; omega-N-Methylarginine; Quinoxalines; Tetraethylammonium | 1999 |
alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels.
Topics: Adrenergic alpha-Agonists; Aspirin; Blood Platelets; Brimonidine Tartrate; Calcium; Calcium Chloride; Carbazoles; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Epinephrine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Models, Biological; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Prostaglandins E; Pyrroles; Quinoxalines; Receptors, Adrenergic, alpha-2; Stimulation, Chemical; Thapsigargin; Thimerosal; Thrombin; Time Factors | 2000 |
Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cerebral Cortex; Crosses, Genetic; Gene Deletion; Heart Atria; Hemodynamics; Mice; Myocardium; Neural Inhibition; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Synaptic Transmission | 1999 |
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clathrin; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; GTP-Binding Proteins; Isoproterenol; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cell Surface; Transfection; Tyrphostins | 2000 |
Platelet alpha2-adrenoceptor alterations in patients with essential hypertension are normalized after treatment with doxazosin but not propranolol.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Blood Platelets; Brimonidine Tartrate; Case-Control Studies; Cell Membrane; Doxazosin; Female; Humans; Hypertension; In Vitro Techniques; Kinetics; Male; Middle Aged; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha-2 | 2000 |
Severe systemic toxicity caused by brimonidine drops in an infant with presumed juvenile xanthogranuloma.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Female; Humans; Infant; Ophthalmic Solutions; Quinoxalines; Xanthogranuloma, Juvenile | 1999 |
Initial medical management of open-angle glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Hypertension; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Quinoxalines | 2000 |
The mechanisms of alpha(2)-adrenoceptor agonist-induced contraction in longitudinal muscle of the porcine uterus.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Clonidine; Colforsin; Cyclic AMP; Female; Fluorescent Dyes; Fura-2; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myometrium; Pertussis Toxin; Quinoxalines; Swine; Uterus; Verapamil; Virulence Factors, Bordetella | 2000 |
Hypercholesterolemia increases coronary endothelial dysfunction, lipid content, and accelerated atherosclerosis after heart transplantation.
Topics: Adrenergic alpha-Agonists; Animals; Arteriosclerosis; Biological Transport; Brimonidine Tartrate; Calcimycin; Calcium; Cholesterol, HDL; Cholesterol, LDL; Coronary Vessels; Diet, Atherogenic; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; Erythrocyte Count; Female; Free Radical Scavengers; Heart Transplantation; Hematocrit; Hemoglobins; Hypercholesterolemia; Hyperplasia; Ionophores; Male; Myocardium; Postoperative Period; Potassium Chloride; Quinoxalines; Serotonin; Swine; Transplantation, Homologous; Tunica Intima; Vasodilation | 2000 |
Oxytocin/alpha(2)-Adrenoceptor interactions in feeding responses.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain; Brimonidine Tartrate; Clonidine; Eating; Injections, Intraventricular; Male; Oxytocin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tissue Distribution | 2000 |
Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Humans; Idazoxan; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Serine; Transfection; Tritium; Yohimbine | 2000 |
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Brimonidine Tartrate; Cell Line; Cricetinae; Dexmedetomidine; Dose-Response Relationship, Drug; Doxazosin; Gene Expression; Humans; Hydrogen-Ion Concentration; Imidazoles; Norepinephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Tetrahydronaphthalenes; Yohimbine | 2000 |
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aniline Compounds; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Calcium; Cell Line; Cricetinae; Dexmedetomidine; Dose-Response Relationship, Drug; Doxazosin; Estrenes; Fluorescence; Gene Expression; Humans; Imidazoles; Norepinephrine; Prazosin; Pyrrolidinones; Quinoxalines; Radioligand Assay; Receptor Cross-Talk; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Signal Transduction; Tetrahydronaphthalenes; Thapsigargin; Xanthenes; Yohimbine | 2000 |
Silent alpha(2C)-adrenergic receptors enable cold-induced vasoconstriction in cutaneous arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; COS Cells; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Microcirculation; Muscle, Smooth, Vascular; Organ Culture Techniques; Phenylephrine; Piperazines; Quinolizines; Quinoxalines; Raynaud Disease; Receptors, Adrenergic, alpha-2; Scleroderma, Systemic; Skin; Tail; Vasoconstriction | 2000 |
Regulation of NHE3 activity by G protein subunits in renal brush-border membranes.
Topics: Adrenergic alpha-Agonists; Amiloride; Animals; Benzazepines; Brimonidine Tartrate; Cell Line, Transformed; Dopamine Agonists; Dose-Response Relationship, Drug; Enzyme Activation; Fenoldopam; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Kidney Tubules, Proximal; Male; Microvilli; Neuroprotective Agents; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, Dopamine D1; Second Messenger Systems; Sodium Radioisotopes; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Virulence Factors, Bordetella | 2000 |
The regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Kinetics; Mutation; Proto-Oncogene Proteins; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; RGS Proteins; Swine | 2000 |
Comparison of the efficacy and safety of latanoprost 0.005% compared to brimonidine 0.2% or dorzolamide 2% when added to a topical beta-adrenergic blocker in patients with primary open-angle glaucoma or ocular hypertension.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Safety; Sulfonamides; Thiophenes; Tonometry, Ocular | 2000 |
Interactions between the alpha(2)-adrenergic and the prostaglandin response in the regulation of macrophage-derived tumor necrosis factor.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Female; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Mice, Inbred CBA; Quinoxalines; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tumor Necrosis Factor-alpha | 2000 |
Alpha(2)-adrenoceptor-stimulated GTP gamma S binding in rat brain: an autoradiographic study.
Topics: Animals; Autoradiography; Brain; Brimonidine Tartrate; Dose-Response Relationship, Drug; Epinephrine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Serotonin | 2000 |
Incidence of brimonidine allergy in patients previously allergic to apraclonidine.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Clonidine; Conjunctivitis; Cross Reactions; Dermatitis, Allergic Contact; Drug Hypersensitivity; Female; Glaucoma; Humans; Hyperemia; Incidence; Male; Middle Aged; Quinoxalines; Retrospective Studies; Risk Factors | 2000 |
Agonist efficacy at the alpha2A-adrenoceptor:G alpha15 fusion protein: an analysis based on Ca2+ responses.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; CHO Cells; Cricetinae; Epinephrine; Fluorescent Dyes; GTP-Binding Proteins; Humans; Idazoxan; Ligands; Mice; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2000 |
Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: II. In vitro studies in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Autoreceptors; Brimonidine Tartrate; Carrier Proteins; Cricetinae; Cyclohexanols; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1B; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Plasma Membrane Transport Proteins; Serotonin Receptor Agonists; Symporters; Time Factors; Tritium; Venlafaxine Hydrochloride | 2000 |
mu-opioid receptor and alpha2-adrenoceptor agonist stimulation of [35S]GTPgammaS binding to G-proteins in postmortem brains of opioid addicts.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Autopsy; Brain; Brimonidine Tartrate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Male; Opioid-Related Disorders; Postmortem Changes; Quinoxalines; Receptors, Opioid, mu; Reference Values; Sulfur Radioisotopes | 2000 |
Effect of brimonidine on rabbit trabecular meshwork hyaluronidase activity.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cyclic AMP; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Male; Quinoxalines; Rabbits; Radioimmunoassay; Trabecular Meshwork; Yohimbine | 2000 |
The teardrop sign: a rare dermatological reaction to brimonidine.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Drug Eruptions; Facial Dermatoses; Humans; Male; Quinoxalines | 2000 |
Chronic morphine treatment and withdrawal increase extracellular levels of norepinephrine in the rat bed nucleus of the stria terminalis.
Topics: Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Extracellular Space; Glutamic Acid; In Vitro Techniques; Male; Microdialysis; Morphine; Morphine Dependence; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance Withdrawal Syndrome | 2000 |
Agonist-directed trafficking of porcine alpha(2A)-adrenergic receptor signaling in Chinese hamster ovary cells: l-isoproterenol selectively activates G(s).
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Binding Sites; Brimonidine Tartrate; CHO Cells; Cricetinae; Drug Interactions; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Isoproterenol; Kinetics; Oxymetazoline; Pindolol; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Serotonin Antagonists; Signal Transduction; Swine; Yohimbine | 2000 |
A case of suspected alphagan-induced psychosis.
Topics: Acute Disease; Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Delirium; Glaucoma, Open-Angle; Hallucinations; Humans; Intraocular Pressure; Male; Psychoses, Substance-Induced; Quinoxalines; Visual Acuity | 2000 |
Multiple receptor activation elicits synergistic IP formation in nonpigmented ciliary body epithelial cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Carbachol; Cells, Cultured; Ciliary Body; Epithelial Cells; Inositol Phosphates; Muscarinic Agonists; Muscarinic Antagonists; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Signal Transduction | 2000 |
Short-term treatment with transdermal nicotine affects the function of canine saphenous veins.
Topics: Administration, Cutaneous; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcimycin; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Isometric Contraction; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nicotine; Nitric Oxide; omega-N-Methylarginine; Potassium Chloride; Quinoxalines; Saphenous Vein | 2000 |
Increased alpha2-adrenergic constriction of isolated arterioles in diffuse scleroderma.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Arterioles; Brimonidine Tartrate; Female; Humans; Male; Middle Aged; Phenylephrine; Quinoxalines; Scleroderma, Systemic; Vasoconstriction; Vasodilator Agents | 2000 |
Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Heterozygote; Homeostasis; Humans; Idazoxan; Immunohistochemistry; Insulin; Islets of Langerhans; Mice; Mice, Transgenic; Promoter Regions, Genetic; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
Capillary electrophoretic analysis of brimonidine in aqueous humor of the eye and blood sera and relation of its levels with intraocular pressure.
Topics: Adrenergic alpha-Agonists; Aged; Aqueous Humor; Brimonidine Tartrate; Calibration; Electrophoresis, Capillary; Female; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Quinoxalines | 2000 |
Reduced alpha(2)-adrenergic sensitivity of subcutaneous abdominal adipocytes as a modulator of fasting and postprandial triglyceride levels in men.
Topics: Abdomen; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Glucose; Brimonidine Tartrate; Epinephrine; Fasting; Glycerol; Humans; In Vitro Techniques; Insulin; Isoproterenol; Lipolysis; Lipoprotein Lipase; Lipoproteins; Male; Postprandial Period; Quinoxalines; Receptors, Adrenergic, alpha-2; Skin | 2000 |
Food deprivation increases alpha(2)-adrenoceptor-mediated modulation of jejunal epithelial transport in young and adult rats.
Topics: Animals; Biological Transport; Brimonidine Tartrate; Carrier Proteins; Electric Conductivity; Epithelium; Food Deprivation; Furosemide; Jejunum; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Tritium; Yohimbine | 2000 |
Anterior uveitis as a side effect of topical brimonidine.
Topics: Acute Disease; Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Anterior Eye Segment; Brimonidine Tartrate; Female; Glaucoma; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Quinoxalines; Recurrence; Uveitis, Anterior; Visual Acuity | 2000 |
Alpha-2 adrenoceptors are present in rat aorta smooth muscle cells, and their action is mediated by ATP-sensitive K(+) channels.
Topics: Adenosine Triphosphate; Animals; Aorta; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 2000 |
Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides.
Topics: Adrenergic alpha-Agonists; Allosteric Regulation; Amiloride; Animals; Brimonidine Tartrate; CHO Cells; Cricetinae; Diuretics; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Quinoxalines; Receptors, Adrenergic, alpha-2; Sulfur Radioisotopes; Transfection | 2000 |
Presynaptic modulation of sympathetic neurotransmission in rat left ventricle slices: effect of pressure overload.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic Fibers; Adrenergic Uptake Inhibitors; Albuterol; Animals; Brimonidine Tartrate; Cerebral Ventricles; Desipramine; Male; Norepinephrine; Organ Culture Techniques; Presynaptic Terminals; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; Sympathomimetics; Synaptic Transmission; Tritium; Ventricular Pressure | 2000 |
Effect of norepinephrine receptors on trigeminal rhythm generation in newborn rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Bicuculline; Brimonidine Tartrate; Idazoxan; Mastication; Motor Neurons; N-Methylaspartate; Neural Pathways; Norepinephrine; Organ Culture Techniques; Phenylephrine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Trigeminal Nuclei | 2000 |
Partial to complete antagonism by putative antagonists at the wild-type alpha(2C)-adrenoceptor based on kinetic analyses of agonist:antagonist interactions.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Calcium; CHO Cells; Clonidine; Cricetinae; DNA, Recombinant; Dose-Response Relationship, Drug; Drug Interactions; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Heterotrimeric GTP-Binding Proteins; Idazoxan; Kinetics; Medetomidine; Mice; Oxymetazoline; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Transfection | 2000 |
RGC death in mice after optic nerve crush injury: oxidative stress and neuroprotection.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Death; Cell Survival; Mice; Mice, Transgenic; Nerve Crush; Neuroprotective Agents; Optic Nerve; Optic Nerve Injuries; Oxidative Stress; Quinoxalines; Receptors, Adrenergic, alpha-2; Retinal Ganglion Cells; Superoxide Dismutase | 2000 |
Increased noradrenergic activity in prefrontal cortex slices of an animal model for attention-deficit hyperactivity disorder--the spontaneously hypertensive rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Attention Deficit Disorder with Hyperactivity; Brimonidine Tartrate; Disease Models, Animal; Dopamine; Down-Regulation; Hypertension; Idazoxan; In Vitro Techniques; Male; Models, Neurological; Norepinephrine; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Long-Evans; Receptors, Adrenergic, alpha-2 | 2000 |
Influence of nitric oxide donors and of the alpha(2)-agonist UK-14,304 on acetylcholine release in the pig gastric fundus.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Gastric Fundus; In Vitro Techniques; Nitric Oxide Donors; Nitric Oxide Synthase; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine | 2001 |
Increased alpha(1)- and alpha(2)-adrenoceptor-mediated contractile responses of human skeletal muscle resistance arteries in chronic limb ischemia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aged; Antihypertensive Agents; Arteries; Brimonidine Tartrate; Chronic Disease; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Ischemia; Leg; Male; Middle Aged; Muscle, Skeletal; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Vasoconstrictor Agents | 2001 |
alpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Brimonidine Tartrate; Chromatography, Liquid; Electroretinography; Extracellular Space; Glutamic Acid; Ischemia; Male; Mass Spectrometry; Quinoxalines; Rats; Rats, Inbred BN; Retina; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body; Yohimbine | 2001 |
Comparison of the ocular hypotensive effect of brimonidine, dorzolamide, latanoprost, or artificial tears added to timolol in glaucomatous monkey eyes.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Drug Synergism; Drug Therapy, Combination; Female; Glaucoma; Intraocular Pressure; Latanoprost; Macaca fascicularis; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Random Allocation; Sulfonamides; Thiophenes; Timolol | 2000 |
Systemic oxytocin treatment modulates alpha 2-adrenoceptors in telencephalic and diencephalic regions of the rat.
Topics: Adrenergic alpha-Agonists; Amygdala; Animals; Autoradiography; Brimonidine Tartrate; Diencephalon; Hypothalamus; Male; Oxytocin; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Telencephalon; Tritium | 2000 |
Alpha2-adrenoceptor-mediated inhibition of cultured sympathetic neurons: changes in alpha2A/D-adrenoceptor-deficient mice.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Female; Ganglia, Sympathetic; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Neurons; Norepinephrine; Pertussis Toxin; Phentolamine; Quinoxalines; Receptors, Adrenergic, alpha-2; Tritium; Virulence Factors, Bordetella; Yohimbine | 2001 |
Postjunctional alpha(2C)-adrenoceptor contractility in human saphenous vein.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Animals; Azepines; Brimonidine Tartrate; CHO Cells; Cricetinae; Dioxanes; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Saphenous Vein; Vasoconstriction; Yohimbine | 2001 |
Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning.
Topics: Adenosine; Analysis of Variance; Animals; Brimonidine Tartrate; Electric Stimulation; Enzyme Inhibitors; Male; Myocardial Stunning; Myocardium; Norepinephrine; Perfusion; Phenethylamines; Phenylisopropyladenosine; Purinergic Antagonists; Purinergic P1 Receptor Antagonists; Quinoxalines; Rats; Rats, Wistar; Receptors, Purinergic P1; Receptors, Purinergic P2; Sympathetic Nervous System; Theophylline; Time Factors; Xanthines | 2001 |
Ophthalmic drops causing coma in an infant.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Coma; Eye Abnormalities; Humans; Infant, Newborn; Male; Ophthalmic Solutions; Practice Guidelines as Topic; Quinoxalines; Syndrome | 2001 |
Effects of verapamil and elgodipine on isoprenaline-induced metabolic responses in rabbits.
Topics: Adipose Tissue; Animals; Blood Glucose; Brimonidine Tartrate; Calcium Channel Blockers; Colforsin; Consciousness; Dihydropyridines; Dose-Response Relationship, Drug; Epinephrine; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Isoproterenol; Male; Metabolism; Potassium; Quinoxalines; Rabbits; Verapamil | 2001 |
Evidence for a non-adrenoceptor, imidazoline-mediated contractile response to oxymetazoline in the porcine isolated rectal artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Animals; Arteries; Benzofurans; Brimonidine Tartrate; Colforsin; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Norepinephrine; Oxymetazoline; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Receptors, Adrenergic; Rectum; Swine; Vasoconstriction | 2001 |
Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Gene Expression Regulation; GTP-Binding Proteins; Idazoxan; Male; Membranes; Norepinephrine; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reserpine; RNA, Messenger; Tritium | 2001 |
A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; GTP-Binding Proteins; Guanosine Triphosphate; Idazoxan; Microtomy; Nucleotides; Protein Binding; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium | 2001 |
Effects of dietary L-arginine on structure and function of flow-restricted vein grafts.
Topics: Adrenergic alpha-Agonists; Amino Acids; Animals; Arginine; Blood Flow Velocity; Brimonidine Tartrate; Calcimycin; Constriction, Pathologic; Dietary Supplements; Dogs; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Quinoxalines; Saphenous Vein; Vascular Patency | 2001 |
Effect of brimonidine tartrate ophthalmic solution 0.2% on pupil size in normal eyes under different luminance conditions.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Female; Humans; Lighting; Male; Middle Aged; Miosis; Ophthalmic Solutions; Pupil; Quinoxalines; Reflex, Pupillary; Vision Disorders | 2001 |
[Neuroprotection. Bases and possibilities of a future clinical use].
Topics: Adrenergic alpha-Agonists; Animals; Apoptosis; Brimonidine Tartrate; Clinical Trials as Topic; Disease Models, Animal; Dopamine Agents; Eye Diseases; Forecasting; Glaucoma; Humans; Memantine; Neuroprotective Agents; Optic Neuritis; Quinoxalines; Retinal Diseases; Visual Fields | 2001 |
[Modulatory action of alpha 2-adrenoceptor on calcitonin gene-related peptide release from rat mesenteric arterial bed].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcitonin Gene-Related Peptide; Endotoxins; In Vitro Techniques; Male; Mesenteric Arteries; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine | 1998 |
Retinal ganglion cell death induced by retinal ischemia. neuroprotective effects of two alpha-2 agonists.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Count; Cell Death; Cell Survival; Humans; Neuroprotective Agents; Ophthalmic Solutions; Quinoxalines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells | 2001 |
Role of alpha-2 adrenergic receptors in neuroprotection and glaucoma.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Count; Cell Survival; Immunoenzyme Techniques; Intraocular Pressure; Neuroprotective Agents; Ocular Hypertension; Optic Nerve Injuries; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Retina; Retinal Ganglion Cells; Signal Transduction | 2001 |
Washout periods for brimonidine 0.2% and latanoprost 0.005%.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Single-Blind Method; Time Factors | 2001 |
Quantitation of mitomycin C in human ocular tissues by high-performance liquid chromatography-photo-diode array detection.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Chromatography, High Pressure Liquid; Glaucoma; Humans; Mitomycin; Molecular Structure; Premedication; Quinoxalines; Sclera; Timolol; Trabeculectomy | 2001 |
Alpha-adrenoceptor agonists produce Ca2+ oscillations in isolated rat aorta: role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Signaling; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Verapamil | 2000 |
Brimonidine and inhibition of nitrite production in isolated porcine ciliary processes.
Topics: Adrenergic alpha-Agonists; Animals; Aqueous Humor; Brimonidine Tartrate; Ciliary Body; Colforsin; Intraocular Pressure; Nitric Oxide; Nitrites; Quinoxalines; Swine | 2001 |
Disturbance of the prejunctional modulation of cholinergic neurotransmission during chronic granulomatous inflammation of the mouse ileum.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Brimonidine Tartrate; Carbachol; Cholinergic Agents; Cholinergic Agonists; Cholinergic Antagonists; Chronic Disease; Dimethylphenylpiperazinium Iodide; Dose-Response Relationship, Drug; Electric Stimulation; Granuloma; Hexamethonium; Histamine; Histamine Agonists; Histamine Antagonists; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Neuromuscular Junction; Peroxidase; Quinoxalines; Receptors, Histamine; Schistosoma mansoni; Schistosomiasis mansoni; Synaptic Transmission; Tetrodotoxin | 2001 |
The alpha(1A)-adrenoceptor subtype mediates contraction in rat femoral resistance arteries.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Femoral Artery; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Naphthyridines; Norepinephrine; Phenylephrine; Piperazines; Prazosin; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tetrahydronaphthalenes; Vascular Resistance; Vasoconstriction | 2001 |
Differential effects of alpha-adrenoceptor agonists on human retinal microvessel diameter.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cheek; Clonidine; Cricetinae; Humans; Mesocricetus; Muscle, Smooth, Vascular; Quinoxalines; Retina; Retinal Vessels; Vasoconstriction | 2001 |
Role of the extracellular signal-regulated kinase (Erk) signal transduction cascade in alpha(2) adrenoceptor-mediated vasoconstriction in porcine palmar lateral vein.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Butadienes; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Forelimb; Genistein; Isoflavones; Mitogen-Activated Protein Kinases; Nifedipine; Nitriles; Potassium Chloride; Quinoxalines; Receptors, Adrenergic, alpha-2; Signal Transduction; Swine; Vasoconstriction; Vasodilator Agents; Veins; Verapamil | 2001 |
Role of alpha(2)-adrenoceptors in the sympathetic inhibition of motility reflexes of guinea-pig ileum.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Electric Stimulation; Female; Ganglionic Blockers; Gastrointestinal Motility; Guinea Pigs; Hexamethonium; Ileum; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth; Physical Stimulation; Quinoxalines; Receptors, Adrenergic, alpha-2; Reflex; Sympathetic Nervous System | 2001 |
The effect of adrenergic compounds on neurogenic dural vasodilatation.
Topics: Adrenergic Agents; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Blood Vessels; Brimonidine Tartrate; Dose-Response Relationship, Drug; Dura Mater; Electric Stimulation; Injections, Intravenous; Male; Phenylephrine; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilation; Yohimbine | 2001 |
Systemic beta-blocker therapy and brimonidine and timolol.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Brimonidine Tartrate; Clinical Trials as Topic; Glaucoma, Open-Angle; Hemodynamics; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Safety; Timolol | 2001 |
The adverse effect of perioperative brimonidine tartrate 0.2% on flap adherence and enhancement rates in laser in situ keratomileusis patients.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Brimonidine Tartrate; Corneal Diseases; Corneal Stroma; Female; Humans; Keratomileusis, Laser In Situ; Male; Middle Aged; Ophthalmic Solutions; Preoperative Care; Quinoxalines; Refractive Surgical Procedures; Retrospective Studies; Surgical Flaps; Tissue Adhesions; Visual Acuity | 2001 |
Potent alpha(2A)-adrenoceptor-mediated vasoconstriction by brimonidine in porcine ciliary arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Ciliary Arteries; Clonidine; Dose-Response Relationship, Drug; Isometric Contraction; Muscle, Smooth, Vascular; Oxymetazoline; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine; Vasoconstriction | 2001 |
Neuroprotective effects of alpha(2)-selective adrenergic agonists against ischemia-induced retinal ganglion cell death.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Count; Cell Survival; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Diseases; Retinal Ganglion Cells | 2001 |
Effects of central imidazolinergic and alpha2-adrenergic activation on water intake.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Drinking; Guanidines; Imidazoles; Injections, Intraventricular; Ligands; Male; Nordefrin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Vasoconstrictor Agents; Water Deprivation | 2001 |
Topically applied clonidine protects the rat retina from ischaemia/reperfusion by stimulating alpha(2)-adrenoceptors and not by an action on imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bridged Bicyclo Compounds; Brimonidine Tartrate; Calbindin 2; Cell Death; Choline O-Acetyltransferase; Clonidine; Electroretinography; Heptanes; Imidazoline Receptors; Immunohistochemistry; Membrane Potentials; Nerve Degeneration; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Reperfusion Injury; Retina; Retinal Ganglion Cells; S100 Calcium Binding Protein G; Yohimbine | 2001 |
Neuroprotective effect of alpha(2) agonist (brimonidine) on adult rat retinal ganglion cells after increased intraocular pressure.
Topics: Adrenergic alpha-Antagonists; Age Factors; Animals; Brimonidine Tartrate; Cell Count; Cell Survival; Disease Models, Animal; Female; Glaucoma; Intraocular Pressure; Nerve Degeneration; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Retinal Ganglion Cells; Time Factors | 2001 |
Enhanced interaction between renovascular alpha(2)-adrenoceptors and angiotensin II receptors in genetic hypertension.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Animals; Antihypertensive Agents; Arginine Vasopressin; Blood Pressure; Brimonidine Tartrate; Captopril; Hypertension; Male; Methoxamine; Nephrectomy; Protein Binding; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Angiotensin; Renal Artery; Renal Circulation; Species Specificity; Vascular Resistance; Vasoconstrictor Agents | 2001 |
Acute and chronic effects of brimonidine 0.2% on intraocular pressure and pulsatile ocular blood flow in patients with primary open-angle glaucoma: an open-label, uncontrolled, prospective study.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Drug Administration Schedule; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Pulsatile Flow; Quinoxalines; Time Factors | 2001 |
alpha(2)-adrenoceptor antagonist properties of OPC-28326, a novel selective peripheral vasodilator.
Topics: Adrenergic alpha-Antagonists; Aniline Compounds; Animals; Azepines; Binding, Competitive; Blood Pressure; Brimonidine Tartrate; Decerebrate State; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Muscle Contraction; Mydriasis; Piperidines; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Vas Deferens; Vasodilator Agents; Yohimbine | 2001 |
Ca2+ influx mediates enhanced alpha2-adrenergic contraction in aortas from rats treated with NOS inhibitor.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Enzyme Inhibitors; Hypertension; Male; Muscle, Smooth, Vascular; Nifedipine; Nitric Oxide Synthase; Nitroarginine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Vasoconstriction | 2001 |
[Experience with topical brimonidine in the treatment of glaucomas].
Topics: Antihypertensive Agents; Brimonidine Tartrate; Glaucoma; Humans; Quinoxalines | 2001 |
[Brimonidine absorption and release from 1. Day acuvue disposable contact lenses].
Topics: Absorption; Adrenergic alpha-Agonists; Brimonidine Tartrate; Contact Lenses, Hydrophilic; Ophthalmic Solutions; Pharmaceutical Vehicles; Quinoxalines | 2001 |
Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Cell Survival; Chronic Disease; Cytoprotection; Glial Fibrillary Acidic Protein; Intraocular Pressure; Laser Coagulation; Male; Neuroprotective Agents; Ocular Hypertension; Quinoxalines; Rats; Rats, Wistar; Retina; Retinal Ganglion Cells; Time Factors; Timolol | 2001 |
[Prospects for neuroprotective glaucoma therapy].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Apoptosis; Betaxolol; Brain-Derived Neurotrophic Factor; Brimonidine Tartrate; Calcium Channel Blockers; Disease Models, Animal; Dopamine Agents; Glaucoma; Glaucoma, Open-Angle; Haplorhini; Humans; Memantine; Neuroprotective Agents; Nimodipine; Nitric Oxide Synthase; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2001 |
Noradrenaline stimulates 5-hydroxytryptamine release from mouse ileal tissues via alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Ileum; In Vitro Techniques; Male; Methoxamine; Mice; Mice, Inbred ICR; Norepinephrine; Pertussis Toxin; Phenylephrine; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha-2; Serotonin; Virulence Factors, Bordetella; Yohimbine | 2001 |
The impact of new drugs on management of glaucoma in Scotland: observational study.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Utilization; Glaucoma; Humans; Practice Patterns, Physicians'; Prostaglandins, Synthetic; Quinoxalines; Scotland; Trabeculectomy | 2001 |
Tumor necrosis factor expressed by primary hippocampal neurons and SH-SY5Y cells is regulated by alpha(2)-adrenergic receptor activation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Carcinogens; Cell Differentiation; Cell Extracts; Cells, Cultured; Dose-Response Relationship, Drug; Hippocampus; Immunohistochemistry; Male; Membrane Potentials; Neurons; Norepinephrine; Potassium; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; RNA, Messenger; Sympathomimetics; Synaptic Transmission; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Tyramine | 2002 |
Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Atropine; Benzofurans; Brimonidine Tartrate; Dioxanes; Enzyme Inhibitors; Evoked Potentials; Female; Gastric Fundus; Gastrointestinal Agents; Humans; Male; Middle Aged; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Piperidines; Quinoxalines; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Presynaptic; Receptors, Serotonin; Receptors, Serotonin, 5-HT4; Receptors, Vasoactive Intestinal Peptide; Serotonin Antagonists; Stomach; Synaptic Transmission; Vasoactive Intestinal Peptide; Yohimbine | 2002 |
Minimally invasive spectroscopic system for intraocular drug detection.
Topics: Adrenergic alpha-Agonists; Anterior Chamber; Anti-Bacterial Agents; Aqueous Humor; Brimonidine Tartrate; Contact Lenses; Contact Lenses, Hydrophilic; Contrast Media; Equipment Design; Eye; Fluorescein; Humans; Quinoxalines; Spectrum Analysis; Tetracycline | 2002 |
Modification of serotonin neuron properties in mice lacking 5-HT1A receptors.
Topics: Animals; Autoreceptors; Brimonidine Tartrate; Hippocampus; In Vitro Techniques; Male; Mice; Neurons; Norepinephrine; Pyridines; Pyrroles; Quinoxalines; Raphe Nuclei; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tritium | 2002 |
Clinical effects of brimonidine ophthalmic drops ingestion in 52 dogs.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Dogs; Humans; Ophthalmic Solutions; Poisoning; Quinoxalines | 2002 |
Substance P, insulinlike growth factor 1, and surface healing.
Topics: Aged; Anti-Bacterial Agents; Antihypertensive Agents; Brimonidine Tartrate; Corneal Diseases; Drug Therapy, Combination; Epithelium, Corneal; Female; Humans; Insulin-Like Growth Factor I; Keratoplasty, Penetrating; Ophthalmic Solutions; Polymyxin B; Quinoxalines; Substance P; Wound Healing | 2002 |
Lysophosphatidylcholine potentiates vascular contractile responses in rat aorta via activation of tyrosine kinase.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Genistein; Lysophosphatidylcholines; Male; Muscle Contraction; Phosphorylation; Potassium; Protein-Tyrosine Kinases; Quinoxalines; Rats; Rats, Wistar; Vasoconstrictor Agents | 2002 |
Analysis of the effects of graded levels of hypoxia on noradrenaline-evoked contraction in the rat iliac artery in vitro.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Endothelium, Vascular; Glyburide; Hypoglycemic Agents; Hypoxia; Iliac Artery; In Vitro Techniques; Male; Nicardipine; Norepinephrine; Oxygen; Potassium; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasoconstrictor Agents | 2002 |
Allergic reactions to brimonidine in patients treated for glaucoma.
Topics: Adrenergic alpha-Agonists; Aged; Antihypertensive Agents; Brimonidine Tartrate; Conjunctivitis, Allergic; Dermatitis, Allergic Contact; Drug Hypersensitivity; Female; Glaucoma; Humans; Levobunolol; Male; Quinoxalines; Retrospective Studies; Seasons | 2002 |
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Bacterial Proteins; Brimonidine Tartrate; Butadienes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Pertussis Toxin; Phosphorylation; Protein Binding; Proteins; Quinacrine; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Swine; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2002 |
Distribution of brimonidine into anterior and posterior tissues of monkey, rabbit, and rat eyes.
Topics: Administration, Topical; Animals; Brimonidine Tartrate; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Eye; Injections, Intraperitoneal; Iris; Macaca fascicularis; Metabolic Clearance Rate; Quinoxalines; Rabbits; Rats; Tissue Distribution; Vitreous Body | 2002 |
Effects of acute and subchronic administration of dexefaroxan, an alpha(2)-adrenoceptor antagonist, on memory performance in young adult and aged rodents.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Anti-Anxiety Agents; Avoidance Learning; Basal Nucleus of Meynert; Benzopyrans; Brimonidine Tartrate; Cholinesterase Inhibitors; Cognition; Diazepam; Excitatory Amino Acid Agonists; Ibotenic Acid; Imidazoles; Male; Maze Learning; Memory; Mice; Muscarinic Antagonists; Quinoxalines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2002 |
Neuroprotective effects of brimonidine against transient ischemia-induced retinal ganglion cell death: a dose response in vivo study.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Death; Dose-Response Relationship, Drug; Ischemia; Microscopy, Fluorescence; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Diseases; Retinal Ganglion Cells; Time Factors | 2002 |
ATP release in human kidney cortex and its mitogenic effects in visceral glomerular epithelial cells.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Brimonidine Tartrate; Cell Division; Cells, Cultured; Electric Stimulation; Epithelial Cells; Gene Expression; Humans; Kidney Cortex; Kidney Failure, Chronic; Kidney Glomerulus; MAP Kinase Signaling System; Mitogens; Norepinephrine; Organ Culture Techniques; Quinoxalines; Receptors, Purinergic P2; Reverse Transcriptase Polymerase Chain Reaction; Sympathetic Nervous System; Thymidine; Tritium | 2002 |
The effects of new topical treatments on management of glaucoma in Scotland: an examination of ophthalmological health care.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Costs; Drug Prescriptions; Glaucoma; Humans; Latanoprost; Middle Aged; Miotics; Prostaglandins F, Synthetic; Prostaglandins, Synthetic; Quinoxalines; Retrospective Studies; Scotland; Sulfonamides; Sympathomimetics; Thiophenes; Trabeculectomy | 2002 |
Brimonidine 0.2% to prevent post laser IOP elevation.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Iris; Laser Therapy; Ocular Hypertension; Postoperative Complications; Quinoxalines; Trabeculectomy | 2002 |
Delayed hypersensitivity to brimonidine tartrate 0.2% associated with high intraocular pressure.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Drug Hypersensitivity; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines | 2002 |
The efficacy of brimonidine in preventing intraocular pressure elevation in the provocative test for primary angle-closure glaucoma.
Topics: Adult; Aged; Brimonidine Tartrate; Darkness; Female; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Male; Middle Aged; Posture; Prone Position; Quinoxalines | 2002 |
Failure of naloxone to reverse brimonidine-induced coma in an infant.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Coma; Dose-Response Relationship, Drug; Humans; Infant; Naloxone; Narcotic Antagonists; Quinoxalines; Treatment Failure | 2002 |
Pre- and postjunctional alpha(2)-adrenergic receptors in fetal and adult ovine cerebral arteries.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Animals; Binding, Competitive; Brimonidine Tartrate; Cerebral Arteries; Clonidine; Dose-Response Relationship, Drug; Female; Fetus; Idazoxan; Middle Cerebral Artery; Norepinephrine; Phenylephrine; Pregnancy; Quinoxalines; Receptors, Adrenergic, alpha-2; Sheep; Tetrodotoxin; Vasoconstriction; Vasoconstrictor Agents; Yohimbine | 2002 |
Stimulation of alpha2-adrenergic receptor inhibits cholangiocarcinoma growth through modulation of Raf-1 and B-Raf activities.
Topics: Adrenergic alpha-Agonists; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Blotting, Western; Brimonidine Tartrate; Cell Division; Cholangiocarcinoma; Cyclic AMP; Humans; Inositol 1,4,5-Trisphosphate; MAP Kinase Signaling System; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-raf; Quinoxalines; ras Proteins; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured | 2002 |
Additive intraocular pressure lowering effect of various medications with latanoprost.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Synergism; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Sulfonamides; Thiophenes | 2002 |
Scleritis as the initial clinical manifestation of graft-versus-host disease after allogenic bone marrow transplantation.
Topics: Acetazolamide; Bone Marrow Transplantation; Brimonidine Tartrate; Choroid Diseases; Drug Therapy, Combination; Graft vs Host Disease; Humans; Lymphoma, T-Cell; Male; Methylprednisolone; Middle Aged; Pain; Quinoxalines; Scleritis; Transplantation, Homologous | 2002 |
Up-regulation of brain-derived neurotrophic factor expression by brimonidine in rat retinal ganglion cells.
Topics: Adrenergic alpha-Agonists; Animals; Blotting, Northern; Brain-Derived Neurotrophic Factor; Brimonidine Tartrate; In Situ Hybridization; Injections; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; RNA, Messenger; Up-Regulation; Vitreous Body | 2002 |
Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors.
Topics: Adrenergic alpha-Agonists; Amino Acid Motifs; Amino Acid Sequence; Arginine; Binding, Competitive; Brimonidine Tartrate; Catalysis; Cell Line; Circular Dichroism; Cyclic AMP; Cytoplasm; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptide Biosynthesis; Peptides; Plasmids; Protein Structure, Secondary; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Transfection | 2002 |
Effect of hyaluronic acid on intraocular pressure in rats.
Topics: Animals; Anterior Chamber; Antihypertensive Agents; Brimonidine Tartrate; Disease Models, Animal; Hyaluronic Acid; Injections; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Timolol; Tonometry, Ocular | 2002 |
Role of mu-opioid receptors in insulin release in the presence of inhibitory and excitatory secretagogues.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Clonidine; Drug Interactions; Female; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Naloxone; Quinoxalines; Receptors, Opioid, mu; Somatostatin | 2002 |
Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Brimonidine Tartrate; Calcium; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Fura-2; Glutamic Acid; Metoprolol; N-Methylaspartate; Neuroglia; Neuroprotective Agents; Quinoxalines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Timolol | 2002 |
Inhibition by brimonidine of forskolin-induced nitrite production in isolated pig ciliary processes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Ciliary Body; Colforsin; Dose-Response Relationship, Drug; GTP-Binding Protein alpha Subunits, Gi-Go; Nitrites; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine; Virulence Factors, Bordetella | 2002 |
Sympathetic denervation-induced changes in G protein expression in enteric neurons of the guinea pig colon.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Autonomic Denervation; Benzeneacetamides; Brimonidine Tartrate; Cell Fractionation; Colon; Drug Antagonism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Myenteric Plexus; Pertussis Toxin; Pyrrolidines; Quinoxalines; Receptors, Opioid; Synaptosomes; Virulence Factors, Bordetella | 2002 |
An economic analysis of switching to latanoprost from a beta-blocker or adding brimonidine or latanoprost to a beta-blocker in open-angle glaucoma or ocular hypertension.
Topics: Adrenergic beta-Antagonists; Aged; Analysis of Variance; Antihypertensive Agents; Brimonidine Tartrate; Chi-Square Distribution; Drug Costs; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Latanoprost; Male; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies | 2002 |
Discontinuation rates of topical glaucoma medications in a managed care population.
Topics: Administration, Topical; Adult; Antihypertensive Agents; Brimonidine Tartrate; Chi-Square Distribution; Female; Glaucoma; Humans; Latanoprost; Male; Middle Aged; Ophthalmic Solutions; Patient Compliance; Proportional Hazards Models; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Survival Analysis; Timolol | 2002 |
Beta 3-adrenoceptor in rat aorta: molecular and biochemical characterization and signalling pathway.
Topics: Animals; Aorta, Thoracic; Brimonidine Tartrate; Endothelium, Vascular; GTP-Binding Proteins; Immunohistochemistry; Male; Pertussis Toxin; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, beta-3; RNA, Messenger; Tetrahydronaphthalenes; Vasodilation | 2002 |
Formulation effects on ocular absorption of brimonidine in rabbit eyes.
Topics: Absorption; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Aqueous Humor; Area Under Curve; Benzalkonium Compounds; Biological Availability; Brimonidine Tartrate; Chromatography, Liquid; Cross-Over Studies; Female; Hydrogen-Ion Concentration; Mass Spectrometry; Ophthalmic Solutions; Preservatives, Pharmaceutical; Quinoxalines; Rabbits | 2002 |
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Endotoxemia; Enzyme Activation; Hemorrhage; Male; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroimmunomodulation; Neutrophils; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phentolamine; Phenylephrine; Phosphorylation; Propranolol; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Quinoxalines; Respiratory Distress Syndrome; Ribosomal Protein S6 Kinases | 2002 |
Acute and chronic NOS inhibition enhances alpha(2)- adrenoreceptor-stimulated RhoA and Rho kinase in rat aorta.
Topics: Adrenergic alpha-Agonists; Amides; Animals; Aorta; Brimonidine Tartrate; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Penicillamine; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; rho-Associated Kinases; rhoA GTP-Binding Protein; Vasoconstriction | 2002 |
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrphostins | 2002 |
Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma.
Topics: Administration, Topical; Aged; Antihypertensive Agents; Betaxolol; Blood Flow Velocity; Brimonidine Tartrate; Eye; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Ophthalmic Solutions; Prostaglandins F, Synthetic; Pulsatile Flow; Quinoxalines; Retrospective Studies; Tonometry, Ocular; Trabeculectomy | 2002 |
Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model.
Topics: Aging; Analysis of Variance; Animals; Antihypertensive Agents; Brimonidine Tartrate; Cell Survival; Disease Models, Animal; Glaucoma; Memantine; Mice; Mice, Inbred DBA; Quinoxalines; Retinal Ganglion Cells; Timolol | 2002 |
Effect of a long-duration physical exercise on fat cell lipolytic responsiveness to adrenergic agents and insulin in obese men.
Topics: Abdomen; Adipocytes; Adrenergic Agonists; Adult; Brimonidine Tartrate; Epinephrine; Exercise; Humans; Insulin; Isoproterenol; Lipolysis; Male; Obesity; Quinoxalines; Time Factors | 2002 |
Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Brimonidine Tartrate; Calcium; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endothelin Receptor Antagonists; Endothelium, Vascular; Horses; Imidazoles; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oligopeptides; Peptides, Cyclic; Phenylephrine; Piperidines; Quinoxalines | 2002 |
Effect of brimonidine on patients undergoing uncontrolled IOP with beta-blockers.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Chronic Disease; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Prospective Studies; Quinoxalines; Treatment Failure | 2002 |
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Homeostasis; Hypoglycemic Agents; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Ligands; Male; Mice; Mice, Inbred CBA; Piperazines; Quinoxalines; Receptors, Drug; Time Factors; Vas Deferens | 2002 |
Alpha 2-Adrenergic stimulation is protective against ischemia-reperfusion-induced ventricular arrhythmias in vivo.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Brimonidine Tartrate; Disease Models, Animal; Electrocardiography; Female; Heart Rate; Kidney; Male; Myocardial Ischemia; Myocardial Reperfusion; Quinoxalines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sympathetic Nervous System; Tachycardia, Ventricular; Ventricular Fibrillation | 2002 |
Endothelial inhibitory modulation on the contractile responses to alpha 2-adrenergic agonists.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxymetazoline; Quinoxalines; Rats; Rats, Wistar | 2002 |
Vasocontractile effects of alpha 2-adrenergic agonists associated with intracellular calcium release.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Oxymetazoline; Phenylephrine; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction | 2002 |
Changes of the excitability of rat trigeminal root ganglion neurons evoked by alpha(2)-adrenoreceptors.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Brimonidine Tartrate; Cell Membrane; Cells, Cultured; Clonidine; Gene Expression Regulation; Ion Channels; Neural Inhibition; Neurons, Afferent; Protein Isoforms; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; RNA, Messenger; Trigeminal Ganglion; Trigeminal Neuralgia | 2002 |
Beta-adrenoceptor-induced inhibition of rat splenocyte proliferation: cytokine gene transcription as the target of action.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Brimonidine Tartrate; Concanavalin A; In Vitro Techniques; Interleukin-2; Isoproterenol; Lymphocyte Activation; Male; Methoxamine; Quinoxalines; Rats; Receptors, Adrenergic, beta; RNA, Messenger; Spleen; Transcription, Genetic | 2002 |
Presynaptic effects of moxonidine in isolated buffer perfused rat hearts: role of imidazoline-1 receptors and alpha2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Bridged-Ring Compounds; Brimonidine Tartrate; Buffers; Dose-Response Relationship, Drug; Heart; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Indomethacin; Male; Norbornanes; Norepinephrine; Perfusion; Presynaptic Terminals; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Thiocarbamates; Thiones; Yohimbine | 2002 |
A paradoxical ocular effect of brimonidine.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Quinoxalines | 2003 |
Transient ischemia of the retina results in altered retrograde axoplasmic transport: neuroprotection with brimonidine.
Topics: Animals; Axonal Transport; Axons; Brimonidine Tartrate; Female; Fluorescent Dyes; In Vitro Techniques; Ischemic Attack, Transient; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Retina | 2002 |
Neurotransmitter release and its presynaptic modulation in the rat hippocampus after selective damage to cholinergic or/and serotonergic afferents.
Topics: 5,7-Dihydroxytryptamine; Acetylcholine; Adrenergic alpha-Agonists; Animals; Antibodies, Monoclonal; Biogenic Monoamines; Brimonidine Tartrate; Choline O-Acetyltransferase; Cholinergic Agents; Cholinergic Fibers; Electric Stimulation; Hippocampus; Immunotoxins; Male; N-Glycosyl Hydrolases; Neurons, Afferent; Neurotoxins; Nicotine; Nicotinic Agonists; Norepinephrine; Organ Culture Techniques; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Long-Evans; Ribosome Inactivating Proteins, Type 1; Saporins; Serotonin; Serotonin Agents; Serotonin Receptor Agonists | 2003 |
Brimonidine and latanoprost as adjunctive therapy.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Chemotherapy, Adjuvant; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Prostaglandins F, Synthetic; Quality of Life; Quinoxalines; Randomized Controlled Trials as Topic | 2003 |
Nitric oxide discriminates the sites and mechanisms of action of centrally acting anti-hypertensive drugs in rabbits.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Dose-Response Relationship, Drug; Imidazoline Receptors; Male; Medulla Oblongata; Neural Pathways; Nitric Oxide; Nordefrin; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Solitary Nucleus | 2002 |
Evaluation of the intraocular pressure-reducing effect of latanoprost as monotherapy in open-angle glaucoma.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 2002 |
Consultation section. Refractive surgical problem: 3 issues to be discussed: the clinical indications, the surgical procedure, the postoperative findings.
Topics: Adult; Brimonidine Tartrate; Contact Lenses; Corneal Topography; Diplopia; Drug Administration Schedule; Humans; Keratomileusis, Laser In Situ; Male; Myopia; Ophthalmic Solutions; Pilocarpine; Quinoxalines; Surgical Flaps; Vision Disorders | 2003 |
Effect of 0.2% brimonidine on retinal blood flow.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Glaucoma, Open-Angle; Humans; Middle Aged; Ophthalmic Solutions; Quinoxalines; Regional Blood Flow; Retinal Vessels | 2001 |
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Azepines; Brimonidine Tartrate; Clonidine; Idazoxan; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxazoles; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Yohimbine | 2002 |
[Clinical efficacy of 0.2% brimonidine in patients with open-angle glaucoma or ocular hypertension].
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Humans; Male; Middle Aged; Ocular Hypertension; Ophthalmic Solutions; Prospective Studies; Quinoxalines | 2002 |
alpha2C-Adrenoceptor blockade by clozapine and other antipsychotic drugs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Clozapine; Cricetinae; Cyclic AMP; Dibenzothiazepines; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Gene Expression; Haloperidol; Humans; Isoxazoles; Norepinephrine; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Quinolones; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Risperidone; Thiazoles; Transfection; Yohimbine | 2003 |
Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium.
Topics: Animals; ATP-Binding Cassette Transporters; Brimonidine Tartrate; Calcium; Chlorides; Chromatography, High Pressure Liquid; Colon; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; GTP-Binding Proteins; In Vitro Techniques; Intestinal Mucosa; Ion Channels; KATP Channels; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Norepinephrine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinoxalines; Radioimmunoassay; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
alpha 2-Adrenoceptors potentiate angiotensin II- and vasopressin-induced renal vasoconstriction in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Angiotensin II; Animals; Blotting, Western; Brimonidine Tartrate; Capillaries; Drug Synergism; GTP-Binding Protein alpha Subunits, Gi-Go; In Vitro Techniques; Male; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Receptors, Vasopressin; Renal Circulation; Signal Transduction; Vasoconstrictor Agents; Vasopressins | 2003 |
[Increased myopia and metaporphosia in a 59-year old patient. Serous retinal detachment of the posterior pol after latanoprost administration].
Topics: Antihypertensive Agents; Blood-Retinal Barrier; Brimonidine Tartrate; Diagnosis, Differential; Drug Therapy, Combination; Fluorescein Angiography; Glaucoma; Humans; Latanoprost; Male; Middle Aged; Myopia; Prostaglandins F, Synthetic; Quinoxalines; Retinal Detachment; Visual Acuity | 2003 |
Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304).
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Biological Transport; Brimonidine Tartrate; Calcium; Carrier Proteins; COS Cells; Male; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Quinoxalines; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptosomes | 2003 |
Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Blotting, Western; Body Weight; Brimonidine Tartrate; Carotid Arteries; Cells, Cultured; Cytosol; Endothelium, Vascular; Enzyme Inhibitors; Isoproterenol; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; omega-N-Methylarginine; Organ Size; Physical Conditioning, Animal; Quinoxalines; Rats; Rats, Inbred WKY; Receptors, Adrenergic, beta; Vasodilator Agents | 2003 |
A 24-day old with episodic lethargy, hypotonia, and apnea: the eyes have it.
Topics: Adrenergic alpha-Agonists; Apnea; Brimonidine Tartrate; Cataract; Humans; Infant, Newborn; Male; Muscle Hypotonia; Quinoxalines; Sleep Stages | 2003 |
Characterization of alpha2-adrenoceptors in smooth muscles of the spontaneously hypertensive rat aorta.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Calcium Channels; Female; In Vitro Techniques; Membrane Potentials; Muscle, Smooth, Vascular; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 2003 |
Role of the alpha2-adrenoceptors on the pulmonary circulation in the ovine fetus.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Enzyme Inhibitors; Female; Gestational Age; Nitric Oxide Synthase; Nitroarginine; Norepinephrine; Pregnancy; Pulmonary Circulation; Quinoxalines; Receptors, Adrenergic, alpha-2; Sheep; Yohimbine | 2003 |
Cystoid macular oedema associated with brimonidine therapy.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Female; Fluorescein Angiography; Glaucoma; Humans; Macular Edema; Quinoxalines | 2003 |
Dissimilar pharmacological responses by a new series of imidazoline derivatives at precoupled and ligand-activated alpha 2A-adrenoceptor states: evidence for effector pathway-dependent differential antagonism.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Benzopyrans; Binding Sites; Brimonidine Tartrate; CHO Cells; Cricetinae; Cyclic AMP; Epinephrine; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Idazoxan; Imidazoles; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Sulfur Radioisotopes; Tumor Cells, Cultured | 2003 |
Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Cholinesterase Inhibitors; Dialysis; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Idazoxan; Piribedil; Prefrontal Cortex; Quinolines; Quinoxalines; Rats; Rats, Wistar | 2003 |
Pharmacological evidence of a role for prejunctional imidazoline (I(1)) receptors in ocular function.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Brimonidine Tartrate; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Imidazoline Receptors; Nictitating Membrane; Ocular Physiological Phenomena; Platelet Aggregation Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 2002 |
Miotic effect of alphagan P.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Female; Glaucoma, Angle-Closure; Humans; Intraocular Pressure; Iris Diseases; Pupil; Quinoxalines | 2003 |
Hypotension and bradycardia in infants after the use of topical brimonidine and beta-blockers.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Bradycardia; Brimonidine Tartrate; Female; Glaucoma; Humans; Hypotension; Infant; Infant, Newborn; Intraocular Pressure; Quinoxalines | 2003 |
Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs.
Topics: Animals; Antihypertensive Agents; Aorta; Blotting, Western; Brimonidine Tartrate; Coronary Circulation; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Gene Expression Regulation, Enzymologic; Isometric Contraction; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Potassium Chloride; Quinoxalines; RNA, Messenger; Sexual Maturation; Swine; Testosterone; Vasoconstriction; Vasodilation | 2003 |
Enhancement of alpha2-adrenoceptor-mediated vasoconstriction by the thromboxane-mimetic U46619 in the porcine isolated ear artery: role of the ERK-MAP kinase signal transduction cascade.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Calcium; Ear; Enzyme Activation; Flavonoids; In Vitro Techniques; Mitogen-Activated Protein Kinases; Molecular Mimicry; Muscle, Smooth, Vascular; Phosphorylation; Quinoxalines; Receptors, Adrenergic, alpha-2; Signal Transduction; Swine; Thromboxanes; Vasoconstriction | 2003 |
Presynaptic modulation of acetylcholine, noradrenaline, and serotonin release in the hippocampus of aged rats with various levels of memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Analysis of Variance; Animals; Behavior, Animal; Brimonidine Tartrate; Choline O-Acetyltransferase; Female; Hippocampus; Idazoxan; In Vitro Techniques; Maze Learning; Memory Disorders; Methiothepin; Muscarinic Agonists; Norepinephrine; Oxotremorine; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Rats; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Swimming; Tritium | 2003 |
Presynaptic regulation of neurotransmitter release in the cortex of aged rats with differential memory impairments.
Topics: Acetylcholine; Acetylcholinesterase; Adrenergic alpha-Agonists; Aging; Animals; Brimonidine Tartrate; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Chromatography, High Pressure Liquid; Electric Stimulation; Female; Maze Learning; Memory Disorders; Muscarinic Agonists; Neurotransmitter Agents; Norepinephrine; Oxotremorine; Pyridines; Pyrroles; Quinoxalines; Rats; Rats, Long-Evans; Receptors, Presynaptic; Serotonin; Serotonin Receptor Agonists | 2003 |
Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes.
Topics: Adrenal Glands; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium Signaling; Catecholamines; Cells, Cultured; Chromaffin Cells; Epinephrine; Exocytosis; Feedback, Physiological; Mice; Mice, Knockout; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System; Tyrosine 3-Monooxygenase | 2003 |
Altered prejunctional modulation of intestinal cholinergic and noradrenergic pathways by alpha2-adrenoceptors in the presence of experimental colitis.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Colitis; Colon; Dinitrofluorobenzene; Electric Stimulation; Enteric Nervous System; Gastrointestinal Motility; Gastrointestinal Transit; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; Yohimbine | 2003 |
Effect of puberty on coronary arteries from female pigs.
Topics: Adrenergic alpha-Agonists; Animals; Arteries; Blotting, Western; Bradykinin; Brimonidine Tartrate; Computer Systems; Coronary Vessels; Endothelium-Dependent Relaxing Factors; Female; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Quinoxalines; RNA, Messenger; Swine; Vasodilation; Vasodilator Agents | 2003 |
Charles Bonnet syndrome precipitated by brimonidine tartrate eye drops.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Female; Hallucinations; Humans; Male; Ophthalmic Solutions; Quinoxalines; Syndrome | 2003 |
Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.
Topics: Animals; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Calcium; Carteolol; Cell Death; Dose-Response Relationship, Drug; Epinephrine; Glaucoma; Glutamic Acid; Latanoprost; Mice; Neuroblastoma; Neurons; Neuroprotective Agents; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiazines; Thiophenes; Timolol; Tumor Cells, Cultured | 2003 |
DPDPE-UK14,304 synergy is retained in mu opioid receptor knockout mice.
Topics: Animals; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Quinoxalines; Receptors, Opioid, mu; Spinal Cord | 2003 |
Granulomatous anterior uveitis associated with 0.2% topical brimonidine.
Topics: Administration, Topical; Aged; Antihypertensive Agents; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Granuloma; Humans; Quinoxalines; Uveitis, Anterior | 2003 |
Does topical brimonidine tartrate help NAION?
Topics: Administration, Topical; Adrenergic alpha-Agonists; Brimonidine Tartrate; Color Vision Defects; Humans; Ophthalmic Solutions; Optic Neuropathy, Ischemic; Quinoxalines; Retrospective Studies; Treatment Failure; Vision Disorders; Visual Acuity | 2003 |
Patient persistency with pharmacotherapy in the management of glaucoma.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Cohort Studies; Drug Utilization; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Middle Aged; Ocular Hypertension; Patient Compliance; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Sulfonamides; Thiophenes | 2003 |
Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor.
Topics: Adrenergic Agonists; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Catecholamines; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Ligands; Membrane Proteins; Models, Molecular; Molecular Structure; Mutation; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 2003 |
Dermatological side effects of brimonidine: a report of three cases.
Topics: Administration, Topical; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Dermatitis, Allergic Contact; Diagnosis, Differential; Facial Dermatoses; Female; Glaucoma, Open-Angle; Humans; Lichen Planus; Male; Nail Diseases; Ocular Hypertension; Ophthalmic Solutions; Patch Tests; Quinoxalines | 2003 |
Bilateral simultaneous anterior ischemic optic neuropathy in a young, healthy man.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Aspirin; Brimonidine Tartrate; Drug Therapy, Combination; Humans; Intraocular Pressure; Male; Optic Neuropathy, Ischemic; Quinoxalines; Visual Acuity; Visual Field Tests; Visual Fields | 2003 |
All three alpha2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Brimonidine Tartrate; Cattle; Cells, Cultured; Drug Interactions; Female; Ganglia, Sympathetic; Gene Expression; Heart Atria; Hippocampus; Male; Medetomidine; Mice; Mice, Inbred C57BL; Mice, Knockout; Occipital Lobe; Parietal Lobe; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Sympathetic Fibers, Postganglionic; Vas Deferens | 2003 |
Prescription of topical antiglaucoma agents for patients with contraindications to beta-blockers.
Topics: Administration, Topical; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Contraindications; Databases, Factual; Drug Prescriptions; Female; Glaucoma; Humans; Latanoprost; Male; Middle Aged; National Health Programs; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quebec; Quinoxalines; Retrospective Studies; Sulfonamides; Thiophenes; Timolol | 2003 |
Norepinephrine activates extracellular-regulated kinase in cortical neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Brimonidine Tartrate; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Extracellular Space; Female; Isoproterenol; Male; Mitogen-Activated Protein Kinases; Neurons; Norepinephrine; Pertussis Toxin; Phosphorylation; Prazosin; Pregnancy; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Yohimbine | 2003 |
Role of membrane potential and expression of endothelial factors in restenosis after angioplasty in SHR.
Topics: Adrenergic alpha-Agonists; Angioplasty, Balloon; Animals; Arterial Occlusive Diseases; Brimonidine Tartrate; Carotid Arteries; Endothelin-1; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; Membrane Potentials; Nitric Oxide; Peptides; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Wistar | 2004 |
Influence of alpha2-autoreceptor stimulation on the facilitation by angiotensin II and bradykinin of noradrenaline release.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Alkaloids; Angiotensin II; Animals; Animals, Newborn; Autoreceptors; Benzophenanthridines; Bradykinin; Brimonidine Tartrate; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Heart; In Vitro Techniques; Norepinephrine; Phenanthridines; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar | 2003 |
Ocular and systemic side effects of brimonidine 0.2% eye drops (Alphagan) in children.
Topics: Adolescent; Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Child; Child, Preschool; Eye Diseases; Female; Glaucoma; Humans; Infant; Infant, Newborn; Male; Ophthalmic Solutions; Quinoxalines; Sleep Stages; Syncope | 2004 |
Noradrenaline inhibits autonomous activity in the isolated guinea pig bladder.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Brimonidine Tartrate; Electric Stimulation; Female; Guinea Pigs; Imidazoles; Muscle Contraction; Norepinephrine; Quinoxalines; Receptors, Adrenergic; Urinary Bladder | 2004 |
Transient ischemia of the retina results in massive degeneration of the retinotectal projection: long-term neuroprotection with brimonidine.
Topics: Afferent Pathways; Animals; Axonal Transport; Brain Stem; Brimonidine Tartrate; Cholera Toxin; Eye; Female; Functional Laterality; Image Processing, Computer-Assisted; Immunohistochemistry; Ischemia; Mesencephalon; Nerve Degeneration; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Staining and Labeling | 2003 |
Role of alpha2-adrenergic receptors and cyclic adenosine monophosphate-dependent protein kinase in the regulation of norepinephrine release in the central nervous system of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Central Nervous System; Clonidine; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; GTP-Binding Protein alpha Subunits, Gi-Go; Hypertension; Isoquinolines; Male; Medulla Oblongata; Norepinephrine; Pertussis Toxin; Presynaptic Terminals; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2003 |
Brimonidine and latanoprost as adjunctive therapy.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 2004 |
No evidence for activation of alpha(2)-adrenoceptors by methanolic extracts of bovine brain and lung containing clonidine-displacing substance.
Topics: Adrenergic alpha-Agonists; Animals; Brain Chemistry; Brimonidine Tartrate; Cattle; Clonidine; Colforsin; Cyclic AMP; Guinea Pigs; In Vitro Techniques; Lung; Male; Methanol; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Swine; Tissue Extracts; Vas Deferens; Veins | 2003 |
Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Bridged Bicyclo Compounds; Brimonidine Tartrate; Drug Synergism; Heart; Heptanes; Imidazoles; Imidazoline Receptors; Norepinephrine; Oxazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Sympatholytics; Yohimbine | 2003 |
Tonopen measurement of intraocular pressure in mice.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Catheterization; Intraocular Pressure; Manometry; Mice; Mice, Inbred C57BL; Models, Animal; Quinoxalines; Rats; Rats, Inbred BN; Reproducibility of Results | 2004 |
Charles Bonnet syndrome and brimonidine: comments.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Hallucinations; Humans; Ophthalmic Solutions; Quinoxalines; Syndrome | 2004 |
Demographic and clinical factors associated with development of brimonidine tartrate 0.2%-induced ocular allergy.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Conjunctivitis, Allergic; Demography; Dermatitis, Allergic Contact; Drug Hypersensitivity; Eyelid Diseases; Female; Glaucoma; Humans; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Retrospective Studies; Risk Factors | 2004 |
Adrenoceptor agonist poisoning after accidental oral ingestion of brimonidine eye drops.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Brimonidine Tartrate; Child, Preschool; Humans; Male; Metabolic Clearance Rate; Ophthalmic Solutions; Quinoxalines | 2004 |
Trends in glaucoma surgery before and after the introduction of new topical glaucoma pharmacotherapies.
Topics: Administration, Topical; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy; Drug Utilization; Filtering Surgery; Glaucoma, Open-Angle; Humans; Inpatients; Latanoprost; Medicare; Ophthalmic Solutions; Outpatients; Prevalence; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; United States | 2004 |
alpha2-Adrenergic receptor-mediated modulation of calcium current in neocortical pyramidal neurons.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Clonidine; GTP-Binding Proteins; Neocortex; Norepinephrine; Patch-Clamp Techniques; Pertussis Toxin; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine | 2004 |
The role of Rho kinase and extracellular regulated kinase-mitogen-activated protein kinase in alpha2-adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein.
Topics: Amides; Animals; Brimonidine Tartrate; Drug Interactions; Flavonoids; Intracellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Myosin Light Chains; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Quinoxalines; Receptors, Adrenergic, alpha-2; rho-Associated Kinases; Swine; Vasoconstriction; Veins | 2004 |
The effect of daily use of brimonidine tartrate on the dark-adapted pupil diameter.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Dark Adaptation; Humans; Mydriasis; Ophthalmic Solutions; Pupil; Quinoxalines; Recurrence; Tachyphylaxis | 2004 |
Anterior uveitis and concurrent allergic conjunctivitis associated with long-term use of topical 0.2% brimonidine tartrate.
Topics: Administration, Topical; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Conjunctivitis, Allergic; Female; Glaucoma; Glucocorticoids; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Prednisolone; Quinoxalines; Uveitis, Anterior | 2004 |
Alphagan allergy may increase the propensity for multiple eye-drop allergy.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Cross Reactions; Drug Administration Schedule; Drug Hypersensitivity; Female; Glaucoma; Glaucoma, Open-Angle; Humans; Longitudinal Studies; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Retrospective Studies; Sulfonamides; Thiophenes; Timolol | 2005 |
An unusual appearance of limbal conjunctival follicles in a patient on brimonidine and dorzolamide.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Conjunctival Diseases; Glaucoma, Open-Angle; Humans; Male; Quinoxalines; Sulfonamides; Thiophenes | 2005 |
Prospective survey of adverse reactions to topical antiglaucoma medications in a hospital population.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Female; Filtering Surgery; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Outpatient Clinics, Hospital; Patient Acceptance of Health Care; Prospective Studies; Quinoxalines; Time Factors | 2005 |
Effect of brimonidine tartrate 0.2% ophthalmic solution on pupil size.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Dark Adaptation; Eye Color; Female; Humans; Light; Male; Middle Aged; Ophthalmic Solutions; Pupil; Quinoxalines | 2004 |
Effects of the preservative purite on the bioavailability of brimonidine in the aqueous humor of rabbits.
Topics: Animals; Aqueous Humor; Benzalkonium Compounds; Biological Availability; Brimonidine Tartrate; Chemistry, Pharmaceutical; Drug Interactions; Female; Preservatives, Pharmaceutical; Quinoxalines; Rabbits | 2004 |
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Endocardium; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Hemodynamics; Hypertrophy, Left Ventricular; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium Channels; Quinoxalines; Swine; Vascular Resistance; Vasodilation | 2004 |
[Neuroprotection and vasoprotection in glaucoma].
Topics: Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Carteolol; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Neuroprotective Agents; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Treatment Outcome | 2004 |
Chronic morphine treatment reduces recovery from opioid desensitization.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cocaine; Drug Tolerance; Enkephalin, Methionine; Leucine; Locus Coeruleus; Male; Monensin; Morphine; Morphine Dependence; Morphine Derivatives; Norepinephrine; Phosphorylation; Prazosin; Protein Kinase C; Protein Processing, Post-Translational; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Staurosporine; Thiorphan; Yohimbine | 2004 |
Ligand-induced alpha2-adrenoceptor endocytosis: relationship to Gi protein activation.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Cell Line; Clonidine; Dexmedetomidine; Endocytosis; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2 | 2004 |
Lys-[Leu8,des-Arg9]-bradykinin blocks lipopolysaccharide-induced SHR aorta hyperpolarization by inhibition of Ca(++)- and ATP-dependent K+ channels.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Aorta, Thoracic; Bradykinin; Brimonidine Tartrate; Cromakalim; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Kallidin; Lipopolysaccharides; Male; Membrane Potentials; Peptides; Potassium Channels, Calcium-Activated; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Wistar; Vasodilator Agents | 2004 |
Regulation of cAMP levels in area CA1 of hippocampus by Gi/o-coupled receptors is stimulus dependent in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Analysis of Variance; Animals; Baclofen; Brimonidine Tartrate; Calcium; Cyclic AMP; Dopamine Agonists; Drug Interactions; Excitatory Amino Acid Agonists; GABA Agonists; GTP-Binding Protein alpha Subunits, Gi-Go; Hippocampus; In Vitro Techniques; Isoproterenol; Male; Mice; Mice, Inbred C57BL; N-Methylaspartate; Quinoxalines; Quinpirole; Radioimmunoassay; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Serotonin Receptor Agonists | 2004 |
Phenylpropanolamine constricts mouse and human blood vessels by preferentially activating alpha2-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Endothelium, Vascular; Humans; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Phenylpropanolamine; Quinoxalines; Regional Blood Flow; Skin; Tail; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2005 |
Involvement of G i/o proteins in nerve growth factor-stimulated phosphorylation and degradation of tuberin in PC-12 cells and cortical neurons.
Topics: Animals; Brimonidine Tartrate; Cell Survival; Cerebral Cortex; Glycine; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Nerve Growth Factor; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Repressor Proteins; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2005 |
Effect of tumor necrosis factor-alpha on the reciprocal G-protein-induced regulation of norepinephrine release by the alpha2-adrenergic receptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azides; Brimonidine Tartrate; Cell Membrane; Dose-Response Relationship, Drug; Drug Interactions; Electrophoresis, Polyacrylamide Gel; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Guanosine Triphosphate; Hippocampus; In Vitro Techniques; Male; Norepinephrine; Pertussis Toxin; Phenoxybenzamine; Phosphorus Isotopes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tumor Necrosis Factor-alpha; Yohimbine | 2005 |
Intravitreal triamcinolone injection for diabetic macular edema: a clinical and fluorescein angiographic case series.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Diabetic Retinopathy; Female; Fluorescein Angiography; Glucocorticoids; Humans; Injections; Intraocular Pressure; Laser Coagulation; Macular Edema; Male; Middle Aged; Pilot Projects; Quinoxalines; Retrospective Studies; Triamcinolone Acetonide; Visual Acuity; Vitreous Body | 2004 |
Bilateral retinal venous occlusion in pigmentary glaucoma.
Topics: Adult; Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Exfoliation Syndrome; Functional Laterality; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Quinoxalines; Retinal Vein Occlusion; Timolol; Trabecular Meshwork; Vision Disorders; Visual Field Tests; Visual Fields | 2005 |
Polycarboxylic acid nanoparticles for ophthalmic drug delivery: an ex vivo evaluation with human cornea.
Topics: Acrylates; Antihypertensive Agents; Brimonidine Tartrate; Carboxylic Acids; Cells, Cultured; Delayed-Action Preparations; Drug Compounding; Epithelial Cells; Epithelium, Corneal; Humans; Hydrogels; Hydrogen-Ion Concentration; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanostructures; Nanotechnology; Polymers; Quinoxalines; Succinates | 2004 |
Influence of the membrane lipid structure on signal processing via G protein-coupled receptors.
Topics: Animals; Brimonidine Tartrate; Dose-Response Relationship, Drug; Membrane Lipids; Mice; NIH 3T3 Cells; Protein Binding; Quinoxalines; Receptors, G-Protein-Coupled; Signal Transduction | 2005 |
An antidepressant mechanism of desipramine is to decrease tumor necrosis factor-alpha production culminating in increases in noradrenergic neurotransmission.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Blotting, Northern; Brimonidine Tartrate; Clonidine; Desipramine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Freezing Reaction, Cataleptic; Gene Expression Regulation; In Vitro Techniques; Male; Neural Inhibition; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Swimming; Time Factors; Tumor Necrosis Factor-alpha; Yohimbine | 2005 |
Two "knockout" mouse models demonstrate that aortic vasodilatation is mediated via alpha2a-adrenoceptors located on the endothelium.
Topics: Animals; Aorta, Thoracic; Brimonidine Tartrate; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Dyes; Image Processing, Computer-Assisted; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Myography; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Quinoxalines; Receptors, Adrenergic, alpha-2; Vasoconstrictor Agents; Vasodilation | 2005 |
Cost considerations of the new fixed combinations for glaucoma medical therapy.
Topics: Administration, Topical; Antihypertensive Agents; Brimonidine Tartrate; Canada; Drug Combinations; Glaucoma; Humans; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes; Timolol | 2005 |
Mechanism of the vascular angiotensin II/alpha2-adrenoceptor interaction.
Topics: Angiotensin II; Animals; Brimonidine Tartrate; CSK Tyrosine-Protein Kinase; Isoenzymes; Kidney; Male; Phosphatidylinositol 3-Kinases; Phospholipase C beta; Protein Kinase C; Protein-Tyrosine Kinases; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; src-Family Kinases; Type C Phospholipases; Vascular Resistance | 2005 |
Oxytocin increases the density of high affinity alpha(2)-adrenoceptors within the hypothalamus, the amygdala and the nucleus of the solitary tract in ovariectomized rats.
Topics: Adrenergic alpha-Agonists; Amygdala; Animals; Autoradiography; Binding Sites; Brimonidine Tartrate; Dose-Response Relationship, Drug; Female; Hypothalamus; Ovariectomy; Oxytocin; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Solitary Nucleus; Tritium | 2005 |
alpha(2)-Adrenoceptor involvement in the in vitro inhibitory effect of citalopram on a subpopulation of rat locus coeruleus neurons.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amphetamines; Animals; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Idazoxan; In Vitro Techniques; Locus Coeruleus; Male; Methiothepin; Naloxone; Narcotic Antagonists; Neurons; Norepinephrine; Oxazines; Piperazines; Piperidines; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Thiophenes | 2005 |
Loss of association between activated Galpha q and Gbetagamma disrupts receptor-dependent and receptor-independent signaling.
Topics: Acetylation; Adrenergic alpha-Agonists; Brimonidine Tartrate; Cell Line; Cell Membrane; Cyclic AMP; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Heterotrimeric GTP-Binding Proteins; Humans; Inositol Phosphates; Isoenzymes; Models, Biological; Mutagenesis, Site-Directed; Mutation; Palmitic Acid; Phospholipase C beta; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Signal Transduction; Transfection; Type C Phospholipases | 2005 |
Proteomic exploration of pancreatic islets in mice null for the alpha2A adrenergic receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amino Acid Sequence; Animals; Base Sequence; Blood Glucose; Brimonidine Tartrate; DNA; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Protein Processing, Post-Translational; Proteins; Proteomics; Quinoxalines; Receptors, Adrenergic, alpha-2; Sequence Homology, Nucleic Acid; Signal Transduction | 2005 |
Minimally invasive, direct, real time measurement of drug concentration in the anterior eye.
Topics: Absorption; Administration, Topical; Adult; Animals; Anterior Chamber; Brimonidine Tartrate; Contact Lenses; Cornea; Fluorescein; Humans; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Rabbits; Spectrometry, Fluorescence | 2005 |
Ischemia results 3 months later in altered ERG, degeneration of inner layers, and deafferented tectum: neuroprotection with brimonidine.
Topics: Animals; Brimonidine Tartrate; Electroretinography; Female; Ischemia; Ligation; Nerve Degeneration; Neuroprotective Agents; Ophthalmic Artery; Quinoxalines; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Retinal Ganglion Cells; Retinal Vessels; Superior Colliculi; Time Factors; Visual Pathways | 2005 |
Effects of a topical alpha2 adrenergic agonist on ciliary blood flow and aqueous production in rabbits.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Aqueous Humor; Blood Pressure; Brimonidine Tartrate; Ciliary Body; Cornea; Heart Rate; Intraocular Pressure; Laser-Doppler Flowmetry; Oxygen; Quinoxalines; Rabbits; Regional Blood Flow; Vasoconstrictor Agents | 2006 |
Side-effect profile of brimonidine tartrate in children.
Topics: Adolescent; Adrenergic alpha-Agonists; Brimonidine Tartrate; Central Nervous System Diseases; Child; Child, Preschool; Female; Glaucoma; Humans; Infant; Intraocular Pressure; Male; Prospective Studies; Quinoxalines; Risk Factors; Sleep; Sleep Stages; Surveys and Questionnaires | 2005 |
The effects of anesthetics and ethanol on alpha2 adrenoceptor subtypes expressed with G protein-coupled inwardly rectifying potassium channels in Xenopus oocytes.
Topics: Anesthetics; Animals; Brimonidine Tartrate; Ethanol; Female; Quinoxalines; Receptors, Adrenergic, alpha-2; Xenopus laevis | 2005 |
Effect of brimonidine on pupil diameter.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Dark Adaptation; Humans; Light; Ophthalmic Solutions; Pupil; Quinoxalines | 2005 |
Acute vibration increases alpha2C-adrenergic smooth muscle constriction and alters thermosensitivity of cutaneous arteries.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Muscle, Smooth, Vascular; Neuromuscular Diseases; Quinolizines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Skin; Tail; Vasoconstriction; Vibration | 2006 |
Characterization of brimonidine transport in retinal pigment epithelium.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Biological Transport, Active; Blood-Retinal Barrier; Brimonidine Tartrate; Calcium Channel Blockers; Carrier Proteins; Cattle; Cells, Cultured; Choroid; Hydrogen-Ion Concentration; Melanins; Pigment Epithelium of Eye; Quinoxalines; Retina; Temperature; Time Factors | 2006 |
Argon laser trabeculoplasty and reduction of ocular hypotensive medication used by glaucoma patients.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Chronic Disease; Circadian Rhythm; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Male; Middle Aged; Quinoxalines; Trabeculectomy; Treatment Outcome | 2006 |
Brimonidine evokes heterogeneous vasomotor response of retinal arterioles: diminished nitric oxide-mediated vasodilation when size goes small.
Topics: Adrenergic alpha-Agonists; Animals; Arterioles; Brimonidine Tartrate; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Male; Nitric Oxide; Quinoxalines; Receptors, Adrenergic, alpha-2; Retinal Artery; Swine; Vasodilation; Vasomotor System | 2006 |
Impairment of presynaptic alpha2-adrenoceptor-regulated norepinephrine overflow in failing hearts from Zucker diabetic fatty rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Body Weight; Brimonidine Tartrate; Diabetes Mellitus, Type 2; Electric Stimulation; Heart Failure; Heterozygote; Homozygote; Male; Norepinephrine; Organ Size; Perfusion; Quinoxalines; Rats; Rats, Zucker; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Yohimbine | 2006 |
Acute and long-term administration of citalopram desensitizes alpha2-adrenoceptors in the rat vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Citalopram; Dose-Response Relationship, Drug; Drug Administration Schedule; Duloxetine Hydrochloride; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Vas Deferens | 2006 |
[Ocular hypertension in children treated with brimonidine 0.2%. A clinical study].
Topics: Administration, Topical; Antihypertensive Agents; Brimonidine Tartrate; Child; Female; Glaucoma; Humans; Intraocular Pressure; Male; Ocular Hypertension; Quinoxalines; Retrospective Studies; Treatment Outcome | 2006 |
K(+)-evoked [(3)H]-norepinephrine release in human brain slices from epileptic and non-epileptic patients is differentially modulated by gabapentin and pinacidil.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Amines; Anticonvulsants; Brimonidine Tartrate; Calcium Channel Blockers; Child; Cyclohexanecarboxylic Acids; Epilepsy; Female; Gabapentin; gamma-Aminobutyric Acid; Hippocampus; Humans; Idazoxan; In Vitro Techniques; Male; Middle Aged; Norepinephrine; omega-Conotoxins; Pinacidil; Potassium; Quinoxalines; Time Factors; Tritium | 2006 |
A rat model for acute rise in intraocular pressure: immune modulation as a therapeutic strategy.
Topics: Acute Disease; Animals; Antihypertensive Agents; Brimonidine Tartrate; Cell Survival; Disease Models, Animal; Dizocilpine Maleate; Glatiramer Acetate; Immunization; Injections; Intraocular Pressure; Male; Neuroprotective Agents; Ocular Hypertension; Optic Nerve Diseases; Peptides; Quinoxalines; Rats; Rats, Inbred Lew; Retinal Ganglion Cells; Vaccination | 2006 |
Receptors involved in moxonidine-stimulated atrial natriuretic peptide release from isolated normotensive rat hearts.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Bridged Bicyclo Compounds; Brimonidine Tartrate; Clonidine; Coronary Circulation; Drug Synergism; Female; Heart; Heart Rate; Heptanes; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Myocardium; Perfusion; Phenoxybenzamine; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 2006 |
Is brimonidine ophthalmic a safe therapy for infants?
Topics: Adrenergic alpha-Agonists; Bradycardia; Brimonidine Tartrate; Glaucoma; Humans; Hypotension; Infant; Male; Ophthalmic Solutions; Quinoxalines | 2006 |
[Intraocular pressure after ND: YAG laser capsulotomy in pseudophakic patients with glaucoma].
Topics: Administration, Topical; Antihypertensive Agents; Brimonidine Tartrate; Cataract Extraction; Glaucoma; Humans; Intraocular Pressure; Laser Therapy; Lens Capsule, Crystalline; Preoperative Care; Pseudophakia; Quinoxalines; Sulfonamides; Thiophenes | 2006 |
Evidence against alpha-adrenoceptors mediating relaxation in rat thoracic aortae: alpha-agonists relaxation depends on interaction with alpha-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Azepines; Brimonidine Tartrate; Clonidine; Dinoprost; Dose-Response Relationship, Drug; Endothelium, Vascular; In Vitro Techniques; Male; Methoxamine; Nitric Oxide; Phenylephrine; Piperazines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Serotonin; Vasoconstrictor Agents; Vasodilation; Yohimbine | 2006 |
Vitreous concentration of topically applied brimonidine-purite 0.15%.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Antihypertensive Agents; Biological Availability; Brimonidine Tartrate; Female; Gas Chromatography-Mass Spectrometry; Humans; Male; Ophthalmic Solutions; Quinoxalines; Tissue Distribution; Vitrectomy; Vitreous Body | 2006 |
Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs.
Topics: Administration, Topical; Aged; Amides; Antihypertensive Agents; Bimatoprost; Brimonidine Tartrate; Carteolol; Case-Control Studies; Chemokines; Cloprostenol; Cytokines; Dose-Response Relationship, Immunologic; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Lipids; Male; Prospective Studies; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Tears; Thiophenes; Timolol | 2007 |
Allergic contact dermatitis caused by topical eye drops.
Topics: Administration, Topical; Antihypertensive Agents; Blepharitis; Brimonidine Tartrate; Dermatitis, Allergic Contact; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Latanoprost; Middle Aged; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines | 2006 |
Brimonidine/Timolol: a viewpoint by Richard Fiscella.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Quinoxalines; Randomized Controlled Trials as Topic; Timolol; Treatment Outcome | 2006 |
Brimonidine/Timolol: a viewpoint by Robert M. Feldman.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma; Humans; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 2006 |
Brimonidine/Timolol: a viewpoint by Francisco J. Goñi.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Drug Therapy, Combination; Glaucoma; Humans; Intraocular Pressure; Ocular Hypertension; Quinoxalines; Randomized Controlled Trials as Topic; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2006 |
Mechanisms underlying lysophosphatidylcholine-induced potentiation of vascular contractions in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat aorta.
Topics: Animals; Aorta, Thoracic; Brimonidine Tartrate; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Lysophosphatidylcholines; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Potassium; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinoxalines; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Receptors, G-Protein-Coupled; RNA, Messenger; Up-Regulation; Vanadates; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Antinociception mediated by alpha(2)-adrenergic activation involves increasing tumor necrosis factor alpha (TNFalpha) expression and restoring TNFalpha and alpha(2)-adrenergic inhibition of norepinephrine release.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Radiation; Electric Stimulation; Functional Laterality; Hippocampus; Hyperalgesia; In Situ Hybridization; In Vitro Techniques; Locus Coeruleus; Male; Norepinephrine; Pain Measurement; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sciatica; Tumor Necrosis Factor-alpha | 2007 |
Functional interaction between alpha2-adrenoceptors, mu- and kappa-opioid receptors in the guinea pig myenteric plexus: effect of chronic desipramine treatment.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Benzeneacetamides; Blotting, Western; Brimonidine Tartrate; Desipramine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; G Protein-Coupled Inwardly-Rectifying Potassium Channels; GTP-Binding Proteins; Guinea Pigs; In Vitro Techniques; Male; Myenteric Plexus; Peristalsis; Pyrrolidines; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synaptosomes | 2006 |
Neuroprotective effects of brimonidine treatment in a rodent model of ischemic optic neuropathy.
Topics: Adrenergic alpha-Agonists; Animals; Axons; Benzoxazines; Brimonidine Tartrate; Cell Survival; Coloring Agents; Disease Models, Animal; Drug Administration Schedule; Drug Evaluation, Preclinical; Neuroprotective Agents; Ophthalmic Solutions; Optic Neuropathy, Ischemic; Oxazines; Quinoxalines; Rats; Rats, Long-Evans; Retinal Ganglion Cells | 2007 |
The growth factor response in ischemic rat retina and superior colliculus after brimonidine pre-treatment.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Axons; Brain Ischemia; Brimonidine Tartrate; Cytoprotection; Disease Models, Animal; Gene Expression Regulation; Intercellular Signaling Peptides and Proteins; Male; Nerve Degeneration; Neuroprotective Agents; Optic Nerve; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Growth Factor; Retinal Ganglion Cells; RNA, Messenger; Superior Colliculi; Up-Regulation | 2006 |
Enaminones and norepinephrine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cyclohexanes; Dopamine; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Male; Neural Inhibition; Norepinephrine; Nucleus Accumbens; Phosphinic Acids; Prazosin; Propanolamines; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 2006 |
Electrophysiological properties of catecholaminergic neurons in the norepinephrine-deficient mouse.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Autoreceptors; Brimonidine Tartrate; Dopamine beta-Hydroxylase; Electric Stimulation; Enkephalin, Methionine; Locus Coeruleus; Mice; Mice, Inbred C57BL; Mice, Knockout; Neural Inhibition; Norepinephrine; Organ Culture Techniques; Patch-Clamp Techniques; Quinoxalines; Receptors, Adrenergic, alpha-2; Substantia Nigra; Synaptic Transmission | 2007 |
Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner.
Topics: Adrenergic beta-1 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; Calcium; Cyclic AMP; Imidazoles; Male; Mice; Norepinephrine; Phenylpropanolamine; Phosphorylation; Procaterol; Propanolamines; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-1; Sperm Capacitation; Spermatozoa; Tyrosine | 2007 |
Non-systemic delivery of topical brimonidine to the brain: a neuro-ocular tissue distribution study.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Animals; Brain; Brimonidine Tartrate; Data Interpretation, Statistical; Drug Delivery Systems; Eye; Functional Laterality; Male; Optic Nerve; Quinoxalines; Rabbits; Tissue Distribution; Visual Pathways | 2006 |
Effects of brimonidine ingestion on cardiovascular responses and renal function in conscious dogs.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Brimonidine Tartrate; Cardiovascular System; Dogs; Drug Interactions; Electrocardiography; Electrolytes; Female; Glomerular Filtration Rate; Heart Rate; Kidney; Male; p-Aminohippuric Acid; Quinoxalines; Renal Plasma Flow, Effective; Respiration; Yohimbine | 2007 |
Presynaptic alpha-adrenoceptors in median preoptic nucleus modulate inhibitory neurotransmission from subfornical organ and organum vasculosum lamina terminalis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cells, Cultured; Hypothalamus; Idazoxan; Imidazoles; Isoproterenol; Norepinephrine; Prazosin; Preoptic Area; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Signal Transduction; Subfornical Organ | 2007 |
Drug-induced ectropion: what is best practice?
Topics: Administration, Topical; Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Ectropion; Eyelids; Female; Glucocorticoids; Humans; Hydrocortisone; Male; Middle Aged; Quinoxalines; Retrospective Studies; Sulfonamides; Thiophenes | 2007 |
[Depression of respiration via toxic effects on the central nervous system following use of topical brimonidine in an infant with congenital glaucoma].
Topics: Antihypertensive Agents; Apnea; Brimonidine Tartrate; Cataract; Female; Glaucoma; Humans; Infant, Newborn; Infant, Premature, Diseases; Neurotoxicity Syndromes; Ophthalmic Solutions; Postoperative Complications; Quinoxalines; Respiratory Insufficiency; Trabeculectomy | 2007 |
Characterization of the postjunctional alpha 2C-adrenoceptor mediating vasoconstriction to UK14304 in porcine pulmonary veins.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Gene Expression; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Neuromuscular Junction; Norepinephrine; Piperazines; Prazosin; Pulmonary Veins; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Swine; Vasoconstriction; Yohimbine | 2007 |
Presynaptic modulation of 5-HT release in the rat septal region.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Brimonidine Tartrate; Calcium; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Male; Neurons; Presynaptic Terminals; Pyridines; Pyrroles; Quinoxalines; Quipazine; Rats; Rats, Wistar; Septum of Brain; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 2007 |
Inhibition by brimonidine of forskolin-induced nitric oxide synthase expression in human ciliary bodies in vitro.
Topics: Adrenergic alpha-Agonists; Blotting, Western; Brimonidine Tartrate; Ciliary Body; Colforsin; Cryopreservation; Humans; In Vitro Techniques; Nitric Oxide Synthase; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue and Organ Harvesting | 2007 |
Brimonidine for anisocoria.
Topics: Adrenergic alpha-Agonists; Adult; Anisocoria; Blepharoptosis; Brimonidine Tartrate; Female; Horner Syndrome; Humans; Quinoxalines; Treatment Outcome | 2007 |
Characterization of benzimidazole and other oxidative and conjugative metabolites of brimonidine in vitro and in rats in vivo using on-line HID exchange LC-MS/MS and stable-isotope tracer techniques.
Topics: Adrenergic alpha-Agonists; Aldehyde Oxidase; Animals; Benzimidazoles; Brimonidine Tartrate; Deuterium; Humans; Hydrogen; In Vitro Techniques; Male; Microsomes, Liver; Models, Biological; Quinoxalines; Rabbits; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry | 2007 |
Reduced ocular allergy with fixed-combination 0.2% brimonidine-0.5% timolol.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Clinical Trials as Topic; Conjunctivitis, Allergic; Drug Therapy, Combination; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Quinoxalines; Timolol | 2007 |
Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Animals; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Foot Diseases; Hindlimb; Horse Diseases; Horses; Methoxamine; Protein Kinase Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Serotonin, 5-HT1; rho-Associated Kinases; Serotonin; Serotonin Receptor Agonists; Vasoconstriction | 2007 |
The alpha2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amiloride; Animals; Anti-Arrhythmia Agents; Bicarbonates; Bile; Bile Duct Diseases; Bile Ducts, Intrahepatic; Brimonidine Tartrate; Chloride-Bicarbonate Antiporters; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Down-Regulation; Hepatocytes; Ligation; Liver; Male; Quinoxalines; Rats; Rats, Inbred F344; Receptors, Adrenergic, alpha-2; Secretin; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Yohimbine | 2007 |
Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes.
Topics: Adrenergic alpha-Agonists; Animals; Base Sequence; Blastocyst; Brimonidine Tartrate; Cell Count; Dose-Response Relationship, Drug; Female; Immunohistochemistry; Mice; Mice, Inbred ICR; Molecular Sequence Data; Morula; Oocytes; Ovulation; Pregnancy; Quinoxalines; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Physiological | 2007 |
EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by alpha(2A)-adrenoreceptor in intestinal epithelial cells: a role in wound healing.
Topics: ADAM Proteins; ADAM17 Protein; Brimonidine Tartrate; Caco-2 Cells; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Matrix Metalloproteinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinoxalines; Receptors, Adrenergic, alpha-2; Wound Healing | 2007 |
Neuroprotective effect of topically applied brimonidine tartrate 0.2% in endothelin-1-induced optic nerve ischaemia model.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Apoptosis; Brimonidine Tartrate; Cell Count; Disease Models, Animal; Endothelin-1; Infusion Pumps, Implantable; Neuroprotective Agents; Optic Neuropathy, Ischemic; Quinoxalines; Rabbits; Retina; Retinal Ganglion Cells | 2007 |
Alpha 2A-adrenoceptor-specific stimulation of [35S]GTP gamma S binding to membrane preparations of rat frontal cortex.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Clonidine; Emotions; Guanfacine; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoquinolines; Kinetics; Membranes; Naphthyridines; Prefrontal Cortex; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Signal Transduction; Stress, Psychological | 2008 |
Alpha 1-noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Betaxolol; Brain Chemistry; Brimonidine Tartrate; Cocaine-Related Disorders; Conditioning, Operant; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Motivation; Prazosin; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Self Administration; Septal Nuclei | 2008 |
Cystoid macular edema in a pseudophakic patient after switching from latanoprost to BAK-free travoprost.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Brimonidine Tartrate; Cloprostenol; Female; Humans; Instillation, Drug; Intraocular Pressure; Latanoprost; Macular Edema; Prednisolone; Prostaglandins F, Synthetic; Pseudophakia; Quinoxalines; Tomography, Optical Coherence; Travoprost; Treatment Outcome | 2007 |
Noradrenergic control of odor recognition in a nonassociative olfactory learning task in the mouse.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Association Learning; Benzopyrans; Benzylamines; Brimonidine Tartrate; Imidazoles; Male; Mental Recall; Mice; Mice, Inbred C57BL; Norepinephrine; Odorants; Prazosin; Propranolol; Quinoxalines; Recognition, Psychology; Smell | 2007 |
The presence of beta2-adrenoceptors sensitizes alpha2A-adrenoceptors to desensitization after chronic epinephrine treatment.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic beta-2 Receptor Antagonists; Brimonidine Tartrate; Cell Line, Tumor; Cell Membrane; Cyclic AMP; Epinephrine; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; Humans; Norepinephrine; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta-2; RNA, Messenger; Transfection | 2007 |
Drug modification of angiogenesis in a rat cornea model.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Corneal Neovascularization; Corneal Stroma; Disease Models, Animal; Drug Implants; Fibroblast Growth Factor 2; Latanoprost; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Sulfonamides; Thiophenes; Timolol | 2008 |
Noradrenergic vasoconstriction of pig prostatic small arteries.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Animals; Arteries; Brimonidine Tartrate; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Guanethidine; In Vitro Techniques; Indoles; Male; Norepinephrine; Piperazines; Prazosin; Prostate; Quinoxalines; Swine; Thymine; Vasoconstriction; Yohimbine | 2008 |
Normal-tension glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aging; Brimonidine Tartrate; Circadian Rhythm; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Quinoxalines; Timolol; Visual Fields | 2008 |
New drug information. Combigan.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Quinoxalines; Timolol | 2008 |
Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Brimonidine Tartrate; Clonidine; Data Interpretation, Statistical; Electric Stimulation; Enkephalins; Guanfacine; Immunohistochemistry; Male; Medetomidine; Microscopy, Confocal; Oligopeptides; Protease Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Veratridine | 2008 |
Retinal ganglion cell neuroprotection in a rat model of glaucoma following brimonidine, latanoprost or combined treatments.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Cell Survival; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Intraocular Pressure; Latanoprost; Neuroprotective Agents; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 2008 |
Noradrenergic and GABA B receptor activation differentially modulate inputs to the premotor nucleus RA in zebra finches.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Age Factors; Animals; Baclofen; Bicuculline; Brimonidine Tartrate; Electric Stimulation; Excitatory Postsynaptic Potentials; Finches; GABA Agonists; GABA Antagonists; In Vitro Techniques; Male; Models, Neurological; Neural Pathways; Neurons; Norepinephrine; Quinoxalines; Receptors, Adrenergic; Receptors, GABA-B; Telencephalon; Yohimbine | 2008 |
Letter to the editor regarding Gerente, V.M., Biondi, A.C., Barbosa, C.P., et al. Effect of brimonidine tartrate 0.15% on scotopic pupil: controlled trial. J. Ocul. Pharmacol. Ther 23:476-480, 2007.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Dark Adaptation; Humans; Quinoxalines; Reflex, Pupillary; Research Design | 2008 |
Oxidative stress plays a permissive role in alpha2-adrenoceptor-mediated events in immortalized SHR proximal tubular epithelial cells.
Topics: Acetophenones; Actins; Animals; Brimonidine Tartrate; Bucladesine; Cell Line, Transformed; Chloride-Bicarbonate Antiporters; Colforsin; Epithelial Cells; Hydrogen Peroxide; Kidney Tubules, Proximal; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidases; Oxidative Stress; Pertussis Toxin; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2 | 2008 |
Partial agonism at the human alpha(2A)-autoreceptor: role of binding duration.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adult; Aged; Autoreceptors; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Female; Guanfacine; Humans; In Vitro Techniques; Infant; Male; Middle Aged; Neocortex; Protein Binding; Quinoxalines; Receptors, Adrenergic, alpha-2; Temperature; Time Factors; Young Adult | 2008 |
Efficacy of brimonidine tartrate 0.2% ophthalmic solution in reducing halos after laser in situ keratomileusis.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Female; Humans; Keratomileusis, Laser In Situ; Lasers, Excimer; Light; Male; Night Blindness; Ophthalmic Solutions; Postoperative Complications; Postoperative Period; Pupil; Quinoxalines; Treatment Outcome | 2008 |
Alpha2 adrenergic modulation of NMDA receptor function as a major mechanism of RGC protection in experimental glaucoma and retinal excitotoxicity.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Signaling; Disease Models, Animal; Excitatory Amino Acid Agonists; Glaucoma; Male; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Quinoxalines; Rabbits; Rats; Rats, Inbred BN; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Ganglion Cells; Rolipram | 2008 |
Effects of advanced glycation end products-inductor glyoxal and hydrogen peroxide as oxidative stress factors on rat retinal organ cultures and neuroprotection by UK-14,304.
Topics: Animals; Brimonidine Tartrate; Female; Glycation End Products, Advanced; Glyoxal; Hydrogen Peroxide; Male; Neuroprotective Agents; Organ Culture Techniques; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Retina; Signal Transduction | 2008 |
Adrenergic regulation of cAMP/protein kinase A pathway in corneal epithelium and endothelium.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blotting, Western; Brimonidine Tartrate; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Endothelium, Corneal; Epithelium, Corneal; Immunoenzyme Techniques; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta | 2008 |
Effect of brimonidine tartrate 0.15% on night-vision difficulty and contrast testing after refractive surgery.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Contrast Sensitivity; Humans; Keratomileusis, Laser In Situ; Lasers, Excimer; Male; Middle Aged; Military Personnel; Night Blindness; Ophthalmic Solutions; Photorefractive Keratectomy; Postoperative Complications; Prospective Studies; Pupil; Quinoxalines; Surveys and Questionnaires; Visual Acuity | 2008 |
[Brimonidine intoxication in paediatrics. A presentation as intracranial hypertension syndrome].
Topics: Antihypertensive Agents; Brimonidine Tartrate; Humans; Infant; Intracranial Hypertension; Male; Quinoxalines; Syndrome | 2008 |
Effect of brimonidine on retinal ganglion cell survival in an optic nerve crush model.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cell Count; Cell Survival; Disease Models, Animal; Injections, Intraperitoneal; Nerve Crush; Neuroprotective Agents; Optic Nerve Injuries; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 2009 |
Aceclidine, brimonidine tartrate, and dapiprazole: comparison of miotic effect and tolerability under different lighting conditions.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Brimonidine Tartrate; Female; Humans; Light; Male; Middle Aged; Parasympatholytics; Piperazines; Prospective Studies; Pupil; Quinoxalines; Quinuclidines; Surveys and Questionnaires; Triazoles | 2009 |
A rapid and sensitive LC/MS/MS assay for the quantitation of brimonidine in ocular fluids and tissues.
Topics: Adrenergic alpha-Agonists; Animals; Aqueous Humor; Brimonidine Tartrate; Chromatography, Liquid; Ciliary Body; Drug Stability; Eye; Iris; Linear Models; Quinoxalines; Rabbits; Reference Standards; Reproducibility of Results; Retina; Sensitivity and Specificity; Tandem Mass Spectrometry; Vitreous Body | 2009 |
Brimonidine tartrate poisoning in children: frequency, trends, and use of naloxone as an antidote.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Child, Preschool; Humans; Infant; Naloxone; Poisoning; Quinoxalines; Retrospective Studies | 2009 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Microdialysis; Neurons; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2009 |
Pediatric systemic poisoning resulting from brimonidine ophthalmic drops.
Topics: Adrenergic alpha-Agonists; Bradycardia; Brimonidine Tartrate; Humans; Infant; Intracranial Hypertension; Male; Ophthalmic Solutions; Quinoxalines | 2009 |
Alpha-1-adrenergic receptor agonist activity of clinical alpha-adrenergic receptor agonists interferes with alpha-2-mediated analgesia.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Brimonidine Tartrate; Calcium; Clonidine; Dinoprostone; Drug Interactions; Excitatory Amino Acid Agonists; Exploratory Behavior; Hyperalgesia; Injections, Spinal; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain Measurement; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2 | 2009 |
Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Colitis; Colon; Cytokines; Dextran Sulfate; Dopamine beta-Hydroxylase; Idazoxan; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Models, Animal; Quinoxalines; Tyrosine 3-Monooxygenase | 2009 |
Treatment of patients with primary open-angle glaucoma with a fixed combination of brimonidine 0.2%/timolol 0.5%: multicenter, open-label, observational study in Germany.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Brimonidine Tartrate; Drug Therapy, Combination; Female; Germany; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Middle Aged; Quinoxalines; Timolol; Visual Fields; Young Adult | 2009 |
Temporal evolution of intraocular pressure elevation after pupillary dilation in pigment dispersion syndrome.
Topics: Adult; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Exfoliation Syndrome; Humans; Intraocular Pressure; Male; Middle Aged; Mydriatics; Ocular Hypertension; Phenylephrine; Pupil; Quinoxalines; Retrospective Studies; Tonometry, Ocular; Tropicamide | 2009 |
Analysis of alpha2-adrenergic receptors and effect of brimonidine on matrix metalloproteinases and their inhibitors in human ciliary body.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Blotting, Western; Brimonidine Tartrate; Cells, Cultured; Ciliary Body; Fluorescent Antibody Technique, Indirect; Humans; Matrix Metalloproteinases; Middle Aged; Muscle, Smooth; Quinoxalines; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinases; Transcriptional Activation | 2009 |
Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Newborn; Biophysics; Brimonidine Tartrate; Calcium; Calcium Signaling; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glycine; In Vitro Techniques; Long-Term Synaptic Depression; Neural Pathways; Neuronal Plasticity; Norepinephrine; Patch-Clamp Techniques; Phosphinic Acids; Piperidines; Propanolamines; Purinergic P1 Receptor Antagonists; Purkinje Cells; Pyrazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Synapses; Xanthines | 2009 |
A medical device/drug delivery system for treatment of glaucoma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Brimonidine Tartrate; Chromatography, High Pressure Liquid; Contact Lenses; Drug Delivery Systems; Female; Glaucoma; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Intraocular Pressure; Male; Middle Aged; Quinoxalines; Timolol | 2009 |
Comparative pharmacology of adrenergic alpha(2C) receptors coupled to Ca(2+) signaling through different Galpha proteins.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Signaling; CHO Cells; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Fluorometry; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Humans; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Recombinant Proteins; RNA, Messenger; Transfection | 2009 |
Costs and persistence of brimonidine versus brinzolamide in everyday glaucoma care: an analysis conducted on the UK General Practitioner Research Database.
Topics: Adrenergic alpha-Agonists; Aged; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Comorbidity; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Glaucoma, Open-Angle; Humans; Insurance Claim Review; Male; Quinoxalines; Sulfonamides; Thiazines; Time Factors | 2008 |
Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Biophysics; Brain; Brimonidine Tartrate; Buprenorphine; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Methionine; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Transgenic; Naltrexone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Yohimbine | 2009 |
Differential involvement of alpha1-adrenoceptors in vasoconstrictor responses to cooling in mouse plantar arteries in vitro and in vivo.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Brimonidine Tartrate; Cold Temperature; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle, Smooth, Vascular; Phentolamine; Phenylephrine; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-1; Regional Blood Flow; Skin; Tetrodotoxin; Vasoconstriction | 2009 |
Bilateral granulomatous uveitis as a side effect of topical brimonidine: two case reports.
Topics: Administration, Topical; Aged; Aged, 80 and over; Brimonidine Tartrate; Female; Glaucoma; Granuloma; Humans; Ophthalmic Solutions; Quinoxalines; Uveitis | 2009 |
Matrix metalloproteinase-9 expression in retinal ganglion cell layer and effect of topically applied brimonidine tartrate 0.2% therapy on this expression in an endothelin-1-induced optic nerve ischemia model.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Gene Expression Regulation, Enzymologic; In Situ Nick-End Labeling; Infusion Pumps; Intraocular Pressure; Matrix Metalloproteinase 9; Optic Neuropathy, Ischemic; Quinoxalines; Rabbits; Retinal Ganglion Cells | 2010 |
Increased risk for flap dislocation with perioperative brimonidine use in femtosecond laser in situ keratomileusis.
Topics: Adrenergic alpha-Agonists; Adult; Brimonidine Tartrate; Conjunctival Diseases; Corneal Stroma; Eye Hemorrhage; Female; Humans; Keratomileusis, Laser In Situ; Lasers, Excimer; Male; Myopia; Postoperative Complications; Prospective Studies; Quinoxalines; Risk Factors; Surgical Flaps; Surgical Wound Dehiscence; Visual Acuity; Young Adult | 2009 |
Aerobic exercise and intraocular pressure in normotensive and glaucoma patients.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Exercise; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Prostaglandins F, Synthetic; Quinoxalines; Timolol | 2009 |
Inhibition of vitreoretinal VEGF elevation and blood-retinal barrier breakdown in streptozotocin-induced diabetic rats by brimonidine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Glucose; Blood-Retinal Barrier; Blotting, Western; Brimonidine Tartrate; Capillary Permeability; Diabetes Mellitus, Experimental; Glutamic Acid; Infusion Pumps; Male; Quinoxalines; Rats; Rats, Inbred BN; Rats, Long-Evans; Retina; Vascular Endothelial Growth Factor A; Vitreous Body | 2010 |
Effectiveness of daily use of brimonidine as antimydriatic agent.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Humans; Light; Parasympatholytics; Piperazines; Pupil; Quinoxalines; Quinuclidines; Surveys and Questionnaires; Treatment Outcome; Triazoles | 2009 |
Possible neuroprotective effect of brimonidine in a mouse model of ischaemic optic neuropathy.
Topics: Animals; Brimonidine Tartrate; Disease Models, Animal; Eye Proteins; Fluorescent Antibody Technique, Indirect; Gene Expression; Glutathione Peroxidase; Glutathione Peroxidase GPX1; Heme Oxygenase-1; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Neuroprotective Agents; Nitric Oxide Synthase Type III; Optic Neuropathy, Ischemic; Oxidative Stress; Quinoxalines; Receptor Protein-Tyrosine Kinases; Receptor, TIE-2; Retinal Ganglion Cells; Retinal Neovascularization; Serpins; Superoxide Dismutase; Superoxide Dismutase-1; Vascular Endothelial Growth Factor A | 2009 |
Functional role of alpha2-adrenoceptor subtypes in the cooling-enhanced vasoconstriction of isolated cutaneous digital veins of the horse.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Cold Temperature; Horses; Protein Subunits; Quinoxalines; Receptors, Adrenergic, alpha-2; Skin; Substrate Specificity; Vasoconstriction; Veins | 2010 |
The effects of combination glaucoma medications on ocular surface epithelial cells.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Conjunctiva; Cornea; Drug Combinations; Epithelial Cells; Humans; In Vitro Techniques; Ophthalmic Solutions; Quinoxalines; Sodium Chloride; Sulfonamides; Thiophenes; Timolol | 2009 |
Retinal oxidative stress induced by intraocular hypertension in rats may be ameliorated by brimonidine treatment and N-acetyl cysteine supplementation.
Topics: Acetylcysteine; Animals; Brimonidine Tartrate; Catalase; Disease Models, Animal; Drug Therapy, Combination; Glutathione Peroxidase; Hyaluronic Acid; Intraocular Pressure; Male; Malondialdehyde; Nitric Oxide; Ocular Hypertension; Oxidative Stress; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Diseases; Tonometry, Ocular | 2009 |
Combination brimonidine and timolol.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Aged; Brimonidine Tartrate; Drug Combinations; Drug Hypersensitivity; Humans; Male; Necrosis; Quinoxalines; Raynaud Disease; Skin; Timolol | 2010 |
Lack of effect of the alpha2C-adrenoceptor Del322-325 polymorphism on inhibition of cyclic AMP production in HEK293 cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Binding, Competitive; Brimonidine Tartrate; Cell Line; Clonidine; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Humans; Linear Models; Norepinephrine; Polymorphism, Genetic; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Signal Transduction; Transfection | 2010 |
Early flap dislocation with perioperative brimonidine use in laser in situ keratomileusis.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Conjunctival Diseases; Corneal Stroma; Eye Hemorrhage; Humans; Keratomileusis, Laser In Situ; Lasers, Excimer; Myopia; Postoperative Complications; Quinoxalines; Risk Factors; Surgical Flaps; Surgical Wound Dehiscence; Visual Acuity | 2010 |
Noradrenergic lesion of the locus coeruleus increases the firing activity of the medial prefrontal cortex pyramidal neurons and the role of alpha2-adrenoceptors in normal and medial forebrain bundle lesioned rats.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Locus Coeruleus; Male; Medial Forebrain Bundle; Neurotoxins; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Yohimbine | 2010 |
Brimonidine is neuroprotective against glutamate-induced neurotoxicity, oxidative stress, and hypoxia in purified rat retinal ganglion cells.
Topics: Animals; Brimonidine Tartrate; Cell Hypoxia; Cell Separation; Cell Survival; Glutamic Acid; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Quinoxalines; Rats; Rats, Wistar; Retinal Ganglion Cells | 2010 |
Microbial keratitis secondary to infection with Citrobacter koseri.
Topics: Aged; Anti-Bacterial Agents; Brimonidine Tartrate; Cefazolin; Citrobacter koseri; Corneal Ulcer; Drug Therapy, Combination; Enterobacteriaceae Infections; Eye Infections, Bacterial; Gentamicins; Humans; Male; Microbial Sensitivity Tests; Quinoxalines; Timolol | 2010 |
Reaction of Müller cells in an experimental rat model of increased intraocular pressure following timolol, latanoprost and brimonidine.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Disease Models, Animal; Glaucoma; Glial Fibrillary Acidic Protein; Gliosis; Intraocular Pressure; Latanoprost; Male; Neuroglia; Prostaglandins F, Synthetic; Quinoxalines; Rats; Rats, Wistar; Retina; Timolol; Tonometry, Ocular | 2010 |
Nimodipine enhancement of alpha2 adrenergic modulation of NMDA receptor via a mechanism independent of Ca2+ channel blocking.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Blockers; Excitatory Amino Acid Agonists; Injections; Male; Microscopy, Confocal; N-Methylaspartate; Nimodipine; Patch-Clamp Techniques; Quinoxalines; Rabbits; Rats; Rats, Inbred BN; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Retinal Diseases; Retinal Ganglion Cells; Vitreous Body | 2010 |
Short-term effect of topical brimonidine tartrate on intrastromal corneal pressure in rabbits.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Corneal Stroma; Intraocular Pressure; Male; Quinoxalines; Rabbits; Tonometry, Ocular | 2010 |
Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Amides; Animals; Antioxidants; Benzophenanthridines; Body Temperature Regulation; Brimonidine Tartrate; Cold Temperature; Cyclic N-Oxides; Cytoskeletal Proteins; Female; Horses; Protein Kinase C; Protein Kinase Inhibitors; Pyridines; Quinoxalines; Reactive Oxygen Species; rho-Associated Kinases; Rotenone; Spin Labels; Vasoconstriction; Vasodilator Agents; Veins | 2010 |
Use of rituximab for periocular and intraocular mucosa-associated lymphoid tissue lymphoma.
Topics: Androstadienes; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Brimonidine Tartrate; Drug Therapy, Combination; Eye Neoplasms; Female; Glaucoma; Humans; Latanoprost; Loteprednol Etabonate; Lymphoma, B-Cell, Marginal Zone; Middle Aged; Parotid Neoplasms; Prostaglandins F, Synthetic; Quinoxalines; Rituximab; Sulfonamides; Thiophenes; Timolol | 2010 |
Pseudopheochromocytoma secondary to brimonidine ophthalmic solution.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Diagnosis, Differential; Female; Humans; Hypertension; Pheochromocytoma; Quinoxalines | 2010 |
The effect of brimonidine on transepithelial resistance in a human retinal pigment epithelial cell line.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Cell Hypoxia; Cell Line; Electric Impedance; Humans; Quinoxalines; Receptors, Adrenergic, alpha-2; Retinal Pigment Epithelium | 2010 |
Alpha2-adrenergic receptors and their core involvement in the process of axonal growth in retinal explants.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Autoradiography; Axons; Brimonidine Tartrate; Clonidine; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Fluorescent Antibody Technique, Indirect; Glaucoma; Glial Fibrillary Acidic Protein; Optic Nerve Injuries; Organ Culture Techniques; Platelet Activating Factor; Protein Disulfide-Isomerases; Proteomics; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Laminin; Retina; Retinal Degeneration; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
Brimonidine and eye pressure.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Humans; Intraocular Pressure; Low Tension Glaucoma; Quinoxalines | 2010 |
Brimonidine hypersensitivity when switching between 0.2% and 0.15% formulations.
Topics: Administration, Topical; Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Hypersensitivity; Eye; Female; Glaucoma; Humans; Intraocular Pressure; Male; Middle Aged; Ophthalmic Solutions; Quinoxalines; Treatment Outcome | 2010 |
Optical fiber-coupled ocular spectrometer for measurement of drug concentration in the anterior eye--applications in pharmaceuticals research.
Topics: Administration, Topical; Animals; Anterior Eye Segment; Brimonidine Tartrate; Equipment Design; Humans; Ophthalmic Solutions; Optical Fibers; Quinoxalines; Rabbits; Spectrum Analysis; Technology, Pharmaceutical | 2010 |
Diurnal and nocturnal effects of brimonidine monotherapy on intraocular pressure.
Topics: Adrenergic alpha-Agonists; Aged; Antihypertensive Agents; Blood Pressure; Brimonidine Tartrate; Circadian Rhythm; Female; Glaucoma, Open-Angle; Heart Rate; Humans; Intraocular Pressure; Male; Middle Aged; Ocular Hypertension; Prospective Studies; Quinoxalines | 2010 |
Regional heterogeneity of α-adrenoreceptor subtypes in arteriolar networks of mouse skeletal muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Arterioles; Brimonidine Tartrate; Isoproterenol; Male; Mice; Mice, Inbred C57BL; Models, Animal; Muscle, Skeletal; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2010 |
Dexmedetomidine induces both relaxations and contractions, via different {alpha}2-adrenoceptor subtypes, in the isolated mesenteric artery and aorta of the rat.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Aorta; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Endothelium, Vascular; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Models, Biological; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Naphthalenes; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Prazosin; Propionates; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Thromboxane | 2010 |
Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion.
Topics: Animals; Antihypertensive Agents; Aqueous Humor; Betaxolol; Brimonidine Tartrate; Coloring Agents; Dextrans; Fluorescein-5-isothiocyanate; Intraocular Pressure; Latanoprost; Male; Manometry; Mice; Mice, Inbred BALB C; Prostaglandins F, Synthetic; Quinoxalines; Sclera; Tonometry, Ocular; Trabecular Meshwork; Uvea; Venous Pressure | 2011 |
Postjunctional α2C-adrenoceptors mediate vasoconstriction in rat tail artery: influence of precontraction and temperature on vasoreactivity.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Brimonidine Tartrate; Dioxanes; Imidazoles; In Vitro Techniques; Isoindoles; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Piperazines; Prazosin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Serotonin; Tail; Temperature; Vasoconstriction; Yohimbine | 2010 |
α₂-Adrenoceptor functionality in postmortem frontal cortex of depressed suicide victims.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic alpha-2 Receptor Agonists; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Brimonidine Tartrate; Depressive Disorder, Major; Female; Frontal Lobe; GTP-Binding Proteins; Humans; Male; Middle Aged; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Signal Transduction; Suicide | 2010 |
Effects of brimonidine 0.2%-timolol 0.5% fixed-combination therapy for glaucoma.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Drug Combinations; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Low Tension Glaucoma; Male; Middle Aged; Prospective Studies; Pupil; Quinoxalines; Timolol; Tonometry, Ocular; Treatment Outcome | 2010 |
The clinical impact of 2 different strategies for initiating therapy in patients with ocular hypertension.
Topics: Adult; Antihypertensive Agents; Blindness; Brimonidine Tartrate; Decision Trees; Disease Progression; Drug Therapy, Combination; Female; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Markov Chains; Middle Aged; Models, Biological; Monte Carlo Method; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Risk Assessment; Sulfonamides; Thiophenes; Timolol | 2011 |
Persistence of glaucoma medical therapy in the Glasgow Glaucoma Database.
Topics: Algorithms; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Clinical Protocols; Databases, Factual; Drug Utilization; Female; Glaucoma; Humans; Male; Ocular Hypertension; Quinoxalines; Scotland; Timolol | 2011 |
Ocular perforation by an acupuncture needle.
Topics: Acupuncture Therapy; Aged; Antihypertensive Agents; Brimonidine Tartrate; Combined Modality Therapy; Eye Injuries, Penetrating; Glaucoma; Humans; Laser Coagulation; Male; Needles; Needlestick Injuries; Quinoxalines; Retina; Retinal Perforations; Timolol; Visual Acuity; Vitrectomy; Vitreous Hemorrhage | 2011 |
Effect of brimonidine tartrate 0.10% ophthalmic solution on pupil diameter.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Antihypertensive Agents; Brimonidine Tartrate; Dark Adaptation; Diagnostic Techniques, Ophthalmological; Eye Color; Female; Humans; Light; Male; Middle Aged; Ophthalmic Solutions; Pupil; Quinoxalines; Young Adult | 2011 |
Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Choroidal Neovascularization; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Fluorescein Angiography; Humans; Immunoblotting; Infant, Newborn; Intravitreal Injections; Laser Coagulation; Male; Mice; Mice, Inbred C57BL; Oxygen; Quinoxalines; Rabbits; Rats; Rats, Inbred BN; Retinal Neovascularization; Retinopathy of Prematurity; Time Factors | 2011 |
A case of essential iris atrophy in a male patient.
Topics: Acetazolamide; Adult; Brimonidine Tartrate; Humans; Iridocorneal Endothelial Syndrome; Male; Quinoxalines; Timolol; Treatment Refusal; Visual Acuity | 2010 |
An immunohistochemical analysis of the neuroprotective effects of memantine, hyperbaric oxygen therapy, and brimonidine after acute ischemia reperfusion injury.
Topics: Animals; Brimonidine Tartrate; Cell Count; Disease Models, Animal; Hyperbaric Oxygenation; Immunohistochemistry; Injections, Intravenous; Memantine; Neuroprotective Agents; Ophthalmic Solutions; Quinoxalines; Rats; Rats, Wistar; Reperfusion Injury; Retina; Retinal Ganglion Cells | 2011 |
Effect of brimonidine on retinal blood flow autoregulation in primary open-angle glaucoma.
Topics: Aged; Antihypertensive Agents; Blood Flow Velocity; Brimonidine Tartrate; Female; Glaucoma, Open-Angle; Hemodynamics; Humans; Laser-Doppler Flowmetry; Male; Middle Aged; Posture; Quinoxalines; Regional Blood Flow; Retinal Artery; Retrospective Studies; Statistics, Nonparametric | 2011 |
Prevention of retinal ganglion cell swelling by systemic brimonidine in a rat experimental glaucoma model.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Cell Count; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Glaucoma, Open-Angle; Injections, Intraperitoneal; Intraocular Pressure; Papilledema; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Treatment Outcome | 2011 |
Nanovesicular formulation of brimonidine tartrate for the management of glaucoma: in vitro and in vivo evaluation.
Topics: Animals; Brimonidine Tartrate; Chemistry, Pharmaceutical; Cornea; Disease Management; Drug Carriers; Glaucoma; Nanoparticles; Quinoxalines; Rabbits | 2011 |
Asymmetry of 24-hour intraocular pressure reduction by topical ocular hypotensive medications in fellow eyes.
Topics: Administration, Topical; Adult; Aged; Antihypertensive Agents; Brimonidine Tartrate; Circadian Rhythm; Cloprostenol; Female; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Latanoprost; Male; Middle Aged; Ocular Hypertension; Posture; Prostaglandins F, Synthetic; Quinoxalines; Retrospective Studies; Sulfonamides; Thiazines; Timolol; Tonometry, Ocular; Travoprost | 2011 |
Effects of brimonidine timolol fixed combination therapy on anterior ocular segment configuration.
Topics: Adult; Anterior Eye Segment; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Female; Glaucoma, Open-Angle; Gonioscopy; Humans; Intraocular Pressure; Male; Ophthalmic Solutions; Pilocarpine; Pupil; Quinoxalines; Timolol; Tonometry, Ocular | 2011 |
Activation of extracellular-signal regulated kinase by platelet-derived growth factor is potentiated by phenylephrine in primary cultures of adult rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blotting, Western; Brimonidine Tartrate; Cells, Cultured; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Male; Metaproterenol; Phenylephrine; Phosphorylation; Platelet-Derived Growth Factor; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tetradecanoylphorbol Acetate; TOR Serine-Threonine Kinases | 2011 |
α(2) Adrenergic and imidazoline receptor agonists prevent cue-induced cocaine seeking.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cocaine; Cues; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Extinction, Psychological; Guanfacine; Imidazoles; Imidazoline Receptors; Isoquinolines; Male; Motor Activity; Naphthyridines; Prazosin; Propranolol; Pyrimidines; Pyrroles; Quinoxalines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration | 2011 |
Brimonidine tartrate-eudragit long-acting nanoparticles: formulation, optimization, in vitro and in vivo evaluation.
Topics: Acrylic Resins; Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Stability; Glaucoma; Hydrogen-Ion Concentration; Intraocular Pressure; Kinetics; Nanoparticles; Nanotechnology; Quinoxalines; Rabbits; Solubility; Technology, Pharmaceutical | 2011 |
[Pupillary block acute glaucoma due to acrylic intraocular lens posterior dislocation after Nd:YAG capsulotomy].
Topics: Acute Disease; Aged; Brimonidine Tartrate; Combined Modality Therapy; Dipyrone; Drug Therapy, Combination; Emergencies; Female; Furosemide; Glaucoma; Hernia; Humans; Iris; Laser Therapy; Lasers, Solid-State; Lens Capsule, Crystalline; Lens Subluxation; Lenses, Intraocular; Mannitol; Metoclopramide; Postoperative Complications; Pseudophakia; Pupil Disorders; Quinoxalines; Timolol; Vitrectomy; Vitreous Body | 2011 |
Chitosan nanoparticles for controlled delivery of brimonidine tartrate to the ocular membrane.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Calorimetry, Differential Scanning; Chitosan; Delayed-Action Preparations; Drug Compounding; Drug Delivery Systems; Electrochemistry; Excipients; Eye; Freeze Drying; Intraocular Pressure; Irritants; Membranes; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanoparticles; Ophthalmic Solutions; Particle Size; Quinoxalines; Rabbits; Solubility; Spectroscopy, Fourier Transform Infrared | 2011 |
Polyamidoamine dendrimer hydrogel for enhanced delivery of antiglaucoma drugs.
Topics: Animals; Brimonidine Tartrate; Cattle; Cell Line; Dendrimers; Drug Combinations; Drug Delivery Systems; Epithelium, Corneal; Glaucoma; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Ophthalmic Solutions; Quinoxalines; Timolol | 2012 |
Activation of extracellular-signal regulated kinase by epidermal growth factor is potentiated by cAMP-elevating agents in primary cultures of adult rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Animals; Brimonidine Tartrate; Cell Culture Techniques; Cell Proliferation; Cyclic AMP; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Male; MAP Kinase Kinase 2; Metaproterenol; Mitogen-Activated Protein Kinase 3; Molecular Targeted Therapy; Phosphorylation; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2011 |
Biodegradable ocular inserts for sustained delivery of brimonidine tartarate: preparation and in vitro/in vivo evaluation.
Topics: Absorbable Implants; Acrylic Resins; Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Alginates; Animals; Brimonidine Tartrate; Calorimetry, Differential Scanning; Cellulose; Chemistry, Pharmaceutical; Chitosan; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Glaucoma; Glucuronic Acid; Hexuronic Acids; Hydrophobic and Hydrophilic Interactions; Hypromellose Derivatives; Intraocular Pressure; Kinetics; Methylcellulose; Ophthalmic Solutions; Polymers; Polymethacrylic Acids; Polyvinyls; Povidone; Quinoxalines; Rabbits; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; X-Ray Diffraction | 2011 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord | 2012 |
[Effect of brimonidine on central corneal thickness].
Topics: Adrenergic alpha-2 Receptor Agonists; Antihypertensive Agents; Brimonidine Tartrate; Cornea; Female; Humans; Intraocular Pressure; Male; Organ Size; Quinoxalines; Young Adult | 2012 |
Sustained ocular delivery of brimonidine tartrate using ion activated in situ gelling system.
Topics: Animals; Biological Availability; Brimonidine Tartrate; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Delivery Systems; Drug Stability; Eye; Gels; Glaucoma; Hydrogen-Ion Concentration; Ions; Ophthalmic Solutions; Polysaccharides, Bacterial; Quinoxalines; Rabbits | 2012 |
The long-term outcomes of four alternative treatment strategies for primary open-angle glaucoma.
Topics: Administration, Topical; Antihypertensive Agents; Brimonidine Tartrate; Cost-Benefit Analysis; Decision Support Techniques; Disease Progression; Drug Costs; Economics, Pharmaceutical; Follow-Up Studies; Glaucoma, Open-Angle; Health Care Costs; Humans; Intraocular Pressure; Latanoprost; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quality-Adjusted Life Years; Quinoxalines; Sulfonamides; Thiophenes; Timolol; Treatment Outcome | 2012 |
Alpha2C-adrenoceptors play a prominent role in sympathetic constriction of porcine pulmonary arteries.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium; Calcium Channel Agonists; Enzyme Inhibitors; HeLa Cells; Humans; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Pulmonary Artery; Pulmonary Veins; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-2; Swine; Vasoconstriction | 2012 |
Strabismus surgery hemostasis.
Topics: Adolescent; Adrenergic alpha-2 Receptor Agonists; Blood Loss, Surgical; Brimonidine Tartrate; Case-Control Studies; Female; Hemostasis, Surgical; Humans; Male; Oculomotor Muscles; Ophthalmic Solutions; Ophthalmologic Surgical Procedures; Phenylephrine; Postoperative Hemorrhage; Prospective Studies; Quinoxalines; Strabismus; Treatment Outcome; Vasoconstrictor Agents | 2012 |
Characterization of α(2B)-adrenoceptor ligand binding in the presence of muscarinic toxin α and delineation of structural features of receptor binding selectivity.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Allosteric Site; Animals; Brimonidine Tartrate; Calcium Signaling; Cell Line; Elapid Venoms; Humans; Ligands; Mutant Chimeric Proteins; Neurotoxins; Peptides; Protein Interaction Domains and Motifs; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Reptilian Proteins; Signal Transduction; Spodoptera | 2012 |
Presynaptic inhibition of glutamate transmission by α2 receptors in the VTA.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brimonidine Tartrate; Clonidine; Dopaminergic Neurons; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acids; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Mice; Neural Inhibition; Patch-Clamp Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium Channel Blockers; Tetrodotoxin; Ventral Tegmental Area | 2012 |
Microbead-induced ocular hypertensive mouse model for screening and testing of aqueous production suppressants for glaucoma.
Topics: Animals; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Disease Models, Animal; Drug Evaluation, Preclinical; Feasibility Studies; Intraocular Pressure; Latanoprost; Mice; Mice, Inbred C57BL; Microspheres; Muscarinic Agonists; Ocular Hypertension; Optic Nerve; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Retinal Ganglion Cells; Sulfonamides; Thiazines; Timolol; Tomography, Optical Coherence | 2012 |
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Idazoxan; Male; Methoxamine; Movement; Neurons; Norepinephrine; Nucleus Accumbens; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2012 |
Combining the isoabsorptive point in the ratio spectrum and the smart ratio difference methods for a single step determination of compounds with overlapped spectra.
Topics: Absorption; Brimonidine Tartrate; Brimonidine Tartrate, Timolol Maleate Drug Combination; Drug Combinations; Ophthalmic Solutions; Quinoxalines; Reference Standards; Reproducibility of Results; Spectrophotometry; Timolol | 2012 |
Evaluation of extended release brimonidine intravitreal device in normotensive rabbit eyes.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Dark Adaptation; Drug Carriers; Drug Evaluation, Preclinical; Drug Implants; Electroretinography; Male; Polyesters; Quinoxalines; Rabbits; Retina; Vitreous Body | 2012 |
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Brimonidine Tartrate; Calcium; Cells, Cultured; Diabetes Mellitus, Type 2; Diazoxide; Female; Hyperglycemia; Imidazoles; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Quinoxalines; Yohimbine | 2012 |
Biomechanical profile of the cornea in primary congenital glaucoma.
Topics: Adolescent; Antihypertensive Agents; Biomechanical Phenomena; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Cell Count; Cornea; Corneal Keratocytes; Endothelium, Corneal; Female; Humans; Hydrophthalmos; Male; Microscopy, Confocal; Prospective Studies; Quinoxalines | 2013 |
Comparison of the progression rates of the superior, inferior, and both hemifield defects in normal-tension glaucoma patients.
Topics: Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Cohort Studies; Disease Progression; Female; Humans; Intraocular Pressure; Latanoprost; Low Tension Glaucoma; Male; Middle Aged; Nerve Fibers; Prostaglandins F, Synthetic; Quinoxalines; Retinal Ganglion Cells; Retrospective Studies; Tonometry, Ocular; Vision Disorders; Visual Field Tests; Visual Fields | 2012 |
The activity of lowering intraocular pressure of cassiae seed extract in a DBA/2J mouse glaucoma model.
Topics: Acetazolamide; Animals; Antihypertensive Agents; Aqueous Humor; Brimonidine Tartrate; Cassia; Chromatography, High Pressure Liquid; Disease Models, Animal; Glaucoma; Glycosides; Intraocular Pressure; L-Lactate Dehydrogenase; Male; Mice; Mice, Inbred DBA; Plant Extracts; Polyphenols; Quinoxalines; Seeds | 2013 |
Brimonidine blocks glutamate excitotoxicity-induced oxidative stress and preserves mitochondrial transcription factor a in ischemic retinal injury.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; bcl-2-Associated X Protein; bcl-Associated Death Protein; Brimonidine Tartrate; DNA-Binding Proteins; Glutamic Acid; Ischemia; Mitochondrial Proteins; Oxidative Phosphorylation; Oxidative Stress; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Diseases; Retinal Ganglion Cells; Superoxide Dismutase; Transcription Factors | 2012 |
[Pharmacological profile and clinical efficacy of brimonidine tartrate (AIPHAGAN(®) ophthalmic solution 0.1%)].
Topics: Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Clinical Trials as Topic; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Solutions; Quinoxalines | 2012 |
α2-adrenergic receptors in spiral ganglion neurons may mediate protective effects of brimonidine and yohimbine against glutamate and hydrogen peroxide toxicity.
Topics: Animals; Brimonidine Tartrate; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Glutamic Acid; Hydrogen Peroxide; Neuroprotective Agents; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Spiral Ganglion; Yohimbine | 2013 |
[Use of glaucoma medications during pregnancy and breastfeeding].
Topics: Abnormalities, Drug-Induced; Administration, Ophthalmic; Administration, Oral; Adrenergic beta-Antagonists; Animals; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Contraindications; Female; Fetus; Gels; Glaucoma; Humans; Hypotension; Intraocular Pressure; Lactation; Obstetric Labor, Premature; Ophthalmic Solutions; Pregnancy; Pregnancy Complications; Prostaglandins; Quinoxalines; Timolol | 2012 |
Rosacea: update on management and emerging therapies.
Topics: Administration, Cutaneous; Adrenergic Agents; Anti-Infective Agents; Antiparasitic Agents; Brimonidine Tartrate; Dermatologic Agents; Dicarboxylic Acids; Doxycycline; Female; Humans; Ivermectin; Male; Metronidazole; Oxymetazoline; Quality of Life; Quinoxalines; Randomized Controlled Trials as Topic; Rosacea; Sulfacetamide; Treatment Outcome | 2012 |
Brimonidine-timolol fixed combination induced granulomatous inflammation of the eye.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Conjunctivitis; Drug Therapy, Combination; Female; Glaucoma; Humans; Male; Middle Aged; Quinoxalines; Timolol; Uveitis | 2013 |
Contribution of α-adrenoceptor stimulation by phenylephrine to basal nitric oxide production in the isolated mouse aorta.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Aorta, Thoracic; Brimonidine Tartrate; Dose-Response Relationship, Drug; Imidazoles; Isoindoles; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Vasoconstrictor Agents; Yohimbine | 2013 |
Studying the effect of iris mechanics on the pupillary light reflex using brimonidine-induced anisocoria.
Topics: Adult; Anisocoria; Brimonidine Tartrate; Female; Humans; Iris; Light; Male; Ophthalmic Solutions; Quinoxalines; Reflex, Pupillary; Sympatholytics | 2013 |
Brimonidine allergy presenting as vernal-like keratoconjunctivitis.
Topics: Aged; Antihypertensive Agents; Brimonidine Tartrate; Conjunctivitis, Allergic; Diagnosis, Differential; Drug Hypersensitivity; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Male; Quinoxalines; Withholding Treatment | 2015 |
Translocation of activator of G-protein signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network.
Topics: Animals; Biomarkers; Brimonidine Tartrate; Cell Membrane; Chlorocebus aethiops; COS Cells; Endosomes; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gi-Go; Guanine Nucleotide Dissociation Inhibitors; HEK293 Cells; Humans; Lysosomes; Protein Structure, Tertiary; Protein Transport; Quinoxalines; Receptors, Cell Surface; Subcellular Fractions; Time Factors; trans-Golgi Network | 2013 |
Novel topical ophthalmic formulations for management of glaucoma.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Glaucoma; Lactic Acid; Mice; Nanoparticles; Ophthalmic Solutions; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinoxalines | 2013 |
Brimonidine protects against loss of Thy-1 promoter activation following optic nerve crush.
Topics: Adrenergic alpha-2 Receptor Agonists; Analysis of Variance; Animals; Brimonidine Tartrate; Cell Count; Disease Models, Animal; Female; Longitudinal Studies; Male; Mice; Microscopy, Fluorescence; Nerve Crush; Optic Nerve Injuries; Promoter Regions, Genetic; Protective Agents; Quinoxalines; Retinal Ganglion Cells; Thy-1 Antigens | 2013 |
Suspected granulomatous anterior uveitis associated with brimonidine tartrate 0.2% and timolol maleate 0.5% ophthalmic solution.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Brimonidine Tartrate; Drug Combinations; Female; Glaucoma, Open-Angle; Granuloma; Humans; Intraocular Pressure; Ophthalmic Solutions; Quinoxalines; Timolol; Uveitis, Anterior | 2013 |
Brinzolamide/brimonidine (Simbrinza) for glaucoma.
Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Carbonic Anhydrase Inhibitors; Drug Combinations; Glaucoma; Humans; Quinoxalines; Sulfonamides; Thiazines | 2013 |
Brimonidine promotes axon growth after optic nerve injury through Erk phosphorylation.
Topics: Animals; Axons; Brimonidine Tartrate; Gene Expression Regulation; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Optic Nerve; Optic Nerve Injuries; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Receptor, trkB; Receptors, Nerve Growth Factor; Regeneration | 2013 |
Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Anesthesia, Spinal; Animals; Brimonidine Tartrate; Clonidine; Drug Synergism; Enzyme Inhibitors; Female; Immunohistochemistry; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligopeptides; Protein Kinase C-epsilon; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Opioid, delta; Spinal Cord | 2013 |
[Charles Bonnet syndrome precipitated by brimonidine].
Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Aged, 80 and over; Brimonidine Tartrate; Exfoliation Syndrome; Female; Hallucinations; Humans; Macular Degeneration; Neurologic Examination; Occipital Lobe; Postoperative Complications; Quinoxalines; Sulfonamides; Thiazines; Trabeculectomy; Visual Acuity | 2013 |
The effects of impact vibration on peripheral blood vessels and nerves.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Male; Peripheral Nerves; Quinoxalines; Rats; Rats, Sprague-Dawley; Skin; Tail; Ubiquitin Thiolesterase; Vasoconstriction; Vasodilation; Vasodilator Agents; Vibration | 2013 |
In vitro characterization of a controlled-release ocular insert for delivery of brimonidine tartrate.
Topics: Animals; Brimonidine Tartrate; Cell Death; Delayed-Action Preparations; Drug Delivery Systems; Epithelial Cells; Eye; Humans; Lactic Acid; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Quinoxalines | 2014 |
Brimonidine gel (Mirvaso) for rosacea.
Topics: Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Drug Approval; Gels; Humans; Quinoxalines; Randomized Controlled Trials as Topic; Rosacea; Treatment Outcome; United States; United States Food and Drug Administration | 2013 |
Chick chorioallantoic membrane model for in ovo evaluation of timolol maleate-brimonidine tartrate ocular inserts.
Topics: Animals; Brimonidine Tartrate; Chick Embryo; Chorioallantoic Membrane; Drug Delivery Systems; Drug Evaluation, Preclinical; Ocular Absorption; Organ Culture Techniques; Quinoxalines; Timolol | 2014 |
Can ophthalmic drops cause central nervous system depression and cardiogenic shock in infants?
Topics: Absorption; Administration, Ophthalmic; Apnea; Bradycardia; Brimonidine Tartrate; Consciousness Disorders; Dose-Response Relationship, Drug; Drug Combinations; Emergencies; Female; Glaucoma; Humans; Hypothermia; Infant; Muscle Hypotonia; Nasal Mucosa; Ophthalmic Solutions; Quinoxalines; Shock, Cardiogenic; Sulfonamides; Thiazines; Timolol | 2013 |
Urrets- Zavalia Syndrome after glaucoma filtration device implantation.
Topics: Acetazolamide; Aged; Brimonidine Tartrate; Cataract Extraction; Combined Modality Therapy; Drug Resistance; Drug Therapy, Combination; Female; Glaucoma Drainage Implants; Glaucoma, Open-Angle; Humans; Hypertension; Miotics; Mydriasis; Ocular Hypertension; Pilocarpine; Prostaglandins F; Quinoxalines; Sulfonamides; Syndrome; Thiophenes; Timolol | 2013 |
Management of facial erythema of rosacea: what is the role of topical α-adrenergic receptor agonist therapy?
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Brimonidine Tartrate; Erythema; Humans; Oxymetazoline; Quinoxalines; Rosacea; Sympathetic Nervous System; Vasodilation | 2013 |
[Iris microhaemangiomas: presentation of a case].
Topics: Administration, Topical; Aged; Brimonidine Tartrate; Cyclopentolate; Dexamethasone; Diabetes Mellitus, Type 2; Female; Glaucoma, Open-Angle; Hamartoma; Humans; Hyphema; Iris Diseases; Latanoprost; Microscopy, Acoustic; Ophthalmic Solutions; Prostaglandins F, Synthetic; Quinoxalines; Vision Disorders | 2014 |
[Current trend of glaucoma medication with various eye drops].
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Antihypertensive Agents; Betaxolol; Brimonidine Tartrate; Glaucoma; Humans; Latanoprost; Neuroprotective Agents; Ophthalmic Solutions; Ophthalmology; Prostaglandins; Prostaglandins F, Synthetic; Quinoxalines; Sulfonamides; Thiophenes | 2013 |
Rebound erythema and burning sensation from a new topical brimonidine tartrate gel 0.33%.
Topics: Administration, Cutaneous; Adult; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Administration Schedule; Erythema; Female; Follow-Up Studies; Gels; Humans; Pain; Quinoxalines; Recurrence; Risk Assessment; Rosacea; Sampling Studies; Severity of Illness Index | 2014 |
Ocular pharmacokinetics of intravitreally administered brimonidine and dexamethasone in animal models with and without blood-retinal barrier breakdown.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Aqueous Humor; Biological Availability; Blood-Retinal Barrier; Brimonidine Tartrate; Capillary Permeability; Choroid; Choroidal Neovascularization; Chromatography, High Pressure Liquid; Dexamethasone; Female; Glucocorticoids; Intravitreal Injections; Macaca fascicularis; Models, Animal; Quinoxalines; Rabbits; Retina; Tandem Mass Spectrometry; Vitreous Body | 2014 |
[Protection effect of sodium hyaluronate on ocular surface toxicity induced by Benzalkonium chloride-preserved brimonidine in rabbits].
Topics: Animals; Benzalkonium Compounds; Brimonidine Tartrate; Conjunctiva; Cornea; Female; Hyaluronic Acid; Ophthalmic Solutions; Quinoxalines; Rabbits | 2013 |
Mechanism - based translational pharmacokinetic - pharmacodynamic model to predict intraocular pressure lowering effect of drugs in patients with glaucoma or ocular hypertension.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Female; Forecasting; Glaucoma; Humans; Intraocular Pressure; Latanoprost; Male; Models, Biological; Ocular Hypertension; Prostaglandins F, Synthetic; Quinoxalines; Rabbits; Translational Research, Biomedical; Treatment Outcome | 2014 |
72nd annual meeting of the American Academy of Dermatology.
Topics: Antifungal Agents; Attention Deficit Disorder with Hyperactivity; Boron Compounds; Botulinum Toxins, Type A; Bridged Bicyclo Compounds, Heterocyclic; Brimonidine Tartrate; Depression; Dermatitis, Atopic; Food Hypersensitivity; Humans; Immunologic Factors; Ivermectin; Phosphodiesterase Inhibitors; Phototherapy; Piperidines; Protein Kinase Inhibitors; Pyrimidines; Pyrroles; Quinoxalines; Skin Diseases; Societies, Medical; Thalidomide; Triazoles; United States | 2014 |
Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, part 5: a guide on the management of rosacea.
Topics: Administration, Cutaneous; Administration, Oral; Adrenergic alpha-2 Receptor Agonists; Anti-Infective Agents; Brimonidine Tartrate; Consensus; Dermatologic Agents; Dicarboxylic Acids; Doxycycline; Erythema; Humans; Metronidazole; Quinoxalines; Rosacea; Severity of Illness Index; Societies, Medical | 2014 |
Brimonidine effective but may lead to significant rebound erythema.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Brimonidine Tartrate; Erythema; Female; Humans; Quinoxalines; Rosacea; Vasoconstriction | 2014 |
Transactivation of EGF receptors in chicken Müller cells by α2A-adrenergic receptors stimulated by brimonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blotting, Western; Brimonidine Tartrate; Cells, Cultured; Chick Embryo; Ependymoglial Cells; ErbB Receptors; Glaucoma; Immunohistochemistry; MAP Kinase Signaling System; Quinoxalines; Real-Time Polymerase Chain Reaction; Receptors, Adrenergic, alpha-2; Retina; RNA; Transcriptional Activation | 2014 |
Vasoconstriction and anti-inflammatory properties of the selective α-adrenergic receptor agonist brimonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents; Biopsy; Brimonidine Tartrate; Disease Models, Animal; Female; Humans; Inflammation; Mice, Inbred BALB C; Quinoxalines; Receptors, Adrenergic, alpha-2; Skin; Tissue Culture Techniques; Vasoconstrictor Agents; Vasodilation | 2014 |
Dual effects of α2 -adrenoceptors in modulating myogenic tone in sheep isolated internal anal sphincter.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Anal Canal; Animals; Brimonidine Tartrate; Clonidine; Dexmedetomidine; Muscle Contraction; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Sheep; Tissue Culture Techniques | 2014 |
28-day intraocular pressure reduction with a single dose of brimonidine tartrate-loaded microspheres.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Brimonidine Tartrate; Drug Delivery Systems; Intraocular Pressure; Microspheres; Models, Animal; Quinoxalines; Rabbits | 2014 |
Optical coherence tomography imaging of erythematotelangiectatic rosacea during treatment with brimonidine topical gel 0.33%: a potential method for treatment outcome assessment.
Topics: Administration, Cutaneous; Adrenergic alpha-2 Receptor Agonists; Adult; Brimonidine Tartrate; Female; Gels; Humans; Quinoxalines; Rosacea; Severity of Illness Index; Tomography, Optical Coherence; Treatment Outcome | 2014 |
Brimonidine prevents neurodegeneration in a mouse model of normal tension glaucoma.
Topics: Animals; Brimonidine Tartrate; Excitatory Amino Acid Transporter 3; Female; Glaucoma; Humans; Male; Mice; Mice, Knockout; Protective Agents; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Retinal Degeneration; Retinal Ganglion Cells | 2014 |
Recovery of vascular function after exposure to a single bout of segmental vibration.
Topics: Acetylcholine; Animals; Arteries; Brimonidine Tartrate; Disease Models, Animal; Endothelium, Vascular; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vibration | 2014 |
New agents for the treatment of erythematotelangiectatic rosacea.
Topics: Brimonidine Tartrate; Clinical Trials as Topic; Dermatologic Agents; Gels; Humans; Oxymetazoline; Quinoxalines; Rosacea; Treatment Outcome | 2014 |
Prevention of neutrophil extravasation by α2-adrenoceptor-mediated endothelial stabilization.
Topics: Adherens Junctions; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Antigens, CD; beta Catenin; Brimonidine Tartrate; Cadherins; CD11b Antigen; Endothelium, Vascular; gamma Catenin; Humans; Idazoxan; Inflammation; Intercellular Adhesion Molecule-1; L-Selectin; Male; Mice; Neutrophils; Peritonitis; Quinoxalines; Receptors, Adrenergic, alpha-2; Thioglycolates; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha; Up-Regulation; Xylazine; Zymosan | 2014 |
[Erythema of rosacea: a new and effective treatment].
Topics: Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Erythema; Female; Humans; Male; Middle Aged; Quinoxalines; Rosacea; Treatment Outcome | 2014 |
Noradrenergic influences in the basolateral amygdala on inhibitory avoidance memory are mediated by an action on α2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Avoidance Learning; Basolateral Nuclear Complex; Brimonidine Tartrate; Idazoxan; Male; Memory; Microdialysis; Norepinephrine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2015 |
A novel in vivo model of focal light emitting diode-induced cone-photoreceptor phototoxicity: neuroprotection afforded by brimonidine, BDNF, PEDF or bFGF.
Topics: Animals; Brain-Derived Neurotrophic Factor; Brimonidine Tartrate; Cell Survival; Disease Models, Animal; Electronics; Eye Proteins; Female; Fibroblast Growth Factor 2; Light; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Rats, Sprague-Dawley; Retinal Cone Photoreceptor Cells; Serpins; Time Factors; Tomography, Optical Coherence | 2014 |
Anterior and posterior segment changes in rat eyes with chronic steroid administration and their responsiveness to antiglaucoma drugs.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Catalase; Dexamethasone; Disease Models, Animal; Female; Glutathione; Intraocular Pressure; Latanoprost; Male; Ocular Hypertension; Oxidative Stress; Pilocarpine; Prostaglandins F, Synthetic; Quinoxalines; Rats, Sprague-Dawley; Retina; Sulfonamides; Superoxide Dismutase; Thiophenes; Timolol | 2015 |
Multidimensional GPCR profiling and screening using impedance-based label-free and real-time assay.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Area Under Curve; Brimonidine Tartrate; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Discovery; Electric Impedance; HeLa Cells; High-Throughput Screening Assays; Humans; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Signal Transduction; Yohimbine | 2015 |
Totally one-sided: painless unilateral proptosis.
Topics: Aged, 80 and over; Antihypertensive Agents; Arteriovenous Fistula; Brimonidine Tartrate; Carotid Artery, Internal; Cavernous Sinus; Cerebral Angiography; Diagnosis, Differential; Exophthalmos; Female; Humans; Intraocular Pressure; Levobunolol; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiophenes; Tomography, X-Ray Computed; Treatment Outcome; Vision Disorders | 2015 |
Optimizing the use of topical brimonidine in rosacea management: panel recommendations.
Topics: Administration, Cutaneous; Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Dermatologic Agents; Gels; Humans; Quinoxalines; Rosacea; Treatment Outcome | 2015 |
Differential protection of injured retinal ganglion cell dendrites by brimonidine.
Topics: Animals; Brimonidine Tartrate; Cytoprotection; Dendrites; Female; Male; Mice; Mice, Inbred Strains; Microscopy, Fluorescence; Nerve Crush; Optic Nerve Injuries; Quinoxalines; Retinal Ganglion Cells | 2015 |
Diadenosine tetraphosphate improves adrenergic anti-glaucomatous drug delivery and efficiency.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Aqueous Humor; Blotting, Western; Brimonidine Tartrate; Cell Membrane Permeability; Cells, Cultured; Dinucleoside Phosphates; Drug Delivery Systems; Electric Impedance; Epithelium, Corneal; Glaucoma; Humans; Intraocular Pressure; Male; Occludin; Quinoxalines; Rabbits; Tight Junctions; Timolol; Zonula Occludens-1 Protein | 2015 |
Brimonidine suppresses loss of retinal neurons and visual function in a murine model of optic neuritis.
Topics: Administration, Ophthalmic; Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Female; Mice, Inbred C57BL; Nerve Growth Factors; Neuroprotective Agents; Ophthalmic Solutions; Optic Neuritis; Quinoxalines; Retinal Neurons; Up-Regulation | 2015 |
Neuropeptide Y as a presynaptic modulator of norepinephrine release from the sympathetic nerve fibers in the pig pineal gland.
Topics: Adrenergic Fibers; Animals; Brimonidine Tartrate; Female; Neuropeptide Y; Norepinephrine; Pineal Gland; Quinoxalines; Swine; Yohimbine | 2015 |
Topical Brimonidine Gel as a Hemostatic Agent After Dermatologic Surgery.
Topics: Adrenergic alpha-2 Receptor Agonists; Brimonidine Tartrate; Carcinoma, Basal Cell; Female; Gels; Hemostatics; Humans; Middle Aged; Mohs Surgery; Nose Neoplasms; Quinoxalines; Surgical Flaps | 2015 |
Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Cell Survival; Disease Models, Animal; Drug Carriers; Humans; Immunohistochemistry; Intravitreal Injections; Male; Nanoparticles; Nerve Crush; Optic Nerve; Optic Nerve Injuries; Quinoxalines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells; Serum Albumin | 2015 |
Safety concerns regarding use of topical brimonidine for hemostasis.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Hemostasis; Mohs Surgery; Pilot Projects; Quinoxalines | 2018 |
[Selective α2-agonists in the treatment of glaucoma: pharmacology, efficacy and safety].
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Ophthalmic Solutions; Quinoxalines | 2019 |
[Selective α2 agonists in the treatment of glaucoma: neuroprotective properties and impact on ocular blood flow].
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Brimonidine Tartrate; Glaucoma; Humans; Intraocular Pressure; Quinoxalines | 2019 |
Effect of over-the-counter brimonidine tartrate 0.025% ophthalmic solution on pupil size in healthy adults.
Topics: Adult; Brimonidine Tartrate; Humans; Lubricant Eye Drops; Miotics; Ophthalmic Solutions; Pupil; Quinoxalines | 2021 |
Can bleeding in trabeculectomy be decreased? Effectiveness of brimonidine pre-treatment.
Topics: Brimonidine Tartrate; Conjunctival Diseases; Eye Hemorrhage; Humans; Intraocular Pressure; Ophthalmic Solutions; Quinoxalines; Trabeculectomy | 2022 |
The benefit of scratch patch testing to demonstrate ocular contact allergy to brimonidine tartrate.
Topics: Adrenergic alpha-Agonists; Brimonidine Tartrate; Dermatitis, Allergic Contact; Humans; Patch Tests; Quinoxalines | 2022 |
Systemic toxicity from subcutaneous brimonidine injection successfully treated with naloxone.
Topics: Adrenergic alpha-Agonists; Aged; Analgesics, Opioid; Bradycardia; Brimonidine Tartrate; Drug Overdose; Female; Glaucoma; Humans; Hypotension; Infant; Injections, Subcutaneous; Lethargy; Naloxone; Ophthalmic Solutions; Quinoxalines | 2022 |
Intraocular pressure-lowering effects and safety of brimonidine/brinzolamide fixed combination after switching from other medications.
Topics: Antihypertensive Agents; Brimonidine Tartrate; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Ocular Hypertension; Ophthalmic Solutions; Quinoxalines; Sulfonamides; Thiazines | 2022 |
Response to Comments on
Topics: Animals; Brimonidine Tartrate; Drug Delivery Systems; Eye; Haplorhini; Quinoxalines | 2022 |
Comments on
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Drug Delivery Systems; Eye; Haplorhini; Intraocular Pressure; Ophthalmic Solutions; Quinoxalines | 2022 |
Cationic liposomes as promising vehicles for timolol/brimonidine combination ocular delivery in glaucoma: formulation development and in vitro/in vivo evaluation.
Topics: Animals; Antihypertensive Agents; Brimonidine Tartrate; Glaucoma; Intraocular Pressure; Liposomes; Polymers; Quinoxalines; Rabbits; Timolol | 2023 |
Brimonidine.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Brimonidine Tartrate; Glaucoma; Glaucoma, Open-Angle; Humans; Ophthalmic Solutions; Quinoxalines | 2023 |