quinoxalines and bms345541

Topics: Anti-Inflammatory Agents; Asthma; Heterocyclic Compounds, 3-Ring; Humans; I-kappa B Kinase; Imidazoles; NF-kappa B; Protein Serine-Threonine Kinases; Pulmonary Disease, Chronic Obstructive; Pyridines; Quinoxalines

Topics: Allosteric Site; Animals; Catalytic Domain; Enzyme Inhibitors; Female; I-kappa B Kinase; Imidazoles; Kinetics; Mice; Mice, Inbred BALB C; NF-kappa B; Protein Serine-Threonine Kinases; Quinoxalines; Transcription, Genetic

Topics: Administration, Oral; Animals; Arthritis, Experimental; Chronic Disease; Enzyme Inhibitors; I-kappa B Kinase; Imidazoles; Joints; Male; Mice; Mice, Inbred DBA; Protein Serine-Threonine Kinases; Quinoxalines

Topics: Animals; Cell Adhesion Molecules; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Endothelial Cells; Gene Expression Regulation; Humans; I-kappa B Kinase; Imidazoles; Intercellular Adhesion Molecule-1; Mice; Protein Serine-Threonine Kinases; Quinoxalines; Sulfasalazine; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1

Topics: Animals; Cadaver; CD40 Ligand; Enzyme Inhibitors; Female; Graft Rejection; Graft Survival; I-kappa B Kinase; Imidazoles; Interleukin-2; Mice; Mice, Inbred Strains; Protein Serine-Threonine Kinases; Quinoxalines

Topics: Animals; Antigens; Down-Regulation; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; Immunoglobulin E; Mast Cells; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Peptides; Protein Serine-Threonine Kinases; Quinoxalines; Receptors, IgE; Sulindac; Trinitrobenzenes; Tumor Necrosis Factor-alpha

Topics: ADAM Proteins; ADAMTS4 Protein; ADAMTS5 Protein; Aggrecans; Animals; Cartilage; Cattle; Chondrocytes; Collagen; Extracellular Matrix Proteins; Gene Expression Regulation, Enzymologic; Humans; Imidazoles; Interleukin-1; Lectins, C-Type; Metalloproteases; Phosphorylation; Procollagen N-Endopeptidase; Protein Kinase Inhibitors; Proteoglycans; Quinoxalines

Topics: Animals; Cell Death; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Deletion; I-kappa B Kinase; Imidazoles; Immunoblotting; Immunohistochemistry; Laser Scanning Cytometry; Mice; Neurons; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; Stroke

Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; I-kappa B Kinase; Imidazoles; In Vitro Techniques; Melanoma; Mice; Mitochondria; NF-kappa B; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Time Factors; Tumor Cells, Cultured

Topics: Cell Line; eIF-2 Kinase; Enzyme Activation; Humans; I-kappa B Kinase; Imidazoles; Interferon-gamma; Macrophage Activation; Monocytes; NF-kappa B; Phosphorylation; Quinoxalines; Receptors, IgG; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; Up-Regulation

Topics: Animals; Female; I-kappa B Kinase; Imidazoles; Immunity, Innate; Inflammation; Lipopolysaccharides; Lung; Lung Injury; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; NF-kappa B; Protein Kinase Inhibitors; Quinoxalines

Topics: Animals; Cell Line; Chlorocebus aethiops; Chromosomes, Mammalian; Cyclin A; Cyclin B; Cyclin B1; Humans; I-kappa B Kinase; Imidazoles; Mitosis; Quinoxalines; Spindle Apparatus; Telomerase

Topics: Activins; Aggrecans; Animals; Cartilage, Articular; Cytokines; Endopeptidases; Fibroblast Growth Factor 2; Fibroblasts; Humans; Imidazoles; NF-kappa B; Osteoarthritis, Knee; Pyrimidines; Quinoxalines; Smad2 Protein; Sus scrofa

Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cellular Senescence; Humans; Imidazoles; Necrosis; Neoplasms; NF-kappa B; Quinoxalines; Tumor Necrosis Factor-alpha

Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Biomarkers, Tumor; Dacarbazine; Drug Delivery Systems; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Melanoma; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Niacinamide; Phenylurea Compounds; Pyridines; Quinoxalines; Skin Neoplasms; Sorafenib; Substrate Specificity; Temozolomide; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

Topics: Administration, Oral; Animals; Apolipoprotein B-100; Cell Line, Tumor; Cell-Free System; Cricetinae; Cysteine Proteinase Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fructose; Gene Expression; Hepatocytes; Humans; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; Inflammation; Leupeptins; Lipid Metabolism; Lipoproteins; Lipoproteins, VLDL; Liver; Male; Mesocricetus; NF-kappa B; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Biosynthesis; Protein Kinase Inhibitors; Quinoxalines; Transfection; Tumor Necrosis Factor-alpha

Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; I-kappa B Kinase; Imidazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; NF-kappa B; Quinoxalines; Transcription Factor RelA; ZAP-70 Protein-Tyrosine Kinase

Topics: Bronchi; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Imidazoles; Immunoblotting; Immunohistochemistry; Myocytes, Smooth Muscle; NF-kappa B; Quinoxalines; rhoA GTP-Binding Protein; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation

Topics: Apoptosis; Benzamides; Blotting, Western; Caspase 3; Cell Proliferation; Cyclohexanones; Fluorescent Antibody Technique, Indirect; Humans; Imidazoles; Ki-67 Antigen; Liver Neoplasms; Melanoma; NF-kappa B; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Uveal Neoplasms

Topics: Antibiotics, Antineoplastic; Antibodies; Antioxidants; Apoptosis; bcl-X Protein; CASP8 and FADD-Like Apoptosis Regulating Protein; CD40 Antigens; Cell Line, Tumor; Dexamethasone; Doxorubicin; Glucocorticoids; Humans; I-kappa B Kinase; Imidazoles; Lymphoma, Follicular; NF-kappa B; Proline; Quinoxalines; Signal Transduction; Thiocarbamates; TNF-Related Apoptosis-Inducing Ligand

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Angiopoietin-2; Anthracyclines; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Cells, Cultured; Chemokines; Coculture Techniques; Culture Media, Serum-Free; Cytarabine; Diterpenes; Endothelial Cells; Female; Humans; Imidazoles; Leukemia, Myeloid; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Middle Aged; Neoplasm Proteins; NF-kappa B; Protease Inhibitors; Pyrazines; Quinoxalines; Receptor, TIE-2; Recombinant Proteins; Tissue Inhibitor of Metalloproteinases; Tumor Cells, Cultured

Topics: Boronic Acids; Bortezomib; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Fanconi Anemia; Fanconi Anemia Complementation Group D2 Protein; Gene Expression; Humans; Imidazoles; Melphalan; Multiple Myeloma; NF-kappa B; Pyrazines; Quinoxalines; Transcription Factor RelB

Topics: Adult; Amniotic Fluid; CD3 Complex; CD4-Positive T-Lymphocytes; Chorioamnionitis; Epithelial Cells; Female; Humans; I-kappa B Kinase; Imidazoles; Interleukin-17; Interleukin-8; Maternal-Fetal Exchange; Mitogen-Activated Protein Kinases; Obstetric Labor, Premature; Pregnancy; Quinoxalines; Tumor Necrosis Factor-alpha

Topics: Adult; Aged; Aged, 80 and over; Angiopoietin-1; Angiopoietin-2; Antibodies; Boronic Acids; Bortezomib; Cell Proliferation; Cells, Cultured; Coculture Techniques; Endothelial Cells; Female; Fibroblasts; Hepatocyte Growth Factor; Humans; Imidazoles; Interleukin-8; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplasm Proteins; Osteoblasts; Proteoglycans; Pyrazines; Quinoxalines; Receptor Cross-Talk; Receptor, TIE-2; Signal Transduction

Topics: Animals; Bronchi; Bronchial Hyperreactivity; I-kappa B Kinase; Imidazoles; Inflammation Mediators; Male; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Signal Transduction; Up-Regulation

Topics: Active Transport, Cell Nucleus; Antibodies, Monoclonal; Carrier Proteins; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Proliferation; Cyclin D3; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Gene Expression; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Humans; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; Interleukin-2; Interleukin-2 Receptor alpha Subunit; Intracellular Signaling Peptides and Proteins; Lymphocyte Activation; NF-kappa B; NF-KappaB Inhibitor alpha; Oncogene Proteins; Protein Kinase Inhibitors; Pyridines; Quinoxalines; S-Phase Kinase-Associated Proteins; Signal Transduction; Up-Regulation

Topics: Apoptosis; Apoptosis Regulatory Proteins; Baculoviral IAP Repeat-Containing 3 Protein; Base Sequence; Biomimetic Materials; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromones; Drug Resistance, Neoplasm; Humans; I-kappa B Kinase; Imidazoles; Inhibitor of Apoptosis Proteins; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mitochondrial Proteins; Morpholines; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; Up-Regulation

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Cell Differentiation; Cell Survival; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Female; Humans; I-kappa B Kinase; Imidazoles; Inhibitory Concentration 50; Mice; Osteoclasts; Ovariectomy; Pentacyclic Triterpenes; Quinoxalines; Sesquiterpenes; Signal Transduction; Triterpenes

Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Epidermal Cells; Female; Humans; Imidazoles; Keratinocytes; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Membrane Potentials; Middle Aged; Quinoxalines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand

Topics: Animals; Apoptosis; Cytokines; Diabetes Mellitus, Experimental; Graft Survival; Hypoxia; I-kappa B Kinase; Imidazoles; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; NF-kappa B; Oxygen; Portal Vein; Quinoxalines; Recombinant Proteins; Swine; Transplantation, Heterologous

Topics: AMP-Activated Protein Kinases; Animals; Benzamides; Cell Line; Embryo, Mammalian; Enzyme Activators; Fibroblasts; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Imidazoles; Matrix Metalloproteinase 9; Mice; Mice, Knockout; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Quinoxalines; Ribonucleotides; RNA, Messenger; Thiazoles

Topics: Animals; Blotting, Western; Cell Line, Tumor; Cells, Cultured; DNA Breaks, Double-Stranded; DNA Repair; Fibroblasts; Humans; I-kappa B Kinase; Imidazoles; Mice; Mice, Knockout; Polymerase Chain Reaction; Quinoxalines; Radiation, Ionizing; RNA, Small Interfering

Topics: Baculoviridae; Cytosol; Enzyme Activation; Gene Products, tax; Human T-lymphotropic virus 1; Humans; I-kappa B Kinase; Imidazoles; Immunoprecipitation; Jurkat Cells; MAP Kinase Kinase Kinase 1; Nitriles; Phosphorylation; Plasmids; Protein Interaction Mapping; Quinoxalines; Recombinant Proteins; Sulfones; Ubiquitination

Topics: Animals; Apoptosis; Becaplermin; Cartilage; Cell Differentiation; Cells, Cultured; Chondrocytes; Collagen Type II; Dogs; Down-Regulation; Enzyme Activation; Extracellular Matrix; Extracellular Signal-Regulated MAP Kinases; I-kappa B Proteins; Imidazoles; Insulin-Like Growth Factor I; Integrin beta1; Interleukin-1beta; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Quinoxalines; Shc Signaling Adaptor Proteins; Signal Transduction; SOX9 Transcription Factor; src-Family Kinases

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Enzyme Activation; Female; I-kappa B Kinase; Imidazoles; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Myelitis; Neuroprotective Agents; Neutrophil Infiltration; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord Injuries

Topics: Animals; Cell Line; Cricetinae; Cytokines; Enzyme Induction; Humans; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Macrophages; Monocytes; NF-kappa B; Quinoxalines; RNA, Messenger; RNA, Viral; Tryptophan; West Nile Fever; West Nile virus

Topics: Animals; Apoptosis; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Humans; I-kappa B Kinase; Imidazoles; Interleukin-1beta; Melanoma; Mice; Mice, Inbred C57BL; Myeloid Cells; Neutrophils; NF-kappa B; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction; Xenograft Model Antitumor Assays

Topics: Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Gene Silencing; Humans; I-kappa B Kinase; Imidazoles; Male; Prostatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Quinoxalines; Receptors, Androgen; Signal Transduction

Topics: Amides; Antiviral Agents; Cell Line, Tumor; Cell Proliferation; Cytopathogenic Effect, Viral; Encephalomyocarditis virus; Enzyme Activation; Gene Expression Regulation, Neoplastic; Glioma; Humans; I-kappa B Kinase; Imidazoles; Interferon Type I; Interleukin-8; NF-kappa B; Quinoxalines; Thiophenes; Vesicular stomatitis Indiana virus

Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O3; Forkhead Transcription Factors; G2 Phase Cell Cycle Checkpoints; Humans; I-kappa B Kinase; Imidazoles; M Phase Cell Cycle Checkpoints; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; NF-kappa B; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Quinoxalines; Receptor, Notch1; Signal Transduction; Tumor Suppressor Protein p53

Topics: Antineoplastic Agents; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; I-kappa B Kinase; Imidazoles; Quinoxalines

Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Breaks, Double-Stranded; DNA Repair; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Homologous Recombination; Humans; I-kappa B Kinase; Imidazoles; Mice; Protein Kinase Inhibitors; Quinoxalines

Topics: Cell Line; Cholesterol; Endoplasmic Reticulum; Foam Cells; Gene Expression Regulation; Golgi Apparatus; Humans; Hydroxymethylglutaryl CoA Reductases; I-kappa B Kinase; Imidazoles; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Lipoproteins, LDL; Membrane Proteins; Myeloid Differentiation Factor 88; NF-kappa B; Protein Transport; Quinoxalines; Receptors, LDL; RNA, Small Interfering; Sterol Regulatory Element Binding Protein 2; Toll-Like Receptor 4

Topics: Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Caspases; Cell Line, Tumor; Humans; I-kappa B Kinase; Imidazoles; Melanoma; Mitochondria; NF-kappa B; Oligopeptides; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Recombinant Proteins; RNA Interference; RNA, Small Interfering; TNF-Related Apoptosis-Inducing Ligand; X-Linked Inhibitor of Apoptosis Protein

Topics: Antigens, CD34; Boronic Acids; Bortezomib; Coculture Techniques; Drug Resistance, Neoplasm; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; I-kappa B Kinase; Imidazoles; Leukemia, Myeloid, Acute; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Neoplastic Stem Cells; NF-kappa B; Primary Cell Culture; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Quinoxalines; Recombinant Proteins; RNA, Small Interfering; Stromal Cells; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured

Topics: Animals; B-Lymphocytes; Burkitt Lymphoma; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Humans; Imidazoles; Lymphoma; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Quinoxalines; Reproducibility of Results; RNA, Long Noncoding

Topics: Androstadienes; Apoptosis; Arthritis, Rheumatoid; Bacterial Toxins; Cartilage; Caspase 3; Cells, Cultured; Chondrocytes; Cyclooxygenase 2; Extracellular Matrix; Humans; I-kappa B Kinase; Imidazoles; Immunoblotting; Lipopolysaccharides; Matrix Metalloproteinases; Microscopy, Electron; Microscopy, Fluorescence; NF-kappa B; Osteochondritis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Procollagen; Quinoxalines; Toll-Like Receptor 4; Wortmannin

Topics: Animals; Cycloheximide; Dactinomycin; Imidazoles; Leupeptins; Male; Muscle, Smooth, Vascular; NF-kappa B; Organ Culture Techniques; Quinoxalines; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Endothelin A; Receptor, Endothelin B; Renal Artery; Signal Transduction; Up-Regulation; Vasoconstriction; Viper Venoms

Topics: Animals; Antigens, CD; B7-1 Antigen; B7-2 Antigen; CD83 Antigen; Cell Line; Gene Expression; Imidazoles; Immunoglobulins; Macrophages; Membrane Glycoproteins; Mice; NF-kappa B; Oligodeoxyribonucleotides; Phagocytosis; Quinoxalines; Signal Transduction

Topics: Breast Neoplasms; COUP Transcription Factor II; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Hormones; Humans; Imidazoles; MCF-7 Cells; NF-kappa B; Phosphorylation; Protein Binding; Protein Subunits; Quinoxalines; RNA, Messenger; Signal Transduction; Transcription Factor RelA

Topics: Adult; Aged; Calcium Signaling; Electroporation; Female; Gene Expression Regulation, Leukemic; Humans; I-kappa B Kinase; Imidazoles; Immunoglobulin Heavy Chains; Immunoglobulin M; Immunoglobulin Variable Region; Interleukin-1beta; Interleukin-6; Interleukin-8; Interleukins; Jurkat Cells; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Proteins; NF-kappa B; Prognosis; Quinoxalines; Receptors, Antigen, B-Cell; Recombinant Fusion Proteins; RNA, Messenger; Transcription Factor RelA; Transcriptome; Tumor Cells, Cultured; ZAP-70 Protein-Tyrosine Kinase

Topics: Acute Lung Injury; Animals; Bacterial Infections; Cells, Cultured; I-kappa B Kinase; Imidazoles; Ligation; Macrophages; Mice; Neutrophils; NF-kappa B; Phagocytosis; Quinoxalines; Sepsis

Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; I-kappa B Kinase; I-kappa B Proteins; Imidazoles; MCF-7 Cells; NF-KappaB Inhibitor alpha; Phosphorylation; Pyrazines; Quinoxalines; Transcription Factor RelA

Topics: Antibodies; Apoptosis; Asthma; Cell Survival; Eosinophils; fas Receptor; Gene Expression Regulation; Gliotoxin; Humans; I-kappa B Kinase; Imidazoles; NF-kappa B; Phosphorylation; Primary Cell Culture; Protein Binding; Pyrrolidines; Quinoxalines; Receptors, Tumor Necrosis Factor, Type I; Retinoids; Signal Transduction; Thiocarbamates; Transcription Factor AP-1; Tumor Necrosis Factor-alpha

Topics: Adult; Calcifying Nanoparticles; Calcium Phosphates; Cell Culture Techniques; Cell Line; Cell Line, Tumor; Cell Nucleus; Cells, Cultured; Dental Calculus; Dose-Response Relationship, Drug; Durapatite; Epithelial Attachment; Female; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Interleukin-8; Male; MAP Kinase Signaling System; NF-kappa B; Particle Size; Quinoxalines; Signal Transduction; Transcription Factor RelA; Young Adult

Topics: Adolescent; Alkaline Phosphatase; Aluminum Compounds; Calcium; Calcium Compounds; Cell Differentiation; Cell Proliferation; Cell Shape; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Dentinogenesis; Drug Combinations; Extracellular Matrix Proteins; Humans; I-kappa B Proteins; Imidazoles; NF-kappa B; Odontogenesis; Osteocalcin; Osteogenesis; Oxides; Phosphoproteins; Quinoxalines; Root Canal Filling Materials; Sialoglycoproteins; Signal Transduction; Silicates; Stem Cells; Tooth Apex; Transcription Factor RelA; Up-Regulation; Young Adult

Topics: Acetylation; Cell Differentiation; Cells, Cultured; Chondrocytes; Chondrogenesis; Enzyme Activation; Enzyme Inhibitors; Gene Knockdown Techniques; Humans; I-kappa B Kinase; Imidazoles; Interleukin-1beta; Mesenchymal Stem Cells; NF-kappa B; Niacinamide; Quinoxalines; Resveratrol; Signal Transduction; Sirtuin 1; SOX9 Transcription Factor; Stilbenes

Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Baculoviral IAP Repeat-Containing 3 Protein; Caspase 3; Caspase 8; Cell Line, Tumor; Cycloheximide; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Inhibitor of Apoptosis Proteins; Leupeptins; NF-kappa B; Oligopeptides; Proteolysis; Quinoxalines; Signal Transduction; Survivin; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; X-Linked Inhibitor of Apoptosis Protein

Topics: B7-H1 Antigen; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Indoles; Interferon-gamma; Melanoma; NF-kappa B; Quinoxalines; Sulfonamides; Time Factors; Vemurafenib

Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Humans; I-kappa B Kinase; Imidazoles; In Situ Nick-End Labeling; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction

Topics: Amidines; Animals; Apoptosis; Arsenicals; Benzylamines; Cell Differentiation; Cell Line, Transformed; Cells, Cultured; Culture Media, Conditioned; Gene Expression Regulation; Hepatic Stellate Cells; Imidazoles; Interleukin-6; Liver; Liver Cirrhosis; Mice; Models, Biological; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Quinoxalines; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Stem Cells

Topics: Cell Line; Cells, Cultured; Chemokine CXCL10; Chemokine CXCL11; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Humans; I-kappa B Kinase; Imidazoles; Interferon-alpha; Interferon-gamma; Interferons; Keratinocytes; NF-kappa B; Plasmids; Promoter Regions, Genetic; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Transcription Factors

Topics: Apoptosis; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Curcumin; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Laryngeal Neoplasms; NF-kappa B; Quinoxalines; Tumor Necrosis Factor-alpha

Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Gangliosides; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Kinase; Imidazoles; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Neoplasm Metastasis; Neoplastic Stem Cells; Quinoxalines; RNA Interference; Sialyltransferases; Signal Transduction; Xenograft Model Antitumor Assays

Topics: Animals; Fatty Acids, Nonesterified; Female; I-kappa B Kinase; Imidazoles; Insulin-Secreting Cells; Mice; Oleic Acid; Oxidative Stress; Quinoxalines; Rats; Rats, Wistar; Salicylic Acid

Topics: Animals; Cell Line, Tumor; Female; Gangliosides; Humans; Imidazoles; Mice; Molecular Targeted Therapy; Neoplastic Stem Cells; NF-kappa B; Quinoxalines; Sialyltransferases; Signal Transduction; Triple Negative Breast Neoplasms

Topics: Airway Remodeling; Animals; Asthma; Epithelial-Mesenchymal Transition; Female; Imidazoles; Inflammation; Mice; Mice, Inbred BALB C; Quinoxalines

Topics: Breast Neoplasms; Carrier Proteins; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor Proteins; DNA Damage; DNA Repair; Etoposide; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; Imidazoles; MCF-7 Cells; Quinoxalines; Radiation-Sensitizing Agents; Radiation, Ionizing; Time Factors; Up-Regulation

Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Biopsy; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Immunohistochemistry; Injections, Intra-Articular; Mice; NF-kappa B; Osteoarthritis, Knee; Quinoxalines; Signal Transduction; Treatment Outcome

Topics: Animals; DNA Damage; DNA Repair; Feedback, Physiological; Gene Knockdown Techniques; Heterografts; Humans; Imidazoles; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred BALB C; Mice, Nude; NF-kappa B; Phthalazines; Piperazines; Poly (ADP-Ribose) Polymerase-1; Promoter Regions, Genetic; Quinoxalines; Transcription Factor RelA

Topics: Animals; Antioxidants; Aorta; Cyclic N-Oxides; Endothelial Cells; Endothelium, Vascular; I-kappa B Kinase; Imidazoles; Mechanistic Target of Rapamycin Complex 1; Mesenteric Arteries; Mice; Myography; Organ Culture Techniques; Quinoxalines; Reactive Oxygen Species; Signal Transduction; Spin Labels; Vasodilation

Topics: Adiponectin; Animals; Bone Marrow; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mice; Multiple Myeloma; Nerve Growth Factor; Neuroglia; NF-kappa B; Osteoblasts; Pain; Peptides; Piperidines; Quinoxalines; Stromal Cells; Tumor Microenvironment; Tumor Necrosis Factor-alpha

Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cinnamates; Colorectal Neoplasms; Curcuma; Curcumin; Humans; Imidazoles; Lymphotoxin-alpha; Monoterpenes; Neoplasm Invasiveness; Neoplasm Metastasis; Quinoxalines; Signal Transduction; Transcription Factor RelA

Topics: Acetophenones; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Capsaicin; Enzyme Inhibitors; Furans; Imidazoles; Indenes; Interleukin-1beta; Kidney; Losartan; Male; Paraventricular Hypothalamic Nucleus; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reflex; Sulfonamides; Superoxides; Sympathetic Nervous System; Transcription Factor RelA

Topics: Apoptosis; Cartilage; Cells, Cultured; Chondrocytes; Curcuma; Curcumin; Cyclooxygenase 2; Humans; I-kappa B Kinase; Imidazoles; Inflammation; Interleukin-1beta; NF-kappa B; Osteoarthritis; Primary Cell Culture; Quinoxalines; Signal Transduction; SOX9 Transcription Factor; Tumor Necrosis Factor-alpha

Topics: Cell Line; Cyclopropanes; Humans; Imidazoles; Inflammation Mediators; Interleukin-6; Lipopolysaccharides; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinoxalines; Senescence-Associated Secretory Phenotype; Senotherapeutics; Signal Transduction; Tumor Necrosis Factor-alpha