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quinoxalines and as 605240

quinoxalines has been researched along with as 605240 in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's11 (18.33)29.6817
2010's47 (78.33)24.3611
2020's2 (3.33)2.80

Authors

AuthorsStudies
Balomenos, D; Barber, DF; Bartolomé, A; Camps, M; Carrera, AC; Fernandez-Arias, C; Flores, JM; Hernandez, C; Martinez-A, C; Redondo, C; Rodríguez, S; Rommel, C; Rückle, T; Schwarz, MK1
Ardissone, V; Camps, M; Chabert, C; Cirillo, R; Ferrandi, C; Françon, B; Gillieron, C; Gretener, D; Hirsch, E; Ji, H; Leroy, D; Martin, T; Perrin, D; Rintelen, F; Rommel, C; Rückle, T; Schwarz, MK; Shaw, J; Vitte, PA; Wymann, MP1
Ohashi, PS; Woodgett, JR1
Doggrell, SA1
Backi, M; Bohle, RM; Briles, D; Hirsch, E; Lohmeyer, J; Mack, M; Maus, R; Maus, UA; Paton, JC; Preissner, KT; Rommel, C; Rückle, T; Schwarz, MK; Seeger, W; Srivastava, M; Welte, T; Winter, C1
Haruta, K; Tamura, N1
Arnal, JF; Breton-Douillon, M; Fougerat, A; Gayral, S; Gourdy, P; Hirsch, E; Laffargue, M; Perret, B; Rommel, C; Rückle, T; Salles, JP; Schambourg, A; Schwarz, MK; Wymann, MP1
Endo, D; Gon, Y; Hashimoto, S; Nunomura, S; Ra, C; Yamashita, K1
Chen, LJ; Chen, ZZ; He, CM; Hu, XH; Ke, J; Luo, YF; Peng, XD; Song, LF; Wang, YS; Wang, ZL; Wei, YQ; Wu, XH; Zhang, W1
Ball, BJ; Hoppa, MB; Kolic, J; MacDonald, PE; Manning Fox, JE; Pigeau, GM; Rückle, T; Wang, YW; Woo, M1
Ley, K; Reutershan, J; Rückle, T; Saprito, MS; Wu, D1
Chen, LJ; Chen, ZZ; He, CM; Hu, XH; Jin, K; Li, XL; Lin, HG; Luo, YF; Peng, XD; Song, LF; Wang, YS; Wang, ZL; Wei, YQ; Wu, XH1
Kettritz, R; Luft, FC; Peripelittchenko, L; Rademann, J; Rolle, S; Schneider, W; Schreiber, A1
He, CM; Hu, XH; Jin, K; Song, LF; Wang, ZL; Wu, XH1
Damilano, F; Emanueli, C; Hirsch, E; Katare, R; Madeddu, P; Meloni, M; Siragusa, M1
Bauer, R; Grün, M; König, C; Marone, R; Müller, JP; Röpke, L; Rubio, I; Spitzenberg, V; Ulm, S; Voigt, A; Wetzker, R; Wymann, MP1
Chen, LJ; Chen, ZZ; Han, J; Luo, YF; Ma, YH; Qi, BW; Wang, GC; Wei, X; Wei, YQ; Zheng, H1
Abbate, A; Mezzaroma, E; Seropian, IM; Toldo, S; Van Tassell, BW1
Carlotti, A; Douguet, L; Dupin, N; Dwyer, J; Galan Moya, EM; Gavard, J; Grange, PA; Gutkind, JS; Le Guelte, A; Sumbal, M1
Barbero, A; Benvenuto, F; Bocelli-Tyndall, C; Di Maggio, N; Iezzi, G; Martin, I; Pistoia, V; Schaeren, S; Scherberich, A; Spagnoli, G; Trella, E; Tyndall, A; Vukcevic, M; Zajac, P1
Abbate, A; Damilano, F; Harrington, J; Hirsch, E; Mezzaroma, E; Ockaili, R; Seropian, IM; Smithson, L; Toldo, S; Van Tassell, BW1
Bento, AF; Calixto, JB; Claudino, RF; Cola, M; Dutra, RC; Leal, PC; Leite, DF; Nascimento, AF1
Arnoletti, E; Baragli, A; Ghè, C; Ghigo, E; Granata, R; Muccioli, G1
Awazawa, M; Goyama, S; Hara, K; Iwane, A; Kadowaki, T; Kaneko, K; Kobayashi, M; Kobayashi, N; Koshima, I; Kubota, N; Kurokawa, M; Murakami, K; Nagai, R; Nishikawa, Y; Ohsugi, M; Okazaki, Y; Sasaki, J; Sasaki, T; Sasako, T; Suzuki, M; Ueki, K; Yoshimura, K1
Altruda, F; Baillie, GS; Damilano, F; Dunlop, AJ; Ferrero, E; Ghigo, A; Heymans, S; Hirsch, E; Houslay, MD; Iaccarino, G; Langeberg, LK; Lembo, G; Levi, R; Morello, F; Neubauer, G; Pawson, C; Perino, A; Santulli, G; Scott, JD; Silengo, L; Walser, R; Wetzker, R; Wymann, MP1
Affolter, M; Belting, HG; Blondelle, J; Epstein, JA; Flaherty, KM; Gay, CM; Herwig, L; Krudewig, A; Means, PC; Singh, MK; Torres-Vázquez, J; Zygmunt, T1
Hu, XH; Jiang, W; Li, Y; Qing, Y; Song, LF; Tong, QY; Wu, XH1
Campos, MM; Lazarotto, LF; Leal, PC; Lopes, TG; Morrone, FB; Pereira, PJS1
Ahn, SJ; Backx, PH; Baek, J; Bradley, CA; Choi, JH; Choi, SY; Collingridge, GL; Jang, DJ; Kaang, BK; Kim, E; Kim, H; Kim, JI; Kim, KH; Kim, SJ; Ko, HG; Kwak, C; Lee, HR; Lee, K; Lee, YS; Park, SW; Sim, SE; Yu, NK; Zhuo, M1
Carnevale, D; Cifelli, G; Ciraolo, E; Damato, A; Esposito, G; Franco, E; Frati, G; Fucile, S; Grieco, P; Haase, H; Hirsch, E; Landolfi, A; Lembo, G; Maffei, A; Martinello, K; Mascio, G; Mazzoni, O; Selvetella, G; Vecchione, C1
Anzinger, JJ; Barthwal, MK; Bohnacker, T; Chang, J; Kruth, HS; Wymann, MP; Xu, Q1
Im, MJ; Kim, DI; Kim, HJ; Kim, SR; Lee, HB; Lee, SJ; Lee, YC; Park, SJ1
Barbi, J; Cummings, HE; Keiser, TL; Lezama-Davila, C; Lu, B; Oghumu, S; Radzioch, D; Reville, P; Rommel, C; Rückle, T; Sarkar, A; Satoskar, AR; Seveau, S; Varikuti, S; Wewers, MD; Whitacre, C; Zorko, N1
Abdi, R; Azzi, J; El Haddad, N; Elyaman, W; Fiorina, P; Jurewicz, M; Moore, RF; Mounayar, M; Petrelli, A; Ruckle, T; Takakura, A; Yang, S1
Jeong, JS; Kim, DI; Kim, HJ; Kim, SR; Lee, YC; Park, JK1
Comerford, I; Kara, E; Litchfield, W; McColl, SR1
Chihara, J; Ito, W; Itoga, M; Kobayashi, Y; Konno, Y; Moritoki, Y; Nishikawa, J; Saito, Y; Takeda, M; Tamaki, M; Ueki, S1
Dayan, CM; Draman, MS; Grennan-Jones, F; Lane, C; Ludgate, M; Morris, D; Tee, AR; Zhang, L1
Barber, DF; Cariaga, AE; Carrera, AC; García, E; Puri, KD; Rojas, JM; Steiner, BH; Suárez-Fueyo, A1
Calise, D; Gadeau, AP; Gayral, S; Goudounèche, D; Hirsch, E; Kassem, S; Laffargue, M; Loirand, G; Malet, N; Martinez, LO; Pedros, C; Saoudi, A; Smirnova, NF; Vaillant, N; Wymann, MP1
Amaral-Martins, F; Campos, AC; de Oliveira, AC; Fiebich, BL; Lima, IV; Miranda, AS; Moraes, MF; Santos, RP; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP; Vieira, ÉL; Vieira, LB1
Brant, F; Lacerda-Queiroz, N; Rachid, MA; Rodrigues, DH; Sousa, LP; Teixeira, AL; Teixeira, MM; Vago, JP1
Barata, JT; Brandalise, SR; Cardoso, BA; Laranjeira, AB; Leal, PC; Rodrigues, GO; Silveira, AB; Yunes, JA; Yunes, RA; Zanchin, NI1
Horiguchi, M; Motomura, T; Oiso, Y; Sakai, H; Yamashita, C1
Bogo, MR; Campos, MM; Canevese, FF; Cheng, YC; Danesi, GM; Laedermann, C; Lerner, EA; Machado, GD; Pereira, PJ; Pereira, TC; Reddy, VB; Talbot, S1
Albertine, KH; Cai, L; Cho, J; Dai, Z; Huang, X; Malik, AB; Schraufnagel, DE; Sun, K; Zhao, YY1
Abdi, R; Abdoli, R; Azzi, J; Moore, R; Reijonen, H; Thueson, L1
Fan, TT; Feng, XY; Gao, F; Liu, Q; Yang, YZ1
Barata, JT; Bertaina, A; Buontempo, F; Cappellini, A; Chiarini, F; Evangelisti, C; Fragoso, R; Locatelli, F; Lonetti, A; Manzoli, L; Martelli, AM; Neri, LM; Oliveira, M; Orsini, E; Pession, A; Simioni, C1
Amaral, MEA; Bogo, MR; Campos, MM; Filippi-Chiela, EC; Kist, LW; Mascarello, A; Mielcke, TR; Muradás, TC; Neuenfeldt, PD; Nunes, RJ1
Ameri, P; Angelini, A; Bornbaum, J; Cappello, P; Cimino, J; De Santis, MC; Di Bona, A; Franco, I; Ghigo, A; Heger, J; Hirsch, E; Lazzarini, E; Li, M; Lima, BHF; Lima-Júnior, RCP; Margaria, JP; Martini, M; Mongillo, M; Morello, F; Novelli, F; Perino, A; Pianca, N; Pirozzi, F; Porporato, PE; Rohrbach, S; Rossi, L; Sala, V; Sandri, M; Schulz, R; Sciarretta, S; Teixeira, MM; Tocchetti, CG; Zaglia, T1
Alves-Filho, JC; Baron, M; Cardozo, LE; Chevillard, C; Cunha, FQ; Cunha, TM; Cunha-Neto, E; Davoli-Ferreira, M; Dias, FC; Figueiredo, F; Frade, AF; Gava, FN; Hirsch, E; Lopes, CD; Lyroni, K; Medina, TS; Nakaya, HI; Sesti-Costa, R; Silva, GK; Silva, JS; Silva, MC; Tsatsanis, C1
Chen, L; Feng, Y; Gan, H; Haydon, RC; He, TC; Huang, B; Huang, S; Lei, J; Liu, W; Luo, W; Luu, HH; Shu, Y; Wang, X; Xia, Y; Yan, S; Yu, X; Yuan, C; Zeng, L; Zeng, Z; Zhang, B; Zhang, H; Zhang, L; Zhang, R; Zhang, X; Zhao, C1
Jin, R; Li, G; Li, J; Wang, M; Xiao, AY1
Araújo, SB; Calixto, JB; Costa, R; Fernandes, ES; Manjavachi, MN; Passos, GF; Pontes, JP; Trevisan, G1
Balasubramanian, N; Khlebnikov, AI; Kirpotina, LN; Quinn, MT; Schepetkin, IA1
Ding, Y; Fan, F; Hu, E; Liu, L; Lu, X; Shang, S; Wang, L; Wu, X; Zhang, Y1
Amour, A; Gomides, LF; Hessel, EM; Hirsch, E; Kraemer, L; Lennon, M; Lima, BHF; Marques, PE; Mattos, MS; Menezes, GB; Queiroz-Junior, CM; Russo, RC; Teixeira, MM1
Jin, R; Li, G; Liu, S; Wang, M; Zhong, W1
Alves Lemos, SI; Araújo, ASML; Barbosa, ALR; da Rocha Rodrigues, L; de Brito, TV; de Carvalho Filgueiras, M; de Oliveira, JC; de Oliveira, JS; Dos Santos Ferreira, J; Franco, ÁX; Júnior, GJD; Lima, JVDN; Monteiro, CE; Oliveira Silva, FG; Pereira Alves, EH; Pereira Vasconcelos, DF; Pereira, CMC; Soares, PMG1

Reviews

1 review(s) available for quinoxalines and as 605240

ArticleYear
[Therapeutic potential of phosphoinositide 3-kinase inhibitors in rheumatoid arthritis].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2007, Volume: 30, Issue:5

    Topics: Animals; Arthritis, Rheumatoid; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

2007

Other Studies

59 other study(ies) available for quinoxalines and as 605240

ArticleYear
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.
    Nature medicine, 2005, Volume: 11, Issue:9

    Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Mice; Mice, Mutant Strains; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

2005
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.
    Nature medicine, 2005, Volume: 11, Issue:9

    Topics: Animals; Arthritis, Rheumatoid; Binding Sites; Chemotaxis, Leukocyte; Dioxoles; Disease Models, Animal; Enzyme Inhibitors; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Knockout; Molecular Sequence Data; Molecular Structure; Peritonitis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Thiazolidinediones

2005
Modulating autoimmunity: pick your PI3 kinase.
    Nature medicine, 2005, Volume: 11, Issue:9

    Topics: Animals; Arthritis; Autoimmune Diseases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

2005
Phosphoinositide 3-kinase-gamma as a target in rheumatoid arthritis and systemic lupus.
    Expert opinion on therapeutic targets, 2006, Volume: 10, Issue:4

    Topics: Animals; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Mice; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

2006
Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.
    American journal of respiratory and critical care medicine, 2007, May-01, Volume: 175, Issue:9

    Topics: Animals; Bacterial Proteins; Chemokine CCL2; Chemotaxis, Leukocyte; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Gene Deletion; Immunity, Innate; Isoenzymes; MAP Kinase Signaling System; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pneumonia, Pneumococcal; Quinoxalines; Streptolysins; Thiazolidinediones

2007
Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.
    Circulation, 2008, Mar-11, Volume: 117, Issue:10

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Humans; Inflammation; Intramolecular Oxidoreductases; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-E Synthases; Quinoxalines; Receptors, LDL; Thiazolidinediones

2008
PI3Kgamma differentially regulates FcepsilonRI-mediated degranulation and migration of mast cells by and toward antigen.
    International archives of allergy and immunology, 2009, Volume: 149 Suppl 1

    Topics: Animals; Antigens; Cell Degranulation; Cell Movement; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Immunoglobulin E; Isoenzymes; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Receptors, IgE; Thiazolidinediones

2009
Phosphoinositide 3-kinase gamma inhibitor ameliorates concanavalin A-induced hepatic injury in mice.
    Biochemical and biophysical research communications, 2009, Sep-04, Volume: 386, Issue:4

    Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Class Ib Phosphatidylinositol 3-Kinase; Concanavalin A; Cytokines; Enzyme Inhibitors; Isoenzymes; Liver; Liver Cirrhosis; Mice; Mitogens; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones

2009
Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells.
    Diabetes, 2009, Volume: 58, Issue:9

    Topics: Actins; Animals; Calcium Channels; Cell Line, Tumor; Class Ib Phosphatidylinositol 3-Kinase; Exocytosis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Isoenzymes; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pancreatic Neoplasms; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; RNA, Small Interfering; Secretory Vesicles; Thiazolidinediones

2009
Phosphoinositide 3-kinase gamma required for lipopolysaccharide-induced transepithelial neutrophil trafficking in the lung.
    The European respiratory journal, 2010, Volume: 35, Issue:5

    Topics: Acute Lung Injury; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Chimera; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lipopolysaccharides; Lung; Male; Membrane Proteins; Mice; Neutrophils; Phosphatidylinositol 3-Kinases; Quinoxalines; Thiazolidinediones

2010
Inhibition of phosphoinositide 3-kinase ameliorates dextran sodium sulfate-induced colitis in mice.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:1

    Topics: Acute Disease; Animals; Blotting, Western; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Organ Size; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Severity of Illness Index; Spleen; Thiazolidinediones

2010
Phosphoinositol 3-kinase-gamma mediates antineutrophil cytoplasmic autoantibody-induced glomerulonephritis.
    Kidney international, 2010, Volume: 77, Issue:2

    Topics: Animals; Antibodies, Antineutrophil Cytoplasmic; Cell Adhesion; Cell Degranulation; Cell Movement; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Female; Glomerulonephritis; Humans; Isoenzymes; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Reactive Oxygen Species; Thiazolidinediones

2010
[Intervention effect of PI3Kgamma inhibitor AS605240 on autoimmune myocarditis in mice].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2009, Volume: 40, Issue:5

    Topics: Animals; Autoimmune Diseases; Chemokine CCL2; Class Ib Phosphatidylinositol 3-Kinase; Down-Regulation; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Myocarditis; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Random Allocation; Thiazolidinediones; Tumor Necrosis Factor-alpha

2009
Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice.
    Circulation research, 2010, Mar-05, Volume: 106, Issue:4

    Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Inflammation; Leukocytes; Male; Mice; Morpholines; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Recovery of Function; Regeneration; RNA Interference; Signal Transduction; Thiazolidinediones; Time Factors; Transfection; Ventricular Function, Left

2010
Targeting PI3K in neuroblastoma.
    Journal of cancer research and clinical oncology, 2010, Volume: 136, Issue:12

    Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, SCID; Neuroblastoma; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; Thiazolidinediones; Tumor Burden; Xenograft Model Antitumor Assays

2010
A phosphoinositide 3-kinase-gamma inhibitor, AS605240 prevents bleomycin-induced pulmonary fibrosis in rats.
    Biochemical and biophysical research communications, 2010, Jun-25, Volume: 397, Issue:2

    Topics: Animals; Bleomycin; Enzyme Inhibitors; Female; Phosphoinositide-3 Kinase Inhibitors; Pulmonary Fibrosis; Quinoxalines; Rats; Rats, Sprague-Dawley; Thiazolidinediones

2010
Effects of PI3Kgamma inhibition using AS-605240 in acute myocardial infarction.
    Circulation research, 2010, Jul-23, Volume: 107, Issue:2

    Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Genotype; Mice; Mice, Knockout; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinoxalines; Thiazolidinediones; Ventricular Function, Left; Ventricular Remodeling

2010
Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.
    Oncogene, 2011, Jan-13, Volume: 30, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Androstadienes; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cell Line; Chromones; Cinnamates; Endothelial Cells; Enzyme Inhibitors; Female; Furans; Herpesvirus 8, Human; Humans; Indoles; Intercellular Junctions; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Pyridines; Pyrimidines; Quinoxalines; Receptors, Chemokine; RNA, Small Interfering; Sarcoma, Kaposi; Skin; Skin Neoplasms; Sulfonamides; Thiazolidinediones; Wortmannin

2011
Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:12

    Topics: Cell Proliferation; Cells, Cultured; Chromones; Fibroblast Growth Factor 2; Flavonoids; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Interferon-gamma; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones; Trans-Activators

2010
Pharmacologic inhibition of phosphoinositide 3-kinase gamma (PI3Kγ) promotes infarct resorption and prevents adverse cardiac remodeling after myocardial infarction in mice.
    Journal of cardiovascular pharmacology, 2010, Volume: 56, Issue:6

    Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones; Ventricular Remodeling

2010
Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells.
    British journal of pharmacology, 2011, Volume: 163, Issue:2

    Topics: Animals; Apoptosis; CD4 Antigens; Cells, Cultured; Colitis; Colon; Cytokines; Forkhead Transcription Factors; Interleukin-2 Receptor alpha Subunit; Intestinal Mucosa; Male; Matrix Metalloproteinase 9; Mice; Neutrophil Infiltration; Neutrophils; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; T-Lymphocytes, Regulatory; Thiazolidinediones; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A

2011
Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
    Biochimica et biophysica acta, 2011, Volume: 1811, Issue:6

    Topics: Acylation; Adipocytes; Adrenergic beta-Agonists; Animals; Benzimidazoles; Blotting, Western; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Interactions; Ghrelin; Glycerol; Intra-Abdominal Fat; Isoproterenol; Lipolysis; Male; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; Quinoxalines; Rats; Rats, Wistar; Thiazolidinediones

2011
Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Apr-05, Volume: 108, Issue:14

    Topics: Adipose Tissue; Animals; Class Ib Phosphatidylinositol 3-Kinase; Flow Cytometry; Gene Expression Profiling; Histological Techniques; Inflammation; Insulin Resistance; Liver; Macrophages; Mice; Mice, Knockout; Obesity; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

2011
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
    Molecular cell, 2011, Apr-08, Volume: 42, Issue:1

    Topics: A Kinase Anchor Proteins; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Class Ib Phosphatidylinositol 3-Kinase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; DNA; Enzyme Activation; Enzyme Inhibitors; Heart Failure; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Myocytes, Cardiac; Peptide Fragments; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Interaction Mapping; Quinoxalines; Receptors, Adrenergic, beta; Second Messenger Systems; Sequence Homology, Amino Acid; Thiazolidinediones

2011
Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1.
    Developmental cell, 2011, Aug-16, Volume: 21, Issue:2

    Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Aorta; Cell Movement; Cell Transplantation; Embryo, Nonmammalian; Endothelial Cells; Endothelium; Gene Expression Regulation, Developmental; In Vitro Techniques; Indoles; Luminescent Proteins; Molecular Sequence Data; Neovascularization, Physiologic; Oligodeoxyribonucleotides, Antisense; Pyrroles; Quinoxalines; Receptors, Cell Surface; Receptors, Notch; RNA, Messenger; Semaphorins; Signal Transduction; Thiazolidinediones; Vascular Endothelial Growth Factor Receptor-1; Zebrafish; Zebrafish Proteins

2011
[The antagonistic effect of PI3K-gamma inhibitor AS605240 on cardiac hypertrophy and cardiac fibrosis induced by isoproterenol in rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011, Volume: 42, Issue:4

    Topics: Animals; Cardiomegaly; Fibrosis; Isoproterenol; Male; Myocardium; Proteasome Endopeptidase Complex; Proteins; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Thiazolidinediones

2011
Inhibition of phosphatidylinositol-3 kinase γ reduces pruriceptive, inflammatory, and nociceptive responses induced by trypsin in mice.
    Pain, 2011, Volume: 152, Issue:12

    Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Inflammation; Injections, Intraventricular; Male; Mice; Neural Inhibition; Neuralgia; Neuritis; Nociception; Phosphoinositide-3 Kinase Inhibitors; Pruritus; Quinoxalines; Thiazolidinediones; Trypsin

2011
PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility.
    Nature neuroscience, 2011, Oct-23, Volume: 14, Issue:11

    Topics: Analysis of Variance; Animals; Behavior, Animal; Biophysics; Chromones; Class Ib Phosphatidylinositol 3-Kinase; Conditioning, Classical; Electric Stimulation; Environment; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exploratory Behavior; Extinction, Psychological; Fear; Female; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Male; Maze Learning; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Neurons; Oncogene Protein v-akt; Phosphorylation; Quinoxalines; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Thiazolidinediones; Time Factors

2011
PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism.
    Cardiovascular research, 2012, Jan-01, Volume: 93, Issue:1

    Topics: Animals; Blood Pressure; Calcium Channels, L-Type; Calcium Signaling; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Hypertension; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones; Vasodilation

2012
Murine bone marrow-derived macrophages differentiated with GM-CSF become foam cells by PI3Kγ-dependent fluid-phase pinocytosis of native LDL.
    Journal of lipid research, 2012, Volume: 53, Issue:1

    Topics: Animals; Cell Differentiation; Cholesterol, LDL; Class Ib Phosphatidylinositol 3-Kinase; Foam Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Pinocytosis; Quinoxalines; Thiazolidinediones

2012
PI3K-γ inhibition ameliorates acute lung injury through regulation of IκBα/NF-κB pathway and innate immune responses.
    Journal of clinical immunology, 2012, Volume: 32, Issue:2

    Topics: Acute Lung Injury; Animals; Cell Nucleus; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Dendritic Cells; Enzyme Activation; Female; I-kappa B Proteins; Immunity, Innate; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Peroxidase; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Quinoxalines; Reactive Oxygen Species; Signal Transduction; Thiazolidinediones; Toll-Like Receptor 4; Vascular Endothelial Growth Factor A

2012
Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Jan-24, Volume: 109, Issue:4

    Topics: Animals; Antimony Sodium Gluconate; Disease Resistance; Flow Cytometry; Host-Parasite Interactions; Humans; Leishmania mexicana; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neutrophils; Phagocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

2012
The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes.
    Diabetes, 2012, Volume: 61, Issue:6

    Topics: Animals; Diabetes Mellitus, Type 1; Female; Hyperglycemia; Mice; Mice, Inbred NOD; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Spleen; T-Lymphocytes, Regulatory; Thiazolidinediones

2012
PI3Kγ activation is required for LPS-induced reactive oxygen species generation in respiratory epithelial cells.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012, Volume: 61, Issue:11

    Topics: Cell Line; Cell Line, Tumor; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Epithelial Cells; Humans; Hydrogen Peroxide; Lipopolysaccharides; Lung; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Reactive Oxygen Species; RNA, Small Interfering; Thiazolidinediones

2012
PI3Kγ drives priming and survival of autoreactive CD4(+) T cells during experimental autoimmune encephalomyelitis.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Administration, Oral; Animals; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Movement; Cell Survival; Central Nervous System; Class Ib Phosphatidylinositol 3-Kinase; Cross-Priming; Cytokines; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Deletion; Humans; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction; Th1 Cells; Th17 Cells; Thiazolidinediones

2012
The effect of pharmacological PI3Kγ inhibitor on eotaxin-induced human eosinophil functions.
    Pulmonary pharmacology & therapeutics, 2014, Volume: 27, Issue:2

    Topics: Chemokine CCL11; Chemotaxis; Class Ib Phosphatidylinositol 3-Kinase; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Eosinophil-Derived Neurotoxin; Eosinophils; Flow Cytometry; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Thiazolidinediones

2014
Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy.
    The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:7

    Topics: Adipogenesis; Cells, Cultured; Chromones; Drug Discovery; Gene Expression Regulation; Graves Ophthalmopathy; Humans; Hyaluronic Acid; Molecular Targeted Therapy; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinoxalines; Receptor, IGF Type 1; Receptors, Thyrotropin; Signal Transduction; Thiazolidinediones

2014
Inhibition of PI3Kδ reduces kidney infiltration by macrophages and ameliorates systemic lupus in the mouse.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Jul-15, Volume: 193, Issue:2

    Topics: Adenosine; Animals; Antibodies, Antinuclear; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Dose-Response Relationship, Drug; Flow Cytometry; Immunoglobulin G; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphocyte Count; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Microscopy, Confocal; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolinones; Quinoxalines; Survival Analysis; Thiazolidinediones

2014
Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response.
    The Journal of experimental medicine, 2014, Aug-25, Volume: 211, Issue:9

    Topics: Animals; Carotid Artery Injuries; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Femoral Artery; Gene Targeting; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neointima; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Th1 Cells; Thiazolidinediones

2014
PI3Kγ deficiency enhances seizures severity and associated outcomes in a mouse model of convulsions induced by intrahippocampal injection of pilocarpine.
    Experimental neurology, 2015, Volume: 267

    Topics: Animals; Calcium; Calcium-Binding Proteins; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Doublecortin Domain Proteins; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microtubule-Associated Proteins; Muscarinic Agonists; Neuropeptides; Pilocarpine; Prefrontal Cortex; Quinoxalines; Reaction Time; Seizures; Synaptosomes; Thiazolidinediones; Time Factors

2015
Phosphatidylinositol 3-Kinase γ is required for the development of experimental cerebral malaria.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Animals; Brain; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Extracellular Matrix; Female; Humans; Lung; Malaria, Cerebral; Mice; Phosphoinositide-3 Kinase Inhibitors; Plasmodium berghei; Quinoxalines; Survival Analysis; Thiazolidinediones

2015
PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia.
    Oncotarget, 2015, May-30, Volume: 6, Issue:15

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Glucocorticoids; Humans; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein Kinase Inhibitors; Quinoxalines; Random Allocation; Signal Transduction; Thiazolidinediones; Xenograft Model Antitumor Assays

2015
Pulmonary administration of phosphoinositide 3-kinase inhibitor is a curative treatment for chronic obstructive pulmonary disease by alveolar regeneration.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, Sep-10, Volume: 213

    Topics: Androstadienes; Animals; Cell Differentiation; Cell Line; Humans; Hydrazones; Lung; Male; Mice, Inbred ICR; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Quinoxalines; Regeneration; Stem Cells; Sulfonamides; Thiazolidinediones; Wortmannin

2015
GRPR/PI3Kγ: Partners in Central Transmission of Itch.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Dec-09, Volume: 35, Issue:49

    Topics: Action Potentials; Animals; Anticarcinogenic Agents; Bombesin; Capsaicin; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Gastrin-Releasing Peptide; Indoles; Male; Mice; Neurons; p-Methoxy-N-methylphenethylamine; Pain Threshold; Peptide Fragments; Phosphatidylinositol 3-Kinase; Pruritus; Quinoxalines; Reaction Time; Receptors, Bombesin; Synaptic Transmission; Thiazolidinediones

2015
Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular Injury.
    Circulation, 2016, Mar-15, Volume: 133, Issue:11

    Topics: Androstadienes; Animals; Capillary Leak Syndrome; Capillary Permeability; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Forkhead Box Protein M1; Forkhead Transcription Factors; Furans; Humans; Lung; Mice; Mice, Knockout; Microvessels; Neutrophils; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Pulmonary Edema; Pyridines; Pyrimidines; Quinoxalines; Recombinant Fusion Proteins; Regeneration; Respiratory Distress Syndrome; Sepsis; Signal Transduction; Thiazolidinediones; Transfection; Wortmannin

2016
PI3Kγ Deficient NOD-Mice Are Protected from Diabetes by Restoring the Balance of Regulatory to Effector-T-Cells.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cell Survival; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Humans; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Pancreas; Peptides; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; T-Lymphocytes, Regulatory; Thiazolidinediones

2017
Downregulation of PI3K-γ in a mouse model of sepsis-induced myocardial dysfunction.
    Cytokine, 2017, Volume: 96

    Topics: Animals; Cardiomyopathies; Chromones; Class II Phosphatidylinositol 3-Kinases; Cytokines; Disease Models, Animal; Down-Regulation; Interleukin-6; Lipopolysaccharides; Mice; Morpholines; Myocardium; Quinoxalines; Sepsis; Signal Transduction; Thiazolidinediones; Tumor Necrosis Factor-alpha

2017
Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia.
    Journal of cellular physiology, 2018, Volume: 233, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Child; Child, Preschool; Class I Phosphatidylinositol 3-Kinases; Dexamethasone; Glucocorticoids; Heterocyclic Compounds, 3-Ring; Humans; Isoquinolines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Purines; Quinazolinones; Quinoxalines; Thiazolidinediones; Triazines

2018
Mechanisms underlying the antiproliferative effects of a series of quinoxaline-derived chalcones.
    Scientific reports, 2017, Nov-20, Volume: 7, Issue:1

    Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Chalcones; Class Ib Phosphatidylinositol 3-Kinase; Gene Expression Regulation, Neoplastic; Humans; Molecular Structure; Mouth Neoplasms; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Structure-Activity Relationship; Thiazolidinediones

2017
Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth.
    Circulation, 2018, 08-14, Volume: 138, Issue:7

    Topics: Animals; Antibiotics, Antineoplastic; Autophagy; Autophagy-Related Proteins; Breast Neoplasms; Cardiotoxicity; Class Ib Phosphatidylinositol 3-Kinase; Cytoprotection; Disease Models, Animal; Doxorubicin; Female; Genes, erbB-2; Heart Diseases; Mice, Inbred BALB C; Mice, Transgenic; Mutation; Myocytes, Cardiac; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinoxalines; Thiazolidinediones; Toll-Like Receptor 9; Tumor Burden

2018
Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis.
    Nature communications, 2018, 04-17, Volume: 9, Issue:1

    Topics: Adult; Animals; Biopsy; Cell Line; Chagas Cardiomyopathy; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Female; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myeloid Cells; Myocardium; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Signal Transduction; Thiazolidinediones; Trypanosoma cruzi; Up-Regulation

2018
A blockade of PI3Kγ signaling effectively mitigates angiotensin II-induced renal injury and fibrosis in a mouse model.
    Scientific reports, 2018, Jul-20, Volume: 8, Issue:1

    Topics: Angiotensin II; Animals; Cell Proliferation; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Fibroblasts; Fibrosis; Kidney; Mice; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Renal Insufficiency, Chronic; Thiazolidinediones

2018
PI3Kγ (Phosphoinositide 3-Kinase-γ) Inhibition Attenuates Tissue-Type Plasminogen Activator-Induced Brain Hemorrhage and Improves Microvascular Patency After Embolic Stroke.
    Hypertension (Dallas, Tex. : 1979), 2019, Volume: 73, Issue:1

    Topics: Animals; Blood-Brain Barrier; Cerebral Hemorrhage; Fibrinolytic Agents; Intracranial Embolism; Microvessels; Neuroprotective Agents; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Rats, Inbred SHR; Thiazolidinediones; Tissue Plasminogen Activator; Vascular Patency

2019
Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice.
    Neuropharmacology, 2019, Volume: 151

    Topics: Animals; Antineoplastic Agents, Phytogenic; Chemokine CXCL1; Ganglia, Spinal; Mice; Neurons; Paclitaxel; Peripheral Nervous System Diseases; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Quinoxalines; Receptors, Interleukin-8B; Signal Transduction; Spinal Cord; Thiazolidinediones

2019
Neutrophil Immunomodulatory Activity of Natural Organosulfur Compounds.
    Molecules (Basel, Switzerland), 2019, May-10, Volume: 24, Issue:9

    Topics: Allyl Compounds; Antioxidants; Disulfides; Garlic; Heterocyclic Compounds; HL-60 Cells; Humans; Immunologic Factors; Mitogen-Activated Protein Kinases; Neutrophils; Organic Chemicals; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Reactive Oxygen Species; Sulfides; Sulfur Compounds; Thiazolidinediones

2019
Inhibition of PI3Kγ by AS605240 Protects tMCAO Mice by Attenuating Pro-Inflammatory Signaling and Cytokine Release in Reactive Astrocytes.
    Neuroscience, 2019, 09-01, Volume: 415

    Topics: Animals; Astrocytes; Brain Ischemia; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappaB-Inducing Kinase; Protective Agents; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Stroke; Thiazolidinediones

2019
Converging TLR9 and PI3Kgamma signaling induces sterile inflammation and organ damage.
    Scientific reports, 2019, 12-13, Volume: 9, Issue:1

    Topics: Animals; Cell Survival; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Female; Gene Deletion; Inflammation; Liver; Lung; Mice, Inbred C57BL; Oligodeoxyribonucleotides; Organ Specificity; Pleura; Pulmonary Fibrosis; Quinoxalines; Signal Transduction; Silicon Dioxide; Thiazolidinediones; Toll-Like Receptor 9

2019
Inhibition of PI3Kγ by AS605240 plus low-dose tissue plasminogen activator (tPA) combination improves thrombolytic therapy in a rat model of embolic stroke.
    Neuroscience letters, 2020, 11-01, Volume: 738

    Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Embolic Stroke; Fibrinolytic Agents; Male; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome

2020
Phosphatidylinositol 3-kinase gamma participates in nimesulide-induced hepatic damage.
    The Journal of pharmacy and pharmacology, 2021, Mar-08, Volume: 73, Issue:4

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Free Radical Scavengers; Mice; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Sulfonamides; Thiazolidinediones; Treatment Outcome

2021