quinoxalines and as 605240

Topics: Animals; Arthritis, Rheumatoid; Humans; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

Topics: Animals; Disease Models, Animal; Enzyme Inhibitors; Female; Lupus Erythematosus, Systemic; Lupus Nephritis; Male; Mice; Mice, Mutant Strains; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

Topics: Animals; Arthritis, Rheumatoid; Binding Sites; Chemotaxis, Leukocyte; Dioxoles; Disease Models, Animal; Enzyme Inhibitors; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred DBA; Mice, Knockout; Molecular Sequence Data; Molecular Structure; Peritonitis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Thiazolidinediones

Topics: Animals; Arthritis; Autoimmune Diseases; Cell Line; Enzyme Activation; Enzyme Inhibitors; Isoenzymes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

Topics: Animals; Arthritis, Rheumatoid; Lupus Erythematosus, Systemic; Mice; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

Topics: Animals; Bacterial Proteins; Chemokine CCL2; Chemotaxis, Leukocyte; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Gene Deletion; Immunity, Innate; Isoenzymes; MAP Kinase Signaling System; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pneumonia, Pneumococcal; Quinoxalines; Streptolysins; Thiazolidinediones

Topics: Animals; Apolipoproteins E; Atherosclerosis; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Humans; Inflammation; Intramolecular Oxidoreductases; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphoinositide-3 Kinase Inhibitors; Prostaglandin-E Synthases; Quinoxalines; Receptors, LDL; Thiazolidinediones

Topics: Animals; Antigens; Cell Degranulation; Cell Movement; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Immunoglobulin E; Isoenzymes; Mast Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Receptors, IgE; Thiazolidinediones

Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Class Ib Phosphatidylinositol 3-Kinase; Concanavalin A; Cytokines; Enzyme Inhibitors; Isoenzymes; Liver; Liver Cirrhosis; Mice; Mitogens; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones

Topics: Actins; Animals; Calcium Channels; Cell Line, Tumor; Class Ib Phosphatidylinositol 3-Kinase; Exocytosis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Isoenzymes; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pancreatic Neoplasms; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; RNA, Small Interfering; Secretory Vesicles; Thiazolidinediones

Topics: Acute Lung Injury; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Chimera; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Lipopolysaccharides; Lung; Male; Membrane Proteins; Mice; Neutrophils; Phosphatidylinositol 3-Kinases; Quinoxalines; Thiazolidinediones

Topics: Acute Disease; Animals; Blotting, Western; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Flow Cytometry; Fluorescent Antibody Technique; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Organ Size; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Severity of Illness Index; Spleen; Thiazolidinediones

Topics: Animals; Antibodies, Antineutrophil Cytoplasmic; Cell Adhesion; Cell Degranulation; Cell Movement; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Female; Glomerulonephritis; Humans; Isoenzymes; Macrophages; Male; Mice; Mice, Inbred C57BL; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Reactive Oxygen Species; Thiazolidinediones

Topics: Animals; Autoimmune Diseases; Chemokine CCL2; Class Ib Phosphatidylinositol 3-Kinase; Down-Regulation; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Myocarditis; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Random Allocation; Thiazolidinediones; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Chromones; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Humans; Inflammation; Leukocytes; Male; Mice; Morpholines; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Recovery of Function; Regeneration; RNA Interference; Signal Transduction; Thiazolidinediones; Time Factors; Transfection; Ventricular Function, Left

Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, SCID; Neuroblastoma; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; Thiazolidinediones; Tumor Burden; Xenograft Model Antitumor Assays

Topics: Animals; Bleomycin; Enzyme Inhibitors; Female; Phosphoinositide-3 Kinase Inhibitors; Pulmonary Fibrosis; Quinoxalines; Rats; Rats, Sprague-Dawley; Thiazolidinediones

Topics: Animals; Cardiovascular Agents; Disease Models, Animal; Genotype; Mice; Mice, Knockout; Myocardial Infarction; Myocardium; Neovascularization, Physiologic; Phenotype; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinoxalines; Thiazolidinediones; Ventricular Function, Left; Ventricular Remodeling

Topics: Acquired Immunodeficiency Syndrome; Androstadienes; Animals; Antigens, CD; Cadherins; Capillary Permeability; Cell Line; Chromones; Cinnamates; Endothelial Cells; Enzyme Inhibitors; Female; Furans; Herpesvirus 8, Human; Humans; Indoles; Intercellular Junctions; Mice; Mice, Nude; Morpholines; Phosphatidylinositol 3-Kinases; Pyridines; Pyrimidines; Quinoxalines; Receptors, Chemokine; RNA, Small Interfering; Sarcoma, Kaposi; Skin; Skin Neoplasms; Sulfonamides; Thiazolidinediones; Wortmannin

Topics: Cell Proliferation; Cells, Cultured; Chromones; Fibroblast Growth Factor 2; Flavonoids; Histocompatibility Antigens Class II; HLA-DR Antigens; Humans; Interferon-gamma; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones; Trans-Activators

Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Male; Mice; Mice, Inbred ICR; Myocardial Infarction; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones; Ventricular Remodeling

Topics: Animals; Apoptosis; CD4 Antigens; Cells, Cultured; Colitis; Colon; Cytokines; Forkhead Transcription Factors; Interleukin-2 Receptor alpha Subunit; Intestinal Mucosa; Male; Matrix Metalloproteinase 9; Mice; Neutrophil Infiltration; Neutrophils; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; T-Lymphocytes, Regulatory; Thiazolidinediones; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A

Topics: Acylation; Adipocytes; Adrenergic beta-Agonists; Animals; Benzimidazoles; Blotting, Western; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Interactions; Ghrelin; Glycerol; Intra-Abdominal Fat; Isoproterenol; Lipolysis; Male; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; Quinoxalines; Rats; Rats, Wistar; Thiazolidinediones

Topics: Adipose Tissue; Animals; Class Ib Phosphatidylinositol 3-Kinase; Flow Cytometry; Gene Expression Profiling; Histological Techniques; Inflammation; Insulin Resistance; Liver; Macrophages; Mice; Mice, Knockout; Obesity; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

Topics: A Kinase Anchor Proteins; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Class Ib Phosphatidylinositol 3-Kinase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase RIIalpha Subunit; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; DNA; Enzyme Activation; Enzyme Inhibitors; Heart Failure; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Myocytes, Cardiac; Peptide Fragments; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Interaction Mapping; Quinoxalines; Receptors, Adrenergic, beta; Second Messenger Systems; Sequence Homology, Amino Acid; Thiazolidinediones

Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Aorta; Cell Movement; Cell Transplantation; Embryo, Nonmammalian; Endothelial Cells; Endothelium; Gene Expression Regulation, Developmental; In Vitro Techniques; Indoles; Luminescent Proteins; Molecular Sequence Data; Neovascularization, Physiologic; Oligodeoxyribonucleotides, Antisense; Pyrroles; Quinoxalines; Receptors, Cell Surface; Receptors, Notch; RNA, Messenger; Semaphorins; Signal Transduction; Thiazolidinediones; Vascular Endothelial Growth Factor Receptor-1; Zebrafish; Zebrafish Proteins

Topics: Animals; Cardiomegaly; Fibrosis; Isoproterenol; Male; Myocardium; Proteasome Endopeptidase Complex; Proteins; Quinoxalines; Random Allocation; Rats; Rats, Wistar; Thiazolidinediones

Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Inflammation; Injections, Intraventricular; Male; Mice; Neural Inhibition; Neuralgia; Neuritis; Nociception; Phosphoinositide-3 Kinase Inhibitors; Pruritus; Quinoxalines; Thiazolidinediones; Trypsin

Topics: Analysis of Variance; Animals; Behavior, Animal; Biophysics; Chromones; Class Ib Phosphatidylinositol 3-Kinase; Conditioning, Classical; Electric Stimulation; Environment; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Exploratory Behavior; Extinction, Psychological; Fear; Female; Gene Expression Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Male; Maze Learning; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Neurons; Oncogene Protein v-akt; Phosphorylation; Quinoxalines; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Thiazolidinediones; Time Factors

Topics: Animals; Blood Pressure; Calcium Channels, L-Type; Calcium Signaling; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Hypertension; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Thiazolidinediones; Vasodilation

Topics: Animals; Cell Differentiation; Cholesterol, LDL; Class Ib Phosphatidylinositol 3-Kinase; Foam Cells; Granulocyte-Macrophage Colony-Stimulating Factor; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Pinocytosis; Quinoxalines; Thiazolidinediones

Topics: Acute Lung Injury; Animals; Cell Nucleus; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Dendritic Cells; Enzyme Activation; Female; I-kappa B Proteins; Immunity, Innate; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; NF-KappaB Inhibitor alpha; Peroxidase; Phosphoinositide-3 Kinase Inhibitors; Protein Transport; Quinoxalines; Reactive Oxygen Species; Signal Transduction; Thiazolidinediones; Toll-Like Receptor 4; Vascular Endothelial Growth Factor A

Topics: Animals; Antimony Sodium Gluconate; Disease Resistance; Flow Cytometry; Host-Parasite Interactions; Humans; Leishmania mexicana; Leishmaniasis, Cutaneous; Macrophages; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neutrophils; Phagocytes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Thiazolidinediones

Topics: Animals; Diabetes Mellitus, Type 1; Female; Hyperglycemia; Mice; Mice, Inbred NOD; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Spleen; T-Lymphocytes, Regulatory; Thiazolidinediones

Topics: Cell Line; Cell Line, Tumor; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Epithelial Cells; Humans; Hydrogen Peroxide; Lipopolysaccharides; Lung; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Reactive Oxygen Species; RNA, Small Interfering; Thiazolidinediones

Topics: Administration, Oral; Animals; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Movement; Cell Survival; Central Nervous System; Class Ib Phosphatidylinositol 3-Kinase; Cross-Priming; Cytokines; Dendritic Cells; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Deletion; Humans; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Quinoxalines; Signal Transduction; Th1 Cells; Th17 Cells; Thiazolidinediones

Topics: Chemokine CCL11; Chemotaxis; Class Ib Phosphatidylinositol 3-Kinase; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Eosinophil-Derived Neurotoxin; Eosinophils; Flow Cytometry; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Thiazolidinediones

Topics: Adipogenesis; Cells, Cultured; Chromones; Drug Discovery; Gene Expression Regulation; Graves Ophthalmopathy; Humans; Hyaluronic Acid; Molecular Targeted Therapy; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinoxalines; Receptor, IGF Type 1; Receptors, Thyrotropin; Signal Transduction; Thiazolidinediones

Topics: Adenosine; Animals; Antibodies, Antinuclear; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cells, Cultured; Class I Phosphatidylinositol 3-Kinases; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Dose-Response Relationship, Drug; Flow Cytometry; Immunoglobulin G; Kidney; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphocyte Count; Macrophages; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Microscopy, Confocal; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinazolinones; Quinoxalines; Survival Analysis; Thiazolidinediones

Topics: Animals; Carotid Artery Injuries; Class Ib Phosphatidylinositol 3-Kinase; Enzyme Inhibitors; Femoral Artery; Gene Targeting; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neointima; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Th1 Cells; Thiazolidinediones

Topics: Animals; Calcium; Calcium-Binding Proteins; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Doublecortin Domain Proteins; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Microtubule-Associated Proteins; Muscarinic Agonists; Neuropeptides; Pilocarpine; Prefrontal Cortex; Quinoxalines; Reaction Time; Seizures; Synaptosomes; Thiazolidinediones; Time Factors

Topics: Animals; Brain; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Extracellular Matrix; Female; Humans; Lung; Malaria, Cerebral; Mice; Phosphoinositide-3 Kinase Inhibitors; Plasmodium berghei; Quinoxalines; Survival Analysis; Thiazolidinediones

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Interactions; Drug Resistance, Neoplasm; Drug Synergism; Glucocorticoids; Humans; Methotrexate; Mice; Mice, Inbred NOD; Mice, SCID; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein Kinase Inhibitors; Quinoxalines; Random Allocation; Signal Transduction; Thiazolidinediones; Xenograft Model Antitumor Assays

Topics: Androstadienes; Animals; Cell Differentiation; Cell Line; Humans; Hydrazones; Lung; Male; Mice, Inbred ICR; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Pulmonary Alveoli; Pulmonary Disease, Chronic Obstructive; Quinoxalines; Regeneration; Stem Cells; Sulfonamides; Thiazolidinediones; Wortmannin

Topics: Action Potentials; Animals; Anticarcinogenic Agents; Bombesin; Capsaicin; Central Nervous System; Disease Models, Animal; Enzyme Inhibitors; Ganglia, Spinal; Gastrin-Releasing Peptide; Indoles; Male; Mice; Neurons; p-Methoxy-N-methylphenethylamine; Pain Threshold; Peptide Fragments; Phosphatidylinositol 3-Kinase; Pruritus; Quinoxalines; Reaction Time; Receptors, Bombesin; Synaptic Transmission; Thiazolidinediones

Topics: Androstadienes; Animals; Capillary Leak Syndrome; Capillary Permeability; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Endothelium, Vascular; Enzyme Activation; Enzyme Induction; Forkhead Box Protein M1; Forkhead Transcription Factors; Furans; Humans; Lung; Mice; Mice, Knockout; Microvessels; Neutrophils; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Pulmonary Edema; Pyridines; Pyrimidines; Quinoxalines; Recombinant Fusion Proteins; Regeneration; Respiratory Distress Syndrome; Sepsis; Signal Transduction; Thiazolidinediones; Transfection; Wortmannin

Topics: Animals; CD4-Positive T-Lymphocytes; Cell Proliferation; Cell Survival; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Humans; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Pancreas; Peptides; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; T-Lymphocytes, Regulatory; Thiazolidinediones

Topics: Animals; Cardiomyopathies; Chromones; Class II Phosphatidylinositol 3-Kinases; Cytokines; Disease Models, Animal; Down-Regulation; Interleukin-6; Lipopolysaccharides; Mice; Morpholines; Myocardium; Quinoxalines; Sepsis; Signal Transduction; Thiazolidinediones; Tumor Necrosis Factor-alpha

Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Child; Child, Preschool; Class I Phosphatidylinositol 3-Kinases; Dexamethasone; Glucocorticoids; Heterocyclic Compounds, 3-Ring; Humans; Isoquinolines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Purines; Quinazolinones; Quinoxalines; Thiazolidinediones; Triazines

Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Chalcones; Class Ib Phosphatidylinositol 3-Kinase; Gene Expression Regulation, Neoplastic; Humans; Molecular Structure; Mouth Neoplasms; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Structure-Activity Relationship; Thiazolidinediones

Topics: Animals; Antibiotics, Antineoplastic; Autophagy; Autophagy-Related Proteins; Breast Neoplasms; Cardiotoxicity; Class Ib Phosphatidylinositol 3-Kinase; Cytoprotection; Disease Models, Animal; Doxorubicin; Female; Genes, erbB-2; Heart Diseases; Mice, Inbred BALB C; Mice, Transgenic; Mutation; Myocytes, Cardiac; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Quinoxalines; Thiazolidinediones; Toll-Like Receptor 9; Tumor Burden

Topics: Adult; Animals; Biopsy; Cell Line; Chagas Cardiomyopathy; Class Ib Phosphatidylinositol 3-Kinase; Disease Models, Animal; Female; Heart; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Myeloid Cells; Myocardium; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Signal Transduction; Thiazolidinediones; Trypanosoma cruzi; Up-Regulation

Topics: Angiotensin II; Animals; Cell Proliferation; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Fibroblasts; Fibrosis; Kidney; Mice; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Renal Insufficiency, Chronic; Thiazolidinediones

Topics: Animals; Blood-Brain Barrier; Cerebral Hemorrhage; Fibrinolytic Agents; Intracranial Embolism; Microvessels; Neuroprotective Agents; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Rats, Inbred SHR; Thiazolidinediones; Tissue Plasminogen Activator; Vascular Patency

Topics: Animals; Antineoplastic Agents, Phytogenic; Chemokine CXCL1; Ganglia, Spinal; Mice; Neurons; Paclitaxel; Peripheral Nervous System Diseases; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Quinoxalines; Receptors, Interleukin-8B; Signal Transduction; Spinal Cord; Thiazolidinediones

Topics: Allyl Compounds; Antioxidants; Disulfides; Garlic; Heterocyclic Compounds; HL-60 Cells; Humans; Immunologic Factors; Mitogen-Activated Protein Kinases; Neutrophils; Organic Chemicals; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinoxalines; Reactive Oxygen Species; Sulfides; Sulfur Compounds; Thiazolidinediones

Topics: Animals; Astrocytes; Brain Ischemia; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Disease Models, Animal; Infarction, Middle Cerebral Artery; Inflammation; Male; Mice; Mice, Inbred C57BL; NF-kappaB-Inducing Kinase; Protective Agents; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Stroke; Thiazolidinediones

Topics: Animals; Cell Survival; Class Ib Phosphatidylinositol 3-Kinase; Cytokines; Female; Gene Deletion; Inflammation; Liver; Lung; Mice, Inbred C57BL; Oligodeoxyribonucleotides; Organ Specificity; Pleura; Pulmonary Fibrosis; Quinoxalines; Signal Transduction; Silicon Dioxide; Thiazolidinediones; Toll-Like Receptor 9

Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Embolic Stroke; Fibrinolytic Agents; Male; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Thrombolytic Therapy; Tissue Plasminogen Activator; Treatment Outcome

Topics: Animals; Chemical and Drug Induced Liver Injury; Cyclooxygenase Inhibitors; Dimethyl Sulfoxide; Free Radical Scavengers; Mice; NF-kappa B; Oxidative Stress; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; Sulfonamides; Thiazolidinediones; Treatment Outcome