quinoxalines has been researched along with alanine in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (13.51) | 18.7374 |
| 1990's | 19 (51.35) | 18.2507 |
| 2000's | 9 (24.32) | 29.6817 |
| 2010's | 3 (8.11) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Johnston, MV; McDonald, JW | 1 |
| Hayashi, M; Hirose, E; Ito, I; Kohda, A; Mitsunaga, S; Sugiyama, H; Tanabe, S | 1 |
| Felton, JS; Jägerstad, M; Knize, MG; Skog, K | 1 |
| Clifford, DB; Thio, LL; Zorumski, CF | 1 |
| Bockaert, J; Do, E; Manzoni, OJ; Poulat, F; Sahuquet, A; Sassetti, I; Sladeczek, FA | 1 |
| Ito, I; Sugiyama, H | 1 |
| Grivas, S; Jägerstad, M; Nyhammar, T; Olsson, K | 2 |
| Arif, AJ; Bhaduri, AP; Dhar, MM; Gupta, CM; Khan, AW; Singh, C | 1 |
| Barz, W; Stadtman, ER | 1 |
| Gerchakov, S; Schultz, HP | 1 |
| Bernardi, G; Bonci, A; Calabresi, P; Mercuri, NB; Stratta, F | 1 |
| Beaver, KM; Hawkins, LM; Jane, DE; Roberts, PJ; Sunter, DC; Taylor, PM | 1 |
| Honoré, T; Sheardown, MJ; Suzdak, PD | 1 |
| Fukunaga, K; Miyamoto, E; Ushio, Y; Yano, S | 1 |
| Goldstein, DS; Kopin, IJ; Pacak, K; Yadid, G | 1 |
| Black, IB; Dreyfus, CF; Mount, HT | 1 |
| Averill, DB; Tsuchihashi, T | 1 |
| Cardoso, LF; Martini, LH; Souza, DO; Tasca, CI; Vendite, D | 1 |
| Fleischer-Lambropoulos, E; Geladopoulos, T; Kazazoglou, T; Kentroti, S; Stefanis, C; Vernadakis, A | 1 |
| Ebert, B; Krogsgaard-Larsen, P; Madsen, U; Søby, KK | 1 |
| Glitsch, M; Llano, I; Marty, A | 1 |
| Itoh, Y; Kimura, K; Oka, M; Shimidzu, T; Ukai, Y; Yoshikuni, Y | 1 |
| Cossu, M; Fedele, E; Fontana, G; Munari, C; Raiteri, M | 1 |
| Randich, A; Turnbach, ME | 1 |
| Jane, DE; More, JC; Troop, HM | 1 |
| Gouaux, E; Jin, R | 1 |
| Callewaert, G; Leyssen, M; Robberecht, W; Van Damme, P; Van Den Bosch, L | 1 |
| Rothkegel, C; Schmidt, PM; Schröder, H; Stasch, JP; Wunder, F | 1 |
| Carta, M; Mameli, M; Valenzuela, CF | 1 |
| Dolman, NP; Ghosal, A; Jane, DE; Mayer, ML | 1 |
| Yonehara, N; Yoshimura, M | 1 |
| Blaabjerg, M; Kristensen, BW; Noraberg, J; Zimmer, J | 1 |
| Kallinen, SA; Kontturi, LS; Salonen, V; Uusi-Oukari, M | 1 |
| Gardner, PD; Hendrickson, LM; Pang, X; Tapper, AR; Zhao-Shea, R | 1 |
| Bough, R; Dayan, FE | 1 |
37 other study(ies) available for quinoxalines and alanine
| Article | Year |
|---|---|
Neuroprotective synergism of 2-amino-3-phosphonoproprionate (D,L-AP3) and MK-801 against ibotenate induced brain injury.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Brain; Brain Diseases; Dizocilpine Maleate; Drug Synergism; Female; Ibotenic Acid; Injections; Male; Organ Size; Quinoxalines; Rats; Rats, Sprague-Dawley | 1992 |
3,5-Dihydroxyphenyl-glycine: a potent agonist of metabotropic glutamate receptors.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Cycloleucine; Egtazic Acid; Glycine; Hippocampus; In Vitro Techniques; Male; Oocytes; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Resorcinols; RNA, Messenger; Xenopus | 1992 |
Formation of new heterocyclic amine mutagens by heating creatinine, alanine, threonine and glucose.
Topics: Alanine; Amines; Amino Acids; Chromatography, High Pressure Liquid; Cooking; Creatinine; Glucose; Heterocyclic Compounds; Hot Temperature; Magnetic Resonance Spectroscopy; Maillard Reaction; Mass Spectrometry; Meat; Mutagenicity Tests; Mutagens; Quinoxalines; Salmonella typhimurium; Threonine | 1992 |
Effects of bromowillardiine and willardiine on non-N-methyl-D-aspartate receptors in postnatal rat hippocampal neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hippocampus; Membrane Potentials; Neurons; Pyrimidinones; Quinoxalines; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Uracil | 1991 |
Pharmacological characterization of the quisqualate receptor coupled to phospholipase C (Qp) in striatal neurons.
Topics: 2-Aminoadipic Acid; 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Aminobutyrates; Animals; Cells, Cultured; Corpus Striatum; Dizocilpine Maleate; Fura-2; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Phorbol 12,13-Dibutyrate; Phosphoserine; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Type C Phospholipases | 1991 |
Roles of glutamate receptors in long-term potentiation at hippocampal mossy fiber synapses.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Evoked Potentials; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Perfusion; Pyramidal Tracts; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1991 |
Formation of 4,8-DiMeIQx from the model system fructose, alanine and creatinine. Comparison with the isomeric 5,8-DiMeIQx.
Topics: Alanine; Chromatography, High Pressure Liquid; Creatinine; Fructose; Isomerism; Magnetic Resonance Spectroscopy; Mutagens; Quinoxalines; Structure-Activity Relationship | 1986 |
Formation of a new mutagenic DiMeIQx compound in a model system by heating creatinine, alanine and fructose.
Topics: Alanine; Creatinine; Fructose; Hot Temperature; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mutagens; Quinoxalines; Spectrophotometry, Ultraviolet | 1985 |
Actinomycetes studies. II. Cell-free synthesis of echinomycin and an echinomycin analogue.
Topics: Acetates; Adenosine Triphosphate; Alanine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carboxylic Acids; Cell-Free System; Dialysis; Magnesium; Mercaptoethanol; Microbial Sensitivity Tests; Quinazolines; Quinoxalines; Rats; Staphylococcus; Stimulation, Chemical; Streptomyces | 1970 |
Bacterial degradation of riboflavin. VII. Studies on the bacterial decomposition of 6,7-dimethylquinoxaline-2,3-diol.
Topics: Acetates; Alanine; Amino Acids; Butyrates; Carbon Dioxide; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gas; Densitometry; Freeze Drying; Oxygen; Propionates; Pseudomonas; Pyrans; Quinoxalines; Riboflavin; Spectrophotometry | 1969 |
Quinoxaline studies. XIV. Potential anticancer agents. Some quinoxaline amino acid and dipeptide derivatives related to quinoxaline antibiotics.
Topics: Alanine; Amino Acids; Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Dipeptides; Glycine; Leukemia L1210; Methionine; Mice; Quinoxalines; Serine; Valine | 1969 |
Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dopamine; Electrophysiology; Female; Glycine; Male; Neurons; Potassium; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Tetrodotoxin | 1993 |
Binding of the new radioligand (S)-[3H]AMPA to rat brain synaptic membranes: effects of a series of structural analogues of the non-NMDA receptor agonist willardiine.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Cycloleucine; Male; Pyrimidinones; Quinoxalines; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Stereoisomerism; Synaptic Membranes; Tritium; Uracil | 1995 |
Characterization of the metabotropic glutamate receptor in mouse cerebellar granule cells: lack of effect of 2,3-dihydroxy-6-nitro-7-sulphamoylbenzo(F)-quinoxaline (NBQX).
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; GTP-Binding Proteins; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Mice; Neurons; Pertussis Toxin; Phosphatidylinositols; Quinoxalines; Quisqualic Acid; Receptors, Glutamate; Virulence Factors, Bordetella | 1993 |
Activation of Ca2+/calmodulin-dependent protein kinase II and phosphorylation of intermediate filament proteins by stimulation of glutamate receptors in cultured rat cortical astrocytes.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; Animals; Animals, Newborn; Astrocytes; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Glutamates; Glutamic Acid; Immunoblotting; Ionomycin; Molecular Weight; Phosphoproteins; Phosphorylation; Quinoxalines; Rats; Rats, Wistar; Receptors, Glutamate; Tetradecanoylphorbol Acetate; Vimentin | 1994 |
Endogenous serotonin stimulates striatal dopamine release in conscious rats.
Topics: 5,7-Dihydroxytryptamine; Alanine; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Male; Microdialysis; Perfusion; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Receptor Agonists | 1994 |
Purkinje cell survival is differentially regulated by metabotropic and ionotropic excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Cell Survival; Cells, Cultured; Cyclopentanes; Dizocilpine Maleate; Embryo, Mammalian; gamma-Aminobutyric Acid; Kinetics; Purkinje Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
Metabotropic glutamate receptors in the ventrolateral medulla of rats.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Amino Acids; Animals; Blood Pressure; Cycloleucine; Dose-Response Relationship, Drug; Drug Combinations; Male; Medulla Oblongata; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stimulation, Chemical | 1993 |
Modulation of adenosine-induced cAMP accumulation via metabotropic glutamate receptors in chick optic tectum.
Topics: Adenosine; Alanine; Animals; Benzoates; Chickens; Cyclic AMP; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Quinoxalines; Receptors, Metabotropic Glutamate; Superior Colliculi | 1995 |
Stimulation of glutamine synthetase activity by excitatory amino acids in astrocyte cultures derived from aged mouse cerebral hemispheres may be associated with non-N-methyl-D-aspartate receptor activation.
Topics: 2-Amino-5-phosphonovalerate; Aging; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Cell Division; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamate-Ammonia Ligase; Glutamic Acid; Mice; N-Methylaspartate; Neurotoxins; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 1996 |
Functional partial agonism at ionotropic excitatory amino acid receptors.
Topics: Alanine; Animals; Binding, Competitive; Cerebral Cortex; Dinucleoside Phosphates; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Models, Neurological; N-Methylaspartate; Propionates; Quinoxalines; Rats; Receptors, AMPA; Receptors, Glutamate | 1996 |
Glutamate as a candidate retrograde messenger at interneurone-Purkinje cell synapses of rat cerebellum.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Benzoates; Colforsin; Cyclopropanes; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Interneurons; Kinetics; Presynaptic Terminals; Purkinje Cells; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Tetrodotoxin | 1996 |
Involvement of metabotropic glutamate receptors in Gi- and Gs-dependent modulation of adenylate cyclase activity induced by a novel cognition enhancer NS-105 in rat brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adrenergic alpha-Agonists; Alanine; Animals; Baclofen; Brimonidine Tartrate; Cell Membrane; Cerebral Cortex; Cholera Toxin; Cognition; Colforsin; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Isoproterenol; Kinetics; Male; Manganese; Pertussis Toxin; Piperidines; Proline; Quinoxalines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Neurotransmitter; Virulence Factors, Bordetella; Yohimbine | 1997 |
Activation of brain nitric oxide synthase in depolarized human temporal cortex slices: differential role of voltage-sensitive calcium channels.
Topics: Alanine; Arginine; Calcium Channel Blockers; Calcium Channels; Citrulline; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; In Vitro Techniques; Mecamylamine; Nicotinic Antagonists; Nitric Oxide Synthase; Nitroarginine; Potassium; Potassium Chloride; Quinoxalines; Temporal Lobe | 1997 |
The role of spinal neurokinin-1 and glutamate receptors in hyperalgesia and allodynia induced by prostaglandin E(2) or zymosan in the rat.
Topics: 2-Amino-5-phosphonovalerate; Alanine; Animals; Dinoprostone; Excitatory Amino Acid Antagonists; Hyperalgesia; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Zymosan | 2002 |
The novel antagonist 3-CBW discriminates between kainate receptors expressed on neonatal rat motoneurones and those on dorsal root C-fibres.
Topics: Alanine; Animals; Animals, Newborn; Benzodiazepines; Benzyl Compounds; Dose-Response Relationship, Drug; Evoked Potentials; Excitatory Amino Acid Antagonists; Motor Neurons; Nerve Fibers; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Spinal Nerve Roots; Time Factors; Uracil | 2002 |
Probing the function, conformational plasticity, and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardiines and GluR2 S1S2 in the crystal.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Dimerization; Excitatory Amino Acid Agonists; Kainic Acid; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Uracil | 2003 |
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis.
Topics: Age Factors; Alanine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Behavior, Animal; Calcium; Cells, Cultured; Disease Models, Animal; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Forelimb; Glycine; Hand Strength; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Motor Neurons; Psychomotor Performance; Quinoxalines; Receptors, AMPA | 2003 |
Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase.
Topics: Alanine; Amino Acid Sequence; Amino Acid Substitution; Animals; Benzoates; Binding Sites; CHO Cells; Cricetinae; Cricetulus; Cyclic GMP; Diethylamines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genotype; Guanylate Cyclase; Heme; Molecular Sequence Data; Mutation, Missense; Nitric Acid; Nitrogen Oxides; Oxadiazoles; Protoporphyrins; Pyrazoles; Pyridines; Quinoxalines; Sequence Homology, Amino Acid; Serine; Solubility; Transfection | 2005 |
Alcohol potently modulates climbing fiber-->Purkinje neuron synapses: role of metabotropic glutamate receptors.
Topics: Alanine; Animals; Aspartic Acid; Disease Models, Animal; Ethanol; Long-Term Synaptic Depression; Male; Nerve Fibers; Patch-Clamp Techniques; Purkinje Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Xanthenes | 2006 |
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Crystallography, X-Ray; Excitatory Amino Acid Antagonists; GluK2 Kainate Receptor; Glutamic Acid; Hydrogen Bonding; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Binding; Protein Conformation; Quinoxalines; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Thymine; Xenopus laevis | 2006 |
Alteration in sensitivity of ionotropic glutamate receptors and tachykinin receptors in spinal cord contribute to development and maintenance of nerve injury-evoked neuropathic pain.
Topics: Alanine; Analgesics; Animals; Behavior, Animal; Benzamides; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Indoles; Isoindoles; Male; N-Methylaspartate; Pain; Pain Measurement; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Tachykinin; Sciatic Nerve; Spinal Cord; Substance P; Valine | 2006 |
Long-term, repeated dose in vitro neurotoxicity of the glutamate receptor antagonist L-AP3, demonstrated in rat hippocampal slice cultures by using continuous propidium iodide incubation.
Topics: Alanine; Animal Testing Alternatives; Animals; Coloring Agents; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; L-Lactate Dehydrogenase; Propidium; Quinoxalines; Rats; Staining and Labeling; Tissue Culture Techniques | 2007 |
AMPA receptors serum-dependently mediate GABAA receptor alpha1 and alpha6 subunit down-regulation in cultured mouse cerebellar granule cells.
Topics: Alanine; Animals; Cells, Cultured; Cerebellum; Coloring Agents; Culture Media, Serum-Free; Down-Regulation; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; GluK2 Kainate Receptor; Kainic Acid; Mice; Neurons; Protein Binding; Pyrimidinones; Quinoxalines; Receptors, AMPA; Receptors, GABA-A; Receptors, Kainic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2010 |
Activation of alpha4* nAChRs is necessary and sufficient for varenicline-induced reduction of alcohol consumption.
Topics: Alanine; Alcohol Drinking; Analysis of Variance; Animals; Benzazepines; Central Nervous System Depressants; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drinking Behavior; Drug Combinations; Ethanol; Gene Expression Regulation; Leucine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurons; Nicotinic Agonists; Proto-Oncogene Proteins c-fos; Quinoxalines; Receptors, Nicotinic; Tyrosine 3-Monooxygenase; Varenicline; Ventral Tegmental Area | 2010 |
Public health round-up.
Topics: Adenosine Monophosphate; Alanine; Aminoisobutyric Acids; Anti-Bacterial Agents; Antibodies, Monoclonal; Benzimidazoles; Cyclopropanes; Democratic Republic of the Congo; Disease Outbreaks; Drug Resistance, Bacterial; Global Health; Hemorrhagic Fever, Ebola; Hepatitis C; Humans; Interinstitutional Relations; Lactams, Macrocyclic; Leucine; Malaria; Measles; Measles Vaccine; Poliomyelitis; Proline; Public Health Practice; Pyrrolidines; Quinoxalines; Randomized Controlled Trials as Topic; Ribonucleotides; Sulfonamides; Tuberculosis | 2019 |
Biochemical and structural characterization of quizalofop-resistant wheat acetyl-CoA carboxylase.
Topics: Acetyl-CoA Carboxylase; Acetyltransferases; Alanine; Amino Acid Substitution; Herbicide Resistance; Herbicides; Mutation; Plant Proteins; Poaceae; Propionates; Pyridines; Quinoxalines; Triticum; Valine | 2022 |