quinoxalines has been researched along with akt-i-1,2 compound in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (27.27) | 29.6817 |
| 2010's | 21 (63.64) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Balitza, AE; Barnett, SF; Bilodeau, MT; Defeo-Jones, D; Hartman, GD; Haskell, K; Hoffman, JM; Huber, HE; Jones, RE; Leander, K; Manley, PJ; Robinson, RG; Smith, AM | 1 |
| Barnett, SF; Defeo-Jones, D; Fu, S; Hancock, PJ; Haskell, KM; Huber, HE; Jones, RE; Kahana, JA; Kral, AM; Leander, K; Lee, LL; Malinowski, J; McAvoy, EM; Nahas, DD; Robinson, RG | 1 |
| Holt, B; Kane, LP; Narayan, P; Tosti, R | 1 |
| Alessi, DR; Bain, J; Keane, M; Logie, L; Marquez, R; Ruiz-Alcaraz, AJ; Sutherland, C; Woods, YL | 1 |
| Chua, BH; Chua, CC; Chua, KW; Gao, J; Hamdy, RC; Wang, H; Xu, X | 1 |
| Hu, C; Lee, H; Solomon, VR; Ulibarri, G | 1 |
| Harper, MT; Hers, I; Hunter, RW | 1 |
| Davis, DP; De Mazière, A; Degtyarev, M; Friedman, LS; Gray, DC; Hoeflich, KP; Klumperman, J; Lee, BB; Lin, J; Lin, K; Murray, LJ; Orr, C; Prior, WW; Stern, HM; Tien, JY; van Dijk, S; Wu, H | 1 |
| Coll-Mulet, L; Cosialls, AM; de Frias, M; de la Banda, E; Gil, J; González-Gironès, DM; Iglesias-Serret, D; Pons, G; Santidrián, AF | 1 |
| Buontempo, F; Capitani, S; Cetin-Atalay, R; Ersahin, T; Etro, D; Missiroli, S; Neri, ML; Ozturk, M; Senturk, S | 1 |
| Mansley, MK; Wilson, SM | 1 |
| Baselga, J; Chandarlapaty, S; Grbovic-Huezo, O; Majumder, PK; Rodrik-Outmezguine, V; Rosen, N; Sawai, A; Scaltriti, M; Serra, V | 1 |
| Arnoletti, E; Baragli, A; Ghè, C; Ghigo, E; Granata, R; Muccioli, G | 1 |
| Romano-Silva, MA; Souza, BR; Tropepe, V | 1 |
| Dorigo, O; Eng, C; Fekete, M; Santiskulvong, C | 1 |
| Jhiang, SM; Liu, YY; Ringel, MD; Zhang, X | 1 |
| Donaldson, DS; Gally, DL; Gillespie, TL; Haas, J; Lengeling, A; Mabbott, NA; Mahajan, A; Mahajan, S; Malterer, G; O'Shea, M; Paxton, E; Roe, AJ; Shaw, DJ; Tahoun, A; Tan, A; Wang, D | 1 |
| Kumar, A; Purohit, R | 1 |
| Bertrand, M; Correa, RJ; DiMattia, GE; Fazio, EN; McGee, J; Peart, TM; Préfontaine, M; Shepherd, TG; Sugimoto, A; Valdes, YR | 1 |
| Dolstra, H; Falkenburg, JH; Gattinoni, L; Hobo, W; Jansen, JH; Kester, MG; Kramer, CS; Maas, F; Schaap, N; van de Weem, NM; van der Voort, R; van der Waart, AB | 1 |
| Albrecht, T; Alejandro, EU; Chan, MT; Hoesli, CA; Johnson, JD; Lim, GE; Piret, JM; Skovsø, S; Warnock, GL; Yang, YH | 1 |
| Cheng, J; He, JQ; Kang, B; Li, WX; Tong, Y; Wang, YJ; Yang, Y; Yao, HP; Yin, SY; Zhang, XQ; Zhao, QW; Zheng, M; Zhou, YW | 1 |
| Danish, S; Haffty, BG; Khan, A; Mehta, M; Sabaawy, HE | 1 |
| Kato, H; Morishita, S; Murakoshi, M; Nishino, H; Ono, T; Saito, K; Sugiyama, K; Tomita, K | 1 |
| Choi, Y; Ishii, M; Kanagawa, O; Kim, H; Miyawaki, A; Mizuno, H; Sakaue-Sawano, A; Takegahara, N; Tomura, M | 1 |
| Jiang, Q; Qu, Z; Yang, M; Zhang, Q; Zhou, J | 1 |
| Barnett, TC; Liebl, D; Qi, X; Teasdale, RD; Zhe, Y | 1 |
| Haniuda, M; Hosokawa, Y; Hyodo, T; Karnan, S; Konishi, H; Ota, A; Tsuzuki, S; Wahiduzzaman, M; Yamaji, M | 1 |
| Alfano, L; Barone, D; Costa, C; Esposito, L; Forte, IM; Giordano, A; Iannuzzi, CA; Indovina, P; Pentimalli, F; Rocco, G | 1 |
| Bjune, K; Naderi, S; Wierød, L | 1 |
| Bowen, JP; Güner, OF; Matesic, DF; Uko, NE | 1 |
| Chuang, SJ; Hussain, N; Johanns, M; Kemp, BE; Rider, MH; Steinberg, GR; Vertommen, D | 1 |
| Baardman, S; de Ligt, A; Dolstra, H; Hobo, W; Jansen, JH; Mousset, CM; Schaap, NPM; van der Waart, AB | 1 |
1 review(s) available for quinoxalines and akt-i-1,2 compound
| Article | Year |
|---|---|
Akt Pathway Inhibitors.
Topics: Antineoplastic Agents; Benzylamines; Cell Line, Tumor; Diamines; Drug Design; Heterocyclic Compounds, 3-Ring; Humans; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Phospholipids; Piperazines; Protein Conformation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Signal Transduction; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Thiophenes | 2020 |
32 other study(ies) available for quinoxalines and akt-i-1,2 compound
| Article | Year |
|---|---|
Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.
Topics: Animals; Antineoplastic Agents; Combinatorial Chemistry Techniques; Disease Models, Animal; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Naphthyridines; Proto-Oncogene Proteins c-akt; Structure-Activity Relationship | 2008 |
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Adenosine Triphosphate; Apoptosis Regulatory Proteins; Benzylamines; Binding, Competitive; Blood Proteins; Carcinoma; Caspases; Cell Line, Tumor; Cloning, Molecular; Enzyme Activation; Enzyme Inhibitors; Female; Heterocyclic Compounds, 2-Ring; Humans; Isoenzymes; Male; Membrane Glycoproteins; Molecular Structure; Peptides; Phosphoproteins; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Sequence Homology, Amino Acid; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Uterine Cervical Neoplasms | 2005 |
CARMA1 is required for Akt-mediated NF-kappaB activation in T cells.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; B-Cell CLL-Lymphoma 10 Protein; Benzylamines; CARD Signaling Adaptor Proteins; CD28 Antigens; Cells, Cultured; Enzyme Inhibitors; Guanylate Cyclase; Humans; I-kappa B Kinase; I-kappa B Proteins; Jurkat Cells; NF-kappa B; NFATC Transcription Factors; Oncogene Protein v-akt; Phosphorylation; PTEN Phosphohydrolase; Quinoxalines; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2006 |
Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells.
Topics: Animals; Benzylamines; Carcinoma, Hepatocellular; Cell Line, Tumor; Enzyme Inhibitors; Genes, Reporter; Gluconeogenesis; Insulin; Liver; Liver Neoplasms; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2007 |
Neuroprotective effect of humanin on cerebral ischemia/reperfusion injury is mediated by a PI3K/Akt pathway.
Topics: Androstadienes; Animals; Benzylamines; Blotting, Western; Brain; Brain Ischemia; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Infarction; Glucose; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Male; Mice; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Reperfusion Injury; Signal Transduction; Wortmannin | 2008 |
The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Chloroquine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Molecular Structure; Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Stereoisomerism; Structure-Activity Relationship | 2008 |
The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB.
Topics: Benzylamines; Humans; Phosphorylation; Platelet Activation; Platelet Aggregation; Protein Kinase C; Proto-Oncogene Proteins c-akt; Quinoxalines; Receptor, PAR-1 | 2008 |
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Benzylamines; Cell Cycle; Cell Line, Tumor; Chloroquine; Drug Interactions; Female; Furans; Humans; Lysosomes; Macrolides; Mice; Mice, Nude; Mitochondria; Mutation; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proton-Translocating ATPases; PTEN Phosphohydrolase; Pyridines; Pyrimidines; Quinoxalines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Ubiquitin-Activating Enzymes; Xenograft Model Antitumor Assays | 2008 |
Akt inhibitors induce apoptosis in chronic lymphocytic leukemia cells.
Topics: Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; B-Lymphocytes; Benzylamines; Blotting, Western; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Indazoles; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tumor Suppressor Protein p53 | 2009 |
Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Benzimidazoles; Carcinoma, Hepatocellular; Cell Line, Tumor; Chromones; Humans; Inhibitory Concentration 50; Liver Neoplasms; Morpholines; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; Wortmannin | 2011 |
Effects of nominally selective inhibitors of the kinases PI3K, SGK1 and PKB on the insulin-dependent control of epithelial Na+ absorption.
Topics: Absorption; Androstadienes; Animals; Benzoates; Benzylamines; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Epithelial Cells; Furans; Immediate-Early Proteins; Indazoles; Insulin; Ion Transport; Kidney Tubules, Collecting; Membrane Potentials; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Quinoxalines; Sodium; Sulfonamides; Wortmannin | 2010 |
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
Topics: Animals; Benzylamines; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Therapy, Combination; Feedback, Physiological; Female; Forkhead Transcription Factors; Gefitinib; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Lapatinib; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Models, Biological; Multiprotein Complexes; Neoplasms; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Quinoxalines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, IGF Type 1; Receptor, Insulin; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Up-Regulation; Xenograft Model Antitumor Assays | 2011 |
Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B.
Topics: Acylation; Adipocytes; Adrenergic beta-Agonists; Animals; Benzimidazoles; Blotting, Western; Cells, Cultured; Class Ib Phosphatidylinositol 3-Kinase; Colforsin; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Drug Interactions; Ghrelin; Glycerol; Intra-Abdominal Fat; Isoproterenol; Lipolysis; Male; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinolones; Quinoxalines; Rats; Rats, Wistar; Thiazolidinediones | 2011 |
Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Genetically Modified; Behavior, Animal; Benzylamines; Brain; Cell Count; CREB-Binding Protein; Dopamine; Dopamine Agents; Drug Interactions; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; gamma-Aminobutyric Acid; Gene Expression Regulation, Developmental; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Green Fluorescent Proteins; Homeodomain Proteins; Larva; Microscopy, Confocal; Movement; Neurons; Oncogene Protein v-akt; Phosphorylation; Quinoxalines; Receptors, Dopamine D2; Signal Transduction; Threonine; Transcription Factors; Tyrosine 3-Monooxygenase; Zebrafish | 2011 |
Effect of PI3K/Akt pathway inhibition-mediated G1 arrest on chemosensitization in ovarian cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzylamines; Cell Line, Tumor; Chromones; Cisplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Female; G1 Phase Cell Cycle Checkpoints; Gemcitabine; Humans; Morpholines; Ovarian Neoplasms; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; Topotecan | 2012 |
Modulation of sodium iodide symporter expression and function by LY294002, Akti-1/2 and Rapamycin in thyroid cells.
Topics: Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chromones; Enzyme Inhibitors; Flavonoids; HEK293 Cells; Humans; Iodine Radioisotopes; Mechanistic Target of Rapamycin Complex 1; Morpholines; Multiprotein Complexes; Phosphoinositide-3 Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; RNA, Messenger; Sirolimus; Symporters; Thyroid Gland; Thyrotropin; TOR Serine-Threonine Kinases | 2012 |
Salmonella transforms follicle-associated epithelial cells into M cells to promote intestinal invasion.
Topics: Aminophenols; Animals; Bacterial Proteins; Benzylamines; beta Catenin; Cell Differentiation; Cell Transdifferentiation; Cells, Cultured; Chromones; Enterocytes; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Intestinal Mucosa; Maleimides; Mice; Mice, Inbred C57BL; Morpholines; NF-kappa B; Peptides; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Salmonella Infections; Salmonella typhimurium; Snail Family Transcription Factors; Transcription Factor RelB; Transcription Factors; Vimentin; Wnt Proteins; Wnt Signaling Pathway | 2012 |
Cancer associated E17K mutation causes rapid conformational drift in AKT1 pleckstrin homology (PH) domain.
Topics: Benzimidazoles; Databases, Protein; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutation; Protein Stability; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quinoxalines; Thermodynamics | 2013 |
Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.
Topics: Allosteric Regulation; Antineoplastic Agents; Ascites; Autophagy; Benzylamines; Cell Line, Tumor; Cell Survival; Chloroquine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Humans; Inhibitory Concentration 50; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Quinoxalines; Spheroids, Cellular | 2014 |
Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy.
Topics: Animals; Benzimidazoles; CD8-Positive T-Lymphocytes; Cells, Cultured; Combined Modality Therapy; Cytotoxicity, Immunologic; Female; Humans; Immunotherapy, Adoptive; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Minor Histocompatibility Antigens; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Signal Transduction; Transplantation Conditioning; Xenograft Model Antitumor Assays | 2014 |
Effects of insulin on human pancreatic cancer progression modeled in vitro.
Topics: Benzylamines; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Disease Progression; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Insulin; MAP Kinase Signaling System; Models, Biological; Pancreatic Ducts; Pancreatic Neoplasms; Phenols; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinoxalines | 2014 |
Akt‑mediated phosphorylation of Oct4 is associated with the proliferation of stem‑like cancer cells.
Topics: Animals; Benzylamines; Brain Neoplasms; Carcinoma, Hepatocellular; Cell Division; Cell Line, Tumor; Cell Nucleus; Culture Media; Glioblastoma; Heterografts; Humans; Indoles; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Proteins; Neoplastic Stem Cells; Octamer Transcription Factor-3; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinoxalines; Receptors, Aryl Hydrocarbon; RNA Interference; RNA, Small Interfering; Signal Transduction; Spheroids, Cellular; Thiazoles | 2015 |
Radiosensitization of Primary Human Glioblastoma Stem-like Cells with Low-Dose AKT Inhibition.
Topics: Adult; Aged; Apoptosis; Benzimidazoles; Brain Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Female; Glioblastoma; Humans; Male; Middle Aged; Molecular Targeted Therapy; Neoplastic Stem Cells; Precision Medicine; Proto-Oncogene Proteins c-akt; Quinoxalines; Radiation-Sensitizing Agents; Tumor Cells, Cultured | 2015 |
Lactoferrin attenuates fatty acid-induced lipotoxicity via Akt signaling in hepatocarcinoma cells.
Topics: Animals; Anthracenes; Apoptosis; Benzimidazoles; Cattle; Fatty Acids, Nonesterified; Hep G2 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Lactoferrin; Lipid Metabolism; Lipotropic Agents; Liver; MAP Kinase Signaling System; Non-alcoholic Fatty Liver Disease; Peptide Fragments; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinoxalines | 2015 |
Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts.
Topics: Animals; Benzimidazoles; Biomarkers; Bone Marrow Cells; Cell Fusion; Cell Nucleus; Cells, Cultured; Crosses, Genetic; Cytokinesis; Luminescent Proteins; Male; Mice, Transgenic; Myeloid Progenitor Cells; Osteoclasts; Osteogenesis; Osteolysis; Phosphorylation; Polyploidy; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Quinoxalines; RANK Ligand; Recombinant Fusion Proteins | 2016 |
Autophagy prevention sensitizes AKTi-1/2-induced anti-hepatocellular carcinoma cell activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Autophagy; Benzylamines; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Synergism; Female; Hep G2 Cells; Humans; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Molecular Targeted Therapy; Quinoxalines; Treatment Outcome | 2016 |
SopB-Mediated Recruitment of SNX18 Facilitates
Topics: Animals; Bacterial Proteins; Benzylamines; cdc42 GTP-Binding Protein; Cell Membrane; Cell Surface Extensions; Cytosol; Dynamin II; Gene Knockdown Techniques; HEK293 Cells; Host-Pathogen Interactions; Humans; Mice; Mutation; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Pinocytosis; Quinoxalines; rac1 GTP-Binding Protein; RAW 264.7 Cells; Salmonella Infections; Salmonella typhimurium; Sorting Nexins; Type III Secretion Systems; Vacuoles; Virulence; Wiskott-Aldrich Syndrome Protein, Neuronal | 2017 |
Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Topics: Antineoplastic Agents; Apoptosis; Benzylamines; Caspase 3; Caspase 7; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Forkhead Box Protein O1; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Heterocyclic Compounds, 3-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Inhibitory Concentration 50; Mesothelioma; Oxadiazoles; Phosphorylation; Phosphorylcholine; Pleural Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinoxalines; Sulfonamides; Thiadiazoles; Thiophenes | 2017 |
RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines.
Topics: A549 Cells; Apoptosis; Benzimidazoles; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; HEK293 Cells; Humans; Lung Neoplasms; Mesothelioma; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinoxalines; Retinoblastoma-Like Protein p130; RNA, Messenger | 2018 |
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms.
Topics: Aminopyridines; Animals; Benzimidazoles; CHO Cells; Cricetinae; Cricetulus; Hep G2 Cells; Heterocyclic Compounds, 3-Ring; Humans; Imidazoles; Phosphorylcholine; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Pyrroles; Quinoxalines; Receptors, LDL; Ribonucleosides; RNA Stability; RNA, Messenger; Transcriptional Activation | 2019 |
Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.
Topics: Acetyl-CoA Carboxylase; Adipocytes; Adipose Tissue, White; Animals; Benzylamines; Heterocyclic Compounds, 3-Ring; Insulin; Lipogenesis; Male; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinoxalines; Rats; Rats, Wistar | 2020 |
Cell composition and expansion strategy can reduce the beneficial effect of AKT-inhibition on functionality of CD8
Topics: Benzimidazoles; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Humans; Quinoxalines | 2020 |