quinoxalines has been researched along with 6-(1h-imidazol-1-yl)-7-nitro-2,3(1h,4h)-quinoxalinedione in 35 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 28 (80.00) | 18.2507 |
| 2000's | 6 (17.14) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanada, T; Izumisawa, N; Kawakami, A; Ohata, T; Okeda, R | 1 |
| Furuya, T; Hidaka, K; Kawasaki, S; Kubota, H; Murase, K; Ohmori, J; Okada, M; Sakamoto, S; Shimizu-Sasamata, M; Togami, J | 1 |
| Anzilotti, KF; Jackson, PF; Rissolo, KC; Stauch Slusher, B | 1 |
| Hatanaka, K; Kawasaki-Yatsugi, S; Koshiya, K; Murase, K; Ohmori, J; Okada, M; Sakamoto, S; Shimizu-Sasamata, M; Togami, J; Usuda, S; Yatsugi, S | 1 |
| Kawasaki-Yatsugi, S; Koshiya, K; Sakamoto, S; Shimizu-Sasamata, M; Takahashi, M; Uematsu, D; Yatsugi, S | 1 |
| Mary, V; Stutzmann, JM; Wahl, F | 1 |
| Ohmori, J; Okada, M; Sakamoto, S; Shimizu-Sasamata, M | 1 |
| Kohara, A; Okada, M; Yamaguchi, T | 1 |
| Shiraishi, K | 2 |
| Cai, H; Fujishima, M; Ibayashi, S; Nakane, H; Uchimura, H; Yao, H | 1 |
| Umemura, K | 1 |
| Li, HB; Matsumoto, K; Watanabe, H; Yamamoto, M | 1 |
| Kawasaki-Yatsugi, S; Koshiya, K; Shimizu-Sasamata, M; Yatsugi, S | 1 |
| Homma, M; Ikeda, Y; Kondo, K; Nakashima, M; Teraya, Y; Uematsu, T; Umemura, K; Yoshida, H | 1 |
| Nakashima, M; Shimakura, A; Umemura, K | 1 |
| Ashby, CR; Katsumori, H; Minabe, Y; Osawa, M | 1 |
| Ohno, K; Okada, M; Sakamoto, S; Tsutsumi, R; Yamaguchi, T | 1 |
| Bleuel, Z; Clifford, MM; Ellis, GJ; Humbel, U; Klingelschmidt, A; Messer, J; Mutel, V; Richards, JG; Trube, G | 1 |
| Inami, H; Kohara, A; Ohno, K; Okada, M; Sakamoto, S; Shimizu-Sasamata, M; Shishikura, J; Takahashi, M; Tsutsumi, R; Yamaguchi, T | 1 |
| Kawasaki-Yatsugi, S; Shimizu-Sasamata, M; Yamaguchi, T; Yatsugi, S | 1 |
| Ichiki, C; Kawasaki-Yatsugi, S; Shimizu-Sasamata, M; Yamaguchi, T; Yatsugi, S | 1 |
| Li, H; Matsumoto, K; Watanabe, H | 1 |
| Ikeda, Y; Kondo, K; Takamatsu, H; Umemura, K | 1 |
| Arias, RL; Bowlby, MR; Tasse, JR | 1 |
| Funato, H; Kohsaka, S; Mochizuki, H; Shimojo, M; Takasugi, K; Yamamoto, I | 1 |
| Kitamura, Y; Kodama, M; Koyama, F; Kuroda, S; Morimoto, K; Sato, K; Sato, T; Yamada, N | 1 |
| Nakamura, K; Shirane, M | 1 |
| Bohme, GA; Boireau, A; Cheve, M; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| Li, JY; Matsumoto, M; Nakano, M; Ueda, H; Yanagihara, T | 1 |
| Chung, EH; Egashira, N; Egawa, T; Fujiwara, M; Hatip-Al-Khatib, I; Irie, K; Iwasaki, K; Mishima, K | 1 |
| Apostolides, PF; Brown, J; Dudman, JT; Kahuno, E; Kim, C; Lavis, LD; Lindo, S; Mensh, BD; Shields, BC; Tadross, MR | 1 |
1 review(s) available for quinoxalines and 6-(1h-imidazol-1-yl)-7-nitro-2,3(1h,4h)-quinoxalinedione
| Article | Year |
|---|---|
[A novel photochemical model of the middle cerebral artery for thrombosis research and evaluation of anti-thrombotic agents].
Topics: Animals; Disease Models, Animal; Drug Evaluation; Fibrinolytic Agents; Fluorescent Dyes; Glutamic Acid; Intracranial Embolism and Thrombosis; Light; Magnetic Resonance Imaging; Nicotinic Acids; Photochemistry; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rose Bengal | 1997 |
1 trial(s) available for quinoxalines and 6-(1h-imidazol-1-yl)-7-nitro-2,3(1h,4h)-quinoxalinedione
| Article | Year |
|---|---|
Pharmacokinetics and safety of the novel amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist YM90K in healthy men.
Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Half-Life; Humans; Infusions, Intravenous; Male; Neuroprotective Agents; Quinoxalines; Receptors, AMPA; Spectrophotometry, Ultraviolet | 1997 |
33 other study(ies) available for quinoxalines and 6-(1h-imidazol-1-yl)-7-nitro-2,3(1h,4h)-quinoxalinedione
| Article | Year |
|---|---|
YM90K, an AMPA antagonist, has no neurotoxic effects on cerebrocortical neurons in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Maleate; Female; Gyrus Cinguli; Immunohistochemistry; Microscopy, Electron; Quinoxalines; Rats; Rats, Inbred F344; Receptors, AMPA | 1995 |
6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Binding Sites; Brain; Imidazoles; Male; Mice; Mice, Inbred DBA; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship | 1994 |
Centrally-administered AMPA antagonists increase locomotion in parkinsonian rats.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Excitatory Amino Acid Antagonists; Male; Mesencephalon; Microinjections; Motor Activity; Oxidopamine; Parkinson Disease, Secondary; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Substantia Nigra | 1995 |
YM90K: pharmacological characterization as a selective and potent alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor antagonist.
Topics: Animals; Anticonvulsants; Brain Ischemia; Cerebral Infarction; Corpus Striatum; Gerbillinae; Ischemia; Male; Mice; Mice, Inbred DBA; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Seizures | 1996 |
Neuroprotective effect of YM90K, a novel AMPA/kainate receptor antagonist, in focal cerebral ischemia in cats.
Topics: Animals; Blood Pressure; Body Temperature; Brain; Cats; Electroencephalography; Hydrogen-Ion Concentration; Ischemic Attack, Transient; Male; Neurons; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid | 1996 |
Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Neurons; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Riluzole; Synaptic Transmission; Thiazoles; Triazines | 1995 |
Novel AMPA receptor antagonists: synthesis and structure-activity relationships of 1-hydroxy-7-(1H-imidazol-1-yl)-6-nitro-2,3(1H,4H)- quinoxalinedione and related compounds.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Excitatory Amino Acid Antagonists; Hydroxylation; Imidazoles; Molecular Structure; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Tritium | 1996 |
Characterization of YM90K, a selective and potent antagonist of AMPA receptors, in rat cortical mRNA-injected Xenopus oocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Cerebral Cortex; Dose-Response Relationship, Drug; Kainic Acid; Male; Oocytes; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 1996 |
A new non-NMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Anticonvulsants; Brain; Dizocilpine Maleate; Glucose; Hippocampus; Kainic Acid; Male; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
AMPA receptor antagonist, YM90K, reduces infarct volume in thrombotic distal middle cerebral artery occlusion in spontaneously hypertensive rats.
Topics: Animals; Arterial Occlusive Diseases; Cerebral Infarction; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Hypertension; Intracranial Embolism and Thrombosis; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, AMPA | 1997 |
NMDA but not AMPA receptor antagonists impair the delay-interposed radial maze performance of rats.
Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory, Short-Term; Pipecolic Acids; Psychomotor Performance; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Space Perception | 1997 |
Neuroprotective effect of YM90K, an AMPA-receptor antagonist, against delayed neuronal death induced by transient global cerebral ischemia in gerbils and rats.
Topics: Animals; Body Temperature; Brain Ischemia; Cell Death; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar | 1997 |
A new nonNMDA antagonist modifies the local cerebral glucose utilization in kainate-induced generalized seizure.
Topics: Animals; Autoradiography; Brain; Deoxyglucose; Excitatory Amino Acid Antagonists; Glucose; Hippocampus; Kainic Acid; Male; Nerve Net; Neuroprotective Agents; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Seizures | 1997 |
Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia.
Topics: Animals; Cerebral Arteries; Cerebral Cortex; Cerebral Infarction; Corpus Striatum; Endothelium, Vascular; Excitatory Amino Acid Antagonists; Ischemic Attack, Transient; Male; Neuroprotective Agents; Platelet Adhesiveness; Platelet Aggregation; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA | 1997 |
Acute effects of various GABA receptor agonists and glutamate antagonists on focal hippocampal seizures in freely moving rats elicited by low-frequency stimulation.
Topics: Animals; Anticonvulsants; Ataxia; Carbamazepine; Diazepam; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; GABA Agonists; Hippocampus; Kynurenic Acid; Male; Muscimol; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Seizures | 1998 |
The AMPA-receptor antagonist YM90K reduces AMPA receptor-mediated excitotoxicity in rat hippocampal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Cells, Cultured; Diuretics; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Kainic Acid; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Sodium Chloride Symporter Inhibitors | 1998 |
Binding characteristics of a potent AMPA receptor antagonist [3H]Ro 48-8587 in rat brain.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Chemistry; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Imidazoles; In Situ Hybridization; Kainic Acid; Kinetics; Male; N-Methylaspartate; Quinazolines; Quinoxalines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; RNA, Messenger; Tritium | 1998 |
In-vitro characterization of YM872, a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Binding, Competitive; Buffers; Cells, Cultured; Excitatory Amino Acid Antagonists; Hippocampus; Imidazoles; Kainic Acid; Male; Neuroprotective Agents; Oocytes; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Solubility; Xenopus laevis | 1998 |
Delayed treatment with YM90K, an AMPA receptor antagonist, protects against ischaemic damage after middle cerebral artery occlusion in rats.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Dose-Response Relationship, Drug; Guanidines; Injections, Intravenous; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Inbred F344; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors | 1998 |
YM90K, an AMPA receptor antagonist, protects against ischemic damage caused by permanent and transient middle cerebral artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1998 |
An alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist and an N-methyl-D-aspartate (NMDA) channel blocker synergistically impair spatial memory in rats.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; Excitatory Amino Acid Antagonists; Male; Maze Learning; Memory; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1998 |
Neuroprotective effects depend on the model of focal ischemia following middle cerebral artery occlusion.
Topics: Animals; Brain Edema; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Electrocoagulation; Immunosuppressive Agents; Injections, Intraperitoneal; Injections, Intravenous; Intracranial Embolism and Thrombosis; Male; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Tacrolimus | 1998 |
Neuroprotective interaction effects of NMDA and AMPA receptor antagonists in an in vitro model of cerebral ischemia.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hypoxia; Male; Neuroprotective Agents; Pipecolic Acids; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 1999 |
Neuroprotective action of a novel compound--M50463--in primary cultured neurons.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Batrachotoxins; Binding Sites; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cell Death; Cells, Cultured; Culture Media, Serum-Free; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Indoles; Neurons; Neuroprotective Agents; Neurotoxins; Nicardipine; Nitroprusside; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Thiazoles; Veratrine; Vitamin E | 1999 |
Effects of YM90K, a selective AMPA receptor antagonist, on amygdala-kindling and long-term hippocampal potentiation in the rat.
Topics: Amygdala; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Kindling, Neurologic; Long-Term Potentiation; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 1999 |
YM 900. YM 90K.
Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Drugs, Investigational; Excitatory Amino Acid Antagonists; Gerbillinae; Humans; Male; Mice; Neuroprotective Agents; Quinoxalines; Stroke | 1999 |
Group II metabotropic glutamate receptors are a common target of N-anisoyl-GABA and 1S,3R-ACPD in enhancing ACh release in the prefrontal cortex of freely moving SHRSP.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Anisoles; Benzoates; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Indans; Male; Microdialysis; Perfusion; Prefrontal Cortex; Quinoxalines; Rats; Rats, Inbred SHR; Receptors, AMPA; Receptors, Metabotropic Glutamate; Thalamic Nuclei; Wakefulness | 2000 |
8-Methylureido-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazines: highly potent in vivo AMPA antagonists.
Topics: Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Mice; Oocytes; Pyrazines; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Tetrazoles; Xenopus laevis | 2000 |
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea | 2000 |
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
Topics: Animals; Anticonvulsants; Carboxylic Acids; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Injections, Intravenous; Isoquinolines; Mice; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Xenopus | 2001 |
A potent AMPA/kainate receptor antagonist, YM90K, attenuates the loss of N-acetylaspartate in the hippocampal CA1 area after transient unilateral forebrain ischemia in gerbils.
Topics: Animals; Aspartic Acid; Brain Ischemia; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Prosencephalon; Quinoxalines; Receptors, AMPA; Receptors, Kainic Acid | 2001 |
Non-NMDA mechanism in the inhibition of cellular apoptosis and memory impairment induced by repeated ischemia in rats.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neurons; Neuroprotective Agents; Quinoxalines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Reperfusion Injury | 2004 |
Deconstructing behavioral neuropharmacology with cellular specificity.
Topics: Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Drug Design; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Mice; Muscarinic Antagonists; Neurons; Optogenetics; Parkinson Disease; Quinoxalines; Receptors, Glutamate | 2017 |