quinoxalines has been researched along with 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione in 65 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 26 (40.00) | 29.6817 |
2010's | 35 (53.85) | 24.3611 |
2020's | 4 (6.15) | 2.80 |
Authors | Studies |
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Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR | 1 |
Auberson, YP; Mallon, AP; Stone, TW | 1 |
Berberich, S; Hvalby, Ø; Jensen, V; Köhr, G; Pawlak, V; Punnakkal, P; Seeburg, PH | 1 |
Toyoda, H; Zhao, MG; Zhuo, M | 1 |
Jia, Y; Kaang, BK; Ko, SW; Lee, YS; Li, BM; Shum, F; Toyoda, H; Wu, LJ; Xu, H; Zhang, XH; Zhao, MG; Zhuo, M | 1 |
Jones, RS; Woodhall, GL; Yang, J | 1 |
Neyton, J; Paoletti, P | 1 |
Bonci, A; Borgland, SL; Fields, HL; Sarti, F; Taha, SA | 1 |
Baudry, M; Zhou, M | 1 |
Chen, PE; Frizelle, PA; Wyllie, DJ | 1 |
Auberson, YP; Izumi, Y; Zorumski, CF | 1 |
Bannister, NJ; Bartlett, TE; Bashir, ZI; Bortolotto, ZA; Collett, VJ; Collingridge, GL; Dargan, SL; Fitzjohn, SM; Lodge, D; Massey, PV | 1 |
Christie, BR; Fox, CJ; Russell, KI; Wang, YT | 1 |
Bi, GQ; Gerkin, RC; Lau, PM; Nauen, DW; Wang, YT | 1 |
Cao, X; Ren, M; Wu, LJ; Xu, H; Zhuo, M | 1 |
Coserea, I; Fuchs, EC; Köhr, G; Monyer, H; Pawlak, V; Seeburg, PH; von Engelhardt, J | 1 |
Caunt, C; Christie, BR; James, R; Kannangara, T; Samadi, S; Schibuk, E; Titterness, AK; Vasuta, C | 1 |
Chandler, LJ; Luong, NT; Mulholland, PJ; Woodward, JJ | 1 |
Davis, M; Walker, DL | 1 |
Auberson, YP; Fantin, M; Morari, M | 1 |
Chen, Q; Li, BM; Liu, F; Xiong, ZQ; Zhang, CL; Zhang, XH; Zhuo, M | 1 |
de Marchena, J; Middlebrooks, PG; Philpot, BD; Roberts, AC; Valakh, V; Wilfley, LR; Yashiro, K | 1 |
Chen, M; Chen, Q; Chen, XJ; Duan, WH; Feng, XY; Lu, TJ; Xiong, ZQ; Xu, L; Zhou, Y | 1 |
Anastasio, NC; Johnson, KM; O'Connor, ZR; Xia, Y | 1 |
Auberson, YP; Chen, L; Hu, M; Hu, Y; Li, LX; Luo, CX; Sun, YJ; Wu, JY; Zhou, QG; Zhu, DY | 1 |
Bose, R; Parkinson, FE; Zamzow, CR | 1 |
Chen, Y; Feng, C; Xiao, L | 1 |
Allyson, J; Auberson, Y; Cyr, M; Dontigny, E; Massicotte, G | 1 |
Bagot, RC; Dong, Z; Ge, Y; Howland, JG; Phillips, AG; Wang, YT; Wong, TP | 1 |
Chergui, K | 1 |
Dalton, GL; Floresco, SB; Phillips, AG; Wang, YT; Wu, DC | 1 |
Dehmel, M; Fischer, C; Henle, F; Leemhuis, J; Meyer, DK | 1 |
Auberson, YP; Bajouco, LM; Ferreira, IL; Mota, SI; Oliveira, CR; Rego, AC | 1 |
Bernardi, G; Berretta, N; Ledonne, A; Mango, D; Mercuri, NB | 1 |
Bortolato, M; Castelli, MP; Casu, A; Chen, K; Devoto, P; Flore, G; Frau, R; Godar, SC; Melis, M; Roncada, P; Shih, JC; Soggiu, A; Urbani, A | 1 |
Kocsis, B | 1 |
Brittain, JM; Brittain, MK; Brustovetsky, N; Brustovetsky, T; Cummins, TR; Khanna, R | 1 |
Bausch, SB; He, S; Shao, LR; Wang, Y | 1 |
Dumbreck, JK; Everitt, BJ; Gregory, BL; Merlo, E; Milton, AL; Ratano, P | 1 |
Auberson, YP; Budri, M; Calcagno, M; Dekundy, A; Mabrouk, OS; Mela, F; Morari, M; Parsons, CG; Viaro, R | 1 |
Morales, M; Spear, LP; Varlinskaya, EI | 1 |
Morales, M; Spear, LP | 1 |
Balsara, RD; Castellino, FJ; Donahue, DL; Ferreira, AN; Sheets, PL | 1 |
Adell, A; Auberson, YP; Campa, L; Jiménez-Sánchez, L | 1 |
Avchalumov, Y; Bode, C; Hamann, M; Kirschstein, T; Köhling, R; Porath, K; Richter, A; Richter, F; Sander, SE | 1 |
Brann, D; Liu, B; Tu, J; Wang, R; Yang, F; Zhang, Q; Zhang, X; Zhu, Y | 1 |
Kumar, G; Olley, J; Steckler, T; Talpos, J | 1 |
Arguello, AA; Blanton, M; Fuchs, RA; Healey, KL; Higginbotham, JA; Wells, AM; Xie, X | 1 |
Cao, J; Ding, ZY; Duan, TT; Jing, L; Mao, RR; Richter-Levin, G; Tan, JW; Tian, M; Xu, L; Yang, YX; Yuan, Q; Zhang, X; Zhou, QX; Zhu, YY | 1 |
Fan, H; Gao, D; Lai, Q; Li, X; Tang, X; Wang, W; Xu, T; Yin, X | 1 |
Burket, JA; Deutsch, SI; Green, TL | 1 |
Bortolotto, ZA; Burnell, ES; Collingridge, GL; Fernández-Fernández, D; France, G; Irvine, MW; Jane, DE; Monaghan, DT; Volianskis, A | 1 |
Chang, CH; Gean, PW; Huang, CH; Yu, YJ | 1 |
Furukawa, H; Romero-Hernandez, A | 1 |
Conti, P; De Micheli, C; Hansen, KB; Lind, GE; Mou, TC; Pinto, A; Pomper, MG; Tamborini, L | 1 |
Busquets-Garcia, A; Galera-López, L; Gomis-González, M; Maldonado, R; Martín-García, E; Ozaita, A; Puighermanal, E; Salgado-Mendialdúa, V | 1 |
Hata, T; Shinohara, K | 1 |
An, L; Li, X; Sun, W | 1 |
Adell, A; Auberson, YP; Gordillo-Salas, M; Pilar-Cuéllar, F | 1 |
Hu, K; Kocsis, B; Pittman-Polletta, B | 1 |
Kimura, H; Kondou, S; Mody, I; Nishi, T; Wei, X | 1 |
Bu, F; Nie, L; Quinn, JP; Wang, M | 1 |
Bing, YH; Chu, CP; Cui, BR; Cui, LN; Li, BX; Qiu, DL; Zhang, GJ; Zhang, XY | 1 |
Huang, Y; Li, D; Sun, N; Wang, C; Yu, Q; Zhang, YX; Zhou, WX | 1 |
Chen, P; Chen, Z; Liao, H; Liu, W; Pan, Y; Sheng, T; Xie, J; Yao, H; Zhang, Q; Zhou, H; Zou, Z | 1 |
65 other study(ies) available for quinoxalines and 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione
Article | Year |
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Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2004 |
Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Neural Inhibition; Organ Culture Techniques; Phenols; Piperidines; Protein Synthesis Inhibitors; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2005 |
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.
Topics: Animals; Cell Line; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Humans; Kidney; Long-Term Potentiation; Mice; Organ Culture Techniques; Piperidines; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection | 2005 |
Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chelating Agents; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gyrus Cinguli; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2005 |
Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory.
Topics: Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; Electroporation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fear; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Memory; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Phenols; Piperidines; Prefrontal Cortex; Protein Subunits; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering | 2005 |
Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.
Topics: Age Factors; Animals; Autoreceptors; Chronic Disease; Entorhinal Cortex; Epilepsy, Generalized; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenols; Pilocarpine; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus | 2006 |
Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Protein Subunits; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2006 |
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Benzoxazoles; Calcium Channel Blockers; Cocaine; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lysine; Male; Motor Activity; N-Methylaspartate; Naphthyridines; Neuronal Plasticity; Neurons; Neuropeptides; Orexins; Patch-Clamp Techniques; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Synapses; Thionucleotides; Time Factors; Tyrosine 3-Monooxygenase; Urea; Ventral Tegmental Area | 2006 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine | 2006 |
Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of sy
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Postsynaptic Potentials; Kinetics; Molecular Sequence Data; Oocytes; Point Mutation; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Synaptic Transmission; Xenopus laevis | 2006 |
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.
Topics: Animals; Chelating Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Organ Culture Techniques; Phenanthrolines; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Zinc | 2006 |
Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus.
Topics: Animals; Animals, Newborn; Cell Line, Transformed; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Transfection | 2007 |
Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Male; Neuronal Plasticity; Neurons; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2006 |
Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticity.
Topics: Algorithms; Animals; Binding, Competitive; Cells, Cultured; Excitatory Amino Acid Antagonists; Linear Models; Models, Neurological; Models, Statistical; Neuronal Plasticity; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substrate Specificity | 2007 |
Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2007 |
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors.
Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Mice; Mice, Knockout; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors | 2007 |
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus.
Topics: Animals; Aspartic Acid; Behavior, Animal; Dentate Gyrus; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Neurons; Physical Conditioning, Animal; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2007 |
Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway.
Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2008 |
Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test.
Topics: Amygdala; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; Male; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 2008 |
Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism.
Topics: Adrenergic Agents; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Globus Pallidus; Male; Microdialysis; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley | 2008 |
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory.
Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fear; Gene Expression Regulation; Genetic Engineering; Green Fluorescent Proteins; Male; Memory; Peptide Fragments; Psychophysics; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2008 |
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.
Topics: Aging; Animals; Blotting, Western; Electrophysiology; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Extracellular Space; Female; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Visual Cortex | 2008 |
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Death; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acid Antagonists; Humans; Ischemic Preconditioning; Membrane Proteins; Nerve Tissue Proteins; Neurons; Piperidines; Protein Isoforms; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2008 |
Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits.
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Locomotion; Male; Neurons; Phencyclidine; Piperidines; Quinoxalines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 2009 |
Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis.
Topics: Animals; Cell Proliferation; Cell Survival; Cerebral Ventricles; Dentate Gyrus; Learning; Male; Memory; Mice; Neurogenesis; Nitric Oxide Synthase Type I; Protein Subunits; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Spatial Behavior; Stem Cells; Substrate Specificity | 2009 |
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium.
Topics: Adenosine; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Inosine; N-Methylaspartate; Neurons; Piperidines; Purines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2009 |
Glucocorticoid rapidly enhances NMDA-evoked neurotoxicity by attenuating the NR2A-containing NMDA receptor-mediated ERK1/2 activation.
Topics: Animals; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Hippocampus; Imidazoles; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2010 |
Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices.
Topics: Amino Acid Sequence; Animals; Biotinylation; Blotting, Western; Calcium; Cyclin-Dependent Kinase 5; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; tau Proteins | 2010 |
Hippocampal long-term depression is required for the consolidation of spatial memory.
Topics: Animals; CA1 Region, Hippocampal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Maze Learning; Memory; Phenols; Piperazines; Piperidines; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spatial Behavior | 2010 |
Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens.
Topics: Animals; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2011 |
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear.
Topics: Amygdala; Animals; Association Learning; Conditioning, Classical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2012 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2012 |
Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Homeostasis; N-Methylaspartate; Neurons; Peptide Fragments; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2012 |
Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Dose-Response Relationship, Drug; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neural Pathways; Patch-Clamp Techniques; Phenols; Piperidines; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2012 |
NMDARs mediate the role of monoamine oxidase A in pathological aggression.
Topics: Aggression; Animals; Antisocial Personality Disorder; Autoradiography; Binding Sites; Blotting, Western; Corpus Striatum; Dizocilpine Maleate; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Mice; Mice, Knockout; Monoamine Oxidase; Motor Activity; Norepinephrine; Patch-Clamp Techniques; Phenols; Piperidines; Prosencephalon; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Serotonin | 2012 |
State-dependent increase of cortical gamma activity during REM sleep after selective blockade of NR2B subunit containing NMDA receptors.
Topics: Animals; Arousal; Brain Waves; Dizocilpine Maleate; Electroencephalography; Ketamine; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sleep, REM | 2012 |
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Topics: Animals; Blotting, Western; Calcium Signaling; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger | 2012 |
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Miniature Postsynaptic Potentials; Neuronal Plasticity; Neurons; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 1 | 2013 |
Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.
Topics: Amygdala; Animals; Anisomycin; Association Learning; Excitatory Amino Acid Antagonists; Fear; Male; Memory; Piperidines; Protein Synthesis Inhibitors; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2013 |
GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats.
Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra | 2013 |
Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Social Facilitation | 2013 |
The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
Topics: Aging; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibition, Psychological; Male; Motor Activity; Piperidines; Quinoxalines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Social Behavior | 2014 |
Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons.
Topics: Animals; Conotoxins; Dendrites; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Mice; Mice, Knockout; Optical Imaging; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate | 2014 |
The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phenols; Piperidines; Prefrontal Cortex; Quinoxalines; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin; Stereotyped Behavior | 2014 |
Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.
Topics: Animals; Animals, Newborn; Carrier Proteins; Corpus Striatum; Cricetinae; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Dystonin; Excitatory Amino Acid Antagonists; Female; Long-Term Potentiation; Magnesium; Male; Mutation; Nerve Tissue Proteins; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Time Factors; Valine | 2014 |
Prosurvival NMDA 2A receptor signaling mediates postconditioning neuroprotection in the hippocampus.
Topics: Analysis of Variance; Animals; Brain Ischemia; Calcium; CREB-Binding Protein; Dizocilpine Maleate; Hippocampus; Immunoprecipitation; Male; Maze Learning; Neuroprotective Agents; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Time Factors | 2015 |
Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation.
Topics: Animals; Association Learning; Cognition; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spatial Memory | 2015 |
Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats.
Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extinction, Psychological; Hippocampus; Male; Memory Consolidation; Pyrimidines; Quinoxalines; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Signal Transduction; src-Family Kinases | 2016 |
Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms.
Topics: Animals; CA1 Region, Hippocampal; Corticosterone; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Immunoblotting; Ketamine; Long-Term Potentiation; Male; Memory; Mineralocorticoid Receptor Antagonists; Phosphorylation; Quinoxalines; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Spironolactone; Stress, Psychological; Swimming | 2015 |
Effects of NMDA-Receptor Antagonist on the Expressions of Bcl-2 and Bax in the Subventricular Zone of Neonatal Rats with Hypoxia-Ischemia Brain Damage.
Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Dizocilpine Maleate; Hypoxia-Ischemia, Brain; Immunohistochemistry; Lateral Ventricles; Neuroprotective Agents; Phenols; Piperidines; Protein Subunits; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2015 |
Age-dependent effects on social interaction of NMDA GluN2A receptor subtype-selective antagonism.
Topics: Aging; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Interpersonal Relations; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred ICR; Motor Activity; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior | 2016 |
Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
Topics: Animals; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2017 |
Involvement of protein phosphatases in the destabilization of methamphetamine-associated contextual memory.
Topics: Amygdala; Animals; Anisomycin; Calcium Signaling; Conditioning, Classical; Dendritic Spines; Dizocilpine Maleate; Male; Memory Consolidation; Mental Recall; Methamphetamine; Mice, Inbred C57BL; Phosphoprotein Phosphatases; Protein Synthesis Inhibitors; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2016 |
Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Oocytes; Protein Binding; Protein Structure, Secondary; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 2017 |
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Topics: Animals; Binding, Competitive; Crystallography, X-Ray; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Domains; Protein Multimerization; Protein Subunits; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus | 2017 |
Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.
Topics: Animals; Anisomycin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hippocampus; Isoenzymes; Male; Memory, Short-Term; Mice; Microinjections; Neurogranin; Phenols; Phosphorylation; Piperidines; Protein Kinase C; Quinoxalines; Rimonabant; Signal Transduction; Sirolimus | 2018 |
Post-acquisition hippocampal blockade of the NMDA receptor subunit GluN2A but not GluN2B sustains spatial reference memory retention.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Maze Learning; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Spatial Memory | 2018 |
Distinct roles of prelimbic and infralimbic proBDNF in extinction of conditioned fear.
Topics: Analysis of Variance; Animals; Antibodies; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Male; Phenols; Piperidines; Prefrontal Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley | 2018 |
Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Male; Neuroglia; Neurons; Prefrontal Cortex; Quinoxalines; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; TOR Serine-Threonine Kinases | 2018 |
Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction.
Topics: Animals; Frontal Lobe; Hippocampus; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Theta Rhythm | 2018 |
Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons.
Topics: Animals; Cholesterol 24-Hydroxylase; Dentate Gyrus; Evoked Potentials; Excitatory Postsynaptic Potentials; Hydroxycholesterols; Interneurons; Male; Mice; Mice, Knockout; Neurons; Phenols; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials | 2019 |
Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors.
Topics: Animals; Cerebral Cortex; Connexins; Cortical Spreading Depression; Humans; Male; Mice; Migraine Disorders; Nerve Tissue Proteins; Phosphotransferases; Pyrimidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2020 |
NMDARs contribute to the facial stimuli-evoked mossy fiber-granule cell synaptic transmission in vivo in mice.
Topics: Animals; Cerebellar Cortex; Excitatory Amino Acid Antagonists; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Physical Stimulation; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine; Vibrissae | 2020 |
Reduced D-Serine Release May Contribute to Impairment of Long-Term Potentiation by Corticosterone in the Perforant Path-Dentate Gyrus.
Topics: Animals; Corticosterone; Dentate Gyrus; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Open Field Test; Perforant Pathway; Phenols; Piperidines; Quinolones; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Serine | 2021 |
Geniposide attenuates postischemic long-term potentiation via GluN2A.
Topics: Animals; Apoptosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; In Vitro Techniques; Infarction, Middle Cerebral Artery; Iridoids; Long-Term Potentiation; Neurons; Oxidants; PC12 Cells; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate | 2021 |