Page last updated: 2024-08-17

quinoxalines and 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione

quinoxalines has been researched along with 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione in 65 studies

Research

Studies (65)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's26 (40.00)29.6817
2010's35 (53.85)24.3611
2020's4 (6.15)2.80

Authors

AuthorsStudies
Auberson, YP; Bashir, ZI; Brown, MW; Collingridge, GL; Johnson, BE; Massey, PV; Molnar, E; Moult, PR1
Auberson, YP; Mallon, AP; Stone, TW1
Berberich, S; Hvalby, Ø; Jensen, V; Köhr, G; Pawlak, V; Punnakkal, P; Seeburg, PH1
Toyoda, H; Zhao, MG; Zhuo, M1
Jia, Y; Kaang, BK; Ko, SW; Lee, YS; Li, BM; Shum, F; Toyoda, H; Wu, LJ; Xu, H; Zhang, XH; Zhao, MG; Zhuo, M1
Jones, RS; Woodhall, GL; Yang, J1
Neyton, J; Paoletti, P1
Bonci, A; Borgland, SL; Fields, HL; Sarti, F; Taha, SA1
Baudry, M; Zhou, M1
Chen, PE; Frizelle, PA; Wyllie, DJ1
Auberson, YP; Izumi, Y; Zorumski, CF1
Bannister, NJ; Bartlett, TE; Bashir, ZI; Bortolotto, ZA; Collett, VJ; Collingridge, GL; Dargan, SL; Fitzjohn, SM; Lodge, D; Massey, PV1
Christie, BR; Fox, CJ; Russell, KI; Wang, YT1
Bi, GQ; Gerkin, RC; Lau, PM; Nauen, DW; Wang, YT1
Cao, X; Ren, M; Wu, LJ; Xu, H; Zhuo, M1
Coserea, I; Fuchs, EC; Köhr, G; Monyer, H; Pawlak, V; Seeburg, PH; von Engelhardt, J1
Caunt, C; Christie, BR; James, R; Kannangara, T; Samadi, S; Schibuk, E; Titterness, AK; Vasuta, C1
Chandler, LJ; Luong, NT; Mulholland, PJ; Woodward, JJ1
Davis, M; Walker, DL1
Auberson, YP; Fantin, M; Morari, M1
Chen, Q; Li, BM; Liu, F; Xiong, ZQ; Zhang, CL; Zhang, XH; Zhuo, M1
de Marchena, J; Middlebrooks, PG; Philpot, BD; Roberts, AC; Valakh, V; Wilfley, LR; Yashiro, K1
Chen, M; Chen, Q; Chen, XJ; Duan, WH; Feng, XY; Lu, TJ; Xiong, ZQ; Xu, L; Zhou, Y1
Anastasio, NC; Johnson, KM; O'Connor, ZR; Xia, Y1
Auberson, YP; Chen, L; Hu, M; Hu, Y; Li, LX; Luo, CX; Sun, YJ; Wu, JY; Zhou, QG; Zhu, DY1
Bose, R; Parkinson, FE; Zamzow, CR1
Chen, Y; Feng, C; Xiao, L1
Allyson, J; Auberson, Y; Cyr, M; Dontigny, E; Massicotte, G1
Bagot, RC; Dong, Z; Ge, Y; Howland, JG; Phillips, AG; Wang, YT; Wong, TP1
Chergui, K1
Dalton, GL; Floresco, SB; Phillips, AG; Wang, YT; Wu, DC1
Dehmel, M; Fischer, C; Henle, F; Leemhuis, J; Meyer, DK1
Auberson, YP; Bajouco, LM; Ferreira, IL; Mota, SI; Oliveira, CR; Rego, AC1
Bernardi, G; Berretta, N; Ledonne, A; Mango, D; Mercuri, NB1
Bortolato, M; Castelli, MP; Casu, A; Chen, K; Devoto, P; Flore, G; Frau, R; Godar, SC; Melis, M; Roncada, P; Shih, JC; Soggiu, A; Urbani, A1
Kocsis, B1
Brittain, JM; Brittain, MK; Brustovetsky, N; Brustovetsky, T; Cummins, TR; Khanna, R1
Bausch, SB; He, S; Shao, LR; Wang, Y1
Dumbreck, JK; Everitt, BJ; Gregory, BL; Merlo, E; Milton, AL; Ratano, P1
Auberson, YP; Budri, M; Calcagno, M; Dekundy, A; Mabrouk, OS; Mela, F; Morari, M; Parsons, CG; Viaro, R1
Morales, M; Spear, LP; Varlinskaya, EI1
Morales, M; Spear, LP1
Balsara, RD; Castellino, FJ; Donahue, DL; Ferreira, AN; Sheets, PL1
Adell, A; Auberson, YP; Campa, L; Jiménez-Sánchez, L1
Avchalumov, Y; Bode, C; Hamann, M; Kirschstein, T; Köhling, R; Porath, K; Richter, A; Richter, F; Sander, SE1
Brann, D; Liu, B; Tu, J; Wang, R; Yang, F; Zhang, Q; Zhang, X; Zhu, Y1
Kumar, G; Olley, J; Steckler, T; Talpos, J1
Arguello, AA; Blanton, M; Fuchs, RA; Healey, KL; Higginbotham, JA; Wells, AM; Xie, X1
Cao, J; Ding, ZY; Duan, TT; Jing, L; Mao, RR; Richter-Levin, G; Tan, JW; Tian, M; Xu, L; Yang, YX; Yuan, Q; Zhang, X; Zhou, QX; Zhu, YY1
Fan, H; Gao, D; Lai, Q; Li, X; Tang, X; Wang, W; Xu, T; Yin, X1
Burket, JA; Deutsch, SI; Green, TL1
Bortolotto, ZA; Burnell, ES; Collingridge, GL; Fernández-Fernández, D; France, G; Irvine, MW; Jane, DE; Monaghan, DT; Volianskis, A1
Chang, CH; Gean, PW; Huang, CH; Yu, YJ1
Furukawa, H; Romero-Hernandez, A1
Conti, P; De Micheli, C; Hansen, KB; Lind, GE; Mou, TC; Pinto, A; Pomper, MG; Tamborini, L1
Busquets-Garcia, A; Galera-López, L; Gomis-González, M; Maldonado, R; Martín-García, E; Ozaita, A; Puighermanal, E; Salgado-Mendialdúa, V1
Hata, T; Shinohara, K1
An, L; Li, X; Sun, W1
Adell, A; Auberson, YP; Gordillo-Salas, M; Pilar-Cuéllar, F1
Hu, K; Kocsis, B; Pittman-Polletta, B1
Kimura, H; Kondou, S; Mody, I; Nishi, T; Wei, X1
Bu, F; Nie, L; Quinn, JP; Wang, M1
Bing, YH; Chu, CP; Cui, BR; Cui, LN; Li, BX; Qiu, DL; Zhang, GJ; Zhang, XY1
Huang, Y; Li, D; Sun, N; Wang, C; Yu, Q; Zhang, YX; Zhou, WX1
Chen, P; Chen, Z; Liao, H; Liu, W; Pan, Y; Sheng, T; Xie, J; Yao, H; Zhang, Q; Zhou, H; Zou, Z1

Other Studies

65 other study(ies) available for quinoxalines and 5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione

ArticleYear
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-08, Volume: 24, Issue:36

    Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Dicarboxylic Acids; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Neurons; Neurotransmitter Uptake Inhibitors; Phenols; Picrotoxin; Piperidines; Protein Subunits; Pyrrolidines; Quinoxalines; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate

2004
Selective subunit antagonists suggest an inhibitory relationship between NR2B and NR2A-subunit containing N-methyl-D: -aspartate receptors in hippocampal slices.
    Experimental brain research, 2005, Volume: 162, Issue:3

    Topics: Animals; Calcineurin; Calcineurin Inhibitors; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Male; Neural Inhibition; Organ Culture Techniques; Phenols; Piperidines; Protein Synthesis Inhibitors; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission

2005
Lack of NMDA receptor subtype selectivity for hippocampal long-term potentiation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jul-20, Volume: 25, Issue:29

    Topics: Animals; Cell Line; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Humans; Kidney; Long-Term Potentiation; Mice; Organ Culture Techniques; Piperidines; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transfection

2005
Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex.
    The European journal of neuroscience, 2005, Volume: 22, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Chelating Agents; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gyrus Cinguli; In Vitro Techniques; Long-Term Synaptic Depression; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors

2005
Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory.
    Neuron, 2005, Sep-15, Volume: 47, Issue:6

    Topics: Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Electric Stimulation; Electroporation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fear; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Memory; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Phenols; Piperidines; Prefrontal Cortex; Protein Subunits; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering

2005
Tonic facilitation of glutamate release by presynaptic NR2B-containing NMDA receptors is increased in the entorhinal cortex of chronically epileptic rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jan-11, Volume: 26, Issue:2

    Topics: Age Factors; Animals; Autoreceptors; Chronic Disease; Entorhinal Cortex; Epilepsy, Generalized; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenols; Pilocarpine; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Status Epilepticus

2006
Relating NMDA receptor function to receptor subunit composition: limitations of the pharmacological approach.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Feb-01, Volume: 26, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Protein Subunits; Quinoxalines; Receptors, N-Methyl-D-Aspartate

2006
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine.
    Neuron, 2006, Feb-16, Volume: 49, Issue:4

    Topics: Analysis of Variance; Anesthetics, Local; Animals; Animals, Newborn; Behavior, Animal; Benzoxazoles; Calcium Channel Blockers; Cocaine; Cyclic AMP; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Immunohistochemistry; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lysine; Male; Motor Activity; N-Methylaspartate; Naphthyridines; Neuronal Plasticity; Neurons; Neuropeptides; Orexins; Patch-Clamp Techniques; Protein Kinase C; Quinoxalines; Rats; Rats, Sprague-Dawley; Synapses; Thionucleotides; Time Factors; Tyrosine 3-Monooxygenase; Urea; Ventral Tegmental Area

2006
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Mar-15, Volume: 26, Issue:11

    Topics: Age Factors; Animals; Biomarkers; Calpain; Dipeptides; Disks Large Homolog 4 Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Gene Expression Regulation, Developmental; Glucose; Hippocampus; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; L-Lactate Dehydrogenase; Membrane Proteins; N-Methylaspartate; Neurons; Oxygen; Phenols; Piperidines; Propidium; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spectrin; Valine

2006
Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of sy
    Molecular pharmacology, 2006, Volume: 70, Issue:3

    Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Postsynaptic Potentials; Kinetics; Molecular Sequence Data; Oocytes; Point Mutation; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Synaptic Transmission; Xenopus laevis

2006
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Jul-05, Volume: 26, Issue:27

    Topics: Animals; Chelating Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Organ Culture Techniques; Phenanthrolines; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine; Zinc

2006
Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus.
    Neuropharmacology, 2007, Volume: 52, Issue:1

    Topics: Animals; Animals, Newborn; Cell Line, Transformed; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; N-Methylaspartate; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Transfection

2007
Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo.
    Hippocampus, 2006, Volume: 16, Issue:11

    Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Male; Neuronal Plasticity; Neurons; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses

2006
Modular competition driven by NMDA receptor subtypes in spike-timing-dependent plasticity.
    Journal of neurophysiology, 2007, Volume: 97, Issue:4

    Topics: Algorithms; Animals; Binding, Competitive; Cells, Cultured; Excitatory Amino Acid Antagonists; Linear Models; Models, Neurological; Models, Statistical; Neuronal Plasticity; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Substrate Specificity

2007
Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex.
    Molecular pain, 2007, Apr-30, Volume: 3

    Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Gyrus Cinguli; Male; Mice; Mice, Inbred C57BL; Neural Inhibition; Organ Culture Techniques; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate

2007
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Calcium Channel Blockers; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Mice; Mice, Knockout; Mutation; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Time Factors

2007
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus.
    Hippocampus, 2007, Volume: 17, Issue:12

    Topics: Animals; Aspartic Acid; Behavior, Animal; Dentate Gyrus; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Neurons; Physical Conditioning, Animal; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate

2007
Brain-derived neurotrophic factor activation of extracellular signal-regulated kinase is autonomous from the dominant extrasynaptic NMDA receptor extracellular signal-regulated kinase shutoff pathway.
    Neuroscience, 2008, Jan-24, Volume: 151, Issue:2

    Topics: Animals; Blotting, Western; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Dizocilpine Maleate; Enzyme Activation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2008
Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test.
    Learning & memory (Cold Spring Harbor, N.Y.), 2008, Volume: 15, Issue:2

    Topics: Amygdala; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Fear; Male; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle

2008
Differential effect of NR2A and NR2B subunit selective NMDA receptor antagonists on striato-pallidal neurons: relationship to motor response in the 6-hydroxydopamine model of parkinsonism.
    Journal of neurochemistry, 2008, Volume: 106, Issue:2

    Topics: Adrenergic Agents; Animals; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Antagonists; Globus Pallidus; Male; Microdialysis; Motor Activity; Neurons; Oxidopamine; Parkinson Disease; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley

2008
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory.
    Neuropharmacology, 2008, Volume: 55, Issue:2

    Topics: Acoustic Stimulation; Amygdala; Animals; Behavior, Animal; Conditioning, Classical; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fear; Gene Expression Regulation; Genetic Engineering; Green Fluorescent Proteins; Male; Memory; Peptide Fragments; Psychophysics; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors

2008
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity.
    Journal of neurophysiology, 2008, Volume: 100, Issue:4

    Topics: Aging; Animals; Blotting, Western; Electrophysiology; Evoked Potentials, Visual; Excitatory Amino Acid Antagonists; Extracellular Space; Female; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuronal Plasticity; Patch-Clamp Techniques; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Subcellular Fractions; Visual Cortex

2008
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance.
    Stroke, 2008, Volume: 39, Issue:11

    Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Death; Cyclic AMP Response Element-Binding Protein; Excitatory Amino Acid Antagonists; Humans; Ischemic Preconditioning; Membrane Proteins; Nerve Tissue Proteins; Neurons; Piperidines; Protein Isoforms; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2008
Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits.
    Neuroscience, 2009, Nov-10, Volume: 163, Issue:4

    Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Locomotion; Male; Neurons; Phencyclidine; Piperidines; Quinoxalines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors

2009
Reduced spatial learning in mice treated with NVP-AAM077 through down-regulating neurogenesis.
    European journal of pharmacology, 2009, Nov-10, Volume: 622, Issue:1-3

    Topics: Animals; Cell Proliferation; Cell Survival; Cerebral Ventricles; Dentate Gyrus; Learning; Male; Memory; Mice; Neurogenesis; Nitric Oxide Synthase Type I; Protein Subunits; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Spatial Behavior; Stem Cells; Substrate Specificity

2009
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:10

    Topics: Adenosine; Animals; Calcium; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Egtazic Acid; Excitatory Amino Acid Antagonists; Inosine; N-Methylaspartate; Neurons; Piperidines; Purines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate

2009
Glucocorticoid rapidly enhances NMDA-evoked neurotoxicity by attenuating the NR2A-containing NMDA receptor-mediated ERK1/2 activation.
    Molecular endocrinology (Baltimore, Md.), 2010, Volume: 24, Issue:3

    Topics: Animals; Blotting, Western; Calcium; Cells, Cultured; Enzyme Inhibitors; Flavonoids; Glucocorticoids; Hippocampus; Imidazoles; Mifepristone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Neurons; p38 Mitogen-Activated Protein Kinases; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2010
Blockade of NR2A-containing NMDA receptors induces Tau phosphorylation in rat hippocampal slices.
    Neural plasticity, 2010, Volume: 2010

    Topics: Amino Acid Sequence; Animals; Biotinylation; Blotting, Western; Calcium; Cyclin-Dependent Kinase 5; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Male; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; tau Proteins

2010
Hippocampal long-term depression is required for the consolidation of spatial memory.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Sep-21, Volume: 107, Issue:38

    Topics: Animals; CA1 Region, Hippocampal; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Maze Learning; Memory; Phenols; Piperazines; Piperidines; Protein Subunits; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spatial Behavior

2010
Dopamine induces a GluN2A-dependent form of long-term depression of NMDA synaptic responses in the nucleus accumbens.
    Neuropharmacology, 2011, Volume: 60, Issue:6

    Topics: Animals; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Nucleus Accumbens; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

2011
NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear.
    Neuropharmacology, 2012, Volume: 62, Issue:2

    Topics: Amygdala; Animals; Association Learning; Conditioning, Classical; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2012
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons.
    Naunyn-Schmiedeberg's archives of pharmacology, 2012, Volume: 385, Issue:2

    Topics: Animals; Azabicyclo Compounds; Cells, Cultured; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; HeLa Cells; Hippocampus; Humans; N-Methylaspartate; Neurons; Organophosphonates; Phenols; Piperidines; Protein Subunits; Pseudopodia; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate

2012
Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures.
    Cell calcium, 2012, Volume: 51, Issue:2

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Homeostasis; N-Methylaspartate; Neurons; Peptide Fragments; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

2012
Hippocampus versus entorhinal cortex decoupling by an NR2 subunit-specific block of NMDA receptors in a rat in vitro model of temporal lobe epilepsy.
    Epilepsia, 2012, Volume: 53, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Animals; Dose-Response Relationship, Drug; Drug Interactions; Entorhinal Cortex; Excitatory Amino Acid Antagonists; Hippocampus; In Vitro Techniques; Neural Pathways; Patch-Clamp Techniques; Phenols; Piperidines; Potassium Channel Blockers; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2012
NMDARs mediate the role of monoamine oxidase A in pathological aggression.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Jun-20, Volume: 32, Issue:25

    Topics: Aggression; Animals; Antisocial Personality Disorder; Autoradiography; Binding Sites; Blotting, Western; Corpus Striatum; Dizocilpine Maleate; Electrophysiological Phenomena; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Mice; Mice, Knockout; Monoamine Oxidase; Motor Activity; Norepinephrine; Patch-Clamp Techniques; Phenols; Piperidines; Prosencephalon; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Serotonin

2012
State-dependent increase of cortical gamma activity during REM sleep after selective blockade of NR2B subunit containing NMDA receptors.
    Sleep, 2012, Jul-01, Volume: 35, Issue:7

    Topics: Animals; Arousal; Brain Waves; Dizocilpine Maleate; Electroencephalography; Ketamine; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sleep, REM

2012
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
    Neuropharmacology, 2012, Volume: 63, Issue:6

    Topics: Animals; Blotting, Western; Calcium Signaling; Cell Survival; Cells, Cultured; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hippocampus; Microscopy, Fluorescence; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger

2012
Synaptic and extrasynaptic plasticity in glutamatergic circuits involving dentate granule cells following chronic N-methyl-D-aspartate receptor inhibition.
    Journal of neurophysiology, 2013, Volume: 109, Issue:6

    Topics: 2-Amino-5-phosphonovalerate; Animals; Dentate Gyrus; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Miniature Postsynaptic Potentials; Neuronal Plasticity; Neurons; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Vesicular Glutamate Transport Protein 1

2013
Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Jan-16, Volume: 33, Issue:3

    Topics: Amygdala; Animals; Anisomycin; Association Learning; Excitatory Amino Acid Antagonists; Fear; Male; Memory; Piperidines; Protein Synthesis Inhibitors; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate

2013
GluN2A and GluN2B NMDA receptor subunits differentially modulate striatal output pathways and contribute to levodopa-induced abnormal involuntary movements in dyskinetic rats.
    ACS chemical neuroscience, 2013, May-15, Volume: 4, Issue:5

    Topics: Animals; Corpus Striatum; Dopamine; Dopamine Agents; Dyskinesia, Drug-Induced; gamma-Aminobutyric Acid; Globus Pallidus; Glutamic Acid; Levodopa; Male; Microdialysis; Neostriatum; Oxidopamine; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substantia Nigra

2013
Low doses of the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, induces social facilitation in adolescent male rats.
    Behavioural brain research, 2013, Aug-01, Volume: 250

    Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; N-Methylaspartate; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Social Facilitation

2013
The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
    Psychopharmacology, 2014, Volume: 231, Issue:8

    Topics: Aging; Animals; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Inhibition, Psychological; Male; Motor Activity; Piperidines; Quinoxalines; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Social Behavior

2014
Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons.
    Neuropharmacology, 2014, Volume: 79

    Topics: Animals; Conotoxins; Dendrites; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Mice; Mice, Knockout; Optical Imaging; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Quinoxalines; Receptors, N-Methyl-D-Aspartate

2014
The role of GluN2A and GluN2B subunits on the effects of NMDA receptor antagonists in modeling schizophrenia and treating refractory depression.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:11

    Topics: Animals; Antidepressive Agents; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phenols; Piperidines; Prefrontal Cortex; Quinoxalines; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin; Stereotyped Behavior

2014
Role of striatal NMDA receptor subunits in a model of paroxysmal dystonia.
    Experimental neurology, 2014, Volume: 261

    Topics: Animals; Animals, Newborn; Carrier Proteins; Corpus Striatum; Cricetinae; Cytoskeletal Proteins; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Dystonin; Excitatory Amino Acid Antagonists; Female; Long-Term Potentiation; Magnesium; Male; Mutation; Nerve Tissue Proteins; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index; Time Factors; Valine

2014
Prosurvival NMDA 2A receptor signaling mediates postconditioning neuroprotection in the hippocampus.
    Hippocampus, 2015, Volume: 25, Issue:3

    Topics: Analysis of Variance; Animals; Brain Ischemia; Calcium; CREB-Binding Protein; Dizocilpine Maleate; Hippocampus; Immunoprecipitation; Male; Maze Learning; Neuroprotective Agents; Phenols; Piperidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Time Factors

2015
Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation.
    Psychopharmacology, 2015, Volume: 232, Issue:21-22

    Topics: Animals; Association Learning; Cognition; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Male; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Spatial Memory

2015
Contribution of an SFK-Mediated Signaling Pathway in the Dorsal Hippocampus to Cocaine-Memory Reconsolidation in Rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016, Volume: 41, Issue:3

    Topics: Animals; Cocaine; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extinction, Psychological; Hippocampus; Male; Memory Consolidation; Pyrimidines; Quinoxalines; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Self Administration; Signal Transduction; src-Family Kinases

2016
Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms.
    Scientific reports, 2015, Oct-09, Volume: 5

    Topics: Animals; CA1 Region, Hippocampal; Corticosterone; Depression; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Immunoblotting; Ketamine; Long-Term Potentiation; Male; Memory; Mineralocorticoid Receptor Antagonists; Phosphorylation; Quinoxalines; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glucocorticoid; Receptors, N-Methyl-D-Aspartate; Spironolactone; Stress, Psychological; Swimming

2015
Effects of NMDA-Receptor Antagonist on the Expressions of Bcl-2 and Bax in the Subventricular Zone of Neonatal Rats with Hypoxia-Ischemia Brain Damage.
    Cell biochemistry and biophysics, 2015, Volume: 73, Issue:2

    Topics: Animals; bcl-2-Associated X Protein; Disease Models, Animal; Dizocilpine Maleate; Hypoxia-Ischemia, Brain; Immunohistochemistry; Lateral Ventricles; Neuroprotective Agents; Phenols; Piperidines; Protein Subunits; Proto-Oncogene Proteins c-bcl-2; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2015
Age-dependent effects on social interaction of NMDA GluN2A receptor subtype-selective antagonism.
    Brain research bulletin, 2016, Volume: 125

    Topics: Aging; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Exploratory Behavior; Interpersonal Relations; Male; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred ICR; Motor Activity; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Stereotyped Behavior

2016
Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.
    Neuropharmacology, 2017, Volume: 112, Issue:Pt A

    Topics: Animals; Hippocampus; Long-Term Potentiation; Long-Term Synaptic Depression; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2017
Involvement of protein phosphatases in the destabilization of methamphetamine-associated contextual memory.
    Learning & memory (Cold Spring Harbor, N.Y.), 2016, Volume: 23, Issue:9

    Topics: Amygdala; Animals; Anisomycin; Calcium Signaling; Conditioning, Classical; Dendritic Spines; Dizocilpine Maleate; Male; Memory Consolidation; Mental Recall; Methamphetamine; Mice, Inbred C57BL; Phosphoprotein Phosphatases; Protein Synthesis Inhibitors; Quinoxalines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2016
Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077.
    Molecular pharmacology, 2017, Volume: 92, Issue:1

    Topics: Animals; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Oocytes; Protein Binding; Protein Structure, Secondary; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus laevis

2017
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 08-15, Volume: 114, Issue:33

    Topics: Animals; Binding, Competitive; Crystallography, X-Ray; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Models, Molecular; Oocytes; Patch-Clamp Techniques; Protein Domains; Protein Multimerization; Protein Subunits; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus

2017
Hippocampal Protein Kinase C Signaling Mediates the Short-Term Memory Impairment Induced by Delta9-Tetrahydrocannabinol.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018, Volume: 43, Issue:5

    Topics: Animals; Anisomycin; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hippocampus; Isoenzymes; Male; Memory, Short-Term; Mice; Microinjections; Neurogranin; Phenols; Phosphorylation; Piperidines; Protein Kinase C; Quinoxalines; Rimonabant; Signal Transduction; Sirolimus

2018
Post-acquisition hippocampal blockade of the NMDA receptor subunit GluN2A but not GluN2B sustains spatial reference memory retention.
    Neurobiology of learning and memory, 2018, Volume: 147

    Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Hippocampus; Maze Learning; Phenols; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Spatial Memory

2018
Distinct roles of prelimbic and infralimbic proBDNF in extinction of conditioned fear.
    Neuropharmacology, 2018, 03-15, Volume: 131

    Topics: Analysis of Variance; Animals; Antibodies; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Excitatory Amino Acid Antagonists; Extinction, Psychological; Fear; Male; Phenols; Piperidines; Prefrontal Cortex; Quinoxalines; Rats; Rats, Sprague-Dawley

2018
Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist.
    Translational psychiatry, 2018, 04-18, Volume: 8, Issue:1

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Male; Neuroglia; Neurons; Prefrontal Cortex; Quinoxalines; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; TOR Serine-Threonine Kinases

2018
Subunit-specific NMDAR antagonism dissociates schizophrenia subtype-relevant oscillopathies associated with frontal hypofunction and hippocampal hyperfunction.
    Scientific reports, 2018, 08-02, Volume: 8, Issue:1

    Topics: Animals; Frontal Lobe; Hippocampus; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Theta Rhythm

2018
Preferential enhancement of GluN2B-containing native NMDA receptors by the endogenous modulator 24S-hydroxycholesterol in hippocampal neurons.
    Neuropharmacology, 2019, Volume: 148

    Topics: Animals; Cholesterol 24-Hydroxylase; Dentate Gyrus; Evoked Potentials; Excitatory Postsynaptic Potentials; Hydroxycholesterols; Interneurons; Male; Mice; Mice, Knockout; Neurons; Phenols; Piperidines; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synaptic Potentials

2019
Sarcoma Family Kinase-Dependent Pannexin-1 Activation after Cortical Spreading Depression is Mediated by NR2A-Containing Receptors.
    International journal of molecular sciences, 2020, Feb-13, Volume: 21, Issue:4

    Topics: Animals; Cerebral Cortex; Connexins; Cortical Spreading Depression; Humans; Male; Mice; Migraine Disorders; Nerve Tissue Proteins; Phosphotransferases; Pyrimidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate

2020
NMDARs contribute to the facial stimuli-evoked mossy fiber-granule cell synaptic transmission in vivo in mice.
    Neuroscience letters, 2020, 09-25, Volume: 736

    Topics: Animals; Cerebellar Cortex; Excitatory Amino Acid Antagonists; Mice; Mice, Inbred ICR; N-Methylaspartate; Neurons; Physical Stimulation; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Valine; Vibrissae

2020
Reduced D-Serine Release May Contribute to Impairment of Long-Term Potentiation by Corticosterone in the Perforant Path-Dentate Gyrus.
    Neurochemical research, 2021, Volume: 46, Issue:9

    Topics: Animals; Corticosterone; Dentate Gyrus; Excitatory Amino Acid Antagonists; Long-Term Potentiation; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Open Field Test; Perforant Pathway; Phenols; Piperidines; Quinolones; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Serine

2021
Geniposide attenuates postischemic long-term potentiation via GluN2A.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:3

    Topics: Animals; Apoptosis; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; Hydrogen Peroxide; Hypoxia-Ischemia, Brain; In Vitro Techniques; Infarction, Middle Cerebral Artery; Iridoids; Long-Term Potentiation; Neurons; Oxidants; PC12 Cells; Piperidines; Quinoxalines; Rats; Receptors, N-Methyl-D-Aspartate

2021