quinotrierixin has been researched along with thiazolyl-blue* in 1 studies
1 other study(ies) available for quinotrierixin and thiazolyl-blue
| Article | Year |
|---|---|
SAR study of a novel triene-ansamycin group compound, quinotrierixin, and related compounds, as inhibitors of ER stress-induced XBP1 activation.
In the course of screening for an inhibitor of ER stress-induced XBP1 activation, we isolated a new member of the triene-ansamycin group compound, quinotrierixin, from a culture broth of Streptomyces sp. PAE37. Quinotrierixin inhibited thapsigargin-induced XBP1 activation in HeLa cells with an IC50 of 0.067 microM. We found that other triene-ansamycin group compounds such as demethyltrienomycin A and mycotrienin I also inhibited ER stress-induced XBP1 activation. Moreover, we performed SAR study of twelve triene-ansamycin group compounds. The study showed that OH group at C-13 was crucial, and CH3 group at C-14 would be important for the XBP1 inhibitory activity. Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry, Physical; DNA-Binding Proteins; HeLa Cells; Humans; Luciferases; Magnetic Resonance Spectroscopy; Mass Spectrometry; Regulatory Factor X Transcription Factors; Reverse Transcriptase Polymerase Chain Reaction; Rifabutin; Streptomyces; Stress, Physiological; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Transcription Factors; X-Box Binding Protein 1 | 2008 |