Compounds > quinone methide
Page last updated: 2024-09-02

quinone methide and quercetin

quinone methide has been researched along with quercetin in 6 studies

Compound Research Comparison

Studies
(quinone methide)		Trials
(quinone methide)		Recent Studies (post-2010)
(quinone methide)		Studies
(quercetin)		Trials
(quercetin)		Recent Studies (post-2010) (quercetin)
374023212,4032397,510

Protein Interaction Comparison

ProteinTaxonomyquinone methide (IC50)quercetin (IC50)
Neuraminidase Influenza A virus (A/Wilson-Smith/1933(H1N1))2.2
hexokinaseTrypanosoma brucei brucei TREU92722.378
Maltase-glucoamylase, intestinalHomo sapiens (human)7.8
NUAK family SNF1-like kinase 1Homo sapiens (human)5.09
Lysine-specific histone demethylase 1AHomo sapiens (human)1.26
B2 bradykinin receptorCavia porcellus (domestic guinea pig)4
Arginase Leishmania amazonensis4
Epidermal growth factor receptorHomo sapiens (human)0.9
ProthrombinHomo sapiens (human)1.5
Cationic trypsinBos taurus (cattle)7.1
Beta-lactamaseEscherichia coli K-124
NeuraminidaseInfluenza A virus (A/Puerto Rico/8/1934(H1N1))7.75
Interstitial collagenaseHomo sapiens (human)1.49
Phospholipase A2Homo sapiens (human)2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1Oryctolagus cuniculus (rabbit)9
Cytochrome P450 1A1Homo sapiens (human)5.5455
Amyloid-beta precursor proteinHomo sapiens (human)7.94
MyeloperoxidaseHomo sapiens (human)1.6975
Cytochrome P450 1A2Homo sapiens (human)4.097
Cyclin-dependent kinase 1Homo sapiens (human)0.45
Glycogen phosphorylase, liver formHomo sapiens (human)4.8
Epoxide hydrolase 1 Homo sapiens (human)7
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)6.6417
Insulin-like growth factor 1 receptorHomo sapiens (human)0.3
Neutrophil elastaseHomo sapiens (human)22.378
72 kDa type IV collagenaseHomo sapiens (human)6.68
Stromelysin-1Homo sapiens (human)5.57
Hepatocyte growth factor receptorHomo sapiens (human)0.58
Cytochrome P450 3A4Homo sapiens (human)7
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiens (human)2.6975
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus8.1
Lysosomal alpha-glucosidaseHomo sapiens (human)7.8
SialidaseClostridium perfringens4.7333
Malate dehydrogenaseThermus thermophilus6
Cytochrome P450 2C8Homo sapiens (human)7
Serine/threonine-protein kinase pim-1Homo sapiens (human)0.7686
AromataseHomo sapiens (human)0.012
Polyunsaturated fatty acid 5-lipoxygenaseRattus norvegicus (Norway rat)1.95
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)0.43
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.12
Sucrase-isomaltase, intestinalHomo sapiens (human)7.8
Matrix metalloproteinase-9Homo sapiens (human)0.8919
Serine/threonine-protein kinase B-rafHomo sapiens (human)7.589
Aldo-keto reductase family 1 member B1Homo sapiens (human)2.2141
G2/mitotic-specific cyclin-BMarthasterias glacialis (spiny starfish)2.1
Polyunsaturated fatty acid lipoxygenase ALOX15Homo sapiens (human)2.2
Aldo-keto reductase family 1 member B1Bos taurus (cattle)2.85
Polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)0.44
Glycogen synthase kinase-3 betaRattus norvegicus (Norway rat)2.1
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)4
Casein kinase II subunit alpha'Homo sapiens (human)1.65
Amine oxidase [flavin-containing] AHomo sapiens (human)2.62
Amine oxidase [flavin-containing] A Bos taurus (cattle)0.01
C-X-C chemokine receptor type 1Homo sapiens (human)4.7559
Dipeptidyl peptidase 4Homo sapiens (human)2.92
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)3.8
Proteasome subunit beta type-5Homo sapiens (human)2.75
Vasopressin V2 receptorHomo sapiens (human)6.6548
Tyrosine-protein kinase receptor UFOHomo sapiens (human)0.96
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)1
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)5.39
Bifunctional epoxide hydrolase 2Homo sapiens (human)7
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.97
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.59
17-beta-hydroxysteroid dehydrogenase type 2Homo sapiens (human)1.54
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)1
Collagenase 3Homo sapiens (human)8.46
1-deoxy-D-xylulose 5-phosphate reductoisomeraseEscherichia coli K-121.9
Xanthine dehydrogenase/oxidaseHomo sapiens (human)3.04
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)3.8
Glycogen synthase kinase-3 alphaHomo sapiens (human)2.1
Glycogen synthase kinase-3 betaHomo sapiens (human)2.1
Aldo-keto reductase family 1 member A1Rattus norvegicus (Norway rat)2.32
C-C chemokine receptor type 4Homo sapiens (human)10
Serine/threonine-protein kinase Nek2Homo sapiens (human)5.73
Serine/threonine-protein kinase PLK1Homo sapiens (human)5.75
Death-associated protein kinase 1Homo sapiens (human)8.9
Mitogen-activated protein kinase 10Homo sapiens (human)2.88
Beta-secretase 1Homo sapiens (human)6.05
Casein kinase II subunit betaHomo sapiens (human)1.65
Casein kinase II subunit alphaHomo sapiens (human)1.65
LactoperoxidaseBos taurus (cattle)6.1
Cyclin-dependent kinase 6Homo sapiens (human)2.1
Cyclin-dependent-like kinase 5 Homo sapiens (human)2.1
Cyclin homologHerpesvirus saimiri (strain 11)2.1
Lactoylglutathione lyaseHomo sapiens (human)3.2
Focal adhesion kinase 1Homo sapiens (human)1.2
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)3
ELAV-like protein 3Homo sapiens (human)1.8
Cyclin-dependent kinase 5 activator 1Homo sapiens (human)2.1
ELAV-like protein 1Homo sapiens (human)1.4
Serine/threonine-protein kinase N1Homo sapiens (human)5.8
Mitogen-activated protein kinase 14Homo sapiens (human)2.88
Cytochrome P450 1B1Homo sapiens (human)1.1108
Probable maltase-glucoamylase 2Homo sapiens (human)7.8
Monocarboxylate transporter 2Rattus norvegicus (Norway rat)5
Integrase Human immunodeficiency virus 14.3
Casein kinase II subunit alpha 3Homo sapiens (human)0.55
Inositol polyphosphate multikinaseHomo sapiens (human)2.3
Aldo-keto reductase family 1 member C21Mus musculus (house mouse)6.9
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)1.8333
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)5.4
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)1.5
Aurora kinase BHomo sapiens (human)2.435
Cyclin-dependent kinase 1Oryzias latipes (Japanese medaka)2.1
Serine/threonine-protein kinase Nek6Homo sapiens (human)4.23
NADPH oxidase 4Homo sapiens (human)0.68
Inositol hexakisphosphate kinase 2Homo sapiens (human)0.7
Short transient receptor potential channel 5Homo sapiens (human)6.5
ALK tyrosine kinase receptorHomo sapiens (human)3.32
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)7.25

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boersma, MG; Cenas, N; Lemanska, K; Rietjens, IM; Segura-Aguilar, J; Szymusiak, H; Tyrakowska, B; Vervoort, J1
Awad, HM; Boersma, MG; Rietjens, IM; Van Bladeren, PJ; van Iersel, ML; Vervoort, J1
Awad, HM; Boeren, S; Boersma, MG; Rietjens, IM; van Bladeren, PJ; Vervoort, J2
Awad, HM; Boeren, S; Boersma, MG; Rietjens, IM; van Bladeren, PJ; van der Woude, H; van Zanden, J; Vervoort, J1
Cabezas-Herrera, J; Chazarra, S; Rodríguez-López, JN; Sáez-Ayala, M; Sánchez-Del-Campo, L1

Other Studies

6 other study(ies) available for quinone methide and quercetin

ArticleYear
Regioselectivity and reversibility of the glutathione conjugation of quercetin quinone methide.
    Chemical research in toxicology, 2000, Volume: 13, Issue:3

    Topics: Chromatography, High Pressure Liquid; Glutathione; Indolequinones; Indoles; Magnetic Resonance Spectroscopy; Quercetin; Quinones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2000
Structure activity relationships for the chemical behaviour and toxicity of electrophilic quinones/quinone methides.
    Advances in experimental medicine and biology, 2001, Volume: 500

    Topics: Benzoquinones; Flavonoids; Flavonols; Glutathione; HL-60 Cells; Humans; Indolequinones; Indoles; Luteolin; Molecular Structure; Mutagens; Oxidants; Quercetin; Quinones; Salmonella typhimurium; Structure-Activity Relationship

2001
The regioselectivity of glutathione adduct formation with flavonoid quinone/quinone methides is pH-dependent.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: Chromatography, High Pressure Liquid; Flavonoids; Flavonols; Glutathione; Hydrogen-Ion Concentration; Indolequinones; Indoles; Luteolin; Magnetic Resonance Spectroscopy; Mass Spectrometry; Quercetin; Quinones

2002
Identification of o-quinone/quinone methide metabolites of quercetin in a cellular in vitro system.
    FEBS letters, 2002, Jun-05, Volume: 520, Issue:1-3

    Topics: Animals; Benzoquinones; Chromatography, High Pressure Liquid; Glutathione; Indolequinones; Indoles; Mass Spectrometry; Molecular Structure; Monophenol Monooxygenase; Quercetin; Quinones; Tumor Cells, Cultured

2002
Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation.
    Chemical research in toxicology, 2003, Volume: 16, Issue:7

    Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Cysteine; Glutathione; Indolequinones; Magnetic Resonance Spectroscopy; Monophenol Monooxygenase; Oxidation-Reduction; Quercetin; Quinones; Sulfhydryl Compounds

2003
Binding of natural and synthetic polyphenols to human dihydrofolate reductase.
    International journal of molecular sciences, 2009, Dec-18, Volume: 10, Issue:12

    Topics: Amino Acid Sequence; Binding Sites; Catechin; Folic Acid Antagonists; Glucuronides; Humans; Indolequinones; Molecular Docking Simulation; Molecular Sequence Data; Polyphenols; Protein Binding; Quercetin; Tetrahydrofolate Dehydrogenase

2009