Compounds > quinone methide
Page last updated: 2024-09-02

quinone methide and afimoxifene

quinone methide has been researched along with afimoxifene in 4 studies

Compound Research Comparison

Studies
(quinone methide)		Trials
(quinone methide)		Recent Studies (post-2010)
(quinone methide)		Studies
(afimoxifene)		Trials
(afimoxifene)		Recent Studies (post-2010) (afimoxifene)
37402321,25510325

Protein Interaction Comparison

ProteinTaxonomyquinone methide (IC50)afimoxifene (IC50)
Phospholipase D2Homo sapiens (human)6.5
Estrogen receptorHomo sapiens (human)0.0105
Estrogen-related receptor gammaHomo sapiens (human)0.0084
Phospholipase D1Homo sapiens (human)6.5
Estrogen receptor betaHomo sapiens (human)0.0102

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Beland, FA; Marques, MM1
Bolton, JL; Fan, PW; Zhang, F1
Bolton, JL; van Breemen, RB; Yang, Y; Yao, D; Yu, L; Zhang, F1
D'Agostino, J; Hollenberg, PF; Sridar, C1

Other Studies

4 other study(ies) available for quinone methide and afimoxifene

ArticleYear
Identification of tamoxifen-DNA adducts formed by 4-hydroxytamoxifen quinone methide.
    Carcinogenesis, 1997, Volume: 18, Issue:10

    Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; Indolequinones; Indoles; Quinones; Salmon; Spectrometry, Mass, Fast Atom Bombardment; Tamoxifen

1997
4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
    Chemical research in toxicology, 2000, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytochrome P-450 Enzyme System; Estrogen Receptor Modulators; Female; Glutathione; Humans; Hydroxylation; Indolequinones; Indoles; Mass Spectrometry; Oxidation-Reduction; Quinones; Rats; Rats, Sprague-Dawley; Tamoxifen; Toremifene; Tumor Cells, Cultured

2000
Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
    Chemical research in toxicology, 2001, Volume: 14, Issue:12

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Breast Neoplasms; Cell Survival; Deoxyribonucleosides; DNA Adducts; Female; Glutathione; Indolequinones; Indoles; Microsomes, Liver; Quinones; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tamoxifen; Toremifene; Tumor Cells, Cultured

2001
Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Apoproteins; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP2B6; Glutathione; Humans; Hydroxylation; Indolequinones; Microsomes, Liver; Oxidoreductases, N-Demethylating; Tamoxifen

2012