Page last updated: 2024-09-02

quinone methide and 4-hydroxytoremifene

quinone methide has been researched along with 4-hydroxytoremifene in 2 studies

Compound Research Comparison

Studies
(quinone methide)
Trials
(quinone methide)
Recent Studies (post-2010)
(quinone methide)
Studies
(4-hydroxytoremifene)
Trials
(4-hydroxytoremifene)
Recent Studies (post-2010) (4-hydroxytoremifene)
37402321213

Protein Interaction Comparison

ProteinTaxonomyquinone methide (IC50)4-hydroxytoremifene (IC50)
Estrogen receptorHomo sapiens (human)0.007
Estrogen-related receptor gammaHomo sapiens (human)0.01

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bolton, JL; Fan, PW; Zhang, F1
Bolton, JL; van Breemen, RB; Yang, Y; Yao, D; Yu, L; Zhang, F1

Other Studies

2 other study(ies) available for quinone methide and 4-hydroxytoremifene

ArticleYear
4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
    Chemical research in toxicology, 2000, Volume: 13, Issue:1

    Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytochrome P-450 Enzyme System; Estrogen Receptor Modulators; Female; Glutathione; Humans; Hydroxylation; Indolequinones; Indoles; Mass Spectrometry; Oxidation-Reduction; Quinones; Rats; Rats, Sprague-Dawley; Tamoxifen; Toremifene; Tumor Cells, Cultured

2000
Synthesis and reactivity of potential toxic metabolites of tamoxifen analogues: droloxifene and toremifene o-quinones.
    Chemical research in toxicology, 2001, Volume: 14, Issue:12

    Topics: Animals; Antineoplastic Agents; Benzoquinones; Breast Neoplasms; Cell Survival; Deoxyribonucleosides; DNA Adducts; Female; Glutathione; Indolequinones; Indoles; Microsomes, Liver; Quinones; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tamoxifen; Toremifene; Tumor Cells, Cultured

2001