quinolinic acid has been researched along with tryptophan in 271 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (7.38) | 18.7374 |
| 1990's | 61 (22.51) | 18.2507 |
| 2000's | 54 (19.93) | 29.6817 |
| 2010's | 84 (31.00) | 24.3611 |
| 2020's | 52 (19.19) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Anegawa, NJ; Batshaw, ML; Djali, S; Gorry, E; Heyes, MP; Mellits, ED; Robinson, MB | 1 |
| Pewnim, T; Seifert, J | 1 |
| Heyes, MP; Jacobowitz, D; Markey, SP; Saito, K; Takikawa, O; Vickers, JH | 1 |
| Fuchs, D; Reibnegger, G; Wachter, H; Weiss, G; Werner-Felmayer, G | 1 |
| Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM | 1 |
| Heyes, MP; Markey, SP; Saito, K | 3 |
| Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE | 1 |
| Frank, JA; Gravell, M; Heyes, MP; Jordan, EK; Lee, K; Markey, SP; Saito, K; Snoy, PJ | 1 |
| Carlà, V; De Luca, G; Moroni, F; Politi, V; Russi, P | 1 |
| Morgan, PF | 1 |
| Auer, RN; Heyes, MP; Leonard, C; Markey, SP; Papagapiou, M | 2 |
| Heyes, MP; Nowak, TS | 1 |
| Heyes, MP; Quearry, BJ | 1 |
| Boni, RL; Heyes, MP; Markey, SP; Yergey, JA | 1 |
| Connick, JH; Hall, E; Lombardi, G; Moroni, F; Stone, TW; Taylor, A | 1 |
| Abramson, FP; Bacher, JD; Boni, RL; Heyes, MP; Ji, XD; Markey, SP; Yergey, JA | 1 |
| During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Matson, WR; Roth, RH; Swartz, KJ | 1 |
| Murata, K; Shibata, K | 1 |
| April, M; Blackmore, D; Eckhaus, M; Gravell, M; Heyes, MP; London, WT; Markey, SP; Vickers, JH; Yergey, JA | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K | 1 |
| Cotton, P | 1 |
| Beninger, RJ; Bialik, M; Boegman, RJ; Jhamandas, K | 1 |
| Dedhia, M; Heyes, MP; Lackner, A; Mefford, IN; Quearry, BJ | 1 |
| Bird, SJ; Culligan, NW; Edelsohn, L; Garcia, CA; Heiman-Patterson, TD; Heyes, MP; Parry, GJ; Shy, ME; Tatarian, GT; Varga, J | 1 |
| Carassale, GL; Carlà, V; Cortesini, C; Lombardi, G; Moroni, F; Pellegrini, D | 1 |
| Carlà, V; Etienne, P; Lal, S; Lombardi, G; Moroni, F; Nair, NP | 1 |
| Heyes, MP; Markey, SP; Quearry, BJ | 1 |
| During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Roth, RH | 1 |
| During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Roth, RH; Swartz, KJ | 1 |
| Kiyohara, Y; Sano, K; Shin, M; Shirasawa, K; Umezawa, C | 1 |
| Heyes, MP; Lane, C; Markey, SP; Rubinow, D | 1 |
| Schwarcz, R; Speciale, C; Ungerstedt, U | 1 |
| Hayakawa, T; Iwai, K; Murata, K; Shibata, K | 1 |
| Dykens, JA; Stern, A; Sullivan, SG | 1 |
| Heyes, MP; Kim, P; Markey, SP | 1 |
| Carlà, V; Lombardi, G; Moroni, F | 1 |
| Heyes, MP; Markey, SP | 1 |
| Shibata, Y; Takeuchi, F; Tsubouchi, R | 1 |
| Barrett, J; Lloyd, GM | 1 |
| Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA | 1 |
| Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K | 1 |
| Boni, RL; Markey, SP; Naritsin, DB | 1 |
| Bingel, SA; Hampton, M; Harley, RA; Heyes, MP; Ludwicka, A; Maize, J; Ohba, T; Silver, RM; Smith, T | 1 |
| Crowley, JS; Heyes, MP; Markey, SP; Nowak, TS; Quearry, BJ; Saito, K; Saito, M; Suyama, K | 1 |
| Pascoe, M | 1 |
| Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH | 1 |
| Kitoh, J; Kuroda, T; Masuda, K; Mizobuchi, M; Nakano, K; Takahashi, S | 1 |
| Heyes, MP; Markey, SP; Nowak, TS; Saito, K | 1 |
| Chen, CY; Crowley, JS; Heyes, MP; Markey, SP; Masana, M; Saito, K | 1 |
| Flanagan, EM; Iyer, R; Madge, DJ; Reinhard, JF; Salter, M | 1 |
| Giulian, D; Li, J; Li, X; Lin, SN; Noonan, C; Schwarcz, R; Tom, D; Wendt, E; Yu, J | 1 |
| Espey, MG; Gajdusek, DC; Gibbs, CJ; Moffett, JR; Namboodiri, MA; Narayanan, R; Venkateshan, CN | 1 |
| Heyes, MP; Klipple, GL; Lipnick, RN; Salazar, AM; Sfikakis, PP; Tsokos, GC; Vogelgesang, SA; West, SG | 1 |
| Batshaw, ML; Heyes, MP; Hopkins, K; McLaughlin, BA; Oster-Granite, ML; Robinson, MB | 1 |
| Apelqvist, G; Bengtsson, F; Bergqvist, PB; Butterworth, RF; Heyes, MP | 1 |
| Fuchs, D; Gisslén, M; Hagberg, L; Larsson, M; Norkrans, G; Wachter, H | 1 |
| Fornstedt-Wallin, B; Fredriksson, G; Luthman, J; Vänerman, E | 1 |
| Bengtsson, F; Bergqvist, PB; Heyes, MP | 1 |
| Blinder, K; Gajdusek, DC; Gibbs, CJ; Gravell, M; Moffett, JR; Namboodiri, AM; Narayanan, R; Venkateshan, CN | 1 |
| Achim, CL; Heyes, MP; Major, EO; Markey, SP; Saito, K; Wiley, CA | 1 |
| Klein, TL; Lunte, SM; Malis, M; Palmer, SD; Weber, PL | 1 |
| Armati, PJ; Brew, BJ; Kerr, SJ; Pemberton, LA; Smythe, G; Tattam, B | 1 |
| Dong-Ryul, L; Furukawa, S; Kondo, H; Nakano, K | 1 |
| Chaudhri, G; Hunt, NH; Moore, DE; Sanni, LA; Stocker, R; Tattam, BN; Thomas, SR | 1 |
| Reinhard, JF | 1 |
| Dong-Ruyl, L; Nakano, K; Sawada, M | 1 |
| Blinder, KL; Moffett, JR; Namboodiri, MA; Venkateshan, CN | 1 |
| Goodman, CB; Heyliger, SO; Ngong, JM; Soliman, KF | 1 |
| Block, E; Burchard, JF; Heyes, MP; Nguyen, DH; Richard, L; Young, SN | 1 |
| Grant, RS; Kapoor, V; Matanovic, G; Passey, R; Smythe, G | 1 |
| Fornstedt-Wallin, B; Fredriksson, G; Lundström, J; Luthman, J; Schwarcz, R | 1 |
| Bengtsson, F | 1 |
| Crawley, J; Dobbie, M; Marsh, K; Surtees, R; Waruiru, C | 1 |
| Stone, TW | 1 |
| Allen, RH; Altfeld, M; Kreuzer, KA; Look, MP; Riezler, R; Rockstroh, JK; Sauerbruch, T; Stabler, SP | 1 |
| Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H | 1 |
| Brown, OR; Dale, WE; Dang, Y | 1 |
| Arun, P; Deepadevi, KV; Kurup, PA; Manojkumar, V; Ravikumar, A | 1 |
| Baraldi, M; Cannazza, G; Zanoli, P | 1 |
| Fukuwatari, T; Shibata, K; Sugimoto, E | 1 |
| Nicholls, T; Nitsos, I; Smythe, G; Walker, DW | 1 |
| Calvani, M; Chiarugi, A; Meli, E; Moroni, F; Traggiai, E | 1 |
| Fukuwatari, T; Hayakawa, F; Morikawa, Y; Shibata, K; Sugimoto, E | 1 |
| Bjugstad, KB; Freed, CR; Goodman, S; Zawada, WM | 1 |
| Buczko, W; Pawlak, D; Tankiewicz, A | 1 |
| Buczko, W; Mysliwiec, P; Pawlak, D; Tankiewicz, A | 1 |
| Buczko, W; Myśliwiec, M; Myśliwiec, P; Pawlak, D | 1 |
| Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Heyes, MP; Kita, T; Markey, SP; Morrison, PF | 1 |
| Egashira, Y; Fukuoka, S; Ishiguro, K; Sanada, H; Shibata, K; Tanabe, A; Yanagihara, K | 1 |
| Fukuwatari, T; Morikawa, Y; Shibata, K; Sugimoto, E | 1 |
| Dayrell-Hart, B; Djali, S; Drobatz, KJ; Heyes, MP; Holt, DE; Robinson, MB; Washabau, RJ | 1 |
| Bianchi, R; Fallarino, F; Fioretti, MC; Grohmann, U; Orabona, C; Puccetti, P; Spreca, A; Vacca, C | 1 |
| Brew, BJ; Guillemin, GJ | 1 |
| Fukuwatari, T; Shibata, K; Sugimoto, E; Suzuki, Y | 1 |
| Kurup, PA; Kurup, RK | 1 |
| Moffett, JR; Namboodiri, MA | 1 |
| Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW | 1 |
| Bwanaisa, L; Day, NP; Hunt, NH; Kayira, K; Medana, IM; Njobvu, A; Salahifar-Sabet, H; Smythe, G; Stocker, R; Taylor, TE; Turner, GD | 1 |
| HENDERSON, LM; WILSON, RG | 1 |
| Cerstiaens, A; De Loof, A; Huybrechts, J; Kotanen, S; Lebeau, I; Meylaers, K; Schoofs, L | 1 |
| Anantha, S; Begley, TP; Colabroy, K; Gerdes, S; Goral, V; Kurnasov, O; Osterman, A | 1 |
| Asano, E; Chakraborty, PK; Chugani, DC; Chugani, HT; Juhász, C; Mangner, TJ; Muzik, O; Padhye, UN; Shah, A; Sood, S | 1 |
| Fukuwatari, T; Sasaki, R; Shibata, K; Wada, H | 1 |
| HENDERSON, LM; SCHAYER, RW | 1 |
| Fukuwatari, T; Kitamura, J; Ohta, M; Sasaki, R; Shibata, K | 1 |
| Egashira, Y; Fukuoka, S; Fukuwatari, T; Ishiguro, K; Sanada, H; Shibata, K; Tanabe, A | 1 |
| Fukuoka, S; Fukuwatari, T; Ohsaki, S; Sasaki, R; Shibata, K | 1 |
| Cai, T; Chen, A; Di Prospero, NA; Du, F; Guidetti, P; Melendez-Ferro, M; Sapko, MT; Schwarcz, R; Tagle, DA; Whetsell, WO; Yu, P | 1 |
| Rho, JM | 1 |
| HENDERSON, LM; HIRSCH, HM | 1 |
| HENDERSON, LM; JOHNSON, BC; RAMASARMA, GB | 1 |
| Egashira, Y; Morise, A; Murotani, G; Saito, K; Sanada, H; Sato, M; Tanabe, A; Uehara, K | 1 |
| Brown, AR; Kranz, DM; Roy, EJ; Takikawa, O; Thomas, DL | 1 |
| Noakes, R; Spelman, L; Williamson, R | 1 |
| Perez-De La Cruz, V; Santamaria, A | 1 |
| Bale, S; Begley, TP; Crane, BR; Ealick, SE; Kang, SA; Mukherjee, T; Zhang, Y | 1 |
| Cimadamore, F; Orsomando, G; Perozzi, S; Pucci, L; Raffaelli, N | 1 |
| Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N | 1 |
| Egashira, Y; Saito, K; Sanada, H; Sato, M | 1 |
| Bosmans, E; Kubera, M; Maes, M; Mihaylova, I; Ruyter, MD | 1 |
| HENDERSON, LM | 1 |
| Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J | 1 |
| Fukuwatari, T; Shibata, K | 2 |
| Fotopoulou, C; Hasper, D; Pschowski, R; Reinke, P; Schefold, JC; Schuett, C; Volk, HD; von Haehling, S; Zeden, JP | 1 |
| Egashira, Y; Sanada, H; Sasaki, N | 1 |
| Guidetti, P; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Fukuwatari, T; Kurata, K; Shibata, K | 1 |
| Fülöp, F; Klivényi, P; Toldi, J; Vámos, E; Vécsei, L; Zádori, D | 1 |
| Buczko, W; Dadan, J; Myśliwiec, H; Myśliwiec, P; Pawlak, D; Pawlak, K | 1 |
| Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Dantzer, R; Kelley, KW; Lawson, MA; Miller, AH; Raison, CL; Saito, K; Spivey, JR; Vogt, G; Woolwine, BJ | 1 |
| Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R | 1 |
| Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP | 1 |
| Chen, Y; Guillemin, GJ; Meininger, V | 1 |
| Kincses, ZT; Toldi, J; Vécsei, L | 1 |
| Bien, B; Gulaj, E; Pawlak, D; Pawlak, K | 1 |
| Bieber, T; Brenk, M; Koch, S; Scheler, M; von Bubnoff, D; Wilms, H | 1 |
| Bernstein, HG; Bielau, H; Bogerts, B; Brisch, R; Gos, T; Guillemin, GJ; Mawrin, C; Meyer zu Schwabedissen, L; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M | 1 |
| Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H | 1 |
| Ammer, J; Andreesen, R; Edinger, M; Holler, B; Holler, E; Kreutz, M; Landfried, K; Oefner, PJ; Peter, K; Schulz, U; Waldhier, MC; Wolff, D; Zhu, W | 1 |
| Azechi, H; Board, M; Yamamoto, T | 1 |
| Du Preez, JL; Emsley, R; Harvey, BH; Möller, M | 1 |
| Du Preez, JL; Harvey, BH; Möller, M | 1 |
| Tan, L; Yu, JT | 1 |
| Darlington, LG; Stone, TW; Stoy, N | 1 |
| Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ | 1 |
| Fukuwatari, T; Kondo, R; Sano, M; Shibata, K | 1 |
| Adams, S; Ahrendt, T; Bode, HB; Guillemin, GJ; Oezen, I; Opitz, CA; Platten, M; Radlwimmer, B; Sahm, F; von Deimling, A; Wick, W | 1 |
| Fukuwatari, T; Funakoshi, H; Kadota, E; Kanai, M; Nakamura, T; Sano, M; Shibata, K; Terakata, M | 1 |
| Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES | 1 |
| Dijkhuis, A; Johnston, SL; Karlas, JA; Kulik, W; Lutter, R; Molenkamp, R; Smids, BS; Sterk, PJ; van de Pol, MA; van der Sluijs, KF; van der Zee, JS; van Eijk, HW; Wolthers, KC | 1 |
| Bergareche, A; Buxbaum, JD; Gorostidi, A; López de Munain, A; Makarov, V; Martí-Massó, JF; Paisán-Ruiz, C; Poza, JJ; Ruiz-Martinez, J; Striano, P | 1 |
| Fukuwatari, T; Morita, N; Shibata, K; Shibata, Y | 1 |
| Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH | 1 |
| Aguesse, A; Castellano, B; Darmaun, D; Ferchaud-Roucher, V; Nael, C; Poupeau, G; Sano, M | 1 |
| Banister, SD; Guillemin, GJ; Karl, T; Kassiou, M; Lim, CK; Purves-Tyson, T; Weickert, CS; Zavitsanou, K | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Adams, S; Braidy, N; Brew, BJ; Bustamante, S; Guillemin, GJ; Lim, CK; McDonald, KL; Sundaram, G; Teo, C; Zinger, A | 1 |
| Andreassen, OA; Brundin, L; Dahl, J; Malt, UF; Ormstad, H; Sandvik, L; Verkerk, R | 1 |
| Drewes, JL; Gama, L; Graham, DR; Li, M; Liao, Z; Meulendyke, KA; Notarangelo, FM; Schwarcz, R; Tarwater, PM; Ubaida-Mohien, C; Witwer, KW; Zink, MC | 1 |
| Bertuch, AA; Polleys, EJ | 1 |
| Elizondo, G; García-Lara, L; González-Esquivel, D; Pérez-Severiano, F; Segovia, J | 1 |
| Frugier, T; Guillemin, GJ; Heng, B; Lim, CK; Morganti-Kossmann, MC; Rosenfeld, JV; Sundaram, G; Tan, M; Walker, DW; Yan, EB | 1 |
| Budac, DP; Elfving, B; Eskelund, A; Fischer, CW; Liebenberg, N; Tillmann, S; Wegener, G | 1 |
| Bipath, P; Levay, PF; Viljoen, M | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Buttar, HS; Nayak, BN | 1 |
| de Bie, J; Grant, R; Guest, J; Guillemin, GJ | 1 |
| Kaminski, T; Michalowska, M; Oksztulska-Kolanek, E; Pawlak, D; Znorko, B | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M | 1 |
| Budac, DP; Elfving, B; Eskelund, A; Sanchez, C; Wegener, G | 1 |
| Braidy, N; Brew, BJ; Guillemin, GJ; Lee, JM; Lovejoy, D; Rowe, DB; Tan, V | 1 |
| Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R | 1 |
| Allorge, D; Caiazzo, R; Favennec, M; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Raverdy, V; Verbanck, M; Verkindt, H; Yengo, L | 1 |
| Bezard, E; Camus, SM; Ceci, A; Fuertig, R; Hengerer, B; Luippold, AH | 1 |
| Bhat, M; Erhardt, S; Orhan, F; Piehl, F; Sandberg, K; Schwieler, L; Ståhl, S; Svensson, C | 1 |
| Al-Dhabi, NA; Bai, M; Duraipandiyan, V; Liu, G; Liu, H; Oso, AO; Tossou, MC; Wu, X; Xi, Q; Xu, K; Yin, Y | 1 |
| Bhat, M; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, ME; Landén, M; Schuppe-Koistinen, I; Schwieler, L; Wetterberg, L | 1 |
| Gabriele, S; Gevi, F; Persico, AM; Zolla, L | 1 |
| Chiang, IT; Chiou, TW; Harn, HJ; Hsieh, DK; Lin, SY; Lin, SZ; Liu, JW; Rajamani, K; Wu, CH; You, DH | 1 |
| Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Kapfhammer, HP; Maget, A; Mangge, H; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, B; Reininghaus, EZ; Schütze, G; Schwarz, M; Zelzer, S | 1 |
| Anderson, G; Carvalho, AF; Geffard, M; Kanchanatawan, B; Maes, M; Ruxrungtham, K; Sirivichayakul, S | 1 |
| Ablasser, K; Alesutan, I; Belyavskiy, E; Brussee, H; Catena, C; Fahrleitner-Pammer, A; Grübler, MR; Kolesnik, E; Lewinski, DV; März, W; Meinitzer, A; Pieske, B; Pieske-Kraigher, E; Pilz, S; Schwetz, V; Sechi, LA; Tomaschitz, A; Trummer, C; Verheyen, N; Voelkl, J | 1 |
| Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z | 1 |
| Hanna-Rose, W; Holleran, LM; McReynolds, MR; Wang, W | 1 |
| Parasram, K | 1 |
| Leonard, BE | 1 |
| Aden, K; Al-Massad, N; Bethge, J; Häsler, R; Krawczak, M; Moll, N; Nikolaus, S; Rehman, A; Rosenstiel, P; Schreiber, S; Schulte, B; Schulte, DM; Schütze, G; Schwarz, MJ; Szymczak, S; Thieme, F; Tran, F; Waetzig, GH | 1 |
| Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A | 1 |
| Makino, R; Okuyama, H; Tachibana, T; Tomonaga, S | 1 |
| Czarny, P; Galecki, P; Sliwinski, T; Wigner, P | 1 |
| Chen, B; Guo, J; He, S; Hu, J; Hu, L; Huang, X; Li, X; Qi, Y; Shang, D; Wang, J; Wen, Y | 1 |
| Duan, KM; Huang, Z; Ma, JH; Wang, SY; Yu, H; Zhou, Y | 1 |
| Arnhard, K; Fuchs, D; Koal, T; Oberacher, H; Pitterl, F; Sperner-Unterweger, B | 1 |
| Bryn, V; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Shibata, K | 1 |
| Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H | 1 |
| Cline, MA; Kadomoto, Y; Khan, MSI; Makino, R; Tachibana, T | 1 |
| Allers, KA; Doolin, K; Farrell, C; Frodl, T; Harkin, A; Liesener, A; O'Hanlon, E; O'Keane, V; Pleiner, S; Roddy, D; Tozzi, L | 1 |
| Arnone, D; Dantzer, R; Salem, H; Saraykar, S; Selvaraj, S; Teixeira, AL | 1 |
| Kanchanatawan, B; Maes, M | 1 |
| Bryn, V; Halvorsen, B; Isaksen, J; Maes, M; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Badawy, AA | 1 |
| Botticelli, A; Cerbelli, B; Federica, M; Lionetto, L; Marchetti, P; Nuti, M; Pisano, A; Salati, M; Simmaco, M; Zizzari, I | 1 |
| Atzori, M; García-Oscos, F; Pérez-Padilla, EA; Pineda, JC; Ramírez, LA; Salgado, H | 1 |
| Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y | 1 |
| Carrillo Mora, P; García Muñoz, I; García-Juárez, B; Gómez-Manzo, S; González-Esquivel, D; Jiménez Herrera, B; Marcial-Quino, J; Pérez de la Cruz, G; Pérez de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Ramos-Chávez, LA; Ríos, C; Roldán-Roldán, G; Sánchez Chapul, L | 1 |
| Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M | 1 |
| Böhmová, A; Horáček, J; Kodym, P; Krsek, D; Mikoška, M; Syslová, K; Tejkalová, H; Vacek, L; Vondroušová, J | 1 |
| Chabielska, E; Kamiński, T; Kramkowski, K; Leszczyńska, A; Marcińczyk, N; Misztal, T; Pawlak, D | 1 |
| Bhat, M; Blennow, K; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, M; Landén, M; Schwieler, L; Wetterberg, L; Zetterberg, H | 1 |
| Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R | 1 |
| Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H | 1 |
| Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM | 1 |
| Bloch, W; Hardt, L; Joisten, N; Kiesl, D; Knoop, A; Koliamitra, C; Kummerhoff, F; Metcalfe, AJ; Schenk, A; Thevis, M; Walzik, D; Zimmer, P | 1 |
| Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R | 1 |
| Cseh, EK; Janáky, T; Kecskeméti, G; Kormány, R; Rajda, C; Szabó, E; Szabó, Z; Tömösi, F; Vécsei, L | 1 |
| Coppens, V; De Picker, L; Kampen, JK; Morrens, M | 1 |
| Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS | 1 |
| Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C; Misiak, B; Savitz, JB | 1 |
| Gökmen, V; Yılmaz, C | 1 |
| Cao, B; Chen, Y; McIntyre, RS; Pan, Z; Ren, Z; Wang, D | 1 |
| Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM | 1 |
| Chiappelli, J; Cui, Y; Hong, LE; Huang, J; Kochunov, P; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y | 1 |
| Cathomas, F; Guetter, K; Kaiser, S; Klaus, F; Seifritz, E | 1 |
| Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y | 1 |
| Hoffman, WH; Lee, N; Whelan, SA | 1 |
| Braidy, N; Guillemin, GJ; Joisten, N; Ruas, JL; Zimmer, P | 1 |
| Janczarek, I; Kędzierski, W; Kowalik, S; Sadok, I; Staniszewska, M | 1 |
| Bou Khalil, R; El Khoury, R | 1 |
| Ciapała, K; Mika, J; Rojewska, E | 1 |
| Anderson, EW; Aranow, C; Diamond, B; Fishbein, J; Furie, RA; Hong, J; Mackay, M; Roeser, J; Volpe, BT | 1 |
| Anglicheau, D; Bignon, Y; Cippà, PE; Fohlen, B; Galichon, P; Hertig, A; Karras, A; Lenoir, O; Nadour, Z; Naesens, M; Nemazanyy, I; Pallet, N; Poindessous, V; Rinaldi, A; Weill-Raynal, P | 1 |
| Bugiani, M; Dijkhuis, A; Duitman, JW; Geeraerts, Z; Guo, L; Lutter, R; Nossent, EJ; Roos, E; Schurink, B; van der Valk, P; van Vught, L; Vaz, FM; Vlaar, AP; Yeh, SR | 1 |
| Brew, BJ; Guillemin, GJ; Heng, B; Krishnamurthy, S; Pires, AS; Sundaram, G | 1 |
| Kurzepa, J; Parada-Turska, J; Wnorowska, S; Wnorowski, A | 1 |
| Fukushima, T; Onozato, M; Sakamoto, T; Umino, M | 1 |
| Altunçekiç Yıldırım, A; Ceran Serdar, C; Cihan, M; Doğan, Ö; Kurt, C; Serdar, MA | 1 |
| Chen, J; Dang, E; Fang, H; Fu, M; Li, Q; Luo, Y; Ma, J; Qiao, P; Shao, S; Wang, G; Yin, W; Yu, J; Zhang, C; Zhang, J; Zhi, D | 1 |
| Al-Hakeim, HK; Almulla, AF; Maes, M; Solmi, M; Tunvirachaisakul, C; Vasupanrajit, A; Verkerk, R | 1 |
| Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA | 1 |
| Abusoglu, S; Eryavuz Onmaz, D; Kuzu, M; Sivrikaya, A; Tezcan, D; Unlu, A; Yerlikaya, FH; Yilmaz, S | 1 |
| Li, R; Long, X; Mu, L; Qiao, J; Wang, S; Zhang, C; Zhang, Y; Zhao, Y | 1 |
| Aaseth, JO; Alexander, J; Hestad, K; Rootwelt, H | 1 |
| Arnhard, K; Fuchs, D; Geisler, S; Gleissenthall, GV; Kemmler, G; Mechtcheriakov, S; Oberacher, H; Schurr, T; Unterberger, C | 1 |
| Asakawa, T; Chen, W; Jia, X; Qin, W; Shi, Y | 1 |
| Andrea, G; Cristina, B; Fabio, T; Luca, P; M C, BJ; Nicoletta, B; Sara, C; Silvia, A; Silvio, B; Veronica, R | 1 |
| Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J | 1 |
| Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO | 1 |
| An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W | 1 |
| Anderson, EW; Aranow, C; Arazi, A; Diamond, B; Furie, RA; Goodwin, S; Jin, Y; Mackay, M; Roeser, J; Shih, A; Volpe, B | 1 |
| Fathi, M; Hajiesmaeili, M; Jazi, K; Klegeris, A; Mafi, Z; McElhinney, A; Mohamadkhani, A; Sayehmiri, F; Tavasol, A; Vakili, K; Yaghoobpoor, S | 1 |
| Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM | 1 |
| Benninga, MA; Boneh, RS; de Jonge, WJ; Emond, P; Ghiboub, M; Lefèvre, A; Sovran, B; Van Limbergen, JE; Verburgt, CM; Wine, E | 1 |
| Buelow, KL; Chinnaiyan, P; Kant, S; Kesarwani, P; Miller, CR; Prabhu, A; Zhao, Y | 1 |
| Ahmad, NS; Embong, H; Makpol, S; Nasaruddin, ML; Phing, AH; Wan Zaidi, WA | 1 |
| Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J | 1 |
| Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M | 1 |
| Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y | 1 |
| Abusoglu, S; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Unlu, A | 1 |
| Ciampa, EJ; Clark, AJ; Etzrodt, V; Flores, BM; Huang, H; Parikh, SM; Saade, MC; Takakura, A; Vemireddy, V; Vu, KQ; Zandi-Nejad, K; Zsengellér, ZK | 1 |
| Baranyi, A; Enko, D; Herrmann, M; Meinitzer, A; Michaelis, S; Schnedl, WJ; Schneider, C; Zelzer, S | 1 |
| Mangoni, AA; Zinellu, A | 1 |
38 review(s) available for quinolinic acid and tryptophan
| Article | Year |
|---|---|
Mass spectrometric determinations of tryptophan and its metabolites.
Topics: Animals; Body Fluids; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Melatonin; Molecular Structure; Nervous System Diseases; Pineal Gland; Quinolinic Acid; Quinolinic Acids; Schizophrenia; Serotonin; Tryptophan | 1991 |
Brain tryptophan/serotonin perturbations in metabolic encephalopathy and the hazards involved in the use of psychoactive drugs.
Topics: Animals; Brain; Hepatic Encephalopathy; Humans; Indoles; Psychotropic Drugs; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptamines; Tryptophan | 1999 |
Endogenous neurotoxins from tryptophan.
Topics: Animals; Humans; Kynurenine; Nervous System Diseases; Neurotoxins; Quinolinic Acid; Tryptophan | 2001 |
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2002 |
Tryptophan and the immune response.
Topics: Animals; Dendritic Cells; Dioxygenases; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxygenases; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; Kynurenine; Quinolinic Acid; Tryptophan | 2003 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan | 2004 |
Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
Topics: Animals; Calcium; Cell Death; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acids; Humans; Huntington Disease; Inflammation; Kynurenic Acid; Mice; Mice, Transgenic; Mutation; Neurons; Nitro Compounds; Oxidative Stress; Propionates; Quinolinic Acid; Serotonin Plasma Membrane Transport Proteins; Trinucleotide Repeats; Tryptophan | 2007 |
Tryptophan, adenosine, neurodegeneration and neuroprotection.
Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Tryptophan | 2007 |
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kynurenine; Mice; Mutation; Peptides; Quinolinic Acid; Rats; Receptors, Glutamate; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2010 |
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.
Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenic Acid; Mitochondrial Diseases; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolinic Acid; Tryptophan | 2009 |
Kynurenines, neurodegeneration and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Structure; Nerve Degeneration; Plaque, Amyloid; Quinolinic Acid; Tryptophan | 2010 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2012 |
An expanding range of targets for kynurenine metabolites of tryptophan.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Oxidation-Reduction; Quinolinic Acid; Tryptophan | 2013 |
New insights into tryptophan and its metabolites in the regulation of bone metabolism.
Topics: Animals; Bone and Bones; Humans; Kynurenine; Melatonin; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates | 2015 |
Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Quinolinic Acid; Tryptophan | 2017 |
A review of the immunomodulatory role of dietary tryptophan in livestock and poultry.
Topics: Animal Feed; Animals; Dietary Supplements; Humans; Immunity, Innate; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Livestock; Lymphocytes; Melatonin; Poultry; Quinolinic Acid; Serotonin; Swine; Tryptophan | 2017 |
Phytochemical treatments target kynurenine pathway induced oxidative stress.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan | 2018 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progression; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide Synthase; Nitrosative Stress; Oxidative Stress; Quality of Life; Quinolinic Acid; Tryptophan | 2017 |
The role of tryptophan metabolism in postpartum depression.
Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2018 |
Organ Co-Relationship in Tryptophan Metabolism and Factors That Govern the Biosynthesis of Nicotinamide from Tryptophan.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Diet; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Liver; Niacinamide; Nutritional Status; Pentosyltransferases; Quinolinic Acid; Tryptophan; Vitamin B Deficiency; Xanthurenates | 2018 |
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan | 2018 |
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Illness Behavior; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukins; Kynurenine; Models, Neurological; Models, Psychological; Neuroglia; Peripheral Nervous System; Pituitary-Adrenal System; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Social Isolation; Stress, Psychological; Toll-Like Receptor 4; Tryptophan; Vaccines | 2018 |
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis.
Topics: Aged; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2020 |
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinolinic Acid; Tryptophan | 2021 |
Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis.
Topics: Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Prognosis; Quality of Life; Quinolinic Acid; Signal Transduction; Tryptophan | 2021 |
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2021 |
The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives.
Topics: Analgesics; Animals; Biomarkers; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Metabolic Networks and Pathways; Neuralgia; Quinolinic Acid; Tryptophan | 2021 |
Recent advances in clinical trials targeting the kynurenine pathway.
Topics: Humans; Kynurenine; Male; Nervous System Diseases; Quinolinic Acid; Tryptophan | 2022 |
A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.
Topics: Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2022 |
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases.
Topics: Cytokines; Humans; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid; Tryptophan | 2022 |
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information.
Topics: 3-Hydroxyanthranilic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Levodopa; Parkinson Disease; Quinolinic Acid; Tryptophan | 2022 |
Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review.
Topics: Humans; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2022 |
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.
Topics: C-Reactive Protein; Humans; Kynurenine; Quinolinic Acid; Rheumatic Diseases; Tryptophan | 2023 |
9 trial(s) available for quinolinic acid and tryptophan
| Article | Year |
|---|---|
Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations.
Topics: Adult; Brain Diseases; Demography; Electroencephalography; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Tomography, X-Ray Computed; Tryptophan | 1996 |
Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Tryptophan; Viral Load | 2000 |
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; Picolinic Acids; Quinolinic Acid; Retrospective Studies; Tryptophan; Vietnam | 2003 |
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Placebos; Protein Precursors; Quinolinic Acid; Sepsis; Serotonin; Shock, Septic; Treatment Outcome; Tryptophan | 2010 |
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyperparathyroidism, Primary; Inflammation; Kynurenine; Male; Quinolinic Acid; Tryptophan; Ventricular Remodeling | 2017 |
Effect of l-tryptophan and its metabolites on food passage from the crop in chicks.
Topics: Administration, Oral; Alanine; Animals; Asparagine; Chickens; Crop, Avian; Gastrointestinal Motility; Glycine; Kynurenic Acid; Male; Quinolinic Acid; Tryptophan | 2018 |
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha | 2019 |
Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
Topics: Adult; Cross-Over Studies; Endurance Training; Exercise; Humans; Hydrocortisone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Male; Quinolinic Acid; Resistance Training; Transaminases; Tryptophan | 2020 |
Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
Topics: Child; Crohn Disease; Diet; Humans; Kynurenine; Melatonin; Prospective Studies; Quinolinic Acid; Remission Induction; Serotonin; Tryptophan | 2023 |
224 other study(ies) available for quinolinic acid and tryptophan
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Quinolinate in brain and cerebrospinal fluid in rat models of congenital hyperammonemia.
Topics: Acetates; Ammonia; Animals; Brain; Disease Models, Animal; Hydroxyindoleacetic Acid; Male; Metabolism, Inborn Errors; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan; Urease | 1992 |
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1992 |
Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain.
Topics: Animals; Brain; Enzyme Induction; Immunohistochemistry; Interferon-gamma; Macaca; Poliomyelitis; Poliovirus; Quinolinic Acid; Quinolinic Acids; Tryptophan; Tryptophan Oxygenase | 1992 |
Immune activation and neuronal injury in AIDS.
Topics: Acquired Immunodeficiency Syndrome; HIV-1; Humans; Interferon-gamma; Nervous System Diseases; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Serotonin; Tryptophan | 1992 |
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
Topics: Adrenal Cortex Hormones; Adult; Aged; Eosinophilia-Myalgia Syndrome; Female; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Quinolinic Acid; Scleroderma, Systemic; Tryptophan | 1992 |
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1992 |
Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome.
Topics: Arthritis, Rheumatoid; Biopterins; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsaturated; Humans; Kynurenine; Neopterin; Plant Oils; Quinolinic Acid; Quinolinic Acids; Rapeseed Oil; Reference Values; Scleroderma, Systemic; Syndrome; Tryptophan | 1992 |
Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.
Topics: Carbon Isotopes; Cells, Cultured; Humans; Interferon-gamma; Macrophages; Quinolinic Acid; Quinolinic Acids; Recombinant Proteins; Tryptophan | 1992 |
Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.
Topics: Animals; Atrophy; Brain; Cisterna Magna; Convulsants; Injections; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan | 1992 |
The regulation of brain kynurenic acid content: focus on indole-3-pyruvic acid.
Topics: Animals; Biological Clocks; Brain; Brain Chemistry; Enzyme Induction; Humans; Indoles; Interferon Inducers; Kynurenic Acid; Mice; Neurotoxins; Organ Specificity; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tryptophan; Tryptophan Oxygenase | 1991 |
Is quinolinic acid an endogenous excitotoxin in alcohol withdrawal?
Topics: Alcoholism; Animals; Brain; Humans; Kynurenic Acid; Models, Neurological; Quinolinic Acid; Quinolinic Acids; Substance Withdrawal Syndrome; Synaptic Transmission; Tryptophan | 1991 |
Brain and plasma quinolinic acid in profound insulin-induced hypoglycemia.
Topics: Animals; Brain; Catecholamines; Corpus Striatum; Dialysis; Hydroxyindoleacetic Acid; Hypoglycemia; Insulin; Male; Osmolar Concentration; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1990 |
Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dopamine; Female; Gerbillinae; Homovanillic Acid; Hydroxyindoleacetic Acid; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Serotonin; Time Factors; Tryptophan | 1990 |
Increased L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid concentrations in cerebral cortex following systemic endotoxin administration.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Quinolinic Acid; Quinolinic Acids; Serotonin; Stimulation, Chemical; Tryptophan | 1991 |
Effects of profound insulin-induced hypoglycemia on quinolinic acid in hippocampus and plasma.
Topics: Animals; Brain Chemistry; Brain Diseases, Metabolic; Dialysis; Electroencephalography; Extracellular Space; Hippocampus; Hydroxyindoleacetic Acid; Hypoglycemia; Insulin; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serotonin; Tryptophan | 1991 |
The effect of aluminum on rat brain and liver quinolinic acid concentrations.
Topics: Alum Compounds; Animals; Cerebral Cortex; Liver; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase | 1991 |
Stable isotope-labeled tryptophan as a precursor for studying the disposition of quinolinic acid in rabbits.
Topics: Animals; Deuterium; Half-Life; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rabbits; Tissue Distribution; Tryptophan | 1991 |
Indolic and kynurenine pathway metabolites of tryptophan in rat brain: effect of precursor availability on in vivo release.
Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Indoles; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1991 |
Efficiency of exogenous quinolinic acid, a metabolite of tryptophan, as a niacin precursor in rats.
Topics: Animals; Male; Niacin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1991 |
Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.
Topics: Animals; Brain; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Reference Values; Retroviruses, Simian; Simian Acquired Immunodeficiency Syndrome; Tryptophan | 1990 |
The eosinophilia-myalgia syndrome.
Topics: Animals; Eosinophilia; Female; Humans; Middle Aged; Muscular Diseases; Pain; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Syndrome; Tryptophan | 1990 |
Neurotoxicity of tryptophan metabolites.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Kynurenic Acid; Male; NADP; Nervous System Diseases; Neurons; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1990 |
AIDS dementia may be linked to metabolite of tryptophan.
Topics: AIDS Dementia Complex; Animals; Humans; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Tryptophan | 1990 |
Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Acetylcholine; Animals; Brain; Cerebral Cortex; In Vitro Techniques; Kynurenic Acid; Male; Neurotoxins; Parietal Lobe; Picolinic Acids; Potassium; Quinolines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1990 |
Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral status.
Topics: Animals; Catecholamines; Kynurenic Acid; Macaca; Macaca mulatta; Pyridines; Quinolinic Acid; Quinolinic Acids; Retroviridae Infections; Tryptophan | 1990 |
Peripheral neuropathy associated with eosinophilia-myalgia syndrome.
Topics: Adult; Biopsy; Demyelinating Diseases; Drug Contamination; Eosinophilia; Female; Humans; Middle Aged; Muscles; Muscular Diseases; Nerve Degeneration; Peripheral Nervous System Diseases; Quinolinic Acid; Quinolinic Acids; Sural Nerve; Syndrome; Tryptophan | 1990 |
Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy.
Topics: Acetates; Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Portacaval Shunt, Surgical; Probenecid; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1986 |
Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure.
Topics: Aged; Cerebral Cortex; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pyridines; Quinolinic Acid; Quinolinic Acids; Serotonin; Tryptophan | 1986 |
Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex.
Topics: Animals; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Kynurenine; Mice; Mice, Inbred C57BL; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Time Factors; Tryptophan | 1989 |
Quinolinic acid concentrations in striatal extracellular fluid reach potentially neurotoxic levels following systemic L-tryptophan loading.
Topics: Animals; Corpus Striatum; Extracellular Space; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Time Factors; Tryptophan | 1989 |
Neuroactive metabolites of L-tryptophan, serotonin and quinolinic acid, in striatal extracellular fluid. Effect of tryptophan loading.
Topics: Animals; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Extracellular Space; Kinetics; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1989 |
Tryptophan metabolism by the isolated rat liver cells--effects of leucine and its metabolites.
Topics: Acetoacetates; Animals; In Vitro Techniques; Keto Acids; Leucine; Liver; NAD; Pentosyltransferases; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1989 |
Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Tryptophan | 1989 |
Production of extracellular quinolinic acid in the striatum studied by microdialysis in unanesthetized rats.
Topics: 3-Hydroxyanthranilic Acid; Animals; Corpus Striatum; Extracellular Space; Ibotenic Acid; Kynurenic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1989 |
Effect of dietary orotic acid on the levels of liver and blood NAD in rats.
Topics: Animals; Body Weight; Creatinine; Diet; DNA; Fats; Liver; Male; NAD; Niacin; Organ Size; Orotic Acid; Proteins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Time Factors; Tryptophan | 1985 |
Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate.
Topics: 3-Hydroxyanthranilic Acid; Catalase; Hydrogen-Ion Concentration; Kinetics; ortho-Aminobenzoates; Oxazines; Oxidation-Reduction; Oxygen Consumption; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Superoxide Dismutase; Tryptophan | 1987 |
Systemic lipopolysaccharide and pokeweed mitogen increase quinolinic acid content of mouse cerebral cortex.
Topics: Animals; Cerebral Cortex; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Tryptophan | 1988 |
The physiopathological role of quinolinic acid in the mammalian central nervous system.
Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Male; Portacaval Shunt, Surgical; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1988 |
Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations.
Topics: Animals; Brain; Brain Chemistry; Gas Chromatography-Mass Spectrometry; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Standards; Reference Values; Tryptophan | 1988 |
Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro.
Topics: Animals; Kinetics; Kynurenic Acid; Liver; Male; Oxidoreductases Acting on CH-NH Group Donors; Phosphotransferases; Picolinic Acids; Pyridoxal Kinase; Pyridoxaminephosphate Oxidase; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptamines; Tryptophan; Xanthurenates | 1985 |
Fasciola hepatica: inhibition of phosphoenolpyruvate carboxykinase, and end-product formation by quinolinic acid and 3-mercaptopicolinic acid.
Topics: Acetates; Animals; Dose-Response Relationship, Drug; Fasciola hepatica; Lactates; Lactic Acid; Phosphoenolpyruvate Carboxykinase (GTP); Picolinic Acids; Propionates; Pyridines; Pyruvate Kinase; Quinolinic Acid; Quinolinic Acids; Succinates; Succinic Acid; Tryptophan | 1983 |
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Thinness; Tryptophan | 1995 |
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan | 1995 |
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates | 1995 |
6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Immune System; Kynurenine; Lung; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1994 |
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan).
Topics: Animals; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Fascia; Female; Mice; Mice, Inbred C57BL; Muscles; Quinolinic Acid; Tryptophan | 1994 |
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Carbon Isotopes; Dioxygenases; Female; Gerbillinae; Hydrolases; Ischemic Attack, Transient; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Lyases; Lymphocyte Activation; Mitochondria; Mixed Function Oxygenases; Organ Specificity; Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Synaptosomes; Transaminases; Tryptophan; Tryptophan Oxygenase | 1993 |
Huntington's disease and low tryptophan diet.
Topics: Brain; Female; Humans; Huntington Disease; Models, Biological; Nerve Degeneration; Quinolinic Acid; Tryptophan | 1993 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1993 |
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Epilepsy; Escherichia coli; Lipopolysaccharides; Methionine; Mice; Mice, Inbred Strains; Mice, Neurologic Mutants; Quinolinic Acid; Species Specificity; Threonine; Tryptophan | 1993 |
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Female; Gerbillinae; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Macrophages; Pokeweed Mitogens; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase | 1993 |
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Carbolines; Cell Line; Harmine; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Macrophages; Quinolinic Acid; Rats; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice.
Topics: Animals; Brain; Enzyme Inhibitors; Indoles; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1996 |
Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cells, Cultured; HIV-1; Humans; Neurotoxins; Phagocytes; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors; Tryptophan | 1996 |
Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.
Topics: Cells, Cultured; DNA, Viral; Human T-lymphotropic virus 1; Humans; Interferon-gamma; Kynurenine; Macrophages; Monocytes; Neuroimmunomodulation; Polymerase Chain Reaction; Proviruses; Quinolinic Acid; Tryptophan | 1996 |
Evidence of excitotoxicity in the brain of the ornithine carbamoyltransferase deficient sparse fur mouse.
Topics: Ammonia; Animals; Brain Damage, Chronic; Disease Models, Animal; Glutamine; Hair; Metabolism, Inborn Errors; Mice; Mice, Inbred Strains; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Quinolinic Acid; Tryptophan | 1995 |
Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan.
Topics: Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Male; Microdialysis; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 1996 |
Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy.
Topics: Anti-HIV Agents; Biopterins; Chromatography, High Pressure Liquid; HIV Infections; HIV Seropositivity; Humans; Kynurenine; Neopterin; Quinolinic Acid; Radioimmunoassay; Time Factors; Tryptophan; Zidovudine | 1996 |
Regulation of quinolinic acid in the normal rat brain by kynurenine pathway precursors.
Topics: 3-Hydroxyanthranilic Acid; Analysis of Variance; Animals; Cerebral Ventricles; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan | 1996 |
Is quinolinic acid involved in the pathogenesis of hepatic encephalopathy?
Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Extracellular Space; Hepatic Encephalopathy; Portacaval Shunt, Surgical; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Reference Values; Time Factors; Tryptophan | 1996 |
Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys.
Topics: Animals; Antibody Specificity; Cell Size; Cells, Cultured; Immunohistochemistry; Kynurenine; Macaca mulatta; Macrophages; Monocytes; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan | 1996 |
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
Topics: Astrocytes; Brain; Carbon Isotopes; Cells, Cultured; Fetus; Humans; Interferon-gamma; Isotope Labeling; Kynurenine; Macrophages; Microglia; Neurons; Neurotoxins; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1996 |
Capillary zone electrophoresis separation of tryptophan and its metabolites, including quinolinic acid.
Topics: Buffers; Edetic Acid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Quinolinic Acid; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tryptophan | 1997 |
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Aggregation; Cells, Cultured; Coloring Agents; Fetus; HIV-1; Humans; Immunohistochemistry; Kynurenine; L-Lactate Dehydrogenase; Macrophages; Microscopy, Electron; Quinolinic Acid; Trypan Blue; Tryptophan | 1997 |
Stimulation of NGF production by tryptophan and its metabolites in cultured mouse astroglial cells.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Kynurenine; Mice; Mice, Inbred C3H; Nerve Growth Factors; Quinolinic Acid; Serotonin; Tryptophan | 1997 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1998 |
Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid.
Topics: Animals; Brain; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice; Mixed Function Oxygenases; Prosencephalon; Quinolinic Acid; Spinal Cord; Tryptophan; Tryptophan Oxygenase | 1998 |
Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells.
Topics: Animals; Astrocytes; Cells, Cultured; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Quinolinic Acid; RNA, Messenger; Serotonin; Tryptophan | 1998 |
Differential effects of kynurenine and tryptophan treatment on quinolinate immunoreactivity in rat lymphoid and non-lymphoid organs.
Topics: Animals; Immunohistochemistry; Injections, Intraperitoneal; Kynurenine; Lymphoid Tissue; Male; NAD; Organ Specificity; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 1998 |
The analgesic effects of tryptophan and its metabolites in the rat.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates | 1998 |
Effects of electromagnetic fields on the levels of biogenic amine metabolites, quinolinic acid, and beta-endorphin in the cerebrospinal fluid of dairy cows.
Topics: Animals; beta-Endorphin; Biogenic Amines; Cattle; Dairying; Electromagnetic Fields; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Quinolinic Acid; Tryptophan | 1998 |
Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?
Topics: Animals; Benzamides; Cell Line; Dexamethasone; Enzyme Inhibitors; Interferon-gamma; Macrophage Activation; Macrophages; Mice; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tryptophan Oxygenase | 1999 |
3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Brain; Dioxygenases; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Kynurenic Acid; Male; Oxygenases; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan | 1999 |
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?
Topics: Antimalarials; Biopterins; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Endothelium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Infant; Kenya; Malaria, Cerebral; Microglia; Neopterin; Nitrates; Nitrites; Quinolinic Acid; Tryptophan | 2000 |
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Topics: Adult; Albuminuria; Animals; Carboxy-Lyases; Enzyme Inhibitors; Female; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Middle Aged; Mixed Function Oxygenases; Pentosyltransferases; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Tryptophan Oxygenase | 2000 |
Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices.
Topics: Aerobiosis; Animals; Brain; In Vitro Techniques; Kynurenine; Liver; Male; NAD; Organ Specificity; Oxygen; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2000 |
Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.
Topics: Adult; Biogenic Monoamines; Brain Diseases; Brain Neoplasms; Digoxin; Epilepsy, Generalized; Erythrocytes; Fatty Acids, Nonesterified; Female; Glioma; Glycine Agents; Humans; Hydroxymethylglutaryl CoA Reductases; Kynurenic Acid; Magnesium; Male; Microvascular Angina; Middle Aged; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Parkinson Disease; Quinolinic Acid; Schizophrenia; Serum Albumin; Sodium-Potassium-Exchanging ATPase; Strychnine; Tryptophan; Tyrosine; Ubiquinone | 2000 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2001 |
Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats.
Topics: Animals; Antitubercular Agents; Diet; Eating; Liver; Male; NAD; NADP; Niacin; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tryptophan; Weight Gain | 2001 |
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas.
Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retardation; Infusions, Intravenous; Kynurenic Acid; Placenta; Placental Insufficiency; Pregnancy; Pregnancy, Animal; Probability; Quinolinic Acid; Reference Values; Sensitivity and Specificity; Sheep; Tryptophan | 2001 |
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Topics: Cell Death; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Hydrolases; Interferon-gamma; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Macrophages; Mixed Function Oxygenases; Monocytes; Neurons; Neurotoxins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Tryptophan; Tumor Necrosis Factor-alpha | 2001 |
Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats.
Topics: 3-Hydroxyanthranilic Acid; Adenine; Animals; Kidney; Kynurenic Acid; Liver; Male; NAD; Niacin; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Xanthurenates | 2001 |
IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fibroblast Growth Factor 2; Glutarates; Growth Substances; Hydrogen-Ion Concentration; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I; Male; Neostriatum; Nerve Degeneration; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2001 |
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan | 2001 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates | 2002 |
Endogenous neurotoxine-quinolinic acid is increased in renal allograft recipients.
Topics: Adult; Aged; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Neurotoxins; Quinolinic Acid; Reference Values; Renal Dialysis; Transplantation, Homologous; Tryptophan | 2002 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates | 2001 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflammation; Injections, Subcutaneous; Kidney; Kynurenine; Lipopolysaccharides; Liver; Lung; Mass Spectrometry; Models, Biological; Protein Binding; Quinolinic Acid; Serum Albumin; Tissue Distribution; Tritium; Tryptophan | 2002 |
Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Carboxy-Lyases; COS Cells; DNA, Complementary; DNA, Recombinant; Humans; Kidney; Molecular Sequence Data; Niacin; Quinolinic Acid; Sequence Homology, Amino Acid; Swine; Tryptophan | 2002 |
Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.
Topics: Animals; Diet; Fats; Fatty Liver; Feeding Behavior; Liver; Male; NAD; NADP; Niacin; Organ Size; Orotic Acid; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Vitamin B Deficiency; Weight Gain | 2002 |
Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts.
Topics: Alanine; Animals; Dietary Proteins; Dog Diseases; Dogs; Female; Glutamine; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Portal System; Quinolinic Acid; Serine; Tryptophan | 2002 |
T cell apoptosis by tryptophan catabolism.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Autoimmune Diseases; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; fas Receptor; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Mitochondria; Quinolinic Acid; Self Tolerance; T-Lymphocytes; Th1 Cells; Thymus Gland; Tryptophan | 2002 |
Identification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate.
Topics: Animals; Body Weight; Carboxy-Lyases; Diethylhexyl Phthalate; Feeding Behavior; Hexanols; Liver; Niacin; Quinolinic Acid; Rats; Tryptophan | 2002 |
Hypothalamic digoxin, hemispheric chemical dominance, and Alzheimer's disease.
Topics: Aged; Albumins; alpha-Tocopherol; Alzheimer Disease; Ceruloplasmin; Digoxin; Dolichols; Dominance, Cerebral; Erythrocyte Membrane; Female; Free Radicals; Functional Laterality; Glycosaminoglycans; Humans; Hydroxymethylglutaryl CoA Reductases; Hypothalamus; Iron; Lysosomes; Magnesium; Male; Matched-Pair Analysis; Middle Aged; Phosphoprotein Phosphatases; Quinolinic Acid; Serotonin; Sodium-Potassium-Exchanging ATPase; Tryptophan | 2003 |
Tryptophan-niacin relationship in Xanthomonas pruni.
Topics: Niacin; Nicotinic Acids; Quinolinic Acid; Tryptophan; Xanthomonas | 1963 |
Neurotoxic and neurobehavioral effects of kynurenines in adult insects.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Survival; Cells, Cultured; Diptera; Dose-Response Relationship, Drug; Grasshoppers; Insecta; Kynurenine; Lethal Dose 50; Nervous System; Neurons; Neurotoxicity Syndromes; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2003 |
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
Topics: Arylformamidase; Bacteria; Chromosomes, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Complementation Test; Hydrolases; Kinetics; Molecular Sequence Data; NAD; Oxidoreductases; Quinolinic Acid; Tryptophan | 2003 |
Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery.
Topics: Adolescent; Adult; Age Factors; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Male; Neocortex; Quinolinic Acid; Reoperation; Tomography, Emission-Computed; Treatment Failure; Tryptophan | 2004 |
Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
Topics: Animals; Dose-Response Relationship, Drug; Eating; Liver; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Predictive Value of Tests; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Weaning; Weight Gain | 2004 |
The conversion of deutero-N15 tryptophan to quinolinic acid by the rat.
Topics: Animals; Quinolines; Quinolinic Acid; Rats; Tryptophan | 1952 |
Effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in mice.
Topics: Analysis of Variance; Animals; Body Weights and Measures; Diet; Diethylhexyl Phthalate; Mice; Niacin; Quinolinic Acid; Tryptophan | 2004 |
Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carboxy-Lyases; Cloning, Molecular; COS Cells; DNA, Complementary; Gene Expression; Humans; Models, Biological; Molecular Sequence Data; Niacin; Quinolinic Acid; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection; Tryptophan | 2003 |
Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway.
Topics: Animals; Body Weight; Carboxy-Lyases; Chromatography, High Pressure Liquid; Diet; Diethylhexyl Phthalate; Eating; Enzyme Inhibitors; Esters; Humans; Liver; Mice; Mice, Inbred ICR; Organ Size; Phthalic Acids; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan | 2004 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neurons; Phenotype; Pregnancy; Quinolinic Acid; Rats; Transaminases; Tryptophan | 2004 |
Quinolinic acid metabolism; urinary excretion by the rat following tryptophan and 3-hydroxyanthranilic acid administration.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Fluids; Quinolines; Quinolinic Acid; Rats; Tryptophan; Urine | 1949 |
Quinolinic acid metabolism, urinary excretion by man and other mammals as affected by the ingestion of tryptophan.
Topics: Animals; Eating; Humans; Male; Mammals; Quinolines; Quinolinic Acid; Tryptophan | 1949 |
Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression.
Topics: Animals; Body Weight; Carboxy-Lyases; Dietary Fats; Eating; Energy Intake; Gene Expression; Linoleic Acid; Liver; Male; Organ Size; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stearic Acids; Time Factors; Tryptophan | 2004 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Quinolinic Acid; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured; Up-Regulation | 2005 |
Is the L-tryptophan metabolite quinolinic acid responsible for eosinophilic fasciitis?
Topics: Eosinophilia; Fasciitis; Humans; Immunohistochemistry; In Vitro Techniques; Quinolinic Acid; Tryptophan | 2006 |
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
Topics: Binding Sites; Crystallography, X-Ray; Glycine; Heme; Indoleamine-Pyrrole 2,3,-Dioxygenase; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Folding; Quinolinic Acid; Ralstonia; Structure-Activity Relationship; Substrate Specificity; Tryptophan; Tryptophan Oxygenase | 2007 |
Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism.
Topics: Amino Acid Sequence; Brain; Carboxy-Lyases; Electrophoresis, Polyacrylamide Gel; Gene Expression Profiling; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Isoenzymes; Kidney; Kinetics; Liver; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Structure, Secondary; Quinolinic Acid; Recombinant Proteins; Sequence Alignment; Tryptophan | 2007 |
Dietary protein level and dietary interaction affect quinolinic acid concentration in rats.
Topics: Analysis of Variance; Animals; Body Weight; Carboxy-Lyases; Caseins; Diet; Dietary Proteins; Dose-Response Relationship, Drug; Fatty Acids; Kidney; Linoleic Acid; Liver; Male; Organ Size; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stearic Acids; Tryptophan | 2007 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2007 |
Quinolinic acid excretion by the rat receiving tryptophan.
Topics: Animals; Quinolinic Acid; Quinolinic Acids; Rats; Tryptophan; Urine | 1949 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Disease Models, Animal; Electroencephalography; Encephalitis, Viral; Hippocampus; Kynurenine; Measles virus; Mice; Mice, Inbred BALB C; Microglia; Monitoring, Physiologic; Nerve Degeneration; Neuroglia; Pyramidal Cells; Quinolinic Acid; Seizures; Tryptophan | 2008 |
Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans.
Topics: 3-Hydroxyanthranilic Acid; Adult; Chromatography, High Pressure Liquid; Feedback, Physiological; Female; Humans; Kynurenic Acid; Niacinamide; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2007 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia | 2009 |
Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Hepatocytes; Kynurenine; Male; Niacinamide; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tritium; Tryptophan; Water | 2009 |
[Effects of excess nicotinic acid on growth and the urinary excretion of B-group vitamins and the metabolism of tryptophan in weaning rats].
Topics: Animals; Eating; Growth; Male; Niacin; Quinolinic Acid; Rats; Rats, Wistar; Reference Values; Serotonin; Tryptophan; Vitamin B Complex; Weight Gain | 2009 |
[Tryptophan and its metabolites in renal allograft recipients].
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Quinolinic Acid; Reference Values; Tryptophan; Urea | 2009 |
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
Topics: Adult; Antifibrinolytic Agents; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Fibrinolysin; Hemostasis; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Peptide Fragments; Peritoneal Dialysis, Continuous Ambulatory; Plasminogen Activator Inhibitor 1; Poland; Prevalence; Prothrombin; Quinolinic Acid; Receptors, Urokinase Plasminogen Activator; Thromboplastin; Tryptophan; Urokinase-Type Plasminogen Activator | 2010 |
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis C; Humans; Interferon-alpha; Kynurenine; Longitudinal Studies; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type II; Ribavirin; Statistics as Topic; Tryptophan | 2010 |
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Quinolinic Acid; Signal Transduction; Spinal Cord; Tryptophan | 2010 |
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan | 2009 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2010 |
Human myeloid dendritic cells are refractory to tryptophan metabolites.
Topics: Antibodies; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Dendritic Cells; Flow Cytometry; Humans; Immunity, Cellular; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Macrophages; Membrane Glycoproteins; Monocytes; Quinolinic Acid; Receptors, Cell Surface; Receptors, Immunologic; T-Lymphocytes, Regulatory; Tryptophan | 2011 |
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
Topics: Adult; Aged; Depressive Disorder, Major; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Microglia; Middle Aged; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptophan | 2011 |
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Liver; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Signal Transduction; Transaminases; Tryptophan; Tryptophan Oxygenase | 2011 |
Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase.
Topics: Adolescent; Adult; Aged; Chromatography, Liquid; Gene Expression Regulation, Enzymologic; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Intestines; Kynurenine; Mass Spectrometry; Middle Aged; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Time Factors; Transplantation, Homologous; Tryptophan; Young Adult | 2011 |
Essential role of excessive tryptophan and its neurometabolites in fatigue.
Topics: Acetylglucosaminidase; Amino Acids, Branched-Chain; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Exercise Test; Exploratory Behavior; Fatigue; Female; Fluoxetine; Hydroxyindoleacetic Acid; Kynurenic Acid; Locomotion; Maze Learning; Microdialysis; Quinolinic Acid; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereotyped Behavior; Synaptosomes; Time Factors; Tryptophan | 2012 |
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.
Topics: Animals; Antipsychotic Agents; Clozapine; Kynurenine; Male; ortho-Aminobenzoates; Oxidative Stress; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Social Isolation; Tryptophan | 2012 |
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2012 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan | 2013 |
Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.
Topics: 3-Hydroxyanthranilic Acid; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Food, Formulated; Liver; Male; Niacinamide; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Valproic Acid | 2013 |
The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Microglia; NAD; Oxidative Stress; Pentosyltransferases; Quinolinic Acid; Temozolomide; Tryptophan; Tryptophan Oxygenase | 2013 |
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2013 |
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2013 |
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokines; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Nitric Oxide; ortho-Aminobenzoates; Peroxidase; Picornaviridae Infections; Prospective Studies; Quinolinic Acid; Rhinovirus; Tryptophan; Young Adult | 2013 |
The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.
Topics: Adult; Aged; Amino Acid Sequence; Brain; Carboxy-Lyases; DNA Mutational Analysis; Electroencephalography; Epilepsies, Myoclonic; Exome; Female; High-Throughput Nucleotide Sequencing; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Sequence Data; Mutation; Neuropsychological Tests; Pedigree; Quinolinic Acid; Sequence Alignment; Tryptophan; Young Adult | 2013 |
Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
Topics: Animals; Body Weight; Eating; Enzymes; Male; Mice; NAD; Niacinamide; Pyridones; Quinolinic Acid; Tryptophan | 2013 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan | 2014 |
Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry.
Topics: Adult; Animals; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kynurenine; Linear Models; Male; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reproducibility of Results; Serotonin; Tryptophan; Young Adult | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan | 2014 |
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan | 2015 |
Involvement of the kynurenine pathway in human glioma pathophysiology.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Biosynthetic Pathways; Brain Neoplasms; Carboxy-Lyases; CD11b Antigen; Cells, Cultured; Chromatography, High Pressure Liquid; Disaccharides; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Glucuronates; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2014 |
Large amounts of picolinic acid are lethal but small amounts increase the conversion of tryptophan-nicotinamide in rats.
Topics: Animals; Body Weight; Carboxy-Lyases; Dose-Response Relationship, Drug; Iron Chelating Agents; Kynurenic Acid; Liver; Male; Niacinamide; ortho-Aminobenzoates; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Xanthurenates | 2014 |
Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers.
Topics: Adolescent; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Interview, Psychological; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Signal Transduction; Treatment Outcome; Tryptophan; Young Adult | 2015 |
Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
Topics: Animals; Anti-Retroviral Agents; Brain; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Kynurenine; Macaca; Polymerase Chain Reaction; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Tryptophan | 2015 |
Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.
Topics: Amino Acid Transport Systems; Bleomycin; DNA Damage; DNA Repair; Galactose; Mechanistic Target of Rapamycin Complex 1; Membrane Proteins; Multiprotein Complexes; NAD; Quinolinic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Telomere; TOR Serine-Threonine Kinases; Tryptophan | 2015 |
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.
Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Kynurenic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurotoxicity Syndromes; Oxidative Stress; Quinolinic Acid; Receptors, Aryl Hydrocarbon; Tryptophan | 2015 |
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Case-Control Studies; Female; Glasgow Outcome Scale; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neurotoxins; Prognosis; Quinolinic Acid; RNA, Messenger; Signal Transduction; Tryptophan; Young Adult | 2015 |
Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats.
Topics: Animals; Antidepressive Agents; Chromatography, Liquid; Depression; Dose-Response Relationship, Drug; Electrochemistry; Food Preferences; Hippocampus; Illness Behavior; Interferon-alpha; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Saccharin; Statistics, Nonparametric; Sweetening Agents; Swimming; Tryptophan | 2015 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Cross-Sectional Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gas Chromatography-Mass Spectrometry; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-6; Kynurenine; Male; Middle Aged; Neopterin; Niacinamide; Pentosyltransferases; Poverty; Quinolinic Acid; South Africa; Tryptophan | 2015 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan | 2016 |
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay.
Topics: Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Growth Inhibitors; Humans; Interferon-gamma; Interleukin-6; Kynurenine; Melatonin; Milk, Human; Neuroglia; ortho-Aminobenzoates; Oxygen Radical Absorbance Capacity; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult | 2016 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2015 |
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates | 2015 |
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan | 2016 |
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan | 2016 |
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis.
Topics: Adult; Bariatric Surgery; C-Reactive Protein; Diabetes Mellitus; Female; Glucose; Homeostasis; Humans; Kynurenine; Metabolome; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates | 2016 |
LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Humans; Kynurenine; Mice, Inbred C57BL; Neopterin; ortho-Aminobenzoates; Quinolinic Acid; Signal Transduction; Tandem Mass Spectrometry; Tryptophan | 2016 |
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
Topics: Flagellin; Gene Expression Regulation; Humans; Hydrolysis; Imidazoles; Kynurenic Acid; Kynurenine; Lipopeptides; Lipopolysaccharides; Listeria monocytogenes; Monocytes; Poly I-C; Primary Cell Culture; Protein Isoforms; Quinolinic Acid; Signal Transduction; Toll-Like Receptors; Tryptophan | 2016 |
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity.
Topics: Bipolar Disorder; Female; Humans; Interleukin-6; Interleukin-8; Kynurenic Acid; Male; Middle Aged; Personality; Psychotic Disorders; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Tumor Necrosis Factor-alpha; Twins | 2017 |
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Topics: Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Coenzyme A; Dysbiosis; Female; Humans; Hydrophobic and Hydrophilic Interactions; Indoleacetic Acids; Italy; Kynurenic Acid; Male; Melatonin; Metabolomics; Pantothenic Acid; Purines; Pyrimidines; Quinolinic Acid; Riboflavin; Tryptophan; Vitamin B 6; Xanthurenates | 2016 |
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
Topics: Animals; Ataxin-3; Calcium; Calpain; Cerebellum; Disease Models, Animal; HEK293 Cells; Humans; Machado-Joseph Disease; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neuroprotective Agents; Phthalic Anhydrides; Quinolinic Acid; Ryanodine Receptor Calcium Release Channel; Tryptophan; Tryptophan Oxygenase | 2017 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2017 |
Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.
Topics: Adult; Biomarkers; Female; Humans; Immunity, Cellular; Immunoglobulin M; Kynurenic Acid; Male; Metabolism; Middle Aged; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Signal Transduction; Tryptophan; Xanthurenates | 2018 |
Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain.
Topics: Animals; Brain; Female; Indoles; Inflammation; Placenta; Pregnancy; Quinolinic Acid; Rabbits; Serotonin; Tryptophan | 2017 |
Uridine monophosphate synthetase enables eukaryotic
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Multienzyme Complexes; Mutation; NAD; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Quinolinic Acid; Tryptophan | 2017 |
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative Stress; Quinolinic Acid; Tryptophan | 2017 |
Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Transport Systems, Neutral; Biomarkers; Biotransformation; C-Reactive Protein; Case-Control Studies; Colitis, Ulcerative; Colon; Crohn Disease; Feces; Female; Gastrointestinal Microbiome; Germany; Humans; Inflammation Mediators; Interleukin-22; Interleukins; Male; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase; Young Adult | 2017 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Female; Humans; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Signal Transduction; Statistics, Nonparametric; Tryptophan; Xanthurenates | 2017 |
Effects of high ambient temperature on plasma metabolomic profiles in chicks.
Topics: Amino Acids, Sulfur; Animals; Chickens; Cystathionine; Cysteine; Cystine; Environmental Exposure; Gas Chromatography-Mass Spectrometry; Homocysteine; Hot Temperature; Kynurenine; Molecular Weight; Niacinamide; Oxidative Stress; Quinolinic Acid; Taurine; Tryptophan | 2018 |
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Locomotion; Male; Neural Cell Adhesion Molecules; Quinolinic Acid; Rats, Sprague-Dawley; Signal Transduction; Tryptophan | 2018 |
A validated liquid chromatography-high resolution-tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Kynurenic Acid; Kynurenine; Limit of Detection; Metabolome; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2017 |
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan | 2019 |
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.
Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Cognition Disorders; Executive Function; Female; Humans; Immunoglobulin A; Immunoglobulin M; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Neuropsychological Tests; Picolinic Acids; Psychiatric Status Rating Scales; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Xanthurenates; Young Adult | 2018 |
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Child; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2018 |
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan | 2018 |
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Lung Neoplasms; Male; Multivariate Analysis; Programmed Cell Death 1 Receptor; Quinolinic Acid; Tryptophan | 2018 |
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan | 2019 |
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age.
Topics: Aged; Aged, 80 and over; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Quinolinic Acid; Tryptophan | 2018 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult | 2019 |
Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenine; Male; Neurotransmitter Agents; Plasma; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tandem Mass Spectrometry; Toxoplasmosis; Tryptophan | 2019 |
Effect of quinolinic acid - A uremic toxin from tryptophan metabolism - On hemostatic profile in rat and mouse thrombosis models.
Topics: Animals; Fibrinolysis; Hemostasis; Male; Mice; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thrombosis; Tryptophan | 2019 |
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.
Topics: Adult; Aged; Bipolar Disorder; Chemokine CCL2; Cohort Studies; Female; Humans; Kynurenic Acid; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Sweden; Tryptophan | 2020 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio | 2020 |
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates | 2020 |
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan | 2020 |
A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis.
Topics: Adult; Biomarkers; Calibration; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Picolinic Acids; Quinolinic Acid; Reference Standards; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2020 |
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oximes; Peptide Fragments; Quinolinic Acid; Sulfonamides; Tryptophan | 2020 |
Formation of amino acid derivatives in white and red wines during fermentation: Effects of non-Saccharomyces yeasts and Oenococcus oeni.
Topics: Amino Acids; Fermentation; Food Microbiology; Oenococcus; Picolinic Acids; Quinolinic Acid; Saccharomyces cerevisiae; Saccharomycetales; Torulaspora; Tryptophan; Wine | 2021 |
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Psychometrics; Quinolinic Acid; Tryptophan | 2021 |
Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.
Topics: Humans; Kynurenic Acid; Kynurenine; Memory, Short-Term; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.
Topics: Adult; Case-Control Studies; Cognition; Cognitive Dysfunction; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Tryptophan; Young Adult | 2021 |
Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes.
Topics: Adolescent; Child; Chromatography, Liquid; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Glucose; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2021 |
Does the type of exercise affect tryptophan catabolism in horses?
Topics: Animals; Chromatography, High Pressure Liquid; Horses; Kynurenic Acid; Quinolinic Acid; Tryptophan | 2021 |
δ
Topics: Biomarkers; Depressive Disorder, Major; Heart Rate; Humans; Kynurenine; Quinolinic Acid; Reproducibility of Results; Sensitivity and Specificity; Stress, Physiological; Tryptophan | 2021 |
Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus.
Topics: Cognitive Dysfunction; Cross-Sectional Studies; Humans; Kynurenine; Lupus Erythematosus, Systemic; Neuropsychological Tests; Quinolinic Acid; Tryptophan | 2021 |
Cell stress response impairs de novo NAD+ biosynthesis in the kidney.
Topics: Acute Kidney Injury; Animals; Cell Line; Endoplasmic Reticulum Stress; Kidney; Male; Mice; Mice, Inbred C57BL; NAD; Pentosyltransferases; Quinolinic Acid; Tryptophan | 2022 |
Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Apoptosis; Autopsy; Brain; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung; Middle Aged; Myocardium; Prospective Studies; Quinolinic Acid; Severity of Illness Index; Tryptophan | 2022 |
Alterations in Kynurenine and NAD
Topics: Colitis; Humans; Inflammatory Bowel Diseases; Infliximab; Kynurenine; Metabolic Networks and Pathways; Nicotinamide N-Methyltransferase; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, Nicotinic; Tryptophan | 2021 |
Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
Topics: Adult; Aged; COVID-19; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Picolinic Acids; Prognosis; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2022 |
Quinolinic Acid, a Tryptophan Metabolite of the Skin Microbiota, Negatively Regulates NLRP3 Inflammasome through AhR in Psoriasis.
Topics: Animals; Humans; Inflammasomes; Mice; Microbiota; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Quinolinic Acid; Receptors, Aryl Hydrocarbon; Skin; Tryptophan | 2022 |
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
Topics: Behcet Syndrome; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
Topics: Cross-Sectional Studies; Female; Humans; Kynurenic Acid; Kynurenine; Polycystic Ovary Syndrome; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Neopterin; Quinolinic Acid; Substance Withdrawal Syndrome; Tryptophan | 2022 |
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Lymnaea; Quinolinic Acid; Tryptophan | 2022 |
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan | 2022 |
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE.
Topics: Cognitive Dysfunction; Humans; Interferons; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Quinolinic Acid; Tryptophan | 2022 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic Acid; Kynurenine; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis.
Topics: Animals; Biological Products; Brain Neoplasms; Glioblastoma; Immune Tolerance; Macrophages; Mice; Neurodegenerative Diseases; PPAR gamma; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Tryptophan; Tumor Microenvironment | 2023 |
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocytosis; Male; Neopterin; Nervous System Diseases; Neuroinflammatory Diseases; Quinolinic Acid; Tryptophan | 2023 |
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.
Topics: Adolescent; Animals; Coleoptera; Depression; Gastrointestinal Microbiome; Humans; Kynurenine; Metabolomics; Mice; Microbiota; Quinolinic Acid; Serotonin; Sertraline; Tryptophan | 2023 |
Relationship of tryptophan metabolites with the type and severity of multiple sclerosis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Mammals; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2023 |
Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
Topics: Acute Kidney Injury; Animals; Hepatocyte Nuclear Factors; Kidney; Mice; NAD; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Quinolinic Acid; Tryptophan | 2023 |
The possible role of quinolinic acid as a predictive marker in patients with SARS-CoV-2.
Topics: C-Reactive Protein; COVID-19; Humans; Kynurenine; Procalcitonin; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2023 |