quinolinic acid and tryptophan

quinolinic acid has been researched along with tryptophan in 271 studies

Research

Studies (271)

TimeframeStudies, this research(%)All Research%
pre-199020 (7.38)18.7374
1990's61 (22.51)18.2507
2000's54 (19.93)29.6817
2010's84 (31.00)24.3611
2020's52 (19.19)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Anegawa, NJ; Batshaw, ML; Djali, S; Gorry, E; Heyes, MP; Mellits, ED; Robinson, MB1
Pewnim, T; Seifert, J1
Heyes, MP; Jacobowitz, D; Markey, SP; Saito, K; Takikawa, O; Vickers, JH1
Fuchs, D; Reibnegger, G; Wachter, H; Weiss, G; Werner-Felmayer, G1
Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM1
Heyes, MP; Markey, SP; Saito, K3
Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE1
Frank, JA; Gravell, M; Heyes, MP; Jordan, EK; Lee, K; Markey, SP; Saito, K; Snoy, PJ1
Carlà, V; De Luca, G; Moroni, F; Politi, V; Russi, P1
Morgan, PF1
Auer, RN; Heyes, MP; Leonard, C; Markey, SP; Papagapiou, M2
Heyes, MP; Nowak, TS1
Heyes, MP; Quearry, BJ1
Boni, RL; Heyes, MP; Markey, SP; Yergey, JA1
Connick, JH; Hall, E; Lombardi, G; Moroni, F; Stone, TW; Taylor, A1
Abramson, FP; Bacher, JD; Boni, RL; Heyes, MP; Ji, XD; Markey, SP; Yergey, JA1
During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Matson, WR; Roth, RH; Swartz, KJ1
Murata, K; Shibata, K1
April, M; Blackmore, D; Eckhaus, M; Gravell, M; Heyes, MP; London, WT; Markey, SP; Vickers, JH; Yergey, JA1
Beninger, RJ; Boegman, RJ; Jhamandas, K1
Cotton, P1
Beninger, RJ; Bialik, M; Boegman, RJ; Jhamandas, K1
Dedhia, M; Heyes, MP; Lackner, A; Mefford, IN; Quearry, BJ1
Bird, SJ; Culligan, NW; Edelsohn, L; Garcia, CA; Heiman-Patterson, TD; Heyes, MP; Parry, GJ; Shy, ME; Tatarian, GT; Varga, J1
Carassale, GL; Carlà, V; Cortesini, C; Lombardi, G; Moroni, F; Pellegrini, D1
Carlà, V; Etienne, P; Lal, S; Lombardi, G; Moroni, F; Nair, NP1
Heyes, MP; Markey, SP; Quearry, BJ1
During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Roth, RH1
During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Roth, RH; Swartz, KJ1
Kiyohara, Y; Sano, K; Shin, M; Shirasawa, K; Umezawa, C1
Heyes, MP; Lane, C; Markey, SP; Rubinow, D1
Schwarcz, R; Speciale, C; Ungerstedt, U1
Hayakawa, T; Iwai, K; Murata, K; Shibata, K1
Dykens, JA; Stern, A; Sullivan, SG1
Heyes, MP; Kim, P; Markey, SP1
Carlà, V; Lombardi, G; Moroni, F1
Heyes, MP; Markey, SP1
Shibata, Y; Takeuchi, F; Tsubouchi, R1
Barrett, J; Lloyd, GM1
Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA1
Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K1
Boni, RL; Markey, SP; Naritsin, DB1
Bingel, SA; Hampton, M; Harley, RA; Heyes, MP; Ludwicka, A; Maize, J; Ohba, T; Silver, RM; Smith, T1
Crowley, JS; Heyes, MP; Markey, SP; Nowak, TS; Quearry, BJ; Saito, K; Saito, M; Suyama, K1
Pascoe, M1
Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH1
Kitoh, J; Kuroda, T; Masuda, K; Mizobuchi, M; Nakano, K; Takahashi, S1
Heyes, MP; Markey, SP; Nowak, TS; Saito, K1
Chen, CY; Crowley, JS; Heyes, MP; Markey, SP; Masana, M; Saito, K1
Flanagan, EM; Iyer, R; Madge, DJ; Reinhard, JF; Salter, M1
Giulian, D; Li, J; Li, X; Lin, SN; Noonan, C; Schwarcz, R; Tom, D; Wendt, E; Yu, J1
Espey, MG; Gajdusek, DC; Gibbs, CJ; Moffett, JR; Namboodiri, MA; Narayanan, R; Venkateshan, CN1
Heyes, MP; Klipple, GL; Lipnick, RN; Salazar, AM; Sfikakis, PP; Tsokos, GC; Vogelgesang, SA; West, SG1
Batshaw, ML; Heyes, MP; Hopkins, K; McLaughlin, BA; Oster-Granite, ML; Robinson, MB1
Apelqvist, G; Bengtsson, F; Bergqvist, PB; Butterworth, RF; Heyes, MP1
Fuchs, D; Gisslén, M; Hagberg, L; Larsson, M; Norkrans, G; Wachter, H1
Fornstedt-Wallin, B; Fredriksson, G; Luthman, J; Vänerman, E1
Bengtsson, F; Bergqvist, PB; Heyes, MP1
Blinder, K; Gajdusek, DC; Gibbs, CJ; Gravell, M; Moffett, JR; Namboodiri, AM; Narayanan, R; Venkateshan, CN1
Achim, CL; Heyes, MP; Major, EO; Markey, SP; Saito, K; Wiley, CA1
Klein, TL; Lunte, SM; Malis, M; Palmer, SD; Weber, PL1
Armati, PJ; Brew, BJ; Kerr, SJ; Pemberton, LA; Smythe, G; Tattam, B1
Dong-Ryul, L; Furukawa, S; Kondo, H; Nakano, K1
Chaudhri, G; Hunt, NH; Moore, DE; Sanni, LA; Stocker, R; Tattam, BN; Thomas, SR1
Reinhard, JF1
Dong-Ruyl, L; Nakano, K; Sawada, M1
Blinder, KL; Moffett, JR; Namboodiri, MA; Venkateshan, CN1
Goodman, CB; Heyliger, SO; Ngong, JM; Soliman, KF1
Block, E; Burchard, JF; Heyes, MP; Nguyen, DH; Richard, L; Young, SN1
Grant, RS; Kapoor, V; Matanovic, G; Passey, R; Smythe, G1
Fornstedt-Wallin, B; Fredriksson, G; Lundström, J; Luthman, J; Schwarcz, R1
Bengtsson, F1
Crawley, J; Dobbie, M; Marsh, K; Surtees, R; Waruiru, C1
Stone, TW1
Allen, RH; Altfeld, M; Kreuzer, KA; Look, MP; Riezler, R; Rockstroh, JK; Sauerbruch, T; Stabler, SP1
Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H1
Brown, OR; Dale, WE; Dang, Y1
Arun, P; Deepadevi, KV; Kurup, PA; Manojkumar, V; Ravikumar, A1
Baraldi, M; Cannazza, G; Zanoli, P1
Fukuwatari, T; Shibata, K; Sugimoto, E1
Nicholls, T; Nitsos, I; Smythe, G; Walker, DW1
Calvani, M; Chiarugi, A; Meli, E; Moroni, F; Traggiai, E1
Fukuwatari, T; Hayakawa, F; Morikawa, Y; Shibata, K; Sugimoto, E1
Bjugstad, KB; Freed, CR; Goodman, S; Zawada, WM1
Buczko, W; Pawlak, D; Tankiewicz, A1
Buczko, W; Mysliwiec, P; Pawlak, D; Tankiewicz, A1
Buczko, W; Myśliwiec, M; Myśliwiec, P; Pawlak, D1
Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K1
Heyes, MP; Kita, T; Markey, SP; Morrison, PF1
Egashira, Y; Fukuoka, S; Ishiguro, K; Sanada, H; Shibata, K; Tanabe, A; Yanagihara, K1
Fukuwatari, T; Morikawa, Y; Shibata, K; Sugimoto, E1
Dayrell-Hart, B; Djali, S; Drobatz, KJ; Heyes, MP; Holt, DE; Robinson, MB; Washabau, RJ1
Bianchi, R; Fallarino, F; Fioretti, MC; Grohmann, U; Orabona, C; Puccetti, P; Spreca, A; Vacca, C1
Brew, BJ; Guillemin, GJ1
Fukuwatari, T; Shibata, K; Sugimoto, E; Suzuki, Y1
Kurup, PA; Kurup, RK1
Moffett, JR; Namboodiri, MA1
Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW1
Bwanaisa, L; Day, NP; Hunt, NH; Kayira, K; Medana, IM; Njobvu, A; Salahifar-Sabet, H; Smythe, G; Stocker, R; Taylor, TE; Turner, GD1
HENDERSON, LM; WILSON, RG1
Cerstiaens, A; De Loof, A; Huybrechts, J; Kotanen, S; Lebeau, I; Meylaers, K; Schoofs, L1
Anantha, S; Begley, TP; Colabroy, K; Gerdes, S; Goral, V; Kurnasov, O; Osterman, A1
Asano, E; Chakraborty, PK; Chugani, DC; Chugani, HT; Juhász, C; Mangner, TJ; Muzik, O; Padhye, UN; Shah, A; Sood, S1
Fukuwatari, T; Sasaki, R; Shibata, K; Wada, H1
HENDERSON, LM; SCHAYER, RW1
Fukuwatari, T; Kitamura, J; Ohta, M; Sasaki, R; Shibata, K1
Egashira, Y; Fukuoka, S; Fukuwatari, T; Ishiguro, K; Sanada, H; Shibata, K; Tanabe, A1
Fukuoka, S; Fukuwatari, T; Ohsaki, S; Sasaki, R; Shibata, K1
Cai, T; Chen, A; Di Prospero, NA; Du, F; Guidetti, P; Melendez-Ferro, M; Sapko, MT; Schwarcz, R; Tagle, DA; Whetsell, WO; Yu, P1
Rho, JM1
HENDERSON, LM; HIRSCH, HM1
HENDERSON, LM; JOHNSON, BC; RAMASARMA, GB1
Egashira, Y; Morise, A; Murotani, G; Saito, K; Sanada, H; Sato, M; Tanabe, A; Uehara, K1
Brown, AR; Kranz, DM; Roy, EJ; Takikawa, O; Thomas, DL1
Noakes, R; Spelman, L; Williamson, R1
Perez-De La Cruz, V; Santamaria, A1
Bale, S; Begley, TP; Crane, BR; Ealick, SE; Kang, SA; Mukherjee, T; Zhang, Y1
Cimadamore, F; Orsomando, G; Perozzi, S; Pucci, L; Raffaelli, N1
Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N1
Egashira, Y; Saito, K; Sanada, H; Sato, M1
Bosmans, E; Kubera, M; Maes, M; Mihaylova, I; Ruyter, MD1
HENDERSON, LM1
Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J1
Fukuwatari, T; Shibata, K2
Fotopoulou, C; Hasper, D; Pschowski, R; Reinke, P; Schefold, JC; Schuett, C; Volk, HD; von Haehling, S; Zeden, JP1
Egashira, Y; Sanada, H; Sasaki, N1
Guidetti, P; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R1
Fukuwatari, T; Kurata, K; Shibata, K1
Fülöp, F; Klivényi, P; Toldi, J; Vámos, E; Vécsei, L; Zádori, D1
Buczko, W; Dadan, J; Myśliwiec, H; Myśliwiec, P; Pawlak, D; Pawlak, K1
Mysliwiec, M; Pawlak, D; Pawlak, K1
Dantzer, R; Kelley, KW; Lawson, MA; Miller, AH; Raison, CL; Saito, K; Spivey, JR; Vogt, G; Woolwine, BJ1
Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R1
Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP1
Chen, Y; Guillemin, GJ; Meininger, V1
Kincses, ZT; Toldi, J; Vécsei, L1
Bien, B; Gulaj, E; Pawlak, D; Pawlak, K1
Bieber, T; Brenk, M; Koch, S; Scheler, M; von Bubnoff, D; Wilms, H1
Bernstein, HG; Bielau, H; Bogerts, B; Brisch, R; Gos, T; Guillemin, GJ; Mawrin, C; Meyer zu Schwabedissen, L; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M1
Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H1
Ammer, J; Andreesen, R; Edinger, M; Holler, B; Holler, E; Kreutz, M; Landfried, K; Oefner, PJ; Peter, K; Schulz, U; Waldhier, MC; Wolff, D; Zhu, W1
Azechi, H; Board, M; Yamamoto, T1
Du Preez, JL; Emsley, R; Harvey, BH; Möller, M1
Du Preez, JL; Harvey, BH; Möller, M1
Tan, L; Yu, JT1
Darlington, LG; Stone, TW; Stoy, N1
Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ1
Fukuwatari, T; Kondo, R; Sano, M; Shibata, K1
Adams, S; Ahrendt, T; Bode, HB; Guillemin, GJ; Oezen, I; Opitz, CA; Platten, M; Radlwimmer, B; Sahm, F; von Deimling, A; Wick, W1
Fukuwatari, T; Funakoshi, H; Kadota, E; Kanai, M; Nakamura, T; Sano, M; Shibata, K; Terakata, M1
Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES1
Dijkhuis, A; Johnston, SL; Karlas, JA; Kulik, W; Lutter, R; Molenkamp, R; Smids, BS; Sterk, PJ; van de Pol, MA; van der Sluijs, KF; van der Zee, JS; van Eijk, HW; Wolthers, KC1
Bergareche, A; Buxbaum, JD; Gorostidi, A; López de Munain, A; Makarov, V; Martí-Massó, JF; Paisán-Ruiz, C; Poza, JJ; Ruiz-Martinez, J; Striano, P1
Fukuwatari, T; Morita, N; Shibata, K; Shibata, Y1
Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH1
Aguesse, A; Castellano, B; Darmaun, D; Ferchaud-Roucher, V; Nael, C; Poupeau, G; Sano, M1
Banister, SD; Guillemin, GJ; Karl, T; Kassiou, M; Lim, CK; Purves-Tyson, T; Weickert, CS; Zavitsanou, K1
Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE1
Adams, S; Braidy, N; Brew, BJ; Bustamante, S; Guillemin, GJ; Lim, CK; McDonald, KL; Sundaram, G; Teo, C; Zinger, A1
Andreassen, OA; Brundin, L; Dahl, J; Malt, UF; Ormstad, H; Sandvik, L; Verkerk, R1
Drewes, JL; Gama, L; Graham, DR; Li, M; Liao, Z; Meulendyke, KA; Notarangelo, FM; Schwarcz, R; Tarwater, PM; Ubaida-Mohien, C; Witwer, KW; Zink, MC1
Bertuch, AA; Polleys, EJ1
Elizondo, G; García-Lara, L; González-Esquivel, D; Pérez-Severiano, F; Segovia, J1
Frugier, T; Guillemin, GJ; Heng, B; Lim, CK; Morganti-Kossmann, MC; Rosenfeld, JV; Sundaram, G; Tan, M; Walker, DW; Yan, EB1
Budac, DP; Elfving, B; Eskelund, A; Fischer, CW; Liebenberg, N; Tillmann, S; Wegener, G1
Bipath, P; Levay, PF; Viljoen, M1
Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE1
Buttar, HS; Nayak, BN1
de Bie, J; Grant, R; Guest, J; Guillemin, GJ1
Kaminski, T; Michalowska, M; Oksztulska-Kolanek, E; Pawlak, D; Znorko, B1
Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M1
Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M1
Budac, DP; Elfving, B; Eskelund, A; Sanchez, C; Wegener, G1
Braidy, N; Brew, BJ; Guillemin, GJ; Lee, JM; Lovejoy, D; Rowe, DB; Tan, V1
Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R1
Allorge, D; Caiazzo, R; Favennec, M; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Raverdy, V; Verbanck, M; Verkindt, H; Yengo, L1
Bezard, E; Camus, SM; Ceci, A; Fuertig, R; Hengerer, B; Luippold, AH1
Bhat, M; Erhardt, S; Orhan, F; Piehl, F; Sandberg, K; Schwieler, L; Ståhl, S; Svensson, C1
Al-Dhabi, NA; Bai, M; Duraipandiyan, V; Liu, G; Liu, H; Oso, AO; Tossou, MC; Wu, X; Xi, Q; Xu, K; Yin, Y1
Bhat, M; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, ME; Landén, M; Schuppe-Koistinen, I; Schwieler, L; Wetterberg, L1
Gabriele, S; Gevi, F; Persico, AM; Zolla, L1
Chiang, IT; Chiou, TW; Harn, HJ; Hsieh, DK; Lin, SY; Lin, SZ; Liu, JW; Rajamani, K; Wu, CH; You, DH1
Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Kapfhammer, HP; Maget, A; Mangge, H; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, B; Reininghaus, EZ; Schütze, G; Schwarz, M; Zelzer, S1
Anderson, G; Carvalho, AF; Geffard, M; Kanchanatawan, B; Maes, M; Ruxrungtham, K; Sirivichayakul, S1
Ablasser, K; Alesutan, I; Belyavskiy, E; Brussee, H; Catena, C; Fahrleitner-Pammer, A; Grübler, MR; Kolesnik, E; Lewinski, DV; März, W; Meinitzer, A; Pieske, B; Pieske-Kraigher, E; Pilz, S; Schwetz, V; Sechi, LA; Tomaschitz, A; Trummer, C; Verheyen, N; Voelkl, J1
Chugani, DC; Drewes, JL; Graham, DR; Kannan, S; Lesniak, WG; Nance, E; Rangaramanujam, K; Singh, S; Williams, M; Zhang, Z1
Hanna-Rose, W; Holleran, LM; McReynolds, MR; Wang, W1
Parasram, K1
Leonard, BE1
Aden, K; Al-Massad, N; Bethge, J; Häsler, R; Krawczak, M; Moll, N; Nikolaus, S; Rehman, A; Rosenstiel, P; Schreiber, S; Schulte, B; Schulte, DM; Schütze, G; Schwarz, MJ; Szymczak, S; Thieme, F; Tran, F; Waetzig, GH1
Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A1
Makino, R; Okuyama, H; Tachibana, T; Tomonaga, S1
Czarny, P; Galecki, P; Sliwinski, T; Wigner, P1
Chen, B; Guo, J; He, S; Hu, J; Hu, L; Huang, X; Li, X; Qi, Y; Shang, D; Wang, J; Wen, Y1
Duan, KM; Huang, Z; Ma, JH; Wang, SY; Yu, H; Zhou, Y1
Arnhard, K; Fuchs, D; Koal, T; Oberacher, H; Pitterl, F; Sperner-Unterweger, B1
Bryn, V; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R1
Shibata, K1
Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H1
Cline, MA; Kadomoto, Y; Khan, MSI; Makino, R; Tachibana, T1
Allers, KA; Doolin, K; Farrell, C; Frodl, T; Harkin, A; Liesener, A; O'Hanlon, E; O'Keane, V; Pleiner, S; Roddy, D; Tozzi, L1
Arnone, D; Dantzer, R; Salem, H; Saraykar, S; Selvaraj, S; Teixeira, AL1
Kanchanatawan, B; Maes, M1
Bryn, V; Halvorsen, B; Isaksen, J; Maes, M; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R1
Badawy, AA1
Botticelli, A; Cerbelli, B; Federica, M; Lionetto, L; Marchetti, P; Nuti, M; Pisano, A; Salati, M; Simmaco, M; Zizzari, I1
Atzori, M; García-Oscos, F; Pérez-Padilla, EA; Pineda, JC; Ramírez, LA; Salgado, H1
Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y1
Carrillo Mora, P; García Muñoz, I; García-Juárez, B; Gómez-Manzo, S; González-Esquivel, D; Jiménez Herrera, B; Marcial-Quino, J; Pérez de la Cruz, G; Pérez de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Ramos-Chávez, LA; Ríos, C; Roldán-Roldán, G; Sánchez Chapul, L1
Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M1
Böhmová, A; Horáček, J; Kodym, P; Krsek, D; Mikoška, M; Syslová, K; Tejkalová, H; Vacek, L; Vondroušová, J1
Chabielska, E; Kamiński, T; Kramkowski, K; Leszczyńska, A; Marcińczyk, N; Misztal, T; Pawlak, D1
Bhat, M; Blennow, K; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, M; Landén, M; Schwieler, L; Wetterberg, L; Zetterberg, H1
Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R1
Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H1
Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM1
Bloch, W; Hardt, L; Joisten, N; Kiesl, D; Knoop, A; Koliamitra, C; Kummerhoff, F; Metcalfe, AJ; Schenk, A; Thevis, M; Walzik, D; Zimmer, P1
Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R1
Cseh, EK; Janáky, T; Kecskeméti, G; Kormány, R; Rajda, C; Szabó, E; Szabó, Z; Tömösi, F; Vécsei, L1
Coppens, V; De Picker, L; Kampen, JK; Morrens, M1
Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS1
Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C; Misiak, B; Savitz, JB1
Gökmen, V; Yılmaz, C1
Cao, B; Chen, Y; McIntyre, RS; Pan, Z; Ren, Z; Wang, D1
Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM1
Chiappelli, J; Cui, Y; Hong, LE; Huang, J; Kochunov, P; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y1
Cathomas, F; Guetter, K; Kaiser, S; Klaus, F; Seifritz, E1
Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y1
Hoffman, WH; Lee, N; Whelan, SA1
Braidy, N; Guillemin, GJ; Joisten, N; Ruas, JL; Zimmer, P1
Janczarek, I; Kędzierski, W; Kowalik, S; Sadok, I; Staniszewska, M1
Bou Khalil, R; El Khoury, R1
Ciapała, K; Mika, J; Rojewska, E1
Anderson, EW; Aranow, C; Diamond, B; Fishbein, J; Furie, RA; Hong, J; Mackay, M; Roeser, J; Volpe, BT1
Anglicheau, D; Bignon, Y; Cippà, PE; Fohlen, B; Galichon, P; Hertig, A; Karras, A; Lenoir, O; Nadour, Z; Naesens, M; Nemazanyy, I; Pallet, N; Poindessous, V; Rinaldi, A; Weill-Raynal, P1
Bugiani, M; Dijkhuis, A; Duitman, JW; Geeraerts, Z; Guo, L; Lutter, R; Nossent, EJ; Roos, E; Schurink, B; van der Valk, P; van Vught, L; Vaz, FM; Vlaar, AP; Yeh, SR1
Brew, BJ; Guillemin, GJ; Heng, B; Krishnamurthy, S; Pires, AS; Sundaram, G1
Kurzepa, J; Parada-Turska, J; Wnorowska, S; Wnorowski, A1
Fukushima, T; Onozato, M; Sakamoto, T; Umino, M1
Altunçekiç Yıldırım, A; Ceran Serdar, C; Cihan, M; Doğan, Ö; Kurt, C; Serdar, MA1
Chen, J; Dang, E; Fang, H; Fu, M; Li, Q; Luo, Y; Ma, J; Qiao, P; Shao, S; Wang, G; Yin, W; Yu, J; Zhang, C; Zhang, J; Zhi, D1
Al-Hakeim, HK; Almulla, AF; Maes, M; Solmi, M; Tunvirachaisakul, C; Vasupanrajit, A; Verkerk, R1
Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA1
Abusoglu, S; Eryavuz Onmaz, D; Kuzu, M; Sivrikaya, A; Tezcan, D; Unlu, A; Yerlikaya, FH; Yilmaz, S1
Li, R; Long, X; Mu, L; Qiao, J; Wang, S; Zhang, C; Zhang, Y; Zhao, Y1
Aaseth, JO; Alexander, J; Hestad, K; Rootwelt, H1
Arnhard, K; Fuchs, D; Geisler, S; Gleissenthall, GV; Kemmler, G; Mechtcheriakov, S; Oberacher, H; Schurr, T; Unterberger, C1
Asakawa, T; Chen, W; Jia, X; Qin, W; Shi, Y1
Andrea, G; Cristina, B; Fabio, T; Luca, P; M C, BJ; Nicoletta, B; Sara, C; Silvia, A; Silvio, B; Veronica, R1
Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J1
Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO1
An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W1
Anderson, EW; Aranow, C; Arazi, A; Diamond, B; Furie, RA; Goodwin, S; Jin, Y; Mackay, M; Roeser, J; Shih, A; Volpe, B1
Fathi, M; Hajiesmaeili, M; Jazi, K; Klegeris, A; Mafi, Z; McElhinney, A; Mohamadkhani, A; Sayehmiri, F; Tavasol, A; Vakili, K; Yaghoobpoor, S1
Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM1
Benninga, MA; Boneh, RS; de Jonge, WJ; Emond, P; Ghiboub, M; Lefèvre, A; Sovran, B; Van Limbergen, JE; Verburgt, CM; Wine, E1
Buelow, KL; Chinnaiyan, P; Kant, S; Kesarwani, P; Miller, CR; Prabhu, A; Zhao, Y1
Ahmad, NS; Embong, H; Makpol, S; Nasaruddin, ML; Phing, AH; Wan Zaidi, WA1
Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J1
Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M1
Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y1
Abusoglu, S; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Unlu, A1
Ciampa, EJ; Clark, AJ; Etzrodt, V; Flores, BM; Huang, H; Parikh, SM; Saade, MC; Takakura, A; Vemireddy, V; Vu, KQ; Zandi-Nejad, K; Zsengellér, ZK1
Baranyi, A; Enko, D; Herrmann, M; Meinitzer, A; Michaelis, S; Schnedl, WJ; Schneider, C; Zelzer, S1
Mangoni, AA; Zinellu, A1

Reviews

38 review(s) available for quinolinic acid and tryptophan

ArticleYear
Mass spectrometric determinations of tryptophan and its metabolites.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Body Fluids; Gas Chromatography-Mass Spectrometry; Humans; Mass Spectrometry; Melatonin; Molecular Structure; Nervous System Diseases; Pineal Gland; Quinolinic Acid; Quinolinic Acids; Schizophrenia; Serotonin; Tryptophan

1991
Brain tryptophan/serotonin perturbations in metabolic encephalopathy and the hazards involved in the use of psychoactive drugs.
    Advances in experimental medicine and biology, 1999, Volume: 467

    Topics: Animals; Brain; Hepatic Encephalopathy; Humans; Indoles; Psychotropic Drugs; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptamines; Tryptophan

1999
Endogenous neurotoxins from tryptophan.
    Toxicon : official journal of the International Society on Toxinology, 2001, Volume: 39, Issue:1

    Topics: Animals; Humans; Kynurenine; Nervous System Diseases; Neurotoxins; Quinolinic Acid; Tryptophan

2001
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease.
    Redox report : communications in free radical research, 2002, Volume: 7, Issue:4

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Kynurenine; Quinolinic Acid; Tryptophan

2002
Tryptophan and the immune response.
    Immunology and cell biology, 2003, Volume: 81, Issue:4

    Topics: Animals; Dendritic Cells; Dioxygenases; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxygenases; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

2003
Tryptophan metabolites and brain disorders.
    Clinical chemistry and laboratory medicine, 2003, Volume: 41, Issue:7

    Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; Kynurenine; Quinolinic Acid; Tryptophan

2003
Basic science behind the catastrophic epilepsies.
    Epilepsia, 2004, Volume: 45 Suppl 5

    Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan

2004
Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
    Physiological research, 2007, Volume: 56, Issue:5

    Topics: Animals; Calcium; Cell Death; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acids; Humans; Huntington Disease; Inflammation; Kynurenic Acid; Mice; Mice, Transgenic; Mutation; Neurons; Nitro Compounds; Oxidative Stress; Propionates; Quinolinic Acid; Serotonin Plasma Membrane Transport Proteins; Trinucleotide Repeats; Tryptophan

2007
Tryptophan, adenosine, neurodegeneration and neuroprotection.
    Metabolic brain disease, 2007, Volume: 22, Issue:3-4

    Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Tryptophan

2007
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.
    Progress in neurobiology, 2010, Feb-09, Volume: 90, Issue:2

    Topics: Animals; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kynurenine; Mice; Mutation; Peptides; Quinolinic Acid; Rats; Receptors, Glutamate; Serotonin Plasma Membrane Transport Proteins; Tryptophan

2010
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:11

    Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenic Acid; Mitochondrial Diseases; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolinic Acid; Tryptophan

2009
Kynurenines, neurodegeneration and Alzheimer's disease.
    Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:8

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Structure; Nerve Degeneration; Plaque, Amyloid; Quinolinic Acid; Tryptophan

2010
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
    Journal of the neurological sciences, 2012, Dec-15, Volume: 323, Issue:1-2

    Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan

2012
An expanding range of targets for kynurenine metabolites of tryptophan.
    Trends in pharmacological sciences, 2013, Volume: 34, Issue:2

    Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Oxidation-Reduction; Quinolinic Acid; Tryptophan

2013
New insights into tryptophan and its metabolites in the regulation of bone metabolism.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2015, Volume: 66, Issue:6

    Topics: Animals; Bone and Bones; Humans; Kynurenine; Melatonin; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates

2015
Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.
    Neuropharmacology, 2017, Volume: 112, Issue:Pt B

    Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Quinolinic Acid; Tryptophan

2017
A review of the immunomodulatory role of dietary tryptophan in livestock and poultry.
    Amino acids, 2017, Volume: 49, Issue:1

    Topics: Animal Feed; Animals; Dietary Supplements; Humans; Immunity, Innate; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Livestock; Lymphocytes; Melatonin; Poultry; Quinolinic Acid; Serotonin; Swine; Tryptophan

2017
Phytochemical treatments target kynurenine pathway induced oxidative stress.
    Redox report : communications in free radical research, 2018, Volume: 23, Issue:1

    Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan

2018
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
    Psychiatria Danubina, 2017, Volume: 29, Issue:4

    Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progression; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide Synthase; Nitrosative Stress; Oxidative Stress; Quality of Life; Quinolinic Acid; Tryptophan

2017
The role of tryptophan metabolism in postpartum depression.
    Metabolic brain disease, 2018, Volume: 33, Issue:3

    Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolinic Acid; Tryptophan

2018
Organ Co-Relationship in Tryptophan Metabolism and Factors That Govern the Biosynthesis of Nicotinamide from Tryptophan.
    Journal of nutritional science and vitaminology, 2018, Volume: 64, Issue:2

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Diet; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Liver; Niacinamide; Nutritional Status; Pentosyltransferases; Quinolinic Acid; Tryptophan; Vitamin B Deficiency; Xanthurenates

2018
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
    Neuroscience and biobehavioral reviews, 2018, Volume: 92

    Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan

2018
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
    Biomedica : revista del Instituto Nacional de Salud, 2018, 09-01, Volume: 38, Issue:3

    Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Illness Behavior; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukins; Kynurenine; Models, Neurological; Models, Psychological; Neuroglia; Peripheral Nervous System; Pituitary-Adrenal System; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Social Isolation; Stress, Psychological; Toll-Like Receptor 4; Tryptophan; Vaccines

2018
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis.
    Schizophrenia research, 2020, Volume: 223

    Topics: Aged; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan

2020
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
    Molecular psychiatry, 2021, Volume: 26, Issue:7

    Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinolinic Acid; Tryptophan

2021
Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis.
    Neuroscience and biobehavioral reviews, 2021, Volume: 123

    Topics: Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan

2021
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
    Journal of neuroinflammation, 2021, Jun-14, Volume: 18, Issue:1

    Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Prognosis; Quality of Life; Quinolinic Acid; Signal Transduction; Tryptophan

2021
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
    Trends in molecular medicine, 2021, Volume: 27, Issue:10

    Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2021
The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives.
    International journal of molecular sciences, 2021, Oct-13, Volume: 22, Issue:20

    Topics: Analgesics; Animals; Biomarkers; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Metabolic Networks and Pathways; Neuralgia; Quinolinic Acid; Tryptophan

2021
Recent advances in clinical trials targeting the kynurenine pathway.
    Pharmacology & therapeutics, 2022, Volume: 236

    Topics: Humans; Kynurenine; Male; Nervous System Diseases; Quinolinic Acid; Tryptophan

2022
A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.
    Biomedical chromatography : BMC, 2022, Volume: 36, Issue:5

    Topics: Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
    Molecular psychiatry, 2022, Volume: 27, Issue:9

    Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan

2022
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases.
    Biomolecules, 2022, 07-18, Volume: 12, Issue:7

    Topics: Cytokines; Humans; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid; Tryptophan

2022
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information.
    Bioscience trends, 2022, Sep-17, Volume: 16, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Levodopa; Parkinson Disease; Quinolinic Acid; Tryptophan

2022
Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Humans; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Multiple Sclerosis; Quinolinic Acid; Tryptophan

2022
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
    International journal of molecular sciences, 2023, Mar-15, Volume: 24, Issue:6

    Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan

2023
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
    Journal of affective disorders, 2023, 10-15, Volume: 339

    Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2023
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.
    Frontiers in immunology, 2023, Volume: 14

    Topics: C-Reactive Protein; Humans; Kynurenine; Quinolinic Acid; Rheumatic Diseases; Tryptophan

2023

Trials

9 trial(s) available for quinolinic acid and tryptophan

ArticleYear
Quinolinic acid in patients with systemic lupus erythematosus and neuropsychiatric manifestations.
    The Journal of rheumatology, 1996, Volume: 23, Issue:5

    Topics: Adult; Brain Diseases; Demography; Electroencephalography; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Tomography, X-Ray Computed; Tryptophan

1996
Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
    AIDS research and human retroviruses, 2000, Sep-01, Volume: 16, Issue:13

    Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Tryptophan; Viral Load

2000
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
    The Journal of infectious diseases, 2003, Sep-15, Volume: 188, Issue:6

    Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; Picolinic Acids; Quinolinic Acid; Retrospective Studies; Tryptophan; Vietnam

2003
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
    Scandinavian journal of infectious diseases, 2010, Volume: 42, Issue:3

    Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Placebos; Protein Precursors; Quinolinic Acid; Sepsis; Serotonin; Shock, Septic; Treatment Outcome; Tryptophan

2010
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
    Clinical chemistry and laboratory medicine, 2017, Jun-27, Volume: 55, Issue:7

    Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyperparathyroidism, Primary; Inflammation; Kynurenine; Male; Quinolinic Acid; Tryptophan; Ventricular Remodeling

2017
Effect of l-tryptophan and its metabolites on food passage from the crop in chicks.
    Domestic animal endocrinology, 2018, Volume: 64

    Topics: Administration, Oral; Alanine; Animals; Asparagine; Chickens; Crop, Avian; Gastrointestinal Motility; Glycine; Kynurenic Acid; Male; Quinolinic Acid; Tryptophan

2018
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
    Psychoneuroendocrinology, 2019, Volume: 109

    Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha

2019
Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
    Exercise immunology review, 2020, Volume: 26

    Topics: Adult; Cross-Over Studies; Endurance Training; Exercise; Humans; Hydrocortisone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Male; Quinolinic Acid; Resistance Training; Transaminases; Tryptophan

2020
Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
    Inflammatory bowel diseases, 2023, 05-02, Volume: 29, Issue:5

    Topics: Child; Crohn Disease; Diet; Humans; Kynurenine; Melatonin; Prospective Studies; Quinolinic Acid; Remission Induction; Serotonin; Tryptophan

2023

Other Studies

224 other study(ies) available for quinolinic acid and tryptophan

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Quinolinate in brain and cerebrospinal fluid in rat models of congenital hyperammonemia.
    Pediatric research, 1992, Volume: 32, Issue:4

    Topics: Acetates; Ammonia; Animals; Brain; Disease Models, Animal; Hydroxyindoleacetic Acid; Male; Metabolism, Inborn Errors; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan; Urease

1992
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
    Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11

    Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1992
Poliovirus induces indoleamine-2,3-dioxygenase and quinolinic acid synthesis in macaque brain.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992, Volume: 6, Issue:11

    Topics: Animals; Brain; Enzyme Induction; Immunohistochemistry; Interferon-gamma; Macaca; Poliomyelitis; Poliovirus; Quinolinic Acid; Quinolinic Acids; Tryptophan; Tryptophan Oxygenase

1992
Immune activation and neuronal injury in AIDS.
    Trends in neurosciences, 1992, Volume: 15, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; HIV-1; Humans; Interferon-gamma; Nervous System Diseases; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Serotonin; Tryptophan

1992
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
    Arthritis and rheumatism, 1992, Volume: 35, Issue:9

    Topics: Adrenal Cortex Hormones; Adult; Aged; Eosinophilia-Myalgia Syndrome; Female; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Quinolinic Acid; Scleroderma, Systemic; Tryptophan

1992
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
    Neuroscience, 1992, Volume: 51, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan

1992
Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome.
    The Journal of rheumatology, 1992, Volume: 19, Issue:1

    Topics: Arthritis, Rheumatoid; Biopterins; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsaturated; Humans; Kynurenine; Neopterin; Plant Oils; Quinolinic Acid; Quinolinic Acids; Rapeseed Oil; Reference Values; Scleroderma, Systemic; Syndrome; Tryptophan

1992
Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.
    The Biochemical journal, 1992, May-01, Volume: 283 ( Pt 3)

    Topics: Carbon Isotopes; Cells, Cultured; Humans; Interferon-gamma; Macrophages; Quinolinic Acid; Quinolinic Acids; Recombinant Proteins; Tryptophan

1992
Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.
    Brain research, 1992, Jan-20, Volume: 570, Issue:1-2

    Topics: Animals; Atrophy; Brain; Cisterna Magna; Convulsants; Injections; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan

1992
The regulation of brain kynurenic acid content: focus on indole-3-pyruvic acid.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Biological Clocks; Brain; Brain Chemistry; Enzyme Induction; Humans; Indoles; Interferon Inducers; Kynurenic Acid; Mice; Neurotoxins; Organ Specificity; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tryptophan; Tryptophan Oxygenase

1991
Is quinolinic acid an endogenous excitotoxin in alcohol withdrawal?
    Medical hypotheses, 1991, Volume: 36, Issue:2

    Topics: Alcoholism; Animals; Brain; Humans; Kynurenic Acid; Models, Neurological; Quinolinic Acid; Quinolinic Acids; Substance Withdrawal Syndrome; Synaptic Transmission; Tryptophan

1991
Brain and plasma quinolinic acid in profound insulin-induced hypoglycemia.
    Journal of neurochemistry, 1990, Volume: 54, Issue:3

    Topics: Animals; Brain; Catecholamines; Corpus Striatum; Dialysis; Hydroxyindoleacetic Acid; Hypoglycemia; Insulin; Male; Osmolar Concentration; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan

1990
Delayed increases in regional brain quinolinic acid follow transient ischemia in the gerbil.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1990, Volume: 10, Issue:5

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dopamine; Female; Gerbillinae; Homovanillic Acid; Hydroxyindoleacetic Acid; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Serotonin; Time Factors; Tryptophan

1990
Increased L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid concentrations in cerebral cortex following systemic endotoxin administration.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Brain Chemistry; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Quinolinic Acid; Quinolinic Acids; Serotonin; Stimulation, Chemical; Tryptophan

1991
Effects of profound insulin-induced hypoglycemia on quinolinic acid in hippocampus and plasma.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Brain Chemistry; Brain Diseases, Metabolic; Dialysis; Electroencephalography; Extracellular Space; Hippocampus; Hydroxyindoleacetic Acid; Hypoglycemia; Insulin; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Serotonin; Tryptophan

1991
The effect of aluminum on rat brain and liver quinolinic acid concentrations.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Alum Compounds; Animals; Cerebral Cortex; Liver; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan; Tryptophan Oxygenase

1991
Stable isotope-labeled tryptophan as a precursor for studying the disposition of quinolinic acid in rabbits.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Deuterium; Half-Life; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rabbits; Tissue Distribution; Tryptophan

1991
Indolic and kynurenine pathway metabolites of tryptophan in rat brain: effect of precursor availability on in vivo release.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Indoles; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan

1991
Efficiency of exogenous quinolinic acid, a metabolite of tryptophan, as a niacin precursor in rats.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Male; Niacin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1991
Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.
    Brain research, 1990, Oct-29, Volume: 531, Issue:1-2

    Topics: Animals; Brain; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Reference Values; Retroviruses, Simian; Simian Acquired Immunodeficiency Syndrome; Tryptophan

1990
The eosinophilia-myalgia syndrome.
    Annals of internal medicine, 1990, May-15, Volume: 112, Issue:10

    Topics: Animals; Eosinophilia; Female; Humans; Middle Aged; Muscular Diseases; Pain; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Syndrome; Tryptophan

1990
Neurotoxicity of tryptophan metabolites.
    Annals of the New York Academy of Sciences, 1990, Volume: 585

    Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Kynurenic Acid; Male; NADP; Nervous System Diseases; Neurons; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1990
AIDS dementia may be linked to metabolite of tryptophan.
    JAMA, 1990, Jul-18, Volume: 264, Issue:3

    Topics: AIDS Dementia Complex; Animals; Humans; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Tryptophan

1990
Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.
    Brain research, 1990, Oct-08, Volume: 529, Issue:1-2

    Topics: 3-Hydroxyanthranilic Acid; Acetylcholine; Animals; Brain; Cerebral Cortex; In Vitro Techniques; Kynurenic Acid; Male; Neurotoxins; Parietal Lobe; Picolinic Acids; Potassium; Quinolines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1990
Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral status.
    Annals of neurology, 1990, Volume: 27, Issue:6

    Topics: Animals; Catecholamines; Kynurenic Acid; Macaca; Macaca mulatta; Pyridines; Quinolinic Acid; Quinolinic Acids; Retroviridae Infections; Tryptophan

1990
Peripheral neuropathy associated with eosinophilia-myalgia syndrome.
    Annals of neurology, 1990, Volume: 28, Issue:4

    Topics: Adult; Biopsy; Demyelinating Diseases; Drug Contamination; Eosinophilia; Female; Humans; Middle Aged; Muscles; Muscular Diseases; Nerve Degeneration; Peripheral Nervous System Diseases; Quinolinic Acid; Quinolinic Acids; Sural Nerve; Syndrome; Tryptophan

1990
Content of quinolinic acid and of other tryptophan metabolites increases in brain regions of rats used as experimental models of hepatic encephalopathy.
    Journal of neurochemistry, 1986, Volume: 46, Issue:3

    Topics: Acetates; Animals; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Disease Models, Animal; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Portacaval Shunt, Surgical; Probenecid; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan

1986
Increase in the content of quinolinic acid in cerebrospinal fluid and frontal cortex of patients with hepatic failure.
    Journal of neurochemistry, 1986, Volume: 47, Issue:6

    Topics: Aged; Cerebral Cortex; Hepatic Encephalopathy; Humans; Hydroxyindoleacetic Acid; Middle Aged; Pyridines; Quinolinic Acid; Quinolinic Acids; Serotonin; Tryptophan

1986
Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex.
    Brain research, 1989, Jul-03, Volume: 491, Issue:1

    Topics: Animals; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Kynurenine; Mice; Mice, Inbred C57BL; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Time Factors; Tryptophan

1989
Quinolinic acid concentrations in striatal extracellular fluid reach potentially neurotoxic levels following systemic L-tryptophan loading.
    Brain research, 1989, Jan-09, Volume: 476, Issue:2

    Topics: Animals; Corpus Striatum; Extracellular Space; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Time Factors; Tryptophan

1989
Neuroactive metabolites of L-tryptophan, serotonin and quinolinic acid, in striatal extracellular fluid. Effect of tryptophan loading.
    FEBS letters, 1989, Apr-24, Volume: 247, Issue:2

    Topics: Animals; Corpus Striatum; Dialysis; Dose-Response Relationship, Drug; Extracellular Space; Kinetics; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan

1989
Tryptophan metabolism by the isolated rat liver cells--effects of leucine and its metabolites.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1989, Volume: 59, Issue:1

    Topics: Acetoacetates; Animals; In Vitro Techniques; Keto Acids; Leucine; Liver; NAD; Pentosyltransferases; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1989
Cerebrospinal fluid quinolinic acid concentrations are increased in acquired immune deficiency syndrome.
    Annals of neurology, 1989, Volume: 26, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Humans; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Tryptophan

1989
Production of extracellular quinolinic acid in the striatum studied by microdialysis in unanesthetized rats.
    Neuroscience letters, 1989, Oct-09, Volume: 104, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Animals; Corpus Striatum; Extracellular Space; Ibotenic Acid; Kynurenic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1989
Effect of dietary orotic acid on the levels of liver and blood NAD in rats.
    Journal of nutritional science and vitaminology, 1985, Volume: 31, Issue:3

    Topics: Animals; Body Weight; Creatinine; Diet; DNA; Fats; Liver; Male; NAD; Niacin; Organ Size; Orotic Acid; Proteins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Time Factors; Tryptophan

1985
Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate.
    Biochemical pharmacology, 1987, Jan-15, Volume: 36, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Catalase; Hydrogen-Ion Concentration; Kinetics; ortho-Aminobenzoates; Oxazines; Oxidation-Reduction; Oxygen Consumption; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Superoxide Dismutase; Tryptophan

1987
Systemic lipopolysaccharide and pokeweed mitogen increase quinolinic acid content of mouse cerebral cortex.
    Journal of neurochemistry, 1988, Volume: 51, Issue:6

    Topics: Animals; Cerebral Cortex; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Tryptophan

1988
The physiopathological role of quinolinic acid in the mammalian central nervous system.
    Annali dell'Istituto superiore di sanita, 1988, Volume: 24, Issue:3

    Topics: Aging; Alzheimer Disease; Animals; Cerebral Cortex; Gas Chromatography-Mass Spectrometry; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Male; Portacaval Shunt, Surgical; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1988
Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: effects of systemic L-tryptophan administration on brain and blood quinolinic acid concentrations.
    Analytical biochemistry, 1988, Volume: 174, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Gas Chromatography-Mass Spectrometry; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Standards; Reference Values; Tryptophan

1988
Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro.
    The Biochemical journal, 1985, Apr-15, Volume: 227, Issue:2

    Topics: Animals; Kinetics; Kynurenic Acid; Liver; Male; Oxidoreductases Acting on CH-NH Group Donors; Phosphotransferases; Picolinic Acids; Pyridoxal Kinase; Pyridoxaminephosphate Oxidase; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptamines; Tryptophan; Xanthurenates

1985
Fasciola hepatica: inhibition of phosphoenolpyruvate carboxykinase, and end-product formation by quinolinic acid and 3-mercaptopicolinic acid.
    Experimental parasitology, 1983, Volume: 56, Issue:2

    Topics: Acetates; Animals; Dose-Response Relationship, Drug; Fasciola hepatica; Lactates; Lactic Acid; Phosphoenolpyruvate Carboxykinase (GTP); Picolinic Acids; Propionates; Pyridines; Pyruvate Kinase; Quinolinic Acid; Quinolinic Acids; Succinates; Succinic Acid; Tryptophan

1983
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
    Biological psychiatry, 1995, Apr-15, Volume: 37, Issue:8

    Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Thinness; Tryptophan

1995
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
    Journal of neurochemistry, 1995, Volume: 65, Issue:5

    Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan

1995
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
    Analytical chemistry, 1995, Mar-01, Volume: 67, Issue:5

    Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates

1995
6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.
    Neuroscience letters, 1994, Sep-12, Volume: 178, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Immune System; Kynurenine; Lung; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

1994
A murine model of the eosinophilia-myalgia syndrome induced by 1,1'-ethylidenebis (L-tryptophan).
    The Journal of clinical investigation, 1994, Volume: 93, Issue:4

    Topics: Animals; Disease Models, Animal; Eosinophilia-Myalgia Syndrome; Fascia; Female; Mice; Mice, Inbred C57BL; Muscles; Quinolinic Acid; Tryptophan

1994
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
    Journal of neurochemistry, 1993, Volume: 61, Issue:6

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Carbon Isotopes; Dioxygenases; Female; Gerbillinae; Hydrolases; Ischemic Attack, Transient; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Lyases; Lymphocyte Activation; Mitochondria; Mixed Function Oxygenases; Organ Specificity; Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Synaptosomes; Transaminases; Tryptophan; Tryptophan Oxygenase

1993
Huntington's disease and low tryptophan diet.
    Medical hypotheses, 1993, Volume: 41, Issue:4

    Topics: Brain; Female; Humans; Huntington Disease; Models, Biological; Nerve Degeneration; Quinolinic Acid; Tryptophan

1993
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
    Brain : a journal of neurology, 1993, Volume: 116 ( Pt 6)

    Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

1993
High levels of quinolinic acid in brain of epilepsy-prone E1 mice.
    Brain research, 1993, Aug-13, Volume: 619, Issue:1-2

    Topics: Aging; Amino Acids; Animals; Cerebral Cortex; Epilepsy; Escherichia coli; Lipopolysaccharides; Methionine; Mice; Mice, Inbred Strains; Mice, Neurologic Mutants; Quinolinic Acid; Species Specificity; Threonine; Tryptophan

1993
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
    Journal of neurochemistry, 1993, Volume: 60, Issue:1

    Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Female; Gerbillinae; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Macrophages; Pokeweed Mitogens; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase

1993
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
    The Biochemical journal, 1993, Apr-01, Volume: 291 ( Pt 1)

    Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Carbolines; Cell Line; Harmine; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Macrophages; Quinolinic Acid; Rats; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha

1993
Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice.
    Biochemical pharmacology, 1996, Jan-26, Volume: 51, Issue:2

    Topics: Animals; Brain; Enzyme Inhibitors; Indoles; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

1996
Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996, May-15, Volume: 16, Issue:10

    Topics: Acquired Immunodeficiency Syndrome; Brain; Cells, Cultured; HIV-1; Humans; Neurotoxins; Phagocytes; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Time Factors; Tryptophan

1996
Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.
    Proceedings of the National Academy of Sciences of the United States of America, 1996, Feb-20, Volume: 93, Issue:4

    Topics: Cells, Cultured; DNA, Viral; Human T-lymphotropic virus 1; Humans; Interferon-gamma; Kynurenine; Macrophages; Monocytes; Neuroimmunomodulation; Polymerase Chain Reaction; Proviruses; Quinolinic Acid; Tryptophan

1996
Evidence of excitotoxicity in the brain of the ornithine carbamoyltransferase deficient sparse fur mouse.
    Brain research. Developmental brain research, 1995, Dec-21, Volume: 90, Issue:1-2

    Topics: Ammonia; Animals; Brain Damage, Chronic; Disease Models, Animal; Glutamine; Hair; Metabolism, Inborn Errors; Mice; Mice, Inbred Strains; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Quinolinic Acid; Tryptophan

1995
Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1996, Volume: 15, Issue:4

    Topics: Animals; Brain; Disease Models, Animal; Hepatic Encephalopathy; Male; Microdialysis; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

1996
Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Anti-HIV Agents; Biopterins; Chromatography, High Pressure Liquid; HIV Infections; HIV Seropositivity; Humans; Kynurenine; Neopterin; Quinolinic Acid; Radioimmunoassay; Time Factors; Tryptophan; Zidovudine

1996
Regulation of quinolinic acid in the normal rat brain by kynurenine pathway precursors.
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: 3-Hydroxyanthranilic Acid; Analysis of Variance; Animals; Cerebral Ventricles; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan

1996
Is quinolinic acid involved in the pathogenesis of hepatic encephalopathy?
    Advances in experimental medicine and biology, 1996, Volume: 398

    Topics: Animals; Brain; Cerebral Cortex; Disease Models, Animal; Extracellular Space; Hepatic Encephalopathy; Portacaval Shunt, Surgical; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Reference Values; Time Factors; Tryptophan

1996
Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys.
    Journal of neurovirology, 1996, Volume: 2, Issue:6

    Topics: Animals; Antibody Specificity; Cell Size; Cells, Cultured; Immunohistochemistry; Kynurenine; Macaca mulatta; Macrophages; Monocytes; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan

1996
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
    The Biochemical journal, 1996, Dec-01, Volume: 320 ( Pt 2)

    Topics: Astrocytes; Brain; Carbon Isotopes; Cells, Cultured; Fetus; Humans; Interferon-gamma; Isotope Labeling; Kynurenine; Macrophages; Microglia; Neurons; Neurotoxins; Quinolinic Acid; Recombinant Proteins; Tryptophan

1996
Capillary zone electrophoresis separation of tryptophan and its metabolites, including quinolinic acid.
    Journal of chromatography. B, Biomedical sciences and applications, 1997, Sep-12, Volume: 697, Issue:1-2

    Topics: Buffers; Edetic Acid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Quinolinic Acid; Reproducibility of Results; Spectrophotometry, Ultraviolet; Tryptophan

1997
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.
    Neurology, 1997, Volume: 49, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Aggregation; Cells, Cultured; Coloring Agents; Fetus; HIV-1; Humans; Immunohistochemistry; Kynurenine; L-Lactate Dehydrogenase; Macrophages; Microscopy, Electron; Quinolinic Acid; Trypan Blue; Tryptophan

1997
Stimulation of NGF production by tryptophan and its metabolites in cultured mouse astroglial cells.
    Brain research, 1997, Nov-28, Volume: 777, Issue:1-2

    Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Kynurenine; Mice; Mice, Inbred C3H; Nerve Growth Factors; Quinolinic Acid; Serotonin; Tryptophan

1997
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
    The American journal of pathology, 1998, Volume: 152, Issue:2

    Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

1998
Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid.
    Neurochemical research, 1998, Volume: 23, Issue:5

    Topics: Animals; Brain; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice; Mixed Function Oxygenases; Prosencephalon; Quinolinic Acid; Spinal Cord; Tryptophan; Tryptophan Oxygenase

1998
Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells.
    Neuroscience letters, 1998, Mar-06, Volume: 244, Issue:1

    Topics: Animals; Astrocytes; Cells, Cultured; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Quinolinic Acid; RNA, Messenger; Serotonin; Tryptophan

1998
Differential effects of kynurenine and tryptophan treatment on quinolinate immunoreactivity in rat lymphoid and non-lymphoid organs.
    Cell and tissue research, 1998, Volume: 293, Issue:3

    Topics: Animals; Immunohistochemistry; Injections, Intraperitoneal; Kynurenine; Lymphoid Tissue; Male; NAD; Organ Specificity; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

1998
The analgesic effects of tryptophan and its metabolites in the rat.
    Pharmacological research, 1998, Volume: 38, Issue:4

    Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates

1998
Effects of electromagnetic fields on the levels of biogenic amine metabolites, quinolinic acid, and beta-endorphin in the cerebrospinal fluid of dairy cows.
    Neurochemical research, 1998, Volume: 23, Issue:12

    Topics: Animals; beta-Endorphin; Biogenic Amines; Cattle; Dairying; Electromagnetic Fields; Female; Homovanillic Acid; Hydroxyindoleacetic Acid; Methoxyhydroxyphenylglycol; Quinolinic Acid; Tryptophan

1998
Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?
    Archives of biochemistry and biophysics, 1999, Dec-01, Volume: 372, Issue:1

    Topics: Animals; Benzamides; Cell Line; Dexamethasone; Enzyme Inhibitors; Interferon-gamma; Macrophage Activation; Macrophages; Mice; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tryptophan Oxygenase

1999
3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631.
    European journal of pharmacology, 1999, Dec-10, Volume: 386, Issue:1

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Brain; Dioxygenases; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Kynurenic Acid; Male; Oxygenases; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan

1999
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?
    The American journal of tropical medicine and hygiene, 2000, Volume: 62, Issue:2

    Topics: Antimalarials; Biopterins; Brain; Child; Child, Preschool; Chromatography, High Pressure Liquid; Endothelium; Gas Chromatography-Mass Spectrometry; Humans; Hydroxyindoleacetic Acid; Infant; Kenya; Malaria, Cerebral; Microglia; Neopterin; Nitrates; Nitrites; Quinolinic Acid; Tryptophan

2000
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
    American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:3

    Topics: Adult; Albuminuria; Animals; Carboxy-Lyases; Enzyme Inhibitors; Female; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Middle Aged; Mixed Function Oxygenases; Pentosyltransferases; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Tryptophan Oxygenase

2000
Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices.
    Free radical biology & medicine, 2000, Jul-15, Volume: 29, Issue:2

    Topics: Aerobiosis; Animals; Brain; In Vitro Techniques; Kynurenine; Liver; Male; NAD; Organ Specificity; Oxygen; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

2000
Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.
    Neurology India, 2000, Volume: 48, Issue:3

    Topics: Adult; Biogenic Monoamines; Brain Diseases; Brain Neoplasms; Digoxin; Epilepsy, Generalized; Erythrocytes; Fatty Acids, Nonesterified; Female; Glioma; Glycine Agents; Humans; Hydroxymethylglutaryl CoA Reductases; Kynurenic Acid; Magnesium; Male; Microvascular Angina; Middle Aged; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Parkinson Disease; Quinolinic Acid; Schizophrenia; Serum Albumin; Sodium-Potassium-Exchanging ATPase; Strychnine; Tryptophan; Tyrosine; Ubiquinone

2000
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
    Brain research bulletin, 2001, May-15, Volume: 55, Issue:2

    Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

2001
Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:6

    Topics: Animals; Antitubercular Agents; Diet; Eating; Liver; Male; NAD; NADP; Niacin; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tryptophan; Weight Gain

2001
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas.
    American journal of obstetrics and gynecology, 2001, Volume: 185, Issue:4

    Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retardation; Infusions, Intravenous; Kynurenic Acid; Placenta; Placental Insufficiency; Pregnancy; Pregnancy, Animal; Probability; Quinolinic Acid; Reference Values; Sensitivity and Specificity; Sheep; Tryptophan

2001
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
    Journal of neuroimmunology, 2001, Nov-01, Volume: 120, Issue:1-2

    Topics: Cell Death; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Hydrolases; Interferon-gamma; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Macrophages; Mixed Function Oxygenases; Monocytes; Neurons; Neurotoxins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Tryptophan; Tumor Necrosis Factor-alpha

2001
Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:10

    Topics: 3-Hydroxyanthranilic Acid; Adenine; Animals; Kidney; Kynurenic Acid; Liver; Male; NAD; Niacin; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Xanthurenates

2001
IGF-1 and bFGF reduce glutaric acid and 3-hydroxyglutaric acid toxicity in striatal cultures.
    Journal of inherited metabolic disease, 2001, Volume: 24, Issue:6

    Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Antagonists; Fibroblast Growth Factor 2; Glutarates; Growth Substances; Hydrogen-Ion Concentration; Immunohistochemistry; Insulin; Insulin-Like Growth Factor I; Male; Neostriatum; Nerve Degeneration; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

2001
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2001, Volume: 52, Issue:4 Pt 2

    Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan

2001
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
    Nephron, 2002, Volume: 90, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates

2002
Endogenous neurotoxine-quinolinic acid is increased in renal allograft recipients.
    Transplantation proceedings, 2002, Volume: 34, Issue:2

    Topics: Adult; Aged; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Neurotoxins; Quinolinic Acid; Reference Values; Renal Dialysis; Transplantation, Homologous; Tryptophan

2002
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
    International urology and nephrology, 2001, Volume: 33, Issue:2

    Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates

2001
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
    Journal of neurochemistry, 2002, Volume: 82, Issue:2

    Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflammation; Injections, Subcutaneous; Kidney; Kynurenine; Lipopolysaccharides; Liver; Lung; Mass Spectrometry; Models, Biological; Protein Binding; Quinolinic Acid; Serum Albumin; Tissue Distribution; Tritium; Tryptophan

2002
Identification and expression of a cDNA encoding human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and "quinolinate hypothesis".
    The Journal of biological chemistry, 2002, Sep-20, Volume: 277, Issue:38

    Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Carboxy-Lyases; COS Cells; DNA, Complementary; DNA, Recombinant; Humans; Kidney; Molecular Sequence Data; Niacin; Quinolinic Acid; Sequence Homology, Amino Acid; Swine; Tryptophan

2002
Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.
    Bioscience, biotechnology, and biochemistry, 2002, Volume: 66, Issue:6

    Topics: Animals; Diet; Fats; Fatty Liver; Feeding Behavior; Liver; Male; NAD; NADP; Niacin; Organ Size; Orotic Acid; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Vitamin B Deficiency; Weight Gain

2002
Cerebrospinal fluid glutamine, tryptophan, and tryptophan metabolite concentrations in dogs with portosystemic shunts.
    American journal of veterinary research, 2002, Volume: 63, Issue:8

    Topics: Alanine; Animals; Dietary Proteins; Dog Diseases; Dogs; Female; Glutamine; Hepatic Encephalopathy; Hydroxyindoleacetic Acid; Male; Portal System; Quinolinic Acid; Serine; Tryptophan

2002
T cell apoptosis by tryptophan catabolism.
    Cell death and differentiation, 2002, Volume: 9, Issue:10

    Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Autoimmune Diseases; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; fas Receptor; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Mitochondria; Quinolinic Acid; Self Tolerance; T-Lymphocytes; Th1 Cells; Thymus Gland; Tryptophan

2002
Identification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate.
    Bioscience, biotechnology, and biochemistry, 2002, Volume: 66, Issue:12

    Topics: Animals; Body Weight; Carboxy-Lyases; Diethylhexyl Phthalate; Feeding Behavior; Hexanols; Liver; Niacin; Quinolinic Acid; Rats; Tryptophan

2002
Hypothalamic digoxin, hemispheric chemical dominance, and Alzheimer's disease.
    The International journal of neuroscience, 2003, Volume: 113, Issue:3

    Topics: Aged; Albumins; alpha-Tocopherol; Alzheimer Disease; Ceruloplasmin; Digoxin; Dolichols; Dominance, Cerebral; Erythrocyte Membrane; Female; Free Radicals; Functional Laterality; Glycosaminoglycans; Humans; Hydroxymethylglutaryl CoA Reductases; Hypothalamus; Iron; Lysosomes; Magnesium; Male; Matched-Pair Analysis; Middle Aged; Phosphoprotein Phosphatases; Quinolinic Acid; Serotonin; Sodium-Potassium-Exchanging ATPase; Tryptophan

2003
Tryptophan-niacin relationship in Xanthomonas pruni.
    Journal of bacteriology, 1963, Volume: 85

    Topics: Niacin; Nicotinic Acids; Quinolinic Acid; Tryptophan; Xanthomonas

1963
Neurotoxic and neurobehavioral effects of kynurenines in adult insects.
    Biochemical and biophysical research communications, 2003, Dec-26, Volume: 312, Issue:4

    Topics: Animals; Apoptosis; Behavior, Animal; Cell Survival; Cells, Cultured; Diptera; Dose-Response Relationship, Drug; Grasshoppers; Insecta; Kynurenine; Lethal Dose 50; Nervous System; Neurons; Neurotoxicity Syndromes; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2003
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
    Chemistry & biology, 2003, Volume: 10, Issue:12

    Topics: Arylformamidase; Bacteria; Chromosomes, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Complementation Test; Hydrolases; Kinetics; Molecular Sequence Data; NAD; Oxidoreductases; Quinolinic Acid; Tryptophan

2003
Evaluation with alpha-[11C]methyl-L-tryptophan positron emission tomography for reoperation after failed epilepsy surgery.
    Epilepsia, 2004, Volume: 45, Issue:2

    Topics: Adolescent; Adult; Age Factors; Carbon Radioisotopes; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Humans; Male; Neocortex; Quinolinic Acid; Reoperation; Tomography, Emission-Computed; Treatment Failure; Tryptophan

2004
Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
    Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Eating; Liver; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Predictive Value of Tests; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Weaning; Weight Gain

2004
The conversion of deutero-N15 tryptophan to quinolinic acid by the rat.
    The Journal of biological chemistry, 1952, Volume: 195, Issue:2

    Topics: Animals; Quinolines; Quinolinic Acid; Rats; Tryptophan

1952
Effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in mice.
    Experimental animals, 2004, Volume: 53, Issue:1

    Topics: Analysis of Variance; Animals; Body Weights and Measures; Diet; Diethylhexyl Phthalate; Mice; Niacin; Quinolinic Acid; Tryptophan

2004
Identification and expression of alpha cDNA encoding human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD): a key enzyme for the tryptophan-niacine pathway and quinolinate hypothesis.
    Advances in experimental medicine and biology, 2003, Volume: 527

    Topics: Amino Acid Sequence; Animals; Base Sequence; Carboxy-Lyases; Cloning, Molecular; COS Cells; DNA, Complementary; Gene Expression; Humans; Models, Biological; Molecular Sequence Data; Niacin; Quinolinic Acid; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection; Tryptophan

2003
Phthalate esters enhance quinolinate production by inhibiting alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD), a key enzyme of the tryptophan pathway.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 81, Issue:2

    Topics: Animals; Body Weight; Carboxy-Lyases; Chromatography, High Pressure Liquid; Diet; Diethylhexyl Phthalate; Eating; Enzyme Inhibitors; Esters; Humans; Liver; Mice; Mice, Inbred ICR; Organ Size; Phthalic Acids; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan

2004
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
    Molecular and cellular biology, 2004, Volume: 24, Issue:16

    Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neurons; Phenotype; Pregnancy; Quinolinic Acid; Rats; Transaminases; Tryptophan

2004
Quinolinic acid metabolism; urinary excretion by the rat following tryptophan and 3-hydroxyanthranilic acid administration.
    The Journal of biological chemistry, 1949, Volume: 181, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Animals; Body Fluids; Quinolines; Quinolinic Acid; Rats; Tryptophan; Urine

1949
Quinolinic acid metabolism, urinary excretion by man and other mammals as affected by the ingestion of tryptophan.
    The Journal of biological chemistry, 1949, Volume: 181, Issue:2

    Topics: Animals; Eating; Humans; Male; Mammals; Quinolines; Quinolinic Acid; Tryptophan

1949
Differential effects of dietary fatty acids on rat liver alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase activity and gene expression.
    Biochimica et biophysica acta, 2004, Nov-08, Volume: 1686, Issue:1-2

    Topics: Animals; Body Weight; Carboxy-Lyases; Dietary Fats; Eating; Energy Intake; Gene Expression; Linoleic Acid; Liver; Male; Organ Size; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stearic Acids; Time Factors; Tryptophan

2004
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
    Neuroscience letters, 2005, Oct-21, Volume: 387, Issue:2

    Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Quinolinic Acid; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured; Up-Regulation

2005
Is the L-tryptophan metabolite quinolinic acid responsible for eosinophilic fasciitis?
    Clinical and experimental medicine, 2006, Volume: 6, Issue:2

    Topics: Eosinophilia; Fasciitis; Humans; Immunohistochemistry; In Vitro Techniques; Quinolinic Acid; Tryptophan

2006
Crystal structure and mechanism of tryptophan 2,3-dioxygenase, a heme enzyme involved in tryptophan catabolism and in quinolinate biosynthesis.
    Biochemistry, 2007, Jan-09, Volume: 46, Issue:1

    Topics: Binding Sites; Crystallography, X-Ray; Glycine; Heme; Indoleamine-Pyrrole 2,3,-Dioxygenase; Models, Molecular; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Folding; Quinolinic Acid; Ralstonia; Structure-Activity Relationship; Substrate Specificity; Tryptophan; Tryptophan Oxygenase

2007
Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism.
    The FEBS journal, 2007, Volume: 274, Issue:3

    Topics: Amino Acid Sequence; Brain; Carboxy-Lyases; Electrophoresis, Polyacrylamide Gel; Gene Expression Profiling; Humans; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Isoenzymes; Kidney; Kinetics; Liver; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Structure, Secondary; Quinolinic Acid; Recombinant Proteins; Sequence Alignment; Tryptophan

2007
Dietary protein level and dietary interaction affect quinolinic acid concentration in rats.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2007, Volume: 77, Issue:2

    Topics: Analysis of Variance; Animals; Body Weight; Carboxy-Lyases; Caseins; Diet; Dietary Proteins; Dose-Response Relationship, Drug; Fatty Acids; Kidney; Linoleic Acid; Liver; Male; Organ Size; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stearic Acids; Tryptophan

2007
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
    Neuro endocrinology letters, 2007, Volume: 28, Issue:6

    Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates

2007
Quinolinic acid excretion by the rat receiving tryptophan.
    The Journal of biological chemistry, 1949, Volume: 178, Issue:2

    Topics: Animals; Quinolinic Acid; Quinolinic Acids; Rats; Tryptophan; Urine

1949
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
    Epilepsia, 2008, Volume: 49 Suppl 2

    Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Disease Models, Animal; Electroencephalography; Encephalitis, Viral; Hippocampus; Kynurenine; Measles virus; Mice; Mice, Inbred BALB C; Microglia; Monitoring, Physiologic; Nerve Degeneration; Neuroglia; Pyramidal Cells; Quinolinic Acid; Seizures; Tryptophan

2008
Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2007, Volume: 77, Issue:4

    Topics: 3-Hydroxyanthranilic Acid; Adult; Chromatography, High Pressure Liquid; Feedback, Physiological; Female; Humans; Kynurenic Acid; Niacinamide; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates

2007
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia

2009
Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
    European journal of nutrition, 2009, Volume: 48, Issue:3

    Topics: Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Hepatocytes; Kynurenine; Male; Niacinamide; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tritium; Tryptophan; Water

2009
[Effects of excess nicotinic acid on growth and the urinary excretion of B-group vitamins and the metabolism of tryptophan in weaning rats].
    Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 2009, Volume: 50, Issue:2

    Topics: Animals; Eating; Growth; Male; Niacin; Quinolinic Acid; Rats; Rats, Wistar; Reference Values; Serotonin; Tryptophan; Vitamin B Complex; Weight Gain

2009
[Tryptophan and its metabolites in renal allograft recipients].
    Przeglad lekarski, 2009, Volume: 66, Issue:3

    Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Quinolinic Acid; Reference Values; Tryptophan; Urea

2009
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
    Thrombosis research, 2010, Volume: 125, Issue:2

    Topics: Adult; Antifibrinolytic Agents; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Fibrinolysin; Hemostasis; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Peptide Fragments; Peritoneal Dialysis, Continuous Ambulatory; Plasminogen Activator Inhibitor 1; Poland; Prevalence; Prothrombin; Quinolinic Acid; Receptors, Urokinase Plasminogen Activator; Thromboplastin; Tryptophan; Urokinase-Type Plasminogen Activator

2010
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
    Molecular psychiatry, 2010, Volume: 15, Issue:4

    Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis C; Humans; Interferon-alpha; Kynurenine; Longitudinal Studies; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type II; Ribavirin; Statistics as Topic; Tryptophan

2010
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
    Neurotoxicity research, 2010, Volume: 18, Issue:2

    Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Quinolinic Acid; Signal Transduction; Spinal Cord; Tryptophan

2010
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
    Central nervous system agents in medicinal chemistry, 2009, Volume: 9, Issue:1

    Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan

2009
Kynurenine and its metabolites in Alzheimer's disease patients.
    Advances in medical sciences, 2010, Volume: 55, Issue:2

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2010
Human myeloid dendritic cells are refractory to tryptophan metabolites.
    Human immunology, 2011, Volume: 72, Issue:10

    Topics: Antibodies; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Dendritic Cells; Flow Cytometry; Humans; Immunity, Cellular; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Macrophages; Membrane Glycoproteins; Monocytes; Quinolinic Acid; Receptors, Cell Surface; Receptors, Immunologic; T-Lymphocytes, Regulatory; Tryptophan

2011
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Journal of neuroinflammation, 2011, Aug-10, Volume: 8

    Topics: Adult; Aged; Depressive Disorder, Major; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Microglia; Middle Aged; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptophan

2011
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
    The FEBS journal, 2011, Volume: 278, Issue:22

    Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Liver; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Signal Transduction; Transaminases; Tryptophan; Tryptophan Oxygenase

2011
Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase.
    Blood, 2011, Dec-22, Volume: 118, Issue:26

    Topics: Adolescent; Adult; Aged; Chromatography, Liquid; Gene Expression Regulation, Enzymologic; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Intestines; Kynurenine; Mass Spectrometry; Middle Aged; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Time Factors; Transplantation, Homologous; Tryptophan; Young Adult

2011
Essential role of excessive tryptophan and its neurometabolites in fatigue.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2012, Volume: 39, Issue:1

    Topics: Acetylglucosaminidase; Amino Acids, Branched-Chain; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Exercise Test; Exploratory Behavior; Fatigue; Female; Fluoxetine; Hydroxyindoleacetic Acid; Kynurenic Acid; Locomotion; Maze Learning; Microdialysis; Quinolinic Acid; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereotyped Behavior; Synaptosomes; Time Factors; Tryptophan

2012
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.
    Neuropharmacology, 2012, Volume: 62, Issue:8

    Topics: Animals; Antipsychotic Agents; Clozapine; Kynurenine; Male; ortho-Aminobenzoates; Oxidative Stress; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Social Isolation; Tryptophan

2012
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2012, Jun-01, Volume: 898

    Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan

2012
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
    European archives of psychiatry and clinical neuroscience, 2013, Volume: 263, Issue:4

    Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan

2013
Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.
    Bioscience, biotechnology, and biochemistry, 2013, Volume: 77, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Food, Formulated; Liver; Male; Niacinamide; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Valproic Acid

2013
The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
    Cancer research, 2013, Jun-01, Volume: 73, Issue:11

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Microglia; NAD; Oxidative Stress; Pentosyltransferases; Quinolinic Acid; Temozolomide; Tryptophan; Tryptophan Oxygenase

2013
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
    The Journal of nutrition, 2013, Volume: 143, Issue:7

    Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates

2013
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
    Journal of neurochemistry, 2013, Volume: 127, Issue:6

    Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan; Tryptophan Oxygenase

2013
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
    Thorax, 2013, Volume: 68, Issue:12

    Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokines; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Nitric Oxide; ortho-Aminobenzoates; Peroxidase; Picornaviridae Infections; Prospective Studies; Quinolinic Acid; Rhinovirus; Tryptophan; Young Adult

2013
The ACMSD gene, involved in tryptophan metabolism, is mutated in a family with cortical myoclonus, epilepsy, and parkinsonism.
    Journal of molecular medicine (Berlin, Germany), 2013, Volume: 91, Issue:12

    Topics: Adult; Aged; Amino Acid Sequence; Brain; Carboxy-Lyases; DNA Mutational Analysis; Electroencephalography; Epilepsies, Myoclonic; Exome; Female; High-Throughput Nucleotide Sequencing; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Sequence Data; Mutation; Neuropsychological Tests; Pedigree; Quinolinic Acid; Sequence Alignment; Tryptophan; Young Adult

2013
Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
    Bioscience, biotechnology, and biochemistry, 2013, Volume: 77, Issue:10

    Topics: Animals; Body Weight; Eating; Enzymes; Male; Mice; NAD; Niacinamide; Pyridones; Quinolinic Acid; Tryptophan

2013
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
    Schizophrenia research, 2014, Volume: 152, Issue:1

    Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan

2014
Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry.
    Journal of mass spectrometry : JMS, 2014, Volume: 49, Issue:2

    Topics: Adult; Animals; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kynurenine; Linear Models; Male; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reproducibility of Results; Serotonin; Tryptophan; Young Adult

2014
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
    Brain, behavior, and immunity, 2014, Volume: 41

    Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan

2014
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:2

    Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan

2015
Involvement of the kynurenine pathway in human glioma pathophysiology.
    PloS one, 2014, Volume: 9, Issue:11

    Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Biosynthetic Pathways; Brain Neoplasms; Carboxy-Lyases; CD11b Antigen; Cells, Cultured; Chromatography, High Pressure Liquid; Disaccharides; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Glucuronates; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured

2014
Large amounts of picolinic acid are lethal but small amounts increase the conversion of tryptophan-nicotinamide in rats.
    Journal of nutritional science and vitaminology, 2014, Volume: 60, Issue:5

    Topics: Animals; Body Weight; Carboxy-Lyases; Dose-Response Relationship, Drug; Iron Chelating Agents; Kynurenic Acid; Liver; Male; Niacinamide; ortho-Aminobenzoates; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Xanthurenates

2014
Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers.
    Psychoneuroendocrinology, 2015, Volume: 56

    Topics: Adolescent; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Interview, Psychological; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Signal Transduction; Treatment Outcome; Tryptophan; Young Adult

2015
Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
    Journal of neurovirology, 2015, Volume: 21, Issue:4

    Topics: Animals; Anti-Retroviral Agents; Brain; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Kynurenine; Macaca; Polymerase Chain Reaction; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Tryptophan

2015
Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.
    G3 (Bethesda, Md.), 2015, May-04, Volume: 5, Issue:7

    Topics: Amino Acid Transport Systems; Bleomycin; DNA Damage; DNA Repair; Galactose; Mechanistic Target of Rapamycin Complex 1; Membrane Proteins; Multiprotein Complexes; NAD; Quinolinic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Telomere; TOR Serine-Threonine Kinases; Tryptophan

2015
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.
    Journal of neuroscience research, 2015, Volume: 93, Issue:9

    Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Kynurenic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurotoxicity Syndromes; Oxidative Stress; Quinolinic Acid; Receptors, Aryl Hydrocarbon; Tryptophan

2015
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
    Journal of neuroinflammation, 2015, May-30, Volume: 12

    Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Case-Control Studies; Female; Glasgow Outcome Scale; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neurotoxins; Prognosis; Quinolinic Acid; RNA, Messenger; Signal Transduction; Tryptophan; Young Adult

2015
Interferon-alpha treatment induces depression-like behaviour accompanied by elevated hippocampal quinolinic acid levels in rats.
    Behavioural brain research, 2015, Oct-15, Volume: 293

    Topics: Animals; Antidepressive Agents; Chromatography, Liquid; Depression; Dose-Response Relationship, Drug; Electrochemistry; Food Preferences; Hippocampus; Illness Behavior; Interferon-alpha; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Saccharin; Statistics, Nonparametric; Sweetening Agents; Swimming; Tryptophan

2015
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
    BMC infectious diseases, 2015, Aug-19, Volume: 15

    Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Cross-Sectional Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gas Chromatography-Mass Spectrometry; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-6; Kynurenine; Male; Middle Aged; Neopterin; Niacinamide; Pentosyltransferases; Poverty; Quinolinic Acid; South Africa; Tryptophan

2015
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
    Brain, behavior, and immunity, 2016, Volume: 53

    Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan

2016
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay.
    Journal of complementary & integrative medicine, 2016, Jun-01, Volume: 13, Issue:2

    Topics: Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Growth Inhibitors; Humans; Interferon-gamma; Interleukin-6; Kynurenine; Melatonin; Milk, Human; Neuroglia; ortho-Aminobenzoates; Oxygen Radical Absorbance Capacity; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates

2016
Central kynurenine pathway shift with age in women.
    Journal of neurochemistry, 2016, Volume: 136, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult

2016
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
    The journal of headache and pain, 2015, Volume: 17

    Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates

2015
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
    The journal of headache and pain, 2015, Volume: 17

    Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates

2015
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
    Neuroscience, 2016, 08-04, Volume: 329

    Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan

2016
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
    Psychoneuroendocrinology, 2016, Volume: 71

    Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan

2016
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Adult; Bariatric Surgery; C-Reactive Protein; Diabetes Mellitus; Female; Glucose; Homeostasis; Humans; Kynurenine; Metabolome; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates

2016
LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
    Bioanalysis, 2016, Volume: 8, Issue:18

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Humans; Kynurenine; Mice, Inbred C57BL; Neopterin; ortho-Aminobenzoates; Quinolinic Acid; Signal Transduction; Tandem Mass Spectrometry; Tryptophan

2016
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
    Scandinavian journal of immunology, 2016, Volume: 84, Issue:5

    Topics: Flagellin; Gene Expression Regulation; Humans; Hydrolysis; Imidazoles; Kynurenic Acid; Kynurenine; Lipopeptides; Lipopolysaccharides; Listeria monocytogenes; Monocytes; Poly I-C; Primary Cell Culture; Protein Isoforms; Quinolinic Acid; Signal Transduction; Toll-Like Receptors; Tryptophan

2016
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity.
    Psychiatry research, 2017, Volume: 247

    Topics: Bipolar Disorder; Female; Humans; Interleukin-6; Interleukin-8; Kynurenic Acid; Male; Middle Aged; Personality; Psychotic Disorders; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Tumor Necrosis Factor-alpha; Twins

2017
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
    Molecular autism, 2016, Volume: 7

    Topics: Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Coenzyme A; Dysbiosis; Female; Humans; Hydrophobic and Hydrophilic Interactions; Indoleacetic Acids; Italy; Kynurenic Acid; Male; Melatonin; Metabolomics; Pantothenic Acid; Purines; Pyrimidines; Quinolinic Acid; Riboflavin; Tryptophan; Vitamin B 6; Xanthurenates

2016
n-Butylidenephthalide exhibits protection against neurotoxicity through regulation of tryptophan 2, 3 dioxygenase in spinocerebellar ataxia type 3.
    Neuropharmacology, 2017, 05-01, Volume: 117

    Topics: Animals; Ataxin-3; Calcium; Calpain; Cerebellum; Disease Models, Animal; HEK293 Cells; Humans; Machado-Joseph Disease; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Neuroprotective Agents; Phthalic Anhydrides; Quinolinic Acid; Ryanodine Receptor Calcium Release Channel; Tryptophan; Tryptophan Oxygenase

2017
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan

2017
Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.
    Molecular neurobiology, 2018, Volume: 55, Issue:3

    Topics: Adult; Biomarkers; Female; Humans; Immunity, Cellular; Immunoglobulin M; Kynurenic Acid; Male; Metabolism; Middle Aged; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Signal Transduction; Tryptophan; Xanthurenates

2018
Maternal Inflammation Results in Altered Tryptophan Metabolism in Rabbit Placenta and Fetal Brain.
    Developmental neuroscience, 2017, Volume: 39, Issue:5

    Topics: Animals; Brain; Female; Indoles; Inflammation; Placenta; Pregnancy; Quinolinic Acid; Rabbits; Serotonin; Tryptophan

2017
Uridine monophosphate synthetase enables eukaryotic
    The Journal of biological chemistry, 2017, 07-07, Volume: 292, Issue:27

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Multienzyme Complexes; Mutation; NAD; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Quinolinic Acid; Tryptophan

2017
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
    Modern trends in pharmacopsychiatry, 2017, Volume: 31

    Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative Stress; Quinolinic Acid; Tryptophan

2017
Increased Tryptophan Metabolism Is Associated With Activity of Inflammatory Bowel Diseases.
    Gastroenterology, 2017, Volume: 153, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Transport Systems, Neutral; Biomarkers; Biotransformation; C-Reactive Protein; Case-Control Studies; Colitis, Ulcerative; Colon; Crohn Disease; Feces; Female; Gastrointestinal Microbiome; Germany; Humans; Inflammation Mediators; Interleukin-22; Interleukins; Male; Middle Aged; Predictive Value of Tests; Prognosis; Prospective Studies; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase; Young Adult

2017
Kynurenine Pathway Metabolites in Alzheimer's Disease.
    Journal of Alzheimer's disease : JAD, 2017, Volume: 60, Issue:2

    Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Female; Humans; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Signal Transduction; Statistics, Nonparametric; Tryptophan; Xanthurenates

2017
Effects of high ambient temperature on plasma metabolomic profiles in chicks.
    Animal science journal = Nihon chikusan Gakkaiho, 2018, Volume: 89, Issue:2

    Topics: Amino Acids, Sulfur; Animals; Chickens; Cystathionine; Cysteine; Cystine; Environmental Exposure; Gas Chromatography-Mass Spectrometry; Homocysteine; Hot Temperature; Kynurenine; Molecular Weight; Niacinamide; Oxidative Stress; Quinolinic Acid; Taurine; Tryptophan

2018
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
    Journal of ethnopharmacology, 2018, Mar-25, Volume: 214

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Locomotion; Male; Neural Cell Adhesion Molecules; Quinolinic Acid; Rats, Sprague-Dawley; Signal Transduction; Tryptophan

2018
A validated liquid chromatography-high resolution-tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma.
    Electrophoresis, 2018, Volume: 39, Issue:9-10

    Topics: Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Kynurenic Acid; Kynurenine; Limit of Detection; Metabolome; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan

2018
Kynurenine Pathway in Autism Spectrum Disorders in Children.
    Neuropsychobiology, 2017, Volume: 76, Issue:2

    Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan

2017
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
    Molecular neurobiology, 2019, Volume: 56, Issue:1

    Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan

2019
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.
    Psychoneuroendocrinology, 2018, Volume: 95

    Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan

2018
The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:6

    Topics: Adolescent; Adult; Aged; Analysis of Variance; Cognition Disorders; Executive Function; Female; Humans; Immunoglobulin A; Immunoglobulin M; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Neuropsychological Tests; Picolinic Acids; Psychiatric Status Rating Scales; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Xanthurenates; Young Adult

2018
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
    CNS & neurological disorders drug targets, 2018, Volume: 17, Issue:8

    Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Child; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan

2018
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
    Medical hypotheses, 2018, Volume: 118

    Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan

2018
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
    Journal of translational medicine, 2018, 08-06, Volume: 16, Issue:1

    Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Lung Neoplasms; Male; Multivariate Analysis; Programmed Cell Death 1 Receptor; Quinolinic Acid; Tryptophan

2018
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
    Psychoneuroendocrinology, 2019, Volume: 101

    Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan

2019
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age.
    Oxidative medicine and cellular longevity, 2018, Volume: 2018

    Topics: Aged; Aged, 80 and over; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Quinolinic Acid; Tryptophan

2018
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
    Schizophrenia research, 2019, Volume: 208

    Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult

2019
Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
    Journal of pharmaceutical and biomedical analysis, 2019, Jun-05, Volume: 170

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenine; Male; Neurotransmitter Agents; Plasma; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tandem Mass Spectrometry; Toxoplasmosis; Tryptophan

2019
Effect of quinolinic acid - A uremic toxin from tryptophan metabolism - On hemostatic profile in rat and mouse thrombosis models.
    Advances in medical sciences, 2019, Volume: 64, Issue:2

    Topics: Animals; Fibrinolysis; Hemostasis; Male; Mice; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Thrombosis; Tryptophan

2019
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.
    European archives of psychiatry and clinical neuroscience, 2020, Volume: 270, Issue:7

    Topics: Adult; Aged; Bipolar Disorder; Chemokine CCL2; Cohort Studies; Female; Humans; Kynurenic Acid; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Sweden; Tryptophan

2020
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
    The Journal of infectious diseases, 2020, 01-14, Volume: 221, Issue:3

    Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio

2020
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
    Brain, behavior, and immunity, 2020, Volume: 83

    Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates

2020
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan

2020
A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis.
    Journal of pharmaceutical and biomedical analysis, 2020, Jun-05, Volume: 185

    Topics: Adult; Biomarkers; Calibration; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Picolinic Acids; Quinolinic Acid; Reference Standards; Tandem Mass Spectrometry; Tryptophan; Young Adult

2020
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
    Neurochemical research, 2020, Volume: 45, Issue:12

    Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oximes; Peptide Fragments; Quinolinic Acid; Sulfonamides; Tryptophan

2020
Formation of amino acid derivatives in white and red wines during fermentation: Effects of non-Saccharomyces yeasts and Oenococcus oeni.
    Food chemistry, 2021, May-01, Volume: 343

    Topics: Amino Acids; Fermentation; Food Microbiology; Oenococcus; Picolinic Acids; Quinolinic Acid; Saccharomyces cerevisiae; Saccharomycetales; Torulaspora; Tryptophan; Wine

2021
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
    Journal of acquired immune deficiency syndromes (1999), 2021, 06-01, Volume: 87, Issue:2

    Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Psychometrics; Quinolinic Acid; Tryptophan

2021
Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.
    Translational psychiatry, 2021, 04-01, Volume: 11, Issue:1

    Topics: Humans; Kynurenic Acid; Kynurenine; Memory, Short-Term; Quinolinic Acid; Schizophrenia; Tryptophan

2021
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.
    Scientific reports, 2021, 05-11, Volume: 11, Issue:1

    Topics: Adult; Case-Control Studies; Cognition; Cognitive Dysfunction; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Tryptophan; Young Adult

2021
Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes.
    PloS one, 2021, Volume: 16, Issue:7

    Topics: Adolescent; Child; Chromatography, Liquid; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Glucose; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan

2021
Does the type of exercise affect tryptophan catabolism in horses?
    Animal : an international journal of animal bioscience, 2021, Volume: 15, Issue:11

    Topics: Animals; Chromatography, High Pressure Liquid; Horses; Kynurenic Acid; Quinolinic Acid; Tryptophan

2021
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    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2021, Volume: 26, Issue:8

    Topics: Biomarkers; Depressive Disorder, Major; Heart Rate; Humans; Kynurenine; Quinolinic Acid; Reproducibility of Results; Sensitivity and Specificity; Stress, Physiological; Tryptophan

2021
Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus.
    Lupus science & medicine, 2021, Volume: 8, Issue:1

    Topics: Cognitive Dysfunction; Cross-Sectional Studies; Humans; Kynurenine; Lupus Erythematosus, Systemic; Neuropsychological Tests; Quinolinic Acid; Tryptophan

2021
Cell stress response impairs de novo NAD+ biosynthesis in the kidney.
    JCI insight, 2022, 01-11, Volume: 7, Issue:1

    Topics: Acute Kidney Injury; Animals; Cell Line; Endoplasmic Reticulum Stress; Kidney; Male; Mice; Mice, Inbred C57BL; NAD; Pentosyltransferases; Quinolinic Acid; Tryptophan

2022
Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
    The Journal of pathology, 2022, Volume: 256, Issue:3

    Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Apoptosis; Autopsy; Brain; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung; Middle Aged; Myocardium; Prospective Studies; Quinolinic Acid; Severity of Illness Index; Tryptophan

2022
Alterations in Kynurenine and NAD
    International journal of molecular sciences, 2021, Dec-16, Volume: 22, Issue:24

    Topics: Colitis; Humans; Inflammatory Bowel Diseases; Infliximab; Kynurenine; Metabolic Networks and Pathways; Nicotinamide N-Methyltransferase; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, Nicotinic; Tryptophan

2021
Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
    Journal of clinical laboratory analysis, 2022, Volume: 36, Issue:3

    Topics: Adult; Aged; COVID-19; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Picolinic Acids; Prognosis; Quinolinic Acid; SARS-CoV-2; Tryptophan

2022
Quinolinic Acid, a Tryptophan Metabolite of the Skin Microbiota, Negatively Regulates NLRP3 Inflammasome through AhR in Psoriasis.
    The Journal of investigative dermatology, 2022, Volume: 142, Issue:8

    Topics: Animals; Humans; Inflammasomes; Mice; Microbiota; NLR Family, Pyrin Domain-Containing 3 Protein; Psoriasis; Quinolinic Acid; Receptors, Aryl Hydrocarbon; Skin; Tryptophan

2022
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
    Clinical oral investigations, 2022, Volume: 26, Issue:9

    Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
    Amino acids, 2022, Volume: 54, Issue:6

    Topics: Behcet Syndrome; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan

2022
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Cross-Sectional Studies; Female; Humans; Kynurenic Acid; Kynurenine; Polycystic Ovary Syndrome; Quinolinic Acid; Serotonin; Tryptophan

2022
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
    Alcoholism, clinical and experimental research, 2022, Volume: 46, Issue:9

    Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Neopterin; Quinolinic Acid; Substance Withdrawal Syndrome; Tryptophan

2022
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.
    Scientific reports, 2022, 09-16, Volume: 12, Issue:1

    Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Lymnaea; Quinolinic Acid; Tryptophan

2022
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
    EBioMedicine, 2022, Volume: 84

    Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan

2022
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan

2022
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
    Journal of psychosomatic research, 2022, Volume: 163

    Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan

2022
Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE.
    Lupus science & medicine, 2022, Volume: 9, Issue:1

    Topics: Cognitive Dysfunction; Humans; Interferons; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Quinolinic Acid; Tryptophan

2022
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
    Kardiologiia, 2022, Nov-30, Volume: 62, Issue:11

    Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic Acid; Kynurenine; Quinolinic Acid; Serotonin; Tryptophan

2022
Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis.
    Nature communications, 2023, 03-16, Volume: 14, Issue:1

    Topics: Animals; Biological Products; Brain Neoplasms; Glioblastoma; Immune Tolerance; Macrophages; Mice; Neurodegenerative Diseases; PPAR gamma; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Tryptophan; Tumor Microenvironment

2023
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
    EBioMedicine, 2023, Volume: 91

    Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocytosis; Male; Neopterin; Nervous System Diseases; Neuroinflammatory Diseases; Quinolinic Acid; Tryptophan

2023
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.
    Microbiome, 2023, 06-30, Volume: 11, Issue:1

    Topics: Adolescent; Animals; Coleoptera; Depression; Gastrointestinal Microbiome; Humans; Kynurenine; Metabolomics; Mice; Microbiota; Quinolinic Acid; Serotonin; Sertraline; Tryptophan

2023
Relationship of tryptophan metabolites with the type and severity of multiple sclerosis.
    Multiple sclerosis and related disorders, 2023, Volume: 77

    Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Mammals; Multiple Sclerosis; Quinolinic Acid; Tryptophan

2023
Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
    Kidney international, 2023, Volume: 104, Issue:6

    Topics: Acute Kidney Injury; Animals; Hepatocyte Nuclear Factors; Kidney; Mice; NAD; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Quinolinic Acid; Tryptophan

2023
The possible role of quinolinic acid as a predictive marker in patients with SARS-CoV-2.
    Clinica chimica acta; international journal of clinical chemistry, 2023, Oct-01, Volume: 550

    Topics: C-Reactive Protein; COVID-19; Humans; Kynurenine; Procalcitonin; Quinolinic Acid; SARS-CoV-2; Tryptophan

2023