quinolinic acid and nad

quinolinic acid has been researched along with nad in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-19908 (13.33)18.7374
1990's10 (16.67)18.2507
2000's19 (31.67)29.6817
2010's18 (30.00)24.3611
2020's5 (8.33)2.80

Authors

AuthorsStudies
Pewnim, T; Seifert, J1
Hayakawa, T; Iwai, K; Shibata, K; Taguchi, H1
Fridovich, I; Gardner, PR1
Kiyohara, Y; Sano, K; Shin, M; Shirasawa, K; Umezawa, C1
Flachmann, R; Gassen, HG; Gütlich, M; Kunz, N; Läufer, A; Seifert, J; Wientjes, FJ1
Hayakawa, T; Iwai, K; Murata, K; Shibata, K1
Brougher, DS; Foster, AC; Okuno, E; Schwarcz, R1
Dousa, TP; Kempson, SA; Ou, SY1
Filov, VA; Ivin, BA; Kon'kov, SA; Krylova, IM; Reztsova, VV1
Cheng, W; Roth, JR1
Grant, RS; Kapoor, V1
Blinder, KL; Moffett, JR; Namboodiri, MA; Venkateshan, CN1
Brown, OR; Dang, Y; Xia, C1
Amici, A; Emanuelli, M; Magni, G; Raffaelli, N; Ruggieri, S1
Grant, RS; Kapoor, V; Matanovic, G; Passey, R; Smythe, G1
Brown, OR; Dale, WE; Dang, Y1
Cleaves, HJ; Miller, SL1
Fukuwatari, T; Shibata, K; Sugimoto, E1
Sanni, LA1
Fukuwatari, T; Hayakawa, F; Morikawa, Y; Shibata, K; Sugimoto, E1
Fukuwatari, T; Morikawa, Y; Shibata, K; Sugimoto, E1
Moffett, JR; Namboodiri, MA1
AURICCHIO, S; QUAGLIARIELLO, E; RINALDI, E; VIOLANTE, A1
ANDREOLI, AJ; HAYAISHI, O; IKEDA, M; NISHIZUKA, Y1
GHOLSON, RK; HENDERSON, LM; OGASAWARA, N; UEDA, I1
Gerlt, JA1
Anantha, S; Begley, TP; Colabroy, K; Gerdes, S; Goral, V; Kurnasov, O; Osterman, A1
Fukuwatari, T; Sasaki, R; Shibata, K; Wada, H1
Begley, TP; Colabroy, KL1
Akita, M; Hashimoto, T; Katoh, A; Uenohara, K1
Gakière, B; Noctor, G; Queval, G1
Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N1
Lee, JK; Rozenberg, A1
Ashihara, H; Matsui, A; Sakuta, M; Yin, Y1
Fülöp, F; Klivényi, P; Toldi, J; Vámos, E; Vécsei, L; Zádori, D1
Ashihara, H; Katahira, R1
Galeazzi, L; Garavaglia, S; Perozzi, S; Raffaelli, N; Rizzi, M1
Adams, S; Braidy, N; Grant, R; Guillemin, GJ1
Gakière, B; Guérard, F; Pétriacq, P; Tcherkez, G1
de Bont, L; Didierlaurent, L; Gakière, B; Guérard, F; Hager, J; Mauve, C; Noctor, G; Pelletier, S; Pétriacq, P; Renou, JP; Tcherkez, G1
Fukuoka, S; Fukuwatari, T; Nakao, N; Sano, M; Sasaki, R; Shibata, K; Terakata, M1
Blaby, IK; de Crécy-Lagard, V; De Ingeniis, J; Osterman, AL; Rodionova, IA; Sorci, L; Tkachenko, S1
Kawai, S; Murata, K; Ohashi, K1
Adams, S; Ahrendt, T; Bode, HB; Guillemin, GJ; Oezen, I; Opitz, CA; Platten, M; Radlwimmer, B; Sahm, F; von Deimling, A; Wick, W1
Fukuwatari, T; Morita, N; Shibata, K; Shibata, Y1
Kumar, A; Mishra, J1
Bertuch, AA; Polleys, EJ1
Couté, Y; Ollagnier de Choudens, S; Reichmann, D1
Shibata, K1
Muramoto, K; Nakagawa, S; Ogawa, T; Shigeoka, S; Takada, R; Yoshimura, K1
Armstrong, SK; Brickman, TJ; McKelvey, PJ; Suhadolc, RJ1
Hanna-Rose, W; Holleran, LM; McReynolds, MR; Wang, W1
Amara, P; Darnault, C; Fontecilla-Camps, JC; Gigarel, O; Hamelin, O; Han, TH; Ollagnier-de-Choudens, S; Renoux, O; Saez Cabodevilla, J; Volbeda, A1
Adams, S; Castellano-Gonzalez, G; Cole, NJ; Don, E; Guillemin, GJ; Jacobs, KR; Lim, CK; Lovejoy, DB1
Cater, T; Croft, T; Dhugga, G; Groth, B; James Theoga Raj, C; Lin, SJ; Venkatakrishnan, P1
Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R1
Hanasaki, M; Masumoto, H; Nakagawa, T; Yaku, K; Yamauchi, M1
Chen, Y; Ding, Y; Horsman, GP; Li, J; Li, P; Li, X; Liu, W; Tao, Y; Wang, M; Wu, B; Zhang, Z1
Anglicheau, D; Bignon, Y; Cippà, PE; Fohlen, B; Galichon, P; Hertig, A; Karras, A; Lenoir, O; Nadour, Z; Naesens, M; Nemazanyy, I; Pallet, N; Poindessous, V; Rinaldi, A; Weill-Raynal, P1
Ciampa, EJ; Clark, AJ; Etzrodt, V; Flores, BM; Huang, H; Parikh, SM; Saade, MC; Takakura, A; Vemireddy, V; Vu, KQ; Zandi-Nejad, K; Zsengellér, ZK1

Reviews

5 review(s) available for quinolinic acid and nad

ArticleYear
Enzymology of NAD+ synthesis.
    Advances in enzymology and related areas of molecular biology, 1999, Volume: 73

    Topics: Amide Synthases; Amidohydrolases; Animals; Humans; NAD; Niacin; Nicotinamidase; Nicotinamide-Nucleotide Adenylyltransferase; Pentosyltransferases; Phosphotransferases (Alcohol Group Acceptor); Pyrophosphatases; Quinolinic Acid

1999
Tryptophan and the immune response.
    Immunology and cell biology, 2003, Volume: 81, Issue:4

    Topics: Animals; Dendritic Cells; Dioxygenases; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxygenases; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

2003
NAD(P) synthesis and pyridine nucleotide cycling in plants and their potential importance in stress conditions.
    Journal of experimental botany, 2006, Volume: 57, Issue:8

    Topics: Amino Acid Sequence; Cell Compartmentation; Molecular Sequence Data; NAD; NADP; Nicotinamide Mononucleotide; Oxidation-Reduction; Plants; Quinolinic Acid; Sequence Homology, Amino Acid

2006
Tryptophan, adenosine, neurodegeneration and neuroprotection.
    Metabolic brain disease, 2007, Volume: 22, Issue:3-4

    Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Tryptophan

2007
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:11

    Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenic Acid; Mitochondrial Diseases; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolinic Acid; Tryptophan

2009

Other Studies

55 other study(ies) available for quinolinic acid and nad

ArticleYear
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
    Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11

    Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates

1992
Regulation of pyridine nucleotide coenzyme metabolism.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: Animals; Dietary Proteins; Liver; Male; NAD; Niacin; Nicotinamide Mononucleotide; Organ Specificity; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1991
Quinolinate phosphoribosyl transferase is not the oxygen-sensitive site of nicotinamide adenine dinucleotide biosynthesis.
    Free radical biology & medicine, 1990, Volume: 8, Issue:2

    Topics: Bacterial Proteins; Chromatography, Paper; Escherichia coli; Free Radicals; Hydrogen Peroxide; Hyperbaric Oxygenation; NAD; Niacin; Pentosyltransferases; Quinolinic Acid; Quinolinic Acids

1990
Tryptophan metabolism by the isolated rat liver cells--effects of leucine and its metabolites.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1989, Volume: 59, Issue:1

    Topics: Acetoacetates; Animals; In Vitro Techniques; Keto Acids; Leucine; Liver; NAD; Pentosyltransferases; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan

1989
Molecular biology of pyridine nucleotide biosynthesis in Escherichia coli. Cloning and characterization of quinolinate synthesis genes nadA and nadB.
    European journal of biochemistry, 1988, Aug-01, Volume: 175, Issue:2

    Topics: Amino Acid Oxidoreductases; Amino Acid Sequence; Bacterial Proteins; Base Sequence; Cloning, Molecular; DNA Restriction Enzymes; Escherichia coli; Escherichia coli Proteins; Genes; Genes, Bacterial; Molecular Sequence Data; NAD; Plasmids; Promoter Regions, Genetic; Pyridines; Quinolinic Acid; Quinolinic Acids

1988
Effect of dietary orotic acid on the levels of liver and blood NAD in rats.
    Journal of nutritional science and vitaminology, 1985, Volume: 31, Issue:3

    Topics: Animals; Body Weight; Creatinine; Diet; DNA; Fats; Liver; Male; NAD; Niacin; Organ Size; Orotic Acid; Proteins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Time Factors; Tryptophan

1985
A radioenzymatic assay for quinolinic acid.
    Analytical biochemistry, 1986, Volume: 158, Issue:1

    Topics: Adult; Humans; Male; NAD; Nicotinamide Mononucleotide; Pentosyltransferases; Pyridines; Quinolinic Acid; Quinolinic Acids; Tritium

1986
Relationship between rate of gluconeogenesis and content of nicotinamide adenine dinucleotide in renal cortex.
    Life sciences, 1981, Sep-21, Volume: 29, Issue:12

    Topics: Animals; Cytosol; Gluconeogenesis; Glutamates; Glutamic Acid; In Vitro Techniques; Ketoglutaric Acids; Kidney Cortex; Kinetics; Male; NAD; Picolinic Acids; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1981
[Basic and salvage pathways of NAD biosynthesis in organs of normal rats, tumor-bearing rats and in tumors].
    Voprosy onkologii, 1994, Volume: 40, Issue:1-3

    Topics: Animals; Carcinoma 256, Walker; Enzyme Precursors; Kidney; Liver; Lymphoma, Non-Hodgkin; NAD; Neoplasms, Experimental; Niacin; Niacinamide; Quinolinic Acid; Rats

1994
Evidence for two NAD kinases in Salmonella typhimurium.
    Journal of bacteriology, 1994, Volume: 176, Issue:14

    Topics: Chromosome Mapping; Chromosomes, Bacterial; Culture Media; Genes, Bacterial; Mutagenesis; NAD; NADP; Phosphotransferases (Alcohol Group Acceptor); Quinolinic Acid; Salmonella typhimurium; Temperature

1994
Murine glial cells regenerate NAD, after peroxide-induced depletion, using either nicotinic acid, nicotinamide, or quinolinic acid as substrates.
    Journal of neurochemistry, 1998, Volume: 70, Issue:4

    Topics: Animals; Hydrogen Peroxide; NAD; Neuroglia; Niacin; Niacinamide; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substrate Specificity

1998
Differential effects of kynurenine and tryptophan treatment on quinolinate immunoreactivity in rat lymphoid and non-lymphoid organs.
    Cell and tissue research, 1998, Volume: 293, Issue:3

    Topics: Animals; Immunohistochemistry; Injections, Intraperitoneal; Kynurenine; Lymphoid Tissue; Male; NAD; Organ Specificity; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

1998
HPLC analysis of quinolinic acid, a NAD biosynthesis intermediate, after fluorescence derivatization in an aqueous matrix.
    Microbios, 1998, Volume: 94, Issue:379

    Topics: Cadaverine; Chromatography, High Pressure Liquid; Fluorescent Dyes; NAD; Quinolinic Acid; Sensitivity and Specificity; Water

1998
Evidence for increased de novo synthesis of NAD in immune-activated RAW264.7 macrophages: a self-protective mechanism?
    Archives of biochemistry and biophysics, 1999, Dec-01, Volume: 372, Issue:1

    Topics: Animals; Benzamides; Cell Line; Dexamethasone; Enzyme Inhibitors; Interferon-gamma; Macrophage Activation; Macrophages; Mice; NAD; NG-Nitroarginine Methyl Ester; Niacinamide; Nitric Oxide Synthase; Poly(ADP-ribose) Polymerase Inhibitors; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tryptophan Oxygenase

1999
Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices.
    Free radical biology & medicine, 2000, Jul-15, Volume: 29, Issue:2

    Topics: Aerobiosis; Animals; Brain; In Vitro Techniques; Kynurenine; Liver; Male; NAD; Organ Specificity; Oxygen; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

2000
The nicotinamide biosynthetic pathway is a by-product of the RNA world.
    Journal of molecular evolution, 2001, Volume: 52, Issue:1

    Topics: Aspartic Acid; Dihydroxyacetone; Dihydroxyacetone Phosphate; Glyceraldehyde; Glyceraldehyde 3-Phosphate; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Molecular Structure; NAD; Niacin; Quinolinic Acid; RNA

2001
Effects of dietary pyrazinamide, an antituberculosis agent, on the metabolism of tryptophan to niacin and of tryptophan to serotonin in rats.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:6

    Topics: Animals; Antitubercular Agents; Diet; Eating; Liver; Male; NAD; NADP; Niacin; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tryptophan; Weight Gain

2001
The role of cerebral oedema in the pathogenesis of cerebral malaria.
    Redox report : communications in free radical research, 2001, Volume: 6, Issue:3

    Topics: Adult; Africa; Animals; Asia, Southeastern; Blood-Brain Barrier; Brain Edema; Cell Adhesion; Cerebrovascular Circulation; Child; Cytokines; Energy Metabolism; Humans; Hypoxia-Ischemia, Brain; Indoleamine-Pyrrole 2,3,-Dioxygenase; Malaria; Malaria, Cerebral; Malaria, Falciparum; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Models, Biological; NAD; Nerve Tissue Proteins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Plasmodium berghei; Quinolinic Acid; Tryptophan Oxygenase; Vasodilation

2001
Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats.
    Bioscience, biotechnology, and biochemistry, 2001, Volume: 65, Issue:10

    Topics: 3-Hydroxyanthranilic Acid; Adenine; Animals; Kidney; Kynurenic Acid; Liver; Male; NAD; Niacin; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Xanthurenates

2001
Effects of fatty liver induced by niacin-free diet with orotic acid on the metabolism of tryptophan to niacin in rats.
    Bioscience, biotechnology, and biochemistry, 2002, Volume: 66, Issue:6

    Topics: Animals; Diet; Fats; Fatty Liver; Feeding Behavior; Liver; Male; NAD; NADP; Niacin; Organ Size; Orotic Acid; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Vitamin B Deficiency; Weight Gain

2002
On the effect of DPN on the conversion of 3-hydroxyanthranilic acid to quinolinic acid in presence of hepatic tissue of rats affected by Oberling's myeloma in the leukemic phase.
    Clinica chimica acta; international journal of clinical chemistry, 1958, Volume: 3, Issue:5

    Topics: 3-Hydroxyanthranilic Acid; Animals; Coenzymes; Leukemia; Leukemia, Myeloid; Liver; Multiple Myeloma; NAD; Pyridines; Quinolinic Acid; Rats

1958
Quinolinic acid: a precursor to nicotinamide adenine dinucleotide in Escherichia coli.
    Biochemical and biophysical research communications, 1963, Jul-18, Volume: 12

    Topics: Escherichia coli; Humans; NAD; Pyridines; Quinolinic Acid

1963
THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER.
    The Journal of biological chemistry, 1964, Volume: 239

    Topics: Aniline Compounds; Animals; Carbon Isotopes; Cattle; Chromatography; Glycerol; Lactobacillus; Liver; Liver Extracts; Magnesium; Manganese; Metabolism; NAD; Niacin; Nicotinamide Mononucleotide; Nicotinic Acids; Pyridines; Quinolinic Acid; Research

1964
How to find "missing" genes.
    Chemistry & biology, 2003, Volume: 10, Issue:12

    Topics: Bacteria; Bacterial Proteins; Genes, Bacterial; Genome, Bacterial; Genomics; Molecular Structure; NAD; Quinolinic Acid

2003
NAD biosynthesis: identification of the tryptophan to quinolinate pathway in bacteria.
    Chemistry & biology, 2003, Volume: 10, Issue:12

    Topics: Arylformamidase; Bacteria; Chromosomes, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genetic Complementation Test; Hydrolases; Kinetics; Molecular Sequence Data; NAD; Oxidoreductases; Quinolinic Acid; Tryptophan

2003
Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
    Bioscience, biotechnology, and biochemistry, 2004, Volume: 68, Issue:1

    Topics: Animals; Dose-Response Relationship, Drug; Eating; Liver; Male; NAD; NADP; Niacinamide; Nicotinic Acids; Predictive Value of Tests; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Weaning; Weight Gain

2004
The pyridine ring of NAD is formed by a nonenzymatic pericyclic reaction.
    Journal of the American Chemical Society, 2005, Jan-26, Volume: 127, Issue:3

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Dicarboxylic Acids; Dioxygenases; NAD; Nuclear Magnetic Resonance, Biomolecular; Pyridines; Quinolinic Acid

2005
Early steps in the biosynthesis of NAD in Arabidopsis start with aspartate and occur in the plastid.
    Plant physiology, 2006, Volume: 141, Issue:3

    Topics: Amino Acid Oxidoreductases; Arabidopsis; Aspartic Acid; Escherichia coli; Escherichia coli Proteins; Multienzyme Complexes; NAD; Pentosyltransferases; Plastids; Quinolinic Acid

2006
Theoretical studies of the quinolinic acid to nicotinic acid mononucleotide transformation.
    The Journal of organic chemistry, 2008, Dec-05, Volume: 73, Issue:23

    Topics: Carbon; Carbon Dioxide; Chemistry, Organic; Computational Biology; Decarboxylation; Models, Chemical; Models, Theoretical; NAD; Nicotinamide Mononucleotide; Orotidine-5'-Phosphate Decarboxylase; Quinolinic Acid; Software; Solvents; Thermodynamics

2008
Changes in pyridine metabolism profile during growth of trigonelline-forming Lotus japonicus cell cultures.
    Phytochemistry, 2008, Volume: 69, Issue:17

    Topics: Alkaloids; Carbon Radioisotopes; Cells, Cultured; Gene Expression Regulation, Plant; Lotus; NAD; Niacinamide; Nicotinamidase; Plant Proteins; Pyridines; Quinolinic Acid; Time Factors; Tritium

2008
Profiles of the biosynthesis and metabolism of pyridine nucleotides in potatoes (Solanum tuberosum L.).
    Planta, 2009, Volume: 231, Issue:1

    Topics: Carbon Isotopes; NAD; Niacinamide; Nucleotides; Organ Specificity; Plant Leaves; Plant Tubers; Quinolinic Acid; Solanum tuberosum; Time Factors; Tissue Extracts; Tritium

2009
The crystal structure of human alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase in complex with 1,3-dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis.
    The FEBS journal, 2009, Volume: 276, Issue:22

    Topics: Carboxy-Lyases; Crystallography, X-Ray; Dihydroxyacetone Phosphate; Glycolysis; Humans; NAD; Picolinic Acids; Protein Binding; Quinolinic Acid; Signal Transduction

2009
Neuroprotective effects of naturally occurring polyphenols on quinolinic acid-induced excitotoxicity in human neurons.
    The FEBS journal, 2010, Volume: 277, Issue:2

    Topics: Apigenin; Calcium Signaling; Catechin; Cells, Cultured; Curcumin; Enzyme Activation; Flavanones; Flavonoids; Humans; Hydrolyzable Tannins; L-Lactate Dehydrogenase; NAD; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type I; Phenols; Poly(ADP-ribose) Polymerases; Polyphenols; Quinolinic Acid; Tyrosine

2010
Liquid chromatography/time-of-flight mass spectrometry for the analysis of plant samples: a method for simultaneous screening of common cofactors or nucleotides and application to an engineered plant line.
    Plant physiology and biochemistry : PPB, 2011, Volume: 49, Issue:10

    Topics: Adenosine Triphosphate; Arabidopsis; Bacteria; Chromatography, Liquid; Magnetic Resonance Spectroscopy; NAD; Niacin; Niacinamide; Pentosyltransferases; Photosynthesis; Plant Extracts; Plant Leaves; Plants, Genetically Modified; Quinolinic Acid; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
Inducible NAD overproduction in Arabidopsis alters metabolic pools and gene expression correlated with increased salicylate content and resistance to Pst-AvrRpm1.
    The Plant journal : for cell and molecular biology, 2012, Volume: 70, Issue:4

    Topics: Arabidopsis; Cluster Analysis; Disease Resistance; Escherichia coli Proteins; Gene Expression Regulation, Plant; Host-Pathogen Interactions; Metabolome; NAD; Oligonucleotide Array Sequence Analysis; Pentosyltransferases; Plant Diseases; Plant Leaves; Plants, Genetically Modified; Pseudomonas syringae; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Salicylates; Transcriptome; Transgenes

2012
Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice.
    The Journal of nutrition, 2012, Volume: 142, Issue:12

    Topics: Animals; Body Weight; Disease Models, Animal; Eating; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD; Niacin; Niacinamide; Pentosyltransferases; Quinolinic Acid

2012
Quinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci.
    Journal of bacteriology, 2013, Volume: 195, Issue:4

    Topics: Amide Synthases; Bacterial Proteins; Cloning, Molecular; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Mutation; NAD; Niacin; Nicotinamide-Nucleotide Adenylyltransferase; Quinolinic Acid; Streptococcus pyogenes

2013
Secretion of quinolinic acid, an intermediate in the kynurenine pathway, for utilization in NAD+ biosynthesis in the yeast Saccharomyces cerevisiae.
    Eukaryotic cell, 2013, Volume: 12, Issue:5

    Topics: Biosynthetic Pathways; Culture Media, Conditioned; Gene Expression; Gene Knockout Techniques; Genes, Fungal; Kynurenine; Membrane Transport Proteins; Microbial Viability; NAD; Pentosyltransferases; Quinolinic Acid; Saccharomyces cerevisiae; Transcription, Genetic

2013
The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress.
    Cancer research, 2013, Jun-01, Volume: 73, Issue:11

    Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Line, Tumor; Dacarbazine; Drug Resistance, Neoplasm; Glioma; Humans; Microglia; NAD; Oxidative Stress; Pentosyltransferases; Quinolinic Acid; Temozolomide; Tryptophan; Tryptophan Oxygenase

2013
Enzymes that control the conversion of L-tryptophan-nicotinamide and the urinary excretion ratio (N(1)-methyl-2-pyridone-5-carboxamide + N(1)-methyl-4-pyridone-3-carboxamide)/N(1)-methylnicotinamide in mice.
    Bioscience, biotechnology, and biochemistry, 2013, Volume: 77, Issue:10

    Topics: Animals; Body Weight; Eating; Enzymes; Male; Mice; NAD; Niacinamide; Pyridones; Quinolinic Acid; Tryptophan

2013
Improvement of mitochondrial NAD(+)/FAD(+)-linked state-3 respiration by caffeine attenuates quinolinic acid induced motor impairment in rats: implications in Huntington's disease.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:6

    Topics: Animals; Antioxidants; Caffeine; Cell Respiration; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Flavin-Adenine Dinucleotide; Huntington Disease; Mitochondria; NAD; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Quinolinic Acid; Rats

2014
Tryptophan-Dependent Control of Colony Formation After DNA Damage via Sea3-Regulated TORC1 Signaling in Saccharomyces cerevisiae.
    G3 (Bethesda, Md.), 2015, May-04, Volume: 5, Issue:7

    Topics: Amino Acid Transport Systems; Bleomycin; DNA Damage; DNA Repair; Galactose; Mechanistic Target of Rapamycin Complex 1; Membrane Proteins; Multiprotein Complexes; NAD; Quinolinic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Telomere; TOR Serine-Threonine Kinases; Tryptophan

2015
Dual activity of quinolinate synthase: triose phosphate isomerase and dehydration activities play together to form quinolinate.
    Biochemistry, 2015, Oct-27, Volume: 54, Issue:42

    Topics: Aspartic Acid; Bacterial Proteins; Dihydroxyacetone Phosphate; Metabolic Networks and Pathways; Models, Chemical; Multienzyme Complexes; NAD; Quinolinic Acid; Thermotoga maritima; Triose-Phosphate Isomerase

2015
True Niacin Deficiency in Quinolinic Acid Phosphoribosyltransferase (QPRT) Knockout Mice.
    Journal of nutritional science and vitaminology, 2015, Volume: 61 Suppl

    Topics: Animals; Disease Models, Animal; Mice, Inbred C57BL; Mice, Knockout; Mutation; NAD; Niacin; Nutritional Status; Pentosyltransferases; Quinolinic Acid; Vitamin B Deficiency

2015
Modulation of NADH Levels by Arabidopsis Nudix Hydrolases, AtNUDX6 and 7, and the Respective Proteins Themselves Play Distinct Roles in the Regulation of Various Cellular Responses Involved in Biotic/Abiotic Stresses.
    Plant & cell physiology, 2016, Volume: 57, Issue:6

    Topics: Arabidopsis; Arabidopsis Proteins; Ascorbic Acid; Estrogens; Gene Expression Regulation, Plant; Genes, Plant; Mutation; NAD; Nudix Hydrolases; Oxidative Stress; Paraquat; Plants, Genetically Modified; Poly Adenosine Diphosphate Ribose; Pyrophosphatases; Quinolinic Acid; Salicylic Acid; Stress, Physiological

2016
Essential role of Bordetella NadC in a quinolinate salvage pathway for NAD biosynthesis.
    Molecular microbiology, 2017, Volume: 103, Issue:3

    Topics: Bacterial Proteins; Biosynthetic Pathways; Bordetella; Genes, Bacterial; Mutation; NAD; Pentosyltransferases; Quinolinic Acid

2017
Uridine monophosphate synthetase enables eukaryotic
    The Journal of biological chemistry, 2017, 07-07, Volume: 292, Issue:27

    Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Multienzyme Complexes; Mutation; NAD; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Quinolinic Acid; Tryptophan

2017
Crystallographic Trapping of Reaction Intermediates in Quinolinic Acid Synthesis by NadA.
    ACS chemical biology, 2018, 05-18, Volume: 13, Issue:5

    Topics: Crystallography, X-Ray; Molecular Docking Simulation; Multienzyme Complexes; NAD; Protein Conformation; Quinolinic Acid; Thermotoga maritima

2018
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
    Neurotoxicity research, 2019, Volume: 35, Issue:3

    Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; NAD; Neurons; Oxidative Stress; Primary Cell Culture; Quinolinic Acid; Reactive Oxygen Species

2019
The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate
    The Journal of biological chemistry, 2019, 04-05, Volume: 294, Issue:14

    Topics: Animals; Copper; Mice; NAD; Niacin; Nuclear Proteins; Quinolinic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirtuin 2; Transcription Factors

2019
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
    Frontiers in immunology, 2020, Volume: 11

    Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan

2020
Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae.
    Scientific reports, 2020, 12-03, Volume: 10, Issue:1

    Topics: Acetylation; Chromosomes, Fungal; DNA Damage; DNA Replication; Gene Deletion; Genomic Instability; Glucose; Glyceraldehyde-3-Phosphate Dehydrogenases; NAD; Quinolinic Acid; Saccharomyces cerevisiae

2020
Construction of an Alternative NAD
    Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021, Volume: 8, Issue:9

    Topics: Biochemical Phenomena; Cells, Cultured; Chorismic Acid; Escherichia coli; NAD; Quinolinic Acid

2021
Cell stress response impairs de novo NAD+ biosynthesis in the kidney.
    JCI insight, 2022, 01-11, Volume: 7, Issue:1

    Topics: Acute Kidney Injury; Animals; Cell Line; Endoplasmic Reticulum Stress; Kidney; Male; Mice; Mice, Inbred C57BL; NAD; Pentosyltransferases; Quinolinic Acid; Tryptophan

2022
Hepatocyte nuclear factor 4α mediated quinolinate phosphoribosylltransferase (QPRT) expression in the kidney facilitates resilience against acute kidney injury.
    Kidney international, 2023, Volume: 104, Issue:6

    Topics: Acute Kidney Injury; Animals; Hepatocyte Nuclear Factors; Kidney; Mice; NAD; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Quinolinic Acid; Tryptophan

2023