quinolinic acid has been researched along with kynurenine in 326 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (3.37) | 18.7374 |
| 1990's | 76 (23.31) | 18.2507 |
| 2000's | 61 (18.71) | 29.6817 |
| 2010's | 103 (31.60) | 24.3611 |
| 2020's | 75 (23.01) | 2.80 |
| Authors | Studies |
|---|---|
| Pewnim, T; Seifert, J | 1 |
| Schwab, F; Vécsei, L | 1 |
| Bhalla, RB; Brew, BJ; Der, M; Heyes, MP; Lee, K; Markey, SP; Price, RW; Quearry, BJ; Saito, K | 1 |
| Harati, Y; Heyes, MP; McKinley, K; Quearry, B; Silver, RM; Smith, EA; Sternberg, EM | 1 |
| Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K | 1 |
| Heyes, MP; Markey, SP; Saito, K | 3 |
| Halperin, JJ; Heyes, MP | 1 |
| Carreira, P; Heyes, MP; Silver, RM; Sutherland, SE | 1 |
| Schwarcz, R; Ungerstedt, U; Wu, HQ | 2 |
| Pastukhov, VA | 1 |
| Du, F; Schwarcz, R | 1 |
| Rios, C; Santamaria, A | 1 |
| Heyes, MP; Quearry, BJ | 1 |
| Fukui, S; Rapoport, SI; Schwarcz, R; Smith, QR; Takada, Y | 1 |
| Abramson, FP; Bacher, JD; Boni, RL; Heyes, MP; Ji, XD; Markey, SP; Yergey, JA | 1 |
| During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Matson, WR; Roth, RH; Swartz, KJ | 1 |
| Gramsbergen, JB; Schwarcz, R; Speciale, C; Vezzani, A | 1 |
| Heyes, MP; Lackner, A | 1 |
| Lapin, IP; Ryzov, IV | 1 |
| Artem'ev, IIu | 1 |
| Heyes, MP; Markey, SP; Quearry, BJ | 1 |
| Khaspekov, LG; Lapin, IP; Ryzhov, IV; Viktorov, IV | 1 |
| Connick, JH; Stone, TW | 1 |
| Lapin, IP; Ryzhov, IV | 2 |
| Aleksandrov, VG; Lapin, IP; Mandel'shtam, IuE; Ryzhov, IV; Slepokurov, MV | 1 |
| Schwarcz, R; Speciale, C; Ungerstedt, U | 1 |
| Zarkovsky, AM | 1 |
| Perkins, MN; Stone, TW | 1 |
| Lapin, IP | 1 |
| Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA | 1 |
| Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K | 1 |
| Eastman, CL; Guidetti, P; Schwarcz, R | 1 |
| Carpenedo, R; Chiarugi, A; Mattoli, L; Molina, MT; Moroni, F; Pellicciari, R | 1 |
| Boni, RL; Markey, SP; Naritsin, DB | 1 |
| Carlà, V; Carpenedo, R; Chiarugi, A; Lombardi, G; Mattoli, L; Moroni, F; Pellicciari, R; Russi, P | 1 |
| Altagracia, M; Gonzalez, L; Kravzov, J; Ordaz, H; Ríos, C; Santamaría, A; Solís, F | 1 |
| Blight, AR; Heyes, MP; Saito, K | 1 |
| Crowley, JS; Heyes, MP; Markey, SP; Nowak, TS; Quearry, BJ; Saito, K; Saito, M; Suyama, K | 1 |
| Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH | 1 |
| Chase, TN; Jauch, DA; Schwarcz, R; Sethy, VH; Weick, BG | 1 |
| Crowley, JS; Heyes, MP; Markey, SP; Saito, K | 1 |
| Heyes, MP; Markey, SP; Nowak, TS; Saito, K | 1 |
| Schwarcz, R | 1 |
| Chen, CY; Crowley, JS; Heyes, MP; Markey, SP; Masana, M; Saito, K | 1 |
| Schapira, AH | 1 |
| Heyes, MP; Milstien, S; Saito, K; Schiff, SJ | 1 |
| Flanagan, EM; Iyer, R; Madge, DJ; Reinhard, JF; Salter, M | 1 |
| Espey, MG; Gajdusek, DC; Gibbs, CJ; Moffett, JR; Namboodiri, MA; Narayanan, R; Venkateshan, CN | 1 |
| Altagracia, M; González-Reynoso, L; Kravzov, J; Ordaz-Moreno, J; Ríos, C; Santamaría, A; Solís-Hernández, F | 1 |
| Katsuki, H; Nakagami, Y; Saito, H | 1 |
| Heyes, MP | 1 |
| Fuchs, D; Gisslén, M; Hagberg, L; Larsson, M; Norkrans, G; Wachter, H | 1 |
| Heyes, MP; Markey, SP; Noma, A; Saito, K; Seishima, M | 1 |
| Behan, WM; Graham, DI; Jones, P; MacGregor, DG; Smith, RA; Stone, TW | 1 |
| Fornstedt-Wallin, B; Fredriksson, G; Luthman, J; Vänerman, E | 1 |
| Guzeva, VI; Melnikova, NV; Mikhailov, IB | 1 |
| Heyes, MP; Markey, SP; Noma, A; Saito, K; Seishima, M; Suyama, K | 1 |
| Heyes, MP; Markey, SP; Nagamura, Y; Noma, A; Quearry, BJ; Saito, K; Seishima, M | 1 |
| Heyes, MP; Saito, K | 1 |
| Blinder, K; Gajdusek, DC; Gibbs, CJ; Gravell, M; Moffett, JR; Namboodiri, AM; Narayanan, R; Venkateshan, CN | 1 |
| Achim, CL; Heyes, MP; Major, EO; Markey, SP; Saito, K; Wiley, CA | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF | 1 |
| Ceresoli, G; Guidetti, P; Schwarcz, R | 1 |
| Chen, CY; Heyes, MP; Major, EO; Saito, K | 1 |
| Beagles, KE; Chen, CY; Heyes, MP; Kawai, K; Li, J; Markey, SP; Nowak, TS; Proescholdt, MA; Proescholdt, MG; Saito, K; Zito, MA | 1 |
| Espey, MG; Gibbs, CJ; Moffett, JR; Namboodiri, MA; Sung, V; Venkateshan, CN; Ward, R; Williamson, L | 1 |
| Armati, PJ; Brew, BJ; Kerr, SJ; Pemberton, LA; Smythe, G; Tattam, B | 1 |
| Dong-Ryul, L; Furukawa, S; Kondo, H; Nakano, K | 1 |
| Chaudhri, G; Hunt, NH; Moore, DE; Sanni, LA; Stocker, R; Tattam, BN; Thomas, SR | 1 |
| Reinhard, JF | 2 |
| Dong-Ruyl, L; Nakano, K; Sawada, M | 1 |
| Beninger, RJ; Boegman, RJ; Harris, CA; Jhamandas, K; Miranda, AF; Tanguay, JJ | 1 |
| Achim, CL; Heyes, MP; Lackner, A; Markey, SP; Saito, K; Wiley, CA | 1 |
| Blinder, KL; Moffett, JR; Namboodiri, MA; Venkateshan, CN | 1 |
| Goodman, CB; Heyliger, SO; Ngong, JM; Soliman, KF | 1 |
| Hodgkins, PS; Schwarcz, R | 1 |
| Brown, OR; Dang, Y; Xia, C | 1 |
| Chiarugi, A; Moroni, F | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF; Sutton, MA | 1 |
| Handley, SL; Kariyawasam, SH | 1 |
| Guidetti, P; Schwarcz, R | 2 |
| Lee, SC; Schwarcz, R; Wu, HQ | 1 |
| Armati, PJ; Brew, BJ; Guillemin, GJ; Kerr, SJ; Smythe, GA | 1 |
| Behan, WM; Stone, TW | 1 |
| Guidetti, P; Schwarcz, R; Wu, HQ | 1 |
| Ceresoli-Borroni, G; Goodman, JH; Guidetti, P; Scharfman, HE; Schwarcz, R; Speciale, C; Varasi, M; Wu, HQ | 1 |
| Stone, TW | 3 |
| Armati, PJ; Brew, BJ; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA | 1 |
| Chiarugi, A; Dello Sbarba, P; Donnini, S; Filippi, S; Moroni, F; Paccagnini, A | 1 |
| Allen, RH; Altfeld, M; Kreuzer, KA; Look, MP; Riezler, R; Rockstroh, JK; Sauerbruch, T; Stabler, SP | 1 |
| Fujigaki, S; Fujii, H; Heyes, MP; Noma, A; Saito, K; Seishima, M; Shibata, K; Takemura, M; Wada, H | 1 |
| Brown, OR; Dale, WE; Dang, Y | 1 |
| Baran, H; Gille, L; Kepplinger, B; Nohl, H; Staniek, K; Stolze, K | 1 |
| Lee, SC; Schwarcz, R | 1 |
| Chiarugi, A; Meli, E; Moroni, F | 1 |
| Baraldi, M; Cannazza, G; Zanoli, P | 1 |
| Armati, PJ; Brew, BJ; Croitoru, J; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA | 1 |
| Calvani, M; Chiarugi, A; Meli, E; Moroni, F; Traggiai, E | 1 |
| Buczko, W; Pawlak, D; Tankiewicz, A | 1 |
| Armati, PJ; Brew, BJ; Guillemin, GJ; Kerr, SJ; Pemberton, LA; Smith, DG; Smythe, GA | 1 |
| Braga, O; Brew, BJ; Grant, RS; Guillemin, GJ; Kerr, SJ; Smythe, GA; Walker, DW | 1 |
| Chau, TT; Chu'ong, LV; Day, NP; Farrar, J; Hien, TT; Hunt, NH; Mai, NT; Medana, IM; Phu, NH; Salahifar, H; Smythe, G; Stocker, R; Taylor, A; Turner, GD; White, NJ | 1 |
| Buczko, W; Mysliwiec, P; Pawlak, D; Tankiewicz, A | 1 |
| Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Heyes, MP; Kita, T; Markey, SP; Morrison, PF | 1 |
| Bianchi, R; Fallarino, F; Fioretti, MC; Grohmann, U; Orabona, C; Puccetti, P; Spreca, A; Vacca, C | 1 |
| Pellicciari, R; Schwarcz, R | 1 |
| Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
| Brew, BJ; Guillemin, GJ | 1 |
| Moffett, JR; Namboodiri, MA | 1 |
| Clark, CJ; Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW | 1 |
| Bwanaisa, L; Day, NP; Hunt, NH; Kayira, K; Medana, IM; Njobvu, A; Salahifar-Sabet, H; Smythe, G; Stocker, R; Taylor, TE; Turner, GD | 1 |
| BROWN, RR; HANKES, LV | 1 |
| Cerstiaens, A; De Loof, A; Huybrechts, J; Kotanen, S; Lebeau, I; Meylaers, K; Schoofs, L | 1 |
| Armati, PJ; Brew, BJ; Guillemin, GJ; Smith, DG; Smythe, GA | 1 |
| Fujii, H; Furuta, N; Maeda, S; Ohashi, H; Saito, K; Seishima, M; Takemura, M; Wada, H | 1 |
| Cai, T; Chen, A; Di Prospero, NA; Du, F; Guidetti, P; Melendez-Ferro, M; Sapko, MT; Schwarcz, R; Tagle, DA; Whetsell, WO; Yu, P | 1 |
| Rho, JM | 1 |
| Brew, BJ; Guillemin, GJ; Smythe, G; Takikawa, O | 1 |
| Brew, BJ; Cullen, KM; Guillemin, GJ; Noonan, CE; Takikawa, O | 1 |
| Brown, AR; Kranz, DM; Roy, EJ; Takikawa, O; Thomas, DL | 1 |
| Guidetti, P; Pellicciari, R; Sapko, MT; Schwarcz, R; Tagle, DA; Yu, P | 1 |
| Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B | 1 |
| Brew, BJ; Guillemin, GJ; Meininger, V | 1 |
| Németh, H; Toldi, J; Vécsei, L | 1 |
| Amori, L; Ceresoli-Borroni, G; Guidetti, P; Pellicciari, R; Schwarcz, R | 1 |
| Darlington, LG; Forrest, CM; Mackay, GM; Stone, TW; Stoy, N | 1 |
| Bédard, PJ; Di Paolo, T; Grégoire, L; Guidetti, P; Izzo, E; Rassoulpour, A; Samadi, P; Schwarcz, R | 1 |
| Bosmans, E; Kubera, M; Maes, M; Mihaylova, I; Ruyter, MD | 1 |
| Bertram, EH; Guidetti, P; Lehrmann, E; Löve, A; Schwarcz, R; Williamson, J | 1 |
| Bannink, M; Eggermont, AM; Fekkes, D; Hengeveld, MW; Kruit, WH; Scharpé, S; Sleijfer, S; Stoter, G; van der Holt, B; Van Gool, AR; Verkerk, R | 1 |
| Ball, HJ; Hunt, NH; Mellor, AL; Miu, J | 1 |
| Lima, WC; Menck, CF; Varani, AM | 1 |
| Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Amori, L; Guidetti, P; Marinozzi, M; Pellicciari, R; Schwarcz, R; Wu, HQ | 1 |
| Bilgin, A; Coggan, SE; Grant, RS; Smythe, GA | 1 |
| Fotopoulou, C; Hasper, D; Pschowski, R; Reinke, P; Schefold, JC; Schuett, C; Volk, HD; von Haehling, S; Zeden, JP | 1 |
| Egashira, Y; Sanada, H; Sasaki, N | 1 |
| Guidetti, P; Muchowski, PJ; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Buczko, W; Dadan, J; Myśliwiec, H; Myśliwiec, P; Pawlak, D; Pawlak, K | 1 |
| Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Dantzer, R; Kelley, KW; Lawson, MA; Miller, AH; Raison, CL; Saito, K; Spivey, JR; Vogt, G; Woolwine, BJ | 1 |
| Brew, BJ; Chen, Y; Coggan, S; Cullen, KM; Garner, B; Grant, R; Guillemin, GJ; Meininger, V; Stankovic, R | 1 |
| Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP | 1 |
| Chen, Y; Guillemin, GJ; Meininger, V | 1 |
| Kincses, ZT; Toldi, J; Vécsei, L | 1 |
| Bien, B; Gulaj, E; Pawlak, D; Pawlak, K | 1 |
| Bieber, T; Brenk, M; Koch, S; Scheler, M; von Bubnoff, D; Wilms, H | 1 |
| Braidy, N; Chan-Ling, T; Grant, R; Guillemin, GJ; Mansour, H | 1 |
| Ammer, J; Andreesen, R; Edinger, M; Holler, B; Holler, E; Kreutz, M; Landfried, K; Oefner, PJ; Peter, K; Schulz, U; Waldhier, MC; Wolff, D; Zhu, W | 1 |
| Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Melzig, MF; Wszelaki, N | 1 |
| Brew, BJ; Kandanearatchi, A | 1 |
| Du Preez, JL; Emsley, R; Harvey, BH; Möller, M | 1 |
| Du Preez, JL; Harvey, BH; Möller, M | 1 |
| Chan-Ling, T; Combes, V; Grau, GE; Guillemin, GJ; Hunt, NH | 1 |
| Tan, L; Yu, JT | 1 |
| Plangar, I; Szalardy, L; Vecsei, L | 1 |
| Darlington, LG; Stone, TW; Stoy, N | 1 |
| Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ | 1 |
| Brundin, L; Erhardt, S; Guillemin, GJ; Janelidze, S; Lim, CK; Linderholm, KR; Lindqvist, D; Lundberg, K; Postolache, TT; Samuelsson, M; Träskman-Bendz, L | 1 |
| Kawai, S; Murata, K; Ohashi, K | 1 |
| Bishnupuri, KS; Ciorba, MA; Foster, L; Kerr, TA; Marinshaw, JM; Newberry, RD; Rao, MS; Stenson, WF; Thaker, AI | 1 |
| Fukuwatari, T; Funakoshi, H; Kadota, E; Kanai, M; Nakamura, T; Sano, M; Shibata, K; Terakata, M | 1 |
| Adomat, H; Budac, DP; Leavitt, BR; Lu, G; Mazarei, G; Möller, T; Tomlinson Guns, ES | 1 |
| Dijkhuis, A; Johnston, SL; Karlas, JA; Kulik, W; Lutter, R; Molenkamp, R; Smids, BS; Sterk, PJ; van de Pol, MA; van der Sluijs, KF; van der Zee, JS; van Eijk, HW; Wolthers, KC | 1 |
| Chobot, V; Hadacek, F; Kubicova, L | 1 |
| Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH | 1 |
| Ali, SF; Colín-González, AL; Königsberg, M; Luna-López, A; Pedraza-Chaverrí, J; Santamaría, A | 1 |
| Dantzer, R; Walker, AK | 1 |
| Aguesse, A; Castellano, B; Darmaun, D; Ferchaud-Roucher, V; Nael, C; Poupeau, G; Sano, M | 1 |
| Banister, SD; Guillemin, GJ; Karl, T; Kassiou, M; Lim, CK; Purves-Tyson, T; Weickert, CS; Zavitsanou, K | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Bay-Richter, C; Brundin, L; Erhardt, S; Guillemin, GJ; Lim, CK; Linderholm, KR; Samuelsson, M; Träskman-Bendz, L | 1 |
| Bustamante, S; Campbell, B; Hejazi, L; Leong, RW; Pickford, R; Shin, S; Wasinger, VC; Yau, YY | 1 |
| Adams, S; Braidy, N; Brew, BJ; Bustamante, S; Guillemin, GJ; Lim, CK; McDonald, KL; Sundaram, G; Teo, C; Zinger, A | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Adams, S; Brew, BJ; Guillemin, GJ; Jones, SP; Lim, CK; Sundaram, G | 1 |
| Andreassen, OA; Brundin, L; Dahl, J; Malt, UF; Ormstad, H; Sandvik, L; Verkerk, R | 1 |
| Drewes, JL; Gama, L; Graham, DR; Li, M; Liao, Z; Meulendyke, KA; Notarangelo, FM; Schwarcz, R; Tarwater, PM; Ubaida-Mohien, C; Witwer, KW; Zink, MC | 1 |
| Frugier, T; Guillemin, GJ; Heng, B; Lim, CK; Morganti-Kossmann, MC; Rosenfeld, JV; Sundaram, G; Tan, M; Walker, DW; Yan, EB | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; McIntosh, SA; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Bipath, P; Levay, PF; Viljoen, M | 1 |
| Amouzadeh-Ghadikolai, O; Baranyi, A; Breitenecker, RJ; Meinitzer, A; Rothenhäusler, HB; Stauber, R | 1 |
| Bellgowan, PS; Meier, TB; Savitz, J; Singh, R; Teague, TK | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Buttar, HS; Nayak, BN | 1 |
| de Bie, J; Grant, R; Guest, J; Guillemin, GJ | 1 |
| Kaminski, T; Michalowska, M; Oksztulska-Kolanek, E; Pawlak, D; Znorko, B | 1 |
| Gandhi, CP; Hill, MN; Vecchiarelli, HA | 1 |
| Buras, A; Szulc, A; Waszkiewicz, N | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Teague, TK; Young, KD | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M | 1 |
| Bhat, M; Choi, DS; Engberg, G; Erhardt, S; Faka, A; Goiny, M; Imbeault, S; Larsson, MK; Liu, XC; Oliveros, A; Orhan, F; Sandberg, K; Schwieler, L; Ståhl, S | 1 |
| Budac, DP; Elfving, B; Eskelund, A; Sanchez, C; Wegener, G | 1 |
| Braidy, N; Brew, BJ; Guillemin, GJ; Lee, JM; Lovejoy, D; Rowe, DB; Tan, V | 1 |
| Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R | 1 |
| Allorge, D; Caiazzo, R; Favennec, M; Froguel, P; Guillemin, GJ; Hennart, B; Leloire, A; Pattou, F; Pigeyre, M; Poulain-Godefroy, O; Raverdy, V; Verbanck, M; Verkindt, H; Yengo, L | 1 |
| Brundin, L; Brundin, P; Erhardt, S; Fuchs, D; Grit, J; Guillemin, GJ; Landén, M; Lim, CK; Lundgren, K; Pålsson, E; Postolache, TT; Samuelsson, M; Sellgren, CM; Traskman-Bendz, L | 1 |
| Bezard, E; Camus, SM; Ceci, A; Fuertig, R; Hengerer, B; Luippold, AH | 1 |
| Bhat, M; Erhardt, S; Orhan, F; Piehl, F; Sandberg, K; Schwieler, L; Ståhl, S; Svensson, C | 1 |
| Lancaster, MA; Mayer, AR; Meier, TB; Savitz, J; Teague, TK | 1 |
| Aguilera, G; Colín-González, AL; Santamaría, A | 1 |
| Al-Dhabi, NA; Bai, M; Duraipandiyan, V; Liu, G; Liu, H; Oso, AO; Tossou, MC; Wu, X; Xi, Q; Xu, K; Yin, Y | 1 |
| Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Kapfhammer, HP; Maget, A; Mangge, H; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, B; Reininghaus, EZ; Schütze, G; Schwarz, M; Zelzer, S | 1 |
| Ablasser, K; Alesutan, I; Belyavskiy, E; Brussee, H; Catena, C; Fahrleitner-Pammer, A; Grübler, MR; Kolesnik, E; Lewinski, DV; März, W; Meinitzer, A; Pieske, B; Pieske-Kraigher, E; Pilz, S; Schwetz, V; Sechi, LA; Tomaschitz, A; Trummer, C; Verheyen, N; Voelkl, J | 1 |
| Briese, T; Formisano, S; Hornig, M; Lipkin, WI; Parsons, LH; Vasishtha, M; Williams, BL; Yaddanapudi, K | 1 |
| Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE | 1 |
| Parasram, K | 1 |
| Cho, HJ; Dantzer, R; Drevets, WC; Irwin, MR; Savitz, J; Teague, TK | 1 |
| Leonard, BE | 1 |
| Advani, R; Giil, LM; Midttun, Ø; Refsum, H; Smith, AD; Ueland, PM; Ulvik, A | 1 |
| Neale, SA; Salt, TE; Sathyasaikumar, KV; Schwarcz, R; Tararina, M; Weisz, F; Wu, HQ | 1 |
| Robertson, DS | 1 |
| Makino, R; Okuyama, H; Tachibana, T; Tomonaga, S | 1 |
| Czarny, P; Galecki, P; Sliwinski, T; Wigner, P | 1 |
| Chen, B; Guo, J; He, S; Hu, J; Hu, L; Huang, X; Li, X; Qi, Y; Shang, D; Wang, J; Wen, Y | 1 |
| Duan, KM; Huang, Z; Ma, JH; Wang, SY; Yu, H; Zhou, Y | 1 |
| Arnhard, K; Fuchs, D; Koal, T; Oberacher, H; Pitterl, F; Sperner-Unterweger, B | 1 |
| Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D | 1 |
| Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M | 1 |
| Bryn, V; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H | 1 |
| Delgado, J; Garrison, AM; O'Connor, JC; Parrott, JM; Redus, L; Tuñon, A | 1 |
| Allers, KA; Doolin, K; Farrell, C; Frodl, T; Harkin, A; Liesener, A; O'Hanlon, E; O'Keane, V; Pleiner, S; Roddy, D; Tozzi, L | 1 |
| Arnone, D; Dantzer, R; Salem, H; Saraykar, S; Selvaraj, S; Teixeira, AL | 1 |
| Kanchanatawan, B; Maes, M | 1 |
| Bryn, V; Halvorsen, B; Isaksen, J; Maes, M; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Badawy, AA | 1 |
| Botticelli, A; Cerbelli, B; Federica, M; Lionetto, L; Marchetti, P; Nuti, M; Pisano, A; Salati, M; Simmaco, M; Zizzari, I | 1 |
| Duan, K; Quan, C; Tan, Y; Wang, S; Wen, S; Zhang, J | 1 |
| Bansal, Y; Kuhad, A; Razdan, K; Sharma, R | 1 |
| Atzori, M; García-Oscos, F; Pérez-Padilla, EA; Pineda, JC; Ramírez, LA; Salgado, H | 1 |
| Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y | 1 |
| Carrillo Mora, P; García Muñoz, I; García-Juárez, B; Gómez-Manzo, S; González-Esquivel, D; Jiménez Herrera, B; Marcial-Quino, J; Pérez de la Cruz, G; Pérez de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Ramos-Chávez, LA; Ríos, C; Roldán-Roldán, G; Sánchez Chapul, L | 1 |
| Adams, S; Castellano-Gonzalez, G; Cole, NJ; Don, E; Guillemin, GJ; Jacobs, KR; Lim, CK; Lovejoy, DB | 1 |
| Choi, BT; Kim, H; Kim, MJ; Koo, YS; Lee, SY; Park, JH; Shin, HK; Shin, YI | 1 |
| Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M | 1 |
| Böhmová, A; Horáček, J; Kodym, P; Krsek, D; Mikoška, M; Syslová, K; Tejkalová, H; Vacek, L; Vondroušová, J | 1 |
| Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R | 1 |
| Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H | 1 |
| Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM | 1 |
| Blesa, R; Carmona-Iragui, M; Costello, JC; Culp-Hill, R; D'Alessandro, A; Espinosa, JM; Fortea, J; Granrath, RE; Joshi, M; Kahn, DE; Lewis, HC; Lleó, A; Ludwig, MP; Minter, R; Powers, RK; Rachubinski, AL; Smith, KP; Sullivan, KD; Tuttle, KD; Waugh, KA; Wilkerson, RB | 1 |
| Akbari, V; Amani, M; Esmaeili, S; Ghobadi, N; Ghobadi, S; Jalalvand, AR; Khodarahmi, R; Moradi, S; Shahlaie, M | 1 |
| Duan, K; Hu, N; Huang, Z; Long, G; Ma, J; Quan, C; Wang, S; Yang, M; Yu, H; Zeng, G | 1 |
| Bloch, W; Hardt, L; Joisten, N; Kiesl, D; Knoop, A; Koliamitra, C; Kummerhoff, F; Metcalfe, AJ; Schenk, A; Thevis, M; Walzik, D; Zimmer, P | 1 |
| Arun, P; Badawy, AA; Ives, JA; Moffett, JR; Namboodiri, AM; Puthillathu, N; Vengilote, R | 1 |
| Bai, Y; Cui, Z; Li, P; Li, Y; Wang, D; Wang, Y; Zhang, J; Zheng, J | 1 |
| Coppens, V; De Picker, L; Kampen, JK; Morrens, M | 1 |
| Aydemir, Ö; Kandemir, H; Öztürk, M; Taneli, F; Yalın Sapmaz, Ş | 1 |
| Boeira, SP; Cattelan Souza, L; Giacomeli, R; Jesse, CR; Prigol, M; Silva, MRP; Zarzecki, MS | 1 |
| Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C; Misiak, B; Savitz, JB | 1 |
| Iqbal, T; Lijffijt, M; Mathew, SJ; Murphy, N; Ramakrishnan, N; Smith, MA; Swann, AC; Vo-Le, B | 1 |
| David-Bercholz, J; Harkin, A; Midttun, O; O'Farrell, K; O'Reilly, K; Rakovets, Y | 1 |
| Cao, B; Chen, Y; McIntyre, RS; Pan, Z; Ren, Z; Wang, D | 1 |
| Drivsholm, N; Faurholt-Jepsen, M; Gelpi, M; Kirkegaard-Klitbo, DM; Knudsen, AD; Midttun, Ø; Nielsen, SD; Trøseid, M; Ueland, PM | 1 |
| Chiappelli, J; Cui, Y; Hong, LE; Huang, J; Kochunov, P; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y | 1 |
| Cathomas, F; Guetter, K; Kaiser, S; Klaus, F; Seifritz, E | 1 |
| Chawdhury, ASMMR; Liu, A; Miller, A; Shamsi, SA | 1 |
| Bao, CH; Chen, LM; Huang, Y; Liang, SH; Liu, HR; Wang, D; Wu, HG; Wu, LY; Wu, Y | 1 |
| Meier, TB; Savitz, J | 1 |
| Antunes Soares, FA; Aschner, M; Bicca Obetine Baptista, F; Duarte Hartmann, D; Farina Gonçalves, D; Franzen da Silva, A; Lenz Dalla Corte, C; Limana da Silveira, T; Lopes Machado, M; Marafiga Cordeiro, L | 1 |
| Hoffman, WH; Lee, N; Whelan, SA | 1 |
| Notarangelo, FM; Schwarcz, R | 1 |
| Braidy, N; Guillemin, GJ; Joisten, N; Ruas, JL; Zimmer, P | 1 |
| de Timary, P; Delzenne, NM; Leclercq, S; Schwarz, M; Stärkel, P | 1 |
| Bou Khalil, R; El Khoury, R | 1 |
| Ciapała, K; Mika, J; Rojewska, E | 1 |
| Anderson, EW; Aranow, C; Diamond, B; Fishbein, J; Furie, RA; Hong, J; Mackay, M; Roeser, J; Volpe, BT | 1 |
| Bugiani, M; Dijkhuis, A; Duitman, JW; Geeraerts, Z; Guo, L; Lutter, R; Nossent, EJ; Roos, E; Schurink, B; van der Valk, P; van Vught, L; Vaz, FM; Vlaar, AP; Yeh, SR | 1 |
| Ostapiuk, A; Urbanska, EM | 1 |
| Brew, BJ; Guillemin, GJ; Heng, B; Krishnamurthy, S; Pires, AS; Sundaram, G | 1 |
| Kurzepa, J; Parada-Turska, J; Wnorowska, S; Wnorowski, A | 1 |
| Fukushima, T; Onozato, M; Sakamoto, T; Umino, M | 1 |
| Asratian, A; Boda, S; Dantzer, R; Erhardt, S; Hamilton, JP; Heilig, M; Holm, L; Kämpe, R; Paul, ER; Samuelsson, M; Schwieler, L; Trepci, A; Yngve, A | 1 |
| Altunçekiç Yıldırım, A; Ceran Serdar, C; Cihan, M; Doğan, Ö; Kurt, C; Serdar, MA | 1 |
| He, Y; Liang, Y; Qiao, X; Wu, W; Xie, S; Xu, M; Zhu, Y | 1 |
| Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Fortier, MV; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Michael, N; Sadananthan, SA; Tan, KH; Tan, KM; Tint, MT; Velan, SS; Yap, F | 1 |
| Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Tan, KH; Tan, KM; Tint, MT; Yap, F | 1 |
| Chen, J; Chen, L; Cheng, G; Han, Z; Li, M; Li, R; Li, Y; Liu, Y; Shu, Y; Sun, C; Wang, C; Wang, J; Zhao, J | 1 |
| Chandra, M; Debnath, C; Kohli, E; Mohanty, H; Prasad, DN; Reddy, MPK; Verma, K | 1 |
| Al-Hakeim, HK; Almulla, AF; Maes, M; Solmi, M; Tunvirachaisakul, C; Vasupanrajit, A; Verkerk, R | 1 |
| Chen, Q; Chen, W; Kong, Q; Mao, X; Wang, G; Zhang, H; Zhao, J | 1 |
| Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA | 1 |
| Abusoglu, S; Eryavuz Onmaz, D; Kuzu, M; Sivrikaya, A; Tezcan, D; Unlu, A; Yerlikaya, FH; Yilmaz, S | 1 |
| Li, R; Long, X; Mu, L; Qiao, J; Wang, S; Zhang, C; Zhang, Y; Zhao, Y | 1 |
| Bansal, Y; Bishnoi, M; Dhingra, N; Dhingra, R; Khare, P; Kondepudi, KK; Kuhad, A; Singh, R; Sodhi, RK | 1 |
| Aupperle, RL; Burrows, K; Figueroa-Hall, LK; Khalsa, SS; Paulus, MP; Savitz, J; Teague, TK; Yeh, FC; Zheng, H | 1 |
| Boersma, E; Boomars, KA; Cai, Z; de Rijke, YB; Duncker, DJ; Geenen, LW; Guignabert, C; Kema, I; Klein, T; Koudstaal, T; Merkus, D; Reiss, IKM; Tian, S; Tran-Lundmark, K; Tu, L; van den Bosch, AE; van der Ley, C; Van Faassen, M | 1 |
| Aaseth, JO; Alexander, J; Hestad, K; Rootwelt, H | 1 |
| da Silva Buss, Z; da Silva, RAL; de Arruda, CM; de Lima, E; de Matos, YAV; de Oliveira, VV; Doneda, DL; Fernandes, IL; Rios-Santos, F; Rohden, CAH; Vandresen-Filho, S; Viola, GG | 1 |
| Arnhard, K; Fuchs, D; Geisler, S; Gleissenthall, GV; Kemmler, G; Mechtcheriakov, S; Oberacher, H; Schurr, T; Unterberger, C | 1 |
| Asakawa, T; Chen, W; Jia, X; Qin, W; Shi, Y | 1 |
| Andrea, G; Cristina, B; Fabio, T; Luca, P; M C, BJ; Nicoletta, B; Sara, C; Silvia, A; Silvio, B; Veronica, R | 1 |
| Fujigaki, H; Fujigaki, S; Hasegawa, M; Hirakawa, M; Kubota, H; Kunisawa, K; Mori, Y; Mouri, A; Nabeshima, T; Niijima, M; Saito, K; Yamamoto, Y | 1 |
| Ad, Y; Baar, K; Pathak, SJ; Ramsey, JJ; Rutkowsky, JM; Steffen, D; Tran, T; Zhou, Z | 1 |
| Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J | 1 |
| Akhtar, A; Bains, M; Kaur, J; Kuhad, A; Sah, SP | 1 |
| Alves-Filho, JC; Arruda, LM; Buqui, GA; Cecilio, NT; Cunha, FQ; Cunha, TM; Dagostin, A; Davoli-Ferreira, M; Fernandes Gomes, FI; Fonseca, MD; Gonçalves, WA; Guimarães, RM; Huang, L; Kusuda, R; Leão, RM; Lemos, H; Lopes, AH; Lopes, NP; Maganin, AG; Mauriz Marques, LM; Mellor, A; Mendes, AS; O'Connor, JC; Pacholczyk, G; Sant'Anna, MB; Santana, DA; Santana-Coelho, D; Silva, CE; Silva, RL; Souza, GR; Talbot, J | 1 |
| Ford, BN; Khalsa, S; Kuplicki, R; Paulus, MP; Savitz, J; Teague, TK | 1 |
| Cabral-Marques, O; Dugué, PA; Giil, LM; Giles, GG; Halaas, NB; Hodge, A; Idland, AV; McCann, A; Midttun, Ø; Nordrehaug, JE; Nygård, O; Solvang, SH; Tell, GS; Ueland, PM; Ulvik, A; Watne, LO | 1 |
| An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W | 1 |
| Anderson, EW; Aranow, C; Arazi, A; Diamond, B; Furie, RA; Goodwin, S; Jin, Y; Mackay, M; Roeser, J; Shih, A; Volpe, B | 1 |
| Fang, EF; Figved, W; Frihagen, F; Giil, LM; Godø, A; Halaas, NB; Hassel, B; Henjum, K; Idland, AV; Knapskog, AB; McCann, A; Myrstad, M; Neerland, BE; Pollmann, CT; Quist-Paulsen, E; Raeder, J; Selbæk, G; Ueland, PM; Watne, LO; Zetterberg, H | 1 |
| Fathi, M; Hajiesmaeili, M; Jazi, K; Klegeris, A; Mafi, Z; McElhinney, A; Mohamadkhani, A; Sayehmiri, F; Tavasol, A; Vakili, K; Yaghoobpoor, S | 1 |
| Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM | 1 |
| Benninga, MA; Boneh, RS; de Jonge, WJ; Emond, P; Ghiboub, M; Lefèvre, A; Sovran, B; Van Limbergen, JE; Verburgt, CM; Wine, E | 1 |
| Ahmad, NS; Embong, H; Makpol, S; Nasaruddin, ML; Phing, AH; Wan Zaidi, WA | 1 |
| Andrews, PI; Antony, J; Ardern-Holmes, S; Bandodkar, S; Chung, J; Dale, RC; Farrar, MA; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Jones, HF; Kandula, T; Keating, BA; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pillai, SC; Sampaio, H; Tantsis, E; Troedson, C; Webster, R; Yan, J | 1 |
| Andrews, PI; Ardern-Holmes, S; Bandodkar, S; Calvert, S; Dale, RC; Gill, D; Gupta, S; Han, VX; Kandula, T; Kothur, K; Malone, S; Menezes, MP; Mohammad, S; Patel, S; Subramanian, G; Thomas, T; Troedson, C; Waak, M; Yan, J | 1 |
| Fan, Y; Gao, R; Liu, W; Wang, J; Wang, S; Wu, L; Xu, H; Xu, L; Yao, H; Yu, J; Yu, Z; Zhang, J; Zhang, L; Zhou, M | 1 |
| Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y | 1 |
| Abusoglu, S; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Unlu, A | 1 |
| Baranyi, A; Enko, D; Herrmann, M; Meinitzer, A; Michaelis, S; Schnedl, WJ; Schneider, C; Zelzer, S | 1 |
| Mangoni, AA; Zinellu, A | 1 |
| Cetin, I; Dokuyucu, R; Simsek, S; Yildirim, V | 1 |
58 review(s) available for quinolinic acid and kynurenine
| Article | Year |
|---|---|
[Kynurenine and its metabolites in nervous system diseases].
Topics: Humans; Kynurenic Acid; Kynurenine; Nervous System Diseases; Quinolinic Acid; Quinolinic Acids | 1992 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases | 1991 |
Quinolinic acid and other kynurenines in the central nervous system.
Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Convulsants; Glutamates; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kynurenine; Neurotransmitter Agents; Pipecolic Acids; Quinolinic Acid; Quinolinic Acids; Rats; Retina; Synapses; Synaptic Transmission; Tryptophan Oxygenase | 1985 |
[Endogenous convulsants (review)].
Topics: Amino Acids; Animals; Carbolines; Cats; Cerebral Cortex; Convulsants; Cysteic Acid; Cysteine; Disease Models, Animal; Dogs; Estrogens; Folic Acid; Homocysteine; Kynurenine; Methionine; Mice; Neurotransmitter Agents; Prostaglandins; Pyridoxal Phosphate; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Spinal Cord | 1986 |
Metabolism and function of brain kynurenines.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
The use of toxins to elucidate neural function and disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain; Brain Diseases; Disease Models, Animal; Humans; Huntington Disease; Kynurenine; Neurotoxins; Parkinson Disease, Secondary; Quinolinic Acid | 1993 |
The kynurenine pathway and neurologic disease. Therapeutic strategies.
Topics: 3-Hydroxyanthranilic Acid; Animals; Gerbillinae; Guinea Pigs; Humans; Kynurenine; Macrophage Activation; Mice; Nervous System Diseases; Neurotoxins; Primates; Quinolinic Acid; Rats; Spinal Cord; Spinal Cord Injuries | 1996 |
Basic mechanisms of kynurenine actions in the central nervous system.
Topics: Animals; Anticonvulsants; Central Nervous System; Humans; Indoles; Kynurenic Acid; Kynurenine; Mammals; Neurons; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 1996 |
Kynurenine pathway enzymes in brain. Properties of enzymes and regulation of quinolinic acid synthesis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Dioxygenases; Humans; Hydrolases; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Lyases; Mixed Function Oxygenases; Oxygenases; Quinolinic Acid; Transaminases; Tryptophan Oxygenase | 1996 |
Endogenous neurotoxins from tryptophan.
Topics: Animals; Humans; Kynurenine; Nervous System Diseases; Neurotoxins; Quinolinic Acid; Tryptophan | 2001 |
Kynurenines in the CNS: from endogenous obscurity to therapeutic importance.
Topics: Animals; Central Nervous System; Central Nervous System Diseases; Humans; Kynurenine; Neurotoxins; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2001 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Parkinson Disease; Prodrugs; Quinolinic Acid; Schizophrenia | 2001 |
Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities.
Topics: Animals; Brain; Humans; Kynurenic Acid; Kynurenine; Neuroglia; Neurons; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2002 |
Implications of the kynurenine pathway and quinolinic acid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2002 |
Tryptophan and the immune response.
Topics: Animals; Dendritic Cells; Dioxygenases; Humans; Immune System; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; NAD; Oxygenases; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 2003 |
Tryptophan metabolites and brain disorders.
Topics: AIDS Dementia Complex; Brain Diseases; Central Nervous System Diseases; Humans; Huntington Disease; Kynurenine; Quinolinic Acid; Tryptophan | 2003 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan | 2004 |
Implications for the kynurenine pathway and quinolinic acid in amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Inflammation; Kynurenine; Models, Neurological; Motor Neurons; Quinolinic Acid; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1 | 2005 |
Kynurenines, Parkinson's disease and other neurodegenerative disorders: preclinical and clinical studies.
Topics: Animals; Humans; Kynurenine; Neurodegenerative Diseases; Parkinson Disease; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Tryptophan, adenosine, neurodegeneration and neuroprotection.
Topics: Adenosine; Animals; Hepatic Encephalopathy; Humans; Kynurenine; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Tryptophan | 2007 |
Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; Huntington Disease; Kynurenine; Mice; Mutation; Peptides; Quinolinic Acid; Rats; Receptors, Glutamate; Serotonin Plasma Membrane Transport Proteins; Tryptophan | 2010 |
Kynurenines, neurodegeneration and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biosynthetic Pathways; Humans; Kynurenine; Molecular Structure; Nerve Degeneration; Plaque, Amyloid; Quinolinic Acid; Tryptophan | 2010 |
The kynurenine pathway and quinolinic acid: pivotal roles in HIV associated neurocognitive disorders.
Topics: Central Nervous System Diseases; Cognition Disorders; HIV; HIV Infections; Humans; Kynurenine; Quinolinic Acid | 2012 |
The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.
Topics: Astrocytes; Communicable Diseases; Endothelial Cells; Humans; Inflammation; Kynurenine; Neurons; Quinolinic Acid | 2012 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2012 |
An expanding range of targets for kynurenine metabolites of tryptophan.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Oxidation-Reduction; Quinolinic Acid; Tryptophan | 2013 |
Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?
Topics: Animals; Blood-Brain Barrier; Depressive Disorder; Glutamic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neuroimmunomodulation; Quinolinic Acid | 2014 |
New insights into tryptophan and its metabolites in the regulation of bone metabolism.
Topics: Animals; Bone and Bones; Humans; Kynurenine; Melatonin; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates | 2015 |
[Depression and inflammation in rheumatic diseases].
Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Monoamine Oxidase; Pituitary-Adrenal System; Quinolinic Acid; Rheumatic Diseases; Serotonin | 2016 |
Involvement of quinolinic acid in the neuropathogenesis of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Humans; Kynurenine; Metabolic Networks and Pathways; Quinolinic Acid; Tryptophan | 2017 |
Cannabinoids: Glutamatergic Transmission and Kynurenines.
Topics: Animals; Brain; Cannabinoids; Humans; Kynurenine; Nervous System Diseases; Quinolinic Acid | 2016 |
A review of the immunomodulatory role of dietary tryptophan in livestock and poultry.
Topics: Animal Feed; Animals; Dietary Supplements; Humans; Immunity, Innate; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Livestock; Lymphocytes; Melatonin; Poultry; Quinolinic Acid; Serotonin; Swine; Tryptophan | 2017 |
Phytochemical treatments target kynurenine pathway induced oxidative stress.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan | 2018 |
Oxidative and Nitrosative Stress as Well as the Tryptophan Catabolites Pathway in Depressive Disorders.
Topics: Antidepressive Agents; Antioxidants; Biomarkers; Depression; Depressive Disorder; Disease Progression; Humans; Inflammation; Kynurenine; Metabolic Networks and Pathways; Nitric Oxide Synthase; Nitrosative Stress; Oxidative Stress; Quality of Life; Quinolinic Acid; Tryptophan | 2017 |
The role of tryptophan metabolism in postpartum depression.
Topics: Depression; Depression, Postpartum; Depressive Disorder, Major; Female; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2018 |
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines.
Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Humans; Immunity, Innate; Inflammation; Kynurenine; Mitochondria; Quinolinic Acid; Reactive Oxygen Species; Receptors, Glutamate; Signal Transduction | 2018 |
Kynurenine pathway in depression: A systematic review and meta-analysis.
Topics: Brain; Depression; Depressive Disorder; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2018 |
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan | 2018 |
Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Drug Development; Humans; Kynurenic Acid; Kynurenine; Neuroprotection; Neuroprotective Agents; Quinolinic Acid | 2018 |
A new theory of depression based on the serotonin/kynurenine relationship and the hypothalamicpituitary- adrenal axis
Topics: Animals; Bacterial Infections; Brain; Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Illness Behavior; Immunity, Innate; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interleukins; Kynurenine; Models, Neurological; Models, Psychological; Neuroglia; Peripheral Nervous System; Pituitary-Adrenal System; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Social Isolation; Stress, Psychological; Toll-Like Receptor 4; Tryptophan; Vaccines | 2018 |
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis.
Topics: Aged; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2020 |
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinolinic Acid; Tryptophan | 2021 |
Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis.
Topics: Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease.
Topics: Animals; Brain-Gut Axis; Depression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammatory Bowel Diseases; Kynurenine; Prognosis; Quality of Life; Quinolinic Acid; Signal Transduction; Tryptophan | 2021 |
The Kynurenine Pathway in Traumatic Brain Injury: Implications for Psychiatric Outcomes.
Topics: Brain Injuries, Traumatic; Humans; Inflammation; Kynurenine; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2022 |
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2021 |
The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives.
Topics: Analgesics; Animals; Biomarkers; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Metabolic Networks and Pathways; Neuralgia; Quinolinic Acid; Tryptophan | 2021 |
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Parkinson Disease; Quinolinic Acid; Signal Transduction | 2022 |
Recent advances in clinical trials targeting the kynurenine pathway.
Topics: Humans; Kynurenine; Male; Nervous System Diseases; Quinolinic Acid; Tryptophan | 2022 |
A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.
Topics: Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Humans; Kynurenine; Quinolinic Acid | 2022 |
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2022 |
The Role of Tryptophan Dysmetabolism and Quinolinic Acid in Depressive and Neurodegenerative Diseases.
Topics: Cytokines; Humans; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid; Tryptophan | 2022 |
Can kynurenine pathway be considered as a next-generation therapeutic target for Parkinson's disease? An update information.
Topics: 3-Hydroxyanthranilic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Levodopa; Parkinson Disease; Quinolinic Acid; Tryptophan | 2022 |
Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review.
Topics: Humans; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2022 |
Altered Tryptophan-Kynurenine Pathway in Delirium: A Review of the Current Literature.
Topics: Aged; Brain Diseases; Delirium; Humans; Immune System; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
A systematic review and meta-analysis of the kynurenine pathway of tryptophan metabolism in rheumatic diseases.
Topics: C-Reactive Protein; Humans; Kynurenine; Quinolinic Acid; Rheumatic Diseases; Tryptophan | 2023 |
10 trial(s) available for quinolinic acid and kynurenine
| Article | Year |
|---|---|
Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease.
Topics: Adult; Aged; Aged, 80 and over; Anti-HIV Agents; Antigens, CD; Drug Therapy, Combination; Female; HIV Infections; HIV-1; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Type II; Reverse Transcriptase Inhibitors; RNA, Viral; Treatment Outcome; Tryptophan; Viral Load | 2000 |
The clinical significance of cerebrospinal fluid levels of kynurenine pathway metabolites and lactate in severe malaria.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemether; Artemisinins; Humans; Kynurenine; Lactates; Malaria, Cerebral; Middle Aged; Picolinic Acids; Plasmodium falciparum; Quinine; Quinolinic Acid; Sesquiterpenes | 2002 |
Metabolites of the kynurenine pathway of tryptophan metabolism in the cerebrospinal fluid of Malawian children with malaria.
Topics: Adult; Child; Child, Preschool; Disease Progression; Humans; Kynurenine; Malaria, Cerebral; Malawi; Picolinic Acids; Quinolinic Acid; Retrospective Studies; Tryptophan; Vietnam | 2003 |
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Placebos; Protein Precursors; Quinolinic Acid; Sepsis; Serotonin; Shock, Septic; Treatment Outcome; Tryptophan | 2010 |
Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
Topics: Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Echocardiography; Female; Humans; Hyperparathyroidism, Primary; Inflammation; Kynurenine; Male; Quinolinic Acid; Tryptophan; Ventricular Remodeling | 2017 |
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha | 2019 |
Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
Topics: Adult; Cross-Over Studies; Endurance Training; Exercise; Humans; Hydrocortisone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Male; Quinolinic Acid; Resistance Training; Transaminases; Tryptophan | 2020 |
A randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-D-aspartate receptor blockade in healthy veterans.
Topics: Adult; Cross-Over Studies; Female; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Veterans | 2021 |
Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, crossover study.
Topics: Adult; Cross-Over Studies; Female; Humans; Ibuprofen; Kynurenic Acid; Kynurenine; Pilot Projects; Quinolinic Acid | 2022 |
Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
Topics: Child; Crohn Disease; Diet; Humans; Kynurenine; Melatonin; Prospective Studies; Quinolinic Acid; Remission Induction; Serotonin; Tryptophan | 2023 |
258 other study(ies) available for quinolinic acid and kynurenine
| Article | Year |
|---|---|
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1992 |
Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients.
Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; beta 2-Microglobulin; Biopterins; Blood-Brain Barrier; HIV-1; Humans; Kynurenine; Neopterin; Nervous System Physiological Phenomena; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Serotonin | 1992 |
Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome.
Topics: Adrenal Cortex Hormones; Adult; Aged; Eosinophilia-Myalgia Syndrome; Female; Humans; Interferon-gamma; Kynurenine; Male; Middle Aged; Quinolinic Acid; Scleroderma, Systemic; Tryptophan | 1992 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Macaca; Male; Middle Aged; Nervous System Diseases; Neuritis; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome | 1992 |
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1992 |
Neuroactive kynurenines in Lyme borreliosis.
Topics: Brain Diseases; Humans; Kynurenine; Lyme Disease; Lymphokines; Multiple Sclerosis; Nervous System Diseases; Quinolinic Acid; Quinolinic Acids | 1992 |
Alterations in tryptophan metabolism in the toxic oil syndrome and in the eosinophilia-myalgia syndrome.
Topics: Arthritis, Rheumatoid; Biopterins; Brassica; Eosinophilia-Myalgia Syndrome; Fatty Acids, Monounsaturated; Humans; Kynurenine; Neopterin; Plant Oils; Quinolinic Acid; Quinolinic Acids; Rapeseed Oil; Reference Values; Scleroderma, Systemic; Syndrome; Tryptophan | 1992 |
Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Dialysis; Drug Interactions; Hippocampus; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin; Veratridine | 1992 |
[The effect of kynurenine and quinolinic acid on autonomic and behavioral reactions in dogs].
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Conditioning, Classical; Dogs; Feeding Behavior; Hippocampus; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids | 1991 |
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates | 1991 |
Increased L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid concentrations in cerebral cortex following systemic endotoxin administration.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Kynurenine; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Quinolinic Acid; Quinolinic Acids; Serotonin; Stimulation, Chemical; Tryptophan | 1991 |
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Chronic effects of gamma-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice.
Topics: Animals; Brain; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Liver; Lung; Male; Mice; Mice, Inbred C57BL; Quinolinic Acid; Quinolinic Acids; Recombinant Proteins; Tryptophan Oxygenase | 1991 |
Stable isotope-labeled tryptophan as a precursor for studying the disposition of quinolinic acid in rabbits.
Topics: Animals; Deuterium; Half-Life; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rabbits; Tissue Distribution; Tryptophan | 1991 |
Indolic and kynurenine pathway metabolites of tryptophan in rat brain: effect of precursor availability on in vivo release.
Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Indoles; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1991 |
Production of quinolinic acid and kynurenic acid by human glioma.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Astrocytoma; Brain Neoplasms; Dioxygenases; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neoplasm Proteins; Oxygenases; Quinolinic Acid; Quinolinic Acids | 1991 |
Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and L-kynurenine in acute septicemia.
Topics: Acute Disease; Animals; Female; Kynurenic Acid; Kynurenine; Macaca mulatta; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Sepsis | 1990 |
Effect of catecholaminergic drugs on quinolinate- and kynurenine-induced seizures in mice.
Topics: Animals; Anticonvulsants; Catecholamines; Convulsants; Dopamine; Kynurenine; Male; Mice; Mice, Inbred Strains; Quinolinic Acid; Quinolinic Acids; Seizures; Sympathomimetics | 1990 |
[Comparative analysis of quinolinic acid and L-kynurenine action on the electrically controlled membrane ion channels of mollusk neurons].
Topics: Animals; Chemoreceptor Cells; Dose-Response Relationship, Drug; Drug Interactions; Electrophysiology; In Vitro Techniques; Kynurenine; Lymnaea; Neurons; Potassium Channels; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate | 1990 |
Systemic endotoxin increases L-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex.
Topics: Animals; Cerebral Cortex; Endotoxins; Hydroxyindoleacetic Acid; Injections, Intraperitoneal; Kynurenine; Mice; Mice, Inbred C57BL; Pyridines; Quinolinic Acid; Quinolinic Acids; Salmonella; Time Factors; Tryptophan | 1989 |
[Effects of antagonists of exciting amino acids on the neuro-destructive effect of quinolinic acid in vitro in comparison with their anticonvulsive action in situ].
Topics: Animals; Anticonvulsants; Cells, Cultured; Dicarboxylic Acids; Hippocampus; Imidazoles; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neurons; Pyridines; Quinolinic Acid; Quinolinic Acids | 1989 |
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Glutamic Acid; Grasshoppers; Kynurenine; Male; Membrane Potentials; Mice; Muscles; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures | 1986 |
Effect of kynurenine loading on quinolinic acid production in the rat: studies in vitro and in vivo.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Kynurenine; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Time Factors | 1988 |
The inhibitory effect of endogenous convulsants quinolinic acid and kynurenine on the pentobarbital stimulation of [3H]flunitrazepam binding.
Topics: Animals; Anticonvulsants; Flurazepam; Kinetics; Kynurenine; Male; Pentobarbital; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Convulsants; Drug Interactions; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Niacinamide; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1982 |
Convulsant action of intracerebroventricularly administered l-kynurenine sulphate, quinolinic acid and other derivatives of succinic acid, and effects of amino acids: structure-activity relationships.
Topics: Amino Acids; Animals; Anticonvulsants; Convulsants; Hydrogen-Ion Concentration; Injections, Intraventricular; Kynurenine; Male; Mice; Molecular Weight; Pyridines; Quinolinic Acid; Quinolinic Acids; Structure-Activity Relationship; Succinates | 1982 |
[Effect of anticonvulsants on convulsions induced by kynurenine, quinolinic acid, strychnine and corazole].
Topics: Animals; Anticonvulsants; Kynurenine; Mice; Pentylenetetrazole; Quinolinic Acid; Quinolinic Acids; Seizures | 1981 |
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Thinness; Tryptophan | 1995 |
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan | 1995 |
Metabolism of [5-3H]kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway.
Topics: Animals; Brain; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Osmolar Concentration; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Time Factors; Tritium | 1995 |
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.
Topics: Alanine; Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Extracellular Space; Hydrolases; Hypnotics and Sedatives; Kinetics; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Quinolinic Acid; Rats; Rats, Wistar | 1995 |
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates | 1995 |
6-Chloro-D,L-tryptophan, 4-chloro-3-hydroxyanthranilate and dexamethasone attenuate quinolinic acid accumulation in brain and blood following systemic immune activation.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Immune System; Kynurenine; Lung; Male; Mice; Mice, Inbred C57BL; Pokeweed Mitogens; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1994 |
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.
Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; Excitatory Amino Acid Antagonists; Hydrolases; Hypnotics and Sedatives; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neuroglia; Niacin; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
Kynurenine and probenecid prevent quinolinic acid-induced neurotoxicity in rat corpus striatum.
Topics: Animals; Brain Diseases; gamma-Aminobutyric Acid; Kynurenine; Male; Neostriatum; Probenecid; Quinolinic Acid; Rats; Rats, Wistar | 1994 |
Increased levels of the excitotoxin quinolinic acid in spinal cord following contusion injury.
Topics: Animals; Female; Guinea Pigs; Kynurenine; Macrophages; Neurotoxins; Quinolinic Acid; Reference Values; Somatosensory Cortex; Spinal Cord; Spinal Cord Compression; Spinal Cord Injuries; Tryptophan Oxygenase | 1993 |
Kynurenine pathway enzymes in brain: responses to ischemic brain injury versus systemic immune activation.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain; Carbon Isotopes; Dioxygenases; Female; Gerbillinae; Hydrolases; Ischemic Attack, Transient; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Lyases; Lymphocyte Activation; Mitochondria; Mixed Function Oxygenases; Organ Specificity; Oxygenases; Pokeweed Mitogens; Quinolinic Acid; Synaptosomes; Transaminases; Tryptophan; Tryptophan Oxygenase | 1993 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1993 |
Intravenous administration of L-kynurenine to rhesus monkeys: effect on quinolinate and kynurenate levels in serum and cerebrospinal fluid.
Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Kynurenic Acid; Kynurenine; Macaca mulatta; Quinolinic Acid; Time Factors | 1993 |
A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.
Topics: Animals; Duodenum; Female; Gerbillinae; Hydrocortisone; Immunization; Kidney; Kinetics; Kynurenine; Liver; Lung; ortho-Aminobenzoates; Pokeweed Mitogens; Quinolinic Acid; Spleen | 1993 |
Mechanism of delayed increases in kynurenine pathway metabolism in damaged brain regions following transient cerebral ischemia.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Female; Gerbillinae; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Ischemic Attack, Transient; Kynurenine; Macrophages; Pokeweed Mitogens; Quinolinic Acid; Time Factors; Tryptophan; Tryptophan Oxygenase | 1993 |
4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Carbolines; Cell Line; Harmine; Humans; Interferon-gamma; Kynurenine; Leukocytes, Mononuclear; Macrophages; Quinolinic Acid; Rats; Tryptophan; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.
Topics: 2-Aminoadipic Acid; Animals; Brain Diseases; Dialysis; Hippocampus; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Veratridine | 1995 |
Quinolinic acid in tumors, hemorrhage and bacterial infections of the central nervous system in children.
Topics: Adolescent; Adult; Bacterial Infections; Biomarkers; Biopterins; Central Nervous System Diseases; Central Nervous System Neoplasms; Cerebral Hemorrhage; Child; Child, Preschool; Female; Guanosine Triphosphate; Humans; Hydrocephalus; Infant; Infant, Newborn; Interleukin-6; Kynurenine; Male; Neopterin; Quinolinic Acid; Tryptophan Oxygenase; Tumor Necrosis Factor-alpha | 1995 |
Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice.
Topics: Animals; Brain; Enzyme Inhibitors; Indoles; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1996 |
Immunocytochemical localization of the endogenous neuroexcitotoxin quinolinate in human peripheral blood monocytes/macrophages and the effect of human T-cell lymphotropic virus type I infection.
Topics: Cells, Cultured; DNA, Viral; Human T-lymphotropic virus 1; Humans; Interferon-gamma; Kynurenine; Macrophages; Monocytes; Neuroimmunomodulation; Polymerase Chain Reaction; Proviruses; Quinolinic Acid; Tryptophan | 1996 |
Systemic DL-kynurenine and probenecid pretreatment attenuates quinolinic acid-induced neurotoxicity in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Kynurenine; Male; Motor Activity; Probenecid; Quinolinic Acid; Rats; Rats, Wistar | 1996 |
3-Hydroxykynurenine toxicity on the rat striatum in vivo.
Topics: Acetylcysteine; Animals; Brain Diseases; Corpus Striatum; Free Radical Scavengers; Injections, Intraventricular; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar | 1996 |
Increase of tryptophan in serum and in cerebrospinal fluid of patients with HIV infection during zidovudine therapy.
Topics: Anti-HIV Agents; Biopterins; Chromatography, High Pressure Liquid; HIV Infections; HIV Seropositivity; Humans; Kynurenine; Neopterin; Quinolinic Acid; Radioimmunoassay; Time Factors; Tryptophan; Zidovudine | 1996 |
Cytokine and drug modulation of kynurenine pathway metabolism by blood mononuclear cells.
Topics: Analysis of Variance; Carbon Isotopes; Cell Line; Dactinomycin; Dexamethasone; Humans; Hydrolases; Indomethacin; Interferon-gamma; Kinetics; Kynurenine; Kynurenine 3-Monooxygenase; Leukemia, Monocytic, Acute; Lipopolysaccharides; Macrophages; Mixed Function Oxygenases; Monocytes; Quinolinic Acid; Radioisotope Dilution Technique; Regression Analysis; Salmonella; Tritium; Tryptophan Oxygenase | 1996 |
Regulation of quinolinic acid in the normal rat brain by kynurenine pathway precursors.
Topics: 3-Hydroxyanthranilic Acid; Analysis of Variance; Animals; Cerebral Ventricles; Hippocampus; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stereoisomerism; Tryptophan | 1996 |
The kynurenines and the seizures.
Topics: Animals; Cerebral Ventricles; Electroencephalography; Hippocampus; Kynurenic Acid; Kynurenine; Microinjections; Neurons; ortho-Aminobenzoates; Penicillin G; Quinolinic Acid; Rats; Seizures | 1996 |
4-chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Dexamethasone; Female; Gerbillinae; Ischemic Attack, Transient; Kynurenine; Organ Specificity; Quinolinic Acid; Reference Values; Tryptophan Oxygenase | 1996 |
Kynurenine pathway metabolism in the galactosamine model of hepatic injury.
Topics: Animals; Brain; Female; Galactosamine; Gerbillinae; Hepatic Encephalopathy; Kynurenine; Lipopolysaccharides; Liver; Lung; Quinolinic Acid; Salmonella; Tryptophan Oxygenase | 1996 |
Increased quinolinate immunoreactivity in the peripheral blood monocytes/macrophages from SIV-infected monkeys.
Topics: Animals; Antibody Specificity; Cell Size; Cells, Cultured; Immunohistochemistry; Kynurenine; Macaca mulatta; Macrophages; Monocytes; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan | 1996 |
Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.
Topics: Astrocytes; Brain; Carbon Isotopes; Cells, Cultured; Fetus; Humans; Interferon-gamma; Isotope Labeling; Kynurenine; Macrophages; Microglia; Neurons; Neurotoxins; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1996 |
Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.
Topics: Alanine; Animals; Corpus Striatum; Dopamine; Drug Combinations; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neurons; Neurotoxins; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 1997 |
Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections.
Topics: Aging; Animals; Brain; Corpus Striatum; Functional Laterality; Glutamate Decarboxylase; Ibotenic Acid; Kynurenine; Male; Microinjections; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Time Factors; Tritium; Xanthurenates | 1997 |
Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.
Topics: Astrocytoma; B-Lymphocytes; Brain; Cell Line; Cells, Cultured; Fetus; Humans; Interferon-gamma; Kynurenine; Lipopolysaccharides; Liver; Lung; Macrophages; Monocytes; Quinolinic Acid; Tryptophan Oxygenase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1997 |
Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation.
Topics: Animals; Astrocytes; Brain Ischemia; Encephalitis; Gerbillinae; Immune System; Injections, Intraperitoneal; Kynurenine; Lipopolysaccharides; Microglia; Monocytes; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Species Specificity | 1997 |
Immuno-electron microscopy reveals that the excitotoxin quinolinate is associated with the plasma membrane in human peripheral blood monocytes/macrophages.
Topics: Cell Membrane; Humans; In Vitro Techniques; Interferon-gamma; Kynurenine; Macrophage Activation; Macrophages; Microscopy, Immunoelectron; Monocytes; Quinolinic Acid | 1997 |
Kynurenine pathway inhibition reduces neurotoxicity of HIV-1-infected macrophages.
Topics: Acquired Immunodeficiency Syndrome; Brain; Cell Aggregation; Cells, Cultured; Coloring Agents; Fetus; HIV-1; Humans; Immunohistochemistry; Kynurenine; L-Lactate Dehydrogenase; Macrophages; Microscopy, Electron; Quinolinic Acid; Trypan Blue; Tryptophan | 1997 |
Stimulation of NGF production by tryptophan and its metabolites in cultured mouse astroglial cells.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Kynurenine; Mice; Mice, Inbred C3H; Nerve Growth Factors; Quinolinic Acid; Serotonin; Tryptophan | 1997 |
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1998 |
Altered tryptophan metabolism in mice with herpes simplex virus encephalitis: increases in spinal cord quinolinic acid.
Topics: Animals; Brain; Encephalitis, Viral; Herpes Simplex; Herpesvirus 1, Human; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice; Mixed Function Oxygenases; Prosencephalon; Quinolinic Acid; Spinal Cord; Tryptophan; Tryptophan Oxygenase | 1998 |
Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells.
Topics: Animals; Astrocytes; Cells, Cultured; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Quinolinic Acid; RNA, Messenger; Serotonin; Tryptophan | 1998 |
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Huntington Disease; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; NADP; Neurons, Afferent; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques.
Topics: Acquired Immunodeficiency Syndrome; Animals; Brain; Central Nervous System; Cerebral Cortex; HIV-1; Humans; Kynurenine; Macaca; Quinolinic Acid; Retroviridae Infections | 1998 |
Differential effects of kynurenine and tryptophan treatment on quinolinate immunoreactivity in rat lymphoid and non-lymphoid organs.
Topics: Animals; Immunohistochemistry; Injections, Intraperitoneal; Kynurenine; Lymphoid Tissue; Male; NAD; Organ Specificity; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 1998 |
The analgesic effects of tryptophan and its metabolites in the rat.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates | 1998 |
Metabolic control of kynurenic acid formation in the rat brain.
Topics: Animals; Brain; Corpus Striatum; Electrophysiology; Energy Metabolism; Formazans; Kynurenic Acid; Kynurenine; Male; Potassium; Pyruvic Acid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Sodium; Substrate Specificity; Tetrazolium Salts; Veratridine | 1998 |
Effects of oxygen on 3-hydroxyanthranilate oxidase of the kynurenine pathway.
Topics: 3-Hydroxyanthranilic Acid; Animals; Brain; Enzyme Activation; Enzyme Inhibitors; Humans; Iron; Kinetics; Kynurenine; Liver; Oxidoreductases; Oxygen; Quinolinic Acid; Rats | 1998 |
Effects of mitochondria and o-methoxybenzoylalanine on 3-hydroxyanthranilic acid dioxygenase activity and quinolinic acid synthesis.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Alanine; Animals; Brain; Dioxygenases; Enzyme Inhibitors; Hydrolases; In Vitro Techniques; Kynurenine; Liver; Mice; Mitochondria; Mitochondria, Liver; N-Methylaspartate; Oxygenases; Quinolinic Acid | 1999 |
Quinolinic acid lesion of the nigrostriatal pathway: effect on turning behaviour and protection by elevation of endogenous kynurenic acid in Rattus norvegicus.
Topics: Alanine; Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neurons; Neuroprotective Agents; Niacin; Parkinson Disease, Secondary; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation | 1999 |
Quinolinic acid inhibits DOI-induced head shakes in mice.
Topics: 3-Hydroxyanthranilic Acid; Amphetamines; Animals; Dose-Response Relationship, Drug; Head Movements; Injections, Intraventricular; Injections, Subcutaneous; Kynurenine; Male; Mice; Quinolinic Acid; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reflex; Serotonin Receptor Agonists | 1999 |
3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Animals; Benzenesulfonates; Corpus Striatum; Drug Synergism; Electron Transport Complex IV; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Kynurenine; Male; Motor Activity; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1999 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
Kynurenine pathway metabolism in human astrocytes.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Astrocytes; Brain; Cells, Cultured; Dioxygenases; Fetus; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Oxygenases; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tryptophan Oxygenase | 1999 |
Role of kynurenines in the neurotoxic actions of kainic acid.
Topics: Alanine; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 2000 |
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.
Topics: 3-Hydroxyanthranilic Acid; Animals; Blood-Brain Barrier; Butyrates; Enzyme Inhibitors; Hippocampus; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis.
Topics: Astrocytes; Cells, Cultured; Fetus; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Kynurenic Acid; Kynurenine; Models, Biological; Neurotoxins; Quinolinic Acid; Tumor Necrosis Factor-alpha | 2000 |
Combined inhibition of indoleamine 2,3-dioxygenase and nitric oxide synthase modulates neurotoxin release by interferon-gamma-activated macrophages.
Topics: Animals; Cell Line; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Macrophage Activation; Macrophages; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Quinolinic Acid; Tryptophan Oxygenase | 2000 |
Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.
Topics: Adult; Albuminuria; Animals; Carboxy-Lyases; Enzyme Inhibitors; Female; Humans; Hydrolases; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Male; Middle Aged; Mixed Function Oxygenases; Pentosyltransferases; Pyrazinamide; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Tryptophan Oxygenase | 2000 |
Tryptophan metabolism through the kynurenine pathway in rat brain and liver slices.
Topics: Aerobiosis; Animals; Brain; In Vitro Techniques; Kynurenine; Liver; Male; NAD; Organ Specificity; Oxygen; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2000 |
Kynurenic acid influences the respiratory parameters of rat heart mitochondria.
Topics: Animals; Cell Respiration; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Kynurenine; Malates; Male; Mitochondria, Heart; Oxygen Consumption; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Similarities and differences in the neuronal death processes activated by 3OH-kynurenine and quinolinic acid.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Biomarkers; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Free Radical Scavengers; Glucosides; Immunohistochemistry; Kynurenine; L-Lactate Dehydrogenase; Mice; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Poly(ADP-ribose) Polymerase Inhibitors; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2001 |
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan | 2001 |
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection.
Topics: AIDS Dementia Complex; Astrocytes; Brain; Cells, Cultured; Cytokines; Enzymes; Fetus; Humans; Kynurenic Acid; Kynurenine; Models, Biological; Neurons; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction | 2001 |
Synthesis and release of neurotoxic kynurenine metabolites by human monocyte-derived macrophages.
Topics: Cell Death; Cells, Cultured; Culture Media, Conditioned; Cytokines; Encephalitis; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Humans; Hydrolases; Interferon-gamma; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Macrophages; Mixed Function Oxygenases; Monocytes; Neurons; Neurotoxins; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proteins; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Tryptophan; Tumor Necrosis Factor-alpha | 2001 |
Kynurenine and its metabolites in the rat with experimental renal insufficiency.
Topics: Animals; Drinking; Eating; Kidney Failure, Chronic; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan | 2001 |
IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; Humans; Interferon beta-1a; Interferon beta-1b; Interferon-beta; Interferon-gamma; Kinetics; Kynurenine; Macrophages; Models, Chemical; Multiple Sclerosis; Quinolinic Acid; RNA, Messenger | 2001 |
Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry.
Topics: Animals; Female; Fetus; Gas Chromatography-Mass Spectrometry; Humans; Kynurenine; Niacin; Niacinamide; Picolinic Acids; Quinolinic Acid; Sheep | 2002 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates | 2002 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates | 2001 |
Effects of systemic and central nervous system localized inflammation on the contributions of metabolic precursors to the L-kynurenine and quinolinic acid pools in brain.
Topics: Animals; Body Fluid Compartments; Brain; Corpus Striatum; Encephalitis; Female; Gerbillinae; Inflammation; Injections, Subcutaneous; Kidney; Kynurenine; Lipopolysaccharides; Liver; Lung; Mass Spectrometry; Models, Biological; Protein Binding; Quinolinic Acid; Serum Albumin; Tissue Distribution; Tritium; Tryptophan | 2002 |
T cell apoptosis by tryptophan catabolism.
Topics: 3-Hydroxyanthranilic Acid; Animals; Apoptosis; Autoimmune Diseases; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Nucleus; Cells, Cultured; Cytochrome c Group; Cytosol; Dose-Response Relationship, Drug; fas Receptor; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Microscopy, Electron; Mitochondria; Quinolinic Acid; Self Tolerance; T-Lymphocytes; Th1 Cells; Thymus Gland; Tryptophan | 2002 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles | 2002 |
3-Hydroxykynurenine-keto-C14: a precursor of urinary quinolinic acid.
Topics: Body Fluids; Humans; Kynurenine; Pyridines; Quinolinic Acid | 1961 |
Neurotoxic and neurobehavioral effects of kynurenines in adult insects.
Topics: Animals; Apoptosis; Behavior, Animal; Cell Survival; Cells, Cultured; Diptera; Dose-Response Relationship, Drug; Grasshoppers; Insecta; Kynurenine; Lethal Dose 50; Nervous System; Neurons; Neurotoxicity Syndromes; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2003 |
Expression of the kynurenine pathway enzymes in human microglia and macrophages.
Topics: Cells, Cultured; Gene Expression; Humans; Interferon-gamma; Kynurenine; Macrophages; Microglia; Quinolinic Acid; Recombinant Proteins; RNA, Messenger; Transaminases | 2003 |
3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease?
Topics: Aged; Animals; Butyrates; Case-Control Studies; Cerebellum; Corpus Striatum; Frontal Lobe; Humans; Huntington Disease; Kynurenine; Male; Middle Aged; Models, Neurological; Neostriatum; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2003 |
Changes in quinolinic acid production and its related enzymes following D-galactosamine and lipopolysaccharide-induced hepatic injury.
Topics: Animals; Carboxy-Lyases; Endotoxins; Galactosamine; Gerbillinae; Humans; Immunohistochemistry; Kynurenine; Lipopolysaccharides; Liver; Macrophages; Models, Chemical; Monocytes; Pyrogens; Quinolinic Acid; Time Factors; Tissue Distribution | 2004 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neurons; Phenotype; Pregnancy; Quinolinic Acid; Rats; Transaminases; Tryptophan | 2004 |
Expression of indoleamine 2,3-dioxygenase and production of quinolinic acid by human microglia, astrocytes, and neurons.
Topics: Astrocytes; Brain; Brain Chemistry; Cells, Cultured; Coculture Techniques; Encephalitis; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Macrophages; Mass Spectrometry; Microglia; Molecular Structure; Neurons; Quinolinic Acid; Signal Transduction; Tryptophan Oxygenase | 2005 |
Pharmacological manipulation of brain kynurenine metabolism.
Topics: Animals; Brain; Carbon Isotopes; Cytokines; Dose-Response Relationship, Drug; Drug Interactions; Humans; Inhibitory Concentration 50; Kynurenine; Light; Lipopolysaccharides; Macrophages; Male; Mice; Quinolinic Acid; Time Factors; Tritium | 2004 |
Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Hippocampus; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Microglia; Middle Aged; Neurons; Plaque, Amyloid; Quinolinic Acid; Tryptophan Oxygenase | 2005 |
Neuronal localization of indoleamine 2,3-dioxygenase in mice.
Topics: Animals; Encephalitis; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Microglia; Nerve Degeneration; Neurons; Quinolinic Acid; T-Lymphocytes; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured; Up-Regulation | 2005 |
Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease.
Topics: Animals; Brain Chemistry; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Knockout; Microinjections; Neostriatum; Neurons; Quinolinic Acid; Transaminases | 2006 |
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Topics: Age Factors; Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Mice; Mice, Transgenic; Quinolinic Acid | 2006 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Schedule; Embryo, Mammalian; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Metabolic Networks and Pathways; Mice; Parturition; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2007 |
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors | 2008 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2007 |
Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior, Animal; Cell Count; Coloring Agents; Cricetinae; Disease Models, Animal; Electroencephalography; Encephalitis, Viral; Hippocampus; Kynurenine; Measles virus; Mice; Mice, Inbred BALB C; Microglia; Monitoring, Physiologic; Nerve Degeneration; Neuroglia; Pyramidal Cells; Quinolinic Acid; Seizures; Tryptophan | 2008 |
Neurotoxic and neuroprotective metabolites of kynurenine in patients with renal cell carcinoma treated with interferon-alpha: course and relationship with psychiatric status.
Topics: Adult; Aged; Brain; Carcinoma, Renal Cell; Depressive Disorder, Major; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Immunologic Factors; Injections, Subcutaneous; Interferon-alpha; Kidney Neoplasms; Kynurenine; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Neurotoxins; Quinolinic Acid | 2008 |
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.
Topics: Animals; Brain; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Malaria, Cerebral; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Picolinic Acids; Quinolinic Acid; RNA, Messenger; Sulfonamides; Thiazoles; Tryptophan Oxygenase | 2009 |
NAD biosynthesis evolution in bacteria: lateral gene transfer of kynurenine pathway in Xanthomonadales and Flavobacteriales.
Topics: Bacteroidetes; Biosynthetic Pathways; Gene Transfer, Horizontal; Kynurenine; Phylogeny; Quinolinic Acid; Xanthomonas | 2009 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies; Diabetes Complications; Disease Progression; Female; Humans; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Logistic Models; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peritoneal Dialysis, Continuous Ambulatory; Peroxides; Quinolinic Acid; Renal Dialysis; Risk Assessment; Risk Factors; Superoxide Dismutase; Ultrasonography; Uremia | 2009 |
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Fluid; Functional Laterality; Kynurenic Acid; Kynurenine; Mice; Mice, Knockout; Microdialysis; Nerve Degeneration; Norbornanes; Quinolinic Acid; Transaminases; Tritium | 2009 |
Age and circadian influences on picolinic acid concentrations in human cerebrospinal fluid.
Topics: Aging; Analysis of Variance; C-Reactive Protein; Case-Control Studies; Central Nervous System Diseases; Circadian Rhythm; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Spinal Puncture; Statistics as Topic | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia | 2009 |
Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Hepatocytes; Kynurenine; Male; Niacinamide; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tritium; Tryptophan; Water | 2009 |
[Tryptophan and its metabolites in renal allograft recipients].
Topics: Adult; Aged; Creatinine; Female; Humans; Kidney Failure, Chronic; Kidney Transplantation; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Quinolinic Acid; Reference Values; Tryptophan; Urea | 2009 |
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
Topics: Adult; Antifibrinolytic Agents; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Fibrinolysin; Hemostasis; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Peptide Fragments; Peritoneal Dialysis, Continuous Ambulatory; Plasminogen Activator Inhibitor 1; Poland; Prevalence; Prothrombin; Quinolinic Acid; Receptors, Urokinase Plasminogen Activator; Thromboplastin; Tryptophan; Urokinase-Type Plasminogen Activator | 2010 |
CSF concentrations of brain tryptophan and kynurenines during immune stimulation with IFN-alpha: relationship to CNS immune responses and depression.
Topics: Adult; Antiviral Agents; Chemokine CCL2; Chromatography, High Pressure Liquid; Cytokines; Depression; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis C; Humans; Interferon-alpha; Kynurenine; Longitudinal Studies; Male; Middle Aged; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type II; Ribavirin; Statistics as Topic; Tryptophan | 2010 |
The kynurenine pathway and inflammation in amyotrophic lateral sclerosis.
Topics: Adult; Amyotrophic Lateral Sclerosis; Brain; Female; HLA-DR Antigens; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Quinolinic Acid; Signal Transduction; Spinal Cord; Tryptophan | 2010 |
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan | 2009 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2010 |
Human myeloid dendritic cells are refractory to tryptophan metabolites.
Topics: Antibodies; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Dendritic Cells; Flow Cytometry; Humans; Immunity, Cellular; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lymphocyte Activation; Macrophages; Membrane Glycoproteins; Monocytes; Quinolinic Acid; Receptors, Cell Surface; Receptors, Immunologic; T-Lymphocytes, Regulatory; Tryptophan | 2011 |
Changes in kynurenine pathway metabolism in the brain, liver and kidney of aged female Wistar rats.
Topics: Aging; Animals; Brain; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kidney; Kynurenine; Liver; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Signal Transduction; Transaminases; Tryptophan; Tryptophan Oxygenase | 2011 |
Tryptophan catabolism is associated with acute GVHD after human allogeneic stem cell transplantation and indicates activation of indoleamine 2,3-dioxygenase.
Topics: Adolescent; Adult; Aged; Chromatography, Liquid; Gene Expression Regulation, Enzymologic; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Intestines; Kynurenine; Mass Spectrometry; Middle Aged; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Time Factors; Transplantation, Homologous; Tryptophan; Young Adult | 2011 |
Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Biological Transport; Estrone; Humans; Kinetics; Kynurenic Acid; Kynurenine; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Quinolinic Acid; Xenopus laevis | 2012 |
Research on an in vitro cell system for testing the neurotoxicity of kynurenine pathway metabolites.
Topics: Brain Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Survival; Coloring Agents; Fluorescent Antibody Technique; Humans; Hydroxydopamines; Isoquinolines; Kynurenine; Neuroblastoma; Neurotoxins; Quinolinic Acid; Tetrazolium Salts; Thiazoles; Tretinoin | 2011 |
Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed by sub-chronic clozapine treatment.
Topics: Animals; Antipsychotic Agents; Clozapine; Kynurenine; Male; ortho-Aminobenzoates; Oxidative Stress; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Social Isolation; Tryptophan | 2012 |
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2012 |
Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
Topics: Animals; Drug Design; Humans; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid | 2012 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan | 2013 |
Connecting inflammation with glutamate agonism in suicidality.
Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Retrospective Studies; Somatosensory Disorders; Spinal Puncture; Suicide; Tritium; Young Adult | 2013 |
Secretion of quinolinic acid, an intermediate in the kynurenine pathway, for utilization in NAD+ biosynthesis in the yeast Saccharomyces cerevisiae.
Topics: Biosynthetic Pathways; Culture Media, Conditioned; Gene Expression; Gene Knockout Techniques; Genes, Fungal; Kynurenine; Membrane Transport Proteins; Microbial Viability; NAD; Pentosyltransferases; Quinolinic Acid; Saccharomyces cerevisiae; Transcription, Genetic | 2013 |
IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice.
Topics: Animals; Azoxymethane; beta Catenin; Carcinogens; Cell Proliferation; Colitis; Colitis, Ulcerative; Colonic Neoplasms; Epithelial Cells; HCT116 Cells; Homeodomain Proteins; HT29 Cells; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Kynurenine; Mice; Mice, Inbred C57BL; Mice, Knockout; Quinolinic Acid; Signal Transduction | 2013 |
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2013 |
Age-dependent alterations of the kynurenine pathway in the YAC128 mouse model of Huntington disease.
Topics: Aging; Animals; Brain; Cerebellum; Corpus Striatum; Female; Genotype; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan; Tryptophan Oxygenase | 2013 |
Systemic tryptophan and kynurenine catabolite levels relate to severity of rhinovirus-induced asthma exacerbation: a prospective study with a parallel-group design.
Topics: Adult; Asthma; Biomarkers; Breath Tests; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cytokines; Disease Progression; Eosinophil Cationic Protein; Eosinophils; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Nitric Oxide; ortho-Aminobenzoates; Peroxidase; Picornaviridae Infections; Prospective Studies; Quinolinic Acid; Rhinovirus; Tryptophan; Young Adult | 2013 |
Quinolinic acid: neurotoxin or oxidative stress modulator?
Topics: Hormesis; Humans; Hydrogen Peroxide; Inflammation; Iron; Kynurenine; Neurotoxins; Oxidative Stress; Quinolinic Acid; Reactive Oxygen Species | 2013 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan | 2014 |
Early modulation of the transcription factor Nrf2 in rodent striatal slices by quinolinic acid, a toxic metabolite of the kynurenine pathway.
Topics: Animals; Corpus Striatum; Female; Humans; Kynurenine; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar | 2014 |
Simultaneous detection of stable isotope-labeled and unlabeled L-tryptophan and of its main metabolites, L-kynurenine, serotonin and quinolinic acid, by gas chromatography/negative ion chemical ionization mass spectrometry.
Topics: Adult; Animals; Female; Gas Chromatography-Mass Spectrometry; Humans; Isotope Labeling; Kynurenine; Linear Models; Male; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reproducibility of Results; Serotonin; Tryptophan; Young Adult | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan | 2014 |
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan | 2015 |
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.
Topics: Adult; Cytokines; Depressive Disorder; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Suicidal Ideation; Suicide, Attempted; Young Adult | 2015 |
Bimodal plasma metabolomics strategy identifies novel inflammatory metabolites in inflammatory bowel diseases.
Topics: Adult; Angiotensin II; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Female; G(M3) Ganglioside; Histidine; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Kynurenine; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Middle Aged; Picolinic Acids; Pilot Projects; Quinolinic Acid; Tandem Mass Spectrometry; Young Adult | 2014 |
Involvement of the kynurenine pathway in human glioma pathophysiology.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Biosynthetic Pathways; Brain Neoplasms; Carboxy-Lyases; CD11b Antigen; Cells, Cultured; Chromatography, High Pressure Liquid; Disaccharides; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Glucuronates; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2014 |
Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.
Topics: Adult; Amygdala; Bipolar Disorder; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid | 2015 |
Quinolinic acid toxicity on oligodendroglial cells: relevance for multiple sclerosis and therapeutic strategies.
Topics: Animals; Antibodies, Monoclonal; Cell Line; Cell Line, Transformed; Encephalomyelitis, Autoimmune, Experimental; Kynurenine; Mice; Multiple Sclerosis; Oligodendroglia; Quinolinic Acid | 2014 |
Ongoing episode of major depressive disorder is not associated with elevated plasma levels of kynurenine pathway markers.
Topics: Adolescent; Adult; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Depressive Disorder, Major; Female; Humans; Interview, Psychological; Kynurenine; Male; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Signal Transduction; Treatment Outcome; Tryptophan; Young Adult | 2015 |
Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART.
Topics: Animals; Anti-Retroviral Agents; Brain; Enzyme-Linked Immunosorbent Assay; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Kynurenine; Macaca; Polymerase Chain Reaction; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome; Tryptophan | 2015 |
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans.
Topics: Adolescent; Adult; Aged; Biomarkers; Brain; Brain Injuries; Case-Control Studies; Female; Glasgow Outcome Scale; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Middle Aged; Neurotoxins; Prognosis; Quinolinic Acid; RNA, Messenger; Signal Transduction; Tryptophan; Young Adult | 2015 |
Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder.
Topics: Adult; Anhedonia; Biomarkers; Corpus Striatum; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Quinolinic Acid; Young Adult | 2015 |
The kynurenine pathway activities in a sub-Saharan HIV/AIDS population.
Topics: Acquired Immunodeficiency Syndrome; Adult; Africa South of the Sahara; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4 Lymphocyte Count; Cross-Sectional Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Gas Chromatography-Mass Spectrometry; HIV Infections; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-6; Kynurenine; Male; Middle Aged; Neopterin; Niacinamide; Pentosyltransferases; Poverty; Quinolinic Acid; South Africa; Tryptophan | 2015 |
Quinolinic Acid Responses during Interferon-α-Induced Depressive Symptomatology in Patients with Chronic Hepatitis C Infection - A Novel Aspect for Depression and Inflammatory Hypothesis.
Topics: Adult; Antiviral Agents; Depression; Female; Hepatitis C, Chronic; Humans; Interferon-alpha; Kynurenine; Male; Middle Aged; Prospective Studies; Psychiatric Status Rating Scales; Quinolinic Acid | 2015 |
Smaller Dentate Gyrus and CA2 and CA3 Volumes Are Associated with Kynurenine Metabolites in Collegiate Football Athletes.
Topics: Adolescent; Adult; Athletes; Athletic Injuries; Brain Concussion; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Dentate Gyrus; Football; Humans; Kynurenine; Magnetic Resonance Imaging; Male; Quinolinic Acid; Universities; Young Adult | 2016 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan | 2016 |
Evaluation of the antioxidant properties of tryptophan and its metabolites in in vitro assay.
Topics: Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Cell Proliferation; Enzyme-Linked Immunosorbent Assay; Growth Inhibitors; Humans; Interferon-gamma; Interleukin-6; Kynurenine; Melatonin; Milk, Human; Neuroglia; ortho-Aminobenzoates; Oxygen Radical Absorbance Capacity; Quinolinic Acid; Recombinant Proteins; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult | 2016 |
Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats.
Topics: Animals; Brain; Corticosterone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Limbic System; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stress, Psychological; Up-Regulation | 2016 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2015 |
Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression.
Topics: Adult; Depressive Disorder, Major; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Memory, Episodic; Mental Recall; Middle Aged; Quinolinic Acid; Young Adult | 2016 |
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates | 2015 |
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.
Topics: Animals; Brain; Immune System; Inflammation; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Quinolinic Acid | 2016 |
Female Flinders Sensitive Line rats show estrous cycle-independent depression-like behavior and altered tryptophan metabolism.
Topics: 5-Hydroxytryptophan; Animals; Anxiety; Brain; Depressive Disorder; Disease Models, Animal; Estrous Cycle; Female; Kynurenine; Male; Motor Activity; ortho-Aminobenzoates; Quinolinic Acid; Rats; Resilience, Psychological; Sex Characteristics; Tryptophan | 2016 |
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan | 2016 |
Post-Bariatric Surgery Changes in Quinolinic and Xanthurenic Acid Concentrations Are Associated with Glucose Homeostasis.
Topics: Adult; Bariatric Surgery; C-Reactive Protein; Diabetes Mellitus; Female; Glucose; Homeostasis; Humans; Kynurenine; Metabolome; Quinolinic Acid; Serotonin; Tryptophan; Xanthurenates | 2016 |
An enzyme in the kynurenine pathway that governs vulnerability to suicidal behavior by regulating excitotoxicity and neuroinflammation.
Topics: Adolescent; Adult; Aged; Alleles; Carboxy-Lyases; Case-Control Studies; Child; Female; Humans; Inflammation; Kynurenine; Male; Middle Aged; Picolinic Acids; Polymorphism, Single Nucleotide; Quinolinic Acid; Self-Injurious Behavior; Suicidal Ideation; Suicide, Attempted; Young Adult | 2016 |
LC-MS/MS-based quantification of kynurenine metabolites, tryptophan, monoamines and neopterin in plasma, cerebrospinal fluid and brain.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Humans; Kynurenine; Mice, Inbred C57BL; Neopterin; ortho-Aminobenzoates; Quinolinic Acid; Signal Transduction; Tandem Mass Spectrometry; Tryptophan | 2016 |
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
Topics: Flagellin; Gene Expression Regulation; Humans; Hydrolysis; Imidazoles; Kynurenic Acid; Kynurenine; Lipopeptides; Lipopolysaccharides; Listeria monocytogenes; Monocytes; Poly I-C; Primary Cell Culture; Protein Isoforms; Quinolinic Acid; Signal Transduction; Toll-Like Receptors; Tryptophan | 2016 |
Abnormalities in Functional Connectivity in Collegiate Football Athletes with and without a Concussion History: Implications and Role of Neuroactive Kynurenine Pathway Metabolites.
Topics: Adult; Athletic Injuries; Brain Concussion; Cerebral Cortex; Connectome; Football; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Students; Universities; Young Adult | 2017 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2017 |
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production.
Topics: Animals; Borna Disease; Borna disease virus; Brain; Cell Line; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Host-Pathogen Interactions; Kynurenine; Metabolic Networks and Pathways; Quinolinic Acid; Rats | 2017 |
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Depressive Disorder, Major; Female; GABAergic Neurons; Humans; Inflammation; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Psychotic Disorders; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
Sleep disturbance and kynurenine metabolism in depression.
Topics: Adult; Depression; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Sleep Wake Disorders | 2017 |
Major Depression as a Neuroprogressive Prelude to Dementia: What Is the Evidence?
Topics: Brain; Cytokines; Dementia; Depressive Disorder, Major; Humans; Inflammation; Kynurenine; Oxidative Stress; Quinolinic Acid; Tryptophan | 2017 |
Kynurenine Pathway Metabolites in Alzheimer's Disease.
Topics: 3-Hydroxyanthranilic Acid; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cognition Disorders; Cohort Studies; Female; Humans; Kynurenine; Male; Middle Aged; Neuropsychological Tests; Quinolinic Acid; Signal Transduction; Statistics, Nonparametric; Tryptophan; Xanthurenates | 2017 |
Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects.
Topics: Aged; Animals; Brain; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fluoroquinolones; Glucose; Glutamine; Humans; In Vitro Techniques; Kynurenine; Male; Mice; Middle Aged; Piperazines; Postmortem Changes; Pyruvic Acid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tacrolimus; Temperature; Tissue Distribution; Transaminases; Veratridine; Xanthurenates | 2017 |
Proposed biochemistry of Parkinson's and Alzheimer's diseases.
Topics: Aldehydes; Alzheimer Disease; Aspartic Acid; Betaine; Brain; Disease Progression; Humans; Kynurenine; Lewy Bodies; Models, Biological; Parkinson Disease; Plaque, Amyloid; Pyruvaldehyde; Quinolinic Acid; Treatment Outcome | 2017 |
Effects of high ambient temperature on plasma metabolomic profiles in chicks.
Topics: Amino Acids, Sulfur; Animals; Chickens; Cystathionine; Cysteine; Cystine; Environmental Exposure; Gas Chromatography-Mass Spectrometry; Homocysteine; Hot Temperature; Kynurenine; Molecular Weight; Niacinamide; Oxidative Stress; Quinolinic Acid; Taurine; Tryptophan | 2018 |
Regulation of the kynurenine metabolism pathway by Xiaoyao San and the underlying effect in the hippocampus of the depressed rat.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP Response Element-Binding Protein; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Hippocampus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Kynurenine 3-Monooxygenase; Locomotion; Male; Neural Cell Adhesion Molecules; Quinolinic Acid; Rats, Sprague-Dawley; Signal Transduction; Tryptophan | 2018 |
A validated liquid chromatography-high resolution-tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Kynurenic Acid; Kynurenine; Limit of Detection; Metabolome; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2017 |
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan | 2019 |
Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.
Topics: Animals; Brain; Cell Line; Homeostasis; Hypothalamo-Hypophyseal System; Inflammation; Interleukin-1beta; Interleukin-6; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Microglia; Mixed Function Oxygenases; Neuroimmunomodulation; Neurons; Nitric Oxide Synthase Type II; Pituitary-Adrenal System; Quinolinic Acid; Tumor Necrosis Factor-alpha | 2018 |
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.
Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Cognition Disorders; Executive Function; Female; Humans; Immunoglobulin A; Immunoglobulin M; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Neuropsychological Tests; Picolinic Acids; Psychiatric Status Rating Scales; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Xanthurenates; Young Adult | 2018 |
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Child; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2018 |
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan | 2018 |
Can IDO activity predict primary resistance to anti-PD-1 treatment in NSCLC?
Topics: Aged; Carcinoma, Non-Small-Cell Lung; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Immunotherapy; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kaplan-Meier Estimate; Kynurenine; Lung Neoplasms; Male; Multivariate Analysis; Programmed Cell Death 1 Receptor; Quinolinic Acid; Tryptophan | 2018 |
[Correlation between kynurenine metabolites and postpartum depression].
Topics: Biomarkers; Cesarean Section; China; Depression, Postpartum; Female; Humans; Incidence; Kynurenic Acid; Kynurenine; Pregnancy; Quinolinic Acid | 2018 |
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Mice, Knockout; Placenta; Pregnancy; Quinolinic Acid; Schizophrenia | 2018 |
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan | 2019 |
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age.
Topics: Aged; Aged, 80 and over; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Quinolinic Acid; Tryptophan | 2018 |
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; NAD; Neurons; Oxidative Stress; Primary Cell Culture; Quinolinic Acid; Reactive Oxygen Species | 2019 |
Indoleamine 2,3-Dioxygenase-Dependent Neurotoxic Kynurenine Metabolism Contributes to Poststroke Depression Induced in Mice by Ischemic Stroke along with Spatial Restraint Stress.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Brain Ischemia; Depressive Disorder; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Male; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes; Quinolinic Acid; Reactive Oxygen Species; Restraint, Physical; Spatial Learning; Stress, Psychological; Stroke | 2018 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult | 2019 |
Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Hydroxyindoleacetic Acid; Kynurenine; Male; Neurotransmitter Agents; Plasma; Quinolinic Acid; Rats; Rats, Wistar; Serotonin; Tandem Mass Spectrometry; Toxoplasmosis; Tryptophan | 2019 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio | 2020 |
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates | 2020 |
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors.
Topics: Animals; Biosynthetic Pathways; Cell Line; Chromosomes, Human, Pair 21; Cytokines; Down Syndrome; Gene Expression; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metabolomics; Mice, Inbred C57BL; Quinolinic Acid; Receptors, Interferon; Trisomy | 2019 |
Pyridine-2,3-dicarboxylate, quinolinic acid, induces 1N4R Tau amyloid aggregation in vitro: Another evidence for the detrimental effect of the inescapable endogenous neurotoxin.
Topics: Alzheimer Disease; Amyloid; Humans; Kynurenine; Neurotoxins; Protein Aggregates; Pyridines; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2020 |
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.
Topics: Adult; Alleles; Cesarean Section; Depression, Postpartum; Female; Genotype; Humans; Kynurenic Acid; Kynurenine; Polymorphism, Single Nucleotide; Pregnancy; Quinolinic Acid; Transaminases | 2020 |
Quinolinate as a Marker for Kynurenine Metabolite Formation and the Unresolved Question of NAD
Topics: Animals; Biomarkers; Cell Movement; Gerbillinae; Hippocampus; HSP90 Heat-Shock Proteins; Immunity; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; NAD; Pokeweed Mitogens; Poly(ADP-ribose) Polymerases; Quinolinic Acid; Rats; Spleen; Tryptophan | 2020 |
Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome.
Topics: Diarrhea; Female; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2020 |
The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder.
Topics: Adolescent; Cross-Sectional Studies; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2021 |
Involvement of Indoleamine-2,3-Dioxygenase and Kynurenine Pathway in Experimental Autoimmune Encephalomyelitis in Mice.
Topics: Animals; Body Weight; Cytokines; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Gene Expression; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Kynurenine 3-Monooxygenase; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Oximes; Peptide Fragments; Quinolinic Acid; Sulfonamides; Tryptophan | 2020 |
Kynurenic Acid Protects Against Reactive Glial-associated Reductions in the Complexity of Primary Cortical Neurons.
Topics: Animals; Kynurenic Acid; Kynurenine; Neuroglia; Neurons; Quinolinic Acid; Rats | 2021 |
Alterations in the Kynurenine Pathway of Tryptophan Metabolism Are Associated With Depression in People Living With HIV.
Topics: Antidepressive Agents; Comorbidity; Depression; Female; HIV Infections; Humans; Kynurenine; Male; Middle Aged; Psychometrics; Quinolinic Acid; Tryptophan | 2021 |
Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.
Topics: Humans; Kynurenic Acid; Kynurenine; Memory, Short-Term; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.
Topics: Adult; Case-Control Studies; Cognition; Cognitive Dysfunction; Depressive Disorder, Major; Female; Humans; Kynurenine; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Tryptophan; Young Adult | 2021 |
Capillary electrochromatography-mass spectrometry of kynurenine pathway metabolites.
Topics: Alkanesulfonic Acids; Buffers; Calibration; Capillary Electrochromatography; Electricity; Humans; Hydrogen-Ion Concentration; Kynurenine; Limit of Detection; Linear Models; Metabolic Networks and Pathways; Metabolome; Pressure; Quinolinic Acid; Reference Standards; Reproducibility of Results; Tandem Mass Spectrometry | 2021 |
Caenorhabditis elegans as a model for studies on quinolinic acid-induced NMDAR-dependent glutamatergic disorders.
Topics: 1-Octanol; Adenosine Triphosphate; Amino Acid Metabolism, Inborn Errors; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Citrate (si)-Synthase; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Motor Activity; Neurodegenerative Diseases; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission | 2021 |
Tryptophan, kynurenine pathway, and diabetic ketoacidosis in type 1 diabetes.
Topics: Adolescent; Child; Chromatography, Liquid; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Glucose; Humans; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2021 |
A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.
Topics: Animals; Female; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice; Placenta; Pregnancy; Quinolinic Acid | 2021 |
Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms.
Topics: Alcoholism; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2021 |
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Topics: Biomarkers; Depressive Disorder, Major; Heart Rate; Humans; Kynurenine; Quinolinic Acid; Reproducibility of Results; Sensitivity and Specificity; Stress, Physiological; Tryptophan | 2021 |
Quinolinic acid, a kynurenine/tryptophan pathway metabolite, associates with impaired cognitive test performance in systemic lupus erythematosus.
Topics: Cognitive Dysfunction; Cross-Sectional Studies; Humans; Kynurenine; Lupus Erythematosus, Systemic; Neuropsychological Tests; Quinolinic Acid; Tryptophan | 2021 |
Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
Topics: 3-Hydroxyanthranilic Acid; Adult; Aged; Apoptosis; Autopsy; Brain; COVID-19; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Lung; Middle Aged; Myocardium; Prospective Studies; Quinolinic Acid; Severity of Illness Index; Tryptophan | 2022 |
Alterations in Kynurenine and NAD
Topics: Colitis; Humans; Inflammatory Bowel Diseases; Infliximab; Kynurenine; Metabolic Networks and Pathways; Nicotinamide N-Methyltransferase; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, Nicotinic; Tryptophan | 2021 |
Peripheral and central kynurenine pathway abnormalities in major depression.
Topics: Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2022 |
Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
Topics: Adult; Aged; COVID-19; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Picolinic Acids; Prognosis; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2022 |
The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.
Topics: Adiposity; Adult; Birth Weight; Cesarean Section; Child; Child, Preschool; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; Longitudinal Studies; Pediatric Obesity; Pregnancy; Prospective Studies; Quinolinic Acid | 2022 |
Association of plasma kynurenine pathway metabolite concentrations with metabolic health risk in prepubertal Asian children.
Topics: Child; Cohort Studies; Fatty Liver; Humans; Kynurenine; Metabolic Syndrome; Overweight; Pediatric Obesity; Prospective Studies; Quinolinic Acid; Triglycerides | 2022 |
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Interferon Regulatory Factor-3; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Quinolinic Acid; Virus Diseases | 2022 |
Alteration in cerebral blood flow, kynurenines with respect to mood profile in freshly recruited armed forces personnel.
Topics: Animals; Cerebrovascular Circulation; Female; Geese; Humans; Kynurenine; Male; Military Personnel; Quinolinic Acid | 2022 |
Topics: Animals; Autistic Disorder; Bifidobacterium longum; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Kynurenine; Neuroinflammatory Diseases; Neurotransmitter Agents; Quinolinic Acid; Rats | 2022 |
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
Topics: Behcet Syndrome; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
Topics: Cross-Sectional Studies; Female; Humans; Kynurenic Acid; Kynurenine; Polycystic Ovary Syndrome; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
Kynurenine monooxygenase inhibition and associated reduced quinolinic acid reverses depression-like behaviour by upregulating Nrf2/ARE pathway in mouse model of depression: In-vivo and In-silico studies.
Topics: Animals; Antioxidants; Depression; Depressive Disorder, Major; Disease Models, Animal; Humans; Kelch-Like ECH-Associated Protein 1; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Molecular Docking Simulation; NF-E2-Related Factor 2; Phosphatidylinositol 3-Kinases; Proteasome Endopeptidase Complex; Quinolinic Acid; RNA, Messenger | 2022 |
C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder.
Topics: C-Reactive Protein; Depressive Disorder, Major; Diffusion Tensor Imaging; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Sexually Transmitted Diseases; White Matter | 2022 |
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.
Topics: Animals; Endothelial Cells; Humans; Hypoxia; Interleukin-6; Kynurenic Acid; Kynurenine; Monocrotaline; Pulmonary Arterial Hypertension; Quinolinic Acid; Rats; Receptors, Interleukin-6 | 2022 |
Involvement of kynurenine pathway and N-methyl-d-aspartate receptors in the antidepressant-like effect of vilazodone in the tail suspension test in mice.
Topics: Animals; Antidepressive Agents; Depression; Hindlimb Suspension; Ketamine; Kynurenine; Mice; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Swimming; Vilazodone Hydrochloride | 2022 |
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Neopterin; Quinolinic Acid; Substance Withdrawal Syndrome; Tryptophan | 2022 |
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Lymnaea; Quinolinic Acid; Tryptophan | 2022 |
Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine.
Topics: Animals; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Phencyclidine; Prepulse Inhibition; Quinolinic Acid; RNA, Messenger | 2022 |
2-month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice.
Topics: Animals; Cognition; Diet, Ketogenic; Female; Kynurenic Acid; Kynurenine; Male; Mice; Muscle, Skeletal; Neurotoxins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Quinolinic Acid | 2022 |
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan | 2022 |
Anti-inflammatory effects of ellagic acid and vanillic acid against quinolinic acid-induced rat model of Huntington's disease by targeting IKK-NF-κB pathway.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Caspase 3; Ellagic Acid; Huntington Disease; Interleukin-6; Kynurenine; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Tumor Necrosis Factor-alpha; Vanillic Acid | 2022 |
Meningeal dendritic cells drive neuropathic pain through elevation of the kynurenine metabolic pathway in mice.
Topics: Animals; Dendritic Cells; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenine; Metabolic Networks and Pathways; Mice; Neuralgia; Quinolinic Acid | 2022 |
Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.
Topics: Aged; Aging; Child, Preschool; Frailty; Humans; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE.
Topics: Cognitive Dysfunction; Humans; Interferons; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Quinolinic Acid; Tryptophan | 2022 |
Cerebrospinal fluid quinolinic acid is strongly associated with delirium and mortality in hip-fracture patients.
Topics: Acute Disease; Delirium; Hip Fractures; Humans; Inflammation; Kynurenine; Quinolinic Acid | 2023 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic Acid; Kynurenine; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
CSF neopterin, quinolinic acid and kynurenine/tryptophan ratio are biomarkers of active neuroinflammation.
Topics: Adolescent; Biomarkers; Child; Child, Preschool; Humans; Infant; Inflammation; Kynurenine; Leukocytosis; Male; Neopterin; Nervous System Diseases; Neuroinflammatory Diseases; Quinolinic Acid; Tryptophan | 2023 |
CSF neopterin and quinolinic acid are biomarkers of neuroinflammation and neurotoxicity in FIRES and other infection-triggered encephalopathy syndromes.
Topics: Biomarkers; Brain Diseases; Chromatography, Liquid; Encephalitis; Humans; Kynurenine; Neopterin; Neuroinflammatory Diseases; Quinolinic Acid; Seizures; Status Epilepticus; Syndrome; Tandem Mass Spectrometry | 2023 |
Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice.
Topics: Adolescent; Animals; Coleoptera; Depression; Gastrointestinal Microbiome; Humans; Kynurenine; Metabolomics; Mice; Microbiota; Quinolinic Acid; Serotonin; Sertraline; Tryptophan | 2023 |
Relationship of tryptophan metabolites with the type and severity of multiple sclerosis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Mammals; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2023 |
The possible role of quinolinic acid as a predictive marker in patients with SARS-CoV-2.
Topics: C-Reactive Protein; COVID-19; Humans; Kynurenine; Procalcitonin; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2023 |
Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Child; Child, Preschool; Humans; Infant; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2023 |