quinolinic acid has been researched along with kynurenic acid in 223 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (10.31) | 18.7374 |
| 1990's | 50 (22.42) | 18.2507 |
| 2000's | 43 (19.28) | 29.6817 |
| 2010's | 65 (29.15) | 24.3611 |
| 2020's | 42 (18.83) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Pewnim, T; Seifert, J | 1 |
| Furukawa, H; Hasegawa, T; Maeda, Y; Nabeshima, T; Nakamura, T | 1 |
| Alesiani, M; Ciuffi, M; Facci, L; Fadda, E; Galli, A; Lombardi, G; Mori, F; Moroni, F; Natalini, B; Skaper, SD | 1 |
| Schwab, F; Vécsei, L | 1 |
| Crowley, JS; Davis, LE; Demitrack, MA; Der, M; Dilling, LA; Elia, J; Heyes, MP; Kruesi, MJ; Lackner, A; Saito, K | 1 |
| Heyes, MP; Markey, SP; Saito, K | 1 |
| Beninger, RJ; Boegman, RJ; Cockhill, J; Jhamandas, K | 1 |
| Frank, JA; Gravell, M; Heyes, MP; Jordan, EK; Lee, K; Markey, SP; Saito, K; Snoy, PJ | 1 |
| Schwarcz, R; Ungerstedt, U; Wu, HQ | 2 |
| Carlà, V; De Luca, G; Moroni, F; Politi, V; Russi, P | 1 |
| Connick, JH; Stone, TW | 1 |
| Morgan, PF | 1 |
| Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P | 1 |
| Du, F; Schwarcz, R | 1 |
| Rios, C; Santamaria, A | 1 |
| Fukui, S; Rapoport, SI; Schwarcz, R; Smith, QR; Takada, Y | 1 |
| Gallo-Mezo, MA; Moneti, G; Moroni, F; Pellicciari, R; Russi, P | 1 |
| During, MJ; Freese, A; Heyes, MP; Markey, SP; Martin, JB; Matson, WR; Roth, RH; Swartz, KJ | 1 |
| Gramsbergen, JB; Schwarcz, R; Speciale, C; Vezzani, A | 1 |
| April, M; Blackmore, D; Eckhaus, M; Gravell, M; Heyes, MP; London, WT; Markey, SP; Vickers, JH; Yergey, JA | 1 |
| Keilhoff, G; Schmidt, W; Stastný, F; Wolf, G | 1 |
| Heyes, MP; Lackner, A | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K | 1 |
| Beninger, RJ; Bialik, M; Boegman, RJ; Jhamandas, K | 1 |
| Allix, M; Boulu, RG; Lekieffre, D; Plotkine, M | 1 |
| Dedhia, M; Heyes, MP; Lackner, A; Mefford, IN; Quearry, BJ | 1 |
| Beninger, RJ; Bialik, M; Boegman, RJ; Jhamandas, K; Wirsching, BA | 1 |
| McGeer, EG; McGeer, PL; Zhu, SG | 1 |
| Khaspekov, LG; Lapin, IP; Ryzhov, IV; Viktorov, IV | 1 |
| Schwarcz, R; Speciale, C; Ungerstedt, U | 1 |
| Meguri, H; Ogita, K; Ohgaki, T; Uchida, S; Yoneda, Y | 1 |
| Cotman, CW; Ganong, AH | 1 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 1 |
| Burton, NR; Smith, DA; Stone, TW | 1 |
| Burton, NR; Smith, DA; Stone, TW; Williams, TL | 1 |
| Beninger, RJ; Boegman, RJ; el-Defrawy, SR; Jhamandas, K; Ludwin, SK | 1 |
| Beninger, RJ; Boegman, RJ; el-Defrawy, SR; Jhamandas, K | 2 |
| Kiseleva, IP; Lapin, IP; Prakhie, IB | 1 |
| Hankins, MW; Ruddock, KH | 1 |
| French, ED; Schwarcz, R; Vezzani, A; Whetsell, WO | 1 |
| Choi, DW; Kim, JP | 1 |
| Perkins, MN; Stone, TW | 4 |
| Shibata, Y; Takeuchi, F; Tsubouchi, R | 1 |
| Foster, AC | 1 |
| Foster, AC; French, ED; Schwarcz, R; Vezzani, A | 1 |
| Altemus, M; Demitrack, MA; Gold, PW; Heyes, MP; Pigott, TA | 1 |
| Chen, CY; Heyes, MP; Markey, SP; Naritsin, DB; Saito, K | 1 |
| Carpenedo, R; Chiarugi, A; Mattoli, L; Molina, MT; Moroni, F; Pellicciari, R | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Boni, RL; Markey, SP; Naritsin, DB | 1 |
| Carlà, V; Carpenedo, R; Chiarugi, A; Lombardi, G; Mattoli, L; Moroni, F; Pellicciari, R; Russi, P | 1 |
| Heyes, MP; Major, EO; Markey, SP; Milstien, S; Saito, K; Vickers, JH | 1 |
| Chase, TN; Jauch, DA; Schwarcz, R; Sethy, VH; Weick, BG | 1 |
| Schwarcz, R | 1 |
| Heyes, MP | 1 |
| Beninger, RJ; Boegman, RJ; Flesher, S; Jhamandas, KH; Pawley, AC | 1 |
| Behan, WM; Graham, DI; Jones, P; MacGregor, DG; Smith, RA; Stone, TW | 1 |
| Guzeva, VI; Melnikova, NV; Mikhailov, IB | 1 |
| Salituro, FG; Schwarcz, R; Wu, HQ | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF | 1 |
| Dong-Ruyl, L; Nakano, K; Sawada, M | 1 |
| Beninger, RJ; Boegman, RJ; Harris, CA; Jhamandas, K; Miranda, AF; Tanguay, JJ | 1 |
| Goodman, CB; Heyliger, SO; Ngong, JM; Soliman, KF | 1 |
| Hodgkins, PS; Schwarcz, R | 1 |
| Beninger, RJ; Boegman, RJ; Jhamandas, K; Miranda, AF; Sutton, MA | 1 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Ceresoli-Borroni, G; Guidetti, P; Schwarcz, R | 1 |
| Fornstedt-Wallin, B; Fredriksson, G; Lundström, J; Luthman, J; Schwarcz, R | 1 |
| Lee, SC; Schwarcz, R; Wu, HQ | 1 |
| Guidetti, P; Schwarcz, R; Wu, HQ | 1 |
| Ceresoli-Borroni, G; Goodman, JH; Guidetti, P; Scharfman, HE; Schwarcz, R; Speciale, C; Varasi, M; Wu, HQ | 1 |
| Obrenovitch, TP; Urenjak, J | 2 |
| Armati, PJ; Brew, BJ; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA | 1 |
| Arun, P; Deepadevi, KV; Kurup, PA; Manojkumar, V; Ravikumar, A | 1 |
| Baran, H; Gille, L; Kepplinger, B; Nohl, H; Staniek, K; Stolze, K | 1 |
| Lacey, B; Nicholls, T; Nitsos, I; Smythe, G; Walker, DW | 1 |
| Stone, TW | 1 |
| Lee, SC; Schwarcz, R | 1 |
| Baraldi, M; Cannazza, G; Chiarugi, A; Parenti, C; Zanoli, P | 1 |
| Armati, PJ; Brew, BJ; Croitoru, J; Guillemin, GJ; Kapoor, V; Kerr, SJ; Smith, DG; Smythe, GA | 1 |
| Nicholls, T; Nitsos, I; Smythe, G; Walker, DW | 1 |
| Fukuwatari, T; Hayakawa, F; Morikawa, Y; Shibata, K; Sugimoto, E | 1 |
| Buczko, W; Mysliwiec, P; Pawlak, D; Tankiewicz, A | 1 |
| Rassoulpour, A; Schwarcz, R; Wu, HQ | 1 |
| Buczko, W; Malyszko, J; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Pellicciari, R; Schwarcz, R | 1 |
| Carpenedo, R; Meli, E; Moroni, F; Pellegrini-Giampietro, DE; Peruginelli, F | 1 |
| Fuxe, K; Schwarcz, R; Wu, HQ | 1 |
| Cai, T; Chen, A; Di Prospero, NA; Du, F; Guidetti, P; Melendez-Ferro, M; Sapko, MT; Schwarcz, R; Tagle, DA; Whetsell, WO; Yu, P | 1 |
| Rho, JM | 1 |
| Augood, SJ; Guidetti, P; Luthi-Carter, RE; Schwarcz, R | 1 |
| Bédard, PJ; Grégoire, L; Guidetti, P; Izzo, E; Rassoulpour, A; Samadi, P; Schwarcz, R | 1 |
| Guidetti, P; Pellicciari, R; Sapko, MT; Schwarcz, R; Tagle, DA; Yu, P | 1 |
| Bari, F; Busija, DW; Domoki, F; Guidetti, P; Nagy, K; Schwarcz, R | 1 |
| Angeli, I; Cozzi, A; Di Serio, C; Doria, L; Masotti, G; Micucci, I; Mirone, P; Moroni, F; Pellerito, S; Tarantini, F | 1 |
| Bates, GP; Graham, RK; Guidetti, P; Hayden, MR; Leavitt, BR; MacDonald, ME; Schwarcz, R; Slow, EJ; Wheeler, VC; Woodman, B | 1 |
| Blight, AR; Heyes, MP; Yates, JR | 1 |
| Perez-De La Cruz, V; Santamaria, A | 1 |
| Amori, L; Ceresoli-Borroni, G; Guidetti, P; Pellicciari, R; Schwarcz, R | 1 |
| Guidetti, P; Poeggeler, B; Rassoulpour, A; Roberts, RC; Schwarcz, R; Wu, HQ | 1 |
| Bédard, PJ; Di Paolo, T; Grégoire, L; Guidetti, P; Izzo, E; Rassoulpour, A; Samadi, P; Schwarcz, R | 1 |
| Bosmans, E; Kubera, M; Maes, M; Mihaylova, I; Ruyter, MD | 1 |
| Fukuwatari, T; Shibata, K | 2 |
| Ball, HJ; Hunt, NH; Mellor, AL; Miu, J | 1 |
| Brzosko, S; Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Amori, L; Guidetti, P; Marinozzi, M; Pellicciari, R; Schwarcz, R; Wu, HQ | 1 |
| Fotopoulou, C; Hasper, D; Pschowski, R; Reinke, P; Schefold, JC; Schuett, C; Volk, HD; von Haehling, S; Zeden, JP | 1 |
| Fülöp, F; Klivényi, P; Toldi, J; Vámos, E; Vécsei, L; Zádori, D | 1 |
| Mysliwiec, M; Pawlak, D; Pawlak, K | 1 |
| Fotopoulou, C; Fusch, G; Hammoud, B; Hasper, D; Meisel, C; Pschowski, R; Reinke, P; Schefold, JC; Schütt, C; Volk, HD; Von Haehling, S; Zeden, JP | 1 |
| Chen, Y; Guillemin, GJ; Meininger, V | 1 |
| Bien, B; Gulaj, E; Pawlak, D; Pawlak, K | 1 |
| Chen, L; Gong, CY; Li, Z; Liu, J; Wang, HM; Wang, X; Yang, J; Zhang, HW | 1 |
| Honjo, H; Iwamoto, K; Uwai, Y | 1 |
| Azechi, H; Board, M; Yamamoto, T | 1 |
| Du Preez, JL; Harvey, BH; Möller, M | 1 |
| Tan, L; Yu, JT | 1 |
| Plangar, I; Szalardy, L; Vecsei, L | 1 |
| Darlington, LG; Stone, TW; Stoy, N | 1 |
| Buerger, K; Guillemin, GJ; Hampel, H; Schwarz, MJ; Teipel, SJ | 1 |
| Brundin, L; Erhardt, S; Guillemin, GJ; Janelidze, S; Lim, CK; Linderholm, KR; Lindqvist, D; Lundberg, K; Postolache, TT; Samuelsson, M; Träskman-Bendz, L | 1 |
| Fukuwatari, T; Funakoshi, H; Kadota, E; Kanai, M; Nakamura, T; Sano, M; Shibata, K; Terakata, M | 1 |
| Bucci, DJ; Iaccarino, HF; Suckow, RF; Xie, S | 1 |
| Fang, Q; Harris, TH; Horning, KJ; Hunter, CA; Notarangelo, FM; Schwarcz, R; Thomas, MA; Wilson, EH | 1 |
| Banister, SD; Guillemin, GJ; Karl, T; Kassiou, M; Lim, CK; Purves-Tyson, T; Weickert, CS; Zavitsanou, K | 1 |
| Costantino, G | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Smith, CM; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Bay-Richter, C; Brundin, L; Erhardt, S; Guillemin, GJ; Lim, CK; Linderholm, KR; Samuelsson, M; Träskman-Bendz, L | 1 |
| Adams, S; Braidy, N; Brew, BJ; Bustamante, S; Guillemin, GJ; Lim, CK; McDonald, KL; Sundaram, G; Teo, C; Zinger, A | 1 |
| Bellgowan, PS; Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 2 |
| Elizondo, G; García-Lara, L; González-Esquivel, D; Pérez-Severiano, F; Segovia, J | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; McIntosh, SA; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Ford, BN; Meier, TB; Morris, HM; Savitz, J; Teague, TK; Victor, TA; Wurfel, BE | 1 |
| de Bie, J; Grant, R; Guest, J; Guillemin, GJ | 1 |
| Gandhi, CP; Hill, MN; Vecchiarelli, HA | 1 |
| Buras, A; Szulc, A; Waszkiewicz, N | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Perugino, F; Simmaco, M | 1 |
| Bodurka, J; Dantzer, R; Drevets, WC; Savitz, J; Teague, TK; Young, KD | 1 |
| Capi, M; Curto, M; Fazio, F; Giamberardino, MA; Lionetto, L; Martelletti, P; Negro, A; Nicoletti, F; Simmaco, M | 1 |
| Beaumont, V; Bradaia, A; Deisemann, H; Dijkman, U; Dominguez, C; Ebneth, A; Freije, R; Gelman, S; Gleyzes, M; Heikkinen, T; Heins, M; Javier, RM; Khetarpal, V; Kontkanen, O; Lehtimäki, K; Mrzljak, L; Munoz-Sanjuan, I; Neagoe, I; Park, LC; Puoliväli, J; Rassoulpour, A; Steidl, E; Toledo-Sherman, L; Tombaugh, G; Winkler, D | 1 |
| Bhat, M; Choi, DS; Engberg, G; Erhardt, S; Faka, A; Goiny, M; Imbeault, S; Larsson, MK; Liu, XC; Oliveros, A; Orhan, F; Sandberg, K; Schwieler, L; Ståhl, S | 1 |
| Brundin, L; Christensen, K; Coccaro, EF; Coussons-Read, M; Erhardt, S; Fanning, JR; Fuchs, D; Goiny, M; Lee, R | 1 |
| Bhat, M; Erhardt, S; Orhan, F; Piehl, F; Sandberg, K; Schwieler, L; Ståhl, S; Svensson, C | 1 |
| Bhat, M; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, ME; Landén, M; Schuppe-Koistinen, I; Schwieler, L; Wetterberg, L | 1 |
| Gabriele, S; Gevi, F; Persico, AM; Zolla, L | 1 |
| Bengesser, SA; Birner, A; Dalkner, N; Fellendorf, FT; Fuchs, D; Hamm, C; Herzog-Eberhard, S; Kapfhammer, HP; Maget, A; Mangge, H; Moll, N; Pilz, R; Platzer, M; Queissner, R; Rauch, P; Reininghaus, B; Reininghaus, EZ; Schütze, G; Schwarz, M; Zelzer, S | 1 |
| Anderson, G; Carvalho, AF; Geffard, M; Kanchanatawan, B; Maes, M; Ruxrungtham, K; Sirivichayakul, S | 1 |
| Bliss, SA; Dantzer, R; Drevets, WC; Ford, BN; McMillin, JR; Morris, HM; Savitz, JB; Suzuki, H; Teague, TK; Wurfel, BE | 1 |
| Cho, HJ; Dantzer, R; Drevets, WC; Irwin, MR; Savitz, J; Teague, TK | 1 |
| Biasibetti-Brendler, H; Ferreira, F; Pessoa-Pureur, R; Pierozan, P; Schmitz, F; Wyse, ATS | 1 |
| Bahrami, Z; Firouzi, M; Harirchian, MH; Hashemi-Monfared, A; Zahednasab, H | 1 |
| Arnhard, K; Fuchs, D; Koal, T; Oberacher, H; Pitterl, F; Sperner-Unterweger, B | 1 |
| Bertó, CG; Biasibetti-Brendler, H; Ferreira, FS; Manfredini, V; Pierozan, P; Prezzi, CA; Schmitz, F; Wyse, ATS | 1 |
| Graff-Guerrero, A; Iwata, Y; Kubo, K; Mimura, M; Miyazaki, T; Moriguchi, S; Nakajima, S; Noda, Y; Ogyu, K; Omura, Y; Plitman, E; Tarumi, R; Tsugawa, S; Uchida, H; Wada, M | 1 |
| Bryn, V; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Shibata, K | 1 |
| Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H | 1 |
| Cline, MA; Kadomoto, Y; Khan, MSI; Makino, R; Tachibana, T | 1 |
| Allers, KA; Doolin, K; Farrell, C; Frodl, T; Harkin, A; Liesener, A; O'Hanlon, E; O'Keane, V; Pleiner, S; Roddy, D; Tozzi, L | 1 |
| Arnone, D; Dantzer, R; Salem, H; Saraykar, S; Selvaraj, S; Teixeira, AL | 1 |
| Kanchanatawan, B; Maes, M | 1 |
| Bryn, V; Halvorsen, B; Isaksen, J; Maes, M; Ormstad, H; Saugstad, OD; Skjeldal, OH; Verkerk, R | 1 |
| Badawy, AA | 1 |
| Duan, K; Quan, C; Tan, Y; Wang, S; Wen, S; Zhang, J | 1 |
| Bansal, Y; Kuhad, A; Razdan, K; Sharma, R | 1 |
| Beggiato, S; Giorgini, F; Notarangelo, FM; Sathyasaikumar, KV; Schwarcz, R | 1 |
| Chen, L; Li, H; Liu, W; Ning, Y; Wang, C; Zhan, Y; Zheng, W; Zhou, Y | 1 |
| Carrillo Mora, P; García Muñoz, I; García-Juárez, B; Gómez-Manzo, S; González-Esquivel, D; Jiménez Herrera, B; Marcial-Quino, J; Pérez de la Cruz, G; Pérez de la Cruz, V; Pineda, B; Ramírez-Ortega, D; Ramos-Chávez, LA; Ríos, C; Roldán-Roldán, G; Sánchez Chapul, L | 1 |
| Adams, S; Castellano-Gonzalez, G; Cole, NJ; Don, E; Guillemin, GJ; Jacobs, KR; Lim, CK; Lovejoy, DB | 1 |
| Baldessarini, RJ; Comparelli, A; Corigliano, V; Curto, M; Fazio, F; Ferracuti, S; Lionetto, L; Nicoletti, F; Simmaco, M | 1 |
| Abdel-Ahad, P; Blatzer, M; Callebert, J; Chrétien, F; Danckaert, A; de Maricourt, P; De Medeiros, GF; Gaillard, R; Jouvion, G; Langeron, O; Launay, JM; Maignan, A; Petit, AC; Sharshar, T; Van Steenwinckel, J; Verdonk, F; Vinckier, F | 1 |
| Bhat, M; Blennow, K; Cannon, TD; Engberg, G; Erhardt, S; Hultman, CM; Johansson, V; Kegel, M; Landén, M; Schwieler, L; Wetterberg, L; Zetterberg, H | 1 |
| Cho, JH; Eisenberger, NI; Faull, K; Hwang, L; Irwin, MR; Kruse, JL; Olmstead, R | 1 |
| Gelpi, M; Lebech, AM; Lundgren, J; Midttun, Ø; Mocroft, A; Nielsen, SD; Trøseid, M; Ueland, PM; Ullum, H | 1 |
| Allers, KA; Harkin, A; McLoughlin, DM; Ryan, KM | 1 |
| Duan, K; Hu, N; Huang, Z; Long, G; Ma, J; Quan, C; Wang, S; Yang, M; Yu, H; Zeng, G | 1 |
| Bloch, W; Hardt, L; Joisten, N; Kiesl, D; Knoop, A; Koliamitra, C; Kummerhoff, F; Metcalfe, AJ; Schenk, A; Thevis, M; Walzik, D; Zimmer, P | 1 |
| Cseh, EK; Janáky, T; Kecskeméti, G; Kormány, R; Rajda, C; Szabó, E; Szabó, Z; Tömösi, F; Vécsei, L | 1 |
| Bai, Y; Cui, Z; Li, P; Li, Y; Wang, D; Wang, Y; Zhang, J; Zheng, J | 1 |
| Coppens, V; De Picker, L; Kampen, JK; Morrens, M | 1 |
| Aydemir, Ö; Kandemir, H; Öztürk, M; Taneli, F; Yalın Sapmaz, Ş | 1 |
| Bartoli, F; Callovini, T; Carrà, G; Cavaleri, D; Cioni, RM; Crocamo, C; Misiak, B; Savitz, JB | 1 |
| Iqbal, T; Lijffijt, M; Mathew, SJ; Murphy, N; Ramakrishnan, N; Smith, MA; Swann, AC; Vo-Le, B | 1 |
| David-Bercholz, J; Harkin, A; Midttun, O; O'Farrell, K; O'Reilly, K; Rakovets, Y | 1 |
| Cao, B; Chen, Y; McIntyre, RS; Pan, Z; Ren, Z; Wang, D | 1 |
| Chiappelli, J; Cui, Y; Hong, LE; Huang, J; Kochunov, P; Tan, S; Tan, Y; Tian, B; Tian, L; Tong, J; Wang, Z; Yang, F; Zhang, P; Zhou, Y | 1 |
| Notarangelo, FM; Schwarcz, R | 1 |
| Braidy, N; Guillemin, GJ; Joisten, N; Ruas, JL; Zimmer, P | 1 |
| de Timary, P; Delzenne, NM; Leclercq, S; Schwarz, M; Stärkel, P | 1 |
| Janczarek, I; Kędzierski, W; Kowalik, S; Sadok, I; Staniszewska, M | 1 |
| Ostapiuk, A; Urbanska, EM | 1 |
| Fukushima, T; Onozato, M; Sakamoto, T; Umino, M | 1 |
| Asratian, A; Boda, S; Dantzer, R; Erhardt, S; Hamilton, JP; Heilig, M; Holm, L; Kämpe, R; Paul, ER; Samuelsson, M; Schwieler, L; Trepci, A; Yngve, A | 1 |
| Altunçekiç Yıldırım, A; Ceran Serdar, C; Cihan, M; Doğan, Ö; Kurt, C; Serdar, MA | 1 |
| Cameron-Smith, D; Chong, MFF; Chong, YS; Eriksson, JG; Fortier, MV; Gluckman, PD; Godfrey, KM; Kothandaraman, N; Lee, YS; Michael, N; Sadananthan, SA; Tan, KH; Tan, KM; Tint, MT; Velan, SS; Yap, F | 1 |
| Al-Hakeim, HK; Almulla, AF; Maes, M; Solmi, M; Tunvirachaisakul, C; Vasupanrajit, A; Verkerk, R | 1 |
| Akdoğan, N; Altıngöz, SM; Balcı, N; Günhan, M; Kurgan, Ş; Önder, C; Serdar, MA | 1 |
| Abusoglu, S; Eryavuz Onmaz, D; Kuzu, M; Sivrikaya, A; Tezcan, D; Unlu, A; Yerlikaya, FH; Yilmaz, S | 1 |
| Li, R; Long, X; Mu, L; Qiao, J; Wang, S; Zhang, C; Zhang, Y; Zhao, Y | 1 |
| Aupperle, RL; Burrows, K; Figueroa-Hall, LK; Khalsa, SS; Paulus, MP; Savitz, J; Teague, TK; Yeh, FC; Zheng, H | 1 |
| Boersma, E; Boomars, KA; Cai, Z; de Rijke, YB; Duncker, DJ; Geenen, LW; Guignabert, C; Kema, I; Klein, T; Koudstaal, T; Merkus, D; Reiss, IKM; Tian, S; Tran-Lundmark, K; Tu, L; van den Bosch, AE; van der Ley, C; Van Faassen, M | 1 |
| Arnhard, K; Fuchs, D; Geisler, S; Gleissenthall, GV; Kemmler, G; Mechtcheriakov, S; Oberacher, H; Schurr, T; Unterberger, C | 1 |
| Andrea, G; Cristina, B; Fabio, T; Luca, P; M C, BJ; Nicoletta, B; Sara, C; Silvia, A; Silvio, B; Veronica, R | 1 |
| Fujigaki, H; Fujigaki, S; Hasegawa, M; Hirakawa, M; Kubota, H; Kunisawa, K; Mori, Y; Mouri, A; Nabeshima, T; Niijima, M; Saito, K; Yamamoto, Y | 1 |
| Ad, Y; Baar, K; Pathak, SJ; Ramsey, JJ; Rutkowsky, JM; Steffen, D; Tran, T; Zhou, Z | 1 |
| Antony, J; Ardern-Holmes, S; Bandodkar, S; Dale, RC; Gill, D; Guillemin, GJ; Guller, A; Gupta, S; Han, VX; Heng, B; Innes, EA; Jones, HF; Kothur, K; Menezes, MP; Mohammad, S; Patel, S; Pires, AS; Tantsis, E; Troedson, C; Tsang, E; Webster, R; Wienholt, L; Yan, J | 1 |
| Ford, BN; Khalsa, S; Kuplicki, R; Paulus, MP; Savitz, J; Teague, TK | 1 |
| An, H; Bai, L; Fan, H; Ma, B; Ma, T; Qi, S; Wang, Z; Yang, F; Yun, Y; Zhang, Q; Zhao, W | 1 |
| Anderson, EW; Aranow, C; Arazi, A; Diamond, B; Furie, RA; Goodwin, S; Jin, Y; Mackay, M; Roeser, J; Shih, A; Volpe, B | 1 |
| Fathi, M; Hajiesmaeili, M; Jazi, K; Klegeris, A; Mafi, Z; McElhinney, A; Mohamadkhani, A; Sayehmiri, F; Tavasol, A; Vakili, K; Yaghoobpoor, S | 1 |
| Ageev, AA; Appolonova, SA; Belenkov, YN; Korobkova, EO; Kozhevnikova, MV; Krivova, AV; Moskaleva, NE; Privalova, EV; Shestakova, KM | 1 |
| Bi, Y; Chen, Y; Ju, Y; Li, L; Liao, M; Liu, B; Liu, J; Ma, M; Ou, W; Qin, Y; Zhang, Y | 1 |
| Abusoglu, S; Ekmekci, AH; Isık, SMT; Onmaz, DE; Ozturk, S; Unlu, A | 1 |
| Cetin, I; Dokuyucu, R; Simsek, S; Yildirim, V | 1 |
27 review(s) available for quinolinic acid and kynurenic acid
| Article | Year |
|---|---|
[Kynurenine and its metabolites in nervous system diseases].
Topics: Humans; Kynurenic Acid; Kynurenine; Nervous System Diseases; Quinolinic Acid; Quinolinic Acids | 1992 |
Effects of quinolinic and kynurenic acids on central neurons.
Topics: Action Potentials; Animals; Brain; Convulsants; gamma-Aminobutyric Acid; Glycine; Kynurenic Acid; Models, Neurological; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 1991 |
Quinolinic acid and kynurenic acid in the mammalian brain.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases | 1991 |
Metabolism and function of brain kynurenines.
Topics: Animals; Brain; Brain Diseases; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 1993 |
Metabolism and neuropathologic significance of quinolinic acid and kynurenic acid.
Topics: Animals; Disease Models, Animal; HIV Infections; HIV-1; Humans; Kynurenic Acid; Neuritis; Neuroimmunomodulation; Quinolinic Acid | 1993 |
Basic mechanisms of kynurenine actions in the central nervous system.
Topics: Animals; Anticonvulsants; Central Nervous System; Humans; Indoles; Kynurenic Acid; Kynurenine; Mammals; Neurons; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 1996 |
Kynurenic acid antagonists and kynurenine pathway inhibitors.
Topics: Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Parkinson Disease; Prodrugs; Quinolinic Acid; Schizophrenia | 2001 |
Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities.
Topics: Animals; Brain; Humans; Kynurenic Acid; Kynurenine; Neuroglia; Neurons; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2002 |
Basic science behind the catastrophic epilepsies.
Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Corticotropin-Releasing Hormone; Epilepsies, Myoclonic; Epilepsy; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; N-Methylaspartate; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Serotonin; Spasms, Infantile; Tryptophan | 2004 |
Integrative hypothesis for Huntington's disease: a brief review of experimental evidence.
Topics: Animals; Calcium; Cell Death; Disease Models, Animal; Energy Metabolism; Excitatory Amino Acids; Humans; Huntington Disease; Inflammation; Kynurenic Acid; Mice; Mice, Transgenic; Mutation; Neurons; Nitro Compounds; Oxidative Stress; Propionates; Quinolinic Acid; Serotonin Plasma Membrane Transport Proteins; Trinucleotide Repeats; Tryptophan | 2007 |
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.
Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenic Acid; Mitochondrial Diseases; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolinic Acid; Tryptophan | 2009 |
The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
Topics: Aging; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Enzyme Inhibitors; Humans; Huntington Disease; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Microglia; Molecular Targeted Therapy; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Quinolinic Acid; Receptors, G-Protein-Coupled; Receptors, N-Methyl-D-Aspartate; Tryptophan | 2012 |
An expanding range of targets for kynurenine metabolites of tryptophan.
Topics: Animals; Excitatory Amino Acid Antagonists; Humans; Kynurenic Acid; Kynurenine; Metabolic Networks and Pathways; Molecular Targeted Therapy; Oxidation-Reduction; Quinolinic Acid; Tryptophan | 2013 |
[Depression and inflammation in rheumatic diseases].
Topics: Cytokines; Depression; Humans; Hypothalamo-Hypophyseal System; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Kynurenine; Monoamine Oxidase; Pituitary-Adrenal System; Quinolinic Acid; Rheumatic Diseases; Serotonin | 2016 |
Kynurenine pathway in depression: A systematic review and meta-analysis.
Topics: Brain; Depression; Depressive Disorder; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2018 |
Organ Co-Relationship in Tryptophan Metabolism and Factors That Govern the Biosynthesis of Nicotinamide from Tryptophan.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Diet; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Liver; Niacinamide; Nutritional Status; Pentosyltransferases; Quinolinic Acid; Tryptophan; Vitamin B Deficiency; Xanthurenates | 2018 |
Role of Kynurenine pathway and its metabolites in mood disorders: A systematic review and meta-analysis of clinical studies.
Topics: Humans; Kynurenic Acid; Kynurenine; Mood Disorders; Quinolinic Acid; Serotonin; Signal Transduction; Tryptophan | 2018 |
Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognitive Dysfunction; Drug Development; Humans; Kynurenic Acid; Kynurenine; Neuroprotection; Neuroprotective Agents; Quinolinic Acid | 2018 |
Blood-based kynurenine pathway alterations in schizophrenia spectrum disorders: A meta-analysis.
Topics: Aged; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2020 |
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.
Topics: Adult; Bipolar Disorder; Humans; Kynurenic Acid; Kynurenine; Observational Studies as Topic; Quinolinic Acid; Tryptophan | 2021 |
Dysregulation of kynurenine pathway and potential dynamic changes of kynurenine in schizophrenia: A systematic review and meta-analysis.
Topics: Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Topics: Chronic Disease; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2021 |
Kynurenic acid in neurodegenerative disorders-unique neuroprotection or double-edged sword?
Topics: Alzheimer Disease; Animals; Brain; Excitatory Amino Acid Antagonists; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Parkinson Disease; Quinolinic Acid; Signal Transduction | 2022 |
A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids.
Topics: Chromatography, High Pressure Liquid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.
Topics: Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Quinolinic Acid; Schizophrenia; Tryptophan | 2022 |
Dynamic changes in kynurenine pathway metabolites in multiple sclerosis: A systematic review.
Topics: Humans; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2022 |
The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis.
Topics: Biomarkers; Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2023 |
6 trial(s) available for quinolinic acid and kynurenic acid
| Article | Year |
|---|---|
Treatment with granulocyte-macrophage colony-stimulating factor is associated with reduced indoleamine 2,3-dioxygenase activity and kynurenine pathway catabolites in patients with severe sepsis and septic shock.
Topics: Aged; Calcitonin; Calcitonin Gene-Related Peptide; Granulocyte-Macrophage Colony-Stimulating Factor; HLA-DR Antigens; Humans; Immunologic Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Placebos; Protein Precursors; Quinolinic Acid; Sepsis; Serotonin; Shock, Septic; Treatment Outcome; Tryptophan | 2010 |
Effect of l-tryptophan and its metabolites on food passage from the crop in chicks.
Topics: Administration, Oral; Alanine; Animals; Asparagine; Chickens; Crop, Avian; Gastrointestinal Motility; Glycine; Kynurenic Acid; Male; Quinolinic Acid; Tryptophan | 2018 |
Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study.
Topics: Adult; Affect; Cytokines; Depression; Endotoxins; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Sex Factors; Tryptophan; Tumor Necrosis Factor-alpha | 2019 |
Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training.
Topics: Adult; Cross-Over Studies; Endurance Training; Exercise; Humans; Hydrocortisone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-6; Kynurenic Acid; Kynurenine; Leukocytes, Mononuclear; Male; Quinolinic Acid; Resistance Training; Transaminases; Tryptophan | 2020 |
A randomized cross-over trial to define neurophysiological correlates of AV-101 N-methyl-D-aspartate receptor blockade in healthy veterans.
Topics: Adult; Cross-Over Studies; Female; Humans; Kynurenic Acid; Kynurenine; Neuroprotective Agents; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Veterans | 2021 |
Acute administration of ibuprofen increases serum concentration of the neuroprotective kynurenine pathway metabolite, kynurenic acid: a pilot randomized, placebo-controlled, crossover study.
Topics: Adult; Cross-Over Studies; Female; Humans; Ibuprofen; Kynurenic Acid; Kynurenine; Pilot Projects; Quinolinic Acid | 2022 |
190 other study(ies) available for quinolinic acid and kynurenic acid
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Alteration of mice L-tryptophan metabolism by the organophosphorous acid triester diazinon.
Topics: Animals; Arylformamidase; Diazinon; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Models, Biological; NAD; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 1992 |
Effect of salmon calcitonin on the lethality of quinolinic acid, an excitatory amino acid.
Topics: Amino Acids; Animals; Binding, Competitive; Calcitonin; Dose-Response Relationship, Drug; Drug Interactions; Kynurenic Acid; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Quinolinic Acid; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Salmon | 1992 |
Thiokynurenates prevent excitotoxic neuronal death in vitro and in vivo by acting as glycine antagonists and as inhibitors of lipid peroxidation.
Topics: Animals; Cell Survival; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Lipid Peroxidation; Male; Neurons; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.
Topics: Aged; Animals; Brain Diseases; Encephalitis; Female; HIV Infections; Humans; Kynurenic Acid; Kynurenine; Macaca; Male; Middle Aged; Nervous System Diseases; Neuritis; Quinolinic Acid; Simian Acquired Immunodeficiency Syndrome | 1992 |
Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse.
Topics: Animals; Antibodies, Monoclonal; Brain; Immune System; Interferon-gamma; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Models, Biological; Pokeweed Mitogens; Quinolinic Acid; Recombinant Proteins; Tryptophan | 1992 |
Action of picolinic acid and structurally related pyridine carboxylic acids on quinolinic acid-induced cortical cholinergic damage.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Male; Neurons; Neurotoxins; Picolinic Acids; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1992 |
Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid.
Topics: Animals; Atrophy; Brain; Cisterna Magna; Convulsants; Injections; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tryptophan | 1992 |
Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats.
Topics: Aminooxyacetic Acid; Animals; Brain Diseases; Dialysis; Drug Interactions; Hippocampus; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin; Veratridine | 1992 |
The regulation of brain kynurenic acid content: focus on indole-3-pyruvic acid.
Topics: Animals; Biological Clocks; Brain; Brain Chemistry; Enzyme Induction; Humans; Indoles; Interferon Inducers; Kynurenic Acid; Mice; Neurotoxins; Organ Specificity; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tryptophan; Tryptophan Oxygenase | 1991 |
Is quinolinic acid an endogenous excitotoxin in alcohol withdrawal?
Topics: Alcoholism; Animals; Brain; Humans; Kynurenic Acid; Models, Neurological; Quinolinic Acid; Quinolinic Acids; Substance Withdrawal Syndrome; Synaptic Transmission; Tryptophan | 1991 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1991 |
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates | 1991 |
Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine.
Topics: Alanine; Animals; Brain; Endotoxins; Escherichia coli; Gas Chromatography-Mass Spectrometry; Kidney; Kynurenic Acid; Lipopolysaccharides; Liver; Male; Models, Neurological; Niacin; Organ Specificity; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Indolic and kynurenine pathway metabolites of tryptophan in rat brain: effect of precursor availability on in vivo release.
Topics: Animals; Corpus Striatum; Dialysis; Extracellular Space; Indoles; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Serotonin; Tryptophan | 1991 |
Production of quinolinic acid and kynurenic acid by human glioma.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Astrocytoma; Brain Neoplasms; Dioxygenases; Humans; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neoplasm Proteins; Oxygenases; Quinolinic Acid; Quinolinic Acids | 1991 |
Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D.
Topics: Animals; Brain; Kynurenic Acid; Macaca mulatta; Quinolinic Acid; Quinolinic Acids; Reference Values; Retroviruses, Simian; Simian Acquired Immunodeficiency Syndrome; Tryptophan | 1990 |
Quinolinate neurotoxicity and glutamatergic structures.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Injections, Intraventricular; Ketamine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1990 |
Increased cerebrospinal fluid quinolinic acid, kynurenic acid, and L-kynurenine in acute septicemia.
Topics: Acute Disease; Animals; Female; Kynurenic Acid; Kynurenine; Macaca mulatta; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Sepsis | 1990 |
Neurotoxicity of tryptophan metabolites.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Kynurenic Acid; Male; NADP; Nervous System Diseases; Neurons; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1990 |
Quinolinate-induced cortical cholinergic damage: modulation by tryptophan metabolites.
Topics: 3-Hydroxyanthranilic Acid; Acetylcholine; Animals; Brain; Cerebral Cortex; In Vitro Techniques; Kynurenic Acid; Male; Neurotoxins; Parietal Lobe; Picolinic Acids; Potassium; Quinolines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1990 |
Kynurenic acid antagonizes hippocampal quinolinic acid neurotoxicity: behavioral and histological evaluation.
Topics: Animals; Exploratory Behavior; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Male; Microinjections; Nerve Degeneration; Neurons; Pyramidal Tracts; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1990 |
Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral status.
Topics: Animals; Catecholamines; Kynurenic Acid; Macaca; Macaca mulatta; Pyridines; Quinolinic Acid; Quinolinic Acids; Retroviridae Infections; Tryptophan | 1990 |
Kynurenic acid protects against the neurochemical and behavioral effects of unilateral quinolinic acid injections into the nucleus basalis of rats.
Topics: Animals; Basal Ganglia; Feeding Behavior; Kynurenic Acid; Male; Memory; Motor Activity; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1989 |
Effect of MK-801, kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Glycine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1989 |
[Effects of antagonists of exciting amino acids on the neuro-destructive effect of quinolinic acid in vitro in comparison with their anticonvulsive action in situ].
Topics: Animals; Anticonvulsants; Cells, Cultured; Dicarboxylic Acids; Hippocampus; Imidazoles; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neurons; Pyridines; Quinolinic Acid; Quinolinic Acids | 1989 |
Production of extracellular quinolinic acid in the striatum studied by microdialysis in unanesthetized rats.
Topics: 3-Hydroxyanthranilic Acid; Animals; Corpus Striatum; Extracellular Space; Ibotenic Acid; Kynurenic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptophan | 1989 |
N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100.
Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Kinetics; Kynurenic Acid; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Temperature; Tissue Distribution | 1989 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Ca2+-dependent depolarization and burst firing of rat CA1 pyramidal neurones induced by N-methyl-D-aspartic acid and quinolinic acid: antagonism by 2-amino-5-phosphonovaleric and kynurenic acids.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Aspartic Acid; Calcium; Convulsants; Electric Conductivity; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Pyramidal Tracts; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Valine | 1986 |
A quantitative pharmacological analysis of some excitatory amino acid receptors in the mouse neocortex in vitro.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cerebral Cortex; Ibotenic Acid; In Vitro Techniques; Kynurenic Acid; Male; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, Amino Acid; Receptors, Cell Surface; Valine | 1988 |
Kynurenic acid and AP5 distinguish between NMDA receptor agonists.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Ibotenic Acid; Kynurenic Acid; Mice; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine | 1988 |
Quinolinic acid neurotoxicity in the nucleus basalis antagonized by kynurenic acid.
Topics: Acetylcholinesterase; Animals; Basal Ganglia; Cerebral Cortex; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Kynurenic Acid; Male; Neural Pathways; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substantia Innominata | 1985 |
The neurotoxic actions of quinolinic acid in the central nervous system.
Topics: Animals; Biotransformation; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Humans; Kynurenic Acid; Neurons; Pentosyltransferases; Potassium; Pyridines; Quinolinic Acid; Quinolinic Acids; Tissue Distribution | 1986 |
Antagonism of seizures induced by the administration of the endogenous convulsant quinolinic acid into rat brain ventricles.
Topics: Animals; Anticonvulsants; Diazepam; gamma-Aminobutyric Acid; Glycine; Injections, Intraventricular; Kynurenic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Taurine | 1986 |
Kynurenic acid-induced protection of neurochemical and behavioural deficits produced by quinolinic acid injections into the nucleus basalis of rats.
Topics: Acetylcholinesterase; Animals; Basal Ganglia; Cerebral Cortex; Kynurenic Acid; Male; Memory; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substantia Innominata | 1986 |
Neuropharmacological actions of kynurenic and quinolinic acids on horizontal cells of the isolated fish retina.
Topics: Animals; Aspartic Acid; Cobalt; Cyprinidae; Evoked Potentials, Visual; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Photic Stimulation; Pyridines; Quinolinic Acid; Quinolinic Acids; Retina | 1986 |
Anti-excitotoxic actions of taurine in the rat hippocampus studied in vivo and in vitro.
Topics: Action Potentials; Animals; Dialysis; Hippocampus; Kynurenic Acid; Organ Culture Techniques; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Seizures; Taurine | 1986 |
Quinolinate neurotoxicity in cortical cell culture.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Kynurenic Acid; L-Lactate Dehydrogenase; Mice; Neuroglia; Pyridines; Quinolinic Acid; Quinolinic Acids | 1987 |
Actions of kynurenic acid and quinolinic acid in the rat hippocampus in vivo.
Topics: Amino Acids; Animals; Electric Stimulation; Hippocampus; Iontophoresis; Kynurenic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1985 |
Effect of tryptophan metabolites on the activities of rat liver pyridoxal kinase and pyridoxamine 5-phosphate oxidase in vitro.
Topics: Animals; Kinetics; Kynurenic Acid; Liver; Male; Oxidoreductases Acting on CH-NH Group Donors; Phosphotransferases; Picolinic Acids; Pyridoxal Kinase; Pyridoxaminephosphate Oxidase; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tryptamines; Tryptophan; Xanthurenates | 1985 |
Involvement of excitatory amino acid receptors in the mechanisms underlying excitotoxic phenomena.
Topics: Action Potentials; Amino Acids, Dicarboxylic; Animals; Cell Survival; Dendrites; Epilepsy; Kynurenic Acid; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship; Synaptic Membranes | 1986 |
An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid.
Topics: Acetylcholine; Animals; Aspartic Acid; Cerebral Cortex; Convulsants; Drug Interactions; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neuromuscular Depolarizing Agents; Niacinamide; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1982 |
Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Hippocampus; Kynurenic Acid; Male; Nerve Degeneration; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1984 |
Actions of excitatory amino acids and kynurenic acid in the primate hippocampus: a preliminary study.
Topics: Amino Acids; Animals; Aspartic Acid; Callitrichinae; Hippocampus; In Vitro Techniques; Kynurenic Acid; N-Methylaspartate; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1984 |
In vivo release of [3H]-purines by quinolinic acid and related compounds.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Cerebral Cortex; Kynurenic Acid; Male; N-Methylaspartate; Purines; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Tritium | 1983 |
Cerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: relation to clinical and biochemical variable.
Topics: Adolescent; Adult; Anorexia Nervosa; Body Weight; Brain; Bulimia; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Quinolinic Acid; Thinness; Tryptophan | 1995 |
Metabolism of L-tryptophan to kynurenate and quinolinate in the central nervous system: effects of 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Cell Line; Central Nervous System; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Lyases; Macaca mulatta; Quinolinic Acid; Transaminases; Tryptophan | 1995 |
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.
Topics: Alanine; Animals; Anticonvulsants; Behavior, Animal; Drug Interactions; Extracellular Space; Hydrolases; Hypnotics and Sedatives; Kinetics; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Quinolinic Acid; Rats; Rats, Wistar | 1995 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Pentafluorobenzylation method for quantification of acidic tryptophan metabolites using electron capture negative ion mass spectrometry.
Topics: Fluorobenzenes; Kynurenic Acid; Kynurenine; Mass Spectrometry; Molecular Structure; ortho-Aminobenzoates; Picolinic Acids; Quaternary Ammonium Compounds; Quinolinic Acid; Tryptophan; Xanthurenates | 1995 |
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.
Topics: Alanine; Animals; Anticonvulsants; Brain Chemistry; Electroshock; Excitatory Amino Acid Antagonists; Hydrolases; Hypnotics and Sedatives; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neuroglia; Niacin; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate | 1994 |
A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biopterins; Brain; Encephalitis; Fetus; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Macaca mulatta; Myelitis; Neopterin; Poliomyelitis; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase | 1993 |
Intravenous administration of L-kynurenine to rhesus monkeys: effect on quinolinate and kynurenate levels in serum and cerebrospinal fluid.
Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Female; Infusions, Intravenous; Kynurenic Acid; Kynurenine; Macaca mulatta; Quinolinic Acid; Time Factors | 1993 |
L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats.
Topics: 2-Aminoadipic Acid; Animals; Brain Diseases; Dialysis; Hippocampus; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Veratridine | 1995 |
Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N-methyl-D-aspartate and quinolinic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
The kynurenines and the seizures.
Topics: Animals; Cerebral Ventricles; Electroencephalography; Hippocampus; Kynurenic Acid; Kynurenine; Microinjections; Neurons; ortho-Aminobenzoates; Penicillin G; Quinolinic Acid; Rats; Seizures | 1996 |
Enzyme-catalyzed production of the neuroprotective NMDA receptor antagonist 7-chlorokynurenic acid in the rat brain in vivo.
Topics: Animals; Brain; Citrates; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1997 |
Protection against quinolinic acid-mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid.
Topics: Alanine; Animals; Corpus Striatum; Dopamine; Drug Combinations; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; N-Methylaspartate; Neurons; Neurotoxins; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase | 1997 |
Tryptophan and its metabolite, kynurenine, stimulate expression of nerve growth factor in cultured mouse astroglial cells.
Topics: Animals; Astrocytes; Cells, Cultured; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Quinolinic Acid; RNA, Messenger; Serotonin; Tryptophan | 1998 |
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; GABA Antagonists; Huntington Disease; Injections, Intraventricular; Kynurenic Acid; Kynurenine; Male; NADP; Neurons, Afferent; Niacin; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
The analgesic effects of tryptophan and its metabolites in the rat.
Topics: Analgesics; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hypolipidemic Agents; Iron Chelating Agents; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Pain; Picolinic Acids; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex; Tryptophan; Xanthurenates | 1998 |
Metabolic control of kynurenic acid formation in the rat brain.
Topics: Animals; Brain; Corpus Striatum; Electrophysiology; Energy Metabolism; Formazans; Kynurenic Acid; Kynurenine; Male; Potassium; Pyruvic Acid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Sodium; Substrate Specificity; Tetrazolium Salts; Veratridine | 1998 |
Quinolinic acid lesion of the nigrostriatal pathway: effect on turning behaviour and protection by elevation of endogenous kynurenic acid in Rattus norvegicus.
Topics: Alanine; Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; Hydrolases; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Motor Activity; Neurons; Neuroprotective Agents; Niacin; Parkinson Disease, Secondary; Probenecid; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation | 1999 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
Acute and chronic changes in kynurenate formation following an intrastriatal quinolinate injection in rats.
Topics: Animals; Corpus Striatum; Glutamate Decarboxylase; Injections; Isoenzymes; Kinetics; Kynurenic Acid; Lyases; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substantia Nigra; Time Factors; Transaminases | 1999 |
3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Animals; Brain; Dioxygenases; Enzyme Inhibitors; Hydroxyindoleacetic Acid; Kynurenic Acid; Male; Oxygenases; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serotonin; Tryptophan | 1999 |
Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus.
Topics: Animals; Brain Diseases; Dialysis Solutions; Hippocampus; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Microdialysis; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum.
Topics: 3-Hydroxyanthranilic Acid; Animals; Biotransformation; Corpus Striatum; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Infusions, Parenteral; Kynurenic Acid; Kynurenine; Male; Malonates; Neurons; Neuroprotective Agents; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glycine | 2000 |
Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo.
Topics: 3-Hydroxyanthranilic Acid; Animals; Blood-Brain Barrier; Butyrates; Enzyme Inhibitors; Hippocampus; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mixed Function Oxygenases; Neuroprotective Agents; Neurotoxins; Pyramidal Cells; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
Neuroprotective potency of kynurenic acid against excitotoxicity.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Kynurenic Acid; Male; Microdialysis; N-Methylaspartate; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 2000 |
Characterisation of kynurenine pathway metabolism in human astrocytes and implications in neuropathogenesis.
Topics: Astrocytes; Cells, Cultured; Fetus; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Interleukin-1; Interleukin-6; Kynurenic Acid; Kynurenine; Models, Biological; Neurotoxins; Quinolinic Acid; Tumor Necrosis Factor-alpha | 2000 |
Tryptophan and tyrosine catabolic pattern in neuropsychiatric disorders.
Topics: Adult; Biogenic Monoamines; Brain Diseases; Brain Neoplasms; Digoxin; Epilepsy, Generalized; Erythrocytes; Fatty Acids, Nonesterified; Female; Glioma; Glycine Agents; Humans; Hydroxymethylglutaryl CoA Reductases; Kynurenic Acid; Magnesium; Male; Microvascular Angina; Middle Aged; Morphine; Narcotics; Nicotine; Nicotinic Agonists; Parkinson Disease; Quinolinic Acid; Schizophrenia; Serum Albumin; Sodium-Potassium-Exchanging ATPase; Strychnine; Tryptophan; Tyrosine; Ubiquinone | 2000 |
In vivo assessment of kynurenate neuroprotective potency and quinolinate excitotoxicity.
Topics: Animals; Enzyme Inhibitors; Frontal Lobe; Kynurenic Acid; Male; Neuroprotective Agents; Quinolinic Acid; Rats; Sulfonamides; Thiazoles | 2000 |
Kynurenic acid influences the respiratory parameters of rat heart mitochondria.
Topics: Animals; Cell Respiration; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Kynurenine; Malates; Male; Mitochondria, Heart; Oxygen Consumption; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency.
Topics: Animals; Brain; Brain Chemistry; Embolism; Female; Femoral Artery; Gestational Age; Glial Fibrillary Acidic Protein; Kynurenic Acid; Microspheres; Placenta; Placental Insufficiency; Pregnancy; Quinolinic Acid; Sheep | 2001 |
Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo.
Topics: Animals; Corpus Striatum; Injections, Intraperitoneal; Kynurenic Acid; Kynurenine; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Osmolar Concentration; Prodrugs; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Changes in kynurenic, anthranilic, and quinolinic acid concentrations in rat brain tissue during development.
Topics: Aging; Animals; Animals, Newborn; Brain; Embryo, Mammalian; Female; Kynurenic Acid; Male; ortho-Aminobenzoates; Osmolar Concentration; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2001 |
Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection.
Topics: AIDS Dementia Complex; Astrocytes; Brain; Cells, Cultured; Cytokines; Enzymes; Fetus; Humans; Kynurenic Acid; Kynurenine; Models, Biological; Neurons; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction | 2001 |
Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas.
Topics: Animals; Disease Models, Animal; Embolism; Female; Fetal Blood; Fetal Diseases; Fetal Growth Retardation; Infusions, Intravenous; Kynurenic Acid; Placenta; Placental Insufficiency; Pregnancy; Pregnancy, Animal; Probability; Quinolinic Acid; Reference Values; Sensitivity and Specificity; Sheep; Tryptophan | 2001 |
Influence of adenine-induced renal failure on tryptophan-niacin metabolism in rats.
Topics: 3-Hydroxyanthranilic Acid; Adenine; Animals; Kidney; Kynurenic Acid; Liver; Male; NAD; Niacin; Quinolinic Acid; Rats; Rats, Wistar; Renal Insufficiency; Tryptophan; Xanthurenates | 2001 |
Tryptophan metabolism via the kynurenine pathway in experimental chronic renal failure.
Topics: Animals; Chromatography, High Pressure Liquid; Creatinine; Kidney; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Wistar; Time Factors; Tryptophan; Urea; Xanthurenates | 2002 |
Effect of systemic L-DOPA administration on extracellular kynurenate levels in the rat striatum.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Astrocytes; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Space; Kynurenic Acid; Levodopa; Male; Neostriatum; Neurons; Neurotoxins; Oxidopamine; Parkinson Disease; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Substantia Nigra | 2002 |
Accumulation of toxic products degradation of kynurenine in hemodialyzed patients.
Topics: Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Renal Dialysis; Tryptophan; Uremia; Xanthurenates | 2001 |
Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures.
Topics: Alanine; Animals; Brain Ischemia; Cell Death; Cell Hypoxia; Culture Media, Conditioned; Enzyme Inhibitors; Glucose; Hippocampus; In Vitro Techniques; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neurons; Neuroprotective Agents; Pyramidal Cells; Quinolinic Acid; Rats; Sulfonamides; Thiazoles | 2002 |
Neuronal A1 receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion.
Topics: Adenosine; Animals; Drug Administration Routes; Extracellular Fluid; Infusions, Parenteral; Kynurenic Acid; Male; Microdialysis; Neostriatum; Neurons; Phenethylamines; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Theophylline; Wakefulness | 2004 |
Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice.
Topics: Animals; Behavior, Animal; Blood Chemical Analysis; Brain; Brain Chemistry; Female; Humans; Kidney; Kynurenic Acid; Kynurenine; Liver; Mice; Mice, Inbred Strains; Mice, Knockout; Motor Activity; Neurons; Phenotype; Pregnancy; Quinolinic Acid; Rats; Transaminases; Tryptophan | 2004 |
Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease.
Topics: Aged; Analysis of Variance; Cerebellum; Cerebral Cortex; Frontal Lobe; Humans; Huntington Disease; Kynurenic Acid; Middle Aged; Neostriatum; Quinolinic Acid | 2004 |
Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Kynurenic Acid; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Mixed Function Oxygenases; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors | 2005 |
Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease.
Topics: Animals; Brain Chemistry; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Knockout; Microinjections; Neostriatum; Neurons; Quinolinic Acid; Transaminases | 2006 |
Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs.
Topics: Analysis of Variance; Animals; Animals, Newborn; Brain Ischemia; Cerebral Arteries; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Hypercapnia; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Swine; Time Factors; Vasodilation | 2006 |
Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro.
Topics: Animals; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Endothelial Cells; Excitatory Amino Acid Antagonists; Fibroblast Growth Factor 1; Glioblastoma; Hot Temperature; Humans; Kynurenic Acid; Mice; Neuroglia; Quinolinic Acid | 2005 |
Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice.
Topics: Age Factors; Animals; Brain Chemistry; Chromatography, Gas; Chromatography, High Pressure Liquid; Disease Models, Animal; Humans; Huntington Disease; Kynurenic Acid; Kynurenine; Mice; Mice, Transgenic; Quinolinic Acid | 2006 |
4-chloro-3-hydroxyanthranilate reduces local quinolinic acid synthesis, improves functional recovery, and preserves white matter after spinal cord injury.
Topics: 3-Hydroxyanthranilic Acid; Algorithms; Animals; Behavior, Animal; Blood-Brain Barrier; Female; Guinea Pigs; Kynurenic Acid; Myelin Sheath; Permeability; Proprioception; Quinolinic Acid; Reference Standards; Reflex, Monosynaptic; Spinal Cord Compression; Spinal Cord Injuries | 2006 |
Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications.
Topics: Animals; Animals, Newborn; Brain Chemistry; Cyclopropanes; Deoxycholic Acid; Drug Administration Schedule; Embryo, Mammalian; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Liver; Metabolic Networks and Pathways; Mice; Parturition; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2007 |
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Kynurenic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate | 2007 |
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors | 2008 |
The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression - and other conditions characterized by tryptophan depletion induced by inflammation.
Topics: Adult; Anti-Inflammatory Agents; Cytokines; Depressive Disorder; Female; Gene Expression Regulation; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Interferon-gamma; Interleukin-10; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Quinolinic Acid; Reference Values; Tryptophan; Tumor Necrosis Factor-alpha; Xanthurenates | 2007 |
Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans.
Topics: 3-Hydroxyanthranilic Acid; Adult; Chromatography, High Pressure Liquid; Feedback, Physiological; Female; Humans; Kynurenic Acid; Niacinamide; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2007 |
Effect of indoleamine dioxygenase-1 deficiency and kynurenine pathway inhibition on murine cerebral malaria.
Topics: Animals; Brain; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Malaria, Cerebral; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Picolinic Acids; Quinolinic Acid; RNA, Messenger; Sulfonamides; Thiazoles; Tryptophan Oxygenase | 2009 |
Kynurenine, quinolinic acid--the new factors linked to carotid atherosclerosis in patients with end-stage renal disease.
Topics: Adult; Age Factors; Biomarkers; C-Reactive Protein; Carotid Artery Diseases; Cross-Sectional Studies; Diabetes Complications; Disease Progression; Female; Humans; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Logistic Models; Male; Malondialdehyde; Middle Aged; Oxidative Stress; Peritoneal Dialysis, Continuous Ambulatory; Peroxides; Quinolinic Acid; Renal Dialysis; Risk Assessment; Risk Factors; Superoxide Dismutase; Ultrasonography; Uremia | 2009 |
Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum.
Topics: Adenosine; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Extracellular Fluid; Functional Laterality; Kynurenic Acid; Kynurenine; Mice; Mice, Knockout; Microdialysis; Nerve Degeneration; Norbornanes; Quinolinic Acid; Transaminases; Tritium | 2009 |
Increased indoleamine 2,3-dioxygenase (IDO) activity and elevated serum levels of tryptophan catabolites in patients with chronic kidney disease: a possible link between chronic inflammation and uraemic symptoms.
Topics: 5-Hydroxytryptophan; Adult; Aged; C-Reactive Protein; Case-Control Studies; Creatinine; Female; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Inflammation Mediators; Kidney Failure, Chronic; Kynurenic Acid; Kynurenine; Male; Middle Aged; Prognosis; Prospective Studies; Quinolinic Acid; Receptors, Tumor Necrosis Factor, Type I; Renal Dialysis; Renal Insufficiency, Chronic; Serotonin; Tryptophan; Uremia | 2009 |
Haemostatic system, biochemical profiles, kynurenines and the prevalence of cardiovascular disease in peritoneally dialyzed patients.
Topics: Adult; Antifibrinolytic Agents; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Fibrinolysin; Hemostasis; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Peptide Fragments; Peritoneal Dialysis, Continuous Ambulatory; Plasminogen Activator Inhibitor 1; Poland; Prevalence; Prothrombin; Quinolinic Acid; Receptors, Urokinase Plasminogen Activator; Thromboplastin; Tryptophan; Urokinase-Type Plasminogen Activator | 2010 |
Recent advances in the treatment of amyotrophic lateral sclerosis. Emphasis on kynurenine pathway inhibitors.
Topics: Adult; Amyotrophic Lateral Sclerosis; Animals; Brain; D-Aspartic Acid; Functional Laterality; Humans; Japan; Kynurenic Acid; Kynurenine; Motor Neurons; N-Methylaspartate; Quinolinic Acid; Riluzole; Signal Transduction; Tryptophan | 2009 |
Kynurenine and its metabolites in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2010 |
Targeting the kynurenine pathway as a potential strategy to prevent and treat Alzheimer's disease.
Topics: Alzheimer Disease; Humans; Inflammation; Kynurenic Acid; Models, Biological; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
Interaction and transport of kynurenic acid via human organic anion transporters hOAT1 and hOAT3.
Topics: Animals; Biological Transport; Estrone; Humans; Kinetics; Kynurenic Acid; Kynurenine; Oocytes; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Probenecid; Quinolinic Acid; Xenopus laevis | 2012 |
Essential role of excessive tryptophan and its neurometabolites in fatigue.
Topics: Acetylglucosaminidase; Amino Acids, Branched-Chain; Analysis of Variance; Animals; Corpus Striatum; Disease Models, Animal; Exercise Test; Exploratory Behavior; Fatigue; Female; Fluoxetine; Hydroxyindoleacetic Acid; Kynurenic Acid; Locomotion; Maze Learning; Microdialysis; Quinolinic Acid; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Stereotyped Behavior; Synaptosomes; Time Factors; Tryptophan | 2012 |
Development and validation of a single analytical method for the determination of tryptophan, and its kynurenine metabolites in rat plasma.
Topics: 3-Hydroxyanthranilic Acid; Animals; Charcoal; Chromatography, High Pressure Liquid; Depression; Kynurenic Acid; Kynurenine; Linear Models; Male; ortho-Aminobenzoates; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Schizophrenia; Social Isolation; Solid Phase Extraction; Tandem Mass Spectrometry; Tryptophan | 2012 |
Manipulation with kynurenines: a possible tool for treating neurodegenerative diseases?
Topics: Animals; Drug Design; Humans; Kynurenic Acid; Kynurenine; Neurodegenerative Diseases; Quinolinic Acid | 2012 |
Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls.
Topics: Aged; Alzheimer Disease; Biomarkers; Blood-Brain Barrier; Brain Chemistry; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Gas Chromatography-Mass Spectrometry; Humans; Kynurenic Acid; Kynurenine; Male; Neuropsychological Tests; Picolinic Acids; Quinolinic Acid; Spectrophotometry, Ultraviolet; Tryptophan | 2013 |
Connecting inflammation with glutamate agonism in suicidality.
Topics: Adult; Aged; Encephalitis; Excitatory Amino Acid Agonists; Female; Follow-Up Studies; Humans; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Mental Disorders; Middle Aged; Psychiatric Status Rating Scales; Quinolinic Acid; Retrospective Studies; Somatosensory Disorders; Spinal Puncture; Suicide; Tritium; Young Adult | 2013 |
The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
Topics: 3-Hydroxyanthranilic Acid; Animals; Body Weight; Diet; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Niacin; Niacinamide; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Xanthurenates | 2013 |
The effect of transient increases in kynurenic acid and quinolinic acid levels early in life on behavior in adulthood: Implications for schizophrenia.
Topics: Analysis of Variance; Animals; Animals, Newborn; Attention; Behavior, Animal; Brain Chemistry; Cohort Studies; Conditioning, Psychological; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fear; Female; Interpersonal Relations; Kynurenic Acid; Motor Activity; Pregnancy; Quinolinic Acid; Rats; Rats, Long-Evans | 2013 |
Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia.
Topics: Animals; Anti-Infective Agents; Brain; Disease Models, Animal; Drug Combinations; Female; Kynurenic Acid; Kynurenine; Mice; Mice, Inbred C57BL; Neuroglia; Pyrimethamine; Quinolinic Acid; RNA, Messenger; Signal Transduction; Sulfadiazine; Time Factors; Toxoplasmosis; Tryptophan | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan | 2014 |
Inhibitors of quinolinic acid synthesis: new weapons in the study of neuroinflammatory diseases.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Central Nervous System Diseases; Enzyme Inhibitors; Humans; Kynurenic Acid; Quinolinic Acid; Receptors, Nicotinic | 2014 |
Putative neuroprotective and neurotoxic kynurenine pathway metabolites are associated with hippocampal and amygdalar volumes in subjects with major depressive disorder.
Topics: Adult; Amygdala; Anhedonia; Brain-Derived Neurotrophic Factor; C-Reactive Protein; Depressive Disorder, Major; Female; Gray Matter; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Organ Size; Psychiatric Status Rating Scales; Quinolinic Acid; Receptors, Interleukin-1; Signal Transduction; Tryptophan | 2015 |
A role for inflammatory metabolites as modulators of the glutamate N-methyl-D-aspartate receptor in depression and suicidality.
Topics: Adult; Cytokines; Depressive Disorder; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Suicidal Ideation; Suicide, Attempted; Young Adult | 2015 |
Involvement of the kynurenine pathway in human glioma pathophysiology.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Astrocytes; Biosynthetic Pathways; Brain Neoplasms; Carboxy-Lyases; CD11b Antigen; Cells, Cultured; Chromatography, High Pressure Liquid; Disaccharides; Gene Expression; Glial Fibrillary Acidic Protein; Glioma; Glucuronates; Humans; Immunohistochemistry; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenic Acid; Kynurenine; Picolinic Acids; Quinolinic Acid; Reverse Transcriptase Polymerase Chain Reaction; Tryptophan; Tryptophan Oxygenase; Tumor Cells, Cultured | 2014 |
Neuroprotective kynurenine metabolite indices are abnormally reduced and positively associated with hippocampal and amygdalar volume in bipolar disorder.
Topics: Adult; Amygdala; Bipolar Disorder; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid | 2015 |
Reduction of kynurenic acid to quinolinic acid ratio in both the depressed and remitted phases of major depressive disorder.
Topics: Adolescent; Adult; Chromatography, Liquid; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Young Adult | 2015 |
Large amounts of picolinic acid are lethal but small amounts increase the conversion of tryptophan-nicotinamide in rats.
Topics: Animals; Body Weight; Carboxy-Lyases; Dose-Response Relationship, Drug; Iron Chelating Agents; Kynurenic Acid; Liver; Male; Niacinamide; ortho-Aminobenzoates; Pentosyltransferases; Picolinic Acids; Quinolinic Acid; Rats; Rats, Wistar; Tryptophan; Xanthurenates | 2014 |
Absence of aryl hydrocarbon receptors increases endogenous kynurenic acid levels and protects mouse brain against excitotoxic insult and oxidative stress.
Topics: Acetyltransferases; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain; Disease Models, Animal; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Kynurenic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neurotoxicity Syndromes; Oxidative Stress; Quinolinic Acid; Receptors, Aryl Hydrocarbon; Tryptophan | 2015 |
Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder.
Topics: Adult; Anhedonia; Biomarkers; Corpus Striatum; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Quinolinic Acid; Young Adult | 2015 |
Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder.
Topics: Adult; Brain; C-Reactive Protein; Case-Control Studies; Cerebral Cortex; Depressive Disorder, Major; Female; Gray Matter; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Neurotoxicity Syndromes; Prefrontal Cortex; Quinolinic Acid; Tryptophan | 2016 |
Central kynurenine pathway shift with age in women.
Topics: Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Middle Aged; Neopterin; Neurotoxins; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase; Young Adult | 2016 |
Acute Psychological Stress Modulates the Expression of Enzymes Involved in the Kynurenine Pathway throughout Corticolimbic Circuits in Adult Male Rats.
Topics: Animals; Brain; Corticosterone; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Limbic System; Male; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Stress, Psychological; Up-Regulation | 2016 |
Altered serum levels of kynurenine metabolites in patients affected by cluster headache.
Topics: Adult; Cluster Headache; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan; Xanthurenates | 2015 |
Kynurenine pathway metabolites are associated with hippocampal activity during autobiographical memory recall in patients with depression.
Topics: Adult; Depressive Disorder, Major; Female; Hippocampus; Humans; Kynurenic Acid; Kynurenine; Magnetic Resonance Imaging; Male; Memory, Episodic; Mental Recall; Middle Aged; Quinolinic Acid; Young Adult | 2016 |
Altered kynurenine pathway metabolites in serum of chronic migraine patients.
Topics: Adult; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; Middle Aged; Migraine Disorders; ortho-Aminobenzoates; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan; Xanthurenates | 2015 |
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiological Phenomena; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Green Fluorescent Proteins; HEK293 Cells; Hippocampus; Humans; Huntingtin Protein; Huntington Disease; In Vitro Techniques; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Transgenic; Microdialysis; Pyrimidines; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transfection; Trinucleotide Repeats | 2016 |
Repeated LPS Injection Induces Distinct Changes in the Kynurenine Pathway in Mice.
Topics: Animals; Brain; Immune System; Inflammation; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice, Inbred C57BL; Quinolinic Acid | 2016 |
Tryptophan, kynurenine, and kynurenine metabolites: Relationship to lifetime aggression and inflammatory markers in human subjects.
Topics: Adult; Aggression; Biomarkers; C-Reactive Protein; Female; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Quinolinic Acid; Tryptophan | 2016 |
Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes.
Topics: Flagellin; Gene Expression Regulation; Humans; Hydrolysis; Imidazoles; Kynurenic Acid; Kynurenine; Lipopeptides; Lipopolysaccharides; Listeria monocytogenes; Monocytes; Poly I-C; Primary Cell Culture; Protein Isoforms; Quinolinic Acid; Signal Transduction; Toll-Like Receptors; Tryptophan | 2016 |
Kynurenic acid and psychotic symptoms and personality traits in twins with psychiatric morbidity.
Topics: Bipolar Disorder; Female; Humans; Interleukin-6; Interleukin-8; Kynurenic Acid; Male; Middle Aged; Personality; Psychotic Disorders; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Tumor Necrosis Factor-alpha; Twins | 2017 |
Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism.
Topics: Autism Spectrum Disorder; Biomarkers; Case-Control Studies; Child; Child, Preschool; Chromatography, High Pressure Liquid; Coenzyme A; Dysbiosis; Female; Humans; Hydrophobic and Hydrophilic Interactions; Indoleacetic Acids; Italy; Kynurenic Acid; Male; Melatonin; Metabolomics; Pantothenic Acid; Purines; Pyrimidines; Quinolinic Acid; Riboflavin; Tryptophan; Vitamin B 6; Xanthurenates | 2016 |
Increased breakdown of kynurenine towards its neurotoxic branch in bipolar disorder.
Topics: Adult; Bipolar Disorder; Brain; Case-Control Studies; Cognition; Depression; Female; Humans; Inflammation; Kynurenic Acid; Kynurenine; Male; Middle Aged; Multivariate Analysis; ortho-Aminobenzoates; Quinolinic Acid; Tryptophan | 2017 |
Deficit Schizophrenia Is Characterized by Defects in IgM-Mediated Responses to Tryptophan Catabolites (TRYCATs): a Paradigm Shift Towards Defects in Natural Self-Regulatory Immune Responses Coupled with Mucosa-Derived TRYCAT Pathway Activation.
Topics: Adult; Biomarkers; Female; Humans; Immunity, Cellular; Immunoglobulin M; Kynurenic Acid; Male; Metabolism; Middle Aged; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Signal Transduction; Tryptophan; Xanthurenates | 2018 |
Serum kynurenic acid is reduced in affective psychosis.
Topics: Adult; Affective Disorders, Psychotic; Bipolar Disorder; Corpus Striatum; Cytokines; Depression; Depressive Disorder, Major; Female; GABAergic Neurons; Humans; Inflammation; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Psychotic Disorders; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2017 |
Sleep disturbance and kynurenine metabolism in depression.
Topics: Adult; Depression; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Sleep Wake Disorders | 2017 |
Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat Striatum.
Topics: Animals; Antioxidants; Astrocytes; Cell Communication; Cells, Cultured; Corpus Striatum; Cytoskeleton; Dizocilpine Maleate; Gap Junctions; Kynurenic Acid; Microglia; Models, Biological; N-Methylaspartate; Neurons; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
The effect of minocycline on indolamine 2, 3 dioxygenase expression and the levels of kynurenic acid and quinolinic acid in LPS-activated primary rat microglia.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenic Acid; Lipopolysaccharides; Microglia; Minocycline; Neuroglia; Quinolinic Acid; Rats; Rats, Wistar | 2018 |
A validated liquid chromatography-high resolution-tandem mass spectrometry method for the simultaneous quantitation of tryptophan, kynurenine, kynurenic acid, and quinolinic acid in human plasma.
Topics: Chromatography, High Pressure Liquid; Humans; Isotope Labeling; Kynurenic Acid; Kynurenine; Limit of Detection; Metabolome; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
Kynurenic Acid Restores Nrf2 Levels and Prevents Quinolinic Acid-Induced Toxicity in Rat Striatal Slices.
Topics: Animals; Antioxidants; Cell Nucleus; Corpus Striatum; Fluoresceins; Kynurenic Acid; Male; Mitochondria; Neuroprotective Agents; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nitrites; Oxidation-Reduction; Quinolinic Acid; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium-Potassium-Exchanging ATPase; Sulfhydryl Compounds | 2018 |
Kynurenine Pathway in Autism Spectrum Disorders in Children.
Topics: Autism Spectrum Disorder; Biomarkers; Child; Chromatography, High Pressure Liquid; Comorbidity; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2017 |
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan | 2019 |
Altered tryptophan catabolite concentrations in major depressive disorder and associated changes in hippocampal subfield volumes.
Topics: Adult; Biomarkers; C-Reactive Protein; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Chromatography, Liquid; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Female; Hippocampus; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tandem Mass Spectrometry; Tryptophan | 2018 |
The Effects of Tryptophan Catabolites on Negative Symptoms and Deficit Schizophrenia are Partly Mediated by Executive Impairments: Results of Partial Least Squares Path Modeling.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Cognition Disorders; Executive Function; Female; Humans; Immunoglobulin A; Immunoglobulin M; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Male; Middle Aged; Neuropsychological Tests; Picolinic Acids; Psychiatric Status Rating Scales; Quinolinic Acid; Schizophrenia; Schizophrenic Psychology; Tryptophan; Xanthurenates; Young Adult | 2018 |
Serum Tryptophan, Tryptophan Catabolites and Brain-derived Neurotrophic Factor in Subgroups of Youngsters with Autism Spectrum Disorders.
Topics: 5-Hydroxytryptophan; Adolescent; Analysis of Variance; Autism Spectrum Disorder; Brain-Derived Neurotrophic Factor; Child; Chromatography, High Pressure Liquid; Electroencephalography; Female; Humans; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Tryptophan | 2018 |
Hypothesis kynurenic and quinolinic acids: The main players of the kynurenine pathway and opponents in inflammatory disease.
Topics: Animals; Anti-Inflammatory Agents; Humans; Immunosuppressive Agents; Inflammation; Kynurenic Acid; Kynurenine; Male; Models, Theoretical; ortho-Aminobenzoates; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Wistar; Tryptophan | 2018 |
[Correlation between kynurenine metabolites and postpartum depression].
Topics: Biomarkers; Cesarean Section; China; Depression, Postpartum; Female; Humans; Incidence; Kynurenic Acid; Kynurenine; Pregnancy; Quinolinic Acid | 2018 |
Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia.
Topics: Animals; Brain; Cognitive Dysfunction; Female; Genotype; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Mice, Knockout; Placenta; Pregnancy; Quinolinic Acid; Schizophrenia | 2018 |
Cross-sectional relationship between kynurenine pathway metabolites and cognitive function in major depressive disorder.
Topics: Adult; Chromatography, Liquid; Cognition; Cross-Sectional Studies; Depression; Depressive Disorder, Major; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Quinolinic Acid; Tryptophan | 2019 |
Low Serum Tryptophan Levels as an Indicator of Global Cognitive Performance in Nondemented Women over 50 Years of Age.
Topics: Aged; Aged, 80 and over; Cognition; Female; Humans; Kynurenic Acid; Kynurenine; Middle Aged; Quinolinic Acid; Tryptophan | 2018 |
Kynurenine 3-Monooxygenase Activity in Human Primary Neurons and Effect on Cellular Bioenergetics Identifies New Neurotoxic Mechanisms.
Topics: Adenosine Triphosphate; Brain; Cell Survival; HEK293 Cells; Humans; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Diseases; NAD; Neurons; Oxidative Stress; Primary Cell Culture; Quinolinic Acid; Reactive Oxygen Species | 2019 |
Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Topics: Adolescent; Adult; Disease Progression; Female; Humans; Hydroxyindoleacetic Acid; Kynurenic Acid; Kynurenine; Male; ortho-Aminobenzoates; Prodromal Symptoms; Psychotic Disorders; Quinolinic Acid; Risk; Schizophrenia; Tryptophan; Xanthurenates; Young Adult | 2019 |
Microglial production of quinolinic acid as a target and a biomarker of the antidepressant effect of ketamine.
Topics: Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Biomarkers, Pharmacological; Depression; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Disease Models, Animal; Inflammation; Ketamine; Kynurenic Acid; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Quinolinic Acid | 2019 |
Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.
Topics: Adult; Aged; Bipolar Disorder; Chemokine CCL2; Cohort Studies; Female; Humans; Kynurenic Acid; Male; Middle Aged; Quinolinic Acid; Schizophrenia; Sweden; Tryptophan | 2020 |
Abdominal Adipose Tissue Is Associated With Alterations in Tryptophan-Kynurenine Metabolism and Markers of Systemic Inflammation in People With Human Immunodeficiency Virus.
Topics: Abdominal Fat; Aged; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Female; HIV; HIV Infections; Humans; Inflammation; Kynurenic Acid; Kynurenine; Longitudinal Studies; Male; Middle Aged; Neopterin; Quinolinic Acid; Tryptophan; Waist-Hip Ratio | 2020 |
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
Topics: 3-Hydroxyanthranilic Acid; Affect; Case-Control Studies; Electroconvulsive Therapy; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; ortho-Aminobenzoates; Picolinic Acids; Quinolinic Acid; Tryptophan; Xanthurenates | 2020 |
The role of kynurenine pathway and kynurenic aminotransferase alleles in postpartum depression following cesarean section in Chinese women.
Topics: Adult; Alleles; Cesarean Section; Depression, Postpartum; Female; Genotype; Humans; Kynurenic Acid; Kynurenine; Polymorphism, Single Nucleotide; Pregnancy; Quinolinic Acid; Transaminases | 2020 |
A validated UHPLC-MS method for tryptophan metabolites: Application in the diagnosis of multiple sclerosis.
Topics: Adult; Biomarkers; Calibration; Case-Control Studies; Chromatography, High Pressure Liquid; Female; Humans; Kynurenic Acid; Middle Aged; Multiple Sclerosis, Relapsing-Remitting; Picolinic Acids; Quinolinic Acid; Reference Standards; Tandem Mass Spectrometry; Tryptophan; Young Adult | 2020 |
Characterization of kynurenine pathway in patients with diarrhea-predominant irritable bowel syndrome.
Topics: Diarrhea; Female; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate | 2020 |
The role of the kynurenine pathway and quinolinic acid in adolescent major depressive disorder.
Topics: Adolescent; Cross-Sectional Studies; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2021 |
Kynurenic Acid Protects Against Reactive Glial-associated Reductions in the Complexity of Primary Cortical Neurons.
Topics: Animals; Kynurenic Acid; Kynurenine; Neuroglia; Neurons; Quinolinic Acid; Rats | 2021 |
Effects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia.
Topics: Humans; Kynurenic Acid; Kynurenine; Memory, Short-Term; Quinolinic Acid; Schizophrenia; Tryptophan | 2021 |
A single prenatal lipopolysaccharide injection has acute, but not long-lasting, effects on cerebral kynurenine pathway metabolism in mice.
Topics: Animals; Female; Kynurenic Acid; Kynurenine; Lipopolysaccharides; Male; Mice; Placenta; Pregnancy; Quinolinic Acid | 2021 |
Alterations of kynurenine pathway in alcohol use disorder and abstinence: a link with gut microbiota, peripheral inflammation and psychological symptoms.
Topics: Alcoholism; Gastrointestinal Microbiome; Humans; Inflammation; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2021 |
Does the type of exercise affect tryptophan catabolism in horses?
Topics: Animals; Chromatography, High Pressure Liquid; Horses; Kynurenic Acid; Quinolinic Acid; Tryptophan | 2021 |
Peripheral and central kynurenine pathway abnormalities in major depression.
Topics: Depression; Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2022 |
Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
Topics: Adult; Aged; COVID-19; Female; Humans; Kynurenic Acid; Kynurenine; Male; Middle Aged; Picolinic Acids; Prognosis; Quinolinic Acid; SARS-CoV-2; Tryptophan | 2022 |
The Kynurenine Pathway Metabolites in Cord Blood Positively Correlate With Early Childhood Adiposity.
Topics: Adiposity; Adult; Birth Weight; Cesarean Section; Child; Child, Preschool; Female; Fetal Blood; Humans; Infant; Infant, Newborn; Kynurenic Acid; Kynurenine; Longitudinal Studies; Pediatric Obesity; Pregnancy; Prospective Studies; Quinolinic Acid | 2022 |
Influence of periodontal inflammation on tryptophan-kynurenine metabolism: a cross-sectional study.
Topics: Cross-Sectional Studies; Humans; Inflammation; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
Topics: Behcet Syndrome; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Tryptophan | 2022 |
Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
Topics: Cross-Sectional Studies; Female; Humans; Kynurenic Acid; Kynurenine; Polycystic Ovary Syndrome; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder.
Topics: C-Reactive Protein; Depressive Disorder, Major; Diffusion Tensor Imaging; Humans; Kynurenic Acid; Kynurenine; Quinolinic Acid; Sexually Transmitted Diseases; White Matter | 2022 |
Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6Rα.
Topics: Animals; Endothelial Cells; Humans; Hypoxia; Interleukin-6; Kynurenic Acid; Kynurenine; Monocrotaline; Pulmonary Arterial Hypertension; Quinolinic Acid; Rats; Receptors, Interleukin-6 | 2022 |
Tryptophan-kynurenine metabolism during acute alcohol withdrawal in patients with alcohol use disorder: The role of immune activation.
Topics: Alcohol Drinking; Alcoholism; Biomarkers; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Kynurenic Acid; Kynurenine; Neopterin; Quinolinic Acid; Substance Withdrawal Syndrome; Tryptophan | 2022 |
Identification and characterization of the kynurenine pathway in the pond snail Lymnaea stagnalis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Lymnaea; Quinolinic Acid; Tryptophan | 2022 |
Deficiency of kynurenine 3-monooxygenase exacerbates impairment of prepulse inhibition induced by phencyclidine.
Topics: Animals; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Inbred C57BL; Phencyclidine; Prepulse Inhibition; Quinolinic Acid; RNA, Messenger | 2022 |
2-month ketogenic diet preferentially alters skeletal muscle and augments cognitive function in middle aged female mice.
Topics: Animals; Cognition; Diet, Ketogenic; Female; Kynurenic Acid; Kynurenine; Male; Mice; Muscle, Skeletal; Neurotoxins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Quinolinic Acid | 2022 |
Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids.
Topics: 3-Hydroxyanthranilic Acid; Adrenal Cortex Hormones; Animals; Biomarkers; Chromatography, Liquid; Epilepsy; Kynurenic Acid; Kynurenine; Male; Quinolinic Acid; Spasm; Tandem Mass Spectrometry; Tryptophan | 2022 |
Relationship between the tryptophan-kynurenine pathway and painful physical symptoms in patients with major depressive disorder.
Topics: Depressive Disorder, Major; Humans; Kynurenic Acid; Kynurenine; Pain; Quinolinic Acid; Serotonin; Tandem Mass Spectrometry; Tryptophan | 2022 |
Associations between circulating interferon and kynurenine/tryptophan pathway metabolites: support for a novel potential mechanism for cognitive dysfunction in SLE.
Topics: Cognitive Dysfunction; Humans; Interferons; Kynurenic Acid; Kynurenine; Lupus Erythematosus, Systemic; Quinolinic Acid; Tryptophan | 2022 |
Comparative analysis of tryptophan and downstream metabolites of the kynurenine and serotonin pathways in patients with arterial hypertension and coronary artery disease.
Topics: Atherosclerosis; Coronary Artery Disease; Humans; Hydroxyindoleacetic Acid; Hypertension; Kynurenic Acid; Kynurenine; Quinolinic Acid; Serotonin; Tryptophan | 2022 |
Relationship of tryptophan metabolites with the type and severity of multiple sclerosis.
Topics: Animals; Humans; Kynurenic Acid; Kynurenine; Mammals; Multiple Sclerosis; Quinolinic Acid; Tryptophan | 2023 |
Kynurenine, Kynurenic Acid, Quinolinic Acid and Interleukin-6 Levels in the Serum of Patients with Autism Spectrum Disorder.
Topics: Autism Spectrum Disorder; Child; Child, Preschool; Humans; Infant; Interleukin-6; Kynurenic Acid; Kynurenine; Quinolinic Acid | 2023 |