quinolinic acid has been researched along with kainic acid in 92 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (36.96) | 18.7374 |
| 1990's | 44 (47.83) | 18.2507 |
| 2000's | 12 (13.04) | 29.6817 |
| 2010's | 2 (2.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beattie, DT; Bruhn, T; Curtis, DR; Diemer, NH; Ebert, B; Ferkany, JW; Johansen, JS; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Altar, CA; Christakos, S; German, D; Iacopino, A; Sonsalla, PK | 1 |
| DiFiglia, M; Finklestein, SP; Freese, A | 1 |
| Ebstein, RP; Shoham, S; Wertman, E | 1 |
| Beninger, RJ; Boegman, RJ; Cockhill, J; Jhamandas, K | 1 |
| Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ | 1 |
| De Simoni, MG; Fodritto, F; Forloni, GL; Manfridi, A; Vezzani, A | 1 |
| Clark, AJ; Hastings, MH; Latimer, M; Stone, TW; Winn, P | 1 |
| Rios, C; Santamaria, A | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Swartz, KJ | 1 |
| Beal, MF; Vécsei, L | 1 |
| Dragunow, M; Faull, RL; Waldvogel, HJ; Williams, MN | 1 |
| Rizzi, M; Samanin, R; Serafini, R; Stasi, MA; Vezzani, A; Viganò, G | 1 |
| Kaplan, SM; Nash, DR; Norman, AB; Sanberg, PR | 1 |
| Abicht, K; Fischer, S; Hass, P; Keilhoff, G; Wolf, G | 1 |
| D'Incalci, M; Ignatowicz, E; Rizzi, M; Vezzani, AM | 1 |
| Ford, LM; Giordano, M; Sanberg, PR; Shipley, MT | 1 |
| Galarraga, E; Kitai, ST; Surmeier, DJ | 1 |
| Khaspekov, LG; Lisý, V; Stastný, F; Viktorov, IV | 1 |
| Coyle, JT; Miyamoto, M | 1 |
| McGeer, EG; Zhu, SG | 1 |
| Sagar, SM | 1 |
| Jhamandas, K; Ruzicka, BB | 1 |
| Choi, DW; Hartley, DM; Koh, J; Weiss, JH | 1 |
| Mizuno, N; Sugimoto, T | 1 |
| Allen, GS; Tulipan, NB; Whetsell, WO | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ | 1 |
| Collins, JF; Meldrum, BS; Turski, L | 1 |
| Cotman, CW; Ganong, AH | 1 |
| Addae, JI; Stone, TW | 1 |
| Choi, DW; Koh, JY; Peters, S | 1 |
| Connick, JH; Stone, TW | 2 |
| Fonnum, F; Fosse, VM | 1 |
| Lodge, D; Martin, D | 1 |
| Choi, DW; Koh, J; Peters, S | 1 |
| Samanin, R; Vezzani, A; Wu, HQ | 1 |
| Burton, NR; Smith, DA; Stone, TW | 1 |
| Boegman, RJ; Parent, A | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Beninger, RJ; Boegman, RJ; Coloma, F; el-Defrawy, SR; Jhamandas, K; Wirsching, BA | 1 |
| Beninger, RJ; Boegman, RJ; el-Defrawy, SR; Jhamandas, K; Wirsching, BA | 1 |
| Farley, JM; Huang, HM; Jin, C; Rockhold, RW | 1 |
| Boegman, RJ; Ludwin, SK; Metcalf, R; Riopelle, RJ | 1 |
| Sangalli, L; Schwarcz, R; Vezzani, A; Wu, HQ | 1 |
| Schwarcz, R; Speciale, C | 1 |
| Curry, K; Magnuson, DS; McLennan, H; Peet, MJ | 1 |
| Cohen, MR; Gutman, R; McElveen, TS; Sridhara, N | 1 |
| Davies, SW; Roberts, PJ | 1 |
| Allen, GS; Luo, SQ; Tulipan, N; Whetsell, WO | 1 |
| Baraban, JM; De Souza, EB; Snyder, SH; Worley, PF | 1 |
| French, ED; Köhler, C; Okuno, E; Schwarcz, R; Speciale, C | 1 |
| Herrling, PL; Klockgether, T; Sontag, KH; Turski, L; Watkins, JC | 1 |
| Choi, DW; Peters, S; Viseskul, V | 1 |
| Contestabile, A; Migani, P; Poli, A; Villani, L | 1 |
| Köhler, C; Schwarcz, R | 1 |
| Foster, AC; French, ED; Köhler, C; Schwarcz, R; Whetsell, WO | 1 |
| Schwarcz, R; Whetsell, WO | 1 |
| Brown, CS; Chen, Q; Harris, C; Howe, A; Reiner, A; Surmeier, DJ | 1 |
| Alberch, J; Pérez-Navarro, E | 1 |
| Fagg, GE; Massieu, L; McVey, M; Thedinga, KH | 1 |
| Greber, S; Gruber, B; Rupp, E; Sperk, G | 1 |
| Keilhoff, G; Wolf, G | 1 |
| Kaneda, H; Maeda, K | 1 |
| Ahn, A; Beal, MF; DiFiglia, M; Roberts, RC; Swartz, KJ | 1 |
| Abicht, K; Fischer, S; Hass, P; Keilhoff, G; Rothe, F; Wolf, G | 1 |
| Alberch, J; Ferrer, I; Macaya, A; Martin, F; Pérez-Navarro, E; Planas, AM; Reiriz, J; Serrano, T | 1 |
| Altemus, KL; Cepeda, C; Colwell, CS; Levine, MS | 1 |
| Friedemann, MN; Gerhardt, GA | 1 |
| Matyja, E; Renkawek, K | 1 |
| Bochet, P; de Carvalho, LP; Rossier, J | 1 |
| Altemus, KL; Colwell, CS; Levine, MS | 1 |
| Martin, LJ; Portera-Cailliau, C; Price, DL | 1 |
| Ordaz-Moreno, J; Ríos, C; Rubio-Osornio, M; Santamaría, A; Solís-Hernández, F | 1 |
| Lapin, IP; Mirzaev, SM; Oxenkrug, GF; Ryzov, IV | 1 |
| Alberch, J; Arenas, E; Canals, JM; Checa, N; Marco, S; Michels, A; Pérez-Navarro, E | 1 |
| Ginsberg, SD; Martin, LJ; Portera-Cailliau, C | 1 |
| Chen, Q; Reiner, A; Surmeier, DJ | 1 |
| Chase, TN; Nakai, M; Qin, Z; Wang, Y | 1 |
| Behan, WM; Stone, TW | 1 |
| Akerud, P; Alberch, J; Arenas, E; Canals, JM; Checa, N; Marco, S; Michels, A; Pérez-Navarro, E; Tolosa, E | 1 |
| Burgos, JS; Frizzo, ME; Lara, DR; Ramírez, G; Schmidt, AP; Souza, DO | 1 |
| Alberch, J; Canals, JM; Canudas, AM; Gavaldà, N; Marco, S; Pérez-Navarro, E | 1 |
| Lisý, V; Stastný, F | 1 |
| Cano, J; Machado, A; Rite, I; Tomás-Camardiel, M; Venero, JL | 1 |
| Alberch, J; Gavaldà, N; Gratacòs, E; Pérez-Navarro, E | 1 |
| Guidetti, P; Pellicciari, R; Sapko, MT; Schwarcz, R; Tagle, DA; Yu, P | 1 |
| McLin, JP; Steward, O | 1 |
| McLin, JP; Steward, O; Thompson, LM | 1 |
| Martin, LJ | 1 |
| Cynader, M; Fernando, S; Leavitt, BR; Lu, G; Petkau, TL; Zhu, S | 1 |
1 review(s) available for quinolinic acid and kainic acid
| Article | Year |
|---|---|
Recent advances in the use of selective neuron-destroying agents for neurobiological research.
Topics: Animals; Aziridines; Choline; Colchicine; Folic Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Lectins; Mitogens; Mustard Compounds; Nerve Degeneration; Nervous System; Neurons; Piperidines; Pyrrolidonecarboxylic Acid; Quinolinic Acid; Quinolinic Acids | 1984 |
91 other study(ies) available for quinolinic acid and kainic acid
| Article | Year |
|---|---|
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain; Cerebral Cortex; Dizocilpine Maleate; Glycine; Ibotenic Acid; In Vitro Techniques; Indicators and Reagents; Isoxazoles; Male; Molecular Structure; Neurons; Propionates; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium | 1991 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity.
Topics: Animals; Basal Ganglia Diseases; Biogenic Amines; Calbindin 1; Calbindins; Calcium; Cell Survival; Disease Models, Animal; Kainic Acid; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; RNA, Messenger; S100 Calcium Binding Protein G | 1992 |
Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity.
Topics: Animals; Cell Death; Corpus Striatum; Fibroblast Growth Factor 2; Glutamates; Glutamic Acid; Kainic Acid; Nervous System Diseases; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Iron accumulation in the rat basal ganglia after excitatory amino acid injections--dissociation from neuronal loss.
Topics: Animals; Basal Ganglia; Cell Survival; Histocytochemistry; Injections; Iron; Kainic Acid; Male; Neurons; Perfusion; Quinolinic Acid; Rats; Tissue Distribution | 1992 |
Action of picolinic acid and structurally related pyridine carboxylic acids on quinolinic acid-induced cortical cholinergic damage.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Male; Neurons; Neurotoxins; Picolinic Acids; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 1992 |
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Functional and histological consequences of quinolinic and kainic acid-induced seizures on hippocampal somatostatin neurons.
Topics: Animals; Cell Survival; Cysteamine; Electroencephalography; Epilepsy; Hippocampus; Kainic Acid; Male; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Somatostatin | 1991 |
A comparison of excitotoxic lesions of the basal forebrain by kainate, quinolinate, ibotenate, N-methyl-D-aspartate or quisqualate, and the effects on toxicity of 2-amino-5-phosphonovaleric acid and kynurenic acid in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Diseases; Ibotenic Acid; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats | 1991 |
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates | 1991 |
Chronic quinolinic acid lesions in rats closely resemble Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Atrophy; Biogenic Amines; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamates; Huntington Disease; Ibotenic Acid; Kainic Acid; Male; Mesencephalon; NADPH Dehydrogenase; Neurons; Neuropeptide Y; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Values; Somatostatin; Substance P | 1991 |
Comparative behavioral and neurochemical studies with striatal kainic acid- or quinolinic acid-lesioned rats.
Topics: Animals; Anxiety; Avoidance Learning; Behavior, Animal; Body Weight; Brain Chemistry; Corpus Striatum; Exploratory Behavior; gamma-Aminobutyric Acid; Kainic Acid; Male; Motor Activity; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Rotation; Substance P | 1991 |
Differential sensitivity of calbindin and parvalbumin immunoreactive cells in the striatum to excitotoxins.
Topics: Animals; Calbindins; Corpus Striatum; Ibotenic Acid; Immunohistochemistry; Injections; Kainic Acid; Parvalbumins; Quinolinic Acid; Quinolinic Acids; Rats; S100 Calcium Binding Protein G | 1991 |
A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus.
Topics: Animals; Atropine; Convulsants; Electroencephalography; Hippocampus; Kainic Acid; Male; Octreotide; Picrotoxin; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1991 |
An evaluation of the possible protective effects of neonatal striatal transplants against kainic acid-induced lesions.
Topics: Animals; Animals, Newborn; Body Weight; Brain Diseases; Brain Tissue Transplantation; Corpus Striatum; Kainic Acid; Male; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures; Transplantation, Homologous | 1991 |
Magnesium sulphate subcutaneously injected protects against kainate-induced convulsions and neurodegeneration: in vivo study on the rat hippocampus.
Topics: Animals; Convulsants; Hippocampus; In Vitro Techniques; Injections, Subcutaneous; Kainic Acid; Magnesium Sulfate; Male; Nerve Degeneration; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Seizures | 1991 |
Nerve cell death induced in vivo by kainic acid and quinolinic acid does not involve apoptosis.
Topics: Animals; Calcium; Cell Death; DNA; Electrophoresis, Agar Gel; Gene Expression Regulation; Hippocampus; Kainic Acid; Male; Methylprednisolone; Nerve Degeneration; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Neural grafts and pharmacological intervention in a model of Huntington's disease.
Topics: Acetylcholinesterase; Amphetamine; Animals; Brain Tissue Transplantation; Catalepsy; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Electron Transport Complex IV; Female; Fetal Tissue Transplantation; Huntington Disease; Immunohistochemistry; Kainic Acid; Motor Activity; Nerve Degeneration; Pregnancy; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1990 |
Quinolinate and kainate neurotoxicity in neostriatal cultures is potentiated by co-culturing with neocortical neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Kainic Acid; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Cytotoxic effect of glutamate and its agonists on mouse hippocampal neurons.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Pregnancy; Quinolinic Acid; Quinolinic Acids | 1990 |
Idebenone attenuates neuronal degeneration induced by intrastriatal injection of excitotoxins.
Topics: Animals; Apomorphine; Benzoquinones; Choline O-Acetyltransferase; Corpus Striatum; Glutamate Decarboxylase; Histocytochemistry; Kainic Acid; Kinetics; Male; Motor Activity; NADPH Dehydrogenase; Nerve Degeneration; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quinones; Quisqualic Acid; Rats; Rats, Inbred Strains; Ubiquinone | 1990 |
Lamotrigine protects against kainate but not ibotenate lesions in rat striatum.
Topics: Animals; Anticonvulsants; Choline O-Acetyltransferase; Corpus Striatum; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Ibotenic Acid; Kainic Acid; Lamotrigine; Male; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Triazines | 1990 |
NADPH-diaphorase reactive neurons of the rabbit retina: differential sensitivity to excitotoxins and unusual morphologic features.
Topics: Animals; Eye Proteins; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rabbits; Retina; Vitreous Body | 1990 |
Elevation of Met-enkephalin-like immunoreactivity in the rat striatum and globus pallidus following the focal injection of excitotoxins.
Topics: Animals; Corpus Striatum; Enkephalin, Methionine; Globus Pallidus; Huntington Disease; Injections; Kainic Acid; Male; N-Methylaspartate; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Radioimmunoassay; Rats; Rats, Inbred Strains | 1990 |
The calcium channel blocker nifedipine attenuates slow excitatory amino acid neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Calcium Channels; Drug Antagonism; Ibotenic Acid; In Vitro Techniques; Ion Channel Gating; Kainic Acid; Mice; N-Methylaspartate; Neurons; Nifedipine; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1990 |
Quinolinic and kainic acids can enhance calcitonin gene-related peptide-like immunoreactivity in striatal neurons with substance P-like immunoreactivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Cats; Caudate Nucleus; Corpus Striatum; Female; Kainic Acid; Male; Nerve Degeneration; Neuropeptides; Puromycin; Pyridines; Quinolinic Acid; Quinolinic Acids; Substance P | 1987 |
Alteration of kainic acid and quinolinic acid toxicity by neostriatal transplants in vitro.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Corpus Striatum; Kainic Acid; Microscopy, Electron; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Synapses | 1989 |
Differential sparing of somatostatin-neuropeptide Y and cholinergic neurons following striatal excitotoxin lesions.
Topics: Animals; Aspartic Acid; Cholinergic Fibers; Corpus Striatum; Dose-Response Relationship, Drug; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptide Y; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Somatostatin | 1989 |
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism | 1985 |
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin | 1986 |
Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex.
Topics: Administration, Topical; Amino Acids; Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin | 1986 |
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid | 1986 |
The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.
Topics: Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1986 |
Effects of kainic acid and other excitotoxins in the rat superior colliculus: relations to glutamatergic afferents.
Topics: Animals; Cholinergic Fibers; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; Neural Pathways; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Superior Colliculi; Synaptic Transmission; Tetrahydrofolates | 1986 |
Biphasic effect of quinolinate on frog spinal, but not rat cortical, neurones: N-methyl-D-aspartate-like depolarisation and a novel type of hyperpolarisation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anterior Horn Cells; Anura; Aspartic Acid; Drug Interactions; Gyrus Cinguli; Kainic Acid; Ketamine; Magnesium; Membrane Potentials; Motor Neurons; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Valine | 1987 |
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cell Membrane; Cerebral Cortex; Drug Interactions; Electrophysiology; Homocysteine; Ibotenic Acid; Kainic Acid; Magnesium; Membrane Potentials; Mice; N-Methylaspartate; Neurons; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Zinc | 1987 |
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin | 1987 |
The mouse neocortical slice: preparation and responses to excitatory amino acids.
Topics: Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bicuculline; Cerebral Cortex; Corpus Callosum; In Vitro Techniques; Kainic Acid; Male; Membrane Potentials; Mice; Mice, Inbred Strains; N-Methylaspartate; Ouabain; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Tetrodotoxin | 1987 |
Quinolinic acid effects on amino acid release from the rat cerebral cortex in vitro and in vivo.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Cerebral Cortex; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Valine | 1988 |
The response of striatal neuropeptide Y and cholinergic neurons to excitatory amino acid agonists.
Topics: Acetylcholinesterase; Animals; Cerebral Decortication; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Glutamates; Glutamic Acid; Kainic Acid; Male; Neuropeptide Y; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1988 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Functional and neurochemical cortical cholinergic impairment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Animals; Basal Ganglia; Cerebral Cortex; Choline; Cholinergic Fibers; In Vitro Techniques; Kainic Acid; Male; Neural Pathways; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substantia Innominata | 1985 |
Effects of altered cholinergic function on working and reference memory in the rat.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Hippocampus; Kainic Acid; Learning; Male; Memory; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Scopolamine; Time Factors | 1986 |
Acute tachycardia and pressor effects following injections of kainic acid into the antero-dorsal medial hypothalamus.
Topics: Animals; Aspartic Acid; Blood Pressure; Heart Rate; Hypothalamus; Injections; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains | 1987 |
Neurotoxicity of quinolinate in the rat nucleus basalis magnocellularis.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Basal Ganglia; Cerebral Cortex; Choline O-Acetyltransferase; Cholinergic Fibers; Kainic Acid; Magnesium; Male; Microinjections; Neural Pathways; Picolinic Acids; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats | 1987 |
ATP as a marker of excitotoxin-induced nerve cell death in vivo.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1987 |
Effect of systemic kainate administration on cerebral quinolinic acid metabolism in the rat.
Topics: Animals; Brain; Glutamate Decarboxylase; Kainic Acid; Male; Oxidoreductases; Pentosyltransferases; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Status Epilepticus | 1988 |
The action of quinolinate in the rat spinal cord in vitro.
Topics: Animals; Anticonvulsants; Aspartic Acid; Convulsants; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Rats, Inbred Strains; Spinal Cord | 1987 |
Neuronal damage in the albino rat: excitotoxin, microtubule inhibitor synergism.
Topics: Acetylcholinesterase; Animals; Caudate Nucleus; Colchicine; Drug Interactions; Kainic Acid; Male; Microtubules; Neurons; Putamen; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Sparing of cholinergic neurons following quinolinic acid lesions of the rat striatum.
Topics: Acetylcholinesterase; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Ibotenic Acid; Immunohistochemistry; Kainic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1988 |
Striatal grafts provide sustained protection from kainic and quinolinic acid-induced damage.
Topics: Animals; Animals, Newborn; Brain Diseases; Cell Count; Corpus Striatum; Kainic Acid; Neurons; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Lew; Time Factors | 1988 |
Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C.
Topics: Adenylyl Cyclases; Animals; Autoradiography; Binding Sites; Brain; Brain Mapping; Cerebellum; Colforsin; Hippocampus; Kainic Acid; Phorbol Esters; Protein Kinase C; Quinolinic Acid; Quinolinic Acids; Rats; Synaptic Transmission | 1986 |
Quinolinic acid: a pathogen in seizure disorders?
Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Cholinergic Fibers; Convulsants; Epilepsy; Kainic Acid; Ligands; Oxidoreductases; Pentosyltransferases; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1986 |
Muscle relaxant and anticonvulsant activity of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid, a novel N-methyl-D-aspartate antagonist, in rodents.
Topics: Animals; Anticonvulsants; Aspartic Acid; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Kainic Acid; Mice; Muscle Relaxants, Central; N-Methylaspartate; Oxadiazoles; Piperazines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reflex; Time Factors | 1987 |
Dextrorphan and levorphanol selectively block N-methyl-D-aspartate receptor-mediated neurotoxicity on cortical neurons.
Topics: Animals; Aspartic Acid; Cell Survival; Cells, Cultured; Cerebral Cortex; Dextrorphan; Kainic Acid; Levorphanol; Mice; Morphinans; N-Methylaspartate; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1987 |
Differential vulnerability of central neurons of the rat to quinolinic acid.
Topics: Animals; Brain; Corpus Striatum; Diencephalon; Epilepsy, Temporal Lobe; Hippocampus; Huntington Disease; Ibotenic Acid; Kainic Acid; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Telencephalon | 1983 |
Excitotoxic models for neurodegenerative disorders.
Topics: Amino Acids; Animals; Axons; Dendrites; Epilepsy, Temporal Lobe; Hippocampus; Humans; Ibotenic Acid; Kainic Acid; Models, Neurological; Nervous System Diseases; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats | 1984 |
The organotypic tissue culture model of corticostriatal system used for examining amino acid neurotoxicity and its antagonism: studies on kainic acid, quinolinic acid and (-) 2-amino-7-phosphonoheptanoic acid.
Topics: 2-Amino-5-phosphonovalerate; Afferent Pathways; Amino Acids; Animals; Caudate Nucleus; Corpus Striatum; Culture Techniques; Dose-Response Relationship, Drug; Frontal Lobe; Kainic Acid; Microscopy, Electron; Models, Neurological; Nerve Degeneration; Pyridines; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission | 1983 |
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Kainic Acid; Nerve Degeneration; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Protective role of nerve growth factor against excitatory amino acid injury during neostriatal cholinergic neurons postnatal development.
Topics: Animals; Animals, Newborn; Cholinergic Fibers; Excitatory Amino Acids; Kainic Acid; Male; Neostriatum; Nerve Growth Factors; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biomarkers; Cell Death; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Pipecolic Acids; Piperazines; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Differential NPY mRNA expression in granule cells and interneurons of the rat dentate gyrus after kainic acid injection.
Topics: Animals; Gene Expression; Hippocampus; In Situ Hybridization; Interneurons; Kainic Acid; Kinetics; Male; Neuropeptide Y; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Seizures | 1994 |
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cytological Techniques; Fluoresceins; Fluorescent Dyes; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; L-Lactate Dehydrogenase; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotoxins; Propidium; Quinolinic Acid; Rats; Rats, Wistar | 1993 |
Alteration in regional brain neuropeptides following intracerebroventricular infusion of excitotoxins in rats.
Topics: Age Factors; Animals; Brain; Brain Mapping; Excitatory Amino Acids; Ibotenic Acid; Injections, Intraventricular; Kainic Acid; Male; Neuropeptide Y; Neuropeptides; Quinolinic Acid; Rats; Rats, Wistar; Somatostatin | 1994 |
Intrastriatal injections of quinolinic acid or kainic acid: differential patterns of cell survival and the effects of data analysis on outcome.
Topics: Analysis of Variance; Animals; Biomarkers; Cell Survival; Corpus Striatum; Enkephalins; Functional Laterality; Kainic Acid; Male; Microinjections; NADPH Dehydrogenase; Neurons; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 1993 |
Quinolinate and kainate facilitate magnesium penetration into brain tissue.
Topics: Animals; Blood-Brain Barrier; Cerebral Ventricles; Functional Laterality; Hippocampus; Injections, Intraventricular; Kainic Acid; Kinetics; Magnesium; Male; Perfusion; Quinolinic Acid; Rats; Rats, Wistar; Time Factors | 1993 |
Both apoptosis and necrosis occur following intrastriatal administration of excitotoxins.
Topics: Animals; Apoptosis; Cell Death; Corpus Striatum; Immunohistochemistry; Kainic Acid; Male; Necrosis; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 1995 |
Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors?
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apomorphine; Cyclopentanes; GABA Agonists; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microscopy, Video; Motor Activity; N-Methylaspartate; Neostriatum; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reference Values | 1996 |
In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat.
Topics: Adolescent; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Cricetinae; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Humans; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Potassium; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1996 |
Occurrence of lamellar bodies in the rat brain organotypic cultures in normal and pathological conditions.
Topics: Animals; Astrocytes; Brain; Hypoxia; In Vitro Techniques; Kainic Acid; Nerve Degeneration; Organelles; Quinolinic Acid; Rats; Rats, Wistar | 1995 |
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.
Topics: Animals; Cerebral Cortex; Female; Glutamic Acid; Glycine; Kainic Acid; Macromolecular Substances; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Polymerase Chain Reaction; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis | 1996 |
Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum.
Topics: Analysis of Variance; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neostriatum; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1996 |
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum.
Topics: Animals; Apoptosis; Brain; Cell Death; Dizocilpine Maleate; Kainic Acid; Male; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1997 |
Neuroprotective effect of dapsone against quinolinate- and kainate-induced striatal neurotoxicities in rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Corpus Striatum; Dapsone; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Kainic Acid; Male; N-Methylaspartate; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Wistar | 1997 |
Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice.
Topics: Animals; Anticonvulsants; Brain; Convulsants; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamates; Injections, Intraperitoneal; Injections, Intraventricular; Kainic Acid; Male; Melatonin; Mice; Mice, Inbred C57BL; Motor Activity; N-Methylaspartate; Pentylenetetrazole; Quinolinic Acid; Seizures | 1998 |
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's disease.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain-Derived Neurotrophic Factor; Cycloleucine; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Male; Neostriatum; Nerve Growth Factors; Neuroprotective Agents; Neurotrophin 3; Quinolinic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum.
Topics: Animals; Denervation; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Septum Pellucidum | 1999 |
NMDA and non-NMDA receptor-mediated excitotoxicity are potentiated in cultured striatal neurons by prior chronic depolarization.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Corpus Striatum; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetus; GluK2 Kainate Receptor; GluK3 Kainate Receptor; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Potassium Chloride; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
NMDA and non-NMDA receptor-stimulated IkappaB-alpha degradation: differential effects of the caspase-3 inhibitor DEVD.CHO, ethanol and free radical scavenger OPC-14117.
Topics: Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Central Nervous System Depressants; Corpus Striatum; Cysteine Proteinase Inhibitors; DNA Fragmentation; Ethanol; Excitatory Amino Acid Antagonists; Free Radical Scavengers; Indans; Kainic Acid; Male; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; NF-kappa B; Oligopeptides; Piperazines; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Transcription Factor AP-1 | 2000 |
Role of kynurenines in the neurotoxic actions of kainic acid.
Topics: Alanine; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.
Topics: 3T3 Cells; Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Colchicine; Corpus Striatum; Disease Models, Animal; Fibroblasts; Fluorescent Dyes; Hippocampus; Huntington Disease; In Situ Hybridization; Kainic Acid; Male; Mice; Microinjections; Neural Pathways; Neurons; Nitro Compounds; Propionates; Quinolinic Acid; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; RNA, Messenger; Stilbamidines; Up-Regulation | 2001 |
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venoms; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine; Kainic Acid; Male; Mice; Neuroprotective Agents; Phenobarbital; Phosphodiesterase Inhibitors; Quinolinic Acid; Receptors, Purinergic P1 | 2001 |
Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum.
Topics: Animals; Corpus Striatum; Drosophila Proteins; Excitatory Amino Acids; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Immunohistochemistry; Kainic Acid; Ligands; Male; Nerve Growth Factors; Nerve Tissue Proteins; Neurturin; Nuclease Protection Assays; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ret; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; RNA, Messenger; Up-Regulation | 2002 |
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium | 2002 |
Expression of BDNF mRNA in substantia nigra is dependent on target integrity and independent of neuronal activation.
Topics: Animals; Axonal Transport; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Colchicine; Female; Kainic Acid; Medial Forebrain Bundle; Neurodegenerative Diseases; Neurons; Neurotoxins; Quinolinic Acid; Rats; Rats, Wistar; Receptor, trkB; RNA, Messenger; Substantia Nigra; Subthalamic Nucleus; Up-Regulation | 2003 |
Brain-derived neurotrophic factor prevents changes in Bcl-2 family members and caspase-3 activation induced by excitotoxicity in the striatum.
Topics: Animals; bcl-2-Associated X Protein; bcl-X Protein; Brain-Derived Neurotrophic Factor; Caspase 3; Caspases; Cell Death; Corpus Striatum; Dimerization; Enzyme Activation; Excitatory Amino Acid Agonists; Kainic Acid; Male; Mice; Mice, Knockout; Microinjections; Neurotoxins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinolinic Acid; Rats; Rats, Inbred F344 | 2005 |
Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease.
Topics: Animals; Brain Chemistry; Excitatory Amino Acid Agonists; Huntington Disease; Kainic Acid; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mice; Mice, Knockout; Microinjections; Neostriatum; Neurons; Quinolinic Acid; Transaminases | 2006 |
Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains.
Topics: Animals; Cell Count; Dentate Gyrus; Drug Resistance; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Hybridization, Genetic; Kainic Acid; Male; Mice; Mice, Inbred Strains; Mossy Fibers, Hippocampal; Nerve Degeneration; Organic Chemicals; Phenotype; Quinolinic Acid; Seizures; Species Specificity | 2006 |
Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains.
Topics: Animals; Chimera; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance; Genetic Predisposition to Disease; Huntington Disease; Kainic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Inbred DBA; Mice, Inbred ICR; Nerve Degeneration; Neurons; Neurotoxins; Phenotype; Quinolinic Acid; Species Specificity | 2006 |
An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneurons.
Topics: Animals; Apoptosis; Cyclophilins; Female; Green Fluorescent Proteins; Interneurons; Kainic Acid; Male; Mice; Mice, Knockout; Mice, Transgenic; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Models, Animal; Motor Neurons; Nerve Degeneration; Neurotoxins; Peptidyl-Prolyl Isomerase F; Quinolinic Acid; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sex Factors; Spinal Cord | 2011 |
Sensitivity to neurotoxic stress is not increased in progranulin-deficient mice.
Topics: Animals; Fluoresceins; Granulins; Intercellular Signaling Peptides and Proteins; Kainic Acid; Mice; Mice, Knockout; Neurotoxicity Syndromes; Neurotoxins; Nitro Compounds; Progranulins; Propionates; Quinolinic Acid; Seizures | 2013 |