quinolinic acid has been researched along with dizocilpine maleate in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (8.70) | 18.7374 |
| 1990's | 35 (50.72) | 18.2507 |
| 2000's | 17 (24.64) | 29.6817 |
| 2010's | 11 (15.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Boddeke, HW; Massieu, L; Mengod, G; Palacios, JM; Rocamora, N | 2 |
| Allegrini, PR; Sauer, D | 1 |
| Parks, TN; Zhou, N | 1 |
| Bakker, MH; Foster, AC | 1 |
| Ford, LM; Norman, AB; Sanberg, PR | 1 |
| Taylor, R | 1 |
| Brazell, C; Foster, AC; Willis, CL | 1 |
| Keilhoff, G; Stastný, F; Wolf, G | 1 |
| Ford, LM; Giordano, M; Sanberg, PR; Shipley, MT | 1 |
| Ford, LM; Kolmonpunporn, M; Norman, AB; Sanberg, PR | 1 |
| Fuji, K; Kameyama, T; Nabeshima, T; Yamada, K | 1 |
| Brauckmann, JL; Ford, LM; Giordano, M; Norman, AB; Sanberg, PR | 1 |
| Beal, MF; Ferrante, RJ; Kowall, NW; Martin, JB; Swartz, KJ | 1 |
| McGeer, EG; McGeer, PL; Zhu, SG | 1 |
| Chase, TN; Engber, TM; Susel, Z | 1 |
| Caccia, S; Conti, I; Samanin, R; Serafini, R; Stasi, MA; Tridico, RV; Vezzani, A | 1 |
| Foster, AC; Gill, R; Woodruff, GN | 1 |
| Chase, TN; Engber, TM | 1 |
| Fagg, GE; Massieu, L; McVey, M; Thedinga, KH | 1 |
| Johnston, MV; McDonald, JW; Trescher, WH | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Brotchi, J; Holemans, S; Levivier, M; Maloteaux, JM; Przedborski, S; Togasaki, DM | 1 |
| Carraro, S; Guarnieri, T; Villani, L; Virgili, M | 1 |
| Fedele, E; Foster, AC | 1 |
| Ríos, C; Santamaría, A | 1 |
| Altagracia, M; Flores, A; Kravzov, J; Rios, C; Santamaria, A | 1 |
| Du, F; Eid, T; Schwarcz, R | 1 |
| Geddes, JW; Pang, Z; Umberger, GH | 1 |
| Danysz, W; Frankiewicz, T; Misztal, M; Parsons, CG | 1 |
| Mary, V; Stutzmann, JM; Wahl, F | 1 |
| Beninger, RJ; Boegman, RJ; Flesher, S; Jhamandas, KH; Pawley, AC | 1 |
| Flores, A; Galván-Arzate, S; Osorio-Rico, L; Pérez, P; Ríos, C; Santamaría, A; Solís, F | 1 |
| Flores, A; Galván-Arzate, S; Pérez, P; Ríos, C; Santamaría, A | 1 |
| Martin, LJ; Portera-Cailliau, C; Price, DL | 1 |
| Carlock, LR; Shan, Y; Walker, PD | 1 |
| Levivier, M; Przedborski, S | 1 |
| Schmidt, WJ; Tzschentke, TM | 2 |
| Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y | 1 |
| Ginsberg, SD; Martin, LJ; Portera-Cailliau, C | 1 |
| Brum, LF; Elisabetsky, E; Souza, DO | 1 |
| Behan, WM; Stone, TW | 1 |
| Balcar, VJ; FitzGibbon, T; Pliss, L; St'astný, F | 1 |
| Block, F; Nolden-Koch, M; Schmidt, W; Schwarz, M | 1 |
| Camacho, A; Flores, A; Galván-Arzate, S; Jiménez-Capdeville, ME; Rodríguez-Martínez, E; Santamaría, A | 1 |
| Burgos, JS; Frizzo, ME; Lara, DR; Ramírez, G; Schmidt, AP; Souza, DO | 1 |
| Alves, LB; Emanuelli, T; Porciúncula, LO; Santos, CE; Souza, DO; Tasca, CI; Tavares, RG | 1 |
| Block, F; Frohn, C; Loos, M; Schwarz, M | 1 |
| Flumerfelt, BA; Hussain, N; Rajakumar, N | 1 |
| Bellé, NA; Dalmolin, GD; Fonini, G; Rocha, JB; Rubin, MA | 1 |
| Boeck, CR; Ganzella, M; Lottermann, A; Vendite, D | 1 |
| Nogueira, CW; Puntel, RL; Rocha, JB | 1 |
| Chetty, P; Dairam, A; Daya, S | 1 |
| Dutra Filho, CS; Grando, V; Ribeiro, CA; Wajner, M; Wannmacher, CM | 1 |
| Adams, S; Braidy, N; Brew, BJ; Grant, R; Guillemin, GJ | 1 |
| Antoniolli, E; Antunes, C; da Silva Filho, M; Kalinine, E; Portela, LV; Souza, DO; Torres, FV; Tort, AB | 1 |
| Kalonia, H; Kumar, A; Kumar, P; Nehru, B | 1 |
| Heimfarth, L; Loureiro, SO; Mello e Souza, T; Pessoa-Pureur, R; Pierozan, P; Silvestrin, RB; Soska, AK; Wajner, M; Zamoner, A | 1 |
| He, Y; Xiao, H; Yang, C; Zheng, N | 1 |
| Bissada, N; Gan, L; Graham, RK; Hayden, MR; Leavitt, BR; Liu, L; Lu, G; Mazarei, G; Metzler, M | 1 |
| Adams, S; Brew, BJ; Chung, R; Guillemin, GJ; Lee, MC; Ting, KK | 1 |
| Bastos, LL; Bridi, JC; Corte, CL; da Rocha, JB; de Ávila, DS; Dobrachinski, F; Soares, FA | 1 |
| An, SC; Chen, HB; Li, F; Wu, S | 1 |
| Braidy, N; Brew, BJ; Chung, R; Guillemin, GJ; Inestrosa, NC; Sachdev, P | 1 |
| Banister, SD; Guillemin, GJ; Karl, T; Kassiou, M; Lim, CK; Purves-Tyson, T; Weickert, CS; Zavitsanou, K | 1 |
| Biasibetti-Brendler, H; Ferreira, F; Pessoa-Pureur, R; Pierozan, P; Schmitz, F; Wyse, ATS | 1 |
| Biasibetti, H; Colín-González, AL; da Silva, JC; Pierozan, P; Santamaria, A; Wajner, M; Wyse, A | 1 |
69 other study(ies) available for quinolinic acid and dizocilpine maleate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Administration of quinolinic acid in the rat hippocampus induces expression of c-fos and NGFI-A.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Gene Expression Regulation; Genes, fos; Hippocampus; Ibotenic Acid; In Situ Hybridization; Injections, Intraperitoneal; Male; Oligonucleotide Probes; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
Application of magnetic resonance imaging to the measurement of neurodegeneration in rat brain: MRI data correlate strongly with histology and enzymatic analysis.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Arteries; Choline O-Acetyltransferase; Clinical Enzyme Tests; Constriction; Dizocilpine Maleate; Glutamate Decarboxylase; Ischemic Attack, Transient; Magnetic Resonance Imaging; Nerve Degeneration; Quinolinic Acid; Rats; Rats, Inbred F344 | 1992 |
Developmental changes in the effects of drugs acting at NMDA or non-NMDA receptors on synaptic transmission in the chick cochlear nucleus (nuc. magnocellularis).
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Chick Embryo; Cochlear Nerve; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electric Stimulation; Embryonic and Fetal Development; Evoked Potentials; Ibotenic Acid; N-Methylaspartate; Piperazines; Quinolinic Acid; Quinolinic Acids; Quinoxalines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
An investigation of the mechanisms of delayed neurodegeneration caused by direct injection of quinolinate into the rat striatum in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Anticonvulsants; Convulsants; Corpus Striatum; Dialysis; Diazepam; Dizocilpine Maleate; Glutamate Decarboxylase; Haloperidol; Ibotenic Acid; Injections; Male; Nerve Degeneration; Pipecolic Acids; Piperazines; Piperidines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Stereotaxic Techniques | 1991 |
Differential loss of neurochemical markers following quinolinic acid-induced lesions of rat striatum.
Topics: Animals; Benzazepines; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Male; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate | 1991 |
A lot of "excitement' about neurodegeneration.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aging; Alzheimer Disease; Animals; Dizocilpine Maleate; Haplorhini; Humans; Huntington Disease; Nerve Degeneration; Neurotoxins; Parkinson Disease; Quinolinic Acid; Quinolinic Acids; Receptors, Dopamine | 1991 |
Plasma and CSF levels of dizocilpine (MK-801) required for neuroprotection in the quinolinate-injected rat striatum.
Topics: Animals; Blood Proteins; Cerebrospinal Fluid Proteins; Corpus Striatum; Dizocilpine Maleate; Male; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Effects of MK-801, ketamine and alaptide on quinolinate models in the maturing hippocampus.
Topics: Animals; Cell Hypoxia; Dizocilpine Maleate; Hippocampus; Injections, Intraventricular; Ketamine; Male; Nerve Degeneration; Neuropeptides; Peptides, Cyclic; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1991 |
Neural grafts and pharmacological intervention in a model of Huntington's disease.
Topics: Acetylcholinesterase; Amphetamine; Animals; Brain Tissue Transplantation; Catalepsy; Cerebral Cortex; Corpus Striatum; Dizocilpine Maleate; Electron Transport Complex IV; Female; Fetal Tissue Transplantation; Huntington Disease; Immunohistochemistry; Kainic Acid; Motor Activity; Nerve Degeneration; Pregnancy; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1990 |
Chronic treatment with MK-801 increases the quinolinic acid-induced loss of D-1 dopamine receptors in rat striatum.
Topics: Animals; Benzazepines; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Drug Synergism; Kinetics; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Dopamine | 1990 |
Neurotoxicity induced by continuous infusion of quinolinic acid into the lateral ventricle in rats.
Topics: Animals; Brain; Cerebral Cortex; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Glutamate Decarboxylase; Hemicholinium 3; Hippocampus; Injections; Injections, Intraventricular; Male; Nervous System Diseases; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1990 |
MK801 prevents quinolinic acid-induced behavioral deficits and neurotoxicity in the striatum.
Topics: Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Feeding Behavior; Motor Activity; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1990 |
Systemic approaches to modifying quinolinic acid striatal lesions in rats.
Topics: 2-Amino-5-phosphonovalerate; Allopurinol; Amino Acids; Animals; Antioxidants; Baclofen; Corpus Striatum; Dibenzocycloheptenes; Disease Models, Animal; Dizocilpine Maleate; Huntington Disease; Ketamine; Male; Neuropeptide Y; Nimodipine; Peptides; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Substance P; Taurine; Valine | 1988 |
Effect of MK-801, kynurenate, glycine, dextrorphan and 4-acetylpyridine on striatal toxicity of quinolinate.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Dextrorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Glutamate Decarboxylase; Glycine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1989 |
Behavioral evaluation of the anti-excitotoxic properties of MK-801: comparison with neurochemical measurements.
Topics: Animals; Anticonvulsants; Apomorphine; Choline O-Acetyltransferase; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamate Decarboxylase; Male; Nervous System Diseases; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Stereotyped Behavior | 1989 |
Kinetics of MK-801 and its effect on quinolinic acid-induced seizures and neurotoxicity in rats.
Topics: Animals; Anticonvulsants; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Electroencephalography; Male; Prazosin; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Seizures | 1989 |
Neuroprotective effects of MK-801 in vivo: selectivity and evidence for delayed degeneration mediated by NMDA receptor activation.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Animals; Aspartic Acid; Brain; Dibenzocycloheptenes; Dizocilpine Maleate; Ibotenic Acid; Isoflurane; Kainic Acid; Male; N-Methylaspartate; Nerve Degeneration; Piperazines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Time Factors | 1988 |
Dextromethorphan does not protect against quinolinic acid neurotoxicity in rat striatum.
Topics: Animals; Choline O-Acetyltransferase; Corpus Striatum; Dextromethorphan; Dibenzocycloheptenes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Levorphanol; Male; Movement Disorders; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1988 |
A comparative analysis of the neuroprotective properties of competitive and uncompetitive N-methyl-D-aspartate receptor antagonists in vivo: implications for the process of excitotoxic degeneration and its therapy.
Topics: 2-Amino-5-phosphonovalerate; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biomarkers; Cell Death; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Drug Administration Schedule; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Injections; Injections, Intraperitoneal; Kainic Acid; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neurotoxins; Pipecolic Acids; Piperazines; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1993 |
Quinolinate-induced injury is enhanced in developing rat brain.
Topics: Age Factors; Animals; Carbamazepine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Male; Neostriatum; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 mRNAs in adult rat brain after intrahippocampal injection of quinolinic acid.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Dizocilpine Maleate; Gene Expression Regulation; Hippocampus; In Situ Hybridization; Male; Microinjections; Nerve Growth Factors; Nerve Tissue Proteins; Neurotrophin 3; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Reference Values; RNA, Messenger | 1994 |
Quantitative assessment of quinolinic acid-induced striatal toxicity in rats using radioligand binding assays.
Topics: Animals; Dizocilpine Maleate; Male; Neostriatum; Neuroglia; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Scopolamine | 1994 |
Quinolinic acid but not MK-801 protects the dopaminergic system from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced toxicity in goldfish retina.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dopamine; Goldfish; Microscopy, Electron; MPTP Poisoning; Necrosis; Neurons; Photoreceptor Cells; Quinolinic Acid; Retina | 1994 |
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine | 1993 |
MK-801, an N-methyl-D-aspartate receptor antagonist, blocks quinolinic acid-induced lipid peroxidation in rat corpus striatum.
Topics: Animals; Cell Death; Corpus Striatum; Dizocilpine Maleate; Lipid Peroxidation; Male; Neurons; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence; Thiobarbituric Acid Reactive Substances | 1993 |
Protective effect of probenecid on circling behavior of rats with unilateral quinollinic acid induced striatal lesions.
Topics: Animals; Apomorphine; Corpus Striatum; Dizocilpine Maleate; Male; Probenecid; Quinolinic Acid; Rats; Rats, Wistar; Stereotyped Behavior | 1993 |
Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region.
Topics: Aminooxyacetic Acid; Animals; Behavior, Animal; Dizocilpine Maleate; Entorhinal Cortex; Excitatory Amino Acid Antagonists; GABA Agents; Hippocampus; Injections; Male; Neurons; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1995 |
Neuronal loss and cytoskeletal disruption following intrahippocampal administration of the metabolic inhibitor malonate: lack of protection by MK-801.
Topics: Animals; Cell Death; Cytoskeleton; Dizocilpine Maleate; Dose-Response Relationship, Drug; Hippocampus; Injections; Male; Malonates; Neurons; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Succinate Dehydrogenase; Time Factors | 1996 |
Learning deficits induced by chronic intraventricular infusion of quinolinic acid--protection by MK-801 and memantine.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Dopamine Agents; Hippocampus; Injections, Intraventricular; Learning Disabilities; Male; Maze Learning; Memantine; Memory, Short-Term; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission.
Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Neurons; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Riluzole; Synaptic Transmission; Thiazoles; Triazines | 1995 |
Differential action of NMDA antagonists on cholinergic neurotoxicity produced by N-methyl-D-aspartate and quinolinic acid.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Brain; Choline O-Acetyltransferase; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Antagonism; Excitatory Amino Acid Antagonists; Kynurenic Acid; Male; N-Methylaspartate; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Quinolinic acid neurotoxicity: in vivo increased copper and manganese content in rat corpus striatum after quinolinate intrastriatal injection.
Topics: Analysis of Variance; Animals; Chromatography, High Pressure Liquid; Copper; Corpus Striatum; Dizocilpine Maleate; gamma-Aminobutyric Acid; Male; Manganese; Neuroglia; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spectrophotometry, Atomic | 1996 |
Changes in transition metal contents in rat brain regions after in vivo quinolinate intrastriatal administration.
Topics: Animals; Cerebellum; Copper; Dizocilpine Maleate; Hippocampus; Male; Manganese; Mesencephalon; Metals; Quinolinic Acid; Rats; Rats, Wistar; Telencephalon | 1996 |
Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum.
Topics: Animals; Apoptosis; Brain; Cell Death; Dizocilpine Maleate; Kainic Acid; Male; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate | 1997 |
NMDA receptor overstimulation triggers a prolonged wave of immediate early gene expression: relationship to excitotoxicity.
Topics: Animals; Calcium; Corpus Striatum; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth Response Protein 1; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Immediate-Early Proteins; Male; Nerve Degeneration; Nerve Tissue Proteins; Neurons; Neuropeptides; Neurotoxins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinolinic Acid; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic | 1997 |
Quinolinic acid-induced lesions of the rat striatum: quantitative autoradiographic binding assessment.
Topics: Animals; Autoradiography; Benzazepines; Binding, Competitive; Cholinergic Agents; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Hemicholinium 3; Huntington Disease; Isoquinolines; Male; Mazindol; Muscarinic Antagonists; Neurons; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Scopolamine; Sulpiride; Tritium | 1998 |
Discrete quinolinic acid lesions of the rat prelimbic medial prefrontal cortex affect cocaine- and MK-801-, but not morphine- and amphetamine-induced reward and psychomotor activation as measured with the place preference conditioning paradigm.
Topics: Amphetamine; Analgesics, Opioid; Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Male; Morphine; Motor Activity; Prefrontal Cortex; Psychomotor Performance; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reward | 1998 |
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes | 1999 |
Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum.
Topics: Animals; Denervation; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Hippocampus; Kainic Acid; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Septum Pellucidum | 1999 |
Anticonvulsant properties of linalool in glutamate-related seizure models.
Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Glutamic Acid; Kindling, Neurologic; Male; Monoterpenes; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Seizures; Terpenes | 1999 |
Differential effects of quinolinic acid lesions of the medial prefrontal cortex on the expression of morphine- and dizocilpine- induced behavioural plasticity in the rat.
Topics: Analysis of Variance; Animals; Dizocilpine Maleate; Drug Interactions; Drug Tolerance; Factor Analysis, Statistical; Male; Morphine; Motor Activity; Prefrontal Cortex; Quinolinic Acid; Rats; Rats, Sprague-Dawley | 2000 |
Role of kynurenines in the neurotoxic actions of kainic acid.
Topics: Alanine; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Hippocampus; Kainic Acid; Kynurenine; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Neurotoxicity of NAAG in vivo is sensitive to NMDA antagonists and mGluR II ligands.
Topics: Animals; Cell Death; Cerebral Ventricles; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Injections, Intraventricular; Ligands; Male; Neurons; Neurotoxins; Pipecolic Acids; Quinolinic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2000 |
Rolipram reduces excitotoxic neuronal damage.
Topics: Animals; Antidepressive Agents; Cell Count; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Immunohistochemistry; Male; Neostriatum; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Wistar; Rolipram; Tumor Necrosis Factor-alpha | 2001 |
In vivo hydroxyl radical formation after quinolinic acid infusion into rat corpus striatum.
Topics: Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutathione; Glutathione Peroxidase; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Male; Microdialysis; Microinjections; Neuroprotective Agents; Nitro Compounds; Oxidative Stress; Perfusion; Propionates; Quinolinic Acid; Rats; Rats, Wistar; Salicylic Acid; Wakefulness | 2001 |
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venoms; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine; Kainic Acid; Male; Mice; Neuroprotective Agents; Phenobarbital; Phosphodiesterase Inhibitors; Quinolinic Acid; Receptors, Purinergic P1 | 2001 |
Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes.
Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 2002 |
Association between inflammation and nigral neuronal damage following striatal excitotoxic lesion.
Topics: Animals; Brain Diseases; Cell Count; Chondroitin Sulfate Proteoglycans; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Functional Laterality; Glial Fibrillary Acidic Protein; Immunohistochemistry; Inflammation; Keratan Sulfate; Lumican; Male; Phosphodiesterase Inhibitors; Phosphopyruvate Hydratase; Quinolinic Acid; Rats; Rats, Wistar; Rolipram; Substantia Nigra; Time Factors; Tumor Necrosis Factor-alpha | 2004 |
Glutamatergic regulation of long-term grafts of fetal lateral ganglionic eminence in a rat model of Huntington's disease.
Topics: Animals; Brain Injuries; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Fetal Tissue Transplantation; Fluorescent Antibody Technique; Glutamine; Haloperidol; Huntington Disease; Immunohistochemistry; Male; Neurons, Afferent; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate | 2004 |
Polyamines reduces lipid peroxidation induced by different pro-oxidant agents.
Topics: Animals; Antioxidants; Biguanides; Biogenic Polyamines; Dizocilpine Maleate; Edetic Acid; Iron; Lipid Peroxidation; Nitroprusside; Oxidants; Quinolinic Acid; Rats; Rats, Wistar; Spermidine; Spermine; Thiobarbituric Acid Reactive Substances | 2004 |
NMDA preconditioning protects against seizures and hippocampal neurotoxicity induced by quinolinic acid in mice.
Topics: Animals; Apoptosis; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Hippocampus; Humans; Male; Mice; Motor Activity; N-Methylaspartate; Neurons; Neurotoxicity Syndromes; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Seizures | 2004 |
N-methyl-D-aspartate receptors are involved in the quinolinic acid, but not in the malonate pro-oxidative activity in vitro.
Topics: Animals; Brain Chemistry; Chelating Agents; Deoxyribose; Dizocilpine Maleate; Electron Transport; Lipid Peroxidation; Malonates; Oxidation-Reduction; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Succinate Dehydrogenase; Thiobarbituric Acid Reactive Substances | 2005 |
Non-steroidal anti-inflammatory agents, tolmetin and sulindac, attenuate oxidative stress in rat brain homogenate and reduce quinolinic acid-induced neurodegeneration in rat hippocampal neurons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Hippocampus; Kinetics; Lipid Peroxidation; Male; Nerve Degeneration; Neurons; Neuroprotective Agents; Oxidative Stress; Potassium Chloride; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sulindac; Superoxides; Thermodynamics; Tolmetin | 2006 |
Evidence that quinolinic acid severely impairs energy metabolism through activation of NMDA receptors in striatum from developing rats.
Topics: Animals; Animals, Newborn; Carbon Dioxide; Carbon Isotopes; Corpus Striatum; Creatine Kinase; Dizocilpine Maleate; Drug Interactions; Electron Transport; Electron Transport Chain Complex Proteins; Energy Metabolism; Excitatory Amino Acid Antagonists; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors | 2006 |
Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons.
Topics: Alcohol Dehydrogenase; Analysis of Variance; Astrocytes; Brain; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; L-Lactate Dehydrogenase; Memantine; Microtubule-Associated Proteins; Neurons; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Poly(ADP-ribose) Polymerases; Quinolinic Acid | 2009 |
Electrophysiological effects of guanosine and MK-801 in a quinolinic acid-induced seizure model.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Guanosine; Male; Quinolinic Acid; Rats; Rats, Wistar; Seizures; Spectrum Analysis; Theta Rhythm | 2010 |
Neuroprotective effect of MK-801 against intra-striatal quinolinic acid induced behavioral, oxidative stress and cellular alterations in rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Dizocilpine Maleate; Male; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar | 2009 |
Acute intrastriatal administration of quinolinic acid provokes hyperphosphorylation of cytoskeletal intermediate filament proteins in astrocytes and neurons of rats.
Topics: Analysis of Variance; Animals; Astrocytes; Blotting, Western; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Dizocilpine Maleate; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Microinjections; Neurofilament Proteins; Neurons; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phosphorylation; Quinolinic Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate | 2010 |
Neurotoxicity of quinolinic acid to spiral ganglion cells in rats.
Topics: Animals; Animals, Newborn; Apoptosis; Calcium; Cells, Cultured; Dizocilpine Maleate; Hearing Loss, Sensorineural; Magnesium Chloride; Otitis Media with Effusion; Quinolinic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Spiral Ganglion | 2010 |
Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Corpus Striatum; Dizocilpine Maleate; Dopamine and cAMP-Regulated Phosphoprotein 32; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Huntingtin Protein; Male; Mice; Mutation; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Quinolinic Acid; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques | 2010 |
Characterisation of the expression of NMDA receptors in human astrocytes.
Topics: Adult; Astrocytes; Brain; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Gene Expression Profiling; Glutamic Acid; Humans; Immunohistochemistry; L-Lactate Dehydrogenase; Memantine; Microscopy, Confocal; Protein Subunits; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Cooperation of non-effective concentration of glutamatergic system modulators and antioxidant against oxidative stress induced by quinolinic acid.
Topics: Animals; Antioxidants; Benzene Derivatives; Brain Chemistry; Cell Survival; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine; Indicators and Reagents; Lipid Peroxidation; Male; Nerve Tissue Proteins; Organoselenium Compounds; Oxidants; Oxidative Stress; Quinolinic Acid; Rats; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2012 |
[Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression].
Topics: Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stress, Psychological | 2013 |
Changes in Cathepsin D and Beclin-1 mRNA and protein expression by the excitotoxin quinolinic acid in human astrocytes and neurons.
Topics: Apoptosis Regulatory Proteins; Astrocytes; Beclin-1; Cathepsin D; Cells, Cultured; Dizocilpine Maleate; Humans; Membrane Proteins; Neurons; Neuroprotective Agents; Neurotoxins; Quinolinic Acid | 2014 |
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: amelioration by COX-2 inhibition.
Topics: Animals; Brain; Celecoxib; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Female; Gestational Age; Hyperkinesis; Kynurenic Acid; Kynurenine; Male; Picolinic Acids; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Quinolinic Acid; Random Allocation; Rats; Rats, Wistar; Schizophrenia; Sexual Maturation; Sulfonamides; Tryptophan | 2014 |
Kynurenic Acid Prevents Cytoskeletal Disorganization Induced by Quinolinic Acid in Mixed Cultures of Rat Striatum.
Topics: Animals; Antioxidants; Astrocytes; Cell Communication; Cells, Cultured; Corpus Striatum; Cytoskeleton; Dizocilpine Maleate; Gap Junctions; Kynurenic Acid; Microglia; Models, Biological; N-Methylaspartate; Neurons; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Toxic Synergism Between Quinolinic Acid and Glutaric Acid in Neuronal Cells Is Mediated by Oxidative Stress: Insights to a New Toxic Model.
Topics: Animals; Antioxidants; Catalase; Cell Survival; Cerebral Cortex; Coculture Techniques; Dizocilpine Maleate; Female; Gliosis; Glutarates; Glutathione; Melatonin; Models, Biological; Neostriatum; Neurites; Neurons; Oxidative Stress; Quinolinic Acid; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase | 2018 |