quinoline-3-carboxamide and 4-hydroxy-5-nitrophenyl-acetic-acid

The effect of a quinoline-3-carboxamide on the T cell-dependent B cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal centre (GC) B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of GCs formed and their size were reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response, there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive.

Topics: Animals; B-Lymphocytes; Cells, Cultured; Chickens; gamma-Globulins; Germinal Center; Haptens; Immunity, Humoral; Immunization; Immunoglobulin G; Immunomodulation; Lymphocyte Count; Mice; Mice, Inbred C57BL; Nitrophenols; Phenylacetates; Quinolines; Spleen; T-Lymphocytes