quinidine has been researched along with piperidines in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (50.00) | 18.7374 |
| 1990's | 14 (20.59) | 18.2507 |
| 2000's | 12 (17.65) | 29.6817 |
| 2010's | 5 (7.35) | 24.3611 |
| 2020's | 3 (4.41) | 2.80 |
| Authors | Studies |
|---|---|
| Petersen, EN | 1 |
| Grundke, M; Ravens, U; Wettwer, E | 1 |
| Kanno, M; Nakaya, H; Oyama, Y; Shishido, Y | 1 |
| Farmer, C; Fifield, J; Hodges, M; Salerno, DM | 1 |
| Kuang, Y; Liu, TP | 1 |
| Hahn, EW; Osswald, H; Pommerenke, EW; Volm, M | 1 |
| Keefe, DL; Miura, D; Somberg, JC | 1 |
| Somberg, J | 1 |
| Roden, DM; Siddoway, LA; Woosley, RL | 1 |
| Roy, D | 1 |
| Echt, DS; Roden, DM; Woosley, RL | 1 |
| Morganroth, J; Nestico, PF | 1 |
| Huang, SK; Marcus, FI | 1 |
| Light, RT; Onrot, J; Robertson, D; Robertson, RM; Tantengco, MV | 1 |
| Borgeat, A; Goy, JJ; Grbic, M; Kaufmann, U; Maendly, R; Sigwart, U | 1 |
| Podrid, PJ | 1 |
| Collignon, P; Legrand, V | 1 |
| Atarashi, H; Hayakawa, H | 1 |
| Alps, BJ; Borrows, ET; Johnson, ES; Staniforth, MW; Wilson, AB | 1 |
| Alps, BJ; Fidler, K; Hill, M; Johnson, ES; Wilson, AB | 1 |
| Casagrande, C; Ferrari, G; Ferrini, R; Galli, A; Miragoli, G | 1 |
| Guérémy, C; Tamen, JC; Uzan, A | 1 |
| Dungan, KW; Dykstra, SJ; Ferguson, HC; Lawson, JE; Minielli, JL | 1 |
| Gates, M; Schreiber, WL; Sugavanam, B | 1 |
| Cheymol, G; Duteil, J; Olive, G | 1 |
| Schmitz, W | 1 |
| Hillis, WS; Whiting, B | 1 |
| Somberg, JC | 1 |
| Doherty, JU; Josephson, ME; Kienzle, MG; Williams, PD; Zygmont, D | 1 |
| Bricaud, H; Castagne, D; Clémenty, J; Dallocchio, M | 1 |
| Granrud, G; Hodges, M; Salerno, DM; Sharkey, P | 1 |
| Granrud, G; Hodges, M; Salerno, DM | 1 |
| Falk, RH; O'Brien, JL | 1 |
| Block, PJ; Winkle, RA | 1 |
| Kates, RE | 1 |
| Banitt, EH; Kvam, DC; Schmid, JR | 1 |
| Cohn, PF; Mallis, GI; Singh, S; Vlay, SC | 1 |
| Antonin, KH; Bieck, PR; Feifel, N; Fuchs, L; Gleiter, CH; Jedrychowski, M; Kucher, K; Schmidt, E | 1 |
| Hill, BT; Hosking, LK | 1 |
| Ishii, K; Taira, N; Yamagishi, T | 1 |
| Chow, MS; Fisher, JR; Kluger, J; Tisdale, JE | 1 |
| Almotrefi, AA | 1 |
| Cayen, MN; Chen, KJ; Clement, RP; Huie, K; Snow, M; Yumibe, N | 1 |
| Asano, Y; Baxter, WT; Davidenko, JM; Gray, RA; Jalife, J | 1 |
| Allard, P; Norlén, M | 1 |
| France, CP; Lelas, S; Otton, SV; Sellers, EM; Wegert, S | 1 |
| Danilo, P; de Groot, JR; Feinmark, S; Gainullin, R; Plotnikov, AN; Rosen, MR; Rosenshtraukh, L; Shvilkin, A; Xiong, W | 1 |
| Bible, KC; Boerner, SA; Kaufmann, SH; Tourne, ME | 1 |
| Fukuda, K; Kato, T; Kodama, H; Miyoshi, S; Ogawa, S; Tahara, S | 1 |
| Brown, AM; Ficker, E; Obejero-Paz, CA; Zhao, S | 1 |
| Colas, A; Pages, N; Sauviat, MP | 1 |
| Bidstrup, TB; Brøsen, K; Damkier, P; Scharling, B; Stilling, N; Thomsen, MS | 1 |
| Black, ML; Duncan, JN; Toth, LN; Yamazaki, S | 1 |
| Pan, YP; Wang, XL; Xu, XH | 1 |
| Chan, AP; Guppy, LJ; Leung, MW; So, PP; Walker, MJ | 1 |
| Abe, J; Hamada, Y; Harada, T; Hashimoto, K; Horii, I; Sawada, Y; Shiotani, M | 1 |
| Bidstrup, TB; Brøsen, K; Damkier, P; Ekblom, M; Karlsson, A; Olsen, AK | 1 |
| Dirson, G; Farinotti, R; Fernandez, C; German-Fattal, M; Gimenez, F; Hindlet, P; Roux, F | 1 |
| LOCKETT, MF | 1 |
| Fuse, E; Kodaira, H; Kusuhara, H; Sugiyama, Y; Ushiki, J | 1 |
| Dinter-Heidorn, H; Greupink, R; Koenderink, JB; Russel, FG; van den Broek, PH; van den Heuvel, JJ; Wittgen, HG | 1 |
| Ma, J; Song, Z; Wang, J; Wang, S; Wang, X; Zhao, Q | 1 |
| Luo, C; Wang, K; Zhang, H | 2 |
| Hayashi, M; Hirasawa-Inoue, A; Matsumoto, N; Matsumura, Y; Mizuguchi, T; Shirai, K; Sugai, K; Takase, C; Watanabe, A; Watanabe, T | 1 |
| Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N | 1 |
| Anderson, MS; Bertz, R; Bhardwaj, R; Collins, JL; Coric, V; Croop, R; Finley, JA; Madonia, J; Stock, DA; Stringfellow, J | 1 |
11 review(s) available for quinidine and piperidines
| Article | Year |
|---|---|
The treatment of ventricular rhythm disturbances.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil | 1986 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Clinical pharmacology of old and new antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide | 1985 |
Antiarrhythmic drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1986 |
Effects of congestive heart failure on the pharmacokinetics and pharmacodynamics of antiarrhythmic agents.
Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Digitalis; Disopyramide; Drug Interactions; Encainide; Flecainide; Half-Life; Heart Failure; Hemodynamics; Humans; Kidney; Kinetics; Lidocaine; Liver; Piperidines; Plants, Medicinal; Plants, Toxic; Potassium; Procainamide; Quinidine; Regional Blood Flow; Tocainide | 1986 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil | 1986 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Quinidine; Sodium; Tocainide | 1980 |
Antiarrhythmic drug therapy for sustained ventricular tachycardia.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bethanidine; Calcium Channel Blockers; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Encainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Phenytoin; Piperidines; Procainamide; Quinidine; Tachycardia; Tocainide | 1984 |
Hemodynamic effects of antiarrhythmic drugs.
Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide | 1983 |
Metabolites of cardiac antiarrhythmic drugs: their clinical role.
Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Disopyramide; Encainide; Humans; Lidocaine; Piperidines; Procainamide; Quinidine | 1984 |
11 trial(s) available for quinidine and piperidines
| Article | Year |
|---|---|
Pirmenol: an antiarrhythmic drug with unique electrocardiographic features--a double-blind placebo-controlled comparison with quinidine.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Double-Blind Method; Electrocardiography; Female; Humans; Male; Middle Aged; Piperidines; Quinidine; Stroke Volume | 1991 |
Flecainide versus quinidine for conversion of atrial fibrillation to sinus rhythm.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Trials as Topic; Female; Flecainide; Heart; Heart Rate; Humans; Male; Middle Aged; Piperidines; Quinidine; Radiography | 1986 |
[Comparative study of a slow-release quinidine preparation and flecainide administered in 2 daily doses for the treatment of extrasystole].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Delayed-Action Preparations; Drug Administration Schedule; Electrocardiography; Female; Flecainide; Humans; Male; Middle Aged; Monitoring, Physiologic; Piperidines; Quinidine | 1984 |
Flecainide versus quinidine for treatment of chronic ventricular arrhythmias. A multicenter clinical trial.
Topics: Administration, Oral; Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Flecainide; Heart Ventricles; Humans; Male; Middle Aged; Piperidines; Quinidine; Random Allocation; Tachycardia | 1983 |
Comparison of flecainide with quinidine for suppression of chronic stable ventricular ectopic depolarizations. A double-blind randomized study in ambulatory outpatients.
Topics: Adult; Aged; Ambulatory Care; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Flecainide; Heart Ventricles; Humans; Male; Middle Aged; Piperidines; Quinidine; Random Allocation | 1983 |
Flecainide versus quinidine: results of a multicenter trial.
Topics: Adult; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Electrocardiography; Flecainide; Humans; Piperidines; Quinidine; Random Allocation | 1984 |
Lorcainide. A comparative trial with quinidine gluconate in patients with previously untreated ventricular arrhythmias.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzeneacetamides; Clinical Trials as Topic; Female; Heart Ventricles; Humans; Male; Middle Aged; Piperidines; Quinidine; Random Allocation | 1984 |
Comparison of lorcainide and quinidine in the treatment of ventricular ectopy.
Topics: Adult; Aged; Arrhythmias, Cardiac; Benzeneacetamides; Female; Humans; Male; Middle Aged; Piperidines; Quinidine; Tachycardia | 1984 |
Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carbamates; Chromatography, High Pressure Liquid; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Induction; Humans; Hydrocortisone; Hypoglycemic Agents; Male; Middle Aged; Piperidines; Quinidine; Rifampin; Time Factors | 2004 |
The impact of CYP2C8 polymorphism and grapefruit juice on the pharmacokinetics of repaglinide.
Topics: Administration, Oral; Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Blood Glucose; Carbamates; Citrus paradisi; Cross-Over Studies; Cytochrome P-450 CYP2C8; Genotype; Humans; Hypoglycemic Agents; Male; Piperidines; Polymorphism, Genetic; Quinidine | 2006 |
P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects.
Topics: ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cross-Over Studies; Cyclosporine; Female; Healthy Volunteers; Humans; Membrane Transport Proteins; Neoplasm Proteins; Piperidines; Pyridines; Quinidine | 2022 |
46 other study(ies) available for quinidine and piperidines
| Article | Year |
|---|---|
Experimental anti-arrhythmic properties of melperone, a neuroleptic butyrophenone.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Butyrophenones; Droperidol; Epinephrine; Guinea Pigs; Lidocaine; Male; Ouabain; Piperidines; Procainamide; Propranolol; Quinidine; Rabbits; Rats | 1978 |
Differential effects of the new class III antiarrhythmic agents almokalant, E-4031 and D-sotalol, and of quinidine, on delayed rectifier currents in guinea pig ventricular myocytes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Guinea Pigs; In Vitro Techniques; Muscles; Piperidines; Potassium; Potassium Channels; Propanolamines; Pyridines; Quinidine; Sotalol; Time Factors | 1992 |
Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Mexiletine; Microelectrodes; Neuromuscular Depolarizing Agents; Papillary Muscles; Piperidines; Propylamines; Pyridines; Quinidine; Sodium Channels | 1992 |
Rate-dependent depression of maximal rate of depolarization in guinea pig papillary muscle action potentials by changrolin.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Female; Guinea Pigs; In Vitro Techniques; Male; Mexiletine; Papillary Muscles; Piperidines; Quinazolines; Quinidine | 1990 |
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells.
Topics: Animals; Drug Resistance; Ethylamines; Hycanthone; Leukemia L1210; Phenotype; Piperidines; Quinidine; Quinine; Tamoxifen; Trifluoperazine; Verapamil | 1990 |
Orthostatic hypotension: clinical spectrum and approach to treatment.
Topics: Adult; Aged; Amiodarone; Disopyramide; Female; Flecainide; Humans; Hypotension, Orthostatic; Lidocaine; Male; Middle Aged; Piperidines; Procainamide; Quinidine; Sympathomimetics; Tocainide | 1986 |
Aggravation of ventricular arrhythmia. A drug-induced complication.
Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine | 1985 |
Haemodynamic effects of class I antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide | 1985 |
[Anti-arrhythmia agents (I): Quinidine, procainamide, disopyramide, encainide, propafenone and flecainide].
Topics: Anilides; Anti-Arrhythmia Agents; Disopyramide; Encainide; Flecainide; Humans; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine | 1985 |
A comparison of the cardiovascular actions of indoramin, propranolol, lignocaine, and quinidine.
Topics: Amides; Angiotensin II; Animals; Blood Pressure; Cats; Depression, Chemical; Epinephrine; Female; Heart; Heart Rate; Hemodynamics; Indoles; Isoproterenol; Lidocaine; Male; Muscle Contraction; Norepinephrine; Piperidines; Propranolol; Quinidine; Vascular Resistance | 1972 |
The reversal of experimental cardiac arrhythmias by indoramin (Wy 21901).
Topics: Amides; Anesthetics, Local; Animals; Arrhythmia, Sinus; Arrhythmias, Cardiac; Blood Pressure; Cats; Epinephrine; Female; Guinea Pigs; Halothane; Ileum; In Vitro Techniques; Indoles; Lidocaine; Male; Muscle Contraction; Nicotine; Ouabain; Piperidines; Procaine; Propranolol; Quinidine; Tachycardia; Ventricular Fibrillation | 1971 |
Synthesis and antiarrhythmic activity of 5,5-disubstituted-3-aminoalkylhydantions and some heterocyclic and noncyclic analogues.
Topics: Alkylation; Amides; Animals; Arrhythmias, Cardiac; Diethylamines; Dimethylamines; Disopyramide; Heterocyclic Compounds; Hydantoins; Isomerism; Mice; Piperidines; Quinidine; Structure-Activity Relationship; Urea; Ventricular Fibrillation | 1974 |
[Viquidil: study of metabolism using the isotope method. I. Synthesis of 14C-labelled viquidil].
Topics: Aldehydes; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Isomerism; Ketones; Oxidation-Reduction; Piperidines; Quinidine; Quinolines; Spectrum Analysis; Vasodilator Agents; Vinyl Compounds | 1972 |
Lysergic acid and quinidine analogs. 2-(o-Acylaminophenethyl)piperidines.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Ergolines; Female; Heart Rate; In Vitro Techniques; Mice; Muscle Contraction; Piperidines; Quinidine; Rats; Serotonin Antagonists; Spasm; Structure-Activity Relationship; Uterus | 1973 |
Syntheses in the cinchona alkaloid series.
Topics: Chemical Phenomena; Chemistry; Cinchona; Piperidines; Plants, Medicinal; Quinidine | 1970 |
[Anti-arrhythmic property of a derivative of propiophenone].
Topics: Aconitum; Animals; Barium; Dogs; Electric Stimulation; Epinephrine; Ethers; Guinea Pigs; Heart Atria; Heart Rate; Ouabain; Petroleum; Piperidines; Propiophenones; Quinidine; Rabbits | 1967 |
Antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil | 1983 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
Antiarrhythmic and electrophysiologic actions of flecainide in animal models.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dogs; Electrophysiology; Flecainide; Heart Conduction System; In Vitro Techniques; Lidocaine; Piperidines; Procainamide; Quinidine; Rabbits | 1984 |
Role of cytochrome P4502D6 in the metabolism of brofaromine. A new selective MAO-A inhibitor.
Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Female; Humans; Male; Mixed Function Oxygenases; Monoamine Oxidase Inhibitors; Phenotype; Piperidines; Quinidine | 1993 |
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance.
Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Flunarizine; Humans; Leukemia, T-Cell; Piperidines; Quinidine; Teniposide; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Cloning, Molecular; Electrophysiology; Myocardium; Oocytes; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Quinidine; Sotalol; Xenopus laevis | 1993 |
Efficacy of class 1C antiarrhythmic agents in patients with inducible ventricular tachycardia refractory to therapy with class 1A antiarrhythmic drugs.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Benzeneacetamides; Electric Stimulation; Encainide; Female; Flecainide; Humans; Male; Middle Aged; Piperidines; Quinidine; Retrospective Studies; Stroke Volume; Tachycardia, Ventricular | 1993 |
Effects of class I antiarrhythmic drugs on mitochondrial ATPase activity in guinea pig heart preparations.
Topics: Adenosine Triphosphatases; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Chemical Phenomena; Chemistry, Physical; Guinea Pigs; In Vitro Techniques; Lidocaine; Mitochondria, Heart; Piperidines; Quinidine | 1993 |
Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
Topics: Anti-Bacterial Agents; Antifungal Agents; Antimalarials; Binding Sites; Biotransformation; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Ketoconazole; Loratadine; Microsomes, Liver; Mixed Function Oxygenases; Models, Molecular; Oxidation-Reduction; Piperidines; Pyridines; Quinidine; Recombinant Proteins; Substrate Specificity; Troleandomycin | 1996 |
Optical mapping of drug-induced polymorphic arrhythmias and torsade de pointes in the isolated rabbit heart.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Heart; Heart Conduction System; Image Processing, Computer-Assisted; Models, Cardiovascular; Organ Culture Techniques; Perfusion; Piperidines; Pyridines; Quinidine; Rabbits; Torsades de Pointes | 1997 |
[3H]GBR 12935 binding in platelets: a possible association with cytochrome P-450IID6?
Topics: Antipsychotic Agents; Blood Platelets; Culture Techniques; Cytochrome P-450 Enzyme System; Dopamine Antagonists; Enzyme Inhibitors; Flupenthixol; Humans; Ligands; Lobeline; Piperazines; Piperidines; Quinidine | 1997 |
Inhibitors of cytochrome P450 differentially modify discriminative-stimulus and antinociceptive effects of hydrocodone and hydromorphone in rhesus monkeys.
Topics: Analgesics, Opioid; Animals; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Discrimination Learning; Enzyme Inhibitors; Female; Hydrocodone; Hydromorphone; Macaca mulatta; Pain Measurement; Piperidines; Quinidine; Receptors, Opioid, mu | 1999 |
Interactions between antiarrhythmic drugs and cardiac memory.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dogs; Electrocardiography; Electrophysiology; Feedback; Lidocaine; Piperidines; Potassium Channels; Pyridines; Quinidine | 2001 |
Effect of P-glycoprotein on flavopiridol sensitivity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; CHO Cells; Cisplatin; Colchicine; Colony-Forming Units Assay; Cricetinae; Drug Resistance, Multiple; Flavonoids; Paclitaxel; Piperidines; Quinidine; Verapamil | 2001 |
Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channels, L-Type; Cells, Cultured; Cytochalasin D; Drug Evaluation, Preclinical; ErbB Receptors; Focal Adhesion Kinase 2; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Piperidines; Potassium Channel Blockers; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Quinidine; Rats; Rats, Wistar; Tetraethylammonium; Time Factors; Tyrphostins | 2001 |
The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations.
Topics: Anti-Arrhythmia Agents; Astemizole; Benzimidazoles; Binding Sites; Blotting, Western; Cation Transport Proteins; Cell Line; Cell Membrane; Cisapride; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electrophysiology; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Inhibitory Concentration 50; Ions; Long QT Syndrome; Models, Chemical; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Folding; Pyridines; Quaternary Ammonium Compounds; Quinidine; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2002 |
Does lindane (gamma-hexachlorocyclohexane) increase the rapid delayed rectifier outward K+ current (IKr) in frog atrial myocytes?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Delayed Rectifier Potassium Channels; Electrophysiology; Heart Atria; Hexachlorocyclohexane; Myocardium; Myocytes, Cardiac; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quinidine; Ranidae | 2002 |
Comparison of prediction methods for in vivo clearance of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, a dopamine D2 receptor antagonist, in humans.
Topics: Adult; Animals; Chromatography, Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dogs; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Drug Interactions; Female; Haloperidol; Hepatocytes; Humans; Injections, Intravenous; Ketoconazole; Macaca fascicularis; Male; Metabolic Clearance Rate; Middle Aged; Piperidines; Quinidine; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Species Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfones | 2004 |
[High throughput screening method of potassium channel regulators].
Topics: 4-Aminopyridine; Animals; Barbiturates; Calcium Channel Blockers; Cromakalim; Isoxazoles; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; PC12 Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinidine; Rats | 2004 |
Effects of E4031 and quinidine on atrial and ventricular refractoriness in rabbits in vivo.
Topics: Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Blood Pressure; Dose-Response Relationship, Drug; Evoked Potentials; Heart Atria; Heart Ventricles; Piperidines; Pyridines; Quinidine; Rabbits; Refractory Period, Electrophysiological; Sinoatrial Node | 2004 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; Electrocardiography; Guinea Pigs; Haloperidol; Heart; Humans; Injections, Intravenous; Long QT Syndrome; Male; Nifedipine; Pimozide; Piperidines; Pyridines; Quinidine; Reproducibility of Results; Telemetry; Terfenadine; Thioridazine | 2005 |
Efavirenz does not interact with the ABCB1 transporter at the blood-brain barrier.
Topics: Alkynes; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzoxazines; Blood-Brain Barrier; Brain; Cell Line; Cyclopropanes; Cyclosporins; Digoxin; Endothelial Cells; Male; Mice; Mice, Knockout; Oxazines; Piperidines; Quinidine; Rats; Rats, Wistar; Reverse Transcriptase Inhibitors; Triazines | 2006 |
Some pharmacological actions of piperidine, pyrrolidine, and of pressor concentrates from dog urine.
Topics: Animals; Dogs; Piperidines; Pyrroles; Pyrrolidines; Quinidine | 1949 |
Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
Topics: Algorithms; Animals; Antimalarials; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Dantrolene; Erlotinib Hydrochloride; Flavonoids; Kinetics; Male; Mice; Mice, Knockout; Mitoxantrone; Muscle Relaxants, Central; Neoplasm Proteins; Piperidines; Protein Kinase Inhibitors; Quinazolines; Quinidine; Testis; Tissue Distribution; Xenobiotics | 2010 |
Exploiting transport activity of p-glycoprotein at the blood-brain barrier for the development of peripheral cannabinoid type 1 receptor antagonists.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Blotting, Western; Cannabinoid Receptor Antagonists; Cell Line; Humans; Kinetics; Male; Neoplasm Proteins; Piperidines; Pyrazoles; Quinidine; Rats; Rats, Wistar; Rimonabant; Tandem Mass Spectrometry; Tetrahydroisoquinolines | 2012 |
Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes.
Topics: Cardiotoxicity; Cell Differentiation; Drug Discovery; Haloperidol; Human Embryonic Stem Cells; Humans; Induced Pluripotent Stem Cells; Isoproterenol; Myocytes, Cardiac; Piperidines; Pyridines; Quinidine | 2017 |
In silico assessment of the effects of quinidine, disopyramide and E-4031 on short QT syndrome variant 1 in the human ventricles.
Topics: Action Potentials; Arrhythmias, Cardiac; Cell Line; Disopyramide; Electrocardiography; ERG1 Potassium Channel; Heart Ventricles; Humans; Models, Biological; Piperidines; Polymorphism, Single Nucleotide; Pyridines; Quinidine | 2017 |
Modelling the effects of quinidine, disopyramide, and E-4031 on short QT syndrome variant 3 in the human ventricles.
Topics: Action Potentials; Arrhythmias, Cardiac; Disopyramide; Heart Conduction System; Heart Defects, Congenital; Heart Ventricles; Humans; Models, Biological; Piperidines; Pyridines; Quinidine | 2017 |
KCNT1-positive epilepsy of infancy with migrating focal seizures successfully treated with nonnarcotic antitussive drugs after treatment failure with quinidine: A case report.
Topics: Antitussive Agents; Dextromethorphan; Electroencephalography; Epilepsy; Humans; Infant; Magnetic Resonance Imaging; Male; Mutation; Nerve Tissue Proteins; Piperidines; Potassium Channels, Sodium-Activated; Quinidine; Seizures; Treatment Failure; Treatment Outcome | 2020 |
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil | 2020 |