quinidine has been researched along with morphine in 53 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (30.19) | 18.7374 |
| 1990's | 4 (7.55) | 18.2507 |
| 2000's | 22 (41.51) | 29.6817 |
| 2010's | 11 (20.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Dagenais, C; Ducharme, J; Pollack, GM; Zong, J | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 2 |
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Thakker, DR; Troutman, MD | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Jolivette, LJ; Ward, KW | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Gibson, TC | 1 |
| Angelo, HR; Arendt-Nielsen, L; Bjerring, P; Brøsen, K; Eriksen, B; Gram, LF; Sindrup, SH | 1 |
| Agon, P; Bogaert, MG; Goethals, P; Kaufman, JM; Van Haver, D | 1 |
| Ivanova, TN; Pavlova, LT | 1 |
| Almirante, L; Murmann, W; Saccani-Guelfi, M | 1 |
| Beattie, JM; Demetriou, JA; Lowe, ML; Weissman, N | 1 |
| Blackmore, DJ; Curry, AS; Hayes, TS; Rutter, ER | 1 |
| Brochmann-Hanssen, E; Fontan, CR | 1 |
| Stone, TW | 1 |
| Bochner, F; Eichelbaum, M; Horak, P; Mikus, G; Somogyi, AA; Spector, S | 1 |
| Asmussen, J; Broen Christensen, C; Brøsen, K; Hofmann, U; Ingwersen, SH; Mikus, G; Nielsen, F; Sindrup, SH | 1 |
| Caraco, Y; Sheller, J; Wood, AJ | 1 |
| FORTIN, P | 1 |
| GIULIANI, G | 1 |
| ROCHEMAURE, J | 1 |
| DEXTER, L; PIEMME, TE | 1 |
| MACKENZIE, GJ; PASCUAL, S | 1 |
| PESTEL, M | 1 |
| Erb, K; Geisslinger, G; Jarrar, M; Lötsch, J; Schmidt, H; Skarke, C | 1 |
| Hoffer, C; Kharasch, ED; Sheffels, P; Whittington, D | 1 |
| ESTANDIA, A; FORD, TJ; HARRIS, AS; TILLOTSON, RF | 1 |
| Cisternino, S; Debray, M; Rousselle, C; Scherrmann, JM | 1 |
| Bianchi, E; Cadet, P; Esch, T; Goumon, Y; Mantione, KJ; Shen, L; Sonetti, D; Stefano, GB; Zhu, W | 1 |
| Raffa, RB; Stone, DJ | 1 |
| Bisaga, A; Daniel, WA; Kos, T; Popik, P; Wójcikowski, J | 1 |
| Ito, Y; Kagawa, Y; Kimura, M; Okura, T; Ozawa, T; Yamada, S | 1 |
| Ito, Y; Kagawa, Y; Morita, Y; Okura, T; Yamada, S | 1 |
| Capasso, A; Gallo, C | 1 |
| Iwanaga, K; Kakemi, M; Minamida, M; Miyazaki, M; Nishimura, C | 1 |
| Al-Huniti, N; Bui, K; Butler, K; She, F; Sostek, M; Zhou, D | 1 |
2 review(s) available for quinidine and morphine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The heart in myasthenia gravis.
Topics: Arrhythmias, Cardiac; Cholinesterase Inhibitors; Drug Synergism; Electrocardiography; Heart; Humans; Lidocaine; Meperidine; Methadone; Morphine; Myasthenia Gravis; Myocarditis; Myocardium; Neuromuscular Junction; Phenytoin; Procaine; Quinidine; Vectorcardiography | 1975 |
6 trial(s) available for quinidine and morphine
| Article | Year |
|---|---|
The effect of quinidine on the analgesic effect of codeine.
Topics: Adult; Codeine; Double-Blind Method; Drug Interactions; Female; Humans; Male; Morphine; Pain Measurement; Quinidine | 1992 |
Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Blood-Brain Barrier; Central Nervous System; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Methylation; Middle Aged; Mixed Function Oxygenases; Morphine; Quinidine; Sparteine | 1996 |
Impact of ethnic origin and quinidine coadministration on codeine's disposition and pharmacodynamic effects.
Topics: Adult; Analgesics, Opioid; Asian People; Biotransformation; Codeine; Cross-Over Studies; Dealkylation; Debrisoquin; Double-Blind Method; Drug Interactions; Enzyme Inhibitors; Female; Humans; Male; Morphine; Psychomotor Performance; Pupil; Quinidine; Respiratory Mechanics; White People | 1999 |
Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine.
Topics: Adrenergic alpha-Antagonists; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Double-Blind Method; Electrocardiography; Female; Humans; Infusions, Intravenous; Male; Miosis; Morphine; Pain Measurement; Quinidine; Respiration | 2003 |
Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Analgesics, Opioid; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cross-Over Studies; Double-Blind Method; Drug Interactions; Female; Half-Life; Humans; Injections, Intravenous; Intestinal Absorption; Male; Metabolic Clearance Rate; Morphine; Quinidine | 2003 |
The effect of quinidine, a strong P-glycoprotein inhibitor, on the pharmacokinetics and central nervous system distribution of naloxegol.
Topics: Adult; Analgesics, Opioid; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Central Nervous System; Cross-Over Studies; Double-Blind Method; Female; Humans; Male; Morphinans; Morphine; Pain; Polyethylene Glycols; Quinidine; Receptors, Opioid, mu | 2016 |
45 other study(ies) available for quinidine and morphine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Knockout; Morphine; Narcotics; Perfusion; Quinidine; Sex Characteristics; Substrate Specificity; Verapamil | 2001 |
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding | 2002 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution | 2005 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Study with positron emission tomography of the osmotic opening of the dog blood-brain barrier for quinidine and morphine.
Topics: Animals; Blood-Brain Barrier; Brain; Dogs; Evans Blue; Mannitol; Morphine; Osmosis; Quinidine; Tomography, Emission-Computed | 1988 |
[Correction of arrhythmia in the complex treatment of cardiac insufficiency and heart defects].
Topics: Adolescent; Adult; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Flutter; Cardiac Complexes, Premature; Electric Countershock; Female; Heart Failure; Heart Valve Diseases; Humans; Middle Aged; Morphine; Phenylephrine; Procainamide; Quinidine; Sodium Chloride; Strophanthins; Tachycardia | 1970 |
Effects of hexobarbitone, ether, morphine, and urethane upon the acute toxicity of propranolol and D-(--)-INPEA.
Topics: Amino Alcohols; Animals; Atropine; Bradycardia; Central Nervous System; Drug Synergism; Ethers; Heart Arrest; Heart Rate; Hexobarbital; Lidocaine; Male; Mice; Morphine; Nitrobenzenes; Propranolol; Quinidine; Seizures; Sleep; Urethane | 1966 |
Screening method for detection of drugs of abuse in human urine.
Topics: Alkaloids; Amphetamine; Analgesics; Barbiturates; Chlorpheniramine; Chromatography; Chromatography, Thin Layer; Codeine; Dextropropoxyphene; Histamine H1 Antagonists; Hot Temperature; Humans; Indicators and Reagents; Isonipecotic Acids; Meperidine; Methadone; Methods; Morphinans; Morphine; Pentazocine; Phenacetin; Phenothiazines; Quinidine; Substance-Related Disorders; Ultraviolet Rays | 1971 |
Automated analysis for drugs in urine.
Topics: Adult; Alkaloids; Amobarbital; Autoanalysis; Barbiturates; Chemistry, Clinical; Chlordiazepoxide; Fluorometry; Humans; Indicators and Reagents; Male; Methods; Morphine; Nicotine; Pentobarbital; Quinidine; Smoking; Spectrophotometry; Ultraviolet Rays | 1971 |
Gas chromatography of alkaloids with polar stationary liquids.
Topics: Alkaloids; Atropine; Chromatography, Gas; Cinchona; Cocaine; Codeine; Morphine; Papaverine; Pilocarpine; Plants, Medicinal; Quinidine; Quinine; Scopolamine; Strychnine; Thebaine | 1965 |
The effects of 4-aminopyridine on the isolated vas deferens and its effects on the inhibitory properties of adenosine, morphine, noradrenaline and gamma-aminobutyric acid.
Topics: 4-Aminopyridine; Adenosine; Aminopyridines; Animals; Calcium; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Neuromuscular Depolarizing Agents; Norepinephrine; Potassium Chloride; Quinidine; Tetraethylammonium Compounds; Vas Deferens | 1981 |
Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.
Topics: Adult; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Middle Aged; Mixed Function Oxygenases; Morphine; Phenotype; Polymorphism, Genetic; Quinidine | 1994 |
[VENTRICULAR TACHYCARDIA. (DIAGNOSIS AND TREATMENT)].
Topics: Digitalis Glycosides; Electric Countershock; Electric Stimulation Therapy; Electrocardiography; Hydroxyzine; Morphine; Potassium; Procainamide; Quinidine; Tachycardia; Tachycardia, Ventricular | 1963 |
[TREATMENT OF MYASTHENIA].
Topics: Adrenocorticotropic Hormone; Cyclopropanes; Epinephrine; Galantamine; Humans; Hypnotics and Sedatives; Isoflurophate; Morphine; Myasthenia Gravis; Neostigmine; Neuromuscular Nondepolarizing Agents; Nitrogen; Organophosphate Poisoning; Parasympathomimetics; Phosphorus; Poisons; Quinidine; Quinine; Surgical Procedures, Operative; Thymus Gland | 1964 |
[TREATMENT OF PAROXYSMAL TACHYCARDIA].
Topics: Acetylcholine; Alkaloids; Digitalis Glycosides; Electric Countershock; Electric Stimulation Therapy; Humans; Hydroxyzine; Morphine; Phenylephrine; Procainamide; Quinidine; Rauwolfia; Tachycardia; Tachycardia, Paroxysmal | 1964 |
DISORDERS OF THE PULMONARY CIRCULATION.
Topics: Aminophylline; Anti-Bacterial Agents; Antibiotics, Antitubercular; Diagnosis; Diet, Sodium-Restricted; Digitalis Glycosides; Diuretics; Humans; Hyperemia; Hypertension; Hypertension, Pulmonary; Morphine; Oxygen; Procaine; Pulmonary Circulation; Pulmonary Edema; Pulmonary Embolism; Pulmonary Heart Disease; Quinidine; Therapeutics; Vascular Surgical Procedures | 1964 |
PAROXYSMAL VENTRICULAR TACHYCARDIA.
Topics: Coronary Disease; Diagnosis; Digitalis Glycosides; Electrocardiography; Heart Failure; Hydrocortisone; Morphine; Mortality; Myocardial Infarction; Phenobarbital; Procainamide; Quinidine; Rheumatic Heart Disease; Statistics as Topic; Tachycardia; Tachycardia, Paroxysmal; Tachycardia, Ventricular; Toxicology | 1964 |
[WHAT SHOULD BE KNOWN ABOUT AURICULAR PAROXYSMAL TACHYCARDIA AND ITS TREATMENT].
Topics: Acetylcholine; Barbiturates; Child; Diagnosis; Digitalis Glycosides; Drug Therapy; Electrocardiography; Heart Block; Humans; Morphine; Phenylephrine; Potassium; Procainamide; Quinidine; Rauwolfia; Tachycardia; Tachycardia, Paroxysmal; Therapeutics | 1965 |
Quinidine lactate and gluconate in the suppression of ectopic ventricular tachycardias associated with myocardial infarction; control of toxicity by morphine.
Topics: Gluconates; Humans; Lactic Acid; Morphine; Myocardial Infarction; Quinidine; Tachycardia; Tachycardia, Ventricular; Ventricular Premature Complexes | 1951 |
In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Colchicine; Cyclosporins; Dexamethasone; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Progesterone; Quinidine; Verapamil; Vinblastine | 2004 |
Tyrosine and tyramine increase endogenous ganglionic morphine and dopamine levels in vitro and in vivo: cyp2d6 and tyrosine hydroxylase modulation demonstrates a dopamine coupling.
Topics: alpha-Methyltyrosine; Animals; Base Sequence; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; DNA, Complementary; Dopamine; Enzyme Inhibitors; Ganglia, Invertebrate; Molecular Sequence Data; Morphine; Mytilus edulis; Quinidine; RNA, Messenger; Tyramine; Tyrosine; Tyrosine 3-Monooxygenase; Up-Regulation | 2005 |
Unexceptional seizure potential of tramadol or its enantiomers or metabolites in mice.
Topics: Analgesics, Opioid; Animals; Codeine; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Hot Temperature; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Narcotic Antagonists; Oxycodone; Pain; Quinidine; Reserpine; Seizures; Stereoisomerism; Tramadol | 2008 |
Brain levels of dextromethorphan and the intensity of opioid withdrawal in mice.
Topics: Animals; Brain; Dextromethorphan; Dextrorphan; Dose-Response Relationship, Drug; Drug Synergism; Male; Mastication; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Motor Activity; Naloxone; Narcotic Antagonists; Quinidine; Stereotyped Behavior; Substance Withdrawal Syndrome | 2008 |
Enhancement by grapefruit juice of morphine antinociception.
Topics: Algorithms; Analgesics, Opioid; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Citrus paradisi; Drug Synergism; Drug Tolerance; Intestinal Absorption; Male; Microdialysis; Morphine; Pain Measurement; Quinidine; Rats; Rats, Sprague-Dawley; Reaction Time | 2008 |
Effects of quinidine on antinociception and pharmacokinetics of morphine in rats.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Dose-Response Relationship, Drug; Drug Synergism; Injections, Intravenous; Intestinal Absorption; Male; Metabolic Clearance Rate; Morphine; Pain Measurement; Quinidine; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2009 |
Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adenosine Triphosphate; Analgesics, Opioid; Animals; Caffeine; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Morphine Dependence; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Phenethylamines; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Quinidine; Receptor, Adenosine A1; Receptors, Adenosine A2; Receptors, Purinergic P2; Substance Withdrawal Syndrome; Theobromine; Theophylline | 2009 |
Pharmacokinetic assessment of absorptive interaction of oral etoposide and morphine in rats.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Drug Interactions; Etoposide; Intestinal Absorption; Male; Morphine; Propantheline; Quinidine; Rats; Rats, Wistar | 2014 |