Page last updated: 2024-08-17

quinidine and mexiletine

quinidine has been researched along with mexiletine in 123 studies

Research

Studies (123)

Timeframe	Studies, this research(%)	All Research%
pre-1990	75 (60.98)	18.7374
1990's	25 (20.33)	18.2507
2000's	11 (8.94)	29.6817
2010's	10 (8.13)	24.3611
2020's	2 (1.63)	2.80

Authors

Authors	Studies
Bódi, I; Frank, L; Hankovszky, OH; Hideg, K	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Campillo, NE; Guerra, A; Páez, JA	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Bruno, C; Budriesi, R; Carbonara, R; Carocci, A; Catalano, A; Colabufo, NA; Conte Camerino, D; De Palma, A; Desaphy, JF; Di Mola, A; Franchini, C; Ghelardini, C; Lentini, G; Perrone, MG	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Julian, DG	1
Theisen, K	1
Koch-Weser, J	1
Anderson, JL; Harrison, DC; Meffin, PJ; Winkle, RA	1
Kidner, PH	1
Chin, M; Franz, M; Herre, JM; Katzung, B; Newman, D; Scheinman, MM	1
Furukawa, T; Hiraoka, M; Marumo, F; Nitta, J; Sawanobori, T; Sunami, A	1
Kanno, M; Nakaya, H; Oyama, Y; Shishido, Y	1
Baĭer, T; Brakhmann, I; Khilbel, T; Kiubler, V; Shmitt, K; Valdeker, B	1
Deiwick, M; Konertz, W; Scheld, HH; Weyand, M	1
Fomina, IG; Iankin, VV	1
Duff, HJ; Gillis, AM; Mitchell, LB; Sheldon, RS; Wyse, DG	1
Duff, HJ; Rahmberg, M; Sheldon, RS	1
Abdalla, A; Mazur, NA; Nazarenko, VA	1
Arnold, RJ; Beck, JR; Beshansky, JR; Frishman, WH; Kaniecki, DJ; Kowey, PR; Podrid, PJ	1
Kadish, A; Morady, F; Toivonen, L	1
Gottlieb, SS; Weinberg, M	1
Kadish, AH; Morady, F; Rosenheck, S; Schmaltz, S; Summitt, J	1
Abdulla, AM; Frank, MJ; Manwaring, RL; Prisant, LM; Russell, SL; Smith, MS; Watkins, LO	1
Ford, SE; Saunders, SL	1
Broly, F; Caron, J; Lhermitte, M; Libersa, C; Vandamme, N	1
Kuang, Y; Liu, TP	1
Giardina, EG; Wechsler, ME	1
Accettura, D; De Toma, L; Lagioia, R; Mangini, SG; Mastropasqua, F; Rizzon, P; Scrutinio, D	1
Podrid, PJ	2
Honerjäger, P; Loibl, E; Schönsteiner, G; Steidl, I; Ulm, K	1
Bajaj, AK; Cassidy, F; Kopelman, HA; Roden, DM; Wikswo, JP; Woosley, RL	1
Accettura, D; Caiati, C; De Toma, L; Lagioia, R; Mangini, SG; Mastropasqua, F; Rizzon, P; Scrutinio, D	1
Iansmith, DH; Roden, DM; Woosley, RL	1
Abdalla, A; Mazur, NA	2
Graboys, TB; Grossbard, CL; Lown, B; Patt, MV	1
Abdalla, A; Iavorskaia, NV; Mazur, NA; Sumarokov, AB	1
Sanchez-Chapula, J; Valenzuela, C	1
Costard-Jaeckle, A; Franz, MR; Liem, LB	1
Barbey, JT; Echt, DS; Kopelman, HA; Murray, KT; Roden, DM; Siddoway, LA; Woosley, RL	1
Cannon, NJ; Duff, HJ; Sheldon, RS	1
Assey, ME; Hanger, KH; Hudson, WM; Miller, SC	1
Duff, HJ	1
Costard-Jäckle, A; Franz, MR	1
Yamaguchi, I	1
Somberg, J	1
Roden, DM; Siddoway, LA; Woosley, RL	1
Roy, D	1
Anderson, JL	1
Belhassen, B; Laniado, S; Pines, A	1
Morganroth, J; Nestico, PF	2
Huang, SK; Marcus, FI	1
Lampert, S; Lown, B; Podrid, PJ; Slater, W	1
Cody, DV; Denniss, AR; Richards, DA; Ross, DL; Russell, PA; Uther, JB; Young, AA	2
Duff, HJ; Manyari, DE; Mitchell, LB; Sheldon, RS; Wyse, DG	1
Morganroth, J	1
Garan, H; McElroy, M; McGovern, B; Newell, JB; Ruskin, JN; Schoenfeld, MH; Whitford, EG	1
Celentano, A; de Divitiis, O; Fazio, S; Iacono, C; Petitto, M; Santomauro, M; Villari, B	1
Horowitz, LN; Kay, HR; Kutalek, SP; Rae, AP; Spielman, SR	1
Duff, HJ; Manyari, D; Mitchell, LB; Wyse, DG	1
Cook, TS; DiMarco, JP; Nygaard, TW; Sellers, TD	1
Bardy, GH; Fahrenbruch, CE; Graham, EL; Greene, HL; Poole, JE; Pulaski, WP; Werner, JA	1
Giles, TD; Thomas, MG	1
Hirosawa, K; Kasanuki, H; Onishi, S	1
Collignon, P; Legrand, V	1
Berman, ND; Burke, GH; Loukides, JE	1
Greenspan, AM; Horowitz, LN; Rae, AP; Sokoloff, NM; Spielman, SR; Webb, CR	2
Adinolfi, L; Bonaduce, D; Chiariello, M; Dote, I; Golia, B; Masullo, LA	1
Opie, LH	1
Schmitz, W	1
Burckhardt, D; Follath, F; Hoffmann, A	1
Hillis, WS; Whiting, B	1
Somberg, JC	1
Ceci, V; Di Marcotullio, G; Dini, P; Milazzotto, F; Polizzi, C; Santini, M	1
Doherty, JU; Josephson, ME; Kienzle, MG; Williams, PD; Zygmont, D	1
Jahrmärker, H; Theisen, K	1
Kurbanov, RD; Mazur, NA	1
Courtney, KR	1
Cerskus, I; Duff, HJ; Roden, D; Siddoway, L; Stone, W; Thompson, K; Wang, T; Woosley, RL	1
Fenster, PE; Hanson, CD	1
Adams, E; Flessas, A; Kocot, SL; Rasul, AM; Shah, A; Singh, JB	1
Rosen, MR; Wit, AL	1
Block, PJ; Winkle, RA	1
Bigger, JT	1
Burckhardt, D; Follath, F; Hoffmann, A; Schütz, E; White, R	1
Chiang, BN; Hong, CY	1
Flouvat, B	1
Duff, HJ; Oates, JA; Primm, RK; Roden, D; Woosley, RL	1
DiMarco, JP; Garan, H; Ruskin, JN	1
Ban, T; Oshita, S; Sada, H	1
Adgey, AA; Logan, KR; McIlwaine, WJ; Pantridge, JF	1
Bigger, JT; Giardina, EG; Leahey, EB; Reiffel, JA	1
Bova, S; Magnolfi, G; Padrini, R; Piovan, D; Yang, Q	1
Broly, F; Courseau, C; Lhermitte, M; Libersa, C; Vandamme, N	1
Biblo, LA; Carlson, MD; Waldo, AL	1
Bonavita, GJ; Cuello, C; Greene, TO; Huang, SK; Mittleman, RS; Pires, LA; Wagshal, AB	1
Abolfathi, Z; Bélanger, PM; Fiset, C; Gilbert, M; Moerike, K; Turgeon, J	1
Campbell, TJ; Wyse, KR; Ye, V	1
Fernández del Pozo, B; Fernández, C; Pérez-Vizcaíno, F; Tamargo, J; Zaragozá, F	1
Ishii, K; Kubota, Y; Moriuchi, H; Nakahara, T; Sakamato, K; Shigenobu, K; Tanaka, Y; Yunoki, M	1
Ackerman, MJ; Jahangir, A; Makielski, JC; Munger, TM; Porter, CB; Rok, BA; Tester, DJ; Valdivia, CR	1
Ai, T; Cheng, J; Li, Z; Merkle, EM; Razavi, M; Shuraih, M; Sohma, Y; Taylor, E; Towbin, JA; Vatta, M; Xi, Y	1
Chen, YW; Cheng, KI; Chu, CC; Chu, KS; Huang, KL; Tzeng, JI; Wang, JJ	1
Chen, YC; Chen, YW; Chu, CC; Leung, YM; Wang, JJ	1
Cros, C; Lainee, P; Moors, J; Skinner, M; Valentin, JP	1
Osadchii, OE	1
Jæger, KH; Tveito, A; Wall, S	1
Deschênes, I; Zheng, Y	1

Reviews

20 review(s) available for quinidine and mexiletine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Cardiac arrhythmias - a short review. Scottish medical journal, 1976, Volume: 21, Issue:3 Topics: Adrenergic beta-Agonists; Arrhythmias, Cardiac; Digitalis Glycosides; Electric Countershock; Electrocardiography; Humans; Lidocaine; Mexiletine; Pacemaker, Artificial; Phenytoin; Procainamide; Quinidine; Verapamil	1976
Prevention of sudden coronary death by chronic antiarrhythmic therapy. Advances in cardiology, 1978, Volume: 25 Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Disopyramide; Drug Evaluation; Humans; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Time Factors; Ventricular Fibrillation	1978
Mexiletine/quinidine combination therapy: electrophysiologic correlates of anti-arrhythmic efficacy. Clinical and investigative medicine. Medecine clinique et experimentale, 1991, Volume: 14, Issue:5 Topics: Animals; Arrhythmias, Cardiac; Drug Therapy, Combination; Electrophysiology; Heart; Humans; Mexiletine; Quinidine; Sodium Channels	1991
Comparative cost-effectiveness analysis of quinidine, procainamide and mexiletine. The American journal of cardiology, 1991, Dec-15, Volume: 68, Issue:17 Topics: Ambulatory Care; Arrhythmias, Cardiac; Cost-Benefit Analysis; Costs and Cost Analysis; Decision Making, Computer-Assisted; Decision Support Techniques; Decision Trees; Hospitalization; Humans; Meta-Analysis as Topic; Mexiletine; Myocardial Infarction; Probability; Procainamide; Quinidine; Sensitivity and Specificity; Time Factors	1991
The role of antiarrhythmic drugs in prevention of sudden cardiac death. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide	1985
[The interaction of antiarrhythmic drugs with other drugs]. Kokyu to junkan. Respiration & circulation, 1985, Volume: 33, Issue:8 Topics: Adrenergic beta-Agonists; Amiodarone; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Digoxin; Drug Interactions; Humans; Lidocaine; Mexiletine; Phenytoin; Procainamide; Quinidine	1985
Antiarrhythmic drug therapy. Recent advances and current status. Cardiology, 1985, Volume: 72, Issue:5-6 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil	1985
Clinical pharmacology of old and new antiarrhythmic drugs. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Benzeneacetamides; Biological Availability; Bretylium Compounds; Disopyramide; Encainide; Flecainide; Humans; Imipramine; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Tocainide	1985
Antiarrhythmic drugs. Canadian Anaesthetists' Society journal, 1986, Volume: 33, Issue:3 Pt 2 Topics: Action Potentials; Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium Channel Blockers; Cell Membrane; Disopyramide; Electrophysiology; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1986
Rationale of combination antiarrhythmic drug therapy. Cardiovascular clinics, 1985, Volume: 16, Issue:1 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Digitalis Glycosides; Drug Therapy, Combination; Humans; Mexiletine; Myocardial Infarction; Quinidine; Tachycardia; Verapamil	1985
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment. Cardiology clinics, 1986, Volume: 4, Issue:2 Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil	1986
Antiarrhythmic drug therapy of ventricular arrhythmias. Current problems in cardiology, 1986, Volume: 11, Issue:4 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil	1986
Antiarrhythmic agents for chronic ventricular arrhythmias. Comprehensive therapy, 1987, Volume: 13, Issue:4 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Encainide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine; Tocainide	1987
[Electrophysiological classification of newer antiarrhythmic drugs (author's transl)]. Klinische Wochenschrift, 1980, Sep-15, Volume: 58, Issue:18 Topics: Action Potentials; Adrenergic beta-Antagonists; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Piperidines; Propafenone; Propiophenones; Quinidine; Sodium; Tocainide	1980
Antiarrhythmic drug therapy for sustained ventricular tachycardia. Heart & lung : the journal of critical care, 1984, Volume: 13, Issue:6 Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bethanidine; Calcium Channel Blockers; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Encainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Phenytoin; Piperidines; Procainamide; Quinidine; Tachycardia; Tocainide	1984
[Medical treatment of extrasystole and tachycardia (author's transl)]. MMW, Munchener medizinische Wochenschrift, 1980, Jan-18, Volume: 122, Issue:3 Topics: Action Potentials; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Digoxin; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil	1980
Pharmacology, electrophysiology, and pharmacokinetics of mexiletine. American heart journal, 1984, Volume: 107, Issue:5 Pt 2 Topics: Absorption; Animals; Arrhythmias, Cardiac; Drug Combinations; Drug Evaluation; Electrophysiology; Humans; Ion Channels; Kinetics; Mexiletine; Propylamines; Purkinje Fibers; Quinidine	1984
Electropharmacology of antiarrhythmic drugs. American heart journal, 1983, Volume: 106, Issue:4 Pt 2 Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil	1983
Hemodynamic effects of antiarrhythmic drugs. The American journal of cardiology, 1983, Sep-22, Volume: 52, Issue:6 Topics: Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Bretylium Compounds; Calcium Channel Blockers; Disopyramide; Dose-Response Relationship, Drug; Encainide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Myocardial Contraction; Phenytoin; Piperidines; Procainamide; Quinidine; Tocainide	1983

Trials

22 trial(s) available for quinidine and mexiletine

Article	Year
Prevention of sudden coronary death by chronic antiarrhythmic therapy. Advances in cardiology, 1978, Volume: 25 Topics: Amiodarone; Anti-Arrhythmia Agents; Aprindine; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Disopyramide; Drug Evaluation; Humans; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Time Factors; Ventricular Fibrillation	1978
[Prospective course of therapy arresting attacks of atrial fibrillation in patients with preexcitation syndromes]. Klinicheskaia meditsina, 1992, Volume: 70, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Pre-Excitation Syndromes; Procainamide; Propranolol; Quinidine; Time Factors; Verapamil	1992
[Comparative effectiveness of class I anti-arrhythmia drugs and the algorithms of their selection in patients with ventricular arrhythmia]. Kardiologiia, 1991, Volume: 31, Issue:6 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Disopyramide; Heart Conduction System; Heart Ventricles; Humans; Mexiletine; Middle Aged; Quinidine	1991
Comparative hemodynamic effects of mexiletine and quinidine in patients with severe left ventricular dysfunction. American heart journal, 1991, Volume: 122, Issue:5 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Drug Evaluation; Female; Heart Failure; Heart Ventricles; Hemodynamics; Humans; Male; Mexiletine; Middle Aged; Quinidine; Time Factors	1991
Mexiletine versus quinidine as first-line antiarrhythmia therapy: results from consecutive trials. Journal of clinical pharmacology, 1991, Volume: 31, Issue:3 Topics: Aged; Clinical Trials as Topic; Drug Evaluation; Female; Follow-Up Studies; Humans; Male; Mexiletine; Middle Aged; Quinidine; Retrospective Studies; Tachycardia	1991
Low dose quinidine-mexiletine combination therapy versus quinidine monotherapy for treatment of ventricular arrhythmias. Journal of the American College of Cardiology, 1990, Volume: 15, Issue:5 Topics: Arrhythmias, Cardiac; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Humans; Male; Mexiletine; Quinidine; Randomized Controlled Trials as Topic; Single-Blind Method; Stroke Volume	1990
[Comparison of mexiletine and dihydroquinidine in the treatment of ventricular asystolic arrhythmia]. Cardiologia (Rome, Italy), 1985, Volume: 30, Issue:2 Topics: Adult; Aged; Arrhythmias, Cardiac; Asthenia; Cardiac Complexes, Premature; Clinical Trials as Topic; Coronary Disease; Double-Blind Method; Female; Humans; Male; Mexiletine; Middle Aged; Propylamines; Quinidine; Random Allocation	1985
The role of antiarrhythmic drugs in prevention of sudden cardiac death. Cardiovascular clinics, 1985, Volume: 15, Issue:3 Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Death, Sudden; Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Random Allocation; Tocainide	1985
[Experience in using anti-arrhythmia preparations of groups I and III in patients with arrhythmia resistant to therapy]. Kardiologiia, 1988, Volume: 28, Issue:3 Topics: Aconitine; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Drug Resistance; Drug Therapy, Combination; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Quinidine	1988
[Comparative study of the effectiveness of allapinin in patients with frequent and stable extrasystole]. Kardiologiia, 1988, Volume: 28, Issue:11 Topics: Aconitine; Aconitum; Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Placebos; Propranolol; Quinidine	1988
Mexiletine and tocainide: a comparison of antiarrhythmic efficacy, adverse effects, and predictive value of lidocaine testing. Clinical pharmacology and therapeutics, 1989, Volume: 45, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Arrhythmias, Cardiac; Drug Evaluation; Drug Resistance; Drug Therapy, Combination; Electric Stimulation; Female; Heart Ventricles; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Prospective Studies; Quinidine; Random Allocation; Tocainide	1989
Comparative study of mexiletine and quinidine in the treatment of ventricular ectopia. Southern medical journal, 1985, Volume: 78, Issue:5 Topics: Administration, Oral; Adult; Aged; Cardiac Complexes, Premature; Clinical Trials as Topic; Double-Blind Method; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Propylamines; Quinidine; Random Allocation	1985
Randomized controlled trial of prophylactic antiarrhythmic therapy in patients with inducible ventricular tachyarrhythmias after recent myocardial infarction. European heart journal, 1988, Volume: 9, Issue:7 Topics: Actuarial Analysis; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Disopyramide; Electric Stimulation; Electrocardiography; Heart Ventricles; Humans; Mexiletine; Myocardial Infarction; Prognosis; Quinidine; Random Allocation	1988
Effect of oral combination therapy with mexiletine and quinidine on left and right ventricular function. American heart journal, 1988, Volume: 115, Issue:5 Topics: Cardiac Pacing, Artificial; Clinical Trials as Topic; Drug Therapy, Combination; Electrophysiology; Exercise Test; Female; Humans; Male; Mexiletine; Middle Aged; Myocardial Contraction; Quinidine; Stroke Volume; Tachycardia	1988
Comparative efficacy and safety of oral mexiletine and quinidine in benign or potentially lethal ventricular arrhythmias. The American journal of cardiology, 1987, Dec-01, Volume: 60, Issue:16 Topics: Administration, Oral; Arrhythmias, Cardiac; Central Nervous System Diseases; Clinical Trials as Topic; Electrocardiography; Female; Gastrointestinal Diseases; Humans; Male; Mexiletine; Quinidine	1987
[Antiarrhythmic efficacy and tolerance of slow-release mexiletine in comparison with hydroquinidine retard]. Minerva cardioangiologica, 1987, Volume: 35, Issue:11 Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Delayed-Action Preparations; Drug Evaluation; Exercise Test; Female; Humans; Male; Mexiletine; Middle Aged; Quinidine; Random Allocation	1987
Electrophysiologic assessment of antiarrhythmic drug efficacy for ventricular tachyarrhythmias associated with dilated cardiomyopathy. The American journal of cardiology, 1987, Feb-01, Volume: 59, Issue:4 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Procainamide; Quinidine; Tachycardia; Time Factors; Ventricular Fibrillation	1987
[Comparative effectiveness of ethmozine, mexitil, quinidine and obsidan in the treatment of ventricular rhythm disorders]. Kardiologiia, 1981, Volume: 21, Issue:10 Topics: Adolescent; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Humans; Mexiletine; Middle Aged; Moricizine; Morpholines; Phenothiazines; Placebos; Propranolol; Quinidine	1981
Mexiletine and quinidine in ventricular ectopy. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:2 Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Propylamines; Quinidine	1983
Efficacy of mexiletine in chronic ventricular arrhythmias compared with quinidine: a single-blind, randomized trial. The American journal of cardiology, 1984, Jan-01, Volume: 53, Issue:1 Topics: Adult; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Propylamines; Quinidine	1984
Insights into the Electrophysiology Study Versus Electrocardiographic Monitoring Trial: its programmed stimulation protocol may introduce bias when assessing long-term antiarrhythmic drug therapy. Journal of the American College of Cardiology, 1995, Volume: 25, Issue:7 Topics: Anti-Arrhythmia Agents; Bias; Cardiac Pacing, Artificial; Drug Combinations; Electrocardiography, Ambulatory; Electrophysiology; Follow-Up Studies; Humans; Mexiletine; Procainamide; Quinidine; Research Design; Retrospective Studies; Sotalol; Tachycardia, Ventricular	1995
Usefulness of oral quinidine-mexiletine combination therapy for sustained ventricular tachyarrhythmias as assessed by programmed electrical stimulation when quinidine monotherapy has failed. American heart journal, 1994, Volume: 127, Issue:4 Pt 1 Topics: Adult; Aged; Cardiac Pacing, Artificial; Drug Therapy, Combination; Electric Stimulation; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Prospective Studies; Quinidine; Tachycardia, Ventricular; Treatment Failure	1994

Other Studies

83 other study(ies) available for quinidine and mexiletine

Article	Year
New antiarrhythmic agents. 2,2,5,5-Tetramethyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylpyrrolidine-3-carboxamindes. Journal of medicinal chemistry, 1986, Volume: 29, Issue:7 Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation, Preclinical; Indicators and Reagents; Magnetic Resonance Spectroscopy; Nicotine; Ouabain; Rats; Spectrophotometry, Infrared; Structure-Activity Relationship	1986
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels. Journal of medicinal chemistry, 2012, Feb-09, Volume: 55, Issue:3 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Ataxia; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Caco-2 Cells; Guinea Pigs; Heart; Heart Rate; HEK293 Cells; Humans; Ion Channel Gating; Mexiletine; Mice; NAV1.5 Voltage-Gated Sodium Channel; Permeability; Sodium Channels; Stereoisomerism; Vasodilator Agents	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
[Drug therapy of tachyarrhythmias (author's transl)]. Klinische Wochenschrift, 1978, Feb-15, Volume: 56, Issue:4 Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil	1978
Antiarrhythmic drugs: clinical pharmacology and therapeutic uses. Drugs, 1978, Volume: 15, Issue:4 Topics: Acebutolol; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digitalis Glycosides; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil	1978
Prevention of ventricular arrhythmias after myocardial infarction. Journal of the Royal College of Physicians of London, 1977, Volume: 11, Issue:4 Topics: Disopyramide; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Procainamide; Propranolol; Quinidine; Ventricular Fibrillation	1977
Effects of sympathetic stimulation on use dependence of lidocaine, mexiletine, and quinidine in an intact canine model. Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:2 Topics: Action Potentials; Animals; Chromatography, High Pressure Liquid; Dogs; Electric Stimulation; Female; Heart Conduction System; In Vitro Techniques; Lidocaine; Male; Mexiletine; Quinidine; Sodium Channels; Stellate Ganglion; Sympathetic Nervous System	1992
Combined class I antiarrhythmic agents have differential effects on tonic and use dependent block of maximum rate of depolarisation of action potentials in guinea pig cardiac muscle. Cardiovascular research, 1992, Volume: 26, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Aprindine; Disopyramide; Drug Combinations; Guinea Pigs; Lidocaine; Mexiletine; Myocardium; Quinidine; Sodium Channels	1992
Voltage-dependent modification of Vmax recovery from use-dependent block by pirmenol in guinea pig papillary muscles: comparison with other class I drugs. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Flecainide; Guinea Pigs; Heart; In Vitro Techniques; Membrane Potentials; Mexiletine; Microelectrodes; Neuromuscular Depolarizing Agents; Papillary Muscles; Piperidines; Propylamines; Pyridines; Quinidine; Sodium Channels	1992
[Anti-arrhythmia agents in heart failure]. Kardiologiia, 1992, Volume: 32, Issue:4 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Flecainide; Humans; Mexiletine; Middle Aged; Propafenone; Quinidine	1992
Is pretransplant antiarrhythmic drug therapy a risk factor? Transplantation proceedings, 1992, Volume: 24, Issue:6 Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Cause of Death; Child; Female; Follow-Up Studies; Heart Transplantation; Humans; Male; Mexiletine; Middle Aged; Postoperative Complications; Premedication; Propafenone; Quinidine; Sotalol; Survival Rate; Transplantation, Heterotopic	1992
Role of quinidine in the mexiletine-quinidine interaction: electrophysiologic correlates of enhanced antiarrhythmic efficacy. Journal of cardiovascular pharmacology, 1990, Volume: 16, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Diazepam; Dogs; Drug Combinations; Drug Interactions; Heart Conduction System; Mexiletine; Quinidine; Quinine; Refractory Period, Electrophysiological	1990
A prospective comparison of class IA, B, and C antiarrhythmic agents in combination with amiodarone in patients with inducible, sustained ventricular tachycardia. Circulation, 1991, Volume: 84, Issue:1 Topics: Amiodarone; Anilides; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electrocardiography; Encainide; Heart Conduction System; Humans; Mexiletine; Prospective Studies; Quinidine; Tachycardia	1991
The effect of quinidine and mexiletine on the adaptation of ventricular refractoriness to an increase in rate. American heart journal, 1991, Volume: 121, Issue:2 Pt 1 Topics: Adaptation, Physiological; Adult; Aged; Drug Evaluation; Electrophysiology; Female; Heart; Heart Rate; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Quinidine; Syncope; Tachycardia; Tachycardia, Paroxysmal	1991
Primary coronary artery dissection possibly related to drug hypersensitivity in a male. The Canadian journal of cardiology, 1991, Volume: 7, Issue:3 Topics: Aortic Dissection; Coronary Aneurysm; Drug Hypersensitivity; Humans; Male; Mexiletine; Middle Aged; Quinidine	1991
Single-dose quinidine treatment inhibits mexiletine oxidation in extensive metabolizers of debrisoquine. Life sciences, 1991, Volume: 48, Issue:26 Topics: Debrisoquin; Drug Antagonism; Humans; Metabolic Clearance Rate; Mexiletine; Oxidation-Reduction; Quinidine	1991
Rate-dependent depression of maximal rate of depolarization in guinea pig papillary muscle action potentials by changrolin. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1990, Volume: 11, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Female; Guinea Pigs; In Vitro Techniques; Male; Mexiletine; Papillary Muscles; Piperidines; Quinazolines; Quinidine	1990
Negative inotropic effects of tetrodotoxin and seven class 1 antiarrhythmic drugs in relation to sodium channel blockade. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 332, Issue:2 Topics: Action Potentials; Androstanols; Animals; Anti-Arrhythmia Agents; Aprindine; Calcium; Depression, Chemical; Disopyramide; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ion Channels; Isoquinolines; Kinetics; Male; Membrane Potentials; Mexiletine; Microelectrodes; Myocardial Contraction; Myocardium; Potassium; Quinidine; Sodium; Sodium-Potassium-Exchanging ATPase; Sparteine; Tetrodotoxin	1986
Frequency- and orientation-dependent effects of mexiletine and quinidine on conduction in the intact dog heart. Circulation, 1987, Volume: 75, Issue:5 Topics: Animals; Cardiac Pacing, Artificial; Dogs; Drug Combinations; Electrocardiography; Heart Conduction System; Ion Channels; Mexiletine; Myocardial Contraction; Quinidine; Sodium	1987
[Evaluation of delayed-action preparations of mexiletine and dihydroquinidine in the treatment of ventricular extrasystolic arrhythmia]. Cardiologia (Rome, Italy), 1987, Volume: 32, Issue:9 Topics: Aged; Cardiac Complexes, Premature; Delayed-Action Preparations; Double-Blind Method; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Quinidine; Random Allocation	1987
Frequency-dependent interactions of mexiletine and quinidine on depolarization and repolarization in canine Purkinje fibers. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:3 Topics: Action Potentials; Animals; Dogs; Drug Synergism; Electric Stimulation; Heart Conduction System; In Vitro Techniques; Ion Channels; Mexiletine; Purkinje Fibers; Quinidine; Sodium	1987
[The effectiveness of a combination of mexitil with etmozin, allapinin or quinidine in ventricular extrasystole]. Klinicheskaia meditsina, 1988, Volume: 66, Issue:5 Topics: Aconitine; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Drug Evaluation; Drug Therapy, Combination; Drug Tolerance; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Phenothiazines; Quinidine	1988
Combination antiarrhythmic therapy for management of malignant ventricular arrhythmia. The American journal of cardiology, 1988, Nov-03, Volume: 62, Issue:14 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Quinidine; Tachycardia; Tocainide	1988
Electrophysiologic interactions between mexiletine-quinidine and mexiletine-ropitoin in guinea pig papillary muscle. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:5 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Drug Interactions; Electric Stimulation; Electrophysiology; Female; Guinea Pigs; Heart; In Vitro Techniques; Kinetics; Male; Membrane Potentials; Mexiletine; Papillary Muscles; Phenytoin; Quinidine; Temperature	1989
Frequency-dependent effect of quinidine, mexiletine, and their combination on postrepolarization refractoriness in vivo. Journal of cardiovascular pharmacology, 1989, Volume: 14, Issue:6 Topics: Action Potentials; Animals; Blood Pressure; Dogs; Drug Therapy, Combination; Female; Heart Rate; In Vitro Techniques; Male; Mexiletine; Neural Conduction; Quinidine; Refractory Period, Electrophysiological	1989
Mexiletine-quinidine in isolated hearts: an interaction involving the sodium channel. Cardiovascular research, 1989, Volume: 23, Issue:7 Topics: Action Potentials; Animals; Coronary Disease; Drug Synergism; Drug Therapy, Combination; Heart; Heart Ventricles; Mexiletine; Myocardial Infarction; Myocardial Reperfusion; Quinidine; Rabbits; Sodium Channels; Tetrodotoxin; Ventricular Fibrillation	1989
Mexiletine-quinidine combination: enhanced antiarrhythmic and electrophysiologic activity in the dog. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Dogs; Drug Synergism; Drug Therapy, Combination; Heart Conduction System; Mexiletine; Quinidine	1989
Frequency-dependent antiarrhythmic drug effects on postrepolarization refractoriness and ventricular conduction time in canine ventricular myocardium in vivo. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 251, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; Female; Heart; Heart Conduction System; Heart Ventricles; Lidocaine; Male; Mexiletine; Quinidine	1989
Failure of corticosteroid therapy to prevent induction of ventricular tachycardia in sarcoidosis. Chest, 1989, Volume: 95, Issue:4 Topics: Adult; Amiodarone; Cardiac Pacing, Artificial; Cardiomyopathies; Disopyramide; Drug Therapy, Combination; Electrophysiology; Fluocortolone; Humans; Male; Mexiletine; Quinidine; Sarcoidosis; Tachycardia	1989
Clinical predictors of arrhythmia worsening by antiarrhythmic drugs. The American journal of cardiology, 1988, Feb-01, Volume: 61, Issue:4 Topics: Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Electrocardiography; Encainide; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Quinidine; Retrospective Studies	1988
Long-term efficacy of mexiletine alone and in combination with class Ia antiarrhythmic drugs for refractory ventricular arrhythmias. American heart journal, 1988, Volume: 115, Issue:2 Topics: Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Mexiletine; Middle Aged; Procainamide; Quinidine; Tachycardia; Time Factors	1988
Mexiletine-quinidine combination: electrophysiologic correlates of a favorable antiarrhythmic interaction in humans. Journal of the American College of Cardiology, 1987, Volume: 10, Issue:5 Topics: Adult; Aged; Drug Synergism; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Quinidine; Tachycardia	1987
Adverse reactions to antiarrhythmic drugs during therapy for ventricular arrhythmias. JAMA, 1986, Jul-04, Volume: 256, Issue:1 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Procainamide; Prospective Studies; Quinidine; Tachycardia; Ventricular Fibrillation	1986
Intolerance and ineffectiveness of mexiletine in patients with serious ventricular arrhythmias. American heart journal, 1986, Volume: 112, Issue:2 Topics: Cardiac Pacing, Artificial; Disopyramide; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Female; Humans; Male; Mexiletine; Middle Aged; Monitoring, Physiologic; Nausea; Procainamide; Propylamines; Quinidine; Recurrence; Tachycardia; Tremor; Ventricular Fibrillation	1986
Effect of antiarrhythmic therapy on delayed potentials detected by the signal-averaged electrocardiogram in patients with ventricular tachycardia after acute myocardial infarction. The American journal of cardiology, 1986, Aug-01, Volume: 58, Issue:3 Topics: Action Potentials; Adult; Aged; Anti-Arrhythmia Agents; Electrocardiography; Heart Ventricles; Humans; Metoprolol; Mexiletine; Middle Aged; Myocardial Infarction; Quinidine; Tachycardia	1986
Mexiletine: long-term follow-up of a patient with prolonged QT interval and quinidine-induced torsades de pointes. Southern medical journal, 1985, Volume: 78, Issue:2 Topics: Electrocardiography; Follow-Up Studies; Humans; Long-Term Care; Male; Mexiletine; Middle Aged; Propylamines; Quinidine; Tachycardia	1985
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias. Japanese circulation journal, 1985, Volume: 49, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil	1985
Aggravation of ventricular arrhythmia. A drug-induced complication. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Drug Evaluation; Electrocardiography; Encainide; Flecainide; Humans; Mexiletine; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine	1985
Haemodynamic effects of class I antiarrhythmic agents. Drugs, 1985, Volume: 29 Suppl 4 Topics: Anti-Arrhythmia Agents; Disopyramide; Flecainide; Hemodynamics; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide	1985
Comparative electropharmacology of mexiletine, lidocaine and quinidine in a canine Purkinje fiber model. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:1 Topics: Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Heart; In Vitro Techniques; Lidocaine; Membrane Potentials; Mexiletine; Propylamines; Purkinje Fibers; Quinidine; Sodium; Time Factors	1986
Limitations of failure of procainamide during electrophysiologic testing to predict response to other medical therapy. Journal of the American College of Cardiology, 1985, Volume: 6, Issue:2 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Pacing, Artificial; Electric Stimulation; Electrophysiology; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Procainamide; Quinidine; Time Factors	1985
Efficacy of combination therapy with mexiletine and a type IA agent for inducible ventricular tachyarrhythmias secondary to coronary artery disease. The American journal of cardiology, 1985, Aug-01, Volume: 56, Issue:4 Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Coronary Disease; Drug Therapy, Combination; Electrophysiology; Female; Humans; Male; Mexiletine; Middle Aged; Procainamide; Quinidine; Tachycardia; Ventricular Fibrillation	1985
[Ventricular tachycardia]. Minerva medica, 1985, Nov-17, Volume: 76, Issue:44 Topics: Amiodarone; Aprindine; Digitalis Glycosides; Electrocardiography; Heart Aneurysm; Heart Ventricles; Humans; Mexiletine; Pacemaker, Artificial; Propranolol; Quinidine; Risk; Tachycardia; Tachycardia, Paroxysmal	1985
Drugs and the heart. IV. Antiarrhythmic agents. Lancet (London, England), 1980, Apr-19, Volume: 1, Issue:8173 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Heart Conduction System; Hemodynamics; Humans; Lidocaine; Mexiletine; Procainamide; Quinidine; Verapamil	1980
Safe treatment of resistant ventricular arrhythmias with a combination of amiodarone and quinidine or mexiletine. Lancet (London, England), 1983, Mar-26, Volume: 1, Issue:8326 Pt 1 Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Drug Therapy, Combination; Female; Heart Ventricles; Humans; Male; Mexiletine; Middle Aged; Quinidine	1983
Antiarrhythmic drugs. British medical journal (Clinical research ed.), 1983, Apr-23, Volume: 286, Issue:6374 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil	1983
New directions in antiarrhythmic drug therapy. The American journal of cardiology, 1984, Aug-13, Volume: 54, Issue:4 Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil	1984
[Combinations of some anti-arrhythmia drugs]. Giornale italiano di cardiologia, 1984, Volume: 14, Issue:5 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Digoxin; Drug Therapy, Combination; Humans; Mexiletine; Propafenone; Propiophenones; Quinidine	1984
Depressant effects of drugs used in myotonia therapy. Proceedings of the Western Pharmacology Society, 1982, Volume: 25 Topics: Animals; In Vitro Techniques; Ion Channels; Lidocaine; Mexiletine; Muscle Contraction; Myotonia; Phenytoin; Procainamide; Quinidine; Rana catesbeiana; Tocainide	1982
The interaction of mexiletine with other cardiovascular drugs. American heart journal, 1984, Volume: 107, Issue:5 Pt 2 Topics: Absorption; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Interactions; Drug Therapy, Combination; Humans; Kinetics; Mexiletine; Propylamines; Quinidine	1984
Suppression of high-grade ventricular ectopic activity by antiarrhythmic drug treatment as a marker for survival in patients with chronic coronary artery disease. American heart journal, 1984, Volume: 107, Issue:6 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Female; Humans; Male; Mexiletine; Middle Aged; Phenytoin; Prognosis; Quinidine; Retrospective Studies	1984
Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship. British journal of clinical pharmacology, 1984, Volume: 17, Issue:6 Topics: Anesthetics, Local; Anti-Arrhythmia Agents; Diltiazem; Humans; Labetalol; Male; Mexiletine; Procainamide; Quinidine; Sperm Immobilizing Agents	1984
[Determination of plasma concentrations of anti-arrhythmia agents]. Archives des maladies du coeur et des vaisseaux, 1981, Volume: 74 Spec No Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biological Availability; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Mexiletine; Procainamide; Propranolol; Quinidine	1981
Mexiletine in the treatment of resistant ventricular arrhythmias: enhancement of efficacy and reduction of dose-related side effects by combination with quinidine. Circulation, 1983, Volume: 67, Issue:5 Topics: Arrhythmias, Cardiac; Coronary Disease; Diarrhea; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Electrophysiology; Heart Ventricles; Humans; Mexiletine; Patient Compliance; Propylamines; Quinidine; Tachycardia; Ventricular Fibrillation	1983
Quinidine for ventricular arrhythmias: value of electrophysiologic testing. The American journal of cardiology, 1983, Jan-01, Volume: 51, Issue:1 Topics: Aged; Drug Therapy, Combination; Electric Stimulation; Electrocardiography; Female; Humans; Male; Mexiletine; Middle Aged; Propranolol; Quinidine; Tachycardia; Ventricular Fibrillation	1983
Effects of mexiletine on transmembrane action potentials as affected by external potassium concentration and by rate of stimulation in guinea-pig papillary muscles. Clinical and experimental pharmacology & physiology, 1980, Volume: 7, Issue:6 Topics: Action Potentials; Animals; Electric Stimulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Mexiletine; Papillary Muscles; Potassium; Propylamines; Quinidine	1980
Recurrence of ventricular fibrillation in acute ischemic heart disease. Circulation, 1981, Volume: 64, Issue:6 Topics: Acute Disease; Anti-Arrhythmia Agents; Coronary Disease; Female; Heart Arrest; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Quinidine; Recurrence; Resuscitation; Ventricular Fibrillation	1981
The effect of quinidine and other oral antiarrhythmic drugs on serum digoxin. A prospective study. Annals of internal medicine, 1980, Volume: 92, Issue:5 Topics: Aged; Anorexia; Anti-Arrhythmia Agents; Digoxin; Disopyramide; Drug Interactions; Female; Humans; Male; Mexiletine; Middle Aged; Nausea; Procainamide; Prospective Studies; Quinidine; Vomiting	1980
Electrocardiographic interactions between pinacidil, a potassium channel opener and class I antiarrhythmic agents in guinea-pig isolated perfused heart. British journal of pharmacology, 1995, Volume: 114, Issue:8 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrocardiography; Female; Guanidines; Guinea Pigs; Heart; Male; Mexiletine; Pinacidil; Potassium Channels; Quinidine; Vasodilator Agents	1995
Stereoselective hydroxylation of mexiletine in human liver microsomes: implication of P450IID6--a preliminary report. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:1 Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; Hydroxylation; In Vitro Techniques; Mexiletine; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Polymorphism, Genetic; Quinidine; Stereoisomerism	1993
Role of polymorphic debrisoquin 4-hydroxylase activity in the stereoselective disposition of mexiletine in humans. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 266, Issue:3 Topics: Administration, Oral; Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Female; Humans; Male; Mexiletine; Mixed Function Oxygenases; Phenotype; Polymorphism, Genetic; Quinidine; Stereoisomerism	1993
Effects of hyperkalaemia on the depression of maximum rate of depolarization by class I antiarrhythmic agents in guinea-pig myocardium. British journal of pharmacology, 1993, Volume: 108, Issue:1 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Disopyramide; Female; Guinea Pigs; Heart; Heart Ventricles; In Vitro Techniques; Male; Mexiletine; Microelectrodes; Potassium; Quinidine	1993
Effects of several class I antiarrhythmic drugs on isolated rat aortic vascular smooth muscle. General pharmacology, 1997, Volume: 29, Issue:4 Topics: Animals; Anti-Arrhythmia Agents; Aorta; Desipramine; Disopyramide; Flecainide; Imipramine; In Vitro Techniques; Lidocaine; Male; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Quinidine; Rats; Rats, Sprague-Dawley	1997
Involvement of K(+) channel in procainamide-induced relaxation of bovine tracheal smooth muscle. European journal of pharmacology, 2000, Aug-18, Volume: 402, Issue:1-2 Topics: Albuterol; Animals; Anti-Arrhythmia Agents; Bronchoconstrictor Agents; Bronchodilator Agents; Cattle; In Vitro Techniques; Methacholine Chloride; Mexiletine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Potassium Channels; Procainamide; Propafenone; Quinidine; Trachea	2000
A trafficking defective, Brugada syndrome-causing SCN5A mutation rescued by drugs. Cardiovascular research, 2004, Apr-01, Volume: 62, Issue:1 Topics: Adolescent; Animals; Arrhythmias, Cardiac; Cell Line; Humans; Long QT Syndrome; Male; Mexiletine; Mutation, Missense; Myocardium; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Pedigree; Quinidine; Sodium Channel Blockers; Sodium Channels; Transfection	2004
A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents. Journal of cardiovascular electrophysiology, 2007, Volume: 18, Issue:4 Topics: Anti-Arrhythmia Agents; Cells, Cultured; Flecainide; Genetic Variation; Humans; Ion Channel Gating; Mexiletine; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Quinidine; Sodium Channels	2007
The cutaneous analgesic effect of class I antiarrhythmic drugs. Anesthesia and analgesia, 2007, Volume: 104, Issue:4 Topics: Analgesics; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Dose-Response Relationship, Drug; Flecainide; Injections, Subcutaneous; Lidocaine; Male; Mexiletine; Pain Measurement; Pain Threshold; Quinidine; Rats; Rats, Sprague-Dawley; Reflex; Skin; Sodium Channel Blockers; Time Factors	2007
Spinal blockades of class I antiarrythmic drugs with bupivacaine by isobolographic analysis in rats. Neuroscience letters, 2012, Oct-18, Volume: 528, Issue:1 Topics: Anesthesia, Spinal; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Bupivacaine; Dose-Response Relationship, Drug; Flecainide; Injections, Spinal; Male; Mexiletine; Quinidine; Rats; Rats, Sprague-Dawley	2012
Detecting drug-induced prolongation of the QRS complex: new insights for cardiac safety assessment. Toxicology and applied pharmacology, 2012, Dec-01, Volume: 265, Issue:2 Topics: Animals; CHO Cells; Cricetinae; Dogs; Electrocardiography; Flecainide; Heart Rate; Male; Mexiletine; Patch-Clamp Techniques; Quinidine; Telemetry; Voltage-Gated Sodium Channel Blockers	2012
Effects of Na+ channel blockers on extrasystolic stimulation-evoked changes in ventricular conduction and repolarization. Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:3 Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrophysiological Phenomena; Female; Flecainide; Guinea Pigs; Heart Ventricles; Lidocaine; Mexiletine; Quinidine; Sodium Channel Blockers; Tachycardia, Ventricular	2014
Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes. PLoS computational biology, 2021, Volume: 17, Issue:2 Topics: Action Potentials; Adult; Ajmaline; Algorithms; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cell Line; Computational Biology; Drug Evaluation, Preclinical; Electrocardiography; ERG1 Potassium Channel; Heart Conduction System; Heart Defects, Congenital; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells; Ivabradine; Mexiletine; Models, Cardiovascular; Mutation; Myocytes, Cardiac; Quinidine; Translational Research, Biomedical	2021
Protein 14-3-3 Influences the Response of the Cardiac Sodium Channel Na The Journal of pharmacology and experimental therapeutics, 2023, Volume: 384, Issue:3 Topics: 14-3-3 Proteins; Anti-Arrhythmia Agents; HEK293 Cells; Humans; Lidocaine; Mexiletine; Quinidine; Sodium Channels	2023